PaperBLAST
PaperBLAST Hits for tr|Q9I1J9|Q9I1J9_PSEAE Probable alcohol dehydrogenase (Zn-dependent) OS=Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) OX=208964 GN=PA2275 PE=3 SV=1 (353 a.a., MTLQIRGYAA...)
Show query sequence
>tr|Q9I1J9|Q9I1J9_PSEAE Probable alcohol dehydrogenase (Zn-dependent) OS=Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) OX=208964 GN=PA2275 PE=3 SV=1
MTLQIRGYAAQSASTPLTAHRFERRAPRADDLVIDILYCGVCHSDLHQARNEWHNSLYPL
VPGHEIIGRVASVGEAVSGFAVGELVGVGCMVDSCRHCAACSEGLEQYCAEYPTLTYNGR
DRHDGLPTFGGYSERIVVSARFVLRIPQGLDPKAAAPLLCAGITSYSPLRHWKVGPGSRV
AVVGLGGLGHMGLKFARALGAEVALFTRSPGKEEEARRLGADQVILSTDPQRMAAVAGRF
DLILDTVPHQHDLNPYLATLKRDGTLVLVGLLEPLEPAVHGAQLVMGRRSIAGSAIGGIA
ETQEMLDFCAAHGIACDIEMIEIQQINQAYERMLASDVKYRFVIDMASLQKSF
Running BLASTp...
Found 251 similar proteins in the literature:
PA2275 probable alcohol dehydrogenase (Zn-dependent) from Pseudomonas aeruginosa PAO1
100% identity, 100% coverage
- The Pseudomonas aeruginosa RpoH (σ32) Regulon and Its Role in Essential Cellular Functions, Starvation Survival, and Antibiotic Tolerance
Williamson, International journal of molecular sciences 2023 - “...1.9 10 4 PA2106 Metal-dependent hydrolase, contains AlaS domain; alanyl-tRNA synthetase 2.2 2.2 10 3 PA2275 Alcohol dehydrogenase 7.2 2.0 10 4 PA2481 Cytochrome c oxidase, cbb3-type, subunit p 2.1 1.2 10 2 PA2559 23 kda subunit of oxygen evolving system of photosystem II of plants...”
- Advanced transcriptomic analysis reveals the role of efflux pumps and media composition in antibiotic responses of Pseudomonas aeruginosa
Rajput, Nucleic acids research 2022 - “...and predicted TCSs. PA2274 may be a response regulator with an associated histidine kinase of PA2275 ( Supplementary Notes 2 ). Therefore, ICA analysis of the P. aeruginosa transcriptome was helpful in the identification of two regulators (PA4878 ( brlR ) and PA2274) which potentially regulate...”
- Cinnamaldehyde Induces Expression of Efflux Pumps and Multidrug Resistance in Pseudomonas aeruginosa
Tetard, Antimicrobial agents and chemotherapy 2019 (secret) - Toxic Electrophiles Induce Expression of the Multidrug Efflux Pump MexEF-OprN in Pseudomonas aeruginosa through a Novel Transcriptional Regulator, CmrA
Juarez, Antimicrobial agents and chemotherapy 2017 - “...genes (homologs of PA2048, PA1881, PA1880 and 223 PA2275 in PA01) are predicted to encode oxidoreductases (a quinol monooxygenase, an 224 oxidoreductase, an...”
- “...Finally, we found that three 297 CmrA-regulated proteins (PA2048, PA2275 and PA2276) share 40% of amino acid 298 similarity with E. coli enzymes implicated in...”
- A comprehensive multi-omics approach uncovers adaptations for growth and survival of Pseudomonas aeruginosa on n-alkanes
Grady, BMC genomics 2017 - “...encode more than a dozen known and putative ADH enzymes, but of particular interest is PA2275, which is induced by ATCC 33988+alkanes at both the transcriptional and translational levels when compared to PAO1+alkanes. More work needs to be done on the substrate specificity of PA2275, but...”
PA14_35150 putative Zn-dependent alcohol dehydrogenase from Pseudomonas aeruginosa UCBPP-PA14
99% identity, 100% coverage
Q2RU91 Zinc-containing alcohol dehydrogenase superfamily from Rhodospirillum rubrum (strain ATCC 11170 / ATH 1.1.1 / DSM 467 / LMG 4362 / NCIMB 8255 / S1)
Rru_A1503 Zinc-containing alcohol dehydrogenase superfamily from Rhodospirillum rubrum ATCC 11170
73% identity, 97% coverage
KF946_04255 NAD(P)-dependent alcohol dehydrogenase from Idiomarina loihiensis
63% identity, 98% coverage
D0C713 GroES-like protein from Acinetobacter baumannii (strain ATCC 19606 / DSM 30007 / JCM 6841 / CCUG 19606 / CIP 70.34 / NBRC 109757 / NCIMB 12457 / NCTC 12156 / 81)
62% identity, 99% coverage
PP2426, PP_2426 D-isomer specific 2-hydroxyacid dehydrogenase family protein from Pseudomonas putida KT2440
68% identity, 97% coverage
- Metabolic engineering of Pseudomonas putida for production of vanillylamine from lignin-derived substrates
Manfrão-Netto, Microbial biotechnology 2021 - “...aldBII (PP_2680) and aldBI (PP_0545)), a benzaldehyde dehydrogenase (PP_1948) and the coniferyl alcohol dehydrogenase calA (PP_2426) were previously deleted (GarcaHidalgo etal ., 2020 ; Fig. 1 ). Also, genes coding for feruloylCoA synthetase ( fcs ) and enoylCoA hydratase/aldolase ( ech ) are also overexpressed, resulting...”
- “...ATA with activity against VA (Fig. S5 ). From this, it is clear that GN442 PP_2426 still carries endogenous dehydrogenase activity towards vanillin. Apparently, the ATAbased conversion of vanillin to VA competes with remaining vanillin dehydrogenase background activity converting it to byproducts and further metabolization. When...”
- Engineering a Cytochrome P450 for Demethylation of Lignin-Derived Aromatic Aldehydes
Ellis, JACS Au 2021 - “...5 BD), likely due to activity of the recently described vanillin reductase, AreA (encoded by PP_2426). 42 In ACB086 and ACB087, consumption of p- vanillin coincided with an increase in its demethylated product, protocatechuic aldehyde (PCAldehyde). Demethylated product yields in ACB086 remained relatively modest (0.04 mM...”
- Vanillin Production in Pseudomonas: Whole-Genome Sequencing of Pseudomonas sp. Strain 9.1 and Reannotation of Pseudomonas putida CalA as a Vanillin Reductase
García-Hidalgo, Applied and environmental microbiology 2020 - “...Pseudomonas putida KT2440. Recombinant expression of the Pseudomonas sp. 9.1 FEZ21_09870 and P. putida KT2440 PP_2426 ( calA ) genes in Escherichia coli revealed that these open reading frames encode aldehyde reductases that convert vanillin to vanillyl alcohol, and that P. putida KT2440 PP_3839 encodes a...”
- “...alcohol to coniferyl aldehyde (i.e., the function previously assigned to calA ). The deletion of PP_2426 in P. putida GN442 engineered to accumulate vanillin resulted in a decrease in by-product (vanillyl alcohol) yield from 17% to 1%. Based on these results, we propose the reannotation of...”
- The Cellular Response to Lanthanum Is Substrate Specific and Reveals a Novel Route for Glycerol Metabolism in Pseudomonas putida KT2440
Wehrmann, mBio 2020 - “...name Predicted protein function a Fold change (log 2 ) log 10 ( P value) PP_2426 CalA Coniferyl alcohol dehydrogenase 6.28 4.03 PP_2679 PedH Quinoprotein ethanol dehydrogenase 4.75 3.80 PP_3426 MexF Multidrug efflux RND transporter 3.93 3.24 PP_3425 MexE Efflux transporter RND family 3.74 2.18 PP_4921...”
- “...were constructed as follows. The 650-bp to 1,000-bp regions upstream and downstream of the calA (PP_2426), garK (PP_3178), glpFKRD (PP_1076 to PP_1973), and glcDEF (PP_3745 to PP_3747) genes were amplified from genomic DNA of P. putida KT2440 using primer pairs PcalA1/2 and PcalA3/4, PgarK1/2 and PgarK3/4,...”
- Physiological responses of Pseudomonas putida to formaldehyde during detoxification
Roca, Microbial biotechnology 2008 - “...Duque etal. (2007a ) PRCC (PP1974) Excinuclease ABC, B subunit Duque etal. (2007a ) PRCC (PP2426) d isomer specific 2hydroxy acid dehydrogenase Duque etal. (2007a ) PRCC (PP2646) Conserved hypothetical protein Duque etal. (2007a ) PRCC (PP2647) Major facilitator family transporter Duque etal. (2007a ) PRCC...”
- “...etal. , 2005 ). In our assays two 2hydroxy acid dehydrogenase family proteins (PP1616 and PP2426) were induced more than sixfold. Other genes whose expression levels increased more than twofold were the gshA gene (PP0243), whose gene product is involved in the biosynthesis of glutathione; the...”
- “...Y PP_1982 Heatshock protein IbpA ibpA 8.25 2 PP_2302 ATPdependent protease La lon2 2.12 2 PP_2426 d isomer specific 2hydroxy acid dehydrogenase family protein 6.11 3 Y PP_2568 Ringcleaving dioxygenase 2.06 4 PP_2646 Conserved hypothetical protein 2.17 7 Y PP_2647 Major facilitator family transporter 1.85 5...”
- “...dehydrogenase No growth PP_1617 Esterase, putative 8.7 PP_1629 RecA protein 2.8 PP_1974 Uvr B 2.2 PP_2426 d isomer specific 2hydroxy acid dehydrogenase 9.5 PP_2647 Major facilitator family transporter 8.8 PP_2648 Universal stress protein family 8.2 PP_2695 Transcriptional regulator LysR family 2.5 PP_3425 Multidrug efflux RND membrane...”
FEZ21_09870 vanillin reductase from Pseudomonas sp. 9.1(2019)
63% identity, 97% coverage
PAS_chr3_0006 NADPH-dependent medium chain alcohol dehydrogenase from Komagataella phaffii GS115
59% identity, 97% coverage
BPSL0192 NADP-dependent alcohol dehydrogenase from Burkholderia pseudomallei K96243
63% identity, 97% coverage
PSPTO_2697 oxidoreductase, zinc-binding from Pseudomonas syringae pv. tomato str. DC3000
63% identity, 96% coverage
KGF88_00295 NAD(P)-dependent alcohol dehydrogenase from Idiomarina loihiensis
61% identity, 98% coverage
FEZ21_15000 NAD(P)-dependent alcohol dehydrogenase from Pseudomonas sp. 9.1(2019)
58% identity, 96% coverage
NP_386798 PUTATIVE ZINC-TYPE ALCOHOL DEHYDROGENASE PROTEIN from Sinorhizobium meliloti 1021
59% identity, 98% coverage
APA386B_496 NAD(P)-dependent alcohol dehydrogenase from Acetobacter pasteurianus 386B
62% identity, 97% coverage
Gbem_0401 Alcohol dehydrogenase zinc-binding domain protein from Geobacter bemidjiensis Bem
57% identity, 98% coverage
LINJ_23_0410 putative NADP-dependent alcohol dehydrogenase from Leishmania infantum JPCM5
54% identity, 99% coverage
adhA / C0SPA5 S-(hydroxymethyl)bacillithiol dehydrogenase (EC 1.1.1.306) from Bacillus subtilis (strain 168) (see 2 papers)
ADHA_BACSU / C0SPA5 Probable formaldehyde dehydrogenase AdhA; EC 1.1.1.- from Bacillus subtilis (strain 168) (see paper)
NP_390579 putative aldehyde dehydrogenase; carbonyl stress response from Bacillus subtilis subsp. subtilis str. 168
NP_390579 putative dehydrogenase from Bacillus subtilis subsp. subtilis str. 168
53% identity, 98% coverage
Q4QBD8 Putative NADP-dependent alcohol dehydrogenase from Leishmania major
54% identity, 99% coverage
Atu2022 NADP-dependent alcohol dehydrogenase from Agrobacterium tumefaciens str. C58 (Cereon)
55% identity, 98% coverage
BMD_3473 zinc-binding dehydrogenase family oxidoreductase from Bacillus megaterium DSM319
53% identity, 97% coverage
- Metabolic Rearrangements Causing Elevated Proline and Polyhydroxybutyrate Accumulation During the Osmotic Adaptation Response of Bacillus megaterium
Godard, Frontiers in bioengineering and biotechnology 2020 - “...and Supplementary Table 2 ). Finally, several oxidoreductases (BMD_0912, BMD_0989, BMD_1041, BMD_2681, BMD_3119, BMD_3139, BMD_3288, BMD_3473, BMD_3493), peptidases and proteases (BMD_0331, InhA, BMD_3039, PepQ, BMD_4817, CtpB, BMD_5202) were also part of this core group of proteins and their increased concentrations positively contributed to a reduction of...”
GSU3125 alcohol dehydrogenase, zinc-containing from Geobacter sulfurreducens PCA
59% identity, 93% coverage
- Cobalt Resistance via Detoxification and Mineralization in the Iron-Reducing Bacterium Geobacter sulfurreducens
Dulay, Frontiers in microbiology 2020 - “...oriented, membrane-bound formate dehydrogenase, b-type cytochrome subunit, putative 2.02 NrfD, polysulfide reductase (PF03916) Inner membrane GSU3125 mtd mannitol dehydrogenase 2.90 Zn II -binding dehydrogenase (PF00107) Cytoplasm Energy metabolism (2) GSU1640 cydA cytochrome bd menaquinol oxidase, subunit I 3.13 Cytochrome bd terminal oxidase subunit I (PF01654) Inner...”
- Silica immobilization of Geobacter sulfurreducens for constructing ready-to-use artificial bioelectrodes
Estevez-Canales, Microbial biotechnology 2018 - “...GSU2373 WHy domaincontaining lipoprotein. Response to desiccation 6,01 GSU2374 Lytic transglycosylase lipoprotein. Cellular component 5,1 GSU3125 Mannitol dehydrogenase 4,88 mdt GSU1142 Scaffold protein CheW associated with MCPs. Signal transduceractivity 4,74 cheW34H1 GSU0663 PeptidyltRNA hydrolase. Aa translation 4,57 pth G5U1336 TerC family integral protein membrane 4,51 GSU0966...”
- “...of compatible solutes such as amino acids (GSU0151, GSU1607, GSU2371, GSU0153, GSU2874) and sugar alcohol (GSU3125), which were overexpressed between 4.8 and threefold. Another bacterial common response to environmental changes, including osmotic stress, is the modification of the membrane composition (Zhang and Rock, 2008 ). Silica...”
- DNA microarray analysis of nitrogen fixation and Fe(III) reduction in Geobacter sulfurreducens
Methé, Applied and environmental microbiology 2005 - “...GSU2408 GSU2409 GSU2490 GSU2751 GSU2779 GSU2804 GSU2821 GSU3125 Primer sequence Common name Forward DNA gyrase, B subunit Nickel-dependent hydrogenase, small...”
Psal013_RS16675 NAD(P)-dependent alcohol dehydrogenase from Piscirickettsia salmonis
55% identity, 98% coverage
- Cohabitation of Piscirickettsia salmonis genogroups (LF-89 and EM-90): synergistic effect on growth dynamics
Carril, Frontiers in cellular and infection microbiology 2023 - “...(Psal013_RS16660) with 2.581-fold change, flagellar hook-associated protein FlgK (Psal013_RS06465) with 2.522-fold change, NAD(P)-dependent alcohol dehydrogenase (Psal013_RS16675) with 2.354-fold change, thiol reductant ABC exporter subunit CydD (Psal013_RS11795) with 2.268-fold change, flagellar protein export ATPase FliI (Psal013_RS14360) with 2.22-fold change, and cadherin-like domain-containing protein (Psal013_RS10175) with 2.205-fold change....”
XF1746 alcohol dehydrogenase from Xylella fastidiosa 9a5c
57% identity, 98% coverage
A0A125SUY5 alcohol dehydrogenase (NADP+) (EC 1.1.1.2) from Mycobacterium sp. (see paper)
54% identity, 99% coverage
L2164_13090 NAD(P)-dependent alcohol dehydrogenase from Pectobacterium brasiliense
56% identity, 99% coverage
SGR_6892 putative dehydrogenase from Streptomyces griseus subsp. griseus NBRC 13350
56% identity, 95% coverage
- Structure of an MmyB-like regulator from C. aurantiacus, member of a new transcription factor family linked to antibiotic metabolism in actinomycetes
Xu, PloS one 2012 - “...the transcription of SCO4945. Interestingly, in S. griseus , the orthologs (SGR_6891 for SCO4944 and SGR_6892 for SCO4945) are separated from afsA ( i.e. SGR_6889), which is essential for the synthesis of the -butyrolactone A-factor (2-isocapryloyl-3R-hydroxymethyl-gamma-butyrolactone), by a single gene (SGR_6890). A-factor is a hormone-like signaling...”
- “...and spore formation [34] . Microarray data show that the transcription of both SGR_6891 and SGR_6892 is induced immediately after addition of A-factor to liquid-grown cultures (within 5 min) [35] , suggesting that both genes are part of A-factor regulatory cascade. However, lack of an obvious...”
vnz_22770 NAD(P)-dependent alcohol dehydrogenase from Streptomyces venezuelae
55% identity, 92% coverage
ADHC1_MYCS2 / P0CH36 NADP-dependent alcohol dehydrogenase C 1; Ms-ADHC 1; EC 1.1.1.2 from Mycolicibacterium smegmatis (strain ATCC 700084 / mc(2)155) (Mycobacterium smegmatis) (see 2 papers)
ADHC2_MYCS2 / P0CH37 NADP-dependent alcohol dehydrogenase C 2; Ms-ADHC 2; EC 1.1.1.2 from Mycolicibacterium smegmatis (strain ATCC 700084 / mc(2)155) (Mycobacterium smegmatis) (see 2 papers)
MSMEG_1037 alcohol dehydrogenase, zinc-containing from Mycobacterium smegmatis str. MC2 155
55% identity, 98% coverage
- function: Prefers aldehydes over alcohols
catalytic activity: a primary alcohol + NADP(+) = an aldehyde + NADPH + H(+) (RHEA:15937)
cofactor: Zn(2+) (Binds 2 Zn(2+) ions per subunit.)
disruption phenotype: Not essential for growth, strains missing one copy or both grow slower and have a different morphology than wild- type. - function: Prefers aldehydes over alcohols
catalytic activity: a primary alcohol + NADP(+) = an aldehyde + NADPH + H(+) (RHEA:15937)
cofactor: Zn(2+) (Binds 2 Zn(2+) ions per subunit.)
disruption phenotype: Not essential for growth, strains missing one copy or both grow slower and have a different morphology than wild- type. - Acid stress response of a mycobacterial proteome: insight from a gene ontology analysis
Roxas, International journal of clinical and experimental medicine 2009 (secret)
YahK / b0325 aldehyde reductase, NADPH-dependent (EC 1.1.1.2; EC 1.1.1.55) from Escherichia coli K-12 substr. MG1655 (see 8 papers)
yahK / P75691 aldehyde reductase, NADPH-dependent (EC 1.1.1.2; EC 1.1.1.55) from Escherichia coli (strain K12) (see 7 papers)
YAHK_ECOLI / P75691 Aldehyde reductase YahK; Zinc-dependent alcohol dehydrogenase YahK; EC 1.1.1.2 from Escherichia coli (strain K12) (see 2 papers)
yahK / MB|P75691 zinc-type alcohol dehydrogenase-like protein yahK from Escherichia coli K12 (see paper)
NP_414859 aldehyde reductase, NADPH-dependent from Escherichia coli str. K-12 substr. MG1655
b0325 predicted oxidoreductase, Zn-dependent and NAD(P)-binding from Escherichia coli str. K-12 substr. MG1655
B21_00284 NADPH-dependent aldehyde reductase YahK from Escherichia coli BL21(DE3)
56% identity, 98% coverage
- function: Catalyzes the reduction of a wide range of aldehydes into their corresponding alcohols. Has a strong preference for NADPH over NADH as the electron donor. Cannot use a ketone as substrate. Is a major source of NADPH-dependent aldehyde reductase activity in E.coli. The in vivo functions of YahK has yet to be determined.
catalytic activity: a primary alcohol + NADP(+) = an aldehyde + NADPH + H(+) (RHEA:15937)
cofactor: Zn(2+) (Binds 2 Zn(2+) ions per subunit. {ECO:0000269|PubMed:22094925, ECO:0000269|Ref.)6} - Detection of immunoreactive proteins of Escherichia coli, Streptococcus uberis, and Streptococcus agalactiae isolated from cows with diagnosed mastitis
Dobrut, Frontiers in cellular and infection microbiology 2023 - “...cofactor biosynthesis protein B P0AF00 18768 Cymiddlelasm Other N N Antigen EC_2 Aldehyde reductase YahK P75691 38524 Cymiddlelasm Other N N Antigen EC_3 Outer membrane protein A P0A911 37292 Outer membrane Sec signal peptide predicted. Most likely cleavage site: 1 - 21 [AQA-AP] Y Y Antigen...”
- “...cofactor biosynthesis protein B P0AF00 7 1r2k.1.A 100% 0.96 3 3 EC_2 Aldehyde reductase YahK P75691 13 1uuf.1.A 99.7% 0.95 5 6 EC_3 Outer membrane protein A P0A911 12 3nb3.1.A 99.4% 0.39 3 5 GMQE, Global Model Quality Estimation, calculated after building the model on selected...”
- Early and specific targeted mass spectrometry-based identification of bacteria in endotracheal aspirates of patients suspected with ventilator-associated pneumonia
Bardet, European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology 2021 - “...time: 20.44min); GQAINVQNIYGK (D0C807 UniProtKB accession number; retention time: 15.56min). * 2 E. coli VVAVGDQVEK: (P75691 UniProtKB accession number; retention time: 11.24min); DYVEGETAAK (P0A9Q7 UniProtKB accession number; retention time: 9.76min); WNGVTVTPK (P0ADU5 UniProtKB accession number; retention time: 13.99min). * 3 H. influenzae : YAYVTLGNK (P43839 UniProtKB...”
- Combinatorial modulation of initial codons for improved zeaxanthin synthetic pathway efficiency in Escherichia coli
Wu, MicrobiologyOpen 2019 - “...5phosphate synthase OS= Escherichia coli (strain K12) 38.62064587 16.0494 5 243 26.368 5.95 1.276 25.20745921 P75691 Aldehyde reductase YahK OS= Escherichia coli (strain K12) 35.94943889 14.3266 6 349 37.954 6.23 0.995 24.27691317 P0AB77 2amino3ketobutyrate coenzyme A ligase OS= Escherichia coli 23.08778624 9.79899 4 398 43.09 5.97...”
- “...5phosphate synthase OS= Escherichia coli (strain K12) 65.53282216 16.4609 7 243 26.368 5.95 2.162 39.8662715 P75691 Aldehyde reductase YahK OS= Escherichia coli (strain K12) 57.03702369 23.7822 10 349 37.954 6.23 1.512 45.17795205 P0AB77 2amino3ketobutyrate coenzyme A ligase OS= Escherichia coli 46.90887079 20.603 8 398 43.09 5.97...”
- Energetics-based protein profiling on a proteomic scale: identification of proteins resistant to proteolysis
Park, Journal of molecular biology 2007 - “...agp 391 43.6 5.38 10 P37095 pepB 427 46.2 5.60 11 a P75691 yahK 349 38.0 5.80 12 P00509 aspC 396 43.6 5.54 13 P11665 Pgk 386 41.0 5.08 14 P02928 malE 370 40.7...”
- The Escherichia coli proteome: past, present, and future prospects
Han, Microbiology and molecular biology reviews : MMBR 2006 - “...YaeC YaeH YaeT P37016 P0ACC3 Q9F577 P62768 P0A940 YahK P75691 YajD YajG YajO YajQ YbbL P0AAQ2 P0ADA5 P77735 P0A8E7 P77279 YbbN YbdQ P77395 YbeZ YbfF P0A9K3...”
- Escherichia coli alcohol dehydrogenase YahK is a protein that binds both iron and zinc.
Liang, PeerJ 2024 - GeneRIF: Escherichia coli alcohol dehydrogenase YahK is a protein that binds both iron and zinc.
- Sxy induces a CRP-S regulon in Escherichia coli
Sinha, Journal of bacteriology 2009 - “...77 78 79 79 b3863 b0294 b3334 b0245 b4326 b1562 b0235 b0325 b3554 b4327 b0032 b2821 b2819 polA matA gspM ykfI yjiD hokD ykfJ yahK yiaF yjiE carA ptrA recD 4.18...”
- Reconfiguring the quorum-sensing regulator SdiA of Escherichia coli to control biofilm formation via indole and N-acylhomoserine lactones
Lee, Applied and environmental microbiology 2009 - “...RNA affecting ompF expression Hypothetical yahK yahO ybaS b0325 b0329 b0485 5.7 7.0 7.5 2.6 2.8 2.3 Hypothetical zinc-type alcohol dehydrogenase-like protein...”
- Definition of the Escherichia coli MC4100 genome by use of a DNA array
Peters, Journal of bacteriology 2003 - “...yagC, yagE, yagT, ykfD,a b0331, b0333 eaeH b0323, b0324, b0325, b0350a yagA, yagB, yagJ, yagK, yagP, yagQ, yagR, yagS, yagU, yagV, yagX, yagY, yagZ, yahA, ycfA,...”
- Modular assembly of an artificially concise biocatalytic cascade for the manufacture of phenethylisoquinoline alkaloids
Gao, Nature communications 2024 - “..., accession number: B21_00205 ; yeaE , accession number: B21_01738 ; yahK , accession number: B21_00284 ; yjgB , accession number: B21_04099 and yqhC , accession number: B21_02833 ) were obtained from online software ( https://www.atum.bio/eCommerce/cas9/input ) and ligated to the plasmid pTargetF (Addgene), giving the...”
SCO4945 dehydrogenase from Streptomyces coelicolor A3(2)
55% identity, 93% coverage
MAB_3400 NADP-dependent alcohol dehydrogenase C from Mycobacterium abscessus ATCC 19977
53% identity, 98% coverage
MT3130 NADP-dependent alcohol dehydrogenase from Mycobacterium tuberculosis CDC1551
P0A4X1 NADP-dependent alcohol dehydrogenase C from Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97)
Rv3045 PROBABLE NADP-DEPENDENT ALCOHOL DEHYDROGENASE ADHC from Mycobacterium tuberculosis H37Rv
54% identity, 98% coverage
- REMap: Operon map of M. tuberculosis based on RNA sequence data
Pelly, Tuberculosis (Edinburgh, Scotland) 2016 - “...annotations in the TubercuList database [ 33 ] ( MT3129 encodes an ATP synthase , MT3130 encodes an NADP-dependent alcohol dehydrogenase and MT3131.1 encodes a hypothetical protein), and secondly, the IGR between MT3130 and MT3131.1 contains a gene, MT3131 , in the reverse orientation ( Figure...”
- Oral vaccination with heat inactivated Mycobacterium bovis activates the complement system to protect against tuberculosis
Beltrán-Beck, PloS one 2014 - “...number) Upstream/downsteam primer sequences (5-3) PCR annealing temperature PCR product size (bp) NADP-dependent alcoholdehydrogenase C(NADPAD) (P0A4X1) GGTGGTCATATGAGCACTGTTGCCGCCTAC/GGTGGTTGCTCTTCCGCACAGGGCTGAGATGTCGATGAC 56C 1,041 glyceraldehyde-3-phosphate dehydrogenase(GAPDH) (P64179) GGTGGTCATATGGTGACGGTCCGAGTAGGCATC/GTGGTTGCTCTTCCGCAGAGCGACTTGCCGACCAGCGT 66C 1,023 MPB83 (ACD61707) GGTGGTCATATGATCAACGTTCAGGCCAAA/GGTGGTTGCTCTTCCGCACTGTGCCGGGGGCATCAGCAC 42C 663 Universal stress protein RV2623/MT2698 (NP_337200) GGTGGTCATATGTCATCGGGCAATTCATCT/GGTGGTTGCTCTTCCGCAAGTCAGCGACTCGCGTGCCAC 42C 894 In vitro Experiments In vitro infection and analysis...”
- “...DCs and macrophages [29] . Band 2 was identified as NADP-dependent alcohol dehydrogenase C (NADPAD) (P0A4X1) [30] . Band 3 contained two proteins, MPB83 (ACD61707) and the universal stress protein Rv2623/MT2698 (NP_337200). MPB83 is a secreted glycoprotein with homology to MPB70 [31] , [32] that has...”
- Devising Isolation Forest-Based Method to Investigate the sRNAome of Mycobacterium tuberculosis Using sRNA-seq Data
Maity, Bioinformatics and biology insights 2024 - “...For example, the start site of the sRNA ncRv3045 matched with an internal TSS of Rv3045 ( Figure 5 ). ncRv3045 is conserved in the genomes of M. africanum , M. canettii , M. bovis , M. avium , M. haemophilum , M. leprae , and...”
- “...). Figure 5. TSS-driven synthesis of ncRv3045. sRNA ncRv3045 is located within the CDS of Rv3045 and is detected in all the studied growth conditions except in nutrient starvation. A previously annotated internal TSS (iTSS) located immediately upstream of the ncRv3045 (indicated by the blue vertical...”
- Building a better bacillus: the emergence of Mycobacterium tuberculosis
Wang, Frontiers in microbiology 2014 - “...Rv1894c Rv1894c, Rv2172c Rv2172c, Rv2392 - cysH, Rv2440c - obg, Rv2477c Rv2477c, Rv3019c - esxR, Rv3045 - adhC, Rv3392c - cmaA1, Rv3502c - hsd4A . FIGURE 2 Genomic organization of operons in M. tuberculosis, M. kansasii , and M. marinum. (A) Rv0986-0988 ; (B) Rv3376-3378c ;...”
- Prokaryotic ubiquitin-like protein (Pup) proteome of Mycobacterium tuberculosis [corrected]
Festa, PloS one 2010 - “...LeuD (21.8) 154 Rv1185c FadD21 (62.8) 355 Rv3002c IlvN (18.2) 44 Rv1295 ThrC (37.3) 151 Rv3045 AdhC (37.1) 209 Rv1308 AtpA (59.3) 489 Rv3149 NuoE (27.2) 45 Rv1315 MurA (44.0) 81 Rv3246c MtrA (25.3) 207 Rv1392 MetK (43.0) 345 Rv3248c SahH (54.3) 474 Rv1655 ArgD (40.9)...”
- Quantification of global transcription patterns in prokaryotes using spotted microarrays
Sidders, Genome biology 2007 - “...- 95 Rv3680 Rv3680 765 294 - 96 Rv3457c rpoA 760 293 In vitro 97 Rv3045 adhC 756 272 - 98 Rv1792 Rv1792 753 326 - 99 Rv2969c Rv2969c 738 141 In vitro 100 Rv1177 fdxC 736 303 In vitro 101 Rv3867 Rv3867 735 200 -...”
1uufA / P75691 Crystal structure of a zinc-type alcohol dehydrogenase-like protein yahk
57% identity, 98% coverage
Z0420 putative oxidoreductase from Escherichia coli O157:H7 EDL933
56% identity, 98% coverage
- Activated peritoneal cavity B-1a cells possess regulatory B cell properties
Margry, PloS one 2014 - “...assay (ELISA). 96-well ELISA plates (NUNC Maxisorp) were coated with polyclonal goat anti-mouse immunoglobulins (Dako Z0420). Free binding sites were blocked with a blocking buffer containing 4% horse serum (Gibco) and 1% Tween-80 (Sigma). Sera were diluted in a buffer containing 4% horse serum, 1% Tween-80...”
C5934_08415 NAD(P)-dependent alcohol dehydrogenase from Cronobacter sakazakii
54% identity, 98% coverage
A1R6C3 alcohol dehydrogenase (NADP+) (EC 1.1.1.2) from Paenarthrobacter aurescens (see paper)
AAur_2040 NADP-dependent alcohol dehydrogenase from Arthrobacter aurescens TC1
54% identity, 97% coverage
- Defining lower limits of biodegradation: atrazine degradation regulated by mass transfer and maintenance demand in Arthrobacter aurescens TC1
Kundu, The ISME journal 2019 - “...1.61 0.018 0.82 0.223 A1R7Y1 AAur_2625 Alcohol dehydrogenase 0.55 0.222 0.08 0.849 0.47 0.433 A1R6C3 AAur_2040 Alcohol dehydrogenase 1.76 0.085 1.47 0.104 0.29 0.846 2 A1RDQ5 AAur_pTC20218 Putative alcohol dehydrogenase 2.07 0.007 1.25 0.038 0.82 0.264 A1R953 AAur_3064 Aldehyde dehydrogenase (NAD) 1.93 0.006 2.76 0.005 0.83...”
- Degradation of Swainsonine by the NADP-Dependent Alcohol Dehydrogenase A1R6C3 in Arthrobacter sp. HW08
Wang, Toxins 2016 - “...with or without SW stimulation. Using this assay, we demonstrated that the NADP-dependent alcohol dehydrogenase AAur_2040 played a dominant role in SW degradation. 2. Results 2.1. Degradation of SW by Strain HW08 The strain HW08 was previously isolated and was shown to have the capacity to...”
- “...protein quantification results based on iBAQ intensity ( Figure 4 B). Of note, AAur_1890 , AAur_2040 , and Arth_2986 , which encode A1R5X7, A1R6C3, and A0JZ95, were the most significantly upregulated genes in strain HW08 cells following SW induction ( Figure 4 A,B). Then, we focused...”
- Defining lower limits of biodegradation: atrazine degradation regulated by mass transfer and maintenance demand in Arthrobacter aurescens TC1.
Kundu, The ISME journal 2019 - “...0.132 1.61 0.018 0.82 0.223 A1R7Y1 AAur_2625 Alcohol dehydrogenase 0.55 0.222 0.08 0.849 0.47 0.433 A1R6C3 AAur_2040 Alcohol dehydrogenase 1.76 0.085 1.47 0.104 0.29 0.846 2 A1RDQ5 AAur_pTC20218 Putative alcohol dehydrogenase 2.07 0.007 1.25 0.038 0.82 0.264 A1R953 AAur_3064 Aldehyde dehydrogenase (NAD) 1.93 0.006 2.76 0.005...”
- Degradation of Swainsonine by the NADP-Dependent Alcohol Dehydrogenase A1R6C3 in Arthrobacter sp. HW08.
Wang, Toxins 2016 - “...Toxins 2072-6651 MDPI 4885060 10.3390/toxins8050145 toxins-08-00145 Article Degradation of Swainsonine by the NADP-Dependent Alcohol Dehydrogenase A1R6C3 in Arthrobacter sp. HW08 Wang Yan 1 * Zhai Aguan 1 Zhang Yanqi 1 Qiu Kai 2 Wang Jianhua 1 Li Qinfan 1 * Shaw Pang-Chui Academic Editor 1 College...”
- “...sugar phosphate isomerase/epimerase A1R5X7, Acetyl-CoA acetyltransferase A0JZ95, and nicotinamide adenine dinucleotide phosphate (NADP)-dependent alcohol dehydrogenase A1R6C3 were found to contribute to the swainsonine degradation. Notably, NADP-dependent alcohol dehyrodgenase A1R6C3 appeared to play a major role in degrading swainsonine, but not as much as Arthrobacter sp. HW08...”
A1S_1788 Zn-dependent alcohol dehydrogenase from Acinetobacter baumannii ATCC 17978
62% identity, 74% coverage
- Molecular mechanisms of ethanol-induced pathogenesis revealed by RNA-sequencing
Camarena, PLoS pathogens 2010 - “...expression is not induced by ethanol. Other genes that may encode additional ethanol dehydrogenases are A1S_1788 and A1S_3436. We observed a slight induction of A1S_1788 by ethanol, but it showed a p-value higher than the selected cutoff ( Table 2 ). Therefore, under our experimental conditions,...”
- “...ethanol to acetate by the activity of the enzymes encoded by A1S_2098, A1S_2102 and perhaps A1S_1788 ( Fig. 2 ). 10.1371/journal.ppat.1000834.g002 Figure 2 Metabolic pathways affected by the presence of ethanol. The numbers in parenthesis represent the ratio of the number of gene-specific mapped reads from...”
C1M2W0 Somatic embryogenesis cinnamyl alcohol dehydrogenase 1 from Cucumis sativus
51% identity, 96% coverage
- Quantitative proteomics identifies 38 proteins that are differentially expressed in cucumber in response to cucumber green mottle mosaic virus infection
Liu, Virology journal 2015 - “...subunit K, chloroplastic GO:0051234, GO:0008152 BP 0.7 GO:0009534 CC GO:0043169, GO:0051536 GO:0048037, GO:0050136 MF 12 C1M2W0 Cinnamyl alcohol dehydrogenase GO:0008152 BP 0.7 GO:0016616, GO:0046914 MF 13 Q2QD76 Apocytochrome f GO:0051234, GO:0006091 BP 0.6 GO:0009534, GO:0016021 CC GO:0005506 MF 14 Q84V66 Galactinol synthase - - 0.6 15...”
- “...inoculation (1, 10 and 30 dpi). The levels of several proteins including P08216, Q4VZI6, Q4VZH2, C1M2W0, A4GWU2, B1PE19, Q8RW69, P19135, P29602, A1BQL5 and Q5DJS5 were found to decline, while the levels of Q4VZK4 and O04379 were found to increase. Other proteins were found to exhibit more...”
LOC110744673 probable cinnamyl alcohol dehydrogenase 9 from Prunus avium
52% identity, 95% coverage
- Resistance analysis of cherry rootstock 'CDR-1' (Prunus mahaleb) to crown gall disease
Liang, BMC plant biology 2020 - “...Pav_sc0000636.1_g260.1.mk, LOC110758567), PmCYP450 (ID: Pav_sc0001248.1_g320.1.mk, LOC110766184), PmHCT1 (Pav_sc0002792.1_g140.1.br, LOC110774309), PmHCT2 (Pav_sc0002792.1_g150.1.mk, LOC103335795), and PmCAD (Pav_sc0004014.1_g160.1.mk, LOC110744673) screened from P. mahaleb were the DEGs in the phenylpropanoid biosynthesis pathway. Next, we measured the lignin content of plants infected with A. tumefaciens . This generally became elevated over...”
A1R7Y1 alcohol dehydrogenase (NADP(+)) from Paenarthrobacter aurescens (strain TC1)
AAur_2625 putative Zinc-containing alcohol dehydrogenase from Arthrobacter aurescens TC1
55% identity, 90% coverage
LOC18036047 probable mannitol dehydrogenase from Citrus x clementina
52% identity, 95% coverage
O82035 Probable cinnamyl alcohol dehydrogenase 2 from Picea abies
47% identity, 96% coverage
T1WUT6 cinnamyl-alcohol dehydrogenase (EC 1.1.1.195) from Populus tomentosa (see paper)
51% identity, 96% coverage
LT85_RS01775 NAD(P)-dependent alcohol dehydrogenase from Collimonas arenae
51% identity, 97% coverage
CADH6_ARATH / O65621 Probable cinnamyl alcohol dehydrogenase 6; AtCAD6; Cinnamyl alcohol dehydrogenase-like protein A; EC 1.1.1.195 from Arabidopsis thaliana (Mouse-ear cress) (see 2 papers)
AT4G37970 CAD6 (CINNAMYL ALCOHOL DEHYDROGENASE 6); binding / catalytic/ oxidoreductase/ zinc ion binding from Arabidopsis thaliana
NP_195510 cinnamyl alcohol dehydrogenase 6 from Arabidopsis thaliana
48% identity, 96% coverage
- function: Involved in lignin biosynthesis. Catalyzes the final step specific for the production of lignin monomers. Catalyzes the NADPH- dependent reduction of coniferaldehyde, 5-hydroxyconiferaldehyde, sinapaldehyde, 4-coumaraldehyde and caffeyl aldehyde to their respective alcohols.
catalytic activity: (E)-cinnamyl alcohol + NADP(+) = (E)-cinnamaldehyde + NADPH + H(+) (RHEA:10392)
catalytic activity: (E)-coniferol + NADP(+) = (E)-coniferaldehyde + NADPH + H(+) (RHEA:22444)
catalytic activity: (E)-sinapyl alcohol + NADP(+) = (E)-sinapaldehyde + NADPH + H(+) (RHEA:45704)
catalytic activity: (E)-4-coumaroyl alcohol + NADP(+) = (E)-4-coumaraldehyde + NADPH + H(+) (RHEA:45724)
catalytic activity: (E)-caffeyl alcohol + NADP(+) = (E)-caffeyl aldehyde + NADPH + H(+) (RHEA:45728)
cofactor: Zn(2+) (Binds 2 Zn(2+) ions per subunit.)
subunit: Homodimer. - Modification of xylan in secondary walls alters cell wall biosynthesis and wood formation programs and improves saccharification
Sivan, Plant biotechnology journal 2025 - “...0.58 0.91 10c20411 Potri.010G224100 PtPAL4 AT2G37040 AtPAL1 0.50 1.08 0.57 0.85 Lignin biosynthesis 16c29966 Potri.016G078300 AT4G37970 AtCAD6 0.47 0.51 0.59 0.62 1c2649 Potri.001G304800 PtCCoAOMT2 AT4G34050 AtCCoAOMT1 0.55 1.15 0.56 0.60 9c19246 Potri.009G099800 PtCCoAOMT1 AT4G34050 AtCCoAOMT1 0.39 0.77 0.38 0.56 3c6783 Potri.003G188500 Pt4CL5 AT1G51680 At4CL1 1.00 1.80...”
- Effect of thermospermine on expression profiling of different gene using massive analysis of cDNA ends (MACE) and vascular maintenance in Arabidopsis
Sagor, Physiology and molecular biology of plants : an international journal of functional plant biology 2021 - “...The genes, encoding cinnamyl-alcohol dehydrogenase (At4g37970, At2g21890, At2g21730), HXXXD-type acyl transferase (At5g38130, At1g32910, At5g42830, At4g31910),...”
- CAD Genes: Genome-Wide Identification, Evolution, and Their Contribution to Lignin Biosynthesis in Pear (Pyrus bretschneideri)
Qi, Plants (Basel, Switzerland) 2021 - “..., 25 September 2019). Nine CAD protein sequences of Arabidopsis (AT1G72680, AT2G21730, AT2G21890, AT3G19450, AT4G34230, AT4G37970, AT4G37980, AT4G37990, and AT4G39330) were downloaded from The Arabidopsis Information Resource ( http://www.arabidopsis.org/ , 25 September 2019) and used as queries to perform a BLAST search against the four Rosaceae...”
- Involvement of the R2R3-MYB transcription factor MYB21 and its homologs in regulating flavonol accumulation in Arabidopsis stamen
Zhang, Journal of experimental botany 2021 - “...promoters of other genes encoding enzymes involved in the phenylpropanoid pathway, such as CAD6 ( AT4G37970 ), F5H ( AT4G36220 ), and CCoAoMT ( AT4G34050 ), which is responsible for lignin monolignol biosynthesis ( Weng et al. 2010 ). The defect in lignified thickening leads to...”
- Comparative Analyses of Phyllosphere Bacterial Communities and Metabolomes in Newly Developed Needles of Cunninghamia lanceolata (Lamb.) Hook. at Four Stages of Stand Growth
Sun, Frontiers in plant science 2021 - “...1(4CL1) (at3g21230 and at1g20500), elicitor-activated gene 3-2 (ELI3-2) (at4g37990 and at4g37980), and cinnamyl alcohol dehydrogenase (at4g37970, at4g34230, at4g34230, and at2g21730). In SM35, more than half of DEGs were down-regulated compared with SM15 ( Supplementary Table 3 ). Discussion Analysis of Chinese Fir Phyllosphere Bacterial Communities at...”
- Using Gene Expression to Study Specialized Metabolism-A Practical Guide
Delli-Ponti, Frontiers in plant science 2020 - “...We entered the 14 ( AT2G37040, AT3G10340, AT3G53260, AT5G04230, AT2G30490, AT1G72680, AT2G21730, AT2G21890, AT3G19450, AT4G34230, AT4G37970, AT4G37980, AT4G37990 , and AT4G39330 ) genes into the Tools/Heatmap/Comparative 2 , which revealed the expression profiles of these genes in organs of Arabidopsis . The resulting heatmap was pasted...”
- GbMYBR1 from Ginkgo biloba represses phenylpropanoid biosynthesis and trichome development in Arabidopsis
Su, Planta 2020 - “...2.5 5.00E-05 Cytochrome P450, family 79, subfamily B, polypeptide 3 AT4G34135 2.4 5.00E-05 UDP-glucosyltransferase 73B2 AT4G37970 2.4 0.00155 Cinnamyl alcohol dehydrogenase 6 (CAD) AT5G04230 2.3 5.00E-05 Phenylalanine ammonia-lyase 3 (PAL) AT4G38620 2.3 5.00E-05 Myb domain protein 4 AT3G50740 2.2 5.00E-05 UDP-glucosyl transferase 72E1 AT1G51680 2.2 5.00E-05...”
- The dynamic response of the Arabidopsis root metabolome to auxin and ethylene is not predicted by changes in the transcriptome
Hildreth, Scientific reports 2020 - “...0.33 0.30 0.29 CAD-like AT1G30760 264527_at 0.00 0.00 0.31 1.58 2.52 4.32 4.52 3.50 CAD6 AT4G37970 253017_at 0.19 0.46 0.89 0.18 0.77 0.84 0.79 0.88 CAD8 AT4G39330 252943_at 0.03 0.12 0.31 0.20 0.15 0.33 0.66 1.50 Flavonoid CHS AT5G13930 250207_at 0.34 0.53 0.36 0.33 0.45 0.72...”
- More
- Physcomitrium patens CAD1 has distinct roles in growth and resistance to biotic stress
Jiang, BMC plant biology 2022 - “...Accession number of proteins used to build the tree are: Arabidopsis thaliana AtCAD1 (NP_195643); AtCAD2 (NP_195510); AtCAD3(CAA48027); AtCAD4 (NP_195512); AtCAD5 (NP_188576); AtCAD6 (NP_195149); AtCAD7 (NP_179765); AtCAD8 (NP_179780); AtCAD9 (NP_177412); Populus tremuloides PtCAD1 (AAF43140); PtCAD2 (AAK58693);PtCAD3 (AAK58693); PtCAD4 (AAK58693); PtCAD5 (AAK58693); PtCAD6 (AAK58693); PtCAD7 (AAK58693); PtCAD8 (AAK58693)...”
- Genome-wide identification of the CAD gene family and functional analysis of putative bona fide CAD genes in tobacco (Nicotiana tabacum L.)
Wu, Frontiers in plant science 2024 - “...(Ntab, Ntom, and Nsyl); Arabidopsis thaliana , AtCAD19 (accession number: Q9CAI3, Q9SJ25, Q9SJ10, P48523, O49482, O65621, Q02971, Q02972, P42734); Oryza sativa , OsCAD19 (Q8H859, Q6ZHS4, Q337Y2, Q2R114, Q0J6T3, Q7XWU3, Q0JA75, Q6ERX1, Q10PS6); Brachypodium distachyon , BdCAD3 (AFK80371), BdCAD5 (AFK80372); Triticum aestivum , TaCAD1 (GU563724); Elaeis guineensis...”
- Polysaccharide Fraction Extracted from Endophytic Fungus Trichoderma atroviride D16 Has an Influence on the Proteomics Profile of the Salvia miltiorrhiza Hairy Roots
Peng, Biomolecules 2019 - “...reductase family 4 member C8 2.65 1.56 Q42306 Ribulose bisphosphate carboxylase small chain (Fragment) 12.36 O65621 Probable cinnamyl alcohol dehydrogenase 6 1.85 2.69 Transport protein Q84VY3 Acyl-[acyl-carrier-protein] desaturase 6, chloroplastic 0.66 Q56WK6 Patellin-1 0.65 0.57 Q9SA89 FAD-binding and BBE domain-containing protein 2.25 1.67 Q9SRU2 Auxin transport...”
A0A023RBJ1 cinnamyl-alcohol dehydrogenase (EC 1.1.1.195) from Populus tomentosa (see paper)
51% identity, 95% coverage
D7U461 Enoyl reductase (ER) domain-containing protein from Vitis vinifera
50% identity, 95% coverage
Q8L7U8 Putative sinapyl alcohol dehydrogenase from Populus tremula x Populus tremuloides
51% identity, 96% coverage
- Transcriptomic and metabolite analyses of Cabernet Sauvignon grape berry development.
Deluc, BMC genomics 2007 - “...2.1 1609147_at CB979150 TC55437 Q645N0 Malate dehydrogenase (cytosolic) Organic Acid 11 2.01 1607417_at CF512464 TC53733 Q8L7U8 Cinnamyl-alcohol dehydrogenase CAD1 Phenolic Acid 2 80.03 1614643_at CF214966 TC51729 Q43237 Caffeoyl-CoA O-Methyltransferase Phenolic Acid 2 34.34 1611265_at CF513719 TC51900 Q49LX7 4-coumarate:CoA ligase Phenolic Acid 11 25.11 1620342_at CF207053 TC64352...”
F6L7F5 cinnamyl-alcohol dehydrogenase (EC 1.1.1.195) from Camellia sinensis (see paper)
51% identity, 96% coverage
T1WWR8 cinnamyl-alcohol dehydrogenase (EC 1.1.1.195) from Populus tomentosa (see paper)
51% identity, 96% coverage
G7JFC2 Cinnamyl alcohol dehydrogenase-like protein from Medicago truncatula
51% identity, 96% coverage
LOC101293136 probable mannitol dehydrogenase from Fragaria vesca subsp. vesca
52% identity, 96% coverage
- The mechanism of abscisic acid regulation of wild Fragaria species in response to cold stress
Shen, BMC genomics 2022 - “...LOC101304511, LOC101313880, LOC101300079, LOC101311471, LOC101295227, LOC101293925, LOC101306855, LOC101291993, LOC101303901, LOC101304719, LOC101305686, LOC105349241, LOC101305018, LOC101294010, LOC101297378, LOC101293136, LOC101314462, LOC101296126, and LOC105351650 (Fig. 4 a). These genes may play roles in amino acid metabolism. Choline dehydrogenase (CHDH) can catalyze choline, an intermediate product of glycine, serine, and threonine...”
LOC101297378 probable mannitol dehydrogenase from Fragaria vesca subsp. vesca
52% identity, 96% coverage
- The mechanism of abscisic acid regulation of wild Fragaria species in response to cold stress
Shen, BMC genomics 2022 - “...including LOC101304511, LOC101313880, LOC101300079, LOC101311471, LOC101295227, LOC101293925, LOC101306855, LOC101291993, LOC101303901, LOC101304719, LOC101305686, LOC105349241, LOC101305018, LOC101294010, LOC101297378, LOC101293136, LOC101314462, LOC101296126, and LOC105351650 (Fig. 4 a). These genes may play roles in amino acid metabolism. Choline dehydrogenase (CHDH) can catalyze choline, an intermediate product of glycine, serine, and...”
LOC101510334 probable mannitol dehydrogenase from Cicer arietinum
51% identity, 96% coverage
- Metabolomics and Molecular Approaches Reveal Drought Stress Tolerance in Plants
Kumar, International journal of molecular sciences 2021 - “...R. soongorica Increased flavonoids and anthocyanin Drought, UV-B radiation [ 199 ] Mannitol dehydrogenase (CaMTD) LOC101510334 Cicer arietinum C. arietinum Increased flavonoids Drought [ 200 ] Mannitol-1-phosphate dehydrogenase ( EcmtlD ) EFF7369098 Escherichia coli T. aestivum Increased mannitol Drought [ 201 ] Ornithine - aminotransferase (...”
D7TRU0 Enoyl reductase (ER) domain-containing protein from Vitis vinifera
51% identity, 94% coverage
LOC101305018 probable mannitol dehydrogenase from Fragaria vesca subsp. vesca
51% identity, 96% coverage
- The mechanism of abscisic acid regulation of wild Fragaria species in response to cold stress
Shen, BMC genomics 2022 - “...significantly upregulated, including LOC101304511, LOC101313880, LOC101300079, LOC101311471, LOC101295227, LOC101293925, LOC101306855, LOC101291993, LOC101303901, LOC101304719, LOC101305686, LOC105349241, LOC101305018, LOC101294010, LOC101297378, LOC101293136, LOC101314462, LOC101296126, and LOC105351650 (Fig. 4 a). These genes may play roles in amino acid metabolism. Choline dehydrogenase (CHDH) can catalyze choline, an intermediate product of glycine,...”
Q9ZRF1 Probable mannitol dehydrogenase from Fragaria ananassa
51% identity, 96% coverage
LOC101253340 8-hydroxygeraniol dehydrogenase-like from Solanum lycopersicum
50% identity, 95% coverage
T1WWB9 cinnamyl-alcohol dehydrogenase (EC 1.1.1.195) from Populus tomentosa (see paper)
51% identity, 96% coverage
Q9ATW1 cinnamyl-alcohol dehydrogenase (EC 1.1.1.195) from Fragaria x ananassa (see paper)
51% identity, 96% coverage
- Grapevine cell early activation of specific responses to DIMEB, a resveratrol elicitor.
Zamboni, BMC genomics 2009 - “...Caffeoyl-CoA O-methyltransferase Q8H9B6 TC63685 x 1614643_at Caffeoyl-CoA O-methyltransferase Q43237 TC51729 x 1613900_at Cinnamyl alcohol dehydrogenase Q9ATW1 TC52904 x 1614045_at Ferulate 5-hydroxylase Q6IV45 TC64493 x 1614502_at Ferulate 5-hydroxylase Q6IV45 TC63764 x 1619065_at Putative cinnamoyl-CoA reductase Q8W3H0 TC53437 x 1622651_at Polyphenol oxidase Q68NI4 TC58764 x 1610806_at Putative diphenol...”
- Transcriptomic and metabolite analyses of Cabernet Sauvignon grape berry development.
Deluc, BMC genomics 2007 - “...9.32 1614423_at CF517687 TC66815 Q6DMZ8 Cinnamoyl CoA Reductase Phenolic Acid 2 8.61 1620650_s_at CF207485 TC69704 Q9ATW1 Cinnamyl-alcohol dehydrogenase Phenolic Acid 1 5.95 1616191_s_at CB971061 TC70715 Q3HM04 Cinnamate-4-Hydroxylase Phenolic Acid 3 5.78 1613542_at CF209028 TC62584 Q7X9J0 O-methyltransferase Phenolic Acid 2 5.54 1622267_at CF516149 TC64537 O65152 Cinnamyl-alcohol dehydrogenase...”
- “...metabolism 2 4.28 1622065_at CD801714 - Q94FA7 Fructose-bisphosphatase Carbohydrate metabolism 3 4.17 1622503_at CF203022 TC69704 Q9ATW1 Mannitol dehydrogenase Carbohydrate metabolism 1 4.16 1615634_at CB970085 TC69016 Q8L9U9 Glucose acyltransferase Carbohydrate metabolism 12 3.86 1607324_at CD719348 TC54773 P94078 a-mannosidase Carbohydrate metabolism 2 3.85 1611112_at CB971308 TC51885 Q7XPW5 Phosphomannomutase...”
CADH3_ARATH / Q9SJ10 Cinnamyl alcohol dehydrogenase 3; AtCAD3; EC 1.1.1.195 from Arabidopsis thaliana (Mouse-ear cress) (see 3 papers)
NP_179780 cinnamyl alcohol dehydrogenase homolog 3 from Arabidopsis thaliana
AT2G21890 CAD3 (CINNAMYL ALCOHOL DEHYDROGENASE HOMOLOG 3); binding / catalytic/ oxidoreductase/ zinc ion binding from Arabidopsis thaliana
49% identity, 91% coverage
- function: Involved in lignin biosynthesis. Catalyzes the final step specific for the production of lignin monomers. Catalyzes the NADPH- dependent reduction of coniferaldehyde, 5-hydroxyconiferaldehyde, sinapaldehyde, 4-coumaraldehyde and caffeyl aldehyde to their respective alcohols.
catalytic activity: (E)-cinnamyl alcohol + NADP(+) = (E)-cinnamaldehyde + NADPH + H(+) (RHEA:10392)
catalytic activity: (E)-coniferol + NADP(+) = (E)-coniferaldehyde + NADPH + H(+) (RHEA:22444)
catalytic activity: (E)-sinapyl alcohol + NADP(+) = (E)-sinapaldehyde + NADPH + H(+) (RHEA:45704)
catalytic activity: (E)-4-coumaroyl alcohol + NADP(+) = (E)-4-coumaraldehyde + NADPH + H(+) (RHEA:45724)
catalytic activity: (E)-caffeyl alcohol + NADP(+) = (E)-caffeyl aldehyde + NADPH + H(+) (RHEA:45728)
cofactor: Zn(2+) (Binds 2 Zn(2+) ions per subunit.)
subunit: Homodimer. - Physcomitrium patens CAD1 has distinct roles in growth and resistance to biotic stress
Jiang, BMC plant biology 2022 - “...thaliana AtCAD1 (NP_195643); AtCAD2 (NP_195510); AtCAD3(CAA48027); AtCAD4 (NP_195512); AtCAD5 (NP_188576); AtCAD6 (NP_195149); AtCAD7 (NP_179765); AtCAD8 (NP_179780); AtCAD9 (NP_177412); Populus tremuloides PtCAD1 (AAF43140); PtCAD2 (AAK58693);PtCAD3 (AAK58693); PtCAD4 (AAK58693); PtCAD5 (AAK58693); PtCAD6 (AAK58693); PtCAD7 (AAK58693); PtCAD8 (AAK58693) PtCAD9 (AAK58693); Oryza sativa OsCAD1 (DAA02237); OsCAD2 (DAA02237); OsCAD3 (DAA02237); OsCAD4...”
- Genome-wide identification of the CAD gene family and functional analysis of putative bona fide CAD genes in tobacco (Nicotiana tabacum L.)
Wu, Frontiers in plant science 2024 - “...study include tobacco (Ntab, Ntom, and Nsyl); Arabidopsis thaliana , AtCAD19 (accession number: Q9CAI3, Q9SJ25, Q9SJ10, P48523, O49482, O65621, Q02971, Q02972, P42734); Oryza sativa , OsCAD19 (Q8H859, Q6ZHS4, Q337Y2, Q2R114, Q0J6T3, Q7XWU3, Q0JA75, Q6ERX1, Q10PS6); Brachypodium distachyon , BdCAD3 (AFK80371), BdCAD5 (AFK80372); Triticum aestivum , TaCAD1...”
- The Ralstonia pseudosolanacearum Type III Effector RipL Delays Flowering and Promotes Susceptibility to Pseudomonas syringae in Arabidopsis thaliana
Kim, Molecules and cells 2023 - “..., and At1g26450 expression was clearly up-regulated while At4g08160 , At5g48920 , At2g05440 , and At2g21890 expression was down-regulated in the two RipL-expressing lines compared to WT, in accordance with the respective transcript per million (TPM) values detected by RNA sequencing. RipL expression dampens the overall...”
- Effect of thermospermine on expression profiling of different gene using massive analysis of cDNA ends (MACE) and vascular maintenance in Arabidopsis
Sagor, Physiology and molecular biology of plants : an international journal of functional plant biology 2021 - “...genes, encoding cinnamyl-alcohol dehydrogenase (At4g37970, At2g21890, At2g21730), HXXXD-type acyl transferase (At5g38130, At1g32910, At5g42830, At4g31910),...”
- CAD Genes: Genome-Wide Identification, Evolution, and Their Contribution to Lignin Biosynthesis in Pear (Pyrus bretschneideri)
Qi, Plants (Basel, Switzerland) 2021 - “...Rosaceae ( http://www.rosaceae.org/ , 25 September 2019). Nine CAD protein sequences of Arabidopsis (AT1G72680, AT2G21730, AT2G21890, AT3G19450, AT4G34230, AT4G37970, AT4G37980, AT4G37990, and AT4G39330) were downloaded from The Arabidopsis Information Resource ( http://www.arabidopsis.org/ , 25 September 2019) and used as queries to perform a BLAST search against...”
- The bacterial biocontrol agent Paenibacillus alvei K165 confers inherited resistance to Verticillium dahliae
Gkizi, Journal of experimental botany 2021 - “...designed in Primer-BLAST (Ye. et al ., 2012) and, for the amplification of CAD3 ( At2g21890 ), a primer set published by Raes et al. (2003) was used. Normalization of gene expression, PCR efficiency, absence of non-specific products and primer dimers, and data analysis were performed...”
- Transcriptomic Changes in Internode Explants of Stinging Nettle during Callogenesis
Xu, International journal of molecular sciences 2021 - “...C2 ( Dataset S1 ); orthologs of thale cress CAD1 and CAD3 ( At1g72680 and At2g21890 , corresponding to contig_1059 and contig_4205, respectively, with log2FC 10D vs. 0D > 3.5), as well as PAL1 ( At2g37040 , contig_4482), which almost doubled in expression at 10D compared...”
- Using Gene Expression to Study Specialized Metabolism-A Practical Guide
Delli-Ponti, Frontiers in plant science 2020 - “...the CAD family. We entered the 14 ( AT2G37040, AT3G10340, AT3G53260, AT5G04230, AT2G30490, AT1G72680, AT2G21730, AT2G21890, AT3G19450, AT4G34230, AT4G37970, AT4G37980, AT4G37990 , and AT4G39330 ) genes into the Tools/Heatmap/Comparative 2 , which revealed the expression profiles of these genes in organs of Arabidopsis . The resulting...”
- A Transcriptomic Analysis of Xylan Mutants Does Not Support the Existence of a Secondary Cell Wall Integrity System in Arabidopsis
Faria-Blanc, Frontiers in plant science 2018 - “...0.02 0.05 0.02 0.01 0 0.03 CAD1 AT1G72680 1.33 0.21 0.07 0.09 0.14 0.01 CAD3 AT2G21890 2.37 1.36 0.03 0.03 0.12 0.13 CAD4 AT3G19450 2.05 0.48 0.06 0.04 0.05 0.46 CAD5 AT4G34230 0.49 0.08 0.2 0.06 0.03 0.15 CAD6 AT4G37970 0.16 0.11 0.12 0.11 0.29 0.1...”
- Functional metabolomics as a tool to analyze Mediator function and structure in plants
Davoine, PloS one 2017 - “...WT ( Fig 3A3C ; S3 S6 Tables). Accordingly, several genes (At4g36220, At1g15950, At3g21560, At1g80820, At2g21890) encoding enzymes in the sinapoyl ester pathway were up-regulated in med18 ( S7 Table ). SA compounds can be produced both by the isochorismate and phenylpropanoid pathways and phenylalanine is...”
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Q5I6D6 Sinapyl alcohol dehydrogenase-like protein from Populus tremula x Populus tremuloides
49% identity, 94% coverage
- Transcriptomic and metabolite analyses of Cabernet Sauvignon grape berry development.
Deluc, BMC genomics 2007 - “...3 3.96 1611249_s_at CF517155 TC51769 O65152 Cinnamyl-alcohol dehydrogenase Phenolic Acid 3 3.93 1613831_at CD801016 TC58955 Q5I6D6 Sinapyl alcohol dehydrogenase Phenolic Acid 3 3.36 1613548_at CB009193 TC68990 Q8H8C9 4-coumarate:CoA ligase Phenolic Acid 11 3.19 1615439_at CF213244 TC63112 P30359 Cinnamyl alcohol dehydrogenase 2 Phenolic Acid 2 2.38 1609327_at...”
CADH9_ARATH / P42734 Probable cinnamyl alcohol dehydrogenase 9; AtCAD9; EC 1.1.1.195 from Arabidopsis thaliana (Mouse-ear cress) (see 2 papers)
AT4G39330 CAD9 (CINNAMYL ALCOHOL DEHYDROGENASE 9); binding / catalytic/ oxidoreductase/ zinc ion binding from Arabidopsis thaliana
NP_195643 cinnamyl alcohol dehydrogenase 9 from Arabidopsis thaliana
47% identity, 96% coverage
- function: Involved in lignin biosynthesis. May catalyze the final step specific for the production of lignin monomers, like coniferyl alcohol, sinapyl alcohol and 4-coumaryl alcohol.
catalytic activity: (E)-cinnamyl alcohol + NADP(+) = (E)-cinnamaldehyde + NADPH + H(+) (RHEA:10392)
cofactor: Zn(2+) (Binds 2 Zn(2+) ions per subunit.)
subunit: Homodimer. - NTRC and thioredoxins m1/m2 underpin the light acclimation of plants on proteome and metabolome levels
Dziubek, Plant physiology 2024 - “...names Location AT1G76680 12-oxophytodienoate reductase 1 cytosol AT3G24503 Aldehyde dehydrogenase family 2 member C4 cytosol AT4G39330 Probable cinnamyl alcohol dehydrogenase 9 cytosol AT1G17990 Putative 12-oxophytodienoate reductase-like protein 2A cytosol AT1G79440 Succinate-semialdehyde dehydrogenase mitochondrion AT2G45770 Cell division protein FtsY homolog plastid AT5G21430 NAD(P)H-quinone oxidoreductase subunit U plastid...”
- OAF is a DAF-like gene that controls ovule development in plants
Li, Communications biology 2023 - “...Among the OAF-interacting proteins identified (Supplementary Table 1 ), a cinnamyl alcohol dehydrogenase 9 (CAD9) (At4g39330) gene specifically expressed in ovules was further characterized. CAD9 belongs to a CAD multigene family with nine genes in Arabidopsis (Supplementary Fig. 7 ), which have been thought to be...”
- “...2 . Construction of 35S:: CAD9 construct cDNA containing the open reading frames of CAD9 (At4G39330) was amplified by RT-PCR using the 5 primer AtCAD9-F and the 3 primer AtCAD9-R for CAD9 . The primers contained the Pst I (5-CTGCAG-3) or Sal I (5-GTCGAC-3) recognition site...”
- The tomato chloroplast stromal proteome compendium elucidated by leveraging a plastid protein-localization prediction Atlas
Bhattacharya, Frontiers in plant science 2023 - “...At1g10700 Secondary metabolism Solyc05g056540 ADH1B Alcohol dehydrogenase-like protein At5g63620 Solyc08g014360 CAD6 Cinnamyl alcohol dehydrogenase-like protein At4g39330 Solyc01g105890 TPS5 (MTS1) Linalool synthase At3g25810 Solyc06g005720 Tropinone-reductase-like39 At2g29260 Miscellaneous Solyc04g073990 ANN1 Annexin At1g35720 Solyc03g115110 ATP synthase gamma chain At2g33040 Solyc04g007550 ATP synthase subunit beta At5g08680 Solyc02g086880 FNADH1 Formate dehydrogenase...”
- Diverse Effect of Two Cytokinins, Kinetin and Benzyladenine, on Plant Development, Biotic Stress Tolerance, and Gene Expression
Bozsó, Life (Basel, Switzerland) 2021 - “...such as a glucose-methanol-choline (GMC) oxidoreductase-like gene (AT1G12570) and putative cinnamyl alcohol dehydrogenase 9 genes (AT4G39330). In addition, among the most suppressed genes by only kinetin treatment was a proline dehydrogenase 2 gene (AT5G38710). BA repressed allene oxide cyclase 1 (AT3G25760). Naturally, we could separate the...”
- CAD Genes: Genome-Wide Identification, Evolution, and Their Contribution to Lignin Biosynthesis in Pear (Pyrus bretschneideri)
Qi, Plants (Basel, Switzerland) 2021 - “...Nine CAD protein sequences of Arabidopsis (AT1G72680, AT2G21730, AT2G21890, AT3G19450, AT4G34230, AT4G37970, AT4G37980, AT4G37990, and AT4G39330) were downloaded from The Arabidopsis Information Resource ( http://www.arabidopsis.org/ , 25 September 2019) and used as queries to perform a BLAST search against the four Rosaceae genome databases. Additionally, the...”
- Comparative transcriptomics revealed differential regulation of defense related genes in Brassica juncea leading to successful and unsuccessful infestation by aphid species
Duhlian, Scientific reports 2020 - “...ACS45170 at4g25700 3.51 Beta-hydroxylase1 (BETA-OHASE1) Lignin biosynthesis AAG14961 at4g36220 2.32 Ferulic acid 5-hydroxylase1 (FAH1) ESQ53188 at4g39330 2.82 Cinnamyl alcohol dehydrogenase9 (CAD9) ADC40029 at1g15950 2.03 Cinnamoyl coA reductase1 (CCR1) ESQ33074 at2g02400 2 Cinnamoyl-CoA reductase family Glucosinolate biosynthesis ACR10244 at3g19710 2.32 Branched-chain aminotransferase4 (BCAT4) AAL09350 at1g24100 2.44 UDP-glucosyl...”
- “...2.1 Isoflavone reductase, putative Carotenoid biosynthesis AGZ62518 at1g06820 3.24 Carotenoid isomerase (CRTISO) Lignin biosynthesis ESQ53188 at4g39330 3.77 Cinnamyl alcohol dehydrogenase9 (CAD9) NP_177876 at1g77520 2.36 O-methyltransferase family 2 protein Glucosinolate breakdown CAA79989 at5g26000 2.03 Thioglucoside glucohydrolase1 (TGG1) ESQ51834 at2g33070 4.99 Nitrile specifier protein2 (NSP2) Several transcripts showing...”
- Using Gene Expression to Study Specialized Metabolism-A Practical Guide
Delli-Ponti, Frontiers in plant science 2020 - “...AT2G37040, AT3G10340, AT3G53260, AT5G04230, AT2G30490, AT1G72680, AT2G21730, AT2G21890, AT3G19450, AT4G34230, AT4G37970, AT4G37980, AT4G37990 , and AT4G39330 ) genes into the Tools/Heatmap/Comparative 2 , which revealed the expression profiles of these genes in organs of Arabidopsis . The resulting heatmap was pasted into the ClustVis web-tool 3...”
- Proximal and Distal Parts of Sweetpotato Adventitious Roots Display Differences in Root Architecture, Lignin, and Starch Metabolism and Their Developmental Fates
Singh, Frontiers in plant science 2020 - “...Lignin biosynthesis S_PBL_lrc53688 Cinnamyl alcohol dehydrogenase ( IbCAD ) Firon et al., 2013 ; GU380306 AT4G39330 Cinnamyl alcohol dehydrogenase ( CAD ) Sibout et al., 2005 Lignin biosynthesis Class I knotted 1-like S_PBL_c8137 Class I knotted1-like homeobox (KNOX1) ( IbKN2 ) Firon et al., 2013 ;...”
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- Physcomitrium patens CAD1 has distinct roles in growth and resistance to biotic stress
Jiang, BMC plant biology 2022 - “...protein family. Accession number of proteins used to build the tree are: Arabidopsis thaliana AtCAD1 (NP_195643); AtCAD2 (NP_195510); AtCAD3(CAA48027); AtCAD4 (NP_195512); AtCAD5 (NP_188576); AtCAD6 (NP_195149); AtCAD7 (NP_179765); AtCAD8 (NP_179780); AtCAD9 (NP_177412); Populus tremuloides PtCAD1 (AAF43140); PtCAD2 (AAK58693);PtCAD3 (AAK58693); PtCAD4 (AAK58693); PtCAD5 (AAK58693); PtCAD6 (AAK58693); PtCAD7 (AAK58693);...”
- Genome-wide identification of the CAD gene family and functional analysis of putative bona fide CAD genes in tobacco (Nicotiana tabacum L.)
Wu, Frontiers in plant science 2024 - “...Nsyl); Arabidopsis thaliana , AtCAD19 (accession number: Q9CAI3, Q9SJ25, Q9SJ10, P48523, O49482, O65621, Q02971, Q02972, P42734); Oryza sativa , OsCAD19 (Q8H859, Q6ZHS4, Q337Y2, Q2R114, Q0J6T3, Q7XWU3, Q0JA75, Q6ERX1, Q10PS6); Brachypodium distachyon , BdCAD3 (AFK80371), BdCAD5 (AFK80372); Triticum aestivum , TaCAD1 (GU563724); Elaeis guineensis , EgCAD1 (UTE99576),...”
- Proteomic Analysis of Proteins Related to Defense Responses in Arabidopsis Plants Transformed with the rolB Oncogene
Vereshchagina, International journal of molecular sciences 2023 - “...Fatty acid biosynthesis 2.5 14 P52410 3-oxoacyl-[acyl-carrier-protein] synthase I, chloroplastic Fatty acid biosynthesis 1.5 15 P42734 Probable cinnamyl alcohol dehydrogenase 9 Lignin biosynthesis 1.7 16 O64767 AICARFT/IMPCHase bienzyme family protein Purine biosynthesis 1.5 17 Q96533 Alcohol dehydrogenase class-3 Ethanol oxidation; formaldehyde catabolic process 1.6 18 Q949Y0...”
- iTRAQ-Based Proteomic Analysis Reveals Potential Regulation Networks of IBA-Induced Adventitious Root Formation in Apple
Lei, International journal of molecular sciences 2018 - “...82.41 8.7 4 1.57 MDP0000221713 Aldehyde dehydrogenase Q9SU63 82.05 18.4 7 2 MDP0000236430 Alcohol dehydrogenases P42734 66.77 8.6 4 1.78 MDP0000267169 Fructose-1,6-bisphosphatase P46283 75.31 4.9 1 2.07 MDP0000273014 Fructose-1,6-bisphosphatase P46275 78.87 19.5 6 1.67 MDP0000244771 Fructose-1,6-bisphosphatase P46283 83.72 5.8 3 1.57 MDP0000277811 Fructose-1,6-bisphosphatase P46283 80.67 5...”
- Proteomic analysis of anthers from wild-type and photosensitive genetic male sterile mutant cotton (Gossypium hirsutum L.)
Liu, BMC plant biology 2014 - “...0.85 1.82 1.45 _ 4 85 Cotton_D_gene_10036599 Probable cinnamyl alcohol dehydrogenase 9 96.6 39.57/5.67 22.84% P42734 79.89 2.24 2.11 3.47 _ 3 Protein folding and assembly 20 Cotton_A_13598 23.6kDa heat shock protein 220 23.48/5.22 55.77% Q96331 62.15 1.55 NDS - M 5 59 Cotton_A_16089 Protein disulfide-isomerase...”
LOC101304719 uncharacterized protein LOC101304719 from Fragaria vesca subsp. vesca
50% identity, 42% coverage
- Transcriptomic and Metabolomic Analyses Provide Insights into the Formation of the Peach-like Aroma of Fragaria nilgerrensis Schlecht. Fruits
Wang, Genes 2022 - “...lactones. The four structural genes significantly correlated with -octalactone were FAD (LOC101307465), AOS (LOC101312801), ADH (LOC101304719), and a cytochrome P450 family member (LOC101305403); the correlation was positive for ADH ( Figure 10 a, Table S6 ). The five structural genes significantly correlated with -decalactone were FAD...”
- The mechanism of abscisic acid regulation of wild Fragaria species in response to cold stress
Shen, BMC genomics 2022 - “...19 DEGs were significantly upregulated, including LOC101304511, LOC101313880, LOC101300079, LOC101311471, LOC101295227, LOC101293925, LOC101306855, LOC101291993, LOC101303901, LOC101304719, LOC101305686, LOC105349241, LOC101305018, LOC101294010, LOC101297378, LOC101293136, LOC101314462, LOC101296126, and LOC105351650 (Fig. 4 a). These genes may play roles in amino acid metabolism. Choline dehydrogenase (CHDH) can catalyze choline, an intermediate...”
T1WUU2 cinnamyl-alcohol dehydrogenase (EC 1.1.1.195) from Populus tomentosa (see paper)
49% identity, 94% coverage
Q1HGA8 cinnamyl-alcohol dehydrogenase (EC 1.1.1.195) from Linum usitatissimum (see 3 papers)
45% identity, 96% coverage
SAD / Q94G59 sinapyl alcohol dehydrogenase (EC 1.1.1.195) from Populus tremuloides (see paper)
49% identity, 94% coverage
O82515 Probable mannitol dehydrogenase from Medicago sativa
50% identity, 97% coverage
- Genome-wide identification of the CAD gene family and functional analysis of putative bona fide CAD genes in tobacco (Nicotiana tabacum L.)
Wu, Frontiers in plant science 2024 - “...aestivum , TaCAD1 (GU563724); Elaeis guineensis , EgCAD1 (UTE99576), EgCAD (XP_010943210); Medicago sativa , MsCAD1 (O82515), MsCAD2 (P31656); Morus alba , MaCAD15 (UZH97791, UZH97792, UZH97793, UZH97794, UZH97795); Picea abies , PaCAD1 (CAA05097); Populus tremuloides , PtCAD (AAF43140); Pinus taeda , PtaCAD (CAA86073); Populus tomentosa , PtoCAD1,...”
LOC105110689 8-hydroxygeraniol dehydrogenase-like from Populus euphratica
49% identity, 94% coverage
CADH2_ARATH / Q9SJ25 Cinnamyl alcohol dehydrogenase 2; AtCAD2; EC 1.1.1.195 from Arabidopsis thaliana (Mouse-ear cress) (see 3 papers)
AT2G21730 cinnamyl alcohol dehydrogenase homolog 2 from Arabidopsis thaliana
NP_179765 CAD2 (CINNAMYL ALCOHOL DEHYDROGENASE HOMOLOG 2); binding / catalytic/ oxidoreductase/ zinc ion binding from Arabidopsis thaliana
48% identity, 91% coverage
- function: Involved in lignin biosynthesis. Catalyzes the final step specific for the production of lignin monomers. Catalyzes the NADPH- dependent reduction of coniferaldehyde, 5-hydroxyconiferaldehyde, sinapaldehyde, 4-coumaraldehyde and caffeyl aldehyde to their respective alcohols.
catalytic activity: (E)-cinnamyl alcohol + NADP(+) = (E)-cinnamaldehyde + NADPH + H(+) (RHEA:10392)
catalytic activity: (E)-coniferol + NADP(+) = (E)-coniferaldehyde + NADPH + H(+) (RHEA:22444)
catalytic activity: (E)-sinapyl alcohol + NADP(+) = (E)-sinapaldehyde + NADPH + H(+) (RHEA:45704)
catalytic activity: (E)-4-coumaroyl alcohol + NADP(+) = (E)-4-coumaraldehyde + NADPH + H(+) (RHEA:45724)
catalytic activity: (E)-caffeyl alcohol + NADP(+) = (E)-caffeyl aldehyde + NADPH + H(+) (RHEA:45728)
cofactor: Zn(2+) (Binds 2 Zn(2+) ions per subunit.)
subunit: Homodimer. - Effect of thermospermine on expression profiling of different gene using massive analysis of cDNA ends (MACE) and vascular maintenance in Arabidopsis
Sagor, Physiology and molecular biology of plants : an international journal of functional plant biology 2021 - “...encoding cinnamyl-alcohol dehydrogenase (At4g37970, At2g21890, At2g21730), HXXXD-type acyl transferase (At5g38130, At1g32910, At5g42830, At4g31910), acyl-CoA...”
- CAD Genes: Genome-Wide Identification, Evolution, and Their Contribution to Lignin Biosynthesis in Pear (Pyrus bretschneideri)
Qi, Plants (Basel, Switzerland) 2021 - “...for Rosaceae ( http://www.rosaceae.org/ , 25 September 2019). Nine CAD protein sequences of Arabidopsis (AT1G72680, AT2G21730, AT2G21890, AT3G19450, AT4G34230, AT4G37970, AT4G37980, AT4G37990, and AT4G39330) were downloaded from The Arabidopsis Information Resource ( http://www.arabidopsis.org/ , 25 September 2019) and used as queries to perform a BLAST search...”
- Comparative Analyses of Phyllosphere Bacterial Communities and Metabolomes in Newly Developed Needles of Cunninghamia lanceolata (Lamb.) Hook. at Four Stages of Stand Growth
Sun, Frontiers in plant science 2021 - “...elicitor-activated gene 3-2 (ELI3-2) (at4g37990 and at4g37980), and cinnamyl alcohol dehydrogenase (at4g37970, at4g34230, at4g34230, and at2g21730). In SM35, more than half of DEGs were down-regulated compared with SM15 ( Supplementary Table 3 ). Discussion Analysis of Chinese Fir Phyllosphere Bacterial Communities at Four Stand Ages The...”
- Using Gene Expression to Study Specialized Metabolism-A Practical Guide
Delli-Ponti, Frontiers in plant science 2020 - “...of the CAD family. We entered the 14 ( AT2G37040, AT3G10340, AT3G53260, AT5G04230, AT2G30490, AT1G72680, AT2G21730, AT2G21890, AT3G19450, AT4G34230, AT4G37970, AT4G37980, AT4G37990 , and AT4G39330 ) genes into the Tools/Heatmap/Comparative 2 , which revealed the expression profiles of these genes in organs of Arabidopsis . The...”
- De novo transcriptome sequencing of black pepper (Piper nigrum L.) and an analysis of genes involved in phenylpropanoid metabolism in response to Phytophthora capsici
Hao, BMC genomics 2016 - “...0.39 9.833996 HCT CL1656 .contig4.ALL At5g48930 0.61 0.1 0.16 91.92 50.1 40.05 7.26238 CAD CL1837.contig3.ALL At2g21730 84.99 74.45 59.41 26.64 28.62 41.55 1.646749 CCR CL215.contig4.ALL At1g15950 235.92 0 0 0 0 0.21 8.855204 C4H CL300.contig10.ALL At2g30490 1.36 0.31 0.32 3.07 3.9 8.35 1.17463 PAL CL4018.contig4.ALL At2g37040...”
- Use of heat stress responsive gene expression levels for early selection of heat tolerant cabbage (Brassica oleracea L.)
Park, International journal of molecular sciences 2013 - “...lignin biosynthesis. COMT at5g54160 ATOMT1 (O-METHYLTRANSFERASE1) X_1039499 X_1039499 2.54 3.09 16.2.1.10 phenylpropanoids. lignin biosynthesis. CAD at2g21730 CAD2 (CINNAMYL ALCOHOL DEHYDROGENASE HOMOLOG 2) B_1059602 B_1046994 2.25 2.15 B_1046994 B_1059602 2.15 2.32 16.4.1 N misc. alkaloid-like at4g28680 TYRDC1 (tyrosine decarboxylase, putative) X_1033105 - 2.39 - B_1077763 - 2.31...”
- A genomewide analysis of the cinnamyl alcohol dehydrogenase family in sorghum [Sorghum bicolor (L.) Moench] identifies SbCAD2 as the brown midrib6 gene
Saballos, Genetics 2009 - “...Arabidopsis thaliana AtCAD1 (At1g72680), AtCAD2 (At2g21730), AtCAD3 (At2g21890), AtCAD4 (At3g19450), AtCAD5 (At4g34230), AtCAD6 (At4g37970), AtCAD7 (At4g37980),...”
- Transcriptomic analysis of Arabidopsis developing stems: a close-up on cell wall genes
Minic, BMC plant biology 2009 - “...of three CAD genes ( CAD1 , At4g39330 ; CAD6 , At4g34230 ; CAD7 , At2g21730 ) decreased during the transition from young elongating stems to mature stems. Only CAD2 ( At3g19450 ) and CAD6 have been shown to play major role in lignification [ 61...”
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- Genome-wide identification of the CAD gene family and functional analysis of putative bona fide CAD genes in tobacco (Nicotiana tabacum L.)
Wu, Frontiers in plant science 2024 - “...this study include tobacco (Ntab, Ntom, and Nsyl); Arabidopsis thaliana , AtCAD19 (accession number: Q9CAI3, Q9SJ25, Q9SJ10, P48523, O49482, O65621, Q02971, Q02972, P42734); Oryza sativa , OsCAD19 (Q8H859, Q6ZHS4, Q337Y2, Q2R114, Q0J6T3, Q7XWU3, Q0JA75, Q6ERX1, Q10PS6); Brachypodium distachyon , BdCAD3 (AFK80371), BdCAD5 (AFK80372); Triticum aestivum ,...”
- Physcomitrium patens CAD1 has distinct roles in growth and resistance to biotic stress
Jiang, BMC plant biology 2022 - “...are: Arabidopsis thaliana AtCAD1 (NP_195643); AtCAD2 (NP_195510); AtCAD3(CAA48027); AtCAD4 (NP_195512); AtCAD5 (NP_188576); AtCAD6 (NP_195149); AtCAD7 (NP_179765); AtCAD8 (NP_179780); AtCAD9 (NP_177412); Populus tremuloides PtCAD1 (AAF43140); PtCAD2 (AAK58693);PtCAD3 (AAK58693); PtCAD4 (AAK58693); PtCAD5 (AAK58693); PtCAD6 (AAK58693); PtCAD7 (AAK58693); PtCAD8 (AAK58693) PtCAD9 (AAK58693); Oryza sativa OsCAD1 (DAA02237); OsCAD2 (DAA02237); OsCAD3...”
- De novo transcriptome analysis of white teak (Gmelina arborea Roxb) wood reveals critical genes involved in xylem development and secondary metabolism
Yaya, BMC genomics 2021 - “...leaves (CADL). Other CAD protein sequences used were: Ath: Arabidopsis thaliana CAD1 (OAP16446.1) and CAD2 (NP_179765), Egr: Eucalyptus grandis (XP_010024064.1) , Jcu: Jatropha curcas (XP_012086572.1), Jre: Juglans regia (XP_018827699.1), Lp: Lolium perenne (AAB70908), Ote: Ocimum tenuiflorum (ADO16245.1), Os: Oryza sativa (Q6ZHS4), Pni: Populus nigra (AFR37935.1), Pto:...”
- Ancient origin of the biosynthesis of lignin precursors
Labeeuw, Biology direct 2015 - “...possible, proteins that have been biochemically characterized were used as queries. These protein sequences [NCBI: NP_179765, NCBI: NP_188576, NCBI: NP_173872, NCBI: NP_001077697, NCBI: NP_173047, NCBI: NP_181241, NCBI: NP_180607, NCBI: NP_199704, NCBI: NP_200227, NCBI: NP_850337, NCBI: NP_195345, NCBI: XP_002963471, NCBI: AAB09228, NCBI: XP_002992167] were used to query...”
1yqdA / Q94G59 Sinapyl alcohol dehydrogenase complexed with NADP+ (see paper)
49% identity, 95% coverage
- Ligands: zinc ion; nadp nicotinamide-adenine-dinucleotide phosphate (1yqdA)
Q337Y2 Probable cinnamyl alcohol dehydrogenase 3 from Oryza sativa subsp. japonica
LOC4348690 probable cinnamyl alcohol dehydrogenase 3 from Oryza sativa Japonica Group
49% identity, 94% coverage
- Genome-wide identification of the CAD gene family and functional analysis of putative bona fide CAD genes in tobacco (Nicotiana tabacum L.)
Wu, Frontiers in plant science 2024 - “...Q9CAI3, Q9SJ25, Q9SJ10, P48523, O49482, O65621, Q02971, Q02972, P42734); Oryza sativa , OsCAD19 (Q8H859, Q6ZHS4, Q337Y2, Q2R114, Q0J6T3, Q7XWU3, Q0JA75, Q6ERX1, Q10PS6); Brachypodium distachyon , BdCAD3 (AFK80371), BdCAD5 (AFK80372); Triticum aestivum , TaCAD1 (GU563724); Elaeis guineensis , EgCAD1 (UTE99576), EgCAD (XP_010943210); Medicago sativa , MsCAD1 (O82515),...”
- iTRAQ based proteomic analysis of rice lines having single or stacked blast resistance genes: Pi54/Pi54rh during incompatible interaction with Magnaporthe oryzae
Kumari, Physiology and molecular biology of plants : an international journal of functional plant biology 2023 - “...were upregulated; while two loci of dehydrogenases (Q337Y2, A3A3Y3) were downregulated. In case of two-gene-stacked TPS-22; single locus of...”
- SWATH-MS-based quantitative proteomics reveals a uniquely intricate defense response in Cnaphalocrocis medinalis-resistant rice
Cheah, Scientific reports 2020 - “...induced in leaves upon herbivorous attack 16 . Consistent with this study, a probable CAD3 (Q337Y2) was downregulated in Qingliu compared with TN1 at 6h of insect herbivory but upregulated in Qingliu compared with TN1 at 72h of insect herbivory. Several major subclasses of flavonoids, namely,...”
- Genome-Wide Analysis of Potassium Channel Genes in Rice: Expression of the OsAKT and OsKAT Genes under Salt Stress
Musavizadeh, Genes 2021 - “...identified as co-expressed genes involved in glycerophospholipid metabolism. In node D, LOC4336497 (salutaridine reductase) and LOC4348690 (probable cinnamyl alcohol dehydrogenase 3) were identified as co-expressed with the K+ channel gene LOC4328864 in monoterpenoid biosynthesis. In node C, two genes, LOC4326296 (light-mediated development protein DET1) and LOC4352424...”
T1WVG5 cinnamyl-alcohol dehydrogenase (EC 1.1.1.195) from Populus tomentosa (see paper)
48% identity, 96% coverage
T1WW77 cinnamyl-alcohol dehydrogenase (EC 1.1.1.195) from Populus tomentosa (see paper)
49% identity, 96% coverage
M5WB20 Enoyl reductase (ER) domain-containing protein from Prunus persica
49% identity, 97% coverage
K9S0X0 geraniol dehydrogenase (NADP+) (EC 1.1.1.183) from Perilla frutescens var. hirtella (see paper)
49% identity, 98% coverage
XP_019169368 probable cinnamyl alcohol dehydrogenase 1 from Ipomoea nil
44% identity, 96% coverage
- Anther dehiscence is regulated by gibberellic acid in yellow lupine (Lupinus luteus L.)
Marciniak, BMC plant biology 2021 - “...(XP_025620500); Ad - Arachis duranensis (XP_015941997); Ai - Arachis ipaensis (XP_016175492); In - Ipomoea nil (XP_019169368); Mt - Medicago truncatula (XP_013470061); Cc - Cajanus cajan (XP_020210039); At - Arabidopsis thaliana (AAK44076). Fig. S1 d. Comparison of CAD proteins derived from different plant species (BlastP) using the...”
- “...(XP_025620500); Ad - Arachis duranensis (XP_015941997); Ai - Arachis ipaensis (XP_016175492); In - Ipomoea nil (XP_019169368); Mt - Medicago truncatula (XP_013470061); Cc - Cajanus cajan (XP_020210039); At - Arabidopsis thaliana (AAK44076). Fig. S2 a. LlCesA8 (alternative name LlIRX1) cDNA (GenBank accession number MW240677, 3788bp) identified in...”
5z0cA / J7JYU1 Nerol dehydrogenase from persicaria minor (see paper)
50% identity, 95% coverage
LOC110941024 probable cinnamyl alcohol dehydrogenase 6 from Helianthus annuus
47% identity, 91% coverage
- Dissecting the Genetic Architecture of Morphological Traits in Sunflower (Helianthus annuus L.)
Delen, Genes 2024 - “...regulator 2, regulating root gravitropic bending and TMK-dependent rapid auxin signaling (LOC110920267); CADH6, biosynthesizing lignin (LOC110941024); and extensin-like, playing a role on physical characteristics of the plant cell wall (LOC110943450). The others detected by farmCPU were as follows: aquaporin PIP2-7, leading the transport of water across...”
- “...the response of the plant immune system (LOC110918080); CADH6, participating in the biosynthesis of lignin (LOC110941024); extensin-like (LOC110943450), having an impact on the physical properties of the plant cell wall. Some other proteins of the genes identified by farmCPU method were as follows: cold-responsive protein kinase...”
CCO1660 probable alcohol dehydrogenase (NADP) Cj1548c from Campylobacter coli RM2228
45% identity, 96% coverage
- Differences in the Transcriptomic Response of Campylobacter coli and Campylobacter lari to Heat Stress
Riedel, Frontiers in microbiology 2020 - “...Down-regulated Energy production and conversion aspA , cydA , hydA2 , ldh , CCO0259, CCO0482, CCO1660 fliI Amino acid transport and metabolism bisZ , dapA , glnA , hisH , potA , proB , serB , CCO1002, CCO1668 ilvE , proC , CCO0338, CCO0845, CCO0846, CCO1354,...”
B5AR58 cinnamyl-alcohol dehydrogenase (EC 1.1.1.195) from Leucaena leucocephala (see paper)
46% identity, 96% coverage
GEDH1 / Q2KNL6 geraniol dehydrogenase (EC 1.1.1.183) from Ocimum basilicum (see paper)
GEDH1_OCIBA / Q2KNL6 Geraniol dehydrogenase 1; ObaGEDH1; EC 1.1.1.183 from Ocimum basilicum (Sweet basil) (see paper)
Q2KNL6 geraniol dehydrogenase (NADP+) (EC 1.1.1.183) from Ocimum basilicum (see paper)
50% identity, 94% coverage
- function: Involved in the production of citral, a mixture of geranial and neral with a strong lemony scent. Reversibly oxidizes geraniol and nerol in equal efficiency. Also active, although at a lower efficiency, with cinnamyl alcohol.
catalytic activity: (2E)-geraniol + NADP(+) = (2E)-geranial + NADPH + H(+) (RHEA:14521)
cofactor: Zn(2+) - Characterization of 10-hydroxygeraniol dehydrogenase from Catharanthus roseus reveals cascaded enzymatic activity in iridoid biosynthesis
Krithika, Scientific reports 2015 - “...Populus trichocarpa (Genbank ID: ACC63874 15 ) and geraniol dehydrogenase from Ocimum basilicum (GenBank ID: Q2KNL6 16 ), was identified as Cr10HGO (KF561458). Deduced amino acid sequence of Cr10HGO was found to have a calculated molecular weight of 38.9kDa, comprising zinc binding alcohol dehydrogenase signature sequence...”
K9RZL7 geraniol dehydrogenase (NADP+) (EC 1.1.1.183) from Perilla frutescens var. hirtella (see paper)
49% identity, 96% coverage
K9S1J6 geraniol dehydrogenase (NADP+) (EC 1.1.1.183) from Perilla frutescens (see paper)
49% identity, 96% coverage
CJE1719 oxidoreductase, zinc-binding dehydrogenase family from Campylobacter jejuni RM1221
46% identity, 96% coverage
- Extensive characterization of Campylobacter jejuni chicken isolates to uncover genes involved in the ability to compete for gut colonization
Thibodeau, BMC microbiology 2015 - “...1 restriction system variant HsdS 0.039 0.857 0.007 0.221 0.279 type 1 restriction system variant CJE1719 0.039 0.213 0.069 0.025 0.008 Zinc-binding dehydrogenase family variant C8J0988 0.043 0.514 0.026 0.127 0.013 Hypothetical protein In the characterized C. jejuni strain collection, strains positive by microarray for these...”
- “...0.015 0.068 0.041 Putative permease cfr A 0.030 0.677 0.008 0.218 0.233 Ferric receptor cfrA CJE1719 0.039 0.213 0.069 0.025 0.008 Zinc-binding dehydrogenase family oxidoreductase variant In the characterized C. jejuni strain collection, strains positive by microarray for these genes had lower mean rank values then...”
LOC18037214 8-hydroxygeraniol dehydrogenase from Citrus x clementina
47% identity, 94% coverage
- Transcriptome analysis of the pulp of citrus fruitlets suggests that domestication enhanced growth processes and reduced chemical defenses increasing palatability
Perez-Roman, Frontiers in plant science 2022 - “...alkaloid biosynthesis. These upregulated steps are geraniol 8-hydroxylase (5 genes out of 6), 8-hydroxygeraniol dehydrogenase (LOC18037214), the dehydrogenase involved in the biosynthesis of oxogeranial from hydroxygeraniol and 7-deoxyloganetin glucosyltransferase (LOC18042369), an iridoid glucosyltransferase involved in the synthesis of secologanin, one of the major intermediates in the...”
- “...LOC112100740 Probable caffeine synthase 4 Caffeine Up Alkaloids LOC18036840 Codeine O -demethylase Morphine Up Alkaloids LOC18037214 8-Hydroxygeraniol dehydrogenase Vinblastine Up Alkaloids LOC18042369 7-Deoxyloganetin glucosyltransferase Secologanin Up Alkaloids LOC18043348; LOC18046227 tyrosine/DOPA decarboxylase 5 Serotonin Down Alkaloids LOC18041681 Tryptamine 5-hydroxylase (CYP71P1) Serotonin Down Alkaloids LOC18043348; LOC18046227 Tyrosine/DOPA decarboxylase...”
- Combined Transcriptome and Metabolome Analyses Reveal Candidate Genes Involved in Tangor (Citrus reticulata × Citrus sinensis) Fruit Development and Quality Formation
Bi, International journal of molecular sciences 2022 - “...generally down-regulated throughout fruit development and ripeningtwo CAD9 (LOC18036047, LOC18040966), PAL2 (LOC18043571), CCoAOMT (LOC18055676), CAD6 (LOC18037214), HCT (LOC18035960), and EMB3009 (LOC18032863). Additionally, a phenylpropane related gene VS (LOC18037906) was up-regulated during S1 to S2 and down-regulated during S2 to S3. For the flavonoid metabolic pathway, 31...”
Q8S411 cinnamyl-alcohol dehydrogenase from Lolium perenne
48% identity, 94% coverage
A0A1D6BJ11 cinnamyl-alcohol dehydrogenase (EC 1.1.1.195) from Triticum aestivum (see paper)
47% identity, 94% coverage
NCgl0324 furfural detoxificationalcohol dehydrogenase FudC from Corynebacterium glutamicum ATCC 13032
cg0400 alcohol dehydrogenase, class C from Corynebacterium glutamicum ATCC 13032
46% identity, 99% coverage
- Vanillin production by Corynebacterium glutamicum using heterologous aromatic carboxylic acid reductases
Matsuzawa, Biotechnology for biofuels and bioproducts 2024 - “...glutamicum as the host owing to its high vanillin resistance. The aromatic aldehyde reductase gene (NCgl0324) and vanillic acid demethylase protein subunits A and B gene ( vanAB , NCgl2300-NCgl2301) were deleted in C. glutamicum genome to avoid vanillin degradation. Next, we searched for an aromatic...”
- “...from 4-hydroxybenzoate using Corynebacterium glutamicum [ 8 ] . They showed that the deletion of NCgl0324 in C. glutamicum decreased vanillyl alcohol production to 27% of that of the parent strain but did not reach 0%. In addition, more PC aldehydes were produced than vanillic acid...”
- Genetic Engineering Approaches for the Microbial Production of Vanillin
Santos, Biomolecules 2024 - “...Figure 13 (A4)). Vanillin could only be produced when the genes vdh , vanAB, and NCgl0324 (encoding a putative aromatic aldehyde reductase) were also deleted to prevent vanillin degradation [ 111 ]. Recently, Mo and Yuan [ 112 ] explored, in a S. cerevisiae MARE strain,...”
- “...gdh1 glutamate dehydrogenase I; gpp1 glycerol-1-phosphatese; MAREmultiple-aldehyde reductases; metJ transcription regulator of methionine biosynthetic cluster; NCgl0324 aromatic aldehyde reductase; pcaHG protocatechuate dioxygenase; pdc1 pyruvate decarboxylase; serA phosphoglycerate dehydrogenase; RAREmultiple-aldehyde reductases; trpE anthranilate synthase; csm chorismate mutase; vdh vanillin dehydrogenase; vanAB vanillate demethylase. List of endogenous genes...”
- Minimal aromatic aldehyde reduction (MARE) yeast platform for engineering vanillin production
Mo, Biotechnology for biofuels and bioproducts 2024 - “...[ 18 ]. Jin-Ho Lee et al . identified that a single gene knockout of NCgl0324 in Corynebacterium glutamicum could substantially improve the production of protocatechualdehyde (PCAL) and vanillin [ 19 ]. High-level vanillin production not only requires a reduced aldehyde reduction, but also an optimal...”
- Strategies for improving the production of bio-based vanillin
Liu, Microbial cell factories 2023 - “...the genes encoding them. To this end, genome mining was conducted in Corynebacterium glutamicum and NCgl0324 was characterized as the enzyme with aromatic aldehyde reductase activity [ 32 ]. Knocking out the corresponding gene led to a titer of 0.31g/L vanillin in the recombinant chassis. Similarly,...”
- Engineered Corynebacterium glutamicum as the Platform for the Production of Aromatic Aldehydes
Kim, Frontiers in bioengineering and biotechnology 2022 - “...that were used in comprehensive screening with a 4-hydroxybenzyl (4-HB) alcoholproducing strain. We identified that NCgl0324 has aromatic aldehyde reductase activity and contributed to 4-HB aldehyde reduction in vivo since the NCgl0324 deletion strain HB- 0324 produced 1.36g/L of 4-HB aldehyde, that is, about 188% more...”
- “...strain that produces protocatechuate was engineered from 4-hydroxybenzoate-synthesizing C. glutamicum APS963, followed by deletion of NCgl0324 to generate PV- 0324 . The PC aldehyde/alcohol or vanillin/vanillyl alcohol biosynthetic pathways, respectively, were able to be expanded from protocatechuate upon introduction of carboxylic acid reductase (CAR) and catechol...”
- High-yield production of L-serine through a novel identified exporter combined with synthetic pathway in Corynebacterium glutamicum
Zhang, Microbial cell factories 2020 - “...ABC transporter permease NCgl2942 283.52 1776.15 6.26 NADH:flavin oxidoreductase NCgl0166 13.41 79.70 5.94 Hypothetical protein NCgl0324 2.11 11.87 5.61 Zn-dependent alcohol dehydrogenase NCgl0282 5.19 28.25 5.44 4-Hydroxyphenyl-beta-ketoacyl-CoA hydrolase NCgl1975 102.94 503.75 4.89 Hypothetical protein NCgl2893 1.25 6.08 4.84 Efflux system protein NCgl0155 9.11 43.69 4.79 5-Dehydro-2-deoxygluconokinase...”
- Utilization of orange peel waste for sustainable amino acid production by Corynebacterium glutamicum
Junker, Frontiers in bioengineering and biotechnology 2024 - “...the medium. One NADPH-specific dehydrogenase contributing to furfural detoxification was identified to be encoded by cg0400 (designated as fudC ) ( Tsuge et al., 2016 ); however, crude extract of the deletion strain still had furfural dehydrogenase activity under both NADPH and NADH consumption. C. glutamicum...”
- C1 metabolism in Corynebacterium glutamicum: an endogenous pathway for oxidation of methanol to carbon dioxide
Witthoff, Applied and environmental microbiology 2013 - “...the genome of C. glutamicum (43): cg0273, cg0387 (adhE), cg0400 (adhC), and cg2714. Their expression levels were not altered in the presence of methanol. To...”
- The alcohol dehydrogenase gene adhA in Corynebacterium glutamicum is subject to carbon catabolite repression
Arndt, Journal of bacteriology 2007 - “...cells of C. glutamicum (3). Five genes (cg0273, cg0387, cg0400, cg2714, and cg3107) were annotated as potential ADH genes in the genome of C. glutamicum...”
- “...Pseudomonas aeruginosa. The other four proteins (Cg0273, Cg0387, Cg0400, and Cg2714) showed less similarity (40%) to all these ADHs. Therefore, cg3107 was...”
I1IPY8 Enoyl reductase (ER) domain-containing protein from Brachypodium distachyon
49% identity, 81% coverage
jhp1030 ZINC-DEPENDENT ALCOHOL DEHYDROGENASE from Helicobacter pylori J99
44% identity, 100% coverage
- Complexomics study of two Helicobacter pylori strains of two pathological origins: potential targets for vaccine development and new insight in bacteria metabolism
Bernarde, Molecular & cellular proteomics : MCP 2010 - “...JHP0023 JHP1290 JHP0068 JHP0181 JHP0216 JHP0573 JHP0791 JHP1030 JHP1004 JHP0180 JHP0161 JHP0161 JHP0551 JHP0992 JHP0216 JHP0560 JHP1091 JHP0763 JHP1471 JHP0101...”
- The orphan response regulator HP1021 of Helicobacter pylori regulates transcription of a gene cluster presumably involved in acetone metabolism
Pflock, Journal of bacteriology 2007 - “...HP1186 Central intermediary metabolism HP0089 HP0690 JHP0083 JHP1030 JHP1428 HP1104 HP1398 Fatty acid and phospholipid metabolism HP0090 JHP0636 JHP0637 HP0692...”
- Characterization of the ArsRS regulon of Helicobacter pylori, involved in acid adaptation
Pflock, Journal of bacteriology 2006 - “...JHP0823 0.47 HP0924 JHP0858 0.44 HP0954 HP1104 JHP0888 JHP1030 0.45 0.34 JHP0585* 0.27 JHP1429 0.29 HP0891 JHP0824 0.41 Gene and function d Genome organization...”
- Growth phase-dependent response of Helicobacter pylori to iron starvation
Merrell, Infection and immunity 2003 - “...3.6 2.2 2.5 2.8 2.4 JHP0991 JHP0516 JHP0569 JHP1030 Adhesin-thiol peroxidase, tagD GTP binding protein, gtp1 Protein E, gcpE Cinnamyl-alcohol dehydrogenase, cad...”
- “...ABC transporter, periplasmic iron-binding protein, ceuE2 JHP1030 cinnamyl-alcohol dehydrogenase EL13-2, cad a *, these genes show differential regulation...”
cad / O25732 cinnamyl-alcohol dehydrogenase (EC 1.1.1.2; EC 1.1.1.95; EC 1.1.1.195) from Helicobacter pylori (strain ATCC 700392 / 26695) (see 3 papers)
HP1104 cinnamyl-alcohol dehydrogenase ELI3-2 (cad) from Helicobacter pylori 26695
O25732 Cinnamyl-alcohol dehydrogenase ELI3-2 (Cad) from Helicobacter pylori (strain ATCC 700392 / 26695)
44% identity, 100% coverage
- A Case Control Study of the Seroprevalence of Helicobacter pylori Proteins and Their Association with Pancreatic Cancer Risk
Permuth, Journal of pancreatic cancer 2021 - “...HpA (HP410), Cag delta (HP522), CagM (HP537), CagA, HyuA, Catalase (HP875), VacA, HcpC (HP1098), Cad (HP1104), and HP1564. Materials and Methods Study population and biospecimens A prospectively maintained clinical database was retrospectively reviewed to identify individuals who were diagnosed and treated for PC (or premalignant pancreatic...”
- “...14 46.7 16 53.3 0.698 0.69 (0.301.59) HP1098 14 53.8 12 46.2 0.679 0.84 (0.352.03) HP1104 5 62.5 3 37.5 0.722 1.09 (0.235.19) HP1564 14 46.7 16 53.3 0.698 0.63 (0.271.51) CagA 14 48.3 15 51.7 0.844 0.91 (0.372.22) HyuA 11 37.9 18 62.1 0.168 0.49...”
- Performance of multiplex serology in discriminating active vs past Helicobacter pylori infection in a primarily African American population in the southeastern United States
Butt, Helicobacter 2020 - “...NP_207680 34363 26695 VacA C-Terminus 3281008 HP1098 HcpC Conserved hypothetical secreted protein NP_207889 1290 26695 HP1104 Cad Cinnamyl alcohol dehydrogenase ELI32 NP_207895 1348 26695 HP1564 HP1564 Hypothetical protein NP_208355 1271 26695 National Center for Biotechnology Information Reference Sequence Table 2: Characteristics of training set (DISH) and...”
- Anti-Helicobacter pylori Antibody Profiles in Epstein-Barr virus (EBV)-Positive and EBV-Negative Gastric Cancer
Camargo, Helicobacter 2016 - “...(n=111) Adjusted odds ratio * (95% confidence interval) Short name (gene symbol) Full name Cad (HP1104) Cinnamyl-alcohol dehydrogenase ELI3-2 22 23 0.68 (0.29-1.60) CagA (HP0547) Cytotoxin-associated gene A 95 87 2.63 (0.66-10.5) Cag (HP0522) CAG pathogenicity island protein 3 9 19 0.43 (0.14-1.31) CagM (HP0537) CAG...”
- Serological response to Helicobacter pylori infection among Latin American populations with contrasting risks of gastric cancer
Camargo, International journal of cancer 2015 - “...n=294/Low risk n=296 OR a (p-value) High risk n=295/Low risk n=292 OR a (p-value) Cad (HP1104) Cinnamyl-alcohol dehydrogenase ELI3-2 18/21 0.77 (0.2) 27/24 1.14 (0.5) 30/26 1.19 (0.3) CagA (HP0547) Cytotoxin-associated gene A 69/56 1.64 (0.004) 81/75 1.45 (0.068) 72/68 1.17 (0.4) Cag (HP0522) CAG pathogenicity...”
- Helicobacter pylori antibody patterns in Germany: a cross-sectional population study
Michel, Gut pathogens 2014 - “...Cag 107 35 13 60 < 0.0001 HP0695 HyuA 274 27 5 50 < 0.0001 HP1104 Cad 100 15 5 26 < 0.0001 HP0537 CagM 178 30 7 56 < 0.0001 HP0875 Catalase 487 31 9 56 < 0.0001 HP0231 HP0231 100 28 4 53 <...”
- Identification of a new class of adenosine deaminase from Helicobacter pylori with homologs among diverse taxa
Miller, Journal of bacteriology 2013 - “...0.28 15 8.3 2 HP1563 115 0.99 0.30 10 9.2 3 HP1104 68 0.19 0.68 6.1 20.5 85 0.04 1.88 7.7 56.6 4 5 HP0267 HP0974 Protein annotation Conserved hypothetical...”
- Targeted identification of glycosylated proteins in the gastric pathogen Helicobacter pylori (Hp)
Champasa, Molecular & cellular proteomics : MCP 2013 - “...acetyl-CoA synthetase cytoplasm 7 3 6.7 HP0169 P56113 prtC 49.9 collagenase unknown 2 2 6.7 HP1104 AAD08150 cad 40.6 cinnamyl-alcohol dehydrogenase cytoplasm 7 2 6.6 HP0470 AAD07532 pepF 70.9 oligoendopeptidase F cytoplasm 5 3 6.4 HP0422 AAD07486 speA 74.0 arginine decarboxylase periplasm 7 3 6.3 HP0510...”
- The orphan response regulator HP1021 of Helicobacter pylori regulates transcription of a gene cluster presumably involved in acetone metabolism
Pflock, Journal of bacteriology 2007 - “...intermediary metabolism HP0089 HP0690 JHP0083 JHP1030 JHP1428 HP1104 HP1398 Fatty acid and phospholipid metabolism HP0090 JHP0636 JHP0637 HP0692 Energy...”
- More
- Outer Membrane Vesicles Secreted by Helicobacter pylori Transmitting Gastric Pathogenic Virulence Factors
Wei, ACS omega 2022 - “...O25715 HP_1083 106 P56456 ileS 107 P56145 pheT 108 P56031 rplC 109 O24914 HP_0087 110 O25732 Cad 111 O25116 pyrG 112 O25383 HP_0672 113 O25787 HP_1173 114 O25166 HP_0410 115 O25052 AddB 116 O25465 HP_0773 117 O25008 iscS 118 O25067 amiE 119 P56060 kdsA 120 O25658...”
- “...O25294 pepA 33 O26083 HP_1562 34 O25423 HP_0721 35 P14916 ureA 36 O06913 frdA 37 O25732 HP_1104 38 O25284 HP_0558 39 O25052 AddB 40 P56008 rpsA 41 O25015 Omp6 42 O25786 GlnH 43 O24925 TlpA 44 P56112 HP_0175 45 O25749 HP_1124 46 O26084 HP_1564 47 P56456...”
XP_027363622 probable cinnamyl alcohol dehydrogenase from Abrus precatorius
46% identity, 95% coverage
- Anther dehiscence is regulated by gibberellic acid in yellow lupine (Lupinus luteus L.)
Marciniak, BMC plant biology 2021 - “...]. Lang - Lupinus angustifolius (XP_019452456); Lalb - Lupinus albus (KAE9589372); Ap - Abrus precatorius (XP_027363622); Vu - Vigna unguiculata (XP_027937462); Gs - Glycine soja (XP_028185029); Gm - Glycine max (XP_003555961); Ss - Spatholobus suberectus (TKY50969); Ck - Caragana korshinskii (AEV93476); Ah - Arachis hypogaea (XP_025620500);...”
- “...identical. Lang - Lupinus angustifolius (XP_019452456); Lalb - Lupinus albus (KAE9589372); Ap - Abrus precatorius (XP_027363622); Vu - Vigna unguiculata (XP_027937462); Gs - Glycine soja (XP_028185029); Gm - Glycine max (XP_003555961); Ss - Spatholobus suberectus (TKY50969); Ck - Caragana korshinskii (AEV93476); Ah - Arachis hypogaea (XP_025620500);...”
Cj1548c putative NADP-dependent alcohol dehydrogenase from Campylobacter jejuni subsp. jejuni NCTC 11168
CJJ81176_1533 oxidoreductase, zinc-binding dehydrogenase family from Campylobacter jejuni subsp. jejuni 81-176
46% identity, 95% coverage
Q8H0L8 alcohol dehydrogenase [NAD(P)+] (EC 1.1.1.71) from Solanum tuberosum (see paper)
50% identity, 95% coverage
LOC21409656 cinnamyl alcohol dehydrogenase 1 from Morus notabilis
LOC21409658 cinnamyl alcohol dehydrogenase 1 from Morus notabilis
45% identity, 96% coverage
LOC103335288 probable mannitol dehydrogenase from Prunus mume
48% identity, 96% coverage
XP_028185029 probable cinnamyl alcohol dehydrogenase from Glycine soja
47% identity, 95% coverage
LOC102600145 8-hydroxygeraniol dehydrogenase-like from Solanum tuberosum
50% identity, 95% coverage
- Potato tuber degradation is regulated by carbohydrate metabolism: Results of transcriptomic analysis
Jia, Plant direct 2022 - “...ID Log2Fold Pvalue Padj Gene name Gene description Change Upregulated genes 102600145 13.97 1.02E07 2.16E04 LOC102600145 8hydroxygeraniol dehydrogenaselike 102601831 13.39 8.71E07 6.84E04 LOC102601831 Polygalacturonaselike 102580870 11.09 6.85E07 6.69E04 LOC102580870 Miraculin 107063347 11.08 3.27E05 4.69E03 LOC107063347 Putative uncharacterised protein DDB_G0277255 102593741 10.39 2.31E05 3.82E03 LOC102593741 Coiledcoil domaincontaining...”
6k3gB / Q6V4H0 Crystal structure of 10-hydroxygeraniol dehydrogenase from cantharanthus roseus in complex with NADP+ (see paper)
50% identity, 97% coverage
- Ligands: nadp nicotinamide-adenine-dinucleotide phosphate; zinc ion (6k3gB)
XP_020210039 probable cinnamyl alcohol dehydrogenase from Cajanus cajan
47% identity, 95% coverage
- Anther dehiscence is regulated by gibberellic acid in yellow lupine (Lupinus luteus L.)
Marciniak, BMC plant biology 2021 - “...(XP_016175492); In - Ipomoea nil (XP_019169368); Mt - Medicago truncatula (XP_013470061); Cc - Cajanus cajan (XP_020210039); At - Arabidopsis thaliana (AAK44076). Fig. S1 d. Comparison of CAD proteins derived from different plant species (BlastP) using the DiAlign program (Genomatix). For each pairwise alignment, the similarity (relative...”
- “...(XP_016175492); In - Ipomoea nil (XP_019169368); Mt - Medicago truncatula (XP_013470061); Cc - Cajanus cajan (XP_020210039); At - Arabidopsis thaliana (AAK44076). Fig. S2 a. LlCesA8 (alternative name LlIRX1) cDNA (GenBank accession number MW240677, 3788bp) identified in yellow lupine ( Lupinus luteus L.) and its deduced amino...”
10HGO / Q6V4H0 8-hydroxygeraniol dehydrogenase (EC 1.1.1.324) from Catharanthus roseus (see paper)
10HGO_CATRO / Q6V4H0 8-hydroxygeraniol dehydrogenase; Cr10HGO; EC 1.1.1.324 from Catharanthus roseus (Madagascar periwinkle) (Vinca rosea)
50% identity, 96% coverage
- function: Dehydrogenase involved in the biosynthesis of oxogeranial from hydroxygeraniol, a precursor of the terpenoid indole alkaloids such as vinblastine and vincristine.
catalytic activity: (6E)-8-hydroxygeraniol + 2 NADP(+) = (6E)-8-oxogeranial + 2 NADPH + 2 H(+) (RHEA:32659)
cofactor: Zn(2+)
XP_010943210 cinnamyl alcohol dehydrogenase 2 from Elaeis guineensis
46% identity, 96% coverage
- Genome-wide identification of the CAD gene family and functional analysis of putative bona fide CAD genes in tobacco (Nicotiana tabacum L.)
Wu, Frontiers in plant science 2024 - “...BdCAD3 (AFK80371), BdCAD5 (AFK80372); Triticum aestivum , TaCAD1 (GU563724); Elaeis guineensis , EgCAD1 (UTE99576), EgCAD (XP_010943210); Medicago sativa , MsCAD1 (O82515), MsCAD2 (P31656); Morus alba , MaCAD15 (UZH97791, UZH97792, UZH97793, UZH97794, UZH97795); Picea abies , PaCAD1 (CAA05097); Populus tremuloides , PtCAD (AAF43140); Pinus taeda , PtaCAD...”
- Genome-wide analysis of the CAD gene family reveals two bona fide CAD genes in oil palm
Yusuf, 3 Biotech 2022 - “...AtCAD5: At4g34230 (Phytozome), EgCAD1: XP_010932224 and EgCAD2: XP_010943210. The 3D structures of bona fide EgCADs were constructed based on the crystal...”
Q8H859 Probable cinnamyl alcohol dehydrogenase 1 from Oryza sativa subsp. japonica
47% identity, 97% coverage
- Genome-wide identification of the CAD gene family and functional analysis of putative bona fide CAD genes in tobacco (Nicotiana tabacum L.)
Wu, Frontiers in plant science 2024 - “...(accession number: Q9CAI3, Q9SJ25, Q9SJ10, P48523, O49482, O65621, Q02971, Q02972, P42734); Oryza sativa , OsCAD19 (Q8H859, Q6ZHS4, Q337Y2, Q2R114, Q0J6T3, Q7XWU3, Q0JA75, Q6ERX1, Q10PS6); Brachypodium distachyon , BdCAD3 (AFK80371), BdCAD5 (AFK80372); Triticum aestivum , TaCAD1 (GU563724); Elaeis guineensis , EgCAD1 (UTE99576), EgCAD (XP_010943210); Medicago sativa ,...”
- iTRAQ based proteomic analysis of rice lines having single or stacked blast resistance genes: Pi54/Pi54rh during incompatible interaction with Magnaporthe oryzae
Kumari, Physiology and molecular biology of plants : an international journal of functional plant biology 2023 - “...this category of proteins, 3 loci of dehydrogenases (Q8H859, Q337Y2and Q7Y096), 2 loci of beta-glucosidase (A0A0P0WBJ3, Q10CU9) and single locus each of...”
- “...each of caffeoyl-CoA O-methyltransferase (Q9XJ19), dehydrogenases (Q8H859) and peroxidase (Q5U1F5), two loci of beta-glucosidase were upregulated 13...”
- Polymyxin B1 and E2 From Paenibacillus polymyxa Y-1 for Controlling Rice Bacterial Disease
Yi, Frontiers in cellular and infection microbiology 2022 - “...Q7XSU8) and 2 downregulated ones (A0A0P0V2C2, Q9AS12) involved in the regulation of POD. Meanwhile, CAD (Q8H859, Q6ERW9, and Q6ERW7) and GLU (Q60DX8) proteins were upregulated, but CYP73A (A2Y375) was downregulated ( Figure8 ). It is well-known that POD and CAD are able to regulate the formation...”
- “...PB/CK ratio of Q94DM2 and Q6ZCC2 protein was 9.89 and 8.34, respectively. Expression levels of Q8H859 and Q6ERW9 of CAD upregulated 2.34-fold and 2.19-fold versus CK groups. Among DEPs of phenylpropanoid biosynthesis pathway, A0A0P0V2C2, Q9AS12, and A2Y375 were downregulated. The PRM results demonstrated that polymyxin B...”
- Molecular responses of Lotus japonicus to parasitism by the compatible species Orobanche aegyptiaca and the incompatible species Striga hermonthica
Hiraoka, Journal of experimental botany 2009 - “...Arabidopsis thaliana ; NP_565380) 3.0E-06 BB999881 LjOa143 Putative cinnamyl alcohol dehydrogenase ( Oryza sativa ; Q8H859) 1.5E-41 BB999904 LjOa40-2 Peroxidase precursor ( Vigna angularis ; Q43854) 1.0E-67 BB999928 Detoxification of reactive oxygen species LjOa141-1 NADH dehydrogenase ND6 ( Lotus japonicus ; BAB33248) 0.77 BB999922 Other function...”
- “...Lotus corniculatus ; AY028929) 1.1E-147 BB999949 LjSh269-1 Putative cinnamyl alcohol dehydrogenase ( Oryza sativa ; Q8H859) 1.3E-29 BB999958 Detoxification of reactive oxygen species LjSh7 Phospholipid hydroperoxide glutathione peroxidase ( Momordica charantia ; Q8W259) 7.3E-42 BB999947 LjSh182-1 Homogentisic acid geranylgeranyl transferase ( Triticum aestivum ; Q7XB13) 3.0E-66...”
CADH7_ORYSJ / Q0JA75 Cinnamyl alcohol dehydrogenase 7; OsCAD7; Protein FLEXIBLE CULM 1; EC 1.1.1.195 from Oryza sativa subsp. japonica (Rice) (see paper)
48% identity, 93% coverage
- function: Involved in lignin biosynthesis. May catalyze the final step specific for the production of lignin monomers, like coniferyl alcohol, sinapyl alcohol and 4-coumaryl alcohol.
catalytic activity: (E)-cinnamyl alcohol + NADP(+) = (E)-cinnamaldehyde + NADPH + H(+) (RHEA:10392)
catalytic activity: (E)-coniferol + NADP(+) = (E)-coniferaldehyde + NADPH + H(+) (RHEA:22444)
catalytic activity: (E)-sinapyl alcohol + NADP(+) = (E)-sinapaldehyde + NADPH + H(+) (RHEA:45704)
catalytic activity: (E)-4-coumaroyl alcohol + NADP(+) = (E)-4-coumaraldehyde + NADPH + H(+) (RHEA:45724)
catalytic activity: (E)-caffeyl alcohol + NADP(+) = (E)-caffeyl aldehyde + NADPH + H(+) (RHEA:45728)
cofactor: Zn(2+) (Binds 2 Zn(2+) ions per subunit.)
subunit: Homodimer.
disruption phenotype: Reduced lignin content, late heading time, semi- dwarf and flexible culm. - Genome-wide identification of the CAD gene family and functional analysis of putative bona fide CAD genes in tobacco (Nicotiana tabacum L.)
Wu, Frontiers in plant science 2024 - “...O49482, O65621, Q02971, Q02972, P42734); Oryza sativa , OsCAD19 (Q8H859, Q6ZHS4, Q337Y2, Q2R114, Q0J6T3, Q7XWU3, Q0JA75, Q6ERX1, Q10PS6); Brachypodium distachyon , BdCAD3 (AFK80371), BdCAD5 (AFK80372); Triticum aestivum , TaCAD1 (GU563724); Elaeis guineensis , EgCAD1 (UTE99576), EgCAD (XP_010943210); Medicago sativa , MsCAD1 (O82515), MsCAD2 (P31656); Morus alba...”
- Pluronic F-68 Improves Callus Proliferation of Recalcitrant Rice Cultivar via Enhanced Carbon and Nitrogen Metabolism and Nutrients Uptake.
Kok, Frontiers in plant science 2021 - “...0.98280 16 Histone H3.2 Q2RAD9 Signaling and Cellular Process 0.96914 17 Cinnamyl alcohol dehydrogenase 7 Q0JA75 Phenylpropanoid Biosynthesis 0.92934 18 Actin-7 P0C540 Signaling and Cellular Process 0.91432 19 Thioredoxin-like protein CXXS1 Q0J9V5 Translational Modification 0.86712 20 Delta-aminolevulinic acid dehydratase, chloroplastic Q5Z8V9 Secondary Metabolites Biosynthesis 0.84856 Down-regulated...”
B5TR18 cinnamyl-alcohol dehydrogenase (EC 1.1.1.195) from Leucaena leucocephala (see paper)
45% identity, 95% coverage
XP_003555961 probable cinnamyl alcohol dehydrogenase from Glycine max
47% identity, 95% coverage
D0ITF8 cinnamyl-alcohol dehydrogenase (EC 1.1.1.195) from Helicobacter pylori (see paper)
3twoB The crystal structure of cad from helicobacter pylori complexed with NADP(h) (see paper)
43% identity, 100% coverage
- Ligands: nadph dihydro-nicotinamide-adenine-dinucleotide phosphate; zinc ion (3twoB)
GRMZM2G167613 putative cinnamyl-alcohol dehydrogenase family protein from Zea mays
48% identity, 96% coverage
- A leucine-rich repeat-receptor-like kinase gene SbER2-1 from sorghum (Sorghum bicolor L.) confers drought tolerance in maize
Li, BMC genomics 2019 - “...lines compared with NT lines under severe drought stress. In stems, the expression levels of GRMZM2G167613 and GRMZM2G170692 , which functions as key enzyme of lignin synthetic pathway, cinnamyl alcohol dehydrogenase (CAD) and phenylalanine ammonia lyase (PAL) respectively, increased in the SbER21 transgenic maize lines compared...”
- “...antioxidant potential, composition, and sensory features [ 32 ]. Further analysis from phenylpropanoid biosynthesis revealed GRMZM2G167613 and GRMZM2G170692 were two key enzyme genes of lignin synthetic pathway, CAD and PAL that positively correlated with lignin content. Lignin can provide cell wall rigidity and enhance the ability...”
- A secreted Ustilago maydis effector promotes virulence by targeting anthocyanin biosynthesis in maize
Tanaka, eLife 2014 - “...ZmBx2, GRMZM2G085661; ZmBx5, GRMZM2G063756; ZmBx8, GRMZM2G085054; Zm4CL, GRMZM2G075333, GRMZM2G054013; ZmCCR, GRMZM2G131205, GRMZM2G131836; ZmCAD, GRMZM2G046070, GRMZM5G844562, GRMZM2G167613, AC234163.1_FGP002, GRMZM2G700188, GRMZM2G118610. Funding Information This paper was supported by the following grants: Max Planck Society to Shigeyuki Tanaka, Thomas Brefort, Nina Neidig, Armin Djamei, Jrg Kahnt, Regine Kahmann. DFG...”
XP_019452456 probable cinnamyl alcohol dehydrogenase from Lupinus angustifolius
47% identity, 95% coverage
- Anther dehiscence is regulated by gibberellic acid in yellow lupine (Lupinus luteus L.)
Marciniak, BMC plant biology 2021 - “...identified according to the results described by [ 38 40 ]. Lang - Lupinus angustifolius (XP_019452456); Lalb - Lupinus albus (KAE9589372); Ap - Abrus precatorius (XP_027363622); Vu - Vigna unguiculata (XP_027937462); Gs - Glycine soja (XP_028185029); Gm - Glycine max (XP_003555961); Ss - Spatholobus suberectus (TKY50969);...”
- “...sequences; it does not necessarily mean that these sequences are identical. Lang - Lupinus angustifolius (XP_019452456); Lalb - Lupinus albus (KAE9589372); Ap - Abrus precatorius (XP_027363622); Vu - Vigna unguiculata (XP_027937462); Gs - Glycine soja (XP_028185029); Gm - Glycine max (XP_003555961); Ss - Spatholobus suberectus (TKY50969);...”
XP_027937462 probable cinnamyl alcohol dehydrogenase from Vigna unguiculata
46% identity, 95% coverage
XP_003593290 probable cinnamyl alcohol dehydrogenase 1 isoform X2 from Medicago truncatula
48% identity, 97% coverage
CADH1_ARATH / Q9CAI3 Probable cinnamyl alcohol dehydrogenase 1; AtCAD1; EC 1.1.1.195 from Arabidopsis thaliana (Mouse-ear cress) (see 2 papers)
AT1G72680 cinnamyl-alcohol dehydrogenase, putative from Arabidopsis thaliana
NP_177412 cinnamyl-alcohol dehydrogenase from Arabidopsis thaliana
48% identity, 97% coverage
- function: Involved in lignin biosynthesis. Catalyzes the final step specific for the production of lignin monomers. Catalyzes the NADPH- dependent reduction of coniferaldehyde, 5-hydroxyconiferaldehyde, sinapaldehyde, 4-coumaraldehyde and caffeyl aldehyde to their respective alcohols.
catalytic activity: (E)-cinnamyl alcohol + NADP(+) = (E)-cinnamaldehyde + NADPH + H(+) (RHEA:10392)
catalytic activity: (E)-coniferol + NADP(+) = (E)-coniferaldehyde + NADPH + H(+) (RHEA:22444)
catalytic activity: (E)-sinapyl alcohol + NADP(+) = (E)-sinapaldehyde + NADPH + H(+) (RHEA:45704)
catalytic activity: (E)-4-coumaroyl alcohol + NADP(+) = (E)-4-coumaraldehyde + NADPH + H(+) (RHEA:45724)
catalytic activity: (E)-caffeyl alcohol + NADP(+) = (E)-caffeyl aldehyde + NADPH + H(+) (RHEA:45728)
cofactor: Zn(2+) (Binds 2 Zn(2+) ions per subunit.)
subunit: Homodimer. - What Antarctic Plants Can Tell Us about Climate Changes: Temperature as a Driver for Metabolic Reprogramming
Bertini, Biomolecules 2021 - “...mentioning that in this work we also found the downregulation of the cynnamil-alcohol dehydrogenase CAD1 (AT1G72680, log 2 FC = 2.64), involved in lignin biosynthesis, strengthening the evidence that warming reduces the deposition of cell wall components. 4. Conclusions In conclusion, our analysis revealed that OTCs...”
- “...S7e family protein 5.25 10 3 2.81 AT1G53450 Epstein-barr nuclear antigen 2.81 10 3 2.74 AT1G72680 ATCAD1, CAD1, cinnamyl-alcohol dehydrogenase 3.17 10 3 2.64 AT5G26780 SHM2, serine hydroxymethyltransferase 2 9.12 10 4 2.62 AT4G11600 ATGPX6, GPX6, LSC803, PHGPX, glutathione peroxidase 6 3.98 10 3 2.58 AT2G45300...”
- CAD Genes: Genome-Wide Identification, Evolution, and Their Contribution to Lignin Biosynthesis in Pear (Pyrus bretschneideri)
Qi, Plants (Basel, Switzerland) 2021 - “...Database for Rosaceae ( http://www.rosaceae.org/ , 25 September 2019). Nine CAD protein sequences of Arabidopsis (AT1G72680, AT2G21730, AT2G21890, AT3G19450, AT4G34230, AT4G37970, AT4G37980, AT4G37990, and AT4G39330) were downloaded from The Arabidopsis Information Resource ( http://www.arabidopsis.org/ , 25 September 2019) and used as queries to perform a BLAST...”
- Transcriptomic Changes in Internode Explants of Stinging Nettle during Callogenesis
Xu, International journal of molecular sciences 2021 - “...found in C2 ( Dataset S1 ); orthologs of thale cress CAD1 and CAD3 ( At1g72680 and At2g21890 , corresponding to contig_1059 and contig_4205, respectively, with log2FC 10D vs. 0D > 3.5), as well as PAL1 ( At2g37040 , contig_4482), which almost doubled in expression at...”
- Shotgun proteomics of peach fruit reveals major metabolic pathways associated to ripening
Nilo-Poyanco, BMC genomics 2021 - “...Prupe.2G263900 1 4 Qualit_O1 CHALCONE--FLAVONONE ISOMERASE 3-RELATED AT5G05270 Prupe.3G194000 1 2 Qualit_O1 Cinnamyl alcohol dehydrogenase AT1G72680 Photoperiodic Flowering Regulation Prupe.6G149500 0.614 1 Qualit_O1 Ubiquitin carboxyl-terminal hydrolase 12 AT5G06600 Polyamines metabolism Prupe.5G078900 0.977 1 Qualit_O1 AMINE OXIDASE-RELATED AT4G12290 Prupe.1G255300 0.5 1 Up_O1 spermidine synthase (speE, SRM) AT1G23820...”
- Using Gene Expression to Study Specialized Metabolism-A Practical Guide
Delli-Ponti, Frontiers in plant science 2020 - “...members of the CAD family. We entered the 14 ( AT2G37040, AT3G10340, AT3G53260, AT5G04230, AT2G30490, AT1G72680, AT2G21730, AT2G21890, AT3G19450, AT4G34230, AT4G37970, AT4G37980, AT4G37990 , and AT4G39330 ) genes into the Tools/Heatmap/Comparative 2 , which revealed the expression profiles of these genes in organs of Arabidopsis ....”
- Stimulation of adventitious root formation by the oligosaccharin OSRG at the transcriptome level
Larskaya, Plant signaling & behavior 2020 (secret) - Global Transcriptomic Profile Analysis of Genes Involved in Lignin Biosynthesis and Accumulation Induced by Boron Deficiency in Poplar Roots
Su, Biomolecules 2019 - “...reductase 1.40 AT2G33590 CAD Potri.001G256400 PtrCAD cinnamoyl-CoA reductase 1.24 AT5G19440 Potri.006G024300 PtrCAD16 cinnamyl-alcohol dehydrogenase 3.33 AT1G72680 Potri.009G095800 PtrCAD1 cinnamyl-alcohol dehydrogenase 1.25 AT4G34230 Potri.009G063100 PtrCAD3 cinnamyl-alcohol dehydrogenase 1.95 AT4G37990 Potri.009G062800 PtrCAD5 cinnamyl-alcohol dehydrogenase 2.70 AT4G37990 Potri.001G268600 PtrCAD7 1.38 AT4G37990 Potri.001G300000 cinnamyl-alcohol dehydrogenase 2.71 AT4G34230 F5H Potri.005G117500 PtrCAld5H1...”
- Nitrogen Source Dependent Changes in Central Sugar Metabolism Maintain Cell Wall Assembly in Mitochondrial Complex I-Defective frostbite1 and Secondarily Affect Programmed Cell Death
Podgórska, International journal of molecular sciences 2018 - “...5 B). Primary genes involved in lignin biosynthesis are cinnamyl alcohol dehydrogenase genes (CAD) CAD1 (AT1G72680), CAD4 (AT3G19450), and CAD5 (AT4G34230) [ 61 ]. The fro1 mutant did not show significant changes in the expression of any of the analyzed CAD genes as compared to WT...”
- “...CesA3 (AT5G05170), CesA4 (AT5G44030), CesA6 (AT5G64740), CesA7 (AT5G17420), CesA8 (AT4G18780), SnRK1.1 (AT3G01090), HXK1 (AT4G29130), CAD1 (AT1G72680), CAD4 (AT3G19450), CAD5 (AT4G34230), POX33 (AT3G49110), POX34 (AT3G49120), POX64 (AT5G42180), POX72 (AT5G66390), BI-1 (AT5G47120), and ATG5 (AT5G17290) ( Supplementary Materials Table S1 ), in which one sequence spanned always an...”
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- Physcomitrium patens CAD1 has distinct roles in growth and resistance to biotic stress
Jiang, BMC plant biology 2022 - “...(NP_195643); AtCAD2 (NP_195510); AtCAD3(CAA48027); AtCAD4 (NP_195512); AtCAD5 (NP_188576); AtCAD6 (NP_195149); AtCAD7 (NP_179765); AtCAD8 (NP_179780); AtCAD9 (NP_177412); Populus tremuloides PtCAD1 (AAF43140); PtCAD2 (AAK58693);PtCAD3 (AAK58693); PtCAD4 (AAK58693); PtCAD5 (AAK58693); PtCAD6 (AAK58693); PtCAD7 (AAK58693); PtCAD8 (AAK58693) PtCAD9 (AAK58693); Oryza sativa OsCAD1 (DAA02237); OsCAD2 (DAA02237); OsCAD3 (DAA02237); OsCAD4 (DAA02237); OsCAD5...”
- Genome-wide identification of the CAD gene family and functional analysis of putative bona fide CAD genes in tobacco (Nicotiana tabacum L.)
Wu, Frontiers in plant science 2024 - “...in this study include tobacco (Ntab, Ntom, and Nsyl); Arabidopsis thaliana , AtCAD19 (accession number: Q9CAI3, Q9SJ25, Q9SJ10, P48523, O49482, O65621, Q02971, Q02972, P42734); Oryza sativa , OsCAD19 (Q8H859, Q6ZHS4, Q337Y2, Q2R114, Q0J6T3, Q7XWU3, Q0JA75, Q6ERX1, Q10PS6); Brachypodium distachyon , BdCAD3 (AFK80371), BdCAD5 (AFK80372); Triticum aestivum...”
LOC18040966 probable cinnamyl alcohol dehydrogenase 6 from Citrus x clementina
45% identity, 96% coverage
MTD / Q38707 mannitol dehydrogenase (EC 1.1.1.255) from Apium graveolens (see paper)
Q38707 mannitol dehydrogenase (EC 1.1.1.255) from Apium graveolens (see paper)
45% identity, 95% coverage
5vktA / C5XC49 Cinnamyl alcohol dehydrogenases (sbcad4) from sorghum bicolor (l.) Moench (see paper)
48% identity, 97% coverage
- Ligands: zinc ion; nadp nicotinamide-adenine-dinucleotide phosphate (5vktA)
C5XC49 cinnamyl-alcohol dehydrogenase (EC 1.1.1.195) from Sorghum bicolor (see 2 papers)
XP_002462348 probable cinnamyl alcohol dehydrogenase 8D from Sorghum bicolor
48% identity, 94% coverage
Q7XWU3 cinnamyl-alcohol dehydrogenase (EC 1.1.1.195) from Oryza sativa Japonica Group (see paper)
47% identity, 97% coverage
- Genome-wide identification of the CAD gene family and functional analysis of putative bona fide CAD genes in tobacco (Nicotiana tabacum L.)
Wu, Frontiers in plant science 2024 - “...P48523, O49482, O65621, Q02971, Q02972, P42734); Oryza sativa , OsCAD19 (Q8H859, Q6ZHS4, Q337Y2, Q2R114, Q0J6T3, Q7XWU3, Q0JA75, Q6ERX1, Q10PS6); Brachypodium distachyon , BdCAD3 (AFK80371), BdCAD5 (AFK80372); Triticum aestivum , TaCAD1 (GU563724); Elaeis guineensis , EgCAD1 (UTE99576), EgCAD (XP_010943210); Medicago sativa , MsCAD1 (O82515), MsCAD2 (P31656); Morus...”
P31656 Probable cinnamyl alcohol dehydrogenase from Medicago sativa
47% identity, 95% coverage
- Genome-wide identification of the CAD gene family and functional analysis of putative bona fide CAD genes in tobacco (Nicotiana tabacum L.)
Wu, Frontiers in plant science 2024 - “...TaCAD1 (GU563724); Elaeis guineensis , EgCAD1 (UTE99576), EgCAD (XP_010943210); Medicago sativa , MsCAD1 (O82515), MsCAD2 (P31656); Morus alba , MaCAD15 (UZH97791, UZH97792, UZH97793, UZH97794, UZH97795); Picea abies , PaCAD1 (CAA05097); Populus tremuloides , PtCAD (AAF43140); Pinus taeda , PtaCAD (CAA86073); Populus tomentosa , PtoCAD1, 2, 3,...”
LOC101245999 probable cinnamyl alcohol dehydrogenase 6 from Solanum lycopersicum
45% identity, 96% coverage
Q0J6T3 Probable cinnamyl alcohol dehydrogenase 5 from Oryza sativa subsp. japonica
48% identity, 95% coverage
- Genome-wide identification of the CAD gene family and functional analysis of putative bona fide CAD genes in tobacco (Nicotiana tabacum L.)
Wu, Frontiers in plant science 2024 - “...Q9SJ10, P48523, O49482, O65621, Q02971, Q02972, P42734); Oryza sativa , OsCAD19 (Q8H859, Q6ZHS4, Q337Y2, Q2R114, Q0J6T3, Q7XWU3, Q0JA75, Q6ERX1, Q10PS6); Brachypodium distachyon , BdCAD3 (AFK80371), BdCAD5 (AFK80372); Triticum aestivum , TaCAD1 (GU563724); Elaeis guineensis , EgCAD1 (UTE99576), EgCAD (XP_010943210); Medicago sativa , MsCAD1 (O82515), MsCAD2 (P31656);...”
LOC122078387 probable cinnamyl alcohol dehydrogenase from Macadamia integrifolia
45% identity, 96% coverage
- Comparative Transcriptome Analysis Reveals Key Functions of MiMYB Gene Family in Macadamia Nut Pericarp Formation
Tan, International journal of molecular sciences 2024 - “...most of which were highly expressed in Guire No.1, the FPKM of LOC122092787, LOC122089414, LOC122069164, LOC122078387, LOC122067873, LOC122088272, LOC122073309, and LOC122063458 was 291.94, 245.63, 239.09, 204.56, 181.53, 172.22, 170.63, and 140.55, significantly higher than that in A38 and HAES900 ( Supplementary Table S8 ). Most of...”
CAD1_MEDTR / A0A072VPZ8 Cinnamyl alcohol dehydrogenase 1; Mt-CAD1; Coniferol dehydrogenase; Coumaroyl alcohol dehydrogenase; Sinapyl alcohol dehydrogenase; EC 1.1.1.195 from Medicago truncatula (Barrel medic) (Medicago tribuloides) (see paper)
XP_013470061 probable cinnamyl alcohol dehydrogenase from Medicago truncatula
46% identity, 95% coverage
- function: Involved in lignin biosynthesis. Catalyzes the final step specific for the production of lignin monomers. Catalyzes the NADPH- dependent reduction of coniferaldehyde, 5-hydroxyconiferaldehyde, sinapaldehyde, 4-coumaraldehyde and caffeyl aldehyde to their respective alcohols (By similarity). Can use coumaraldehyde and, with a lower efficiency, coniferaldehyde and sinapaldehyde as substrates (PubMed:25217505).
catalytic activity: (E)-cinnamyl alcohol + NADP(+) = (E)-cinnamaldehyde + NADPH + H(+) (RHEA:10392)
catalytic activity: (E)-coniferol + NADP(+) = (E)-coniferaldehyde + NADPH + H(+) (RHEA:22444)
catalytic activity: (E)-sinapyl alcohol + NADP(+) = (E)-sinapaldehyde + NADPH + H(+) (RHEA:45704)
catalytic activity: (E)-4-coumaroyl alcohol + NADP(+) = (E)-4-coumaraldehyde + NADPH + H(+) (RHEA:45724)
cofactor: Zn(2+) (Binds 2 Zn(2+) ions per subunit.)
subunit: Homodimer. - Anther dehiscence is regulated by gibberellic acid in yellow lupine (Lupinus luteus L.)
Marciniak, BMC plant biology 2021 - “...(XP_015941997); Ai - Arachis ipaensis (XP_016175492); In - Ipomoea nil (XP_019169368); Mt - Medicago truncatula (XP_013470061); Cc - Cajanus cajan (XP_020210039); At - Arabidopsis thaliana (AAK44076). Fig. S1 d. Comparison of CAD proteins derived from different plant species (BlastP) using the DiAlign program (Genomatix). For each...”
- “...(XP_015941997); Ai - Arachis ipaensis (XP_016175492); In - Ipomoea nil (XP_019169368); Mt - Medicago truncatula (XP_013470061); Cc - Cajanus cajan (XP_020210039); At - Arabidopsis thaliana (AAK44076). Fig. S2 a. LlCesA8 (alternative name LlIRX1) cDNA (GenBank accession number MW240677, 3788bp) identified in yellow lupine ( Lupinus luteus...”
LOC107426959 probable cinnamyl alcohol dehydrogenase from Ziziphus jujuba
45% identity, 97% coverage
- The regulation of cell wall lignification and lignin biosynthesis during pigmentation of winter jujube
Zhang, Horticulture research 2021 - “...F5H and CCR play key roles in G-S lignin biosynthesis. The expression of CAD ( LOC107426959 ) was consistent with the accumulation of p-coumeric alcohol and may be the key gene for H-lignin biosynthesis. Expression analysis of MYB TFs related to lignin biosynthesis A phylogenetic tree...”
- “...the pericarp of winter jujube. Notably, we also found that the expression of CAD ( LOC107426959 ) was consistent with the accumulation of p-coumaric alcohol (Fig. 3 ), which was in line with a previous report that CAD was one of the specific enzymes in the...”
M7Y7E2 cinnamyl-alcohol dehydrogenase from Triticum urartu
48% identity, 90% coverage
CADH8_ARATH / Q02972 Cinnamyl alcohol dehydrogenase 8; AtCAD8; NAD-dependent mannitol dehydrogenase 2; EC 1.1.1.195 from Arabidopsis thaliana (Mouse-ear cress) (see 3 papers)
AT4G37990 ELI3-2 (ELICITOR-ACTIVATED GENE 3-2); aryl-alcohol dehydrogenase/ mannitol dehydrogenase from Arabidopsis thaliana
NP_195512 cinnamyl alcohol dehydrogenase 8 from Arabidopsis thaliana
49% identity, 96% coverage
- function: Involved in lignin biosynthesis. Catalyzes the final step specific for the production of lignin monomers. Catalyzes the NADPH- dependent reduction of coniferaldehyde, 5-hydroxyconiferaldehyde, sinapaldehyde, 4-coumaraldehyde and caffeyl aldehyde to their respective alcohols.
catalytic activity: (E)-cinnamyl alcohol + NADP(+) = (E)-cinnamaldehyde + NADPH + H(+) (RHEA:10392)
cofactor: Zn(2+) (Binds 2 Zn(2+) ions per subunit.)
subunit: Homodimer. - Arabidopsis Transcriptomics Reveals the Role of Lipoxygenase2 (AtLOX2) in Wound-Induced Responses
Kaur, International journal of molecular sciences 2024 - “...), GSTF12 ( At5g17220 ), 5MAT ( At3g29590 ), MYB15 ( At3g23250 ), CAD8 ( At4g37990 ), PRX52 ( At5g05340 ), SST/SCPL9 ( At2g23010 ). Figure 7 Foliar glucosinolate (GSL) levels and expression of GSL biosynthesis genes. Four-week-old Arabidopsis thaliana wildtype (WT) or lox2 plants were...”
- The Change in Whole-Genome Methylation and Transcriptome Profile under Autophagy Defect and Nitrogen Starvation
Shi, International journal of molecular sciences 2023 - “...(AT1G47600) genes were enriched in multiple metabolism-related GO terms, and in biosynthesis-related GO terms, ATCAD8 (AT4G37990), LAC11 (AT5G03260), and ATMYB29 (AT5G07690) were also enriched. In addition, the DNA methylation processes were probably regulated. For example, DNA methylation on cytosine within a CG sequence, maintenance of DNA...”
- Cell specialization and coordination in Arabidopsis leaves upon pathogenic attack revealed by scRNA-seq
Delannoy, Plant communications 2023 - “...known to be induced upon pathogenic bacterial challenge such as AT3G22600 , AT4G22470 , or AT4G37990 ( Supplemental Table3 ). The C13 population is characterized mainly by phytoalexin synthesis, detoxification, and SA-mediated defense responses, especially SAR ( Figure2 A; Supplemental Table3 ). For instance, PAD3 and...”
- Different combinations of laccase paralogs nonredundantly control the amount and composition of lignin in specific cell types and cell wall layers in Arabidopsis
Blaschek, The Plant cell 2023 - “...genes discussed in this article are as follows: F5H1 (At4g36220), CCR1 (At1g15950); CAD4 (At4g37980); CAD5 (At4g37990); XCP1 (At4g35350); XCP2 (At1g20850) CesA7/IRX3 (At5g17420); LAC1 (At1g18140); LAC2 (At2g29130); LAC3 (At2g30210); LAC4/IRX12 (At2g38080); LAC5 (At2g40370); LAC6 (At2g46570); LAC7 (At3g09220); LAC8 (At5g01040); LAC9 (At5g01050); LAC10 (At5g01190); LAC11 (At5g03260); LAC12 (At5g05390);...”
- Global transcriptome analysis reveals fungal disease responsive core gene regulatory landscape in tea
Hazra, Scientific reports 2023 - “...investigated with this sequence in The Arabidopsis Information Resource (TAIR) database, it revealed homology with AT4G37990, the elicitor-activated gene 32 (ELI3-2). ELI3-2 encodes aromatic alcohol: NADP+oxidoreductase, the expression of which increases in response to phytopathogenic bacteria. This enzyme does not have mannitol dehydrogenase activity despite the...”
- cDNA Transcriptome of Arabidopsis Reveals Various Defense Priming Induced by a Broad-Spectrum Biocontrol Agent Burkholderia sp. SSG
Kong, International journal of molecular sciences 2022 - “...and AT2G26910 had 4 isoforms, AT3G19960 had three isoforms and AT4G29010, AT4G32410, AT5G65780, AT5G46020, and AT4G37990 had two isoforms. Genes with different isoforms at 24 hpt ( Figure S4 ) included AT5G17920, AT5G13740, and AT2G12400 with four isoforms, AT2G47070, AT2G27720, AT5G14060, and AT4G14210 with three isoforms,...”
- “...and relations to defense priming. For example, AT3G59930 encoding a defensin-such as protein, DEFL, and AT4G37990 ELI3-2 Defensins ( Table 2 ) have recently been shown to confer broad-spectrum resistance to pathogens in crops [ 65 ]. DEFL functions at iron and zinc homeostasis and stress...”
- Endophytic bacterium Bacillus aryabhattai induces novel transcriptomic changes to stimulate plant growth
Xu, PloS one 2022 - “...genes during the B . aryabhattai -Arabidopsis interaction. ID Log2(Fold Change) a Description Upregulated genes AT4G37990 14983.5 Cinnamyl alcohol dehydrogenase AT1G14250 2685.5 Apyrase AT1G69880 2444.7 Thioredoxin H8 AT1G04580 2166.9 Benzaldehyde dehydrogenase AT2G30770 2092.8 Indoleacetaldoxime dehydratase AT1G26390 2018.8 Berberine bridge enzyme-like AT3G02885 1666.9 Gibberellin-regulated protein ATCG00040 12.3...”
- “...3. Please clarify the cutoff RPKM value. Could you explain the data from Table 1 AT4G37990, log2(Fold change) = 14983.5? 4. In the results part, there is no analysis and conclusion for the RNAseq data. It is not helpful for readers to understand the meanings of...”
- Plant biomechanics and resilience to environmental changes are controlled by specific lignin chemistries in each vascular cell type and morphotype
Ménard, The Plant cell 2022 - “...(OMT1): At5g54160/CINNAMOYL-COA REDUCTASE 1 (CCR1): At1g15950/CINNAMYL ALCOHOL DEHYDROGENASE 4 (CAD4): At4g37980/CINNAMYL ALCOHOL DEHYDROGENASE 5 (CAD5): At4g37990. Supplemental data The following materials are available in the online version of this article. Supplemental Figure S1 . Introduction to basic physiological concepts of water conduction in TEs. Supplemental Figure...”
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- Physcomitrium patens CAD1 has distinct roles in growth and resistance to biotic stress
Jiang, BMC plant biology 2022 - “...proteins used to build the tree are: Arabidopsis thaliana AtCAD1 (NP_195643); AtCAD2 (NP_195510); AtCAD3(CAA48027); AtCAD4 (NP_195512); AtCAD5 (NP_188576); AtCAD6 (NP_195149); AtCAD7 (NP_179765); AtCAD8 (NP_179780); AtCAD9 (NP_177412); Populus tremuloides PtCAD1 (AAF43140); PtCAD2 (AAK58693);PtCAD3 (AAK58693); PtCAD4 (AAK58693); PtCAD5 (AAK58693); PtCAD6 (AAK58693); PtCAD7 (AAK58693); PtCAD8 (AAK58693) PtCAD9 (AAK58693); Oryza...”
- Genome-wide identification of the CAD gene family and functional analysis of putative bona fide CAD genes in tobacco (Nicotiana tabacum L.)
Wu, Frontiers in plant science 2024 - “...and Nsyl); Arabidopsis thaliana , AtCAD19 (accession number: Q9CAI3, Q9SJ25, Q9SJ10, P48523, O49482, O65621, Q02971, Q02972, P42734); Oryza sativa , OsCAD19 (Q8H859, Q6ZHS4, Q337Y2, Q2R114, Q0J6T3, Q7XWU3, Q0JA75, Q6ERX1, Q10PS6); Brachypodium distachyon , BdCAD3 (AFK80371), BdCAD5 (AFK80372); Triticum aestivum , TaCAD1 (GU563724); Elaeis guineensis , EgCAD1...”
- Spore Germination of the Obligate Biotroph Spongospora subterranea: Transcriptome Analysis Reveals Germination Associated Genes.
Balotf, Frontiers in microbiology 2021 - “...TCONS_00002390 P16905 cAMP-dependent protein kinase type I regulatory subunit TCONS_00011972 P71741 Trehalase (EC 3.2.1.28) TCONS_00010927 Q02972 Cinnamyl alcohol dehydrogenase 8 (EC 1.1.1.195) TCONS_00004841 A0A0H5QK57 DDE-1 domain-containing protein TCONS_00000359 Q17551 E3 ubiquitin-protein ligase rpm-1 (EC 2.3.2.33) The annotation for unigenes was retrieved from the UniProt and NCBI...”
- Protein Changes in Response to Lead Stress of Lead-Tolerant and Lead-Sensitive Industrial Hemp Using SWATH Technology.
Xia, Genes 2019 - “...were upregulated in Y1, including acidic endochitinase, basic endochitinase B (P19171), cinnamyl alcohol dehydrogenase 8 (Q02972), patatin-like protein 2 (O48723) and tetratricopeptide repeat (TPR)-like superfamily protein (Q94K88). The first three are involved in the repair of the cell membrane structure [ 58 ]. Protein plant cadmium...”
CAD7 / Q02971 cinnamyl alcohol dehydrogenase 7 (EC 1.1.1.195) from Arabidopsis thaliana (see 2 papers)
CADH7_ARATH / Q02971 Cinnamyl alcohol dehydrogenase 7; AtCAD7; Cinnamyl alcohol dehydrogenase-like protein B; EC 1.1.1.195 from Arabidopsis thaliana (Mouse-ear cress) (see 3 papers)
NP_195511 cinnamyl alcohol dehydrogenase 7 from Arabidopsis thaliana
AT4G37980 ELI3-1 (ELICITOR-ACTIVATED GENE 3-1); binding / catalytic/ oxidoreductase/ zinc ion binding from Arabidopsis thaliana
47% identity, 97% coverage
- function: Involved in lignin biosynthesis. Catalyzes the final step specific for the production of lignin monomers. Catalyzes the NADPH- dependent reduction of coniferaldehyde, 5-hydroxyconiferaldehyde, sinapaldehyde, 4-coumaraldehyde and caffeyl aldehyde to their respective alcohols.
catalytic activity: (E)-cinnamyl alcohol + NADP(+) = (E)-cinnamaldehyde + NADPH + H(+) (RHEA:10392)
cofactor: Zn(2+) (Binds 2 Zn(2+) ions per subunit.)
subunit: Homodimer. - Identification of a Hexenal Reductase That Modulates the Composition of Green Leaf Volatiles.
Tanaka, Plant physiology 2018 - GeneRIF: This study shows that reductases play significant roles in changing Green leaf volatiles (GLVs) composition and, thus, are important in avoiding toxicity from volatile carbonyls and in the attraction of herbivore predators.
- Genome-wide identification of the CAD gene family and functional analysis of putative bona fide CAD genes in tobacco (Nicotiana tabacum L.)
Wu, Frontiers in plant science 2024 - “...Ntom, and Nsyl); Arabidopsis thaliana , AtCAD19 (accession number: Q9CAI3, Q9SJ25, Q9SJ10, P48523, O49482, O65621, Q02971, Q02972, P42734); Oryza sativa , OsCAD19 (Q8H859, Q6ZHS4, Q337Y2, Q2R114, Q0J6T3, Q7XWU3, Q0JA75, Q6ERX1, Q10PS6); Brachypodium distachyon , BdCAD3 (AFK80371), BdCAD5 (AFK80372); Triticum aestivum , TaCAD1 (GU563724); Elaeis guineensis ,...”
- Different combinations of laccase paralogs nonredundantly control the amount and composition of lignin in specific cell types and cell wall layers in Arabidopsis
Blaschek, The Plant cell 2023 - “...for the genes discussed in this article are as follows: F5H1 (At4g36220), CCR1 (At1g15950); CAD4 (At4g37980); CAD5 (At4g37990); XCP1 (At4g35350); XCP2 (At1g20850) CesA7/IRX3 (At5g17420); LAC1 (At1g18140); LAC2 (At2g29130); LAC3 (At2g30210); LAC4/IRX12 (At2g38080); LAC5 (At2g40370); LAC6 (At2g46570); LAC7 (At3g09220); LAC8 (At5g01040); LAC9 (At5g01050); LAC10 (At5g01190); LAC11 (At5g03260);...”
- Jasmonates and Histone deacetylase 6 activate Arabidopsis genome-wide histone acetylation and methylation during the early acute stress response
Vincent, BMC biology 2022 - “...superfamily (AT4G26220); FAD-binding Berberine family protein member, cinnamyl-alcohol dehydrogenases (AT1G30760) and ELI3-1 (cinnamyl-alcohol dehydrogenase 7 (AT4G37980). Several members of the peroxidase superfamily linked to phenylpropanoid/monolignols biosynthesis and stress responses [ 89 , 90 ] were also enriched: PR9 (AT1G05240), PRX2 (AT1G05250), RCI3 (RARE COLD INDUCIBLE GENE...”
- Molecular mechanisms of resistance to Myzus persicae conferred by the peach Rm2 gene: A multi-omics view
Le, Frontiers in plant science 2022 - “...C3H; p-coumaroylshikimate/quinate 3-hydrolxylase Prupe_8G135300 AT3G19450 78 Yes 1.6 2.40E-06 CAD4; Cinnamyl alcohol dehydrogenase 4 Prupe_6G207700 AT4G37980 75 No 9.1 1.10E-11 CAD7; Cinnamyl alcohol dehydrogenase 7 Prupe_1G003000 AT5G13930 85 Yes -2.0 6.80E-06 CHS; Chalcone synthase Prupe_2G225200 AT3G55120 71 Yes -2.6 7.30E-29 Chalcone isomerase Prupe_1G376400 AT5G42800 70 Yes...”
- CAD Genes: Genome-Wide Identification, Evolution, and Their Contribution to Lignin Biosynthesis in Pear (Pyrus bretschneideri)
Qi, Plants (Basel, Switzerland) 2021 - “...25 September 2019). Nine CAD protein sequences of Arabidopsis (AT1G72680, AT2G21730, AT2G21890, AT3G19450, AT4G34230, AT4G37970, AT4G37980, AT4G37990, and AT4G39330) were downloaded from The Arabidopsis Information Resource ( http://www.arabidopsis.org/ , 25 September 2019) and used as queries to perform a BLAST search against the four Rosaceae genome...”
- ROS/RNS Balancing, Aerobic Fermentation Regulation and Cell Cycle Control - a Complex Early Trait ('CoV-MAC-TED') for Combating SARS-CoV-2-Induced Cell Reprogramming
Costa, Frontiers in immunology 2021 - “...(AT5G13930.1)], C3H (p-coumarate 3-hdroxylase) (AT2G40890.1), CAD (cinnamyl alcohol dehydrogenase) [ CAD4 (At3g19450); CAD5 (At4g34230); CAD7 (At4g37980); CAD8 (At4g37990)], total NR (nitrate reductase) [ NIA1 (AT1G77760.1); NIA2 (AT1G37130.1)], ADH2 (AT5G43940.2), total ACT (actin) [ ACT1 (AT2G37620.1); ACT2 (AT3G18780.1); ACT3 (AT3G53750.1); ACT4 (AT5G59370.1); ACT7 (AT5G09810.1); ACT8 (AT1G49240.1); ACT9...”
- ROS/RNS balancing, aerobic fermentation regulation and cell cycle control – a complex early trait (‘CoV-MAC-TED’) for combating SARS-CoV-2-induced cell reprogramming
Costa, 2021 - Comparative Analyses of Phyllosphere Bacterial Communities and Metabolomes in Newly Developed Needles of Cunninghamia lanceolata (Lamb.) Hook. at Four Stages of Stand Growth
Sun, Frontiers in plant science 2021 - “...with SM15, including 4-coumarateCoA ligase 1(4CL1) (at3g21230 and at1g20500), elicitor-activated gene 3-2 (ELI3-2) (at4g37990 and at4g37980), and cinnamyl alcohol dehydrogenase (at4g37970, at4g34230, at4g34230, and at2g21730). In SM35, more than half of DEGs were down-regulated compared with SM15 ( Supplementary Table 3 ). Discussion Analysis of Chinese...”
- Using Gene Expression to Study Specialized Metabolism-A Practical Guide
Delli-Ponti, Frontiers in plant science 2020 - “...entered the 14 ( AT2G37040, AT3G10340, AT3G53260, AT5G04230, AT2G30490, AT1G72680, AT2G21730, AT2G21890, AT3G19450, AT4G34230, AT4G37970, AT4G37980, AT4G37990 , and AT4G39330 ) genes into the Tools/Heatmap/Comparative 2 , which revealed the expression profiles of these genes in organs of Arabidopsis . The resulting heatmap was pasted into...”
- More
LOC107953373 cinnamyl alcohol dehydrogenase 1 from Gossypium hirsutum
45% identity, 96% coverage
Q2R114 Putative cinnamyl alcohol dehydrogenase 4 from Oryza sativa subsp. japonica
45% identity, 97% coverage
- Genome-wide identification of the CAD gene family and functional analysis of putative bona fide CAD genes in tobacco (Nicotiana tabacum L.)
Wu, Frontiers in plant science 2024 - “...Q9SJ25, Q9SJ10, P48523, O49482, O65621, Q02971, Q02972, P42734); Oryza sativa , OsCAD19 (Q8H859, Q6ZHS4, Q337Y2, Q2R114, Q0J6T3, Q7XWU3, Q0JA75, Q6ERX1, Q10PS6); Brachypodium distachyon , BdCAD3 (AFK80371), BdCAD5 (AFK80372); Triticum aestivum , TaCAD1 (GU563724); Elaeis guineensis , EgCAD1 (UTE99576), EgCAD (XP_010943210); Medicago sativa , MsCAD1 (O82515), MsCAD2...”
G3DSC5 cinnamyl-alcohol dehydrogenase (EC 1.1.1.195) from Liriodendron tulipifera (see paper)
45% identity, 96% coverage
jhp1429 ZINC-DEPENDENT ALCOHOL DEHYDROGENASE from Helicobacter pylori J99
42% identity, 96% coverage
XP_003543132 probable cinnamyl alcohol dehydrogenase 1 from Glycine max
46% identity, 97% coverage
XP_007199637 probable cinnamyl alcohol dehydrogenase 1 from Prunus persica
43% identity, 96% coverage
LOC101250635 cinnamyl alcohol dehydrogenase 1 from Solanum lycopersicum
46% identity, 96% coverage
Sb02g024220 No description from Sorghum bicolor
47% identity, 82% coverage
- The cinnamyl alcohol dehydrogenase gene family in melon (Cucumis melo L.): bioinformatic analysis and expression patterns
Jin, PloS one 2014 - “...SbCAD4-2 (Sb10g006300), SbCAD4-3 (Sb10g006290), SbCAD4-4 (Sb10g006280), SbCAD4-5 (Sb10g006270), SbCAD5 (Sb07g006090), SbCAD6 (Sb06g001430), SbCAD7 (Sb06g028240), SbCAD8-1 (Sb02g024220), SbCAD8-2 (Sb02g024210), and SbCAD8-4 (Sb02g024190); Triticum aestivum : TaCAD1 (GU563724), TaCAD2 (TC143210), TaCAD3 (TC143265), TaCAD4 (TC144004), TaCAD5 (TC149391), TaCAD6 (TC149393), TaCAD7 (TC170425), TaCAD8 (TC170426), TaCAD9 (TC170429), TaCAD10 (TC172690), and TaCAD11...”
- Functional analysis of a cinnamyl alcohol dehydrogenase involved in lignin biosynthesis in wheat
Ma, Journal of experimental botany 2010 - “...SbCAD4-2 (Sb10g006300), SbCAD4-3 (Sb10g006290), SbCAD4-4 (Sb10g006280), SbCAD4-5 (Sb10g006270), SbCAD5 (Sb07g006090), SbCAD6 (Sb06g001430), SbCAD7 (Sb06g028240), SbCAD8-1 (Sb02g024220), SbCAD8-2 (Sb02g024210), and SbCAD8-4 (Sb02g024190); Triticum aestivum : TaCAD1 (GU563724), TaCAD2 (TC143210), TaCAD3 (TC143265), TaCAD4 (TC144004), TaCAD5 (TC149391), TaCAD6 (TC149393), TaCAD7 (TC170425), TaCAD8 (TC170426), TaCAD9 (TC170429), TaCAD10 (TC172690), and TaCAD11...”
CAD1_CAPAN / B5LAT8 Cinnamyl alcohol dehydrogenase 1; CaCAD1; Vanillyl alcohol synthase; EC 1.1.1.195; EC 1.1.1.- from Capsicum annuum (Capsicum pepper) (see paper)
45% identity, 96% coverage
- function: Involved in the biosynthesis of capsinoids natural products (e.g. capsiate), non-pungent alkaloids synthesized from phenylpropanoid intermediates in the placental tissue of sweet chili pepper fruit acting as repellant on herbivorous mammals (PubMed:19553373, PubMed:35858994). Catalyzes the reduction of vanillin to generate vanillyl alcohol, a precursor of capsiate, a non-pungent component that accumulates mainly in the placenta of mature red fruits, but also in green fruits to lower levels (PubMed:35858994). Involved in lignin biosynthesis (By similarity). Catalyzes the final step specific for the production of lignin monomers (By similarity). Mediates the conversion of cinnamaldehyde and coniferaldehyde to cinnamyl alcohol and coniferyl alcohol, respectively (PubMed:35858994). Catalyzes the NADPH-dependent reduction of 5-hydroxyconiferaldehyde, sinapaldehyde, 4-coumaraldehyde and caffeyl aldehyde to their respective alcohols (By similarity).
catalytic activity: (E)-cinnamyl alcohol + NADP(+) = (E)-cinnamaldehyde + NADPH + H(+) (RHEA:10392)
catalytic activity: (E)-coniferol + NADP(+) = (E)-coniferaldehyde + NADPH + H(+) (RHEA:22444)
catalytic activity: (E)-sinapyl alcohol + NADP(+) = (E)-sinapaldehyde + NADPH + H(+) (RHEA:45704)
catalytic activity: (E)-4-coumaroyl alcohol + NADP(+) = (E)-4-coumaraldehyde + NADPH + H(+) (RHEA:45724)
catalytic activity: (E)-caffeyl alcohol + NADP(+) = (E)-caffeyl aldehyde + NADPH + H(+) (RHEA:45728)
catalytic activity: vanillin + NADPH + H(+) = 4-hydroxy-3-methoxy-benzenemethanol + NADP(+) (RHEA:76611)
cofactor: Zn(2+) (Binds 2 Zn(2+) ions per subunit.)
subunit: Homodimer.
A0A0R0F139 Enoyl reductase (ER) domain-containing protein from Glycine max
48% identity, 96% coverage
LOC107816761 probable cinnamyl alcohol dehydrogenase 2 from Nicotiana tabacum
P30360 Probable cinnamyl alcohol dehydrogenase 2 from Nicotiana tabacum
46% identity, 96% coverage
- Cloning and overexpression of PeWRKY31 from Populus × euramericana enhances salt and biological tolerance in transgenic Nicotiana
Yu, BMC plant biology 2021 - “...1#: LOC107782952; 2#: LOC107798207; 3#: LOC107831218; 4#: LOC107768362; 5#: LOC107824233; 6#: LOC107832641; 7#: LOC107770091; 8#: LOC107816761; TD: Relative expression level of RNA-seq result. TD refers to the ratio of gene expression between the treatment and control groups. After treatmented with difference analysis software shrinkage model, the...”
- Quantitative Proteomic Analysis Provides Novel Insights into Cold Stress Responses in Petunia Seedlings.
Zhang, Frontiers in plant science 2016 - “...M1C0V6 Fructose-bisphosphate aldolase Up 0.0097 M1CXI6 Aspartate aminotransferase Up 0.0108 M1D227 Carbonic anhydrase Up 0.0352 P30360 Probable cinnamyl alcohol dehydrogenase 2 Up 0.0165 P32111 Probable glutathione S-transferase Up 0.0458 P48498 S-adenosylmethionine synthase 1 Up 0.0241 P61046 Cytochrome b6-f complex subunit 8 Up 0.0316 Q07346 Glutamate decarboxylase...”
- “...were found to be induced by cold stress. One was a cinnamyl alcohol dehydrogenase (CAD) (P30360) and the other was a putative expansin (Q8S346). The plant CW forms a barrier against pathogen attack and interconnects cells, and thereby plays a variety of distinct, sometimes opposite, roles....”
M1CF76 Cinnamyl alcohol dehydrogenase from Solanum tuberosum
LOC102602480 probable cinnamyl alcohol dehydrogenase 1 from Solanum tuberosum
46% identity, 96% coverage
Q6ERW9 Probable cinnamyl alcohol dehydrogenase 8B from Oryza sativa subsp. japonica
48% identity, 78% coverage
- Polymyxin B1 and E2 From Paenibacillus polymyxa Y-1 for Controlling Rice Bacterial Disease
Yi, Frontiers in cellular and infection microbiology 2022 - “...and 2 downregulated ones (A0A0P0V2C2, Q9AS12) involved in the regulation of POD. Meanwhile, CAD (Q8H859, Q6ERW9, and Q6ERW7) and GLU (Q60DX8) proteins were upregulated, but CYP73A (A2Y375) was downregulated ( Figure8 ). It is well-known that POD and CAD are able to regulate the formation of...”
- “...of Q94DM2 and Q6ZCC2 protein was 9.89 and 8.34, respectively. Expression levels of Q8H859 and Q6ERW9 of CAD upregulated 2.34-fold and 2.19-fold versus CK groups. Among DEPs of phenylpropanoid biosynthesis pathway, A0A0P0V2C2, Q9AS12, and A2Y375 were downregulated. The PRM results demonstrated that polymyxin B 1 could...”
- Proteomic Analysis of MeJa-Induced Defense Responses in Rice against Wounding
Bertini, International journal of molecular sciences 2019 - “...this group of proteins, we found a probable cinnamyl alcohol dehydrogenase 8B (OsCAD8B) (UniProt code Q6ERW9, Table 1 ), involved in lignin biosynthesis catalyzing the final step of the production of lignin monomers [ 55 ]. Interestingly, it has been reported that CAD genes are also...”
- “...B7EKW3 LOC_Os07g26690 Aquaporin 1.18 0.03 Q5Z5A8 LOC_Os06g51330 Photosystem II stability/assembly factor HCF136 chloroplastic 1.32 0.045 Q6ERW9 LOC_Os09g23540 Probable cinnamyl alcohol dehydrogenase 8B 1.36 0.041 Q7F8S5 LOC_Os02g09940 Peroxiredoxin-2E-2, chloroplastic 1.64 0.029 B9FY06 LOC_Os07g38300 Ribosome-recycling factor, chloroplastic 1.89 0.014 H2KW47 LOC_Os11g13890 Chlorophyll A-B binding protein, chloroplastic 1.94 0.014...”
7cguA / A0A8A5L0G9 Crystal structure of abhar
46% identity, 97% coverage
XP_025620500 probable cinnamyl alcohol dehydrogenase from Arachis hypogaea
44% identity, 95% coverage
- Anther dehiscence is regulated by gibberellic acid in yellow lupine (Lupinus luteus L.)
Marciniak, BMC plant biology 2021 - “...(XP_003555961); Ss - Spatholobus suberectus (TKY50969); Ck - Caragana korshinskii (AEV93476); Ah - Arachis hypogaea (XP_025620500); Ad - Arachis duranensis (XP_015941997); Ai - Arachis ipaensis (XP_016175492); In - Ipomoea nil (XP_019169368); Mt - Medicago truncatula (XP_013470061); Cc - Cajanus cajan (XP_020210039); At - Arabidopsis thaliana (AAK44076)....”
XP_016175492 probable cinnamyl alcohol dehydrogenase from Arachis ipaensis
44% identity, 95% coverage
- Anther dehiscence is regulated by gibberellic acid in yellow lupine (Lupinus luteus L.)
Marciniak, BMC plant biology 2021 - “...(AEV93476); Ah - Arachis hypogaea (XP_025620500); Ad - Arachis duranensis (XP_015941997); Ai - Arachis ipaensis (XP_016175492); In - Ipomoea nil (XP_019169368); Mt - Medicago truncatula (XP_013470061); Cc - Cajanus cajan (XP_020210039); At - Arabidopsis thaliana (AAK44076). Fig. S1 d. Comparison of CAD proteins derived from different...”
- “...(AEV93476); Ah - Arachis hypogaea (XP_025620500); Ad - Arachis duranensis (XP_015941997); Ai - Arachis ipaensis (XP_016175492); In - Ipomoea nil (XP_019169368); Mt - Medicago truncatula (XP_013470061); Cc - Cajanus cajan (XP_020210039); At - Arabidopsis thaliana (AAK44076). Fig. S2 a. LlCesA8 (alternative name LlIRX1) cDNA (GenBank accession...”
XP_015941997 probable cinnamyl alcohol dehydrogenase from Arachis duranensis
44% identity, 95% coverage
- Anther dehiscence is regulated by gibberellic acid in yellow lupine (Lupinus luteus L.)
Marciniak, BMC plant biology 2021 - “...(TKY50969); Ck - Caragana korshinskii (AEV93476); Ah - Arachis hypogaea (XP_025620500); Ad - Arachis duranensis (XP_015941997); Ai - Arachis ipaensis (XP_016175492); In - Ipomoea nil (XP_019169368); Mt - Medicago truncatula (XP_013470061); Cc - Cajanus cajan (XP_020210039); At - Arabidopsis thaliana (AAK44076). Fig. S1 d. Comparison of...”
- “...(TKY50969); Ck - Caragana korshinskii (AEV93476); Ah - Arachis hypogaea (XP_025620500); Ad - Arachis duranensis (XP_015941997); Ai - Arachis ipaensis (XP_016175492); In - Ipomoea nil (XP_019169368); Mt - Medicago truncatula (XP_013470061); Cc - Cajanus cajan (XP_020210039); At - Arabidopsis thaliana (AAK44076). Fig. S2 a. LlCesA8 (alternative...”
P30359 Probable cinnamyl alcohol dehydrogenase 1 from Nicotiana tabacum
46% identity, 95% coverage
- Metabolic networking in Brunfelsia calycina petals after flower opening
Bar-Akiva, Journal of experimental botany 2010 - “...(1.0763.65) (68418.m05207) O -Methyltransferase N-terminus domain-containing protein contains Pfam profile PF02409: Lignification STMIX91 2.322 (0.1264.496) (P30359) Cinnamyl-alcohol dehydrogenase (CAD) (EC 1.1.1.195) Lignification STMIJ60 2.267 (1.6623.439) (Q9SXJ0) Transcription factor Ntlim1 Lignification/zinc binding STMHR20 2.151 (1.6573.4) Adenosine monophosphate-binding protein 7 (AMPBP7_) Acyl Co-A synthase/secondary metabolite biosynthesis STMGM34 2.113...”
- Transcriptomic and metabolite analyses of Cabernet Sauvignon grape berry development.
Deluc, BMC genomics 2007 - “...3 3.36 1613548_at CB009193 TC68990 Q8H8C9 4-coumarate:CoA ligase Phenolic Acid 11 3.19 1615439_at CF213244 TC63112 P30359 Cinnamyl alcohol dehydrogenase 2 Phenolic Acid 2 2.38 1609327_at CF208599 TC68572 A1YIQ2 Cinnamyl-alcohol dehydrogenase 1 Phenolic Acid 2 2.33 1607163_at CF415171 - Q8LSQ3 4-coumarate:CoA ligase Phenolic Acid 3 2.22 1613511_at...”
M5WBG4 Enoyl reductase (ER) domain-containing protein from Prunus persica
48% identity, 94% coverage
Q6ERX1 Probable cinnamyl alcohol dehydrogenase 8A from Oryza sativa subsp. japonica
49% identity, 95% coverage
- Genome-wide identification of the CAD gene family and functional analysis of putative bona fide CAD genes in tobacco (Nicotiana tabacum L.)
Wu, Frontiers in plant science 2024 - “...O65621, Q02971, Q02972, P42734); Oryza sativa , OsCAD19 (Q8H859, Q6ZHS4, Q337Y2, Q2R114, Q0J6T3, Q7XWU3, Q0JA75, Q6ERX1, Q10PS6); Brachypodium distachyon , BdCAD3 (AFK80371), BdCAD5 (AFK80372); Triticum aestivum , TaCAD1 (GU563724); Elaeis guineensis , EgCAD1 (UTE99576), EgCAD (XP_010943210); Medicago sativa , MsCAD1 (O82515), MsCAD2 (P31656); Morus alba ,...”
- Proteomic response of hybrid wild rice to cold stress at the seedling stage
Wang, PloS one 2018 - “...Cysteine proteinase inhibitor (Fragment) 2.28 Q8LMR0 Phosphoserine aminotransferase 1.69 Q5N8G1 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase, chloroplastic 1.64 Q6ERX1 Probable cinnamyl alcohol dehydrogenase 8A 1.56 Q69U53 MAP3K-like protein 1.54 Q0DYB1 Soluble inorganic pyrophosphatase 1.54 Q2QLY4 5-methyltetrahydropteroyltriglutamatehomocysteine methyltransferase 2 0.67 Q2QQ48 Eukaryotic translation initiation factor 5A 0.66 Q6ESI7 Tripeptidyl-peptidase 2...”
Q10PS6 Probable cinnamyl alcohol dehydrogenase 9 from Oryza sativa subsp. japonica
46% identity, 95% coverage
- Genome-wide identification of the CAD gene family and functional analysis of putative bona fide CAD genes in tobacco (Nicotiana tabacum L.)
Wu, Frontiers in plant science 2024 - “...Q02971, Q02972, P42734); Oryza sativa , OsCAD19 (Q8H859, Q6ZHS4, Q337Y2, Q2R114, Q0J6T3, Q7XWU3, Q0JA75, Q6ERX1, Q10PS6); Brachypodium distachyon , BdCAD3 (AFK80371), BdCAD5 (AFK80372); Triticum aestivum , TaCAD1 (GU563724); Elaeis guineensis , EgCAD1 (UTE99576), EgCAD (XP_010943210); Medicago sativa , MsCAD1 (O82515), MsCAD2 (P31656); Morus alba , MaCAD15...”
GRMZM2G700188 uncharacterized protein LOC100273263 from Zea mays
46% identity, 82% coverage
- Transcriptome Analysis Revealed the Key Genes and Pathways Involved in Seed Germination of Maize Tolerant to Deep-Sowing
Wang, Plants (Basel, Switzerland) 2022 - “...identified some key genes of phenylpropanoid biosynthesis, including F5H (ferulate-5-hydroxylase, AC210173.4_FG005 ), 1.1.1.195 (cinnamyl-alcohol dehydrogenase, GRMZM2G700188 ), 3.2.1.21 (beta-glucosidase, GRMZM5G810727 ) and 1.11.1.7 (peroxidase, GRMZM2G405459 ). Their final products are coumarinate, p-hydroxy-phenyl lignin, guaiacyl lignin, 5-hydroxy-guaiacyl lignin and syringyl lignin. In addition, based on the KEGG...”
- Proteomic Analysis of Silk Viability in Maize Inbred Lines and Their Corresponding Hybrids
Ma, PloS one 2015 - “...7:3401038034006572 2.40E-122 66 3.2 Zong3 gi|219973780 unnamed protein product [Zea mays] 38084.1/6.00 760 100 11 GRMZM2G700188 7:108416493108414610 2.30E-103 33 4.1 Lx9801 gi|224031021 unknown [Zea mays] 68688.9/5.36 1,230 100 18 GRMZM2G421857 4:235992822235986865 2.60E-308 34 9.8 Lx9801 gi|194708072 unknown [Zea mays] 68547.2/5.46 236 100 8 GRMZM2G033208 9:2279199522794986 1.10E-307...”
- A secreted Ustilago maydis effector promotes virulence by targeting anthocyanin biosynthesis in maize
Tanaka, eLife 2014 - “...ZmBx5, GRMZM2G063756; ZmBx8, GRMZM2G085054; Zm4CL, GRMZM2G075333, GRMZM2G054013; ZmCCR, GRMZM2G131205, GRMZM2G131836; ZmCAD, GRMZM2G046070, GRMZM5G844562, GRMZM2G167613, AC234163.1_FGP002, GRMZM2G700188, GRMZM2G118610. Funding Information This paper was supported by the following grants: Max Planck Society to Shigeyuki Tanaka, Thomas Brefort, Nina Neidig, Armin Djamei, Jrg Kahnt, Regine Kahmann. DFG Collaborative Research...”
GS1 / W8JWW7 geissoschizine synthase (EC 1.3.1.36) from Catharanthus roseus (see 2 papers)
GS_CATRO / W8JWW7 Geissoschizine synthase; CrGS; Alcohol dehydrogenase 14; CrADH14; EC 1.3.1.36 from Catharanthus roseus (Madagascar periwinkle) (Vinca rosea) (see 4 papers)
42% identity, 96% coverage
- function: Component of the seco-iridoid and derivatives monoterpenoid indole alkaloids (MIAs, e.g. catharanthine, tabersonine, vincadifformine, vindoline, vincristine, quinine and strychnine) biosynthesis pathway. Catalyzes iminium reduction on 4,21- dehydrogeissoschizine to produce 19E-geissoschizine, precursor of catharanthine and tabersonine derivatives (PubMed:29147812, PubMed:30256480). May also catalyze the production of reactive intermediate used by the HL1, HL2, HL3 and HL4 to form catharanthine, vincadifformine and tabersonine (PubMed:30256480).
catalytic activity: (19E)-geissoschizine + NADP(+) = 4,21-dehydrogeissoschizine + NADPH (RHEA:11376)
cofactor: Zn(2+) (Binds 2 Zn(2+) ions per subunit.)
subunit: Homodimer.
disruption phenotype: Accumulation of ajmalicine at the expense of catharanthine and vindoline production (PubMed:29147812, PubMed:30256480). Lower tabersonine-forming activity (PubMed:30256480).
CAD4 / P48523 cinnamyl alcohol dehydrogenase 4 (EC 1.1.1.195) from Arabidopsis thaliana (see paper)
CADH4_ARATH / P48523 Cinnamyl alcohol dehydrogenase 4; AtCAD4; Cinnamyl alcohol dehydrogenase C; EC 1.1.1.195 from Arabidopsis thaliana (Mouse-ear cress) (see 4 papers)
P48523 cinnamyl-alcohol dehydrogenase (EC 1.1.1.195) from Arabidopsis thaliana (see 3 papers)
AT3G19450 ATCAD4; cinnamyl-alcohol dehydrogenase from Arabidopsis thaliana
NP_188576 GroES-like zinc-binding alcohol dehydrogenase family protein from Arabidopsis thaliana
45% identity, 93% coverage
- function: Involved in lignin biosynthesis in the floral stem. Catalyzes the final step specific for the production of lignin monomers. Catalyzes the NADPH-dependent reduction of coniferaldehyde, 5- hydroxyconiferaldehyde, sinapaldehyde, 4-coumaraldehyde and caffeyl aldehyde to their respective alcohols.
catalytic activity: (E)-cinnamyl alcohol + NADP(+) = (E)-cinnamaldehyde + NADPH + H(+) (RHEA:10392)
catalytic activity: (E)-coniferol + NADP(+) = (E)-coniferaldehyde + NADPH + H(+) (RHEA:22444)
catalytic activity: (E)-sinapyl alcohol + NADP(+) = (E)-sinapaldehyde + NADPH + H(+) (RHEA:45704)
catalytic activity: (E)-4-coumaroyl alcohol + NADP(+) = (E)-4-coumaraldehyde + NADPH + H(+) (RHEA:45724)
catalytic activity: (E)-caffeyl alcohol + NADP(+) = (E)-caffeyl aldehyde + NADPH + H(+) (RHEA:45728)
cofactor: Zn(2+) (Binds 2 Zn(2+) ions per subunit.)
subunit: Homodimer.
disruption phenotype: Reduced lignin content and rigidity of the floral stems. - Genome-wide identification of the CAD gene family and functional analysis of putative bona fide CAD genes in tobacco (Nicotiana tabacum L.)
Wu, Frontiers in plant science 2024 - “...). Figure2 Alignment of NtCADs and bona fide Arabidopsis CADs. The bona fide AtCADs AtCAD4 (At3g19450) and AtCAD5 (At4g34230) were used as reference sequences. Zn-binding motifs are highlighted in red boxes, and the NADP(H)-binding motif is also indicated. The red and purple arrows denote the presence...”
- Mapping of major QTL and candidate gene analysis for hull colour in foxtail millet (Setaria italica (L.) P. Beauv.)
Guo, BMC genomics 2023 - “...(pathway_idKO00940), biosynthesis of secondary metabolites (pathway_idKO01110), and metabolic pathways (pathway_idKO01100). The Arabidopsis homolog of Seita.1G057300.1, AT3G19450, encodes a catalytically active cinnamyl alcohol dehydrogenase that acts as the primary gene involved in lignin biosynthesis in the floral stem of Arabidopsis thaliana by supplying both coniferyl and sinapyl...”
- PEAPOD repressors modulate and coordinate developmental responses to light intensity in Arabidopsis
White, The New phytologist 2022 - “..., PHE AMMONIA LYASE 1 (PAL1 , At2g37040) , CINNAMYL ALCOHOL DEHYDRASE4 ( CAD , At3g19450 ), CHORISMATE MUTASE1 ( CM1 , At3g29200 ), FLAVANONE 3HYDROXYLASE ( F3H , At3g51240 ), CHALCONE ISOMERASE ( CHI , At3g55120 ), CHALCONE ISOMERASE LIKE ( CHIL , At5g05270 ),...”
- The Arabidopsis T-DNA mutant SALK_008491 carries a 14-kb deletion on chromosome 3 that provides rare insights into the plant response to dynamic light stress
Lopez, Plant direct 2022 - “...Locus Molecular function according to TAIR10 SUBAsubcellular protein location At3G19440 Pseudouridine synthase family protein Mitochondrion At3G19450 ATCAD4, cinnamyl alcohol dehydrogenase 4 Cytosol At3G19460 ERassociated membrane protein of unknown function Plasma membrane At3G19470 Fbox and associated interaction domainscontaining protein Cytosol At3G19480 PGDH3 involved in the plastid phosphorylated...”
- Genome-wide analysis of the CAD gene family reveals two bona fide CAD genes in oil palm
Yusuf, 3 Biotech 2022 - “...Q6ZHS4, BdCAD5: Bradi3g06480 (Phytozome), AtCAD4: At3g19450 (Phytozome), AtCAD5: At4g34230 (Phytozome), EgCAD1: XP_010932224 and EgCAD2: XP_010943210. The...”
- Molecular mechanisms of resistance to Myzus persicae conferred by the peach Rm2 gene: A multi-omics view
Le, Frontiers in plant science 2022 - “...8.60E-06 HCT; Shikimate O-hydroxycinnamoyltransferase Prupe_1G580300 AT2G40890 80 No -2.1 4.20E-06 CYP98A3; C3H; p-coumaroylshikimate/quinate 3-hydrolxylase Prupe_8G135300 AT3G19450 78 Yes 1.6 2.40E-06 CAD4; Cinnamyl alcohol dehydrogenase 4 Prupe_6G207700 AT4G37980 75 No 9.1 1.10E-11 CAD7; Cinnamyl alcohol dehydrogenase 7 Prupe_1G003000 AT5G13930 85 Yes -2.0 6.80E-06 CHS; Chalcone synthase Prupe_2G225200...”
- Proteomic and metabolic disturbances in lignin-modified Brachypodium distachyon
Barros, The Plant cell 2022 - “...CCR1 Bradi3g36887 74 I1I7E4 N Moderate 0.80.05 Step 11: CAD: At CAD4 ( CAD-C ) At3g19450 Bd CAD1 Bradi3g06480 82 I1HY48 N High 8.01.0 At CAD5 ( CAD-D ) At4g34230 Bd CAD2 Bradi4g29780 64 I1IPY8 N Low 2.30.3 Step 12: PMT: Bd PMT1 Bradi2g36910 100 I1HM65...”
- A Metabolic Profiling Analysis Revealed a Primary Metabolism Reprogramming in Arabidopsis glyI4 Loss-of-Function Mutant
Proietti, Plants (Basel, Switzerland) 2021 - “...phenylalanine ammonia lyase 2 ( PAL2 , At3g53260), cinnamyl alcohol dehydrogenase 4 ( CAD4 , At3g19450), and 5-enolpyruvylshikimate-3-phosphate synthase ( EPSPS , At1g48860), in Col-8 and the glyI4 mutant. As shown in Figure 3 , the three genes were significantly downregulated in the glyI4 mutant compared...”
- “...The Arabidopsis gene identifier (AGI) numbers of the studied genes are AT3g53260 ( PAL2 ), AT3g19450 ( CAD4 ), AT1g48860 ( EPSPS ), At4g05320 ( UBI10 ). Primers were the following: PAL2 (Fw: AGGCAGCGTTAAGGTTGAGT; Rv: GGTGACTCCGTAACTGTCAGTAC), CAD4 (Fw: GACACCATGATCGTCAATCAAAAG; Rv: TCAACGGACTATAAACCGTTACTC), EPSPS (Fw: TGCTAAATGGTTCTGAGATTCGTC; Rv: AGACCCGAGATTTCTCTAAT...”
- More
- Physcomitrium patens CAD1 has distinct roles in growth and resistance to biotic stress
Jiang, BMC plant biology 2022 - “...to build the tree are: Arabidopsis thaliana AtCAD1 (NP_195643); AtCAD2 (NP_195510); AtCAD3(CAA48027); AtCAD4 (NP_195512); AtCAD5 (NP_188576); AtCAD6 (NP_195149); AtCAD7 (NP_179765); AtCAD8 (NP_179780); AtCAD9 (NP_177412); Populus tremuloides PtCAD1 (AAF43140); PtCAD2 (AAK58693);PtCAD3 (AAK58693); PtCAD4 (AAK58693); PtCAD5 (AAK58693); PtCAD6 (AAK58693); PtCAD7 (AAK58693); PtCAD8 (AAK58693) PtCAD9 (AAK58693); Oryza sativa OsCAD1...”
- Ancient origin of the biosynthesis of lignin precursors
Labeeuw, Biology direct 2015 - “...that have been biochemically characterized were used as queries. These protein sequences [NCBI: NP_179765, NCBI: NP_188576, NCBI: NP_173872, NCBI: NP_001077697, NCBI: NP_173047, NCBI: NP_181241, NCBI: NP_180607, NCBI: NP_199704, NCBI: NP_200227, NCBI: NP_850337, NCBI: NP_195345, NCBI: XP_002963471, NCBI: AAB09228, NCBI: XP_002992167] were used to query the National...”
- Manipulation of Guaiacyl and Syringyl Monomer Biosynthesis in an Arabidopsis Cinnamyl Alcohol Dehydrogenase Mutant Results in Atypical Lignin Biosynthesis and Modified Cell Wall Structure.
Anderson, The Plant cell 2015 - GeneRIF: Data show that disruption of the genes encoding both cinnamyl alcohol dehydrogenases CADC (At3g19450) and CADD (At4g34230) results in the atypical incorporation of hydroxycinnamaldehydes into lignin.
- The simultaneous repression of CCR and CAD, two enzymes of the lignin biosynthetic pathway, results in sterility and dwarfism in Arabidopsis thaliana.
Thévenin, Molecular plant 2011 (PubMed)- GeneRIF: Repressing both the CAD and the CCR activities results in sterility and dwarfism.
- Crystal structures and catalytic mechanism of the Arabidopsis cinnamyl alcohol dehydrogenases AtCAD5 and AtCAD4.
Youn, Organic & biomolecular chemistry 2006 (PubMed)- GeneRIF: determined the crystal structures of AtCAD5 in the apo-form and as a binary complex with NADP+, respectively, and modeled that of AtCAD4. The substrate-binding pockets of both AtCAD5 and AtCAD4 were also examined.
- Genome-wide identification of the CAD gene family and functional analysis of putative bona fide CAD genes in tobacco (Nicotiana tabacum L.)
Wu, Frontiers in plant science 2024 - “...include tobacco (Ntab, Ntom, and Nsyl); Arabidopsis thaliana , AtCAD19 (accession number: Q9CAI3, Q9SJ25, Q9SJ10, P48523, O49482, O65621, Q02971, Q02972, P42734); Oryza sativa , OsCAD19 (Q8H859, Q6ZHS4, Q337Y2, Q2R114, Q0J6T3, Q7XWU3, Q0JA75, Q6ERX1, Q10PS6); Brachypodium distachyon , BdCAD3 (AFK80371), BdCAD5 (AFK80372); Triticum aestivum , TaCAD1 (GU563724);...”
LOC103425085 probable cinnamyl alcohol dehydrogenase 1 from Malus domestica
45% identity, 96% coverage
- MdMYB66 Is Associated with Anthocyanin Biosynthesis via the Activation of the MdF3H Promoter in the Fruit Skin of an Apple Bud Mutant
Huang, International journal of molecular sciences 2023 - “...structural genes, including two up-regulated 4CL (LOC103427406, LOC103426517), one up-regulated F3H (LOC103436139), one down-regulated CAD (LOC103425085), one down-regulated CCR (LOC103943280), and one down-regulated POD (LOC103450728) were confirmed. In addition, six transcription factors (TFs), including four up-regulated MYB TFs (LOC103421948, LOC103455780, LOC103424517, LOC103431271) and two bHLH TFs...”
Redox1 / A0A2P1GIW4 Redox 1 from Catharanthus roseus (see paper)
REDX1_CATRO / A0A2P1GIW4 Protein REDOX 1; Cinnamyl alcohol dehydrogenase 4; EC 1.5.1.56 from Catharanthus roseus (Madagascar periwinkle) (Vinca rosea) (see 2 papers)
44% identity, 98% coverage
- function: Component of iboga and aspidosperma monoterpenoid indole alkaloids (MIAs, e.g. tabersonine and catharanthine) biosynthesis pathway from 19E-geissoschizine. Catalyzes the first oxidation step of the unstable intermediate product resulting from the reaction triggered by the geissoschizine oxidase (GO) in the stemmadenine biosynthesis process from 19E-geissoschizine.
catalytic activity: 3,17-didehydrostemmadenine + NADPH + H2O = (16S)- deshydroxymethyl-stemmadenine + formate + NADP(+) (RHEA:58524)
catalytic activity: 3,17-didehydrostemmadenine + NADPH + H2O = (16R)- deshydroxymethyl-stemmadenine + formate + NADP(+) (RHEA:58528)
catalytic activity: 17-dehydrostemmadenine + NADP(+) = 3,17-didehydrostemmadenine + NADPH (RHEA:58560)
cofactor: Zn(2+) (Binds 2 Zn(2+) ions per subunit.)
disruption phenotype: Reduced accumulation of catharanthine and vindoline, but accumulation of akuammicine and short-lived MIA.
Q6ERW7 Probable cinnamyl alcohol dehydrogenase 8C from Oryza sativa subsp. japonica
48% identity, 78% coverage
- iTRAQ based proteomic analysis of rice lines having single or stacked blast resistance genes: Pi54/Pi54rh during incompatible interaction with Magnaporthe oryzae
Kumari, Physiology and molecular biology of plants : an international journal of functional plant biology 2023 - “...of aldehyde dehydrogenase (Q6L5I4, Q69P84) and dehydrogenase (Q6ERW7, CADH1), three loci of betaglucosidase (A0A0P0WBJ3, Q10CU9, Q8W2Z2) and four loci of...”
- Polymyxin B1 and E2 From Paenibacillus polymyxa Y-1 for Controlling Rice Bacterial Disease
Yi, Frontiers in cellular and infection microbiology 2022 - “...downregulated ones (A0A0P0V2C2, Q9AS12) involved in the regulation of POD. Meanwhile, CAD (Q8H859, Q6ERW9, and Q6ERW7) and GLU (Q60DX8) proteins were upregulated, but CYP73A (A2Y375) was downregulated ( Figure8 ). It is well-known that POD and CAD are able to regulate the formation of lignin (...”
- “...0.60 0.43 0.00009 Q8H859 CAD1 0.63 1.37 2.17 0.00002 Q6ERW9 CAD8B 0.60 1.40 2.34 0.00026 Q6ERW7 CAD8C 0.69 1.31 1.88 0.00043 Q60DX8 BGLU22 0.86 1.14 1.33 0.00900 A2Y375 CYP73A 1.24 0.76 0.61 0.00098 Figure10 The fragment ion peak area distribution map of unique peptides of some...”
YL498_MIMIV / Q5UQG2 Probable zinc-type alcohol dehydrogenase-like protein L498; EC 1.-.-.- from Acanthamoeba polyphaga mimivirus (APMV) (see paper)
MIMI_L498 Zn-dependent alcohol dehydrogenase from Acanthamoeba polyphaga mimivirus
41% identity, 82% coverage
- cofactor: Zn(2+) (Binds 2 Zn(2+) ions per subunit.)
- Giant viruses, giant chimeras: the multiple evolutionary histories of Mimivirus genes
Moreira, BMC evolutionary biology 2008 - “...bacterial protein). The others are closer to proteobacterial sequences: e.g., ORFs MIMI_L477 (a cysteine protease), MIMI_L498 (a Zn-dependent alcohol dehydrogenase), and MIMI_R877 (outer membrane lipoprotein). The source of these bacterial-related ORFs is intriguing. The most appealing possibility is that Mimivirus has acquired them from bacteria that...”
- “...typical inhabitants of amoeba. That is the case of two of the ORFs cited above: MIMI_L498, related to Legionella pneumophila (Figure 2A ) and MIMI_R877, related to Campylobacter spp. (Figure 2B ), which are proteobacteria frequently found in different amoebas, including Acanthamoeba [ 33 - 35...”
- Mimivirus giant particles incorporate a large fraction of anonymous and unique gene products
Renesto, Journal of virology 2006 - “...E10R (C-C bonding) MIMI_R135 MIMI_R188 MIMI_R195 MIMI_R362 MIMI_R443 MIMI_L498 MIMI_L893 MIMI_L894 MIMI_R596 69, 70, 71, 72 10 NP 96 67 NP NP NP 87...”
A0A2Z5D8A5 cinnamyl-alcohol dehydrogenase (EC 1.1.1.195) from Artemisia annua (see paper)
43% identity, 95% coverage
D7PGW0 cinnamyl-alcohol dehydrogenase (EC 1.1.1.195) from Triticum aestivum (see paper)
46% identity, 95% coverage
8a3nB / W8JWW7 Geissoschizine synthase from catharanthus roseus - binary complex with NADP+ (see paper)
42% identity, 99% coverage
- Ligands: nadp nicotinamide-adenine-dinucleotide phosphate; zinc ion (8a3nB)
F6L7F4 cinnamyl-alcohol dehydrogenase (EC 1.1.1.195) from Camellia sinensis (see paper)
44% identity, 89% coverage
CAD1 / Q2KNL5 geraniol dehydrogenase (EC 1.1.1.183) from Ocimum basilicum (see paper)
CADH1_OCIBA / Q2KNL5 Cinnamyl alcohol dehydrogenase 1; CAD 1; ObaCAD1; EC 1.1.1.195 from Ocimum basilicum (Sweet basil) (see paper)
44% identity, 96% coverage
- function: Involved in the production of citral, a mixture of geranial and neral with a strong lemony scent. Reversibly oxidizes geraniol to produce geranial at half the efficiency compared with its activity with cinnamyl alcohol. Does not use nerol and neral as substrates.
catalytic activity: (E)-cinnamyl alcohol + NADP(+) = (E)-cinnamaldehyde + NADPH + H(+) (RHEA:10392)
catalytic activity: (E)-coniferol + NADP(+) = (E)-coniferaldehyde + NADPH + H(+) (RHEA:22444)
catalytic activity: (E)-sinapyl alcohol + NADP(+) = (E)-sinapaldehyde + NADPH + H(+) (RHEA:45704)
catalytic activity: (E)-4-coumaroyl alcohol + NADP(+) = (E)-4-coumaraldehyde + NADPH + H(+) (RHEA:45724)
catalytic activity: (E)-caffeyl alcohol + NADP(+) = (E)-caffeyl aldehyde + NADPH + H(+) (RHEA:45728)
cofactor: Zn(2+) (Binds 2 Zn(2+) ions per subunit.)
subunit: Homodimer. - De Novo Sequencing and Analysis of Lemongrass Transcriptome Provide First Insights into the Essential Oil Biosynthesis of Aromatic Grasses
Meena, Frontiers in plant science 2016 (no snippet)
T3R_CATRO / A0A161CAI1 16-methoxy-2,3-dihydro-3-hydroxytabersonine synthase; 3-hydroxy-1,2-didehydro-2,3-dihydrotabersonine reductase; Alcohol dehydrogenase-like protein 1; ADHL1; Tabersonine 3-reductase; EC 1.1.99.41 from Catharanthus roseus (Madagascar periwinkle) (Vinca rosea) (see 2 papers)
A0A161CAI1 3-hydroxy-1,2-didehydro-2,3-dihydrotabersonine reductase (EC 1.1.99.41) from Catharanthus roseus (see 2 papers)
40% identity, 99% coverage
- function: Converts the unstable imine alcohols produced by CYP71D1V2/T3O into 3-hydroxy-16-methoxy-2,3-dihydrotabersonine or 3- hydroxy-2,3-dihydrotabersonine.
catalytic activity: (3R)-3-hydroxy-16-methoxy-2,3-dihydrotabersonine + A = (3R)- 1,2-didehydro-3-hydroxy-16-methoxy-2,3-dihydrotabersonine + AH2 (RHEA:52484)
catalytic activity: (3R)-3-hydroxy-2,3-dihydrotabersonine + A = (3R)-1,2- didehydro-3-hydroxy-2,3-dihydrotabersonine + AH2 (RHEA:55388)
cofactor: Zn(2+) (Binds 2 Zn(2+) ions per subunit.)
T1WW82 cinnamyl-alcohol dehydrogenase (EC 1.1.1.195) from Populus tomentosa (see paper)
45% identity, 96% coverage
XP_007201367 cinnamyl alcohol dehydrogenase 1 from Prunus persica
44% identity, 96% coverage
NP_001105654 probable cinnamyl alcohol dehydrogenase from Zea mays
46% identity, 94% coverage
5fi3A / A0A0F6SD02 Heteroyohimbine synthase thas1 from catharanthus roseus - complex with NADP+ (see paper)
41% identity, 98% coverage
- Ligands: nadp nicotinamide-adenine-dinucleotide phosphate; zinc ion (5fi3A)
8b25B / A0A5B8X8Z0 Dihydroprecondylocarpine acetate synthase 2 from tabernanthe iboga - stemmadenine acetate bound structure (see paper)
45% identity, 95% coverage
- Ligands: stemmadenine acetate; zinc ion (8b25B)
CADH2_ORYSJ / Q6ZHS4 Cinnamyl alcohol dehydrogenase 2; OsCAD2; Protein GOLD HULL AND INTERNODE 2; EC 1.1.1.195 from Oryza sativa subsp. japonica (Rice) (see 3 papers)
Q6ZHS4 cinnamyl-alcohol dehydrogenase (EC 1.1.1.195) from Oryza sativa Japonica Group (see paper)
Q38G74 cinnamyl-alcohol dehydrogenase from Oryza sativa subsp. indica
46% identity, 94% coverage
- function: Involved in lignin biosynthesis (PubMed:16443696, PubMed:21912859). Catalyzes the final step specific for the production of lignin monomers. Catalyzes the NADPH-dependent reduction of coniferaldehyde and sinapaldehyde to their respective alcohols (PubMed:16443696). Plays the major role in monolignol biosynthesis. Functions cooperatively with COMT in the culm internodes for the biosynthesis of monolignols, the lignin precursors. May be involved in lignin biosynthesis in leaves and roots (PubMed:21912859).
catalytic activity: (E)-cinnamyl alcohol + NADP(+) = (E)-cinnamaldehyde + NADPH + H(+) (RHEA:10392)
catalytic activity: (E)-coniferol + NADP(+) = (E)-coniferaldehyde + NADPH + H(+) (RHEA:22444)
catalytic activity: (E)-sinapyl alcohol + NADP(+) = (E)-sinapaldehyde + NADPH + H(+) (RHEA:45704)
catalytic activity: (E)-4-coumaroyl alcohol + NADP(+) = (E)-4-coumaraldehyde + NADPH + H(+) (RHEA:45724)
catalytic activity: (E)-caffeyl alcohol + NADP(+) = (E)-caffeyl aldehyde + NADPH + H(+) (RHEA:45728)
cofactor: Zn(2+) (Binds 2 Zn(2+) ions per subunit.)
subunit: Homodimer.
disruption phenotype: Reduced lignin content, reddish-brown coloration of panicles and internodes, and golden yellow seeds. - Multiomics Analysis of the Mechanism by Which Gibberellin Alleviates S-Metolachlor Toxicity in Rice Seedlings
Wang, Plants (Basel, Switzerland) 2024 - “...1.5471 0.00138 0.9791 0.56018 1.5801 0.00053 probable 4-coumarateCoA ligase 4 [ Oryza sativa Japonica Group] Q38G74 1.4559 0.00286 0.8860 0.00106 1.6433 3.7 10 5 Cinnamyl-alcohol dehydrogenase OS = Oryza sativa subsp. indica OX = 39946 GN = GH2 PE = 3 SV = 1 A2WN51 2.3890...”
- Genome-wide identification of the CAD gene family and functional analysis of putative bona fide CAD genes in tobacco (Nicotiana tabacum L.)
Wu, Frontiers in plant science 2024 - “...number: Q9CAI3, Q9SJ25, Q9SJ10, P48523, O49482, O65621, Q02971, Q02972, P42734); Oryza sativa , OsCAD19 (Q8H859, Q6ZHS4, Q337Y2, Q2R114, Q0J6T3, Q7XWU3, Q0JA75, Q6ERX1, Q10PS6); Brachypodium distachyon , BdCAD3 (AFK80371), BdCAD5 (AFK80372); Triticum aestivum , TaCAD1 (GU563724); Elaeis guineensis , EgCAD1 (UTE99576), EgCAD (XP_010943210); Medicago sativa , MsCAD1...”
- Genome-wide analysis of the CAD gene family reveals two bona fide CAD genes in oil palm
Yusuf, 3 Biotech 2022 - “...ZmCAD2: CAA06687, SbCAD2: XP_021314961, OsCAD2: Q6ZHS4, BdCAD5: Bradi3g06480 (Phytozome), AtCAD4: At3g19450 (Phytozome), AtCAD5: At4g34230 (Phytozome), EgCAD1:...”
- Integrative Transcriptomic and Proteomic Analysis Reveals an Alternative Molecular Network of Glutamine Synthetase 2 Corresponding to Nitrogen Deficiency in Rice (Oryza sativa L.)
Liang, International journal of molecular sciences 2021 - “...biosynthesiswere also observed. For example, Os4CL5 catalyzes lignin subunits G/S formation [ 61 ]. OsCAD2 (Q6ZHS4) was the upregulated DAP that stimulates the last step of monolignol biosynthesis [ 62 ]. Therefore, lignin formation and cell wall modification are highly regulated as a result of root...”
- “...cytochrome P450 98A1 3.76 A2ZCW8 LOC_Os11g12760 O-methyltransferase ZRP4 3.53 B8AND5 LOC_Os03g05780 4-coumarate--CoA ligase-like 7 2.42 Q6ZHS4 LOC_Os02g09490 cinnamyl alcohol dehydrogenase 3.37 A0A0N7KK39 LOC_Os05g04470 peroxidase precursor 4.44 A2YHC0 LOC_Os07g01420 peroxidase 1 precursor 2.66 downregulated A2XZ41 LOC_Os04g58710 peroxisomal-coenzyme A synthetase 0.10 B8ARF5 LOC_Os04g57850 AMP-binding protein gene 0.11 B8AMG2...”
- De novo transcriptome analysis of white teak (Gmelina arborea Roxb) wood reveals critical genes involved in xylem development and secondary metabolism
Yaya, BMC genomics 2021 - “...Jre: Juglans regia (XP_018827699.1), Lp: Lolium perenne (AAB70908), Ote: Ocimum tenuiflorum (ADO16245.1), Os: Oryza sativa (Q6ZHS4), Pni: Populus nigra (AFR37935.1), Pto: Populus tomentosa (AAR83343.1), Rs: Rauvolfia serpentine (ALW82980.1), Sm: Salvia miltiorrhiza (ADN78309.1), Sin: Sesamum indicum (XP_011097452.1), She : Sinopodophyllum hexandrum (AEA36767.1), Tgr: Tectona grandis (ANG60951.1, ANG60952.1,...”
5h83A / A0A1C7D195 Heteroyohimbine synthase hys from catharanthus roseus - apo form (see paper)
42% identity, 99% coverage
I1HY48 cinnamyl-alcohol dehydrogenase (EC 1.1.1.195) from Brachypodium distachyon (see paper)
46% identity, 95% coverage
WS_STRYX / P0DXF9 Wieland-Gumlich aldehyde synthase; SpWS; EC 1.5.1.- from Strychnos sp. (see paper)
42% identity, 93% coverage
- function: Alcohol dehydrogenase involved in the biosynthesis of curare monoterpene indole alkaloids (MIAs), natural products such as diaboline, a pharmacologically active compound used to regulate blood pressure (PubMed:35794473). Curare alkaloids act as animal glycine receptor antagonists (PubMed:35794473). Catalyzes the conversion of norfluorocurarine to desoxy Wieland-Gumlich aldehyde, and of 18-OH norfluorocurarine to Wieland-Gumlich aldehyde (PubMed:35794473).
catalytic activity: (19E)-cur-19-en-17-al + NADP(+) = norfluorocurarine + NADPH + H(+) (RHEA:80903)
catalytic activity: 17,18-epoxy-17-hydroxycur-19-ene + NADP(+) = 18- hydroxynorfluorocurarine + NADPH + H(+) (RHEA:80911)
cofactor: Zn(2+) (Binds 2 Zn(2+) ions per subunit.)
subunit: Homodimer.
A1ILL4 cinnamyl-alcohol dehydrogenase (EC 1.1.1.195) from Sorghum bicolor (see 2 papers)
LOC110434683, XP_021314961 probable cinnamyl alcohol dehydrogenase from Sorghum bicolor
46% identity, 94% coverage
- Genome-wide analysis of the CAD gene family reveals two bona fide CAD genes in oil palm
Yusuf, 3 Biotech 2022 - “...sequences used are: ZmCAD2: CAA06687, SbCAD2: XP_021314961, OsCAD2: Q6ZHS4, BdCAD5: Bradi3g06480 (Phytozome), AtCAD4: At3g19450 (Phytozome), AtCAD5: At4g34230...”
- Suitability of target region amplified polymorphism (TRAP) markers to discern genetic variability in sweet sorghum
Khidr, Journal, genetic engineering & biotechnology 2020 - “...3) Tm Lignin-related genes Cinnamoyl coA reductase (CCR) LOC8054741 GTCAGGAACCCAGATGAC 55 Cinnamoyl alcohol dehydrogenase (CAD) LOC110434683 GGGCTTCAAAGTACCCTA 54 Caffeic acid 3-O-methyltransferase (COMT) LOC8070884 CAAGAAGCTCCTCGAGTT 54 Sucrose-related genes Sucrose synthase (susy) Sb01g033060 ATGGTATTCTCCGCAAGTGG 58 Soluble acid invertase (Inv) Sb04g000620 CATCGTTGCAGGGTATCCC 59 Sucrose phosphate synthase (sps) Sb05g007310 GCAAACCTTACGCTGATACTG...”
- The Enzyme Activity and Substrate Specificity of Two Major Cinnamyl Alcohol Dehydrogenases in Sorghum (Sorghum bicolor), SbCAD2 and SbCAD4.
Jun, Plant physiology 2017 - GeneRIF: two major CAD isoforms, SbCAD2 (Brown midrib 6 [bmr6]) and SbCAD4, in lignifying tissues of sorghum (Sorghum bicolor), indicates their similarity in both structure and activity to Arabidopsis (Arabidopsis thaliana) CAD5 and Populus tremuloides sinapyl alcohol dehydrogenase, respectively.
- Expression of brown-midrib in a spontaneous sorghum mutant is linked to a 5'-UTR deletion in lignin biosynthesis gene SbCAD2.
Li, Scientific reports 2017 - GeneRIF: The authors identified and cloned a novel cinnamyl alcohol dehydrogenase allele (SbCAD2) that has an 8-bp deletion in its 5'-untranslated region (UTR), conferring the spontaneous brown midrib trait and lignin reduction in the sorghum germplasm line PI 595743.
5h81B / A0A1C7D193 Heteroyohimbine synthase thas2 from catharanthus roseus - complex with NADP+ (see paper)
39% identity, 99% coverage
- Ligands: nadp nicotinamide-adenine-dinucleotide phosphate; zinc ion (5h81B)
RR4 / A0A0U3S9Q3 vomilenine 19,20-reductase from Rauvolfia serpentina (see paper)
44% identity, 95% coverage
ADHA_SYNY3 / P74721 Aldehyde reductase AdhA; Alcohol dehydrogenase AdhA; EC 1.1.1.2 from Synechocystis sp. (strain ATCC 27184 / PCC 6803 / Kazusa) (see 3 papers)
P74721 alcohol dehydrogenase (EC 1.1.1.1) from Synechocystis sp. PCC 6803 (see paper)
WP_010874320 NAD(P)-dependent alcohol dehydrogenase from Synechocystis sp. PCC 6803
slr1192 zinc-containing alcohol dehydrogenase family from Synechocystis sp. PCC 6803
39% identity, 97% coverage
- function: Active on a wide variety of primary alcohols and their corresponding aldehydes, but not against ketones nor secondary alcohols. Active on aliphatic compounds up to 5 carbons in length and aromatic alcohols, less effective on branched-chain primary alcohols. Prefers NADPH to NADH. Its catalytic efficiency is greatest for aldehydes, suggesting the reduction of aromatic and medium-chain aliphatic aldehydes is its in vivo activity (PubMed:19411329). Plays a role in tolerance to internally produced ethanol (PubMed:28160048).
catalytic activity: a primary alcohol + NADP(+) = an aldehyde + NADPH + H(+) (RHEA:15937)
cofactor: Zn(2+) (Zn(2+) and Co(2+) are equally efficient in vitro, Fe(2+) is less efficient.)
subunit: Homotetramer.
disruption phenotype: Unable to grow heterotrophically on glucose in the dark. Cells photobleach and have significantly reduced survival in 4% ethanol, reduced tolerance to internally produced ethanol. - An Alcohol Dehydrogenase Gene from Synechocystis sp. Confers Salt Tolerance in Transgenic Tobacco
Yi, Frontiers in plant science 2017 - “...are underlined. GenBank accessions for PCC 6906, PCC 6803, and horse liver ADHs are KY014075, WP_010874320, and NP_001075414.1, respectively. Click here for additional data file. Click here for additional data file. FIGURE S2 | Analysis of sysr1 -overexpressing transgenic N. benthamiana lines. (A) transformation of N....”
- Review of recent advances in improvement strategies for biofuels production from cyanobacteria
Mescouto, Heliyon 2024 - “...inserting the pyruvate decarboxylase (PDC) gene from Zymobacter palmae , in conjunction with the endogenous slr1192 alcohol dehydrogenase (adhA) gene expressed in Synechocystis sp. PCC6803, did not induce an increase in ethanol production compared to inserting the PDC from Zymomonas mobilis , which has traditionally been...”
- Sustainable production of photosynthetic isobutanol and 3-methyl-1-butanol in the cyanobacterium Synechocystis sp. PCC 6803
Xie, Biotechnology for biofuels and bioproducts 2023 - “...LeuCD, 3-isopropylmalate dehydratase; LeuB, 3-isopropylmalate dehydrogenase; Kivd S286T , -ketoisovalerate decarboxylase ( Lactococcus lactis ); Slr1192 OP , codon-optimized native alcohol dehydrogenase. Dotted lines indicate multiple reactions Different from heterotrophic microorganisms feeding on substrates generated from plant biomass, photosynthetic microorganisms, including cyanobacteria, are capable to use...”
- “...(see Additional file 1 : Table S2). The sequences of gene fragments kivd S286T , slr1192 OP , sll0065 , slr2088 , sll1363 , slr0452 , alsS , ilvC , ilvD , fbaA , tktA and pyk1 were codon-optimized and synthesized by GenScript. All gene sequences...”
- Rewiring carbon flow in Synechocystis PCC 6803 for a high rate of CO2-to-ethanol under an atmospheric environment
Gao, Frontiers in microbiology 2023 - “...( 2012 ) 2014 Synechocystis PCC6803 P petJ - pdc-adhII ( Z. mobilis ) at slr1192 432 18 24 Dienst et al. ( 2014 ) 2016 Synechocystis PCC6803 Excessive NADPH production by zwf over-expression 590 14 42 Choi and Park ( 2016 ) 2016 Synechocystis PCC6803...”
- Expressing 2-keto acid pathway enzymes significantly increases photosynthetic isobutanol production
Xie, Microbial cell factories 2022 - “...additional expression of acetolactate synthase (AlsS), acetohydroxy-acid isomeroreductase (IlvC), dihydroxy-acid dehydratase (IlvD), and alcohol dehydrogenase (Slr1192 OP ), the Synechocystis strain HX42, with a functional 2-keto acid pathway, showed enhanced isobutanol production reaching 98mgL 1 in short-term screening experiments. Through modulating kivd S286T copy numbers as...”
- “...); IlvD, dihydroxy-acid dehydratase ( E. coli ); Kivd, -ketoisovalerate decarboxylase ( Lactococcus lactis ); Slr1192 OP , codon optimized alcohol dehydrogenase ( Synechocystis ); PEPc, phosphoenolpyruvate carboxylase; Ddh, d -lactate dehydrogenase; GlgC: glucose-1-phosphate adenylyltransferase; GlgA, glycogen synthase; GlgB, 1,4--glucan branching enzyme; LeuA, 2-isopropylmalate synthase; LeuCD,...”
- Light-induced production of isobutanol and 3-methyl-1-butanol by metabolically engineered cyanobacteria
Kobayashi, Microbial cell factories 2022 - “...alcohol production: kdc , encoding keto-acid decarboxylase(KDC) derived from L. lactis [ 3 ], and slr1192 , encoding alcohol dehydrogenase (ADH) derived from PCC 6803 [ 29 ]. For isobutanol production in E. coli , we previously prepared a synthetic kdc gene with codons optimized for...”
- “...K. K., Tokyo, Japan) system from the subcloned vector using primers P01 and P02. The slr1192 gene was also amplified via PCR from the PCC 6803 genome using primers P03 and P04 and was inserted downstream of P cpcG2 on the pKT-GSS vector with a SD-like...”
- Synthetic biology promotes the capture of CO2 to produce fatty acid derivatives in microbial cell factories
Liu, Bioresources and bioprocessing 2022 - “...PDChimslr1192 pathway which consists of ketoacid decarboxylase ( PDChim ) and ethanol dehydrogenase II ( Slr1192 ) in engineering cyanobacteria. The results show that to further improve its ethanol synthesis ability, it is necessary to further improve its activity, increase its proportion and keep it at...”
- Rapidly Improving High Light and High Temperature Tolerances of Cyanobacterial Cell Factories Through the Convenient Introduction of an AtpA-C252F Mutation
Zhang, Frontiers in microbiology 2021 - “...containing the spectinomycin resistance gene, the PrbcL promoter sequence, the Pdc ZM gene, and the slr1192 gene was amplified from a previously constructed pZG25 plasmid ( Gao et al., 2012 ) and ligated with the backbone of another previously constructed plasmid pFL20n ( Duan et al.,...”
- “...mutation This study ZN44 Mutant strain of PCC 7942 harboring NS1:: P rbcL -pdc ZM -slr1192 , Sp r This study ZN45 Mutant strain derived from ZN44, carrying AtpA with the C252F point mutation This study Plasmids pSS3 Carrying the wild-type PCC 7942 atpA gene This...”
- Combinatorial use of environmental stresses and genetic engineering to increase ethanol titres in cyanobacteria
Andrews, Biotechnology for biofuels 2021 - “...cassette Genotype Ethanol rate (g/L/d) Comments Refs. Synechocystis strain PCC 6803 pdc Zm +adh Syn (slr1192) glgC + phaC + phaE 0.986 Dual copies; 2.96g/L in 3 d; highest OD 730 ~50; pnblA promoter [ 27 ] ~0.2 Dual copies; 5.5g/L in 26 d; highest OD...”
- “...30 d; psbA promoter [ 36 ] Synechococcus strain PCC 7002 pdc Zm +adh Syn (slr1192) glgA1 + glgA2 0.220 Dual copies; 2.2g/L in 10 d; highest OD 730 ~4; prbc promoter [ 37 ] - - 0.410 Patented, JCC1581_B isolate; 5.62g/L in 13.7 d; [...”
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CADH_MAIZE / O24562 Probable cinnamyl alcohol dehydrogenase; CAD; Brown-midrib 1 protein; EC 1.1.1.195 from Zea mays (Maize) (see paper)
46% identity, 94% coverage
- function: Involved in lignin biosynthesis. May catalyze the final step specific for the production of lignin monomers, like coniferyl alcohol, sinapyl alcohol and 4-coumaryl alcohol.
catalytic activity: (E)-cinnamyl alcohol + NADP(+) = (E)-cinnamaldehyde + NADPH + H(+) (RHEA:10392)
catalytic activity: (E)-coniferol + NADP(+) = (E)-coniferaldehyde + NADPH + H(+) (RHEA:22444)
catalytic activity: (E)-sinapyl alcohol + NADP(+) = (E)-sinapaldehyde + NADPH + H(+) (RHEA:45704)
catalytic activity: (E)-4-coumaroyl alcohol + NADP(+) = (E)-4-coumaraldehyde + NADPH + H(+) (RHEA:45724)
catalytic activity: (E)-caffeyl alcohol + NADP(+) = (E)-caffeyl aldehyde + NADPH + H(+) (RHEA:45728)
cofactor: Zn(2+) (Binds 2 Zn(2+) ions per subunit.)
subunit: Homodimer.
disruption phenotype: Reduced lignin content, and modified lignin of reddish-brown color. - Hypoxia-Responsive Class III Peroxidases in Maize Roots: Soluble and Membrane-Bound Isoenzymes
Hofmann, International journal of molecular sciences 2020 - “...whereas that of zmcad1 (B4FAJ0) was moderately upregulated. Expression levels of zmcad6 (B4FR97) and zmcad (O24562) decreased significantly, 2.5-fold and 2.9-fold, respectively. Most of the zmcad genes were downregulated. The expression level of cellulose synthase 5 ( zmcesa , A0A1D6L8J3) increased 2.8-fold, whereas two other zmcesa...”
- Spatial gradients in cell wall composition and transcriptional profiles along elongating maize internodes
Zhang, BMC plant biology 2014 - “...E-118 AtCCoAOMT1 Caffeoyl CoA 3-O-methyltransferase (Q6VWH0) 0.91 0.96 0.88 At4g34050 E-104 AtCCoAOMT1 Cinnamyl alcohol dehydrogenase (O24562) 0.90 0.94 0.87 At3g19450 E-177 AtCAD4 4-coumarate coenzyme A ligase (Q6Q297) 0.93 0.92 0.87 At3g21240 0 At4CL2 Peroxidase P7X (Q9ZTS7) 0.72 0.91 0.76 At5g05340 E-82 - Carboxylate oxidase (Q75IP9) 0.74...”
B6U7D8 cinnamyl-alcohol dehydrogenase (EC 1.1.1.195) from Zea mays (see paper)
46% identity, 94% coverage
WS_STRNX / P0DO83 Wieland-Gumlich aldehyde synthase; SnvWS; EC 1.5.1.- from Strychnos nux-vomica (Poison nut) (Strychnine tree) (see paper)
41% identity, 93% coverage
- function: Alcohol dehydrogenase involved in the biosynthesis of curare monoterpene indole alkaloids (MIAs), natural products such as strychnine, a neurotoxic compound used as a pesticide to control rodents, and its pharmacologically active derivatives, including brucine, used to regulate blood pressure (PubMed:35794473). Curare alkaloids act as animal glycine receptor antagonists (PubMed:35794473). Catalyzes the conversion of norfluorocurarine to desoxy Wieland-Gumlich aldehyde, and of 18-OH norfluorocurarine to Wieland-Gumlich aldehyde (PubMed:35794473).
catalytic activity: (19E)-cur-19-en-17-al + NADP(+) = norfluorocurarine + NADPH + H(+) (RHEA:80903)
catalytic activity: 17,18-epoxy-17-hydroxycur-19-ene + NADP(+) = 18- hydroxynorfluorocurarine + NADPH + H(+) (RHEA:80911)
cofactor: Zn(2+) (Binds 2 Zn(2+) ions per subunit.)
subunit: Homodimer.
CAD5 / O49482 cinnamyl alcohol dehydrogenase 5 (EC 1.1.1.195) from Arabidopsis thaliana (see 3 papers)
CADH5_ARATH / O49482 Cinnamyl alcohol dehydrogenase 5; AtCAD5; Cinnamyl alcohol dehydrogenase D; EC 1.1.1.195 from Arabidopsis thaliana (Mouse-ear cress) (see 5 papers)
O49482 cinnamyl-alcohol dehydrogenase (EC 1.1.1.195) from Arabidopsis thaliana (see 2 papers)
AT4G34230 ATCAD5 (CINNAMYL ALCOHOL DEHYDROGENASE 5); cinnamyl-alcohol dehydrogenase from Arabidopsis thaliana
NP_195149 cinnamyl alcohol dehydrogenase 5 from Arabidopsis thaliana
44% identity, 96% coverage
- function: Involved in lignin biosynthesis in the floral stem. Catalyzes the final step specific for the production of lignin monomers. Catalyzes the NADPH-dependent reduction of coniferaldehyde, 5- hydroxyconiferaldehyde, sinapaldehyde, 4-coumaraldehyde and caffeyl aldehyde to their respective alcohols.
catalytic activity: (E)-cinnamyl alcohol + NADP(+) = (E)-cinnamaldehyde + NADPH + H(+) (RHEA:10392)
catalytic activity: (E)-coniferol + NADP(+) = (E)-coniferaldehyde + NADPH + H(+) (RHEA:22444)
catalytic activity: (E)-sinapyl alcohol + NADP(+) = (E)-sinapaldehyde + NADPH + H(+) (RHEA:45704)
catalytic activity: (E)-4-coumaroyl alcohol + NADP(+) = (E)-4-coumaraldehyde + NADPH + H(+) (RHEA:45724)
catalytic activity: (E)-caffeyl alcohol + NADP(+) = (E)-caffeyl aldehyde + NADPH + H(+) (RHEA:45728)
cofactor: Zn(2+) (Binds 2 Zn(2+) ions per subunit.)
subunit: Homodimer.
disruption phenotype: Reduced lignin content and rigidity of the floral stems. - Genome-wide identification of the CAD gene family and functional analysis of putative bona fide CAD genes in tobacco (Nicotiana tabacum L.)
Wu, Frontiers in plant science 2024 - “...of NtCADs and bona fide Arabidopsis CADs. The bona fide AtCADs AtCAD4 (At3g19450) and AtCAD5 (At4g34230) were used as reference sequences. Zn-binding motifs are highlighted in red boxes, and the NADP(H)-binding motif is also indicated. The red and purple arrows denote the presence of conserved amino...”
- TRUEE; a bioinformatic pipeline to define the functional microRNA targetome of Arabidopsis
Wong, The Plant journal : for cell and molecular biology 2022 - “...2 X 2 0.148 miR408 AT2G47900 TLP3, TUBBY LIKE PROTEIN 3 X 2 0.131 miR408 AT4G34230 CAD5, Cinnamyl Alcohol Dehydrogenase 5 X 2 0.131 Library % Cutoff threshold meet for each HE target is indicated by X'. Genes in bold type indicate HE targets that were...”
- “...2 0.333 miR398 AT4G26230 Ribosomal protein L31e family protein X X X 2 0.333 miR408 AT4G34230 CINNAMYL ALCOHOL DEHYDROGENASE 5 X X X 2 0.333 miR857 AT5G36880 ACS, acetylCoA synthetase X X X 2 0.333 miR159 AT2G21600 endoplasmatic reticulum retrieval protein 1B X 2 0.167 miR159...”
- Phytochromes and Their Role in Diurnal Variations of ROS Metabolism and Plant Proteome
Luklová, International journal of molecular sciences 2022 - “...A lower nightday ratio was found for 37 lhy-specific regulations, including Cinnamyl alcohol dehydrogenase CADH5 (AT4G34230, which is involved in lignin biosynthesis, [ 58 ]); Ferredoxin-plastoquinone reductase PGL1A (AT4G22890,which is involved in cyclic electron flow); and GDSL esterase/lipase ESM1 (AT3G14210, which mediates indol-3-acetonitrile production, [ 59...”
- CORK1, A LRR-Malectin Receptor Kinase, Is Required for Cellooligomer-Induced Responses in Arabidopsis thaliana
Tseng, Cells 2022 - “...production: caffeoyl-CoA 3-O-methyltransferase (~13 fold; CCoAOMT, AT1G67980 ), cinnamyl alcohol dehydrogenase 5 (~3 fold; CAD5, AT4G34230 ) and peroxidase 4 (~5 fold; class III peroxidase PER4, AT1G14540) [ 51 , 52 ]. PEN2 and PMR4/GSL5, encoding a myrosinase and a callose synthase, respectively, were only slightly...”
- “...1.75 10 20 AT1G51680 4CL1 2.08 7.53 10 26 AT1G67980 CCOAOMT 3.67 6.47 10 5 AT4G34230 CAD5 1.60 6.77 10 10 AT1G14540 PER4 2.44 1.93 10 22 Leaf senescence AT5G24110 WRKY30 3.29 7.20 10 16 ABA signaling AT1G80840 WRKY40 2.75 6.59 10 9 Plant-pathogen interaction AT2G19990...”
- Genome-wide analysis of the CAD gene family reveals two bona fide CAD genes in oil palm
Yusuf, 3 Biotech 2022 - “...Bradi3g06480 (Phytozome), AtCAD4: At3g19450 (Phytozome), AtCAD5: At4g34230 (Phytozome), EgCAD1: XP_010932224 and EgCAD2: XP_010943210. The 3D structures of bona...”
- Proteomic and metabolic disturbances in lignin-modified Brachypodium distachyon
Barros, The Plant cell 2022 - “...) At3g19450 Bd CAD1 Bradi3g06480 82 I1HY48 N High 8.01.0 At CAD5 ( CAD-D ) At4g34230 Bd CAD2 Bradi4g29780 64 I1IPY8 N Low 2.30.3 Step 12: PMT: Bd PMT1 Bradi2g36910 100 I1HM65 N High 1.60.2 Step 13: Monolignol-oxidizing LAC: At LAC7 At3g09220 Bd LAC7 Bradi2g55050 61...”
- CAD Genes: Genome-Wide Identification, Evolution, and Their Contribution to Lignin Biosynthesis in Pear (Pyrus bretschneideri)
Qi, Plants (Basel, Switzerland) 2021 - “...http://www.rosaceae.org/ , 25 September 2019). Nine CAD protein sequences of Arabidopsis (AT1G72680, AT2G21730, AT2G21890, AT3G19450, AT4G34230, AT4G37970, AT4G37980, AT4G37990, and AT4G39330) were downloaded from The Arabidopsis Information Resource ( http://www.arabidopsis.org/ , 25 September 2019) and used as queries to perform a BLAST search against the four...”
- Comparative Analyses of Phyllosphere Bacterial Communities and Metabolomes in Newly Developed Needles of Cunninghamia lanceolata (Lamb.) Hook. at Four Stages of Stand Growth
Sun, Frontiers in plant science 2021 - “...(at3g21230 and at1g20500), elicitor-activated gene 3-2 (ELI3-2) (at4g37990 and at4g37980), and cinnamyl alcohol dehydrogenase (at4g37970, at4g34230, at4g34230, and at2g21730). In SM35, more than half of DEGs were down-regulated compared with SM15 ( Supplementary Table 3 ). Discussion Analysis of Chinese Fir Phyllosphere Bacterial Communities at Four...”
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- Physcomitrium patens CAD1 has distinct roles in growth and resistance to biotic stress
Jiang, BMC plant biology 2022 - “...the tree are: Arabidopsis thaliana AtCAD1 (NP_195643); AtCAD2 (NP_195510); AtCAD3(CAA48027); AtCAD4 (NP_195512); AtCAD5 (NP_188576); AtCAD6 (NP_195149); AtCAD7 (NP_179765); AtCAD8 (NP_179780); AtCAD9 (NP_177412); Populus tremuloides PtCAD1 (AAF43140); PtCAD2 (AAK58693);PtCAD3 (AAK58693); PtCAD4 (AAK58693); PtCAD5 (AAK58693); PtCAD6 (AAK58693); PtCAD7 (AAK58693); PtCAD8 (AAK58693) PtCAD9 (AAK58693); Oryza sativa OsCAD1 (DAA02237); OsCAD2...”
- Manipulation of Guaiacyl and Syringyl Monomer Biosynthesis in an Arabidopsis Cinnamyl Alcohol Dehydrogenase Mutant Results in Atypical Lignin Biosynthesis and Modified Cell Wall Structure.
Anderson, The Plant cell 2015 - GeneRIF: Data show that disruption of the genes encoding both cinnamyl alcohol dehydrogenases CADC (At3g19450) and CADD (At4g34230) results in the atypical incorporation of hydroxycinnamaldehydes into lignin.
- The simultaneous repression of CCR and CAD, two enzymes of the lignin biosynthetic pathway, results in sterility and dwarfism in Arabidopsis thaliana.
Thévenin, Molecular plant 2011 (PubMed)- GeneRIF: Repressing both the CAD and the CCR activities results in sterility and dwarfism.
- Root and vascular tissue-specific expression of glycine-rich protein AtGRP9 and its interaction with AtCAD5, a cinnamyl alcohol dehydrogenase, in Arabidopsis thaliana.
Chen, Journal of plant research 2007 (PubMed)- GeneRIF: These results suggest that AtGRP9 may be involved in lignin synthesis in response to salt stress as a result of its interaction with AtCAD5 in A. thaliana.
- Crystal structures and catalytic mechanism of the Arabidopsis cinnamyl alcohol dehydrogenases AtCAD5 and AtCAD4.
Youn, Organic & biomolecular chemistry 2006 (PubMed)- GeneRIF: determined the crystal structures of AtCAD5 in the apo-form and as a binary complex with NADP+, respectively, and modeled that of AtCAD4. The substrate-binding pockets of both AtCAD5 and AtCAD4 were also examined.
- Genome-wide identification of the CAD gene family and functional analysis of putative bona fide CAD genes in tobacco (Nicotiana tabacum L.)
Wu, Frontiers in plant science 2024 - “...tobacco (Ntab, Ntom, and Nsyl); Arabidopsis thaliana , AtCAD19 (accession number: Q9CAI3, Q9SJ25, Q9SJ10, P48523, O49482, O65621, Q02971, Q02972, P42734); Oryza sativa , OsCAD19 (Q8H859, Q6ZHS4, Q337Y2, Q2R114, Q0J6T3, Q7XWU3, Q0JA75, Q6ERX1, Q10PS6); Brachypodium distachyon , BdCAD3 (AFK80371), BdCAD5 (AFK80372); Triticum aestivum , TaCAD1 (GU563724); Elaeis...”
2cf5A / O49482 Crystal structures of the arabidopsis cinnamyl alcohol dehydrogenases, atcad5 (see paper)
44% identity, 97% coverage
A3A3Y3 cinnamyl-alcohol dehydrogenase from Oryza sativa subsp. japonica
45% identity, 96% coverage
DPAS / A0A1B1FHP3 dehydroprecondylocarpine acetate synthase from Catharanthus roseus (see 2 papers)
DPAS_CATRO / A0A1B1FHP3 Dehydroprecondylocarpine acetate synthase; EC 1.3.1.128 from Catharanthus roseus (Madagascar periwinkle) (Vinca rosea) (see paper)
43% identity, 95% coverage
- function: Component of the seco-iridoid and derivatives monoterpenoid indole alkaloids (MIAs, e.g. vinblastine, catharanthine, tabersonine, vincadifformine, vindoline, vincristine, quinine and strychnine) biosynthesis pathway. Converts precondylocarpine acetate to dihydroprecondylocarpine acetate.
catalytic activity: dihydroprecondylocarpine acetate + NADP(+) = precondylocarpine acetate + NADPH + H(+) (RHEA:58576)
cofactor: Zn(2+) (Binds 2 Zn(2+) ions per subunit.)
subunit: Homodimer. Interaction with catharanthine synthase (CS) and tabersonine synthase (TS).
disruption phenotype: Strong accumulation of precondylocarpine acetate.
LOC103840386 cinnamyl alcohol dehydrogenase 5 from Brassica rapa
44% identity, 95% coverage
- Transcriptomic Insights Into Root Development and Overwintering Transcriptional Memory of Brassica rapa L. Grown in the Field
Liu, Frontiers in plant science 2022 - “...( Supplementary Table 7 ), four were associated with cinnamyl alcohol dehydrogenase (CAD: LOC103828799, LOC103835065, LOC103840386 , and LOC103867418 ) and peroxidase (PER/LAC: LOC103837896, LOC103869716, LOC103846031 , and LOC103847421 ). In Longyou-7, more genes related to peroxidase (PER/LAC) were downregulated; however, in Tianyou-4 and Lenox, the...”
A0A0P0VFU1 cinnamyl-alcohol dehydrogenase (EC 1.1.1.195) from Oryza sativa Japonica Group (see paper)
48% identity, 88% coverage
ACIAD3612 putative alcohol dehydrogenase from Acinetobacter sp. ADP1
36% identity, 96% coverage
- Photosynthetic Conversion of Carbon Dioxide to Oleochemicals by Cyanobacteria: Recent Advances and Future Perspectives
Wang, Frontiers in microbiology 2020 - “...50.0 0.06 Lee et al., 2017 26 Syn7942 Wax AtfA, Aar, Slr1192 from Syn6803 or ACIAD3612 from A. baylyi ADP1 1% CO 2 , 50 E/m 2 /s ND ND ND Kaiser et al., 2013 a The number was converted using a calibration between DCW and...”
- “...Aar as well as a long-chain alcohol dehydrogenase from Syn6803 (Adh, Slr1192) or A. bayli (ACIAD3612) ( Kaiser et al., 2013 ). Given the fact that FFA accumulates in the wax-producing strain as the byproduct ( Kaiser et al., 2013 ), the endogenous aldE gene might...”
- Fatty aldehydes in cyanobacteria are a metabolically flexible precursor for a diversity of biofuel products
Kaiser, PloS one 2013 - “...baylyii (DGAT); DGAT and Aar; DGAT, Aar and slr1192 (triple 1); or DGAT, Aar and ACIAD3612 (triple 2) were analyzed 24 hours post-induction by TLC using nonpolar solvents to resolve WE and TAG ( A ) or polar solvents to resolve fatty acids ( B )....”
- “...This resulted in wax ester production ( Fig. 5A ). A related alcohol dehydrogenase ( ACIAD3612 from A. bayli ; 48% identity to slr1192) also produced wax esters when coexpressed with Aar and aDGAT ( Fig. 5 ; triple 2). These strains also produced free fatty...”
- Purification and characterization of an NAD+-dependent XylB-like aryl alcohol dehydrogenase identified in Acinetobacter baylyi ADP1
Uthoff, Applied and environmental microbiology 2012 - “...(31) suggested the NADPH-dependent alcohol dehydrogenase AlrA (ACIAD3612) to be responsible for this reaction in A. baylyi, and aldehydereducing enzymes have...”
- “...et al. (25). For disruption of areB (ACIAD1429), alrA (ACIAD3612), and the gene with annotation number ACIAD1578 (referred to here as xylBADP1), the genes were...”
PputUW4_03046 NAD(P)-dependent alcohol dehydrogenase from Pseudomonas sp. UW4
39% identity, 96% coverage
- The complete genome sequence of the plant growth-promoting bacterium Pseudomonas sp. UW4
Duan, PloS one 2013 - “...in acetoin production were identified, including acetolactate synthase (PputUW4_04612 and PputUW4_04613) and zinc-containing alcohol dehydrogenase (PputUW4_03046). However, acetoin reductase that is responsible for the conversion of acetoin to 2,3-butanediol is absent from the UW4 genome. When the genomes of the other Pseudomonas were examined for acetoin...”
KP1_0570 putative alcohol dehydrogenase from Klebsiella pneumoniae NTUH-K2044
38% identity, 97% coverage
VK055_2769 NAD(P)-dependent alcohol dehydrogenase from Klebsiella pneumoniae subsp. pneumoniae
38% identity, 96% coverage
- A systematic analysis of hypermucoviscosity and capsule reveals distinct and overlapping genes that impact Klebsiella pneumoniae fitness
Mike, PLoS pathogens 2021 - “...sdhB , sdhA , sdhC ), electron transport ( nuoE ), fermentation ( acoB , VK055_2769 , VK055_3280) , C4-dicarboxylate metabolism ( VK055_0953 ), and sugar metabolism ( VK055_0993 , VK055_2839 , pgi ), along with many of the aforementioned genes involved in the transport of...”
A6THK0 Alcohol dehydrogenase from Klebsiella pneumoniae subsp. pneumoniae (strain ATCC 700721 / MGH 78578)
38% identity, 96% coverage
FOXG_09028 alcohol dehydrogenase (NADP+) from Fusarium oxysporum f. sp. lycopersici 4287
37% identity, 94% coverage
- Genome wide transcriptome profiling of Fusarium oxysporum f sp. ciceris conidial germination reveals new insights into infection-related genes
Sharma, Scientific reports 2016 - “...to explore their function during establishment of Foc disease. Transcripts involved in alcohol dehydrogenase activity (FOXG_09028) have also shown a marked increase in their expression. There was an up-regulation of gamma-glutamyl transferase and gamma-glutamyl transpeptidase, involved in gamma-aminobutyric acid catabolic process that has been reported to...”
- “...FOXG_09820 Phosphorylcholine phosphatase 0.89 4.7 5.06 13.92 FOXG_15398 Multidrug resistant protein 1.05 18.85 8.25 8.92 FOXG_09028 NADP-dependent alcohol dehydrogenase VI 0.32 1.77 2.53 114.35 FOXG_09770 Transferase 0.09 0.77 21.01 90.05 FOXG_10443 Chitin synthase 2 0.01 0.29 0.99 2.47 FOXG_01655 Kinesin family protein 0.07 0.62 1.39 2.91...”
W6CX26 alcohol dehydrogenase (EC 1.1.1.1); aryl-alcohol dehydrogenase (EC 1.1.1.90); aryl-alcohol dehydrogenase (NADP+) (EC 1.1.1.91) from Yokenella sp. (see paper)
39% identity, 96% coverage
7bu2B / P27250 Structure of alcohol dehydrogenase yjgb from escherichia coli (see paper)
38% identity, 96% coverage
Ahr / b4269 NADPH-dependent aldehyde reductase Ahr (EC 1.1.1.2) from Escherichia coli K-12 substr. MG1655 (see 3 papers)
ahr / P27250 NADPH-dependent aldehyde reductase Ahr (EC 1.1.1.2) from Escherichia coli (strain K12) (see 11 papers)
AHR_ECOLI / P27250 Aldehyde reductase Ahr; Zinc-dependent alcohol dehydrogenase Ahr; EC 1.1.1.2 from Escherichia coli (strain K12) (see 3 papers)
P27250 geraniol dehydrogenase (NADP+) (EC 1.1.1.183) from Escherichia coli (see paper)
NP_418690 NADPH-dependent aldehyde reductase Ahr from Escherichia coli str. K-12 substr. MG1655
b4269 putative oxidoreductase from Escherichia coli str. K-12 substr. MG1655
38% identity, 96% coverage
- function: Catalyzes the reduction of a wide range of aldehydes including aliphatic fatty aldehydes (C4-C16), into their corresponding alcohols. Has a strong preference for NADPH over NADH as the electron donor. Cannot use glyceraldehyde or a ketone as substrate. Is a relevant source of NADPH-dependent aldehyde reductase activity in E.coli. The in vivo functions of Ahr has yet to be determined.
catalytic activity: a primary alcohol + NADP(+) = an aldehyde + NADPH + H(+) (RHEA:15937)
cofactor: Zn(2+) (Binds 2 Zn(2+) ions per subunit.) - Structural Basis for Broad Substrate Selectivity of Alcohol Dehydrogenase YjgB from Escherichia coli.
Nguyen, Molecules (Basel, Switzerland) 2020 - GeneRIF: Structural Basis for Broad Substrate Selectivity of Alcohol Dehydrogenase YjgB from Escherichia coli.
- Sex and gender bias in the experimental neurosciences: the case of the maternal immune activation model
Coiro, Translational psychiatry 2019 - “...appreciation for women in science. https://doi.org/10.13039/501100002428 Austrian Science Fund (Fonds zur Frderung der Wissenschaftlichen Forschung) P27250 Pollak Daniela D. issue-copyright-statement The Author(s) 2019 Introduction Despite decade-long efforts, including officially declared intentions and a variety of initiatives for enhancing gender equality, gender biases in scientific environments still...”
- Proteomic response analysis of a threonine-overproducing mutant of Escherichia coli
Kim, The Biochemical journal 2004 - “...43.21 48.06 50.73 49.91 39.36 35.24 29.99 P04422 P07913 P27250 P06999 P05640 P06721 P00891 P14178 P30127 P25437 P30867 P06994 58.8 76.9 57.1 66.7 64.3 78.9 76.9...”
- Identification of RpoS (sigma(S))-regulated genes in Salmonella enterica serovar typhimurium
Ibanez-Ruiz, Journal of bacteriology 2000 - “...(YehY), P37663 (YhjY), P07003 (PoxB), P76114 (YncC), P27250 (YjgB), P75694 (YahO), P39169 (YgaU), P31677 (OtsA), P77391 (YeaG), P21179 (KatE), P21362 (YciF),...”
- Silencing of NADPH-dependent oxidoreductase genes (yqhD and dkgA) in furfural-resistant ethanologenic Escherichia coli
Miller, Applied and environmental microbiology 2009 - “...no. Fold increase or decrease b0419 b1670 b1673 b2774 b1650 b4269 b1668 b1674 1.9 1.8 2.0 2.1 4.5 2.0 1.9 1.9 2-Fold lowerb yqhD dkgA yjjN yqfA b3011 b3012...”
- Genome-wide analysis of the general stress response network in Escherichia coli: sigmaS-dependent genes, promoters, and sigma factor selectivity
Weber, Journal of bacteriology 2005 - “...yhfW yjcS yjgB yncG b0453 b0897 b2301 b3073 b3380 b4083 b4269 b1454 ysgA b3830 Regulation (11) bolA b0435 chaB csiR b1217 b2664 gadW b3515 gadX b3516 gem pdhR...”
- Adaptation to famine: a family of stationary-phase genes revealed by microarray analysis
Tani, Proceedings of the National Academy of Sciences of the United States of America 2002 - “...yeaG ygaU yhiV yjgB yncC yohF b1259 b1440 b1783 b2665 b3514 b4269 b1450 b2137 4.6 2.3 7.0 6.4 3.2 3.0 2.7 3.1 Genes indicated in bold are annotated in GenBank...”
B21_04099 NADPH-dependent aldehyde reductase Ahr from Escherichia coli BL21(DE3)
38% identity, 96% coverage
- Modular assembly of an artificially concise biocatalytic cascade for the manufacture of phenethylisoquinoline alkaloids
Gao, Nature communications 2024 - “..., accession number: B21_01738 ; yahK , accession number: B21_00284 ; yjgB , accession number: B21_04099 and yqhC , accession number: B21_02833 ) were obtained from online software ( https://www.atum.bio/eCommerce/cas9/input ) and ligated to the plasmid pTargetF (Addgene), giving the modified pTargetF. The upstream and downstream...”
- Structural Basis for Broad Substrate Selectivity of Alcohol Dehydrogenase YjgB from Escherichia coli
Nguyen, Molecules (Basel, Switzerland) 2020 - “...Sb CAD, Pt CAD, and Nerol. Sequences of Ec YjgB, Escherichia coli BL21 (DE3) YjgB (B21_04099); Hp CAD, Helicobacter pylori cinnamyl alcohol dehydrogenase (PDB code: 3TWO); Ec YakK, Escherichia coli BL21 (DE3) YahK (PDB code: 1UUF); Sb CAD, Sorghum bicolor cinnamyl alcohol dehydrogenase (SbCAD) (PDB code:...”
STM4486 putative alcohol dehydrogenase from Salmonella typhimurium LT2
SL1344_4416 NAD(P)-dependent alcohol dehydrogenase from Salmonella enterica subsp. enterica serovar Typhimurium str. SL1344
39% identity, 97% coverage
- Salmonella serovar identification using PCR-based detection of gene presence and absence
Arrach, Journal of clinical microbiology 2008 - “...STM4373, STM4413, STM4420, STM4426, STM4445, STM4484, STM4486, STM4493, STM4499, STM4524, STM4527, STM4537, STM4573, STM4574, STM4589, STM4590, PSLT006,...”
- Structure-based analyses of Salmonella RcsB variants unravel new features of the Rcs regulon
Huesa, Nucleic acids research 2021 - “...gene intra-CDS + 1807 TGGGATTCGCCTCA 2.26 2181905 SL1344_2078 wcaK downstream-gene intra-CDS 251 TGAGAATATACTGA 2.91 4750668 SL1344_4416 yjgB gene intra-CDS 703 TGAGATCGAACTGA 3.23 2198160 SL1344_2093 wzc gene intra-CDS 615 TGAGAATTTACTCA 4.43 4114157 SL1344_3849 rbsA gene intra-CDS + 761 TGAGATTCGCCTCA 2.23 4271020 SL1344_3987 antisense internalTSS + 4271128 108...”
LOC107772996 8-hydroxygeraniol dehydrogenase from Nicotiana tabacum
49% identity, 74% coverage
c5370 Hypothetical zinc-type alcohol dehydrogenase-like protein yjgB from Escherichia coli CFT073
38% identity, 96% coverage
L2164_00385 NAD(P)-dependent alcohol dehydrogenase from Pectobacterium brasiliense
37% identity, 97% coverage
6c49A / A0A1E3MC83 Crystal structure of alcohol dehydrogenase from acinetobacter baumannii
36% identity, 96% coverage
PAS_chr4_0576 NADPH-dependent medium chain alcohol dehydrogenase with broad substrate specificity from Komagataella phaffii GS115
38% identity, 95% coverage
CTRG_02797 conserved hypothetical protein from Candida tropicalis MYA-3404
36% identity, 89% coverage
AO090010000668 No description from Aspergillus oryzae RIB40
37% identity, 94% coverage
alrA / BAB12270.1 NADP-dependent alcohol dehydrogenase from Acinetobacter sp. M-1 (see paper)
35% identity, 97% coverage
PITG_00972 mannitol dehydrogenase, putative from Phytophthora infestans T30-4
37% identity, 97% coverage
- Bioinformatic inference of specific and general transcription factor binding sites in the plant pathogen Phytophthora infestans
Seidl, PloS one 2012 - “...Motif-1 avr2 family PITG_08278 119 ctcag TACATGTAA ccccg 0.98 0.96 0.42 0.39 Motif-1 Mannitol dehydrogenase PITG_00972 352 acatg TACATGTAt taat 2.06 2.67 0.85 0.11 Motif-1 Polygalacturonase PITG_21247 108 gatgg TACATGTAC acggg 0.67 0.01 0.21 0.13 Motif-3 Pred. RXLR effector PITG_09218 108 ttgaa TGCAAATACTAAGTCA aactg 2.48 1.89...”
- “...( Figure 4 & Table 1 & Table S3 ). The differentially expressed mannitol-dehydrogenase gene (PITG_00972) is an example of an oxidoreductase within the enriched class of catalytic enzymes that is up-regulated early during infection ( Table 1 ). Mannitol can suppress of ROS-related plant responses...”
BC1G_10664 hypothetical protein from Botrytis cinerea B05.10
35% identity, 93% coverage
CNAG_01955 alcohol dehydrogenase from Cryptococcus neoformans var. grubii H99
37% identity, 93% coverage
7c2oA / M4VRJ6 Crystal structure of the r-specific carbonyl reductase from candida parapsilosis atcc 7330 without dtt
38% identity, 96% coverage
- Ligands: zinc ion; nadph dihydro-nicotinamide-adenine-dinucleotide phosphate (7c2oA)
M4VRJ6 carbonyl reductase (NADPH) (EC 1.1.1.184) from Candida parapsilosis (see paper)
38% identity, 95% coverage
HMPREF1120_07268 alcohol dehydrogenase (NADP+) from Exophiala dermatitidis NIH/UT8656
37% identity, 86% coverage
- Transcriptomic and genomic changes associated with radioadaptation in Exophiala dermatitidis
Malo, Computational and structural biotechnology journal 2021 - “...HMPREF1120_06649 Arginase pks A12 6 48,768 Frameshift HMPREF1120_06854 Phytanoyl-CoA hydroxylase pks A9 6 1,198,245 Missense HMPREF1120_07268 Alcohol dehydrogenase (NADP+) pks A12 6 1,666,136 Disruptive inframe deletion HMPREF1120_07440 MFS transporter, SP family, sugar:H+symporter pks A12 6 1,971,753 Intergenic HMPREF1120_07545 Redox-sensitive bicupin; pirin superfamily pks A9 6 1,971,778...”
CNBG_2992 alcohol dehydrogenase from Cryptococcus deuterogattii R265
37% identity, 93% coverage
- Fungal zinc metabolism and its connections to virulence
Staats, Frontiers in cellular and infection microbiology 2013 - “...ZIP2 (CNAG_2209) 6.96 Zinc conservation XYL2 1.32 BZD99 0.96 CNBG_3878 2.73 ADH7 0.76 AHD6 0.41 CNBG_2992 0.81 ADH1 1.56 ADH4 1.19 CNBG_0427 2.21 a Log 2 Fold Change values retrieved from microarray expression data of WT and zap1 S. cerevisiae cells exposed to low zinc concentrations...”
- Zap1 regulates zinc homeostasis and modulates virulence in Cryptococcus gattii
Schneider, PloS one 2012 - “...hypothetical protein Putative GTPase activating protein for Arf 2.00 CNBG_1321 cytoplasm protein Zinc-binding dehydrogenase 0.62 CNBG_2992 alcohol dehydrogenase Alcohol dehydrogenase GroES-like domain 0.81 CNBG_3576 quinone oxidoreductase Alcohol dehydrogenase GroES-like domain 2.00 CNBG_3878 zinc-binding dehydrogenase Alcohol dehydrogenase GroES-like domain 2.73 CNBG_3919 xylitol dehydrogenase Alcohol dehydrogenase GroES-like domain...”
AO090005001358 No description from Aspergillus oryzae RIB40
38% identity, 94% coverage
An16g02510 uncharacterized protein from Aspergillus niger
38% identity, 94% coverage
- Engineering cofactor metabolism for improved protein and glucoamylase production in Aspergillus niger
Sui, Microbial cell factories 2020 - “...two cytosolic NADP-dependent enzymes (NADP-ICDH and NADP-ME) and three uncharacterized open reading frames (An12g04590, An14g00430, An16g02510). An12g04590, An14g00430 show high homology to NADP+oxidoreductases, and An16g02510 displays homology to alcohol dehydrogenases. In order to evaluate whether the model prediction is strain-dependent, we individually overexpressed all seven candidate...”
- “...NADP+oxidoreductase 3HBCoA[m]+NADP [m]<=>AACCoA[m]+NADPH [m]+H[m] An14g00430 R125 dihydrofolate:NADP+oxidoreductase NADP [m]+DHF[m]<=>NADPH [m]+FOLATE[m] An12g04590 R190 Alcohol dehydrogenase ETH+NADP<=>ACAL+NADPH+H An16g02510 [m] reactions in the mitochondrion; Rn, reaction. All reactions listed here were predicted in Lu et al. [ 31 ] Fig. 1 Pathway map highlighting all seven genes modified during...”
K9FYG6 Zinc-binding alcohol dehydrogenase, putative from Penicillium digitatum (strain Pd1 / CECT 20795)
37% identity, 94% coverage
- Deciphering Molecular Determinants Underlying Penicillium digitatum's Response to Biological and Chemical Antifungal Agents by Tandem Mass Tag (TMT)-Based High-Resolution LC-MS/MS
Citores, International journal of molecular sciences 2022 - “...following -sarcin and BE27 treatments such as Alcohol dehydrogenase-1 (AC: K9H784), Zinc-binding alcohol dehydrogenase (AC: K9FYG6) and Mannitol-1-phosphate dehydrogenase (AC: K9FJ71). By contrast, the enzyme Pyruvate decarboxylase that catalyses the formation of acetaldehyde on the pathway of ethanol synthesis was upregulated following both protein toxins and...”
- “...transporter (AC: K9H0P1). Another transporter involved in zinc homeostasis (i.e., the ZIP Zinc transporter, AC: K9FYG6) was only downregulated upon BE27 treatment as well as the Antifungal protein AFP (AC: K9FGI7), a small cysteine-rich protein endowed with a well-known specific antifungal activity. 3. Discussion Over the...”
Afu8g02430 zinc-binding alcohol dehydrogenase, putative from Aspergillus fumigatus Af293
37% identity, 94% coverage
- A heterologous expression platform in Aspergillus nidulans for the elucidation of cryptic secondary metabolism biosynthetic gene clusters: discovery of the Aspergillus fumigatus sartorypyrone biosynthetic pathway
Lin, Chemical science 2023 - “...a geranylgeranyl pyrophosphate synthase (GGPPS) gene (Afu8g02400), a hypothetical protein (Afu8g02420), and an alcohol dehydrogenase (Afu8g02430). 42 A C-4 methyl sterol oxidase (Afu8g02440) is adjacent. In all, the putative BGC is greater than 24 kbp in length. Synteny analysis in FungiDB reveals that the genes within...”
- “...Geranylgeranyl pyrophosphate synthase Afu8g02410 ( spyF ) sre1 83/76 cle5 68/57 Prenyltransferase Afu8g02420 Hypothetical protein Afu8g02430 Alcohol dehydrogenase Afu8g02440 C-4 methyl sterol oxidase No homolog cle2 P450 monooxygenase No homolog cle4 P450 monooxygenase Heterologous expression strategy of the Afu8g02350 BGC in A. nidulans Our heterologous expression...”
- Transcript levels of the Aspergillus fumigatus Cdc42 module, polarisome, and septin genes show little change from dormancy to polarity establishment
Oda, Medical mycology 2017 - “...Afu4g11250 Afu5g10890 Afu4g03360 Afu6g00510 Afu4g05900 Afu8g02430 Afu3g11430 Afu2g09060 Laminin-binding protein with extracellular thaumatin domain GPI anchored...”
- Regulation of Secondary Metabolism by the Velvet Complex Is Temperature-Responsive in Aspergillus
Lind, G3 (Bethesda, Md.) 2016 - “...known Afu8g02350 , Afu8g02360 , Afu8g02380 , Afu8g02390 , Afu8g02400 , Afu8g02410 , Afu8g02420 , Afu8g02430 Inglis et al. (2013) Temperature-shift experiments Conidia from WT strains were inoculated in CzapekDox (10 7 spores/ml) and grown as liquid shake cultures in the dark at 30. After 24...”
- Comprehensive annotation of secondary metabolite biosynthetic genes and gene clusters of Aspergillus nidulans, A. fumigatus, A. niger and A. oryzae
Inglis, BMC microbiology 2013 - “...ECS, IGD ECS, IGD This study Afu8g02350 cluster Afu8g02350 Afu8g02460 - Afu8g02350 Afu8g02490 - Afu8g02280 Afu8g02430 - Afu8g02350 ECS, IGD ECS, IGD This study No PKS or NRPS backbone 1 n/a - Afu4g11170 - Afu4g11300 - n/a n/a No PKS or NRPS backbone 2 n/a -...”
- Exploring the bZIP transcription factor regulatory network in Neurospora crassa
Tian, Microbiology (Reading, England) 2011 - “...Afu4g14530 Glutathione S -transferase NCU07452.2 OYE2 SPBC23G7.10c orf19.3131 Afu5g01450 Flavin oxidoreductase NCU08402.2 YCR105W SPCC13B11.01 orf19.5517 Afu8g02430 Alcohol dehydrogenase NCU09285.2 ADH5 SPBC1773.06c orf19.5113 Afu4g08240 Alcohol dehydrogenase NCU09534.2 Yir037w SPBC32F12.03c orf19.86 Afu3g12270 Peroxiredoxin...”
FPSE_11474 hypothetical protein from Fusarium pseudograminearum CS3096
37% identity, 94% coverage
- Transcriptomic Profiling of Fusarium pseudograminearum in Response to Carbendazim, Pyraclostrobin, Tebuconazole, and Phenamacril
Zhang, Journal of fungi (Basel, Switzerland) 2023 - “...significantly enriched, such as glycolysis/gluconeogenesis, pyruvate metabolism, vitamin B6 metabolism, and the pentose phosphate pathway. FPSE_11474 (NADP-dependent alcohol dehydrogenase 7, ADH7 ), FPSE_11514 (enolase, ENO ), FPSE_09735 (pyruvate decarboxylase, PDC ), FPSE_02221 (hexokinase, HK ), FPSE_07501 (pyruvate kinase, PK ), FPSE_11514 (acetyl-coenzyme A synthetase, ACS ),...”
- “...trend. Gene_ID Name Swiss-Port Description Log2 Foldchange (CK vs. Treatment) Cluster PYR CAR PHE TEB FPSE_11474 ADH7 NADP-dependent alcohol dehydrogenase 7 4.72 - - - 1 FPSE_11514 ENO Enolase 1.29 - 2.04 - 1 FPSE_09735 PDC Pyruvate decarboxylase 3.83 - - - 1 FPSE_07501 PK Pyruvate...”
Q7SC51 Zinc-binding alcohol dehydrogenase from Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
NCU08402 zinc-binding alcohol dehydrogenase from Neurospora crassa OR74A
36% identity, 92% coverage
- Transcriptome analysis in response to heat shock and cadmium in the aquatic fungus Blastocladiella emersonii.
Georg, Eukaryotic cell 2007 (no snippet) - Secondary Metabolism Gene Clusters Exhibit Increasingly Dynamic and Differential Expression during Asexual Growth, Conidiation, and Sexual Development in Neurospora crassa
Wang, mSystems 2022 - “...-02926 NCU02927 to -02918 PKS VM, SCM NCU02908, -02910, -02930, -02931 (SCM) 4 II (39374203969336) NCU08402 to -08403, -16586, -08404 to -08409, -16588, -08410 NCU08404 to -08407 NRPS-like BM NCU08411 to -08413 (BM); NCU08411, -08412 (SCM) 5 II (40628394096852) NCU08436 to -08443, -08445 (NCU08442) NCU08439 to...”
- Proteomic Shifts Reflecting Oxidative Stress and Reduced Capacity for Protein Synthesis, and Alterations to Mitochondrial Membranes in Neurospora crassa Lacking VDAC
Shuvo, Microorganisms 2022 - “...NCU09559 clock-controlled gene-9 NCU09674 O-methyltransferase family 3 NCU09560 superoxide dismutase NCU02812 uridylate kinase NCU05770 catalase-2 NCU08402 zinc-binding alcohol dehydrogenase NCU03739 ERP38 protein NCU02727 glycine cleavage system T protein NCU04930 hypothetical protein NCU08004 electron transfer flavoprotein alpha-subunit NCU01589 heat-shock protein 60 NCU06974 histidinol-phosphatase NCU09674 O-methyltransferase family 3...”
- Light-regulated promoters for tunable, temporal, and affordable control of fungal gene expression
Fuller, Applied microbiology and biotechnology 2018 - “...- - - X AFUA_6G00510 NADP-dependent alcohol dehydrogenase 2.7 NCU04823 - - - AN8628 X NCU08402 AFUA_6G14280 flavin-binding monooxygenase-like protein 2.6 NCU07332 BCG1_03037 - - AN5338 X AFUA_7G05730 hypothetical protein 2.6 NCU04946 - - - AN10847 X AFUA_7G00170 dimethylallyl tryptophan synthase GliD1 2.5 - - -...”
- Exploring the bZIP transcription factor regulatory network in Neurospora crassa
Tian, Microbiology (Reading, England) 2011 - “...g ene ( Takahashi et al. , 2010 )] (NCU07452), mig-3 (NCU04452), mig-6 (NCU09285) and NCU08402; an oxidase (NCU05164); catalase-2 (NCU05770); a probable reductase ( mig-4 , NCU09040); a glutathione peroxidase (NCU09534); and a predicted ABC transporter (NCU03776) (Table 4 ). We confirmed the dependence of...”
- “...gst-2 (NCU04109 and NCU05780, respectively), four NAD(P)H-dependent dehydrogenase/oxidoreductase genes, mig-2 , mig-3 , mig-6 and NCU08402, a predicted methoxylase (NCU00847), an oxidase (NCU05164) and a glutathione peroxidase (NCU09534). Six of these 34 genes are induced by menadione treatment ( Takahashi et al. , 2010 ) (Supplementary...”
NCgl0219 alcohol dehydrogenase from Corynebacterium glutamicum ATCC 13032
cg0273 alcohol dehydrogenase from Corynebacterium glutamicum ATCC 13032
34% identity, 94% coverage
- Engineered Corynebacterium glutamicum as the Platform for the Production of Aromatic Aldehydes
Kim, Frontiers in bioengineering and biotechnology 2022 - “...20 genes are as follows: P1/P2 and P3/P4 for NCgl0186 , P7/P8 and P9/P10 for NCgl0219 , P13/P14 and P15/P16 for NCgl0313 , P19/P20 and P21/P22 for NCgl0324 , P25/P26 and P27/P28 for NCgl0503 , P31/P32 and P33/P34 for NCgl0908 , P37/P38 and P39/P40 for NCgl1213...”
- “...from E. coli as a query within the C. glutamicum genome. Ten proteins, that is, NCgl0219, NCgl0313, NCgl0324, NCgl0503, NCgl1003, NCgl1112, NCgl2053, NCgl2277, NCgl2709, and NCgl2952 were classified as candidates that showed a BLASTP expect value less than E 20 . Likewise, three ADHs, that is,...”
- C1 metabolism in Corynebacterium glutamicum: an endogenous pathway for oxidation of methanol to carbon dioxide
Witthoff, Applied and environmental microbiology 2013 - “...Derivative of ATCC 13032 with in-frame deletion of cg0273 Derivative of ald strain with additional in-frame deletion of adhE gene Derivative of ald strain...”
- “...product covering upstream and downstream regions of cg0273 Kanr; pK19mobsacB derivative containing 1,084-bp PCR product covering upstream and downstream regions...”
- The alcohol dehydrogenase gene adhA in Corynebacterium glutamicum is subject to carbon catabolite repression
Arndt, Journal of bacteriology 2007 - “...in ethanol-grown cells of C. glutamicum (3). Five genes (cg0273, cg0387, cg0400, cg2714, and cg3107) were annotated as potential ADH genes in the genome of C....”
- “...gram-negative Pseudomonas aeruginosa. The other four proteins (Cg0273, Cg0387, Cg0400, and Cg2714) showed less similarity (40%) to all these ADHs. Therefore,...”
X0JRJ4 Alcohol dehydrogenase (NADP+) from Fusarium odoratissimum NRRL 54006
37% identity, 97% coverage
TRIREDRAFT_77770 uncharacterized protein from Trichoderma reesei QM6a
37% identity, 88% coverage
- Effect of the res2 transcription factor gene deletion on protein secretion and stress response in the hyperproducer strain Trichoderma reesei Rut-C30
Alharake, BMC microbiology 2023 - “...tpo4 MFS permease LC/GC -2.14 4 TRIREDRAFT_46285 hsp30 Heat shock protein 30 LC/GC 3.24 4 TRIREDRAFT_77770 Zinc-binding alcohol dehydrogenase GD/GC LC/GC 2.75 2.18 4 TRIREDRAFT_27948 csg1 G-protein-coupled receptor involved in cellulose sensing CSG1 GD/GC LC/GC 2.81 2.16 4 TRIREDRAFT_81049 erg3 Ergosterol 3 LD/LC -2.06 2 TRIREDRAFT_36822...”
- “...Rut-C30 include TRIREDRAFT_46285 encoding the chaperon HSP30, the putative alcohol dehydrogenase involved in redox reactions TRIREDRAFT_77770 and pks2 (TRIREDRAFT_65891) having roles in secretion and secretion metabolism. Also, a G-protein-coupled receptor involved in cellulose sensing csg1 (TRIREDRAFT_27948) is upregulated in GD/GC and LC/GC in in res2 only...”
VDAG_09741 NADP-dependent alcohol dehydrogenase from Verticillium dahliae VdLs.17
37% identity, 97% coverage
- Hypothetical Protein VDAG_07742 Is Required for Verticillium dahliae Pathogenicity in Potato
Wang, International journal of molecular sciences 2023 - “...upregulated proteins were randomly selected: VDAG_10194, VDAG_02304, VDAG_10208, VDAG_07442, VDAG_09254, VDAG_08248, VDAG_07373, VDAG_03665, VDAG_01700, and VDAG_09741. Basic information describing these proteins and primers used for qRT-PCR verification are listed in Tables S1 and S6 , respectively. Consistent with proteomic data obtained from TMT quantification, the mRNAs...”
- “...a Fold Enrichment p -Value Map00040 Pentose and glucuronate interconversions VDAG_10081 VDAG_02904 VDAG_04977 VDAG_05799 VDAG_08495 VDAG_09741 VDAG_06080 VDAG_06523 VDAG_06079 VDAG_02886 VDAG_08496 VDAG_09536 VDAG_08929 VDAG_05344 10.37 11.3 Map00350 Tyrosine metabolism VDAG_04798 VDAG_03345 VDAG_07316 VDAG_07507 VDAG_07314 VDAG_07369 VDAG_06372 7.04 4.49 Map00600 Sphingolipid metabolism VDAG_05015 VDAG_05347 VDAG_01556 VDAG_07821 10.23...”
KLMA_80339 NADP-dependent alcohol dehydrogenase from Kluyveromyces marxianus DMKU3-1042
39% identity, 86% coverage
- CRISPR-Cas9-enabled genetic disruptions for understanding ethanol and ethyl acetate biosynthesis in Kluyveromyces marxianus
Löbs, Biotechnology for biofuels 2017 - “...identified in the annotated genome of K. marxianus DMKU3-1042 as KLMA_40102, KLMA_40220, KLMA_80306, KLMA_20158, KLMA_20005 KLMA_80339, and KLMA_40624 for Km ADH17, respectively and KLMA_30203 for Km ATF [ 19 ]. Blast searches confirmed the presences of each gene in the unannotated genome of CBS 6556. All...”
- Genetic basis of the highly efficient yeast Kluyveromyces marxianus: complete genome sequence and transcriptome analyses
Lertwattanasakul, Biotechnology for biofuels 2015 - “...ADH3 KLMA_20005 Alcohol dehydrogenase 4a ADH4a KLMA_20158 Alcohol dehydrogenase 4b ADH4b KLMA_40624 Alcohol dehydrogenase ADH KLMA_80339 Alcohol dehydrogenase 6 ADH6 NAD, nicotinamide adenine dinucleotide; NADP, nicotinamide adenine dinucleotide phosphate. Chromosomal segments including 4,277 genes, which retain the ancestral gene groupings, were found between K. marxianus and...”
PADG_01987 uncharacterized protein from Paracoccidioides brasiliensis Pb18
33% identity, 95% coverage
6iqdA / P42327 Crystal structure of alcohol dehydrogenase from geobacillus stearothermophilus (see paper)
34% identity, 93% coverage
Bdiaspc4_29865 alcohol dehydrogenase AdhP from Bradyrhizobium diazoefficiens
bll5655 alcohol dehydrogenase from Bradyrhizobium japonicum USDA 110
32% identity, 94% coverage
- An Integrated Systems Approach Unveils New Aspects of Microoxia-Mediated Regulation in Bradyrhizobium diazoefficiens
Fernández, Frontiers in microbiology 2019 - “...Bdiaspc4_27515 Co-chaperone GroES groES 1 blr5226 3.4 2.1 Bdiaspc4_29305 CBS domain-containing protein bll5551 1.1 2.0 Bdiaspc4_29865 Alcohol dehydrogenase AdhP adhP bll5655 2.8 18.0 3.9 + Bdiaspc4_30480 Efflux RND transporter permease subunit bll5771 3.8 2.6 Bdiaspc4_30485 Efflux RND transporter periplasmic adaptor subunit bll5772 4.0 3.5 Bdiaspc4_30510 DUF302...”
- An Integrated Systems Approach Unveils New Aspects of Microoxia-Mediated Regulation in Bradyrhizobium diazoefficiens
Fernández, Frontiers in microbiology 2019 - “...blr5226 3.4 2.1 Bdiaspc4_29305 CBS domain-containing protein bll5551 1.1 2.0 Bdiaspc4_29865 Alcohol dehydrogenase AdhP adhP bll5655 2.8 18.0 3.9 + Bdiaspc4_30480 Efflux RND transporter permease subunit bll5771 3.8 2.6 Bdiaspc4_30485 Efflux RND transporter periplasmic adaptor subunit bll5772 4.0 3.5 Bdiaspc4_30510 DUF302 domain-containing protein blr5777 4.3 5.0...”
- Characterization of a Functional Role of the Bradyrhizobium japonicum Isocitrate Lyase in Desiccation Tolerance
Jeon, International journal of molecular sciences 2015 - “...five translation-related genes (bll5381, bsl5382, bsl5391, bsl5392, and bll5397), five energy metabolism genes (bll3998, bll4784, bll5655, blr6128, and blr7040), four chaperonins (blr4637, blr4653, blr5625, and blr5626), one transport (bsr4636), one nitrogen fixation (blr2764), one regulatory gene (blr2475), and one chemotaxis (bll6865). Interestingly, there were 10 hypothetical...”
- Influence of elevated atmospheric carbon dioxide on transcriptional responses of Bradyrhizobium japonicum in the soybean rhizoplane
Sugawara, Microbes and environments 2013 - “...oxidation via a glutathione-dependent formaldehyde oxidation pathway. In addition, up-regulation of other alcohol dehydrogenase genes (bll5655, blr3675) in SFJ1436 was observed following exposure to elevated CO 2 ( Table 3 ). Rhizobia have previously been shown to grow using ethanol as the sole C source (...”
- “...blr3675 1.6 1.6 Putative alcohol dehydrogenase bll4784 1.5 Aldehyde dehydrogenase bll5504 1.5 Putative polyvinyl-alcohol dehydrogenase bll5655 * 1.6 2.6 Alcohol dehydrogenase blr6207 exaA 2.0 Quinoprotein ethanol dehydrogenase blr0335 1.5 Putative carbon monoxide dehydrogenase small chain bll5664 cooxM 2.3 Putative carbon monoxide dehydrogenase medium subunit Dicarboxylic acid...”
- Comprehensive assessment of the regulons controlled by the FixLJ-FixK2-FixK1 cascade in Bradyrhizobium japonicum
Mesa, Journal of bacteriology 2008 - “...Putative cytochrome b561 Unknown protein bsr5273 bll5315 bsr5316 bll5655 bll6061 bll6069 blr6070 bll6073 blr6074 blr6128 102.6 34.4 22.5 36.2 19.1 29.4 7.3 27.9...”
A3GHR6 alcohol dehydrogenase (NADP+) (EC 1.1.1.2) from Scheffersomyces stipitis (see paper)
37% identity, 89% coverage
Q6RS93 alcohol dehydrogenase (EC 1.1.1.1) from Parageobacillus thermoglucosidasius (see paper)
31% identity, 97% coverage
A1S_3436 putative alcohol dehydrogenase from Acinetobacter baumannii ATCC 17978
36% identity, 82% coverage
P42328 alcohol dehydrogenase (EC 1.1.1.1) from Geobacillus stearothermophilus (see 8 papers)
1rjwA / P42328 Crystal structure of NAD(+)-dependent alcohol dehydrogenase from bacillus stearothermophilus strain lld-r (see paper)
32% identity, 97% coverage
- Ligands: zinc ion; trifluoroethanol (1rjwA)
- Identification and characterization of a novel formaldehyde dehydrogenase in Bacillus subtilis
Klein, Applied and environmental microbiology 2024 - “...Saccharolobus solfataricus (GenBank ID: P39462) ( 57 ); GsAHD, Adh from Geobacillus stearothermophilus (GenBank ID: P42328) ( 58 ); BsBSH-FDH, bacilithiol-dependent Fdh from B. subtilis (GenBank ID: NP_390579) ( 26 ); CbADH, Adh from Clostridium beijerinckii (GenBank ID: P25984) ( 59 ); TbADH, Adh from Thermoanaerobacter...”
- Generation of Oxidoreductases with Dual Alcohol Dehydrogenase and Amine Dehydrogenase Activity
Tseliou, Chemistry (Weinheim an der Bergstrasse, Germany) 2021 - “...from horse liver (UniProt P00327), [8] yeast (P00330),[ 8a , 9 ] Bacillus stearothermophilus (UniProt P42328, PDB 1RJW; 3PII), [10] Sulfolobus solfataricus (UniProt P39462, PDB 1R37), [11] Acinetobacter calcoaceticus (UniProt Q59096, PDB 1F8F), [12] and Thermoanaerobacter brockii (also named as Thermoanaerobacter ethanolicus , UniProt P14941, PDB...”
- Structure and Dynamics of a Thermostable Alcohol Dehydrogenase from the Antarctic Psychrophile Moraxella sp. TAE123
Petratos, ACS omega 2020 - “...coli ( Ec ADH, UniProtKB ID P39451), 12 Geobacillus stearothermophilus ( Gs ADH, UniProtKB ID P42328), 13 and Thermus sp. ATN1 ( Th ADH, UniProtKB ID B2ZRE3). 14 Moreover, circular dichroism (CD) spectropolarimetry and enzyme kinetics of Mo ADH have been carried out at varying temperatures....”
- “...Gs ADH:CF 3 CH 2 OH 0.70 1.33 25.9 (PDB ID 1RJW) (336) (311) (UniProtKB: P42328) 0.75 1.51 (1347) (1176) Th ADH:NAD + 1.56 1.60 1.59 (PDB ID 4CPD) (264) (271) (271) (UniProtKB: B2ZRE3) 1.78 1.94 1.76 (913) (715) (915) a The right diagonal half of...”
AO090038000575 No description from Aspergillus oryzae RIB40
36% identity, 92% coverage
PICST_88760 alcohol dehydrogenase (NADP dependent) from Pichia stipitis CBS 6054
PICST_88760 alcohol dehydrogenase (NADP dependent) from Scheffersomyces stipitis CBS 6054
37% identity, 87% coverage
- A constraint-based model of Scheffersomyces stipitis for improved ethanol production
Liu, Biotechnology for biofuels 2012 - “...is the common cytoplasmic ethanol pathway, the other is the mitochondrial pathway encoded by ADH3 (PICST_88760), a mitochondrial alcohol dehydrogenase (absented in i BB814). However, the latter pathway functioned only when the cytoplasmic pathway was eliminated, which had been experimentally validated [ 29 ]. The list...”
ABC0046 alcohol dehydrogenase from Bacillus clausii KSM-K16
32% identity, 90% coverage
Geoth_3823 alcohol dehydrogenase AdhP from Parageobacillus thermoglucosidasius C56-YS93
33% identity, 93% coverage
AO090023000460 No description from Aspergillus oryzae RIB40
36% identity, 90% coverage
Afu7g01980 alcohol dehydrogenase, putative from Aspergillus fumigatus Af293
38% identity, 91% coverage
- Evolutionary Analysis of Sequence Divergence and Diversity of Duplicate Genes in Aspergillus fumigatus
Yang, Evolutionary bioinformatics online 2012 - “...2.58 [2.09, 0.67] Afu8g02500 1.33 [0.64, 2.31] Afu1g17010 1.91 [2.22, 1.58] Afu1g01670 1.32 [0.47, 2.08] Afu7g01980 0.11 [1.84, 2.33] Afu3g11480 1.31 [1.12, 2.81] Afu3g07560 2.32 [2.15, 1.03] Afu8g06930 1.27 [0.26, 1.73] Afu6g12160 0.88 [1.45, 1.09] Afu1g01260 1.24 [0.55, 2.09] Afu5g09470 1.07 [1.82, 1.45] Afu6g02790 1.24 [0.66,...”
GME_RS00365 alcohol dehydrogenase AdhP from Halomonas sp. TD01
32% identity, 99% coverage
- Hyperproduction of 3-hydroxypropionate by Halomonas bluephagenesis
Jiang, Nature communications 2021 - “...Data 3 ). Several putative upregulated alcohol dehydrogenases were examined, including GME_RS01345, GME_05160, GME_RS01585 and GME_RS00365 encoding NAD(P)-dependent alcohol dehydrogenase (RefSeq. Accession: WP_009721539.1), zinc-binding alcohol dehydrogenase (GenBank Accession: EGP20677.1), zinc-binding dehydrogenase (RefSeq. Accession: WP_009721587.1), and alcohol dehydrogenase AdhP (RefSeq. Accession: WP_039868491.1), respectively (Fig. 2b ). Fig....”
- “...dehydrogenase, GME_RS01345 encodes NAD(P)-dependent alcohol dehydrogenase; GME_05160 encodes zinc-binding alcohol dehydrogenase, GME_RS01585 encodes zinc-binding dehydrogenase, GME_RS00365 encodes alcohol dehydrogenase AdhP. c 3HP production and d cell growth (DCM) and PHB content under optimal expression levels of aldehyde dehydrogenase. A stronger RBS was cloned instead of the...”
ADH6_YEAST / Q04894 NADP-dependent alcohol dehydrogenase 6; NADP-dependent alcohol dehydrogenase VI; S-nitroso-CoA reductase; ScorR; ScADHVI; EC 1.1.1.2; EC 1.6.-.- from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see 7 papers)
1piwA / Q04894 Apo and holo structures of an NADP(h)-dependent cinnamyl alcohol dehydrogenase from saccharomyces cerevisiae (see paper)
NP_014051 NADP-dependent alcohol dehydrogenase from Saccharomyces cerevisiae S288C
YMR318C Adh6p from Saccharomyces cerevisiae
36% identity, 90% coverage
- function: NADP-dependent, medium-chain alcohol dehydrogenase with a broad substrate specificity (PubMed:11742541). Aldehydes exhibited 50- 12000 times higher catalytic efficiency than the corresponding alcohols, therefore the major function of the enzyme is as an aldehyde reductase (PubMed:11742541). The enzyme is active towards aromatic and aliphatic (linear and branched-chain) aldehydes (PubMed:11742541). The enzyme is very active towards aromatic aldehydes, such as cinnamaldehyde, benzaldehyde and substituted benzaldehydes, such as veratraldehyde and panisaldehyde (PubMed:11742541). It exhibits low activity towards substituted cinnamaldehydes, such as coniferaldehyde and sinapaldehyde (PubMed:11742541). The enzyme has no activity with ketones, such as acetone or cyclohexanone (PubMed:11742541). For the reverse reaction, linear and branched-chain primary alcohols are substrates, whereas very low activity is found with secondary alcohols, such as butan-2-ol (PubMed:11742541). The enzyme may be physiologically involved in several steps of the lignin degradation pathway, initiated by other microorganisms, in the synthesis of fusel alcohols, products derived from the aminoacidic metabolism, and in the homeostasis of NADP(H) (PubMed:12604208). Has the ability to reduce 5-hydroxymethyl furfural (HMF), a furan derivative which is formed during the hydrolysis of lignocellulosic materials, to 5-hydroxymethylfurfuryl alcohol, thereby alleviating the inhibition of the fermentation of lignocellulose hydrolysates by HMF during fuel ethanol production (PubMed:16652391). Also acts as an inhibitor of protein S-nitrosylation by mediating degradation of S-nitroso-coenzyme A (S-nitroso-CoA), a cofactor required to S-nitrosylate proteins (PubMed:25512491).
catalytic activity: a primary alcohol + NADP(+) = an aldehyde + NADPH + H(+) (RHEA:15937)
catalytic activity: (E)-cinnamyl alcohol + NADP(+) = (E)-cinnamaldehyde + NADPH + H(+) (RHEA:10392)
catalytic activity: hexan-1-ol + NADP(+) = hexanal + NADPH + H(+) (RHEA:58404)
catalytic activity: 3-methylbutanol + NADP(+) = 3-methylbutanal + NADPH + H(+) (RHEA:18525)
catalytic activity: S-nitroso-CoA + NADPH + H(+) = sulfinamide-CoA + NADP(+) (RHEA:78375)
cofactor: Zn(2+) (Binds 2 Zn(2+) ions per subunit.)
subunit: Homodimer. - Ligands: zinc ion; nadp nicotinamide-adenine-dinucleotide phosphate (1piwA)
- A General Tool for Engineering the NAD/NADP Cofactor Preference of Oxidoreductases
Cahn, ACS synthetic biology 2017 - “...K35D, C68R 2.4 0.9 2.7 0.4 4.6 0.1 33 0.7 Saccharomyces cerevisae cinnamyl alcohol dehydrogenase Q04894 1PIW Rossmann (c.2.1.1) S210D, R211P, K215E, S253P 110 0.5 190 1.5 0.5 2.9 65 0.8 Talaromyces emersonii xylose reductase C5J3R6 1K8C b TIM Barrel (c.1.7.1) S272G, N273D, R277Y, Q280E 14...”
- Using quantitative redox proteomics to dissect the yeast redoxome
Brandes, The Journal of biological chemistry 2011 - “...P13663 P39954 P37292 P00931 Carbohydrate metabolism P00330 Q04894 P14540 P09624 P06169 P00358 P32614 P11986 Proteostasis and stress response P38013 P38013...”
- “...P39533 P52910 P60010 P38009 P38009 P07245 P38972 P00330 Q04894 P47143 P38013 P38013 P38013 P36112 P46367 P54115 P54115 Gene, Peptide (Cys) Protein name ABP140,...”
- Identification of S-nitroso-CoA reductases that regulate protein S-nitrosylation.
Anand, Proceedings of the National Academy of Sciences of the United States of America 2014 - GeneRIF: Adh6, acting as a selective SNO-CoA reductase, protects acetoacetyl-CoA thiolase from inhibitory S-nitrosylation and thereby affects sterol biosynthesis.
- Purification, characterization, and potential bacterial wax production role of an NADPH-dependent fatty aldehyde reductase from Marinobacter aquaeolei VT8
Wahlen, Applied and environmental microbiology 2009 - “...sequences for the MCADH from both S. cerevisiae (NP_014051) and Acinetobacter (BAB12270). No significant similarity was found. Even though the MCADH from...”
- De novo biosynthesis of berberine and halogenated benzylisoquinoline alkaloids in Saccharomyces cerevisiae
Han, Communications chemistry 2023 - “...(NMCH) from Eschscholzia californica (California poppy), and a Leu2 auxotrophic marker, were integrated into the YMR318C ( adh6 , encoding an alcohol dehydrogenase degrading 4HPAA 43 ) site of BBR1, resulting in the strain BBR2, with reticuline production verified (Supplementary Fig. S1b ). Module IV contains...”
- Improving heterologous production of phenylpropanoids in Saccharomyces cerevisiae by tackling an unwanted side reaction of Tsc13, an endogenous double-bond reductase
Lehka, FEMS yeast research 2017 - “...). Genotype Systematic name oye2/oye2 YHR179W ylr460c/ylr460c YLR460C adh7/adh7 YCR105W ydr541c/ydr541c YDR541C gre2/gre2 YOL151W adh6/adh6 YMR318C yml131w/yml131w YML131W ymr226c/ymr226c YMR226C oye3/oye3 YPL171C ypl088w/ypl088w YPL088W aad4/aad4 YDL243C aad6/aad6 YFL056C dfg10/dfg10 YIL049W zta1/zta1 YBR046C ari1/ari1 YGL157W aad3/aad3 YCR107W frd1/frd1 YEL047C shh3/shh3 YMR118C osm1/osm1 YJR051W lot6/lot6 YLR011W ayr1/ayr1 YIL124W...”
- Different Toxicity Mechanisms for Citrinin and Ochratoxin A Revealed by Transcriptomic Analysis in Yeast
Vanacloig-Pedros, Toxins 2016 - “...AN1-type zinc finger protein of unknown function YOL155C HPF1 5.8 6.09 10 5 Haze-protective mannoprotein YMR318C ADH6 5.8 7.64 10 3 NADPH-dependent medium chain alcohol dehydrogenase YJL082W IML2 5.8 4.56 10 4 Protein of unknown function YKL051W SFK1 5.6 6.62 10 6 Plasma membrane protein that...”
- State of the art of fuzzy methods for gene regulatory networks inference
Al, TheScientificWorldJournal 2015 - “...downregulated by genes YIR0317C and YMR317W (1 on the arrow); upregulated by genes YDL177C and YMR318C (1 on the arrow). 7. Conclusion Fuzzy approach provides useful means for GRNs inference as reported in the diversified methods described in this paper. This is due to the fact...”
- Construction and application of a protein and genetic interaction network (yeast interactome)
Stuart, Nucleic acids research 2009 - “...physiological role YML116W ATR1 7.41 Multidrug efflux pump; required for resistance to aminotriazole and 4-nitroquinoline-N-oxide YMR318C ADH6 7.67 NADPH-dependent cinnamyl alcohol dehydrogenase; possible role in fusel alcohol synthesis or aldehyde tolerance YLR460C YLR460C 8.32 Hypothetical protein YER055C HIS1 8.99 ATP phosphoribosyltransferase, a hexameric enzyme, catalyzes the...”
- “...a physiological role YML116W ATR1 7.41 Multidrug efflux pump; required for resistance to aminotriazole, 4-nitroquinoline-N-oxide YMR318C ADH6 7.67 NADPH-dependent alcohol dehydrogenase; possibly involved in fusel alcohol synthesis or aldehyde tolerance YDL243C AAD4 7.91 Putative aryl-alcohol dehydrogenase; involved in the oxidative stress response a Each of these...”
- Transcription factor control of growth rate dependent genes in Saccharomyces cerevisiae: a three factor design
Fazio, BMC genomics 2008 - “...small (40S) subunit; nearly identical to Rps1Ap and has similarity to rat S3a ribosomal protein YMR318C ADH6 NADPH-dependent medium chain alcohol dehydrogenase with broad substrate specificity; member of the cinnamyl family of alcohol dehydrogenases; may be involved in fusel alcohol synthesis or in aldehyde tolerance YOL040C...”
- Physiological and transcriptional responses of Saccharomyces cerevisiae to zinc limitation in chemostat cultures
De, Applied and environmental microbiology 2007 - “...LYS20, OYE2, OYE3, TRR1, TRX2, YDR453C, YLR460C, YNL134C, YMR318C, and YML131W) (40). Although the transcript levels of both SOD1 and SOD2 were reduced, their...”
- Analysis of beta-1,3-glucan assembly in Saccharomyces cerevisiae using a synthetic interaction network and altered sensitivity to caspofungin
Lesage, Genetics 2004 - “...PDA1 PFK2 RPL16B RPL20B RPL29 RPS0A RPS21B TYR1 YMR318C YJR118C YLR320W YNL294C YAL053W YBL062W YGL046W YGL081W ADH6 ILM1 MMS22 RIM21 YGL110C YGL196W YGR237C...”
- More
NCU00260 oxidoreductase from Neurospora crassa OR74A
37% identity, 94% coverage
pRL90027 putative alcohol dehydrogenase from Rhizobium leguminosarum bv. viciae 3841
31% identity, 93% coverage
Q8L3C9 alcohol dehydrogenase (EC 1.1.1.1) from Flavobacterium frigidimaris (see paper)
29% identity, 94% coverage
patD / A0A075TMP0 neopatulin dehydrogenase from Penicillium expansum (see paper)
PATD_PENEN / A0A075TMP0 Alcohol dehydrogenase patD; Patulin biosynthesis cluster protein D; EC 1.1.1.- from Penicillium expansum (Blue mold rot fungus) (see 8 papers)
34% identity, 93% coverage
- function: Alcohol dehydrogenase; part of the gene cluster that mediates the biosynthesis of patulin, an acetate-derived tetraketide mycotoxin produced by several fungal species that shows antimicrobial properties against several bacteria (PubMed:25625822, PubMed:30100914, PubMed:30680886). PatD catalyzes the conversion of neopatulin into E- ascladiol (PubMed:30680886). The pathway begins with the synthesis of 6-methylsalicylic acid by the polyketide synthase (PKS) patK via condensation of acetate and malonate units. The 6-methylsalicylic acid decarboxylase patG then catalyzes the decarboxylation of 6- methylsalicylic acid to yield m-cresol (also known as 3-methylphenol). These first reactions occur in the cytosol. The intermediate m-cresol is then transported into the endoplasmic reticulum where the cytochrome P450 monooxygenase patH converts it to m-hydroxybenzyl alcohol, which is further converted to gentisyl alcohol by the cytochrome P450 monooxygenase patI. The oxidoreductases patJ and patO further convert gentisyl alcohol to isoepoxydon in the vacuole. PatN catalyzes then the transformation of isoepoxydon into phyllostine. The cluster protein patF is responsible for the conversion from phyllostine to neopatulin whereas the alcohol dehydrogenase patD converts neopatulin to E- ascladiol. The steps between isoepoxydon and E-ascladiol occur in the cytosol, and E-ascladiol is probably secreted to the extracellular space by one of the cluster-specific transporters patC or patM. Finally, the secreted patulin synthase patE catalyzes the conversion of E-ascladiol to patulin (Probable) (PubMed:30680886).
catalytic activity: neopatulin + NADPH + H(+) = (E)-ascladiol + NADP(+) (RHEA:62224)
cofactor: Zn(2+) (Binds 2 Zn(2+) ions per subunit.)
disruption phenotype: Strongly reduces the production of patulin.
CH_124303 alcohol dehydrogenase 1 from Magnaporthe grisea 70-15 (see paper)
31% identity, 93% coverage
HA399_02440 alcohol dehydrogenase AdhP from Cobetia sp. UIB-001
31% identity, 99% coverage
- "The Good, the Bad and the Double-Sword" Effects of Microplastics and Their Organic Additives in Marine Bacteria
Fernández-Juárez, Frontiers in microbiology 2020 - “...here when two proteins related to plastic degradation (alcohol dehydrogenase [ADH] of 342 amino acids, HA399_02440) and carbon transport (C4-dicarboxylate ABC transporter substrate-binding protein [C4-ABCS] of 329 amino acids, HA399_06715) were overproduced in the heterotroph Cobetia sp., but were not detectable with the MALDI-TOF analyses in...”
- “...et al., 2019 ). Figure 4 Structural analysis of alcohol dehydrogenase (ADH) from Cobetia sp. (HA399_02440). (A) Protein prediction of ADH showing, (B) the nicotinamide-adenine-dinucleotide (NAD) dependence, displaying the ligand binding residues HIS 43, THR 44, SER 174, GLY 175, GLY 177, GLY 178, LEU 179,...”
RR42_RS34260 Alcohol dehydrogenase (EC 1.1.1.1) from Cupriavidus basilensis FW507-4G11
31% identity, 99% coverage
- mutant phenotype: Specifically important for utilizing Ethanol. Automated validation from mutant phenotype: the predicted function (ALCOHOL-DEHYDROG-RXN) was linked to the condition via a MetaCyc pathway. This annotation was also checked manually.
NOTN_ASPSM / E1ACQ9 Alcohol dehydrogenase notN; Notoamide biosynthesis cluster protein N; EC 1.1.1.1 from Aspergillus sp. (strain MF297-2) (see 3 papers)
33% identity, 94% coverage
- function: Alcohol dehydrogenase; part of the gene cluster that mediates the biosynthesis of notoamide, a fungal indole alkaloid that belongs to a family of natural products containing a characteristic bicyclo[2.2.2]diazaoctane core (PubMed:20722388). The first step of notoamide biosynthesis involves coupling of L-proline and L-tryptophan by the bimodular NRPS notE, to produce cyclo-L-tryptophan-L-proline called brevianamide F (PubMed:20722388). The reverse prenyltransferase notF then acts as a deoxybrevianamide E synthase and converts brevianamide F to deoxybrevianamide E via reverse prenylation at C-2 of the indole ring leading to the bicyclo[2.2.2]diazaoctane core (PubMed:20722388). Deoxybrevianamide E is further hydroxylated at C-6 of the indole ring, likely catalyzed by the cytochrome P450 monooxygenase notG, to yield 6-hydroxy-deoxybrevianamide E (Probable). 6-hydroxy-deoxybrevianamide E is a specific substrate of the prenyltransferase notC for normal prenylation at C-7 to produce 6- hydroxy-7-prenyl-deoxybrevianamide, also called notoamide S (PubMed:20722388). As the proposed pivotal branching point in notoamide biosynthesis, notoamide S can be diverted to notoamide E through an oxidative pyran ring closure putatively catalyzed by either notH cytochrome P450 monooxygenase or the notD FAD-linked oxidoreductase (Probable). This step would be followed by an indole 2,3-epoxidation- initiated pinacol-like rearrangement catalyzed by the notB FAD- dependent monooxygenase leading to the formation of notoamide C and notoamide D (PubMed:22188465). On the other hand notoamide S is converted to notoamide T by notH (or notD), a bifunctional oxidase that also functions as the intramolecular Diels-Alderase responsible for generation of (+)-notoamide T (Probable). To generate antipodal (-)- notoaminide T, notH' (or notD') in Aspergillus versicolor is expected to catalyze a Diels-Alder reaction leading to the opposite stereochemistry (Probable). The remaining oxidoreductase notD (or notH) likely catalyzes the oxidative pyran ring formation to yield (+)- stephacidin A (Probable). The FAD-dependent monooxygenase notI is highly similar to notB and is predicted to catalyze a similar conversion from (+)-stephacidin A to (-)-notoamide B via the 2,3- epoxidation of (+)-stephacidin A followed by a pinacol-type rearrangement (Probable). Finally, it remains unclear which enzyme could be responsible for the final hydroxylation steps leading to notoamide A and sclerotiamide (Probable). The function of notN in the notoamide biosynthesis has not been determined yet (Probable).
catalytic activity: a primary alcohol + NAD(+) = an aldehyde + NADH + H(+) (RHEA:10736)
catalytic activity: a secondary alcohol + NAD(+) = a ketone + NADH + H(+) (RHEA:10740)
cofactor: Zn(2+) (Binds 2 Zn(2+) ions per subunit.)
4z6kA / Q8GIX7 Alcohol dehydrogenase from the antarctic psychrophile moraxella sp. Tae 123
33% identity, 92% coverage
AAur_3063 Zn-dependent alcohol dehydrogenase from Arthrobacter aurescens TC1
A1R952 alcohol dehydrogenase from Paenarthrobacter aurescens (strain TC1)
30% identity, 98% coverage
Cbei_3864 alcohol dehydrogenase from Clostridium beijerincki NCIMB 8052
31% identity, 91% coverage
- Molecular characterization of an NADPH-dependent acetoin reductase/2,3-butanediol dehydrogenase from Clostridium beijerinckii NCIMB 8052
Raedts, Applied and environmental microbiology 2014 - “...CBEI_0685, CBEI_1464 (C. beijerinckii ACR [Cb-ACR]), CBEI_2243, CBEI_3864, and CBEI_3890, were amplified by PCR on C. beijerinckii genomic DNA using the...”
- “...CBEI_0223, CBEI_0528, CBEI_0544, CBEI_0685, CBEI_1464, CBEI_2243, CBEI_3864, and CBEI_3890 are all annotated in NCBI (http://www.ncbi.nlm.nih.gov/) as alcohol...”
ADH_MORSE / Q8GIX7 Alcohol dehydrogenase; ADH; EC 1.1.1.1 from Moraxella sp. (strain TAE123) (see 3 papers)
Q8GIX7 alcohol dehydrogenase (EC 1.1.1.1) from Moraxella sp. (see paper)
33% identity, 90% coverage
- function: Psychrophilic alcohol dehydrogenase that exhibits a wide range of substrate specificity, oxidizing mainly primary and secondary aliphatic alcohols, utilizing NAD(+) as a cosubstrate. In vitro, shows highest reaction rates for ethanol as a substrate and gradually decreases its reaction rates as the length and branching of the carbon chain of the alcohol substrates increase. To a lesser extent, is also able to reduce aldehydes and ketones. Do not catalyze the further oxidation of aldehydes to carboxylic acids. Cannot use NADP(+) instead of NAD(+).
catalytic activity: a primary alcohol + NAD(+) = an aldehyde + NADH + H(+) (RHEA:10736)
catalytic activity: a secondary alcohol + NAD(+) = a ketone + NADH + H(+) (RHEA:10740)
catalytic activity: ethanol + NAD(+) = acetaldehyde + NADH + H(+) (RHEA:25290)
catalytic activity: 1-propanol + NAD(+) = propanal + NADH + H(+) (RHEA:50704)
catalytic activity: butan-1-ol + NAD(+) = butanal + NADH + H(+) (RHEA:33199)
catalytic activity: propan-2-ol + NAD(+) = acetone + NADH + H(+) (RHEA:41984)
cofactor: Zn(2+) (Binds 2 Zn(2+) ions per subunit. One metal ion is located at the active-site region and has been termed catalytic, while the second metal ion has been termed structural.)
subunit: Homotetramer. - Structure and Dynamics of a Thermostable Alcohol Dehydrogenase from the Antarctic Psychrophile Moraxella sp. TAE123
Petratos, ACS omega 2020 - “...90 prokaryotic ADHs. 8 The ADH from the psychrophilic bacterium Moraxella sp. TAE123 (UniProtKB ID Q8GIX7) with an engineered hexahistidine tag at the carboxy terminus (hereafter Mo ADH) has been purified and crystallized, and the phases have been determined. 9 In the present work, the refined...”
- “...ADH (>40) Th ADH (>60) Mo ADH a 44.5 59.6 23.6 (PDB ID 4Z6K) (UniProtKB: Q8GIX7) Ec ADH:NAD + 1.28 54.1 24.1 (PDB ID 4GKV) (314) (UniProtKB: P39451) 1.46 (1195) Gs ADH:CF 3 CH 2 OH 0.70 1.33 25.9 (PDB ID 1RJW) (336) (311) (UniProtKB: P42328)...”
CCM_02761 oxidoreductase from Cordyceps militaris CM01
38% identity, 97% coverage
- Transcriptome-wide analysis reveals the progress of Cordyceps militaris subculture degeneration
Yin, PloS one 2017 - “...This study showed that the expression of the genes encoding s-adenosylhomocysteine nucleosidase (CCM_02372) and oxidordeuctase (CCM_02761) was significantly down-regulated, and that of genes encoding adenine nucleotide alpha hydrolases like (CCM_07740) andadenine nucleotide alpha hydrolases like (CCM_08422) were significantly up-regulated during the degeneration progress. Ergosterol is one...”
HELO_2818 alcohol dehydrogenase AdhP from Halomonas elongata DSM 2581
31% identity, 94% coverage
BAB1_0204 Zinc-containing alcohol dehydrogenase superfamily:Zinc-containing alcohol dehydrogenase from Brucella melitensis biovar Abortus 2308
Q2YP66 alcohol dehydrogenase from Brucella abortus (strain 2308)
BCAN_A0207 Alcohol dehydrogenase from Brucella canis ATCC 23365
30% identity, 98% coverage
For advice on how to use these tools together, see
Interactive tools for functional annotation of bacterial genomes.
The PaperBLAST database links 793,807 different protein sequences to 1,259,118 scientific articles. Searches against EuropePMC were last performed on March 13 2025.
PaperBLAST builds a database of protein sequences that are linked
to scientific articles. These links come from automated text searches
against the articles in EuropePMC
and from manually-curated information from GeneRIF, UniProtKB/Swiss-Prot,
BRENDA,
CAZy (as made available by dbCAN),
BioLiP,
CharProtDB,
MetaCyc,
EcoCyc,
TCDB,
REBASE,
the Fitness Browser,
and a subset of the European Nucleotide Archive with the /experiment tag.
Given this database and a protein sequence query,
PaperBLAST uses protein-protein BLAST
to find similar sequences with E < 0.001.
To build the database, we query EuropePMC with locus tags, with RefSeq protein
identifiers, and with UniProt
accessions. We obtain the locus tags from RefSeq or from MicrobesOnline. We use
queries of the form "locus_tag AND genus_name" to try to ensure that
the paper is actually discussing that gene. Because EuropePMC indexes
most recent biomedical papers, even if they are not open access, some
of the links may be to papers that you cannot read or that our
computers cannot read. We query each of these identifiers that
appears in the open access part of EuropePMC, as well as every locus
tag that appears in the 500 most-referenced genomes, so that a gene
may appear in the PaperBLAST results even though none of the papers
that mention it are open access. We also incorporate text-mined links
from EuropePMC that link open access articles to UniProt or RefSeq
identifiers. (This yields some additional links because EuropePMC
uses different heuristics for their text mining than we do.)
For every article that mentions a locus tag, a RefSeq protein
identifier, or a UniProt accession, we try to select one or two
snippets of text that refer to the protein. If we cannot get access to
the full text, we try to select a snippet from the abstract, but
unfortunately, unique identifiers such as locus tags are rarely
provided in abstracts.
PaperBLAST also incorporates manually-curated protein functions:
- Proteins from NCBI's RefSeq are included if a
GeneRIF
entry links the gene to an article in
PubMed®.
GeneRIF also provides a short summary of the article's claim about the
protein, which is shown instead of a snippet.
- Proteins from Swiss-Prot (the curated part of UniProt)
are included if the curators
identified experimental evidence for the protein's function (evidence
code ECO:0000269). For these proteins, the fields of the Swiss-Prot entry that
describe the protein's function are shown (with bold headings).
- Proteins from BRENDA,
a curated database of enzymes, are included if they are linked to a paper in PubMed
and their full sequence is known.
- Every protein from the non-redundant subset of
BioLiP,
a database
of ligand-binding sites and catalytic residues in protein structures, is included. Since BioLiP itself
does not include descriptions of the proteins, those are taken from the
Protein Data Bank.
Descriptions from PDB rely on the original submitter of the
structure and cannot be updated by others, so they may be less reliable.
(For SitesBLAST and Sites on a Tree, we use a larger subset of BioLiP so that every
ligand is represented among a group of structures with similar sequences, but for
PaperBLAST, we use the non-redundant set provided by BioLiP.)
- Every protein from EcoCyc, a curated
database of the proteins in Escherichia coli K-12, is included, regardless
of whether they are characterized or not.
- Proteins from the MetaCyc metabolic pathway database
are included if they are linked to a paper in PubMed and their full sequence is known.
- Proteins from the Transport Classification Database (TCDB)
are included if they have known substrate(s), have reference(s),
and are not described as uncharacterized or putative.
(Some of the references are not visible on the PaperBLAST web site.)
- Every protein from CharProtDB,
a database of experimentally characterized protein annotations, is included.
- Proteins from the CAZy database of carbohydrate-active enzymes
are included if they are associated with an Enzyme Classification number.
Even though CAZy does not provide links from individual protein sequences to papers,
these should all be experimentally-characterized proteins.
- Proteins from the REBASE database
of restriction enzymes are included if they have known specificity.
- Every protein with an evidence-based reannotation (based on mutant phenotypes)
in the Fitness Browser is included.
- Sequence-specific transcription factors (including sigma factors and DNA-binding response regulators)
with experimentally-determined DNA binding sites from the
PRODORIC database of gene regulation in prokaryotes.
- Putative transcription factors from RegPrecise
that have manually-curated predictions for their binding sites. These predictions are based on
conserved putative regulatory sites across genomes that contain similar transcription factors,
so PaperBLAST clusters the TFs at 70% identity and retains just one member of each cluster.
- Coding sequence (CDS) features from the
European Nucleotide Archive (ENA)
are included if the /experiment tag is set (implying that there is experimental evidence for the annotation),
the nucleotide entry links to paper(s) in PubMed,
and the nucleotide entry is from the STD data class
(implying that these are targeted annotated sequences, not from shotgun sequencing).
Also, to filter out genes whose transcription or translation was detected, but whose function
was not studied, nucleotide entries or papers with more than 25 such proteins are excluded.
Descriptions from ENA rely on the original submitter of the
sequence and cannot be updated by others, so they may be less reliable.
Except for GeneRIF and ENA,
the curated entries include a short curated
description of the protein's function.
For entries from BioLiP, the protein's function may not be known beyond binding to the ligand.
Many of these entries also link to articles in PubMed.
For more information see the
PaperBLAST paper (mSystems 2017)
or the code.
You can download PaperBLAST's database here.
Changes to PaperBLAST since the paper was written:
- November 2023: incorporated PRODORIC and RegPrecise. Many PRODORIC entries were not linked to a protein sequence (no UniProt identifier), so we added this information.
- February 2023: BioLiP changed their download format. PaperBLAST now includes their non-redundant subset. SitesBLAST and Sites on a Tree use a larger non-redundant subset that ensures that every ligand is represented within each cluster. This should ensure that every binding site is represented.
- June 2022: incorporated some coding sequences from ENA with the /experiment tag.
- March 2022: incorporated BioLiP.
- April 2020: incorporated TCDB.
- April 2019: EuropePMC now returns table entries in their search results. This has expanded PaperBLAST's database, but most of the new entries are of low relevance, and the resulting snippets are often just lists of locus tags with annotations.
- February 2018: the alignment page reports the conservation of the hit's functional sites (if available from from Swiss-Prot or UniProt)
- January 2018: incorporated BRENDA.
- December 2017: incorporated MetaCyc, CharProtDB, CAZy, REBASE, and the reannotations from the Fitness Browser.
- September 2017: EuropePMC no longer returns some table entries in their search results. This has shrunk PaperBLAST's database, but has also reduced the number of low-relevance hits.
Many of these changes are described in Interactive tools for functional annotation of bacterial genomes.
PaperBLAST cannot provide snippets for many of the papers that are
published in non-open-access journals. This limitation applies even if
the paper is marked as "free" on the publisher's web site and is
available in PubmedCentral or EuropePMC. If a journal that you publish
in is marked as "secret," please consider publishing elsewhere.
Many important articles are missing from PaperBLAST, either because
the article's full text is not in EuropePMC (as for many older
articles), or because the paper does not mention a protein identifier such as a locus tag, or because of PaperBLAST's heuristics. If you notice an
article that characterizes a protein's function but is missing from
PaperBLAST, please notify the curators at UniProt
or add an entry to GeneRIF.
Entries in either of these databases will eventually be incorporated
into PaperBLAST. Note that to add an entry to UniProt, you will need
to find the UniProt identifier for the protein. If the protein is not
already in UniProt, you can ask them to create an entry. To add an
entry to GeneRIF, you will need an NCBI Gene identifier, but
unfortunately many prokaryotic proteins in RefSeq do not have
corresponding Gene identifers.
References
PaperBLAST: Text-mining papers for information about homologs.
M. N. Price and A. P. Arkin (2017). mSystems, 10.1128/mSystems.00039-17.
Europe PMC in 2017.
M. Levchenko et al (2017). Nucleic Acids Research, 10.1093/nar/gkx1005.
Gene indexing: characterization and analysis of NLM's GeneRIFs.
J. A. Mitchell et al (2003). AMIA Annu Symp Proc 2003:460-464.
UniProt: the universal protein knowledgebase.
The UniProt Consortium (2016). Nucleic Acids Research, 10.1093/nar/gkw1099.
BRENDA in 2017: new perspectives and new tools in BRENDA.
S. Placzek et al (2017). Nucleic Acids Research, 10.1093/nar/gkw952.
The EcoCyc database: reflecting new knowledge about Escherichia coli K-12.
I. M. Keeseler et al (2016). Nucleic Acids Research, 10.1093/nar/gkw1003.
The MetaCyc database of metabolic pathways and enzymes.
R. Caspi et al (2018). Nucleic Acids Research, 10.1093/nar/gkx935.
CharProtDB: a database of experimentally characterized protein annotations.
R. Madupu et al (2012). Nucleic Acids Research, 10.1093/nar/gkr1133.
The carbohydrate-active enzymes database (CAZy) in 2013.
V. Lombard et al (2014). Nucleic Acids Research, 10.1093/nar/gkt1178.
The Transporter Classification Database (TCDB): recent advances
M. H. Saier, Jr. et al (2016). Nucleic Acids Research, 10.1093/nar/gkv1103.
REBASE - a database for DNA restriction and modification: enzymes, genes and genomes.
R. J. Roberts et al (2015). Nucleic Acids Research, 10.1093/nar/gku1046.
Deep annotation of protein function across diverse bacteria from mutant phenotypes.
M. N. Price et al (2016). bioRxiv, 10.1101/072470.
by Morgan Price,
Arkin group
Lawrence Berkeley National Laboratory