PaperBLAST
PaperBLAST Hits for sp|Q9HZ66|SERC_PSEAE Phosphoserine aminotransferase OS=Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) OX=208964 GN=serC PE=1 SV=1 (361 a.a., MSKRAFNFCA...)
Show query sequence
>sp|Q9HZ66|SERC_PSEAE Phosphoserine aminotransferase OS=Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) OX=208964 GN=serC PE=1 SV=1
MSKRAFNFCAGPAALPDAVLQRAQAELLDWRGKGLSVMEMSHRSDDYVAIASKAEQDLRD
LLDIPSDYKVLFLQGGASQQFAEIPLNLLPEDGVADYIDTGIWSKKAIEEARRYGTVNVA
ASAKEYDYFAIPGQNEWTLTKDAAYVHYASNETIGGLEFDWIPETGDVPLVTDMSSDILS
RPLDVSRFGLIYAGAQKNIGPSGLVVVIVREDLLGRARSVCPTMLNYKTAADNGSMYNTP
ATYSWYLSGLVFEWLKEQGGVTAMEQRNRAKKDLLYKTIDASDFYTNPIQPSARSWMNVP
FRLADERLDKPFLEGAEARGLLNLKGHRSVGGMRASIYNALGLDAVEALVAYMAEFEKEH
G
Running BLASTp...
Found 115 similar proteins in the literature:
PA3167 phosphoserine aminotransferase from Pseudomonas aeruginosa PAO1
100% identity, 100% coverage
- A theoretical and experimental proteome map of Pseudomonas aeruginosa PAO1
Lecoutere, MicrobiologyOpen 2012 - “...0.343 79 PA3165 hisC2 Histidinol-phosphate aminotransferase E C 39.5 41 5.05 5.01 0.553 0.058 80 PA3167 serC 3-phosphoserine aminotransferase HE C 39.9 43 4.96 4.92 0.598 0.238 81 PA3173 Short-chain dehydrogenase IQR C 26.3 29 5.09 5.12 0.692 0.031 82 PA3190 Sugar-binding ABC transporter G P...”
- Toxicogenomic response of Pseudomonas aeruginosa to ortho-phenylphenol
Nde, BMC genomics 2008 - “...metabolism PA3525_argG_at PA3525 2.45 0.0411 argininosuccinate synthase arg G Amino acid biosynthesis and metabolism PA3167_serC_at PA3167 2.345 0.0396 3-phosphoserine aminotransferase ser C Amino acid biosynthesis and metabolism PA0904_lysC_at PA0904 2.337 0.00528 aspartate kinase alpha and beta chain lys C Amino acid biosynthesis and metabolism PA5263_argH_at PA5263...”
PA14_23270 3-phosphoserine aminotransferase from Pseudomonas aeruginosa UCBPP-PA14
100% identity, 100% coverage
- A novel small RNA is important for biofilm formation and pathogenicity in Pseudomonas aeruginosa
Taylor, PloS one 2017 - “...large chain +2.17 1.56 PA14_21750 Putative acetyltransferase -1.38 0.33 PA14_23090 Putative 2-Keto-3-deoxy-6-phosphogluconate aldolase -1.90 0.09 PA14_23270 serC 3-Phosphoserine aminotransferase -2.16 0.09 PA14_25400 Putative phosphodiesterase -3.25 0.15 PA14_37965 cynS Cyanate hydratase +1.06 0.33 PA14_38090 Putative pseudouridylate synthase +1.33 0.71 PA14_47100 ilvA2 Threonine dehydrastase +1.83 0.88 PA14_47670 cobT...”
PP1768 3-phosphoserine aminotransferase from Pseudomonas putida KT2440
89% identity, 100% coverage
ABO_1750 phosphoserine aminotransferase from Alcanivorax borkumensis SK2
64% identity, 99% coverage
W6QWX6 Phosphoserine aminotransferase from Ectopseudomonas oleovorans (strain CECT 5344)
61% identity, 99% coverage
NE0333 Aminotransferase class-V:Phosphoserine aminotransferase from Nitrosomonas europaea ATCC 19718
60% identity, 97% coverage
HSERO_RS18435 3-phosphoserine/phosphohydroxythreonine transaminase from Herbaspirillum seropedicae SmR1
58% identity, 96% coverage
3qboB Crystal structure of phosphoserine aminotransferase from yersinia pestis co92
57% identity, 99% coverage
- Ligand: pyridoxal-5'-phosphate (3qboB)
P19689 Phosphoserine aminotransferase from Yersinia enterocolitica serotype O:8 / biotype 1B (strain NCTC 13174 / 8081)
57% identity, 99% coverage
Q8ZGB4 Phosphoserine aminotransferase from Yersinia pestis
57% identity, 99% coverage
- Faster Smith-Waterman database searches with inter-sequence SIMD parallelisation.
Rognes, BMC bioinformatics 2011 - “...32 query sequences with accession numbers P56980, O29181, P03630, P02232, P01111, P05013, P14942, P00762, P53765, Q8ZGB4, P03989 (replacing the identical but obsolete P10318), P07327, P01008, P10635, P58229, P25705, P03435, P42357, P21177, Q38941, O60341, P27895, P07756, P04775, P19096, P28167, P0C6B8, P20930, P08519, Q7TMA5, P33450 and Q9UKN1, ranging...”
- CUDA compatible GPU cards as efficient hardware accelerators for Smith-Waterman sequence alignment.
Manavski, BMC bioinformatics 2008 - “...O29181 63 1849 3561 197 P03630 127 1889 3612 317 P53765 255 1811 3428 428 Q8ZGB4 361 1810 3446 486 P58229 511 1795 3353 533 Substitution matrix used: BLOSUM50. Gap-open penalty: 10. Gap-extension penalty: 2. Database used: SwissProt (Dec. 2006 250,296 proteins and 91,694,534 amino acids)....”
- “...3612 93 119 5.7 1948 P53765 255 12.31 1811 6.505 3428 184 121 11 2027 Q8ZGB4 361 17.44 1810 9.162 3446 275 114 16.3 1936 P58229 511 24.89 1795 13.326 3353 362 123 16.6 2691 Substitution matrix used: BLOSUM50. Gap-open penalty: 10. Gap-extension penalty: 2. Database...”
- CBESW: sequence alignment on the Playstation 3.
Wirawan, BMC bioinformatics 2008 - “...are O29181 , P03630 , P02232 , P05013 , P14942 , P00762 , P53675 , Q8ZGB4 , P10318 , P07327 , P01008 , P10635 , P58229 , P25705 , P42357 , P21177 , Q38941 and O60341 , respectively. All queries were run against Swiss-Prot release 55.2...”
- “...189 19.6 1,258 P14942 222 20.12 1,439 P00762 246 20.24 1,586 P53765 255 20.43 1,628 Q8ZGB4 361 22.04 2,137 P10318 362 22.06 2,141 P07327 374 22.39 2,179 P01008 464 23.18 2,612 P10635 497 23.69 2,737 P58229 511 24.43 2,729 P25705 553 24.74 2,916 P42357 657 26.64...”
SerC / b0907 phosphoserine/phosphohydroxythreonine aminotransferase (EC 2.6.1.52; EC 2.6.1.17) from Escherichia coli K-12 substr. MG1655 (see 21 papers)
serC / P23721 phosphoserine/phosphohydroxythreonine aminotransferase (EC 2.6.1.52; EC 2.6.1.17) from Escherichia coli (strain K12) (see 21 papers)
SERC_ECOLI / P23721 Phosphoserine aminotransferase; Phosphohydroxythreonine aminotransferase; PSAT; EC 2.6.1.52 from Escherichia coli (strain K12) (see 3 papers)
P23721 phosphoserine transaminase (EC 2.6.1.52) from Escherichia coli (see paper)
serC phosphoserine aminotransferase; EC 2.6.1.52 from Escherichia coli K12 (see 9 papers)
b0907 phosphoserine aminotransferase from Escherichia coli str. K-12 substr. MG1655
NP_415427 phosphoserine/phosphohydroxythreonine aminotransferase from Escherichia coli str. K-12 substr. MG1655
57% identity, 98% coverage
- function: Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine. Is involved in both pyridoxine and serine biosynthesis.
catalytic activity: O-phospho-L-serine + 2-oxoglutarate = 3-phosphooxypyruvate + L-glutamate (RHEA:14329)
catalytic activity: 4-(phosphooxy)-L-threonine + 2-oxoglutarate = (R)-3-hydroxy-2- oxo-4-phosphooxybutanoate + L-glutamate (RHEA:16573)
cofactor: pyridoxal 5'-phosphate (Binds 1 pyridoxal phosphate per subunit.)
subunit: Homodimer. - Essential Genome of the Metabolically Versatile Alphaproteobacterium Rhodopseudomonas palustris
Pechter, Journal of bacteriology 2015 - “...serC b3735 b2818 b3957 b2019 b3774 b1136 b0003 b0907 atpH argA argE hisG ilvC icd thrB serC ATP synthase F0F1 subunit N-Acetylglutamate synthase Acetylornithine...”
- Quantitative assessment of thermodynamic constraints on the solution space of genome-scale metabolic models
Hamilton, Biophysical journal 2013 - “...(corrected) RTMFA RTMFA (corrected) Better in TMFA b0907 serC Nonlethal Lethal Nonlethal Nonlethal Nonlethal Nonlethal b0928 aspC Nonlethal Lethal Nonlethal...”
- Genome-scale analysis to the impact of gene deletion on the metabolism of E. coli: constraint-based simulation approach
Xu, BMC bioinformatics 2009 - “...b0415, b0417 b3771 b0091 b0914 b2838 b0420, b0421, b0423 b3774 b0954 b0915 b3359 b0475, b0750, b0907 b1093 b0918 b3433 b1096, b1208, b1210 b1094 b1094 b3809 b1277, b1662, b1740 b1288 b1215 s0001 b1812, b2103, b2153 b2323 b3198 b2315, b2320, b2400 b3176 b3633 b2515, b2530, b2564 b3189 b2574,...”
- “...b3960 b4006, b4177 s0001 b4244, b4245 SS NSP CAC GSM TTPM TIM genes b0639 b0720 b0907 b0908, b1260 b0914 b1098 b1136 b1261, b1262 s0001 b2827 b1263, b1264 b3648 b1693, b2329 s0001 b2599, b2600 b3389 SS AAM FM ACM HM CM genes b0928 b1415 b1415 b2019, b2020...”
- Experimental and computational assessment of conditionally essential genes in Escherichia coli
Joyce, Journal of bacteriology 2006 - “...proB (b0242) proC (b0386) serA (b2913) serB (b4388) serC (b0907) thrA (b0002) thrB (b0003) thrC (b0004) trpA (b1260) trpB (b1261) trpC (b1262) trpD (b1263) trpE...”
- Interfering with different steps of protein synthesis explored by transcriptional profiling of Escherichia coli K-12
Sabina, Journal of bacteriology 2003 - “...b3774 b1739 b0754 b1897 b2913 b1783 b3433 b0903 b1136 b2215 b0907 b4025 b3956 b4014 b2096 b1004 b2779 b2925 b3510 b0073 0.04 0.05 0.05 0.05 0.06 0.06 0.08 0.09...”
- “...b4191 b0425 b1604 b3509 b3686 b3458 b3668 b3120 b3562 b1045 b0907 b1783 b1596 b3254 b0087 b0726 b3831 b1057 0.02 0.02 0.03 0.03 0.03 0.03 0.03 0.05 0.05 0.06...”
- Comparing the predicted and observed properties of proteins encoded in the genome of Escherichia coli K-12.
Link, Electrophoresis 1997 (PubMed)- GeneRIF: N-terminus verified by Edman degradation on mature peptide
- Evolutionary origin and functional diversification of aminotransferases
Koper, The Journal of biological chemistry 2022 - “...Fig.5 B ). Based on the structure of E.coli phosphoserine AT 1 (SerC or Psat; P23721) ( 141 ) ( Fig.5 ), additional active-site residues, G76 and R77, interact with the phosphate, and W102, C149, T153, and S176 interact with the pyridine ring of PLP (...”
- Knowns and Unknowns of Vitamin B6 Metabolism in Escherichia coli
Tramonti, EcoSal Plus 2021 (secret) - Proteome-level responses of Escherichia coli to long-chain fatty acids and use of fatty acid inducible promoter in protein production
Han, Journal of biomedicine & biotechnology 2008 - “...32 Fba Gel match P11604 5.55/40.6 Fructose-bisphosphate aldolase class II 33 SerC (PdxF) Gel match P23721 5.34/40.2 Phosphoserine aminotransferase 34 SucC Gel match P07460 5.30/42.3 Succinyl-CoA synthetase beta chain 35 LivJ MS/MS P02917 5.28/41.9 Leu/Ile/Val-binding protein 36 Pgk Gel match P11665 5.07/41.9 5.02/41.7 Phosphoglycerate kinase 37...”
- Identification of enzymes and regulatory proteins in Escherichia coli that are oxidized under nitrogen, carbon, or phosphate starvation
Noda, Proceedings of the National Academy of Sciences of the United States of America 2007 - “...P37666 P05793 P0AD97 Q59346 P76558 Q8FB98 P0A7A0 Q8FCA6 P23721 P0AFG8 P0A826 P0A837 P0AC42 P0A9P4 P27302 21165 Protein name Protein MW Protein PI...”
- “...Accession no. P0A9P1 P0A6M9 P0A6Q0 Q59346 P23847 P0A7A0 P23721 P0AD61 P07023 Protein name Protein MW Protein PI Dihydrolipoyl dehydrogenase, 3 Elongation factor...”
- The Escherichia coli proteome: past, present, and future prospects
Han, Microbiology and molecular biology reviews : MMBR 2006 - “...Protein nameb SerC Accession no.b P23721 Descriptionb Phosphoserine aminotransferase pI/MW Theoreticalc 5.37/39,652.12 Experimentald (DIGE 4.5-6.5) (4.5-5.5)...”
- Novel archaeal alanine:glyoxylate aminotransferase from Thermococcus litoralis
Sakuraba, Journal of bacteriology 2004 - “...P07991 P28269 P22256 P17649 P14010 P19938 P00510 P21549 P23721 P19689 P10658 1708172Aa P12995 P22805 Accession number in protein database of NCBI. sus encodes...”
- Engineering Escherichia coli for increased productivity of serine-rich proteins based on proteome profiling
Han, Applied and environmental microbiology 2003 - “...5.55/40.6 30 31 SerC or PdxF SucC Gel match Gel match P23721 P07460 5.34/40.2 5.30/42.3 32 33 LivJ Pgk Gel match Gel match P02917 P11665 34 35 36 MalE LivK RfaD...”
c1045 Phosphoserine aminotransferase from Escherichia coli CFT073
57% identity, 98% coverage
ECs0990 3-phosphoserine aminotransferase from Escherichia coli O157:H7 str. Sakai
Q8XEA7 Phosphoserine aminotransferase from Escherichia coli O157:H7
57% identity, 98% coverage
- The attachment process and physiological properties of Escherichia coli O157:H7 on quartz
Wang, BMC microbiology 2020 - “...glycolysis/glycogenesis was enhanced in attached cells. In addition, the genes Ecs2523 (1.4), Ecs3784 (1.9) and Ecs0990 (1.3) involved in the biosynthesis and degradation of L-serine were upregulated, indicating that the metabolic activity of L-serine was enhanced in attached cells. We confirmed through RT-qPCR experiments that attachment...”
- “...genes pstC , Ecs4664 , Ecs2907 , Ecs2846 , pgk , Ecs2523 , Ecs3784 , Ecs0990 , and yodB (Fig. 3 b and c). Tolerance of environmental stress after E. coli O157:H7 attachment As shown in Table S 6 , the expression levels of the genes...”
- Global transcriptional response of Escherichia coli O157:H7 to growth transitions in glucose minimal medium
Bergholz, BMC microbiology 2007 - “...dmsA -3.37 4 ECs0216 O157 2.02 2 ECs0989 ycaP 2.56 2 ECs0248 fadE 4.57 2 ECs0990 serC -3.29 1 ECs0253 dinJ 2.46 2 ECs0991 aroA -4.24 1 ECs0269 proB -2.11 1 ECs1007 mukB -2.12 1 ECs0383 yahO 4.53 2 ECs1013 asnS -2.74 1 ECs0384 prpR 3.63...”
- Neu-Laxova syndrome is a heterogeneous metabolic disorder caused by defects in enzymes of the L-serine biosynthesis pathway
Acuna-Hidalgo, American journal of human genetics 2014 - “...elegans (UniProt ID P91856), and Escherichia coli (UniProt ID Q8XEA7) were obtained from Uniprot and Entrez. 3D models for human PSAT (PDB ID 3E77 ) and...”
1bjoA / P23721 The structure of phosphoserine aminotransferase from e. Coli in complex with alpha-methyl-l-glutamate (see paper)
57% identity, 99% coverage
- Ligands: pyridoxal-5'-phosphate; alpha-methyl-l-glutamic acid (1bjoA)
A8IH03 Phosphoserine aminotransferase from Chlamydomonas reinhardtii
54% identity, 88% coverage
7t7jB / A6T700 Crystal structure of phosphoserine aminotransferase from klebsiella pneumoniae subsp. Pneumoniae in complex with pyridoxal phosphate
56% identity, 99% coverage
- Ligand: pyridoxal-5'-phosphate (7t7jB)
VC1159 phosphoserine aminotransferase from Vibrio cholerae O1 biovar eltor str. N16961
58% identity, 94% coverage
t1957 phosphoserine aminotransferase from Salmonella enterica subsp. enterica serovar Typhi Ty2
56% identity, 99% coverage
Q63S02 Phosphoserine aminotransferase from Burkholderia pseudomallei (strain K96243)
BPSL2519 phosphoserine aminotransferase from Burkholderia pseudomallei K96243
55% identity, 98% coverage
- Effect of temperature on Burkholderia pseudomallei growth, proteomic changes, motility and resistance to stress environments
Paksanont, Scientific reports 2018 - “...aminotransferase Q63NF6 BPSS0343 phnW phosphonate and phosphinate metabolism 8 101 38917 6.30 Present Phosphoserine aminotransferase Q63S02 BPSL2519 serC glycine, serine and threonine metabolism 9 134 39425 5.94 Present Antioxidants Ferredoxin-NADP(H) reductase Q63YE7 BPSL0241 fpr antioxidant enzyme 10 155 28983 5.78 2.22 Hydroperoxidase reductase Q63T73 BPSL2096 ahpD...”
- Effect of temperature on Burkholderia pseudomallei growth, proteomic changes, motility and resistance to stress environments
Paksanont, Scientific reports 2018 - “...Q63NF6 BPSS0343 phnW phosphonate and phosphinate metabolism 8 101 38917 6.30 Present Phosphoserine aminotransferase Q63S02 BPSL2519 serC glycine, serine and threonine metabolism 9 134 39425 5.94 Present Antioxidants Ferredoxin-NADP(H) reductase Q63YE7 BPSL0241 fpr antioxidant enzyme 10 155 28983 5.78 2.22 Hydroperoxidase reductase Q63T73 BPSL2096 ahpD antioxidant...”
- Interrogation of the Burkholderia pseudomallei genome to address differential virulence among isolates
Challacombe, PloS one 2014 - “...phosphate metabolism, Glycerophospholipid metabolism, Ether lipid metabolism BPSL2433 peptidase; Do family protease; serine protease various BPSL2519 phosphoserine aminotransferase (EC 2.6.1.52)# Glycine, serine and threonine metabolism, Methane metabolism, Vitamin B6 metabolism BPSL2672 epimerase/dehydratase capsule polysaccharide biosynthesis protein various BPSL2673 undecaprenyl phosphate N-acetylglucosaminyltransferase; glycoside hydrolase family protein; UDP-D-N-acetylhexosamine:polyprenol...”
PMI_RS03500 3-phosphoserine/phosphohydroxythreonine transaminase from Proteus mirabilis HI4320
PMI0711 phosphoserine aminotransferase from Proteus mirabilis HI4320
55% identity, 99% coverage
- Organ agar serves as physiologically relevant alternative for in vivo bacterial colonization
Pearson, Infection and immunity 2023 - “...e Y PMI0641 sanA PMI_RS03160 215 C10 0.854 K Putative transport protein Y PMI0711 serC PMI_RS03500 219 C4 0.419 UK Phosphoserine aminotransferase Amino acid metabolism Y PMI0765 ompF/ nmpC PMI_RS03760 218 G6 0.716 UK Outer membrane porin Signal transduction Y PMI1151 znuC PMI_RS05555 201 G4 0.775...”
- Organ agar serves as physiologically relevant alternative for in vivo bacterial colonization
Pearson, Infection and immunity 2023 - “...TCA cycle e Y PMI0641 sanA PMI_RS03160 215 C10 0.854 K Putative transport protein Y PMI0711 serC PMI_RS03500 219 C4 0.419 UK Phosphoserine aminotransferase Amino acid metabolism Y PMI0765 ompF/ nmpC PMI_RS03760 218 G6 0.716 UK Outer membrane porin Signal transduction Y PMI1151 znuC PMI_RS05555 201...”
- “...Dihydrolipoamide succinyltransferase component of 2-oxoglutarate dehydrogenase complex PMI0641 sanA K KS US Putative transport protein PMI0711 serC UK KS UBKS Phosphoserine aminotransferase PMI1545 guaA UKL UKLBS UK GMP synthase (glutamine-hydrolyzing) PMI2870 UKL None d UBKS Hypothetical protein PMI3210 glpK U None US Glycerol kinase PMI3457 argI...”
- Pathogenesis of <i>Proteus mirabilis</i> Infection
Armbruster, EcoSal Plus 2018 (secret) - Proteus mirabilis and Urinary Tract Infections
Schaffer, Microbiology spectrum 2015 - “...134 ) tpiA PMI3205 triosephosphate isomerase NR cr NR ( 134 ) Amino acids serC PMI0711 phosphoserine aminotransferase NR cr NR ( 56 ) cysJ PMI2250 sulfite reductase [NADPH] flavoprotein alpha-component NR cr c + ( 65 ) dppA PMI2847 dipeptide ABC transporter, substrate-binding protein NR...”
RS_RS04490 3-phosphoserine/phosphohydroxythreonine transaminase from Ralstonia pseudosolanacearum GMI1000
54% identity, 94% coverage
- A Comprehensive Overview of the Genes and Functions Required for Lettuce Infection by the Hemibiotrophic Phytopathogen Xanthomonas hortorum pv. vitians
Morinière, mSystems 2022 - “...XHV734_3365 aroA 3-Phosphoshikimate 1-carboxyvinyltransferase RS_RS04510 XHV734_3366 pheA Chorismate mutase/prephenate dehydratase ATU_RS00480 XHV734_3367 serC 3-Phosphoserine/phosphohydroxythreonine aminotransferase RS_RS04490 XHV734_3398 metXS Homoserine O -succinyltransferase Psyr_0474 XHV734_3771 clpX ATPase and specificity subunit of ClpX-ClpP ATP-dependent serine protease Psyr_1748 RS_RS08650 XHV734_3772 clpP Proteolytic subunit of ClpA-ClpP and ClpX-ClpP ATP-dependent serine protease...”
- Genome-Wide Identification of Ralstonia solanacearum Genes Required for Survival in Tomato Plants
Su, mSystems 2021 - “...membrane protein RS_RS04475 severely decreased the in planta fitness of R. solanacearum . RS_RS09970 and RS_RS04490 are involved in tryptophan and serine biosynthesis, respectively. Mutants that lack RS_RS09970 or RS_RS04490 did not cause any wilt symptoms in susceptible tomato plants. These results confirmed the importance of...”
- “...( Fig.S2 ). In addition, genes involved in the biosynthesis of serine ( RS_RS08265 and RS_RS04490 ), cysteine ( RS_RS05790 ), methionine ( RS_RS00135 ), and lysine ( RS_RS05700 ) were also identified as essential for the survival of R. solanacearum in tomato plants. 10.1128/mSystems.00838-21.4 FIGS2...”
PSAT / Q96255 phosphoserine aminotransferase (EC 2.6.1.52) from Arabidopsis thaliana (see paper)
SERB1_ARATH / Q96255 Phosphoserine aminotransferase 1, chloroplastic; AtPSAT1; Phosphohydroxythreonine aminotransferase; EC 2.6.1.52 from Arabidopsis thaliana (Mouse-ear cress) (see 4 papers)
Q96255 phosphoserine transaminase (EC 2.6.1.52) from Arabidopsis thaliana (see 3 papers)
AT4G35630 PSAT; O-phospho-L-serine:2-oxoglutarate aminotransferase from Arabidopsis thaliana
52% identity, 83% coverage
- function: Involved in the plastidial phosphorylated pathway of serine biosynthesis (PPSB). Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine.
catalytic activity: O-phospho-L-serine + 2-oxoglutarate = 3-phosphooxypyruvate + L-glutamate (RHEA:14329)
catalytic activity: 4-(phosphooxy)-L-threonine + 2-oxoglutarate = (R)-3-hydroxy-2- oxo-4-phosphooxybutanoate + L-glutamate (RHEA:16573)
cofactor: pyridoxal 5'-phosphate (Binds 1 pyridoxal phosphate per subunit.)
subunit: Homodimer. - Metabolic engineering of the serine/glycine network as a means to improve the nitrogen content of crops
Casatejada-Anchel, Plant biotechnology journal 2025 - “...At TriOex lines overexpressing the three main PPSB genes ( AtPGDH1 , At4g34200; AtPSAT1 , At4g35630; and AtPSP1 , At1g18640), transgenic plants overexpressing the AtPGDH1 gene (Toujani etal ., 2013 ) were used as a starting material. Two constructs were obtained in order to cooverexpress AtPSAT1...”
- “...numbers The Arabidopsis locus identifiers for genes used in this study are: PGDH1 (At4g34200); PSAT1 (At4g35630); PSP1 (At1g18640). Themaize locus identifiers for PGDH1 genes are: ZmPGDHX1 (Zm00001d032114); ZmPGDHX2 (Zm00001d046923); ZmPGDHX9 (Zm00001d002051) and PGDHX10 (Zm00001d026472). Author contributions RCA, ATM, ADA, NB, AAE, LPS, SRT, JK, EPL and...”
- Overexpression of Phosphoserine Aminotransferase (PSAT)-Enhanced Cadmium Resistance and Accumulation in Duckweed (Lemna turionifera 5511)
Ma, Plants (Basel, Switzerland) 2024 - “...from the plants and subjected to specific PCR amplification targeting the PSAT gene (AGI number AT4G35630) for identification purposes. Notably, PSAT was not amplified in the negative control or the wild-type (WT) plants. These results confirmed the successful transformation of all five transgenic strains ( Figure...”
- Gel-based proteomic map of Arabidopsis thaliana root plastids and mitochondria
Grabsztunowicz, BMC plant biology 2020 - “...36, 37 Q05758, At3g58610 Ornithine carbamoyltransferase 85 O50039, At1g75330 Phosphoserine aminotransferase 1 64, 66 Q96255, At4g35630 Phosphoserine aminotransferase 2 66 Q9SHP0, At2g17630 Probable N-acetyl-gamma-glutamyl-phosphate reductase 70, 71 Q93Z70, At2g19940 Threonine synthase 1 4850 Q9S7B5, At4g29840 Tryptophan synthase beta chain 1 65 P14671, At5g54810 Regulation ACT domain-containing...”
- “...PSAT isoforms encoded by the Arabidopsis genomes were both detected in our experiment, PSAT 1 (At4g35630) in spots 64 and 66 and PSAT 2 (At2g17630) in spot 66. Additionally, plastidial cysteine synthase (CS, At2g43750), catalyzing conversion of O-acetylserine and sulfide to L-cysteine and acetate, was found...”
- Overexpression of Jatropha curcas ERFVII2 Transcription Factor Confers Low Oxygen Tolerance in Transgenic Arabidopsis by Modulating Expression of Metabolic Enzymes and Multiple Stress-Responsive Genes
Juntawong, Plants (Basel, Switzerland) 2020 - “...glutamine synthase ( GSR1 ); AT5G38200 : Class I glutamine amidotransferase-like superfamily protein , and AT4G35630 : phosphoserine aminotransferase ; Supplementary Materials Table S1 ), implying the possibility that the transgenic Arabidopsis lines overexpressing MA-JcERFVII2 could face carbohydrate starvation that leads to reduced growth and development....”
- Functional characterization of genes mediating cell wall metabolism and responses to plant cell wall integrity impairment
Engelsdorf, BMC plant biology 2019 - “...UGT76B1 , [ 67 ]), At4g33420 ( PEROXIDASE 47 , PRX47 , [ 68 ]), At4g35630 ( PHOSPHOSERINE AMINO-TRANSFERASE 1 , PSAT 1 , [ 69 ]), At5g48460 ( FIMBRIN 2, ATFIM2, [ 70 ]), At5g47730 ( SEC14-HOMOLOGUE 19 , SFH19 , [ 56 , 71...”
- Phosphoserine Aminotransferase1 Is Part of the Phosphorylated Pathways for Serine Biosynthesis and Essential for Light and Sugar-Dependent Growth Promotion
Wulfert, Frontiers in plant science 2018 - “...; At1g17745 , PGDH2 ; At3g19480 , PGDH3 ), two genes for the PSAT ( At4g35630 , PSAT1 , and At2g17630 , PSAT2 ) and one gene for the PSP ( At1g18640 ). Deficiency in either the PGDH1 , or the PSP gene causes embryo lethality...”
- “...aminotransferases. Results Identification and Expression Patterns of PSAT Genes in Arabidopsis thaliana Two genes, PSAT1 (At4g35630) and PSAT2 (At2g17630) with a high similarity to the SERC gene from Escherichia coli , the CCDS6659 gene from Homo sapiens and the YOR184W gene from Saccharomyces cerevisiae were identified...”
- Identification and Biochemical Characterization of the Serine Biosynthetic Enzyme 3-Phosphoglycerate Dehydrogenase in Marchantia polymorpha
Akashi, Frontiers in plant science 2018 - “...Homology Search for Serine Biosynthetic Genes and Multiple Alignments The homologs of AtPGDH1 (At4g34200), AtPSAT1 (At4g35630), and AtPSP (At1g18640) in Physcomitrella patens were searched using blastp. Then, the top hit sequence of respective genes (PHYPADRAFT_122014, PHYPADRAFT_129784, and PHYPADRAFT_13475) was used as a query for a tblastn...”
- High serine:glyoxylate aminotransferase activity lowers leaf daytime serine levels, inducing the phosphoserine pathway in Arabidopsis
Modde, Journal of experimental botany 2017 - “...(GDC-T), At4g33010 (GDC-P), At4g37930 (SHM1), At1g68010 (HPR1), At1g80380 (GLYK), At5g40760 (cG6PD), At5g36700 (PGLP), At1g18640 (PSP), At4g35630 (PSAT), At1g17745 (PGDH), and At2g09990 (40S ribosomal protein S16). Results Overexpression lines and SGAT activities For SGAT overexpression in Arabidopsis, we used a Flaveria pringlei SGAT ( FpSGAT ) cDNA...”
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- Sexual and Apogamous Species of Woodferns Show Different Protein and Phytohormone Profiles
Fernández, Frontiers in plant science 2021 - “...814 681-1862_1_ORF2 58 Q9SMT7 0 1 4.3 2 Phosphoserine aminotransferase 1, chloroplastic 647 350227-43_2_ORF2 46 Q96255 0 1.74 12 4 Embryo defective 2171 (emb2171) 76 18818-572_2_ORF2 (+3) 16 P49690 1.51032E-96 1.32 17 3 RNA-binding (RRM/RBD/RNP motifs) family protein (LIF2) 873 71037-299_5_ORF2 63 Q9ASP6 1.00527E-36 1.32 7.2...”
- Gel-based proteomic map of Arabidopsis thaliana root plastids and mitochondria
Grabsztunowicz, BMC plant biology 2020 - “...reductoisomerase 36, 37 Q05758, At3g58610 Ornithine carbamoyltransferase 85 O50039, At1g75330 Phosphoserine aminotransferase 1 64, 66 Q96255, At4g35630 Phosphoserine aminotransferase 2 66 Q9SHP0, At2g17630 Probable N-acetyl-gamma-glutamyl-phosphate reductase 70, 71 Q93Z70, At2g19940 Threonine synthase 1 4850 Q9S7B5, At4g29840 Tryptophan synthase beta chain 1 65 P14671, At5g54810 Regulation ACT...”
- The rolB plant oncogene affects multiple signaling protein modules related to hormone signaling and plant defense
Bulgakov, Scientific reports 2018 - “...Protein peptidyl-prolyl isomerization NAD(P)H dehydrogenase complex assembly 3.40.4 Chaperone Modulates the conformation of BZR1 9 Q96255 (SERB1_ARATH) Phosphoserine aminotransferase 1, chloroplastic Amino-acid biosynthesis 8.91.0 Primary metabolism 10 Q93ZC5 (AOC4_ARATH) Allene oxide cyclase 4, chloroplastic Jasmonic acid biosynthetic process 5.40.5 11 O49485 (SERA1_ARATH) D-3-phosphoglycerate dehydrogenase 1, chloroplastic...”
RSUY_11010 3-phosphoserine/phosphohydroxythreonine transaminase from Ralstonia solanacearum
54% identity, 94% coverage
6czyA / Q96255 Crystal structure of arabidopsis thaliana phosphoserine aminotransferase isoform 1 (atpsat1) in complex with pyridoxamine-5'- phosphate (pmp) (see paper)
52% identity, 99% coverage
- Ligand: 4'-deoxy-4'-aminopyridoxal-5'-phosphate (6czyA)
B9H657 Phosphoserine aminotransferase from Populus trichocarpa
53% identity, 85% coverage
Rmet_0715 phosphoserine aminotransferase from Ralstonia metallidurans CH34
Rmet_0715 3-phosphoserine/phosphohydroxythreonine transaminase from Cupriavidus metallidurans CH34
53% identity, 93% coverage
- The complete genome sequence of Cupriavidus metallidurans strain CH34, a master survivalist in harsh and anthropogenic environments
Janssen, PloS one 2010 - “...proceeds via two complementary pathways. The biosynthetic pathway involves the genes pdxC ( serC ; Rmet_0715), pdxA (present in two copies Rmet_0438, Rmet_2590), a gene encoding an FMN-binding protein (Rmet_0820), pdxJ (Rmet_2415), dxs (Rmet_2615; also involved in VitB1 synthesis, see above), pdxH (Rmet_2642), and a putative...”
6xdkD / B2FKF0 Crystal structure of phosphoserine aminotransferase (serc) from stenotrophomonas maltophilia k279a
53% identity, 99% coverage
- Ligand: pyridoxal-5'-phosphate (6xdkD)
SERB2_ARATH / Q9SHP0 Phosphoserine aminotransferase 2, chloroplastic; AtPSAT2; EC 2.6.1.52 from Arabidopsis thaliana (Mouse-ear cress) (see paper)
Q9SHP0 phosphoserine transaminase (EC 2.6.1.52) from Arabidopsis thaliana (see paper)
AT2G17630 phosphoserine aminotransferase, putative from Arabidopsis thaliana
52% identity, 85% coverage
- function: Involved in the plastidial phosphorylated pathway of serine biosynthesis (PPSB). Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine.
catalytic activity: O-phospho-L-serine + 2-oxoglutarate = 3-phosphooxypyruvate + L-glutamate (RHEA:14329)
catalytic activity: 4-(phosphooxy)-L-threonine + 2-oxoglutarate = (R)-3-hydroxy-2- oxo-4-phosphooxybutanoate + L-glutamate (RHEA:16573)
cofactor: pyridoxal 5'-phosphate - Gel-based proteomic map of Arabidopsis thaliana root plastids and mitochondria
Grabsztunowicz, BMC plant biology 2020 - “...carbamoyltransferase 85 O50039, At1g75330 Phosphoserine aminotransferase 1 64, 66 Q96255, At4g35630 Phosphoserine aminotransferase 2 66 Q9SHP0, At2g17630 Probable N-acetyl-gamma-glutamyl-phosphate reductase 70, 71 Q93Z70, At2g19940 Threonine synthase 1 4850 Q9S7B5, At4g29840 Tryptophan synthase beta chain 1 65 P14671, At5g54810 Regulation ACT domain-containing protein 88 Q9LZ23, AT5G04740 CARBOHYDRATE...”
- Gel-based proteomic map of Arabidopsis thaliana root plastids and mitochondria
Grabsztunowicz, BMC plant biology 2020 - “...85 O50039, At1g75330 Phosphoserine aminotransferase 1 64, 66 Q96255, At4g35630 Phosphoserine aminotransferase 2 66 Q9SHP0, At2g17630 Probable N-acetyl-gamma-glutamyl-phosphate reductase 70, 71 Q93Z70, At2g19940 Threonine synthase 1 4850 Q9S7B5, At4g29840 Tryptophan synthase beta chain 1 65 P14671, At5g54810 Regulation ACT domain-containing protein 88 Q9LZ23, AT5G04740 CARBOHYDRATE METABOLISM...”
- “...detected in our experiment, PSAT 1 (At4g35630) in spots 64 and 66 and PSAT 2 (At2g17630) in spot 66. Additionally, plastidial cysteine synthase (CS, At2g43750), catalyzing conversion of O-acetylserine and sulfide to L-cysteine and acetate, was found in spots 82, 83 and 102. ATP- phosphoribosyltransferase (ATP-PRT,...”
- Proteomic and metabolomic analyses provide insight into the off-flavour of fruits from citrus trees infected with 'Candidatus Liberibacter asiaticus'
Yao, Horticulture research 2019 - “...EC 1.1.1.85 0.66 3.20E03 gi|568825237 AT5G66120 K2A18.20 Putative 3-dehydroquinate synthase EC 4.2.3.4 0.55 2.42E04 gi|568825398 AT2G17630 PSAT2 Pyridoxal phosphate-dependent transferase EC 2.6.1.52 0.66 2.54E02 gi|568867337 AT1G49820 MTK 5-Methylthioribose kinase EC 2.7.1.100 0.63 7.61E03 gi|568875049 AT5G52810 SARD4 NAD(P)-binding Rossmann-fold superfamily protein EC 4.3.1.12 0.56 4.07E02 gi|568876134 AT3G61440...”
- Phosphoserine Aminotransferase1 Is Part of the Phosphorylated Pathways for Serine Biosynthesis and Essential for Light and Sugar-Dependent Growth Promotion
Wulfert, Frontiers in plant science 2018 - “...At3g19480 , PGDH3 ), two genes for the PSAT ( At4g35630 , PSAT1 , and At2g17630 , PSAT2 ) and one gene for the PSP ( At1g18640 ). Deficiency in either the PGDH1 , or the PSP gene causes embryo lethality and male sterility and plants...”
- “...and Expression Patterns of PSAT Genes in Arabidopsis thaliana Two genes, PSAT1 (At4g35630) and PSAT2 (At2g17630) with a high similarity to the SERC gene from Escherichia coli , the CCDS6659 gene from Homo sapiens and the YOR184W gene from Saccharomyces cerevisiae were identified in the Arabidopsis...”
- DYn-2 Based Identification of Arabidopsis Sulfenomes
Akter, Molecular & cellular proteomics : MCP 2015 - “...AT1G63940 AT4G16155 AT1G12900 AT5G65430 AT3G56940 AT2G17630 AT1G80270 AT5G65620 AT3G58140 AT1G79530 AT5G49910 AT1G36280 AT1G22940 AT1G63770 AT5G15450 AT1G43800...”
- DNA methylation in Arabidopsis has a genetic basis and shows evidence of local adaptation
Dubin, eLife 2015 - “...3.50E-05 2_6998631 AT2G16340 Unknown protein 1.35E-08 2_6998631 AT2G16210 Transcriptional factor B3 family protein 1.69E-04 2_7666059 AT2G17630 Pyridoxal phosphate (PLP)-dependent transferases superfamily protein 2.47E-18 2_7660469 AT2G17620 Cyclin B2;1 (CYCB2;1) 9.68E-07 2_7655016 AT2G17740 Cysteine/Histidine-rich C1 domain family protein 1.22E-04 2_7655016 AT2G17420 NADPH-DEPENDENT THIOREDOXIN REDUCTASE 2 (NTR2) 9.96E-04 2_7666059...”
- Translation initiation factor AteIF(iso)4E is involved in selective mRNA translation in Arabidopsis thaliana seedlings
Martínez-Silva, PloS one 2012 - “...2.9 Decrease At1g21630 Calcium ion binding, EF hand protein 0.64 3.5 2.6 3.2 1.5 Decrease At2g17630 Pyridoxal phosphate (PLP)-dependent transferase 1.25 2.5 2.2 2.8 1.4 Decrease At1g78240 Tumorous shoot development 2 ( TSD2 ) 0.88 1.6 1.6 1.5 1.0 Decrease At2g27940 RING/U-box protein 0.04 1.98 1.8...”
SERC_NIACI / Q59196 Phosphoserine aminotransferase; Phosphohydroxythreonine aminotransferase; PSAT; EC 2.6.1.52 from Niallia circulans (Bacillus circulans) (see 2 papers)
Q59196 phosphoserine transaminase (EC 2.6.1.52) from Niallia circulans (see paper)
serC / CAA86558.2 phosphoserine aminotransferase from Bacillus circulans subsp. alkalophilus (see paper)
52% identity, 100% coverage
- function: Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine.
catalytic activity: O-phospho-L-serine + 2-oxoglutarate = 3-phosphooxypyruvate + L-glutamate (RHEA:14329)
catalytic activity: 4-(phosphooxy)-L-threonine + 2-oxoglutarate = (R)-3-hydroxy-2- oxo-4-phosphooxybutanoate + L-glutamate (RHEA:16573)
cofactor: pyridoxal 5'-phosphate (Binds 1 pyridoxal phosphate per subunit. {ECO:0000269|PubMed:16532449, ECO:0000269|Ref.)4}
subunit: Homodimer.
LOC100795286 phosphoserine aminotransferase 2, chloroplastic from Glycine max
52% identity, 84% coverage
SERC_SPIOL / P52877 Phosphoserine aminotransferase, chloroplastic; PSAT; Phosphohydroxythreonine aminotransferase; EC 2.6.1.52 from Spinacia oleracea (Spinach) (see paper)
55% identity, 83% coverage
- function: Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine.
catalytic activity: O-phospho-L-serine + 2-oxoglutarate = 3-phosphooxypyruvate + L-glutamate (RHEA:14329)
catalytic activity: 4-(phosphooxy)-L-threonine + 2-oxoglutarate = (R)-3-hydroxy-2- oxo-4-phosphooxybutanoate + L-glutamate (RHEA:16573)
cofactor: pyridoxal 5'-phosphate (Binds 1 pyridoxal phosphate per subunit.)
subunit: Homodimer. - Proteomic analysis of peach fruit mesocarp softening and chilling injury using difference gel electrophoresis (DIGE)
Nilo, BMC genomics 2010 - “...147 8.8 0 -1 -1 -1 -1 0 N209 Phosphoserine aminotransferase, chloroplast precursor [Spinacia oleracea] P52877 8.3/7.7 47.2/47.6 231 11.2 0 0 -1 0 -1 -1 N222 Quinone-oxidoreductase QR1 [Triphysaria versicolor] AAG53944 9.4/8.2 34.9/46.1 158 9.4 1 1 1 0 0 0 N228 Catalase [Prunus persica]...”
1bt4A / Q59196 Phosphoserine aminotransferase from bacillus circulans subsp. Alkalophilus
52% identity, 100% coverage
- Ligand: pyridoxal-5'-phosphate (1bt4A)
LOC105211328 probable phosphoserine aminotransferase from Zeugodacus cucurbitae
52% identity, 97% coverage
- Identification of testis development-related genes by combining Iso-Seq and RNA-Seq in Zeugodacus tau
Liu, Frontiers in cell and developmental biology 2024 - “...PNPO LOC105219330 4.915588 10.87719 9.781125 * * PDXK LOC105220897 4.831618 11.59752 11.2213 * * PSAT LOC105211328 12.84718 8.159183 3.695703 no * Ascorbate and aldarate metabolism UGT LOC128919756 8.726864 5.028652 0.848712 * * LOC105209919 12.46673 21.09953 26.58083 no * LOC105210436 0.416249 1.227206 1.176597 no * LOC105210791 2.563174...”
- “...PDXK (LOC105220897) and one PNPO (LOC105219330) was significantly increased and plateaued. Additionally, one PSAT gene (LOC105211328) was continuously downregulated ( Table 2 ). Therefore, these vitamin B6 metabolism-associated DEGs with specific expression patterns were highly likely to be involved in testis development. Ascorbate and aldarate metabolism...”
G7L9H1 Phosphoserine aminotransferase from Medicago truncatula
52% identity, 84% coverage
- Ultrastructural and Photosynthetic Responses of Pod Walls in Alfalfa to Drought Stress
Wang, International journal of molecular sciences 2020 - “...0.4 G7JJ96 Aminomethyltransferase NS NS 0.3 G7JNS2 NAD-dependent aldehyde dehydrogenase family protein NS NS 0.4 G7L9H1 Phosphoserine aminotransferase NS NS 0.3 Linoleic acid metabolism A0A072UMH4 Lipoxygenase 0.5 NS NS G7J629 Lipoxygenase 0.4 NS NS G7LIX7 Lipoxygenase 5.0 NS NS G7LIY0 Lipoxygenase 5.0 NS 0.4 G7LIY2 Lipoxygenase...”
LOC412670 probable phosphoserine aminotransferase from Apis mellifera
50% identity, 96% coverage
- Long-Distance Transportation Causes Temperature Stress in the Honey Bee, Apis mellifera (Hymenoptera: Apidae)
Melicher, Environmental entomology 2019 - “...Biosynthesis of antibiotics Kynurenine/alpha-aminoadipate aminotransferase LOC724239 2.726 Multifunctional protein ADE2 LOC551966 0.794 Probable phosphoserine aminotransferase LOC412670 0.752 Tyrosine aminotransferase LOC725204 0.788 Defense/venom component Hyaluronoglucosaminidase LOC406146 1.477 Secapin LOC406145 2.752 Venom allergen Api m 6 LOC678674 2.081 Venom carboxylesterase-6 Est-6 1.499 Phospholipase A2 Pla2 4.462 Stress response...”
F7H2J8 Phosphoserine aminotransferase from Macaca mulatta
50% identity, 97% coverage
A6QR28 Phosphoserine aminotransferase from Bos taurus
51% identity, 96% coverage
8a5vE / Q9Y617 Crystal structure of the human phosposerine aminotransferase (psat) (see paper)
50% identity, 98% coverage
- Ligand: sulfate ion (8a5vE)
Q71VT6 Phosphoserine aminotransferase from Listeria monocytogenes serotype 4b (strain F2365)
53% identity, 98% coverage
PSAT1 / Q9Y617 Phosphoserine aminotransferase (EC 2.6.1.52) from Homo sapiens (see 2 papers)
SERC_HUMAN / Q9Y617 Phosphoserine aminotransferase; Phosphohydroxythreonine aminotransferase; PSAT; EC 2.6.1.52 from Homo sapiens (Human) (see 7 papers)
Q9Y617 glycine transaminase (EC 2.6.1.4); phosphoserine transaminase (EC 2.6.1.52) from Homo sapiens (see 5 papers)
NP_478059 phosphoserine aminotransferase isoform 1 from Homo sapiens
50% identity, 97% coverage
- function: Involved in L-serine biosynthesis via the phosphorylated pathway, a three-step pathway converting the glycolytic intermediate 3- phospho-D-glycerate into L-serine. Catalyzes the second step, that is the pyridoxal 5'-phosphate-dependent transamination of 3- phosphohydroxypyruvate and L-glutamate to O-phosphoserine (OPS) and alpha-ketoglutarate.
catalytic activity: O-phospho-L-serine + 2-oxoglutarate = 3-phosphooxypyruvate + L-glutamate (RHEA:14329)
cofactor: pyridoxal 5'-phosphate (Binds 2 pyridoxal phosphate molecules per dimer, each cofactor is bound at the monomer-monomer interface and forms contacts with residues from both chains. {ECO:0000269|PubMed:36851825, ECO:0000269|Ref.)11}
subunit: Homodimer. - PSAT1 promotes autophagy to resist insufficient autophagy caused by cigarette smoke extract in human airway epithelial cells.
Wang, Toxicology in vitro : an international journal published in association with BIBRA 2024 (PubMed)- GeneRIF: PSAT1 promotes autophagy to resist insufficient autophagy caused by cigarette smoke extract in human airway epithelial cells.
- Upregulation of serine metabolism enzyme PSAT1 predicts poor prognosis and promotes proliferation, metastasis and drug resistance of clear cell renal cell carcinoma.
Ye, Experimental cell research 2024 (PubMed)- GeneRIF: Upregulation of serine metabolism enzyme PSAT1 predicts poor prognosis and promotes proliferation, metastasis and drug resistance of clear cell renal cell carcinoma.
- PSAT1 Promotes Metastasis via p-AKT/SP1/ITGA2 Axis in Estrogen Receptor-Negative Breast Cancer Cell.
Zhang, Biomolecules 2024 - GeneRIF: PSAT1 Promotes Metastasis via p-AKT/SP1/ITGA2 Axis in Estrogen Receptor-Negative Breast Cancer Cell.
- PSAT1 is upregulated by METTL3 to attenuate high glucose-induced retinal pigment epithelial cell apoptosis and oxidative stress.
Du, Diagnostic pathology 2024 - GeneRIF: PSAT1 is upregulated by METTL3 to attenuate high glucose-induced retinal pigment epithelial cell apoptosis and oxidative stress.
- Interplay between acetylation and ubiquitination controls PSAT1 protein stability in lung adenocarcinoma.
Liu, Communications biology 2024 - GeneRIF: Interplay between acetylation and ubiquitination controls PSAT1 protein stability in lung adenocarcinoma.
- miRNA-195-5p/PSAT1 feedback loop in human triple-negative breast cancer cells.
Wang, Genes & genomics 2023 (PubMed)- GeneRIF: miRNA-195-5p/PSAT1 feedback loop in human triple-negative breast cancer cells.
- Pathogenic PSAT1 Variants and Autosomal Recessive Axonal Charcot-Marie-Tooth Disease With Ichthyosis.
Lu, Pediatric neurology 2023 (PubMed)- GeneRIF: Pathogenic PSAT1 Variants and Autosomal Recessive Axonal Charcot-Marie-Tooth Disease With Ichthyosis.
- Targeting PSAT1 to mitigate metastasis in tumors with p53-72Pro variant.
Jiang, Signal transduction and targeted therapy 2023 - GeneRIF: Targeting PSAT1 to mitigate metastasis in tumors with p53-72Pro variant.
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- Characterization and Proteomic Profiling of Hepatocyte-like Cells Derived from Human Wharton's Jelly Mesenchymal Stromal Cells: De Novo Expression of Liver-Specific Enzymes
Lo, Biology 2025 (no snippet) - Proteomic Profiling of Endothelial Cell Secretomes After Exposure to Calciprotein Particles Reveals Downregulation of Basement Membrane Assembly and Increased Release of Soluble CD59.
Stepanov, International journal of molecular sciences 2024 - “...N/A N/A 3/8 ACTB P60709 2.64 N/A 2.69 N/A N/A N/A N/A N/A 2/8 PSAT1 Q9Y617 1.99 N/A 2.43 N/A N/A N/A N/A N/A 2/8 ALCAM Q13740 1.75 N/A 1.63 N/A N/A N/A N/A N/A 2/8 CAV1 Q03135 1.65 2.35 N/A N/A N/A N/A N/A N/A...”
- Polymorphism Pro64His within galectin-3 has functional consequences at proteome level in thyroid cells.
Silvestri, Frontiers in genetics 2024 - “...43.35 1.7 1,085 P04075 ALDOA 28 9 39,420 8.39 0.002 3.5 448.21 156.31 2.9 1,131 Q9Y617 PSAT1 20 7 40,423 7.56 2.59E-04 5.1 196.95 564.65 0.3 1,131 P11766 ADH5 5 2 39,724 7.45 2.59E-04 5.1 84.44 64.88 1.3 1,134 Q00796 SORD 20 5 38,325 8.25 0.019...”
- Analysis of the mechanism of curcumin against osteoarthritis using metabolomics and transcriptomics.
Deng, Naunyn-Schmiedeberg's archives of pharmacology 2024 - “...oxidase 4 CTH P32929 Cystathionine gamma-lyase 5 MAOA P21397 Amine oxidase [flavin-containing] A 6 PSAT1 Q9Y617 Phosphoserine aminotransferase 7 CDO1 Q16878 Cysteine dioxygenase type 1 8 DCXR Q7Z4W1 L-xylulose reductase 9 DGAT2 Q96PD7 Diacylglycerol O-acyltransferase 2 10 DHDH Q9UQ10 Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase 11 GALNT15 Q8N3T1 Polypeptide N-acetylgalactosaminyltransferase...”
- Sequence similarity between SARS-CoV-2 nucleocapsid and multiple sclerosis-associated proteins provides insight into viral neuropathogenesis following infection
Lake, Scientific reports 2023 - “...sapiens (Human) Q9Y6M0 Testisin PRSS21 Homo sapiens (Human) P63313 Thymosin beta-10 TMSB10 Homo sapiens (Human) Q9Y617 Phosphoserine aminotransferase PSAT1 Homo sapiens (Human) Q01082 Spectrin beta chain, non-erythrocytic 1 SPTBN1 SPTB2 Homo sapiens (Human) Q6ZMD2 Protein spinster homolog 3 SPNS3 Homo sapiens (Human) Q8IUQ4 E3 ubiquitin-protein ligase...”
- The mitotic surveillance pathway requires PLK1-dependent 53BP1 displacement from kinetochores
Burigotto, 2023 - Highlighting In Vitro the Role of Brain-like Endothelial Cells on the Maturation and Metabolism of Brain Pericytes by SWATH Proteomics.
Menaceur, Cells 2023 - “...0.257 Q01995 TAGLN Transgelin 7.03 0.979 P24844 MYL9 Myosin regulatory light polypeptide 9 4.67 0.737 Q9Y617 PSAT1 Phosphoserine aminotransferase 4.19 0.098 P15924 DSP Desmoplakin 3.62 0.07 P09493 TPM1 Tropomyosin alpha-1 chain 3.57 1.12 P42566 EPS15 Epidermal growth factor receptor substrate 15 3.51 0.814 Q05682 CALD1 Caldesmon...”
- Caffeine causes cell cycle arrest at G0/G1 and increases of ubiquitinated proteins, ATP and mitochondrial membrane potential in renal cells.
Kanlaya, Computational and structural biotechnology journal 2023 - “...0.51 0.0020 Peroxiredoxin-1 Q06830 PRDX1 179.8 53.3 12/16 22.1 225.3315.55 163.6512.16 0.73 0.0065 Phosphoserine aminotransferase Q9Y617 PSAT1 57.6 21.4 6/7 40.4 19.601.47 14.261.27 0.73 0.0142 Poly(rC)-binding protein 2 Q61990 Pcbp2 45.3 23.5 5/7 38.2 48.881.68 35.194.72 0.72 0.0147 Poly(U)-binding-splicing factor PUF60 Q2HJG2 PUF60 65.0 10.4 3/3...”
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Q80YG1 Phosphoserine aminotransferase from Rattus norvegicus
50% identity, 97% coverage
SERC_DROME / Q9VAN0 Phosphoserine aminotransferase; Phosphohydroxythreonine aminotransferase; EC 2.6.1.52 from Drosophila melanogaster (Fruit fly) (see paper)
CG11899 uncharacterized protein from Drosophila melanogaster
51% identity, 98% coverage
- function: Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine.
catalytic activity: O-phospho-L-serine + 2-oxoglutarate = 3-phosphooxypyruvate + L-glutamate (RHEA:14329)
catalytic activity: 4-(phosphooxy)-L-threonine + 2-oxoglutarate = (R)-3-hydroxy-2- oxo-4-phosphooxybutanoate + L-glutamate (RHEA:16573)
cofactor: pyridoxal 5'-phosphate (Binds 1 pyridoxal phosphate per subunit.)
subunit: Homodimer. - Global stable-isotope tracing metabolomics reveals system-wide metabolic alternations in aging Drosophila
Wang, Nature communications 2022 - “...3-phosphoglycerate (3-PG), thereby supporting serine biosynthesis. We found that two genes involved in serine biosynthesis, CG11899 and CG6287 , were significantly increased in 30d Drosophila . Higher levels of shmt in old Drosophila heads were also observed. In addition, genes responsible for purine metabolism, including Pfas...”
- The Phosphoserine Phosphatase Alters the Free Amino Acid Compositions and Fecundity in Cyrtorhinus lividipennis Reuter
Ahmad, International journal of molecular sciences 2022 - “...1-pyrroline-5-carboxylate synthase (CG9018) accession: FBgn0035318, alanine-glyoxylate aminotransferase (Spat) accession: FBgn0014031, phosphoglycerate dehydrogenase (CG6287) accession: FBgn0032350, (CG11899) accession: FBgn0014427, serine racemase (CG8129) accession: FBgn0037684. Figure 5 Temporal and development variations of PSP expression in the mentioned life stages. ( A ) represents the PSP expression in developmental...”
- Crtc modulates fasting programs associated with 1-C metabolism and inhibition of insulin signaling
Wang, Proceedings of the National Academy of Sciences of the United States of America 2021 (secret) - Ade2 Functions in the Drosophila Fat Body To Promote Sleep
Yurgel, G3 (Bethesda, Md.) 2018 - “...708.75 1.07 23.50 52.07 FBgn0039299 57194 CG11854 1085.00 402.92 682.08 1.20 32.67 35.62 FBgn0039649 51476 CG11899 899.06 245.00 654.06 0.75 33.38 28.42 FBgn0039330 53379 CG11909 1085.63 419.38 666.25 0.78 29.19 41.18 FBgn0035228 40936 CG12091 1040.31 345.63 694.69 0.86 27.75 38.68 FBgn0027842 33635 CG12891 1060.00 397.50 662.50...”
- Serine metabolism in the brain regulates starvation-induced sleep suppression in Drosophila melanogaster
Sonn, Proceedings of the National Academy of Sciences of the United States of America 2018 - “...1 E ). Heat-map analysis revealed that genes involved in serine synthesis ( CG6287 , CG11899 , and aay ) were all up-regulated after 6 and 24 h of starvation ( Fig. 1 F ). aay -Dependent Serine Synthesis Is Required for Starvation-Induced Sleep Suppression. To...”
- New negative feedback regulators of Egfr signaling in Drosophila
Butchar, Genetics 2012 - “...in EgfrDN Gene CG13053 CG4382 CG31075 Fbp2 CG4778 CG11899 CG9027 BM-40-SPARC CG6448 Ance GstE1 Mgstl CG10359 CG10200 AnnX CG7860 CG17746 Idgf4 SP1029 Cyp4e2...”
- “...SPARC -1.83 calcium ion binding* CG9027 -1.86 CG11899 -1.89 oxidoreductase activity;antioxidant activity transaminase activity obst-B -1.95 Fbp2 -2.1 CG31075...”
- Drosophila selenophosphate synthetase 1 regulates vitamin B6 metabolism: prediction and confirmation
Lee, BMC genomics 2011 - “...Gene-set Represented biological process Max. corrected p-value Selected genes Early/down Vitamin B6 biosynthesis 2.48 e-02 CG11899, CG31472 Late/up Defense response 6.22 e-08 AttB, AttD, CecB, DptB, Dro, Drs, Mtk, egr, pirk, PGRP-LF, PGRP-SD, W, Cyp6a8, Cyp12a4, Toll-7 Carboxylic acid metabolism (Amino acid metabolism) 8.17 e-05 arg,...”
- “...in Figure 3B , the level of expression of the early/down genes ( CG31472 and CG11899 ) was not changed by 4-DPN treatment. Because 4-DPN inhibits only the function of proteins that participate in PLP synthesis and does not affect the expression of genes encoding those...”
- Comparing peripheral glial cell differentiation in Drosophila and vertebrates
Rodrigues, Cellular and molecular life sciences : CMLS 2011 - “...Pglym78; Pglym87 Q9Z1B3 Plcb1 CG4574 Plc21C Q99K85 Psat1 CG11899 CG11899 P67778 Phb CG10691 l(2)37Cc O35129 Phb2 CG15081 l(2)03709* P27773 Pdia3 CG8983 ERp60*...”
- More
- Neu-Laxova syndrome is a heterogeneous metabolic disorder caused by defects in enzymes of the L-serine biosynthesis pathway
Acuna-Hidalgo, American journal of human genetics 2014 - “...rerio (RefSeq NP_956113.1), Drosophila melanogaster (UniProt ID Q9VAN0), Caenorhabditis elegans (UniProt ID P91856), and Escherichia coli (UniProt ID Q8XEA7)...”
Q99K85 Phosphoserine aminotransferase from Mus musculus
NP_803155 phosphoserine aminotransferase isoform 1 from Mus musculus
50% identity, 97% coverage
- Periostin Protects Against Alcohol-related Liver Disease by Activating Autophagy by Interacting With Protein Disulfide Isomerase.
Zhang, Cellular and molecular gastroenterology and hepatology 2023 - “...4 Q93092 Taldo1 Transaldolase 4 1 1 Q99JY9 Actr3 Actin-related protein 3 11 3 3 Q99K85 Psat1 Phosphoserine aminotransferase 6 2 2 Q99M74 Krt82 Keratin type II cuticular Hb2 4 2 1 Q99N42 Tymp Thymidine phosphorylase 2 1 1 Q9CPY7 Lap3 Cytosol aminopeptidase 2 1 1...”
- Protein Expression Analysis of an In Vitro Murine Model of Prostate Cancer Progression: Towards Identification of High-Potential Therapeutic Targets
Bahmad, Journal of personalized medicine 2020 - “...0.0209 O55131 Septin-7 Sept7 50,550 1.4336 0.0409 Q8BGQ7 AlaninetRNA ligase, cytoplasmic Aars 106,909 1.4824 0.0113 Q99K85 Phosphoserine aminotransferase Psat1 40,473 1.4994 0.0014 Q6IRU2 Tropomyosin alpha-4 chain Tpm4 28,468 1.5363 0.0019 P62814 V-type proton ATPase subunit B, brain isoform Atp6v1b2 56,551 1.5772 0.0284 P99029 Peroxiredoxin-5, mitochondrial Prdx5...”
- Proteome-wide Changes in the mdx-4cv Spleen due to Pathophysiological Cross Talk with Dystrophin-Deficient Skeletal Muscle.
Dowling, iScience 2020 - “...beta Ero1b 2 4.7424 0.0168 1.8 Q62087 Serum paraoxonase/lactonase 3 Pon3 4 13.6453 0.0167 1.7 Q99K85 Phosphoserine aminotransferase Psat1 4 11.5566 0.0174 1.7 Q9DBF1 Alpha-aminoadipic semialdehyde dehydrogenase Aldh7a1 4 10.4946 0.0308 1.7 O08807 Peroxiredoxin-4 Prdx4 3 8.6493 0.0172 1.7 P61620 Protein transport protein Sec61 subunit alpha...”
- Quantitative Proteomic Analysis of Cellular Responses to a Designed Amino Acid Feed in a Monoclonal Antibody Producing Chinese Hamster Ovary Cell Line
Torkashvand, Iranian biomedical journal 2018 - “...factor G3HY08 1.8 P34884 15 Glutathione S-transferase G3I5H1 1.8 P24472 16 Phosphoserine aminotransferase G3IKH9 1.7 Q99K85 17 Macrophage metalloelastase G3GUV3 1.7 Q63341 18 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 2 G3I6D1 1.7 P24815 19 Calponin G3I3W0 1.7 Q9DAW9 20 von Willebrand factor A domain-containing protein 5A G3IMX9...”
- Photoreceptor-induced RPE phagolysosomal maturation defects in Stargardt-like Maculopathy (STGD3)
Dejos, Scientific reports 2018 - “...B chain 7.91 Q8BKC5 Ipo5 Importin-5 6.12 Q78ZA7 Nap1l4 Nucleosome assembly protein 1-like 4 4.62 Q99K85 Psat1 Phosphoserine aminotransferase 4.51 Q921M7 Fam49b Protein FAM49B 3.82 P16330 Cnp 2,3-cyclic-nucleotide 3-phosphodiesterase 3.77 P14602 Hspb1 Heat shock protein beta-1 3.60 P53994 Rab2a Ras-related protein Rab-2A 0.33 P97457 Mylpf Myosin...”
- Proteomics Reveals Scope of Mycolactone-mediated Sec61 Blockade and Distinctive Stress Signature.
Morel, Molecular & cellular proteomics : MCP 2018 - A threshold of endogenous stress is required to engage cellular response to protect against mutagenesis.
Saintigny, Scientific reports 2016 - “...isomerase A P14851 6 1,45 U2 small nuclear ribonucleoprotein A P57784 7 1,83 Phosphoserine aminotransferase Q99K85 10 1,47 Destrin Q7M0E3 12 1,66 Ubiquitin-conjugating enzyme E2 variant 1 Q9CZY3 12 1,66 Dihydropteridine reductase P11348 13 1,53 Voltage-dependent anion-selective channel protein 2 Q60930 14 1,42 ELAV-like protein 1...”
- Proteomic profiling of the retinas in a neonatal rat model of oxygen-induced retinopathy with a reproducible ion-current-based MS1 approach.
Tu, Journal of proteome research 2015 - “...Cend1 cell cycle exit and neuronal differentiation protein 1 4 0.74 0.06 <0.01 cytoskeleton organization Q99K85 Psat1 phosphoserine aminotransferase 2 0.74 0.05 <0.01 organic acid metabolic process P37805 Tagln3 transgelin-3 6 0.74 0.05 <0.01 muscle organ development Q4V8B0 Oxr1 oxidation resistance protein 1 3 0.74 0.13...”
- More
- Psat1-generated α-ketoglutarate and glutamine promote muscle stem cell activation and regeneration.
Ciuffoli, Genes & development 2024 - GeneRIF: Psat1-generated alpha-ketoglutarate and glutamine promote muscle stem cell activation and regeneration.
- Psat1-Dependent Fluctuations in α-Ketoglutarate Affect the Timing of ESC Differentiation.
Hwang, Cell metabolism 2016 (PubMed)- GeneRIF: Psat1 is regulated in maintaining intracellular alpha-ketoglutarate levels and determining the fate of mouse Embryonic stem cells.
- Hepatic Phosphoserine Aminotransferase 1 Regulates Insulin Sensitivity in Mice via Tribbles Homolog 3.
Yu, Diabetes 2015 (PubMed)- GeneRIF: This study showed that hepatic PSAT1 expression and liver serine levels are reduced in 2 mouse strains, and that PSAT1 inhibited the expression of hepatic TRB3 in vitro and in vivo.
B4DHQ3 Phosphoserine aminotransferase from Homo sapiens
50% identity, 86% coverage
- Unique proteome signature of post-chemotherapy ovarian cancer ascites-derived tumor cells.
Ahmed, Scientific reports 2016 - “...mRNA splicing, via spliceosome; metal ion binding; ribonucleoprotein complex; termination of RNA polymerase II transcription B4DHQ3 PSAT Phosphoserine aminotransferase 1 10 5.6 L-serine biosynthetic process; O-phospho-L-serine:2-oxoglutarate aminotransferase activity; pyridoxal phosphate binding Q8NFF5 FLAD1 FAD synthase 3 19 5.3 ATP binding; FAD biosynthetic process; FMN adenylyltransferase activity;...”
lmo2825 highly similar to phosphoserine aminotransferase from Listeria monocytogenes EGD-e
53% identity, 98% coverage
Q68FU2 Phosphoserine aminotransferase from Rattus norvegicus
50% identity, 97% coverage
XP_063143070 phosphoserine aminotransferase isoform X1 from Rattus norvegicus
50% identity, 97% coverage
Q8LMR0 Phosphoserine aminotransferase from Oryza sativa subsp. japonica
53% identity, 83% coverage
- iTRAQ based proteomic analysis of rice lines having single or stacked blast resistance genes: Pi54/Pi54rh during incompatible interaction with Magnaporthe oryzae
Kumari, Physiology and molecular biology of plants : an international journal of functional plant biology 2023 - “...germin-like protein (Q65XA1, Q6ZCR3), and aminotransferase (Q10R45, Q8LMR0), three loci of PR-10 family protein pathogenesis-related Bet v I family protein...”
- ITRAQ-based quantitative proteomic analysis of japonica rice seedling during cold stress
Qing, Breeding science 2022 - “...LOC_Os07g05820 Peroxisomal (S)-2-hydroxy-acid oxidase GLO5 38 65.85 1.84 A0A0P0WP33 LOC_Os05g41640.1 Phosphoglycerate kinase 41 68.18 2.42 Q8LMR0 LOC_Os03g06200 Phosphoserine aminotransferase 10 26.76 1.72 Q8GT95 LOC_Os07g38130 Polygalacturonase inhibitor 1 8 32.83 0.54 Q6AT26 LOC_Os05g08370 Probable cellulose synthase A catalytic subunit 1 [UDP-forming] 5 5.30 1.39 Q53LQ0 LOC_Os11g09280 Protein...”
- “...chloroplastic 14 25.60 2.42 A0A0P0WP33 Phosphoglycerate kinase 41 68.18 2.27 Q6Z8F4 Phosphoribulokinase 27 57.32 1.53 Q8LMR0 Phosphoserine aminotransferase 10 26.76 1.77 P0C355 Photosystem I P700 chlorophyll a apoprotein A1 19 16.80 1.51 P0C364 Photosystem II CP47 reaction center protein 24 31.89 2.54 P0C434 Photosystem II protein...”
- Lipid and Protein Oxidation of Brown Rice and Selenium-Rich Brown Rice during Storage.
Zhang, Foods (Basel, Switzerland) 2022 - “...0.6081 0.5058 - Q8S5T1 1410 Glutathione reductase - - 1.5560 - Cysteine and methionine metabolism Q8LMR0 317 Phosphoserine aminotransferase - - 1.9588 - Q0JJ47 50 Aspartate aminotransferase 2.0512 2.5351 - - Q2QLY4 72 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferase 2 - - 2.1677 1.5276 Q9XEA8 506 Cysteine synthase - -...”
- Proteomic response of hybrid wild rice to cold stress at the seedling stage
Wang, PloS one 2018 - “...S27 0.38 Others Q10R17 Adenylosuccinate synthetase 1, chloroplastic 2.42 A0A0P0V9F2 Cysteine proteinase inhibitor (Fragment) 2.28 Q8LMR0 Phosphoserine aminotransferase 1.69 Q5N8G1 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase, chloroplastic 1.64 Q6ERX1 Probable cinnamyl alcohol dehydrogenase 8A 1.56 Q69U53 MAP3K-like protein 1.54 Q0DYB1 Soluble inorganic pyrophosphatase 1.54 Q2QLY4 5-methyltetrahydropteroyltriglutamatehomocysteine methyltransferase 2 0.67...”
- Proteomic changes associated with expression of a gene (ipt) controlling cytokinin synthesis for improving heat tolerance in a perennial grass species
Xu, Journal of experimental botany 2010 - “...Plastid, mitochondrion 61354/8.82 597 Q7Y1F0 241 1.5 Phosphoserine aminotransferase [Oryza sativa] Plastid, mitochondrion 44931/8.53 370 Q8LMR0 262 0.2 Nucleotide-sugar dehydratase [ Arabidopsis thaliana ] Plastid 38621/8.58 504 F84688 02. Energy 53 0.6 Aconitate hydratase (aconitase) [ Cucurbita maxima ] Cytoplasm 98005/5.74 251 P49608 57 0.6 0.6...”
- Root proteomic responses to heat stress in two Agrostis grass species contrasting in heat tolerance
Xu, Journal of experimental botany 2008 - “...heat stress Category 01 Metabolism 48 Phosphoserine aminotransferase (EC 2.6.1.52) [ Oryza sativa ] 8.53/44931 Q8LMR0 243 7 N**, P*** 49 Phosphoserine aminotransferase (EC 2.6.1.52) [ Oryza sativa ] 8.53/44931 Q8LMR0 380 7 N*** 50 Phosphoserine aminotransferase (EC 2.6.1.52) [ Oryza sativa ] 8.53/44931 Q8LMR0 420...”
Q9KDM4 Phosphoserine aminotransferase from Halalkalibacterium halodurans (strain ATCC BAA-125 / DSM 18197 / FERM 7344 / JCM 9153 / C-125)
52% identity, 99% coverage
NGFG_02407 phosphoserine transaminase from Neisseria gonorrhoeae MS11
52% identity, 97% coverage
NMB1640 phosphoserine aminotransferase from Neisseria meningitidis MC58
51% identity, 97% coverage
B4FRI1 Phosphoserine aminotransferase from Zea mays
52% identity, 83% coverage
- Insights of cellular and molecular changes in sugarcane response to oxidative signaling
Silva, BMC plant biology 2025 - “...B8A046 Phenylalanine ammonia-lyase, EC 4.3.1.24 Zea mays Root 2.00 0.01681 2.00 0.01681 2.00 0.01681 194701280 B4FRI1 Phosphoserine aminotransferase, EC 2.6.1.52 Zea mays Root 1.67 0.02355 1.67 0.02355 1.67 0.02355 242051489 C5XJN6 PNP_UDP_1 domain-containing protein Sorghum bicolor Root 2.33 0.01784 2.33 0.01784 2.33 0.01784 22759727 Q8LNX8 Putative...”
- “...mays Root Decreased 2.00 0.01681 2.00 0.01681 2.00 0.01681 Phenylalanine metabolism Biosynthesis of secondary metabolites B4FRI1 Phosphoserine aminotransferase, EC 2.6.1.52 Zea mays Root Decreased 1.67 0.02355 1.67 0.02355 1.67 0.02355 Vitamin B6 metabolism Cysteine and methionine metabolism Biosynthesis of amino acids C5Z4W3 caffeoyl-CoA O-methyltransferase 1 Sorghum...”
APJL_0700 phosphoserine aminotransferase from Actinobacillus pleuropneumoniae serovar 3 str. JL03
48% identity, 99% coverage
SERC_ALKAL / Q9RME2 Phosphoserine aminotransferase; Phosphohydroxythreonine aminotransferase; PSAT; EC 2.6.1.52 from Alkalihalobacillus alcalophilus (Bacillus alcalophilus) (see 3 papers)
Q9RME2 phosphoserine transaminase (EC 2.6.1.52) from Alkalihalobacillus alcalophilus (see paper)
49% identity, 99% coverage
- function: Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine.
catalytic activity: O-phospho-L-serine + 2-oxoglutarate = 3-phosphooxypyruvate + L-glutamate (RHEA:14329)
catalytic activity: 4-(phosphooxy)-L-threonine + 2-oxoglutarate = (R)-3-hydroxy-2- oxo-4-phosphooxybutanoate + L-glutamate (RHEA:16573)
cofactor: pyridoxal 5'-phosphate (Binds 1 pyridoxal phosphate per subunit.)
subunit: Homodimer.
4azjA / Q9RME2 Structural basis of l-phosphoserine binding to bacillus alcalophilus phosphoserine aminotransferase (see paper)
49% identity, 99% coverage
- Ligands: phosphoserine; pyridoxal-5'-phosphate (4azjA)
APL_0702 phosphoserine aminotransferase from Actinobacillus pleuropneumoniae L20
48% identity, 99% coverage
- Effects of growth conditions on biofilm formation by Actinobacillus pleuropneumoniae
Labrie, Veterinary research 2010 - “...isozyme II small subunit (AHAS-II) 2.934 APL_2027 hisF Imidazole glycerol phosphate synthase subunit hisF 2.833 APL_0702 serC Phosphoserine aminotransferase 2.788 APL_0432 leuB 3-isopropylmalate dehydrogenase 2.643 APL_0899 dapA Dihydrodipicolinate synthase 2.401 APL_0211 glyA Glycine/serine hydroxymethyltransferase 2.398 APL_0133 cysB HTH-type transcriptional regulator CysB 2.340 APL_1853 ilvC Ketol-acid reductoisomerase...”
Q2F5M8 phosphoserine transaminase (EC 2.6.1.52) from Bombyx mori (see paper)
NP_001040269 phosphoserine aminotransferase 1 from Bombyx mori
50% identity, 98% coverage
XHV734_3367 3-phosphoserine/phosphohydroxythreonine transaminase from Xanthomonas hortorum pv. vitians
51% identity, 99% coverage
Q3U6K9 Phosphoserine aminotransferase from Mus musculus
50% identity, 93% coverage
3qm2B / P55900 2.25 angstrom crystal structure of phosphoserine aminotransferase (serc) from salmonella enterica subsp. Enterica serovar typhimurium
52% identity, 99% coverage
- Ligand: calcium ion (3qm2B)
PD1358 phosphoserine aminotransferase from Xylella fastidiosa Temecula1
50% identity, 100% coverage
- The Exometabolome of Xylella fastidiosa in Contact with Paraburkholderia phytofirmans Supernatant Reveals Changes in Nicotinamide, Amino Acids, Biotin, and Plant Hormones
Feitosa-Junior, Metabolites 2024 - “...RHEA:18633 6.33 PD2062 2.00 200.00 RHEA:11613 200.00 RHEA:11613 6.33 2.00 200.00 RHEA:15504 200.00 RHEA:15504 6.33 PD1358 2.00 200.00 RHEA:16574 200.00 RHEA:16574 6.33 2.00 200.00 RHEA:14329 200.00 RHEA:14329 6.33 PD1266 2.00 200.00 RHEA:23746 200.00 RHEA:23746 6.33 PD0089 2.00 200.00 RHEA:12228 200.00 RHEA:12228 6.33 PD0839 2.00 200.00 RHEA:24385...”
- The Secreted Protease PrtA Controls Cell Growth, Biofilm Formation and Pathogenicity in Xylella fastidiosa
Gouran, Scientific reports 2016 - “...proA (PD0297), pheA (PD0426), aroK (PD0582), asd (PD0608), aspH (PD0777), trpDE (PD0876 and PD0877), serC (PD1358), leuB (PD1397), cofactor recycling cysG (PD1840), folP (PD0068), ptr1 (PD0677), nadA (PD0869), grx (PD1409), ribF (PD1438), folB (PD1642), terpenoid dxr (PD0328), phosphate uptake oprO (PD0270), ammonium uptake amtB (PD1024), sugar...”
SSA_1715 Phosphoserine aminotransferase, putative from Streptococcus sanguinis SK36
52% identity, 98% coverage
- Systematic study of genes influencing cellular chain length in Streptococcus sanguinis
Evans, Microbiology (Reading, England) 2014 - “...chains in their mutants with upregulated gene expressions in Ssx_1972. These genes were SSA_0759, SSA_0760, SSA_1715, SSA_1897, SSA_2117, SSA_2141, SSA_2159 and SSA_2337. All positively and negatively related genes should contribute to the cellular chain length of Ssx_1972. However, there were also downregulated genes showing shorter chain...”
- “...0.0512 Y SSA_0759 argB Acetylglutamate kinase 3.1950 0.6376 Y SSA_0760 Acetylornithine aminotransferase 9.4869 4.9372 Y SSA_1715 serC Phosphoserine aminotransferase 2.0630 1.0319 Y SSA_1897 Hypothetical protein SSA_1897 2.2604 0.6261 Y SSA_2117 rmuC DNA recombination protein RmuC 2.5179 0.7197 Y SSA_2141 argH Argininosuccinate lyase 4.6751 3.6790 Y SSA_2159...”
F1SIJ9 Phosphoserine aminotransferase from Sus scrofa
50% identity, 93% coverage
Q88ZU5 Phosphoserine aminotransferase from Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)
49% identity, 98% coverage
MHA_1780 3-phosphoserine/phosphohydroxythreonine transaminase from Mannheimia haemolytica PHL213
47% identity, 98% coverage
- A three-way comparative genomic analysis of Mannheimia haemolytica isolates
Lawrence, BMC genomics 2010 - “...such as the UDP N acetylglucosamine 2 epimerase (MHA_0505), capsule biosynthesis protein (MHA_0507) and sialyltransferase (MHA_1780), indicating their possible role in conferring serotype specificity. Similarly, 57% of the B genome specific genes are hypothetical proteins and 29% are phage proteins. Among the B specific genes, enzymes...”
LOC100163589 probable phosphoserine aminotransferase from Acyrthosiphon pisum
48% identity, 97% coverage
- The boom and bust of the aphid's essential amino acid metabolism across nymphal development
Pers, G3 (Bethesda, Md.) 2021 - “...PAH 1.14.16.1 Down LOC100159560 Cystathionase-likeF 4.4.1.1 Down Down LOC100160139 Glutamine synthetase 2; GS2 6.3.1.2 Down LOC100163589 Phosphoserine transaminase 2.6.1.52 Down LOC100161178 L-Threonine aldolase 2 4.1.2.48 Down LOC100160265 Asparagine synthase 6.3.5.4 Down Down LOC100164179 Asparaginase 3.5.1.1; 3.1.1.5 Down LOC100160095 Asparaginase 3.5.1.121 Down LOC100167144 Asparaginase 3.5.1.121 Down a...”
- Aphid genome expression reveals host-symbiont cooperation in the production of amino acids
Hansen, Proceedings of the National Academy of Sciences of the United States of America 2011 - “...LOC100165735 LOC100167268 LOC100160394 LOC100168149 LOC100163589 LOC100158884 LOC100158884 LOC100144899 LOC100161812 LOC100163139 LOC100165255 LOC100160265...”
- “...Lys Lys Thr 4.1.2.5 LOC100161178 Gly Asn 2.6.1.52 LOC100163589 His Thr Ala Cys Ser Cys 3.1.3.3 LOC100158884 NH homocysteine Sulfate reduction MetE 1.1.1.95...”
A0A3Q7F688 Phosphoserine aminotransferase from Solanum lycopersicum
52% identity, 91% coverage
SMU_RS07515 3-phosphoserine/phosphohydroxythreonine transaminase from Streptococcus mutans UA159
51% identity, 98% coverage
XF2326 phosphoserine aminotransferase from Xylella fastidiosa 9a5c
Q9PB19 Phosphoserine aminotransferase from Xylella fastidiosa (strain 9a5c)
49% identity, 100% coverage
- In vitro Determination of Extracellular Proteins from Xylella fastidiosa
Mendes, Frontiers in microbiology 2016 - “...0.538 Phage-related protein, xfp4 30.4 XF1649 XF1379 P76513 No No 0.065 Phosphoserine aminotransferase (PSAT) 39.6 XF2326 XF2012 Q9PB19 No No 0.163 PilA2 Tfp pilus assembly protein, 15.4 XF2539 XF2216 P17837 No No 0.937 Porin O (POP) 43.7 XF0975 XF0803 P33976 No No 0.717 POP O (POP)...”
- In vitro Determination of Extracellular Proteins from Xylella fastidiosa
Mendes, Frontiers in microbiology 2016 - “...protein, xfp4 30.4 XF1649 XF1379 P76513 No No 0.065 Phosphoserine aminotransferase (PSAT) 39.6 XF2326 XF2012 Q9PB19 No No 0.163 PilA2 Tfp pilus assembly protein, 15.4 XF2539 XF2216 P17837 No No 0.937 Porin O (POP) 43.7 XF0975 XF0803 P33976 No No 0.717 POP O (POP) 45 XF0321...”
HI1167 phosphoserine aminotransferase (serC) from Haemophilus influenzae Rd KW20
47% identity, 99% coverage
BSU10020 phosphoserine aminotransferase from Bacillus subtilis subsp. subtilis str. 168
48% identity, 99% coverage
- A Survey of Pyridoxal 5'-Phosphate-Dependent Proteins in the Gram-Positive Model Bacterium Bacillus subtilis
Richts, Frontiers in molecular biosciences 2019 - “...Cystathionine -lyase Methionine biosynthesis Unknown PLP AAT class II family Auger et al., 2005 SerC BSU10020 No 2.6.1.52 1W23 ( Bacillus alcalophilus , 59%) 3-Phosphoserine aminotransferase Serine biosynthesis Unknown PLP AAT class V family Sakai et al., 2002a ThrC BSU32250 No 4.2.3.1 1UIN ( Thermus thermophilus...”
- A Flexible Binding Site Architecture Provides New Insights into CcpA Global Regulation in Gram-Positive Bacteria
Yang, mBio 2017 - “...Attribution 4.0 International license . We chose five potential cre var sites from both B.subtilis (BSU10020, BSU14580, BSU22720, BSU27620, and BSU35080) and C.perfringens (CPF0042, CPF0484, CPF0526, CPF0580, and CPF1663) for EMSA verification. B.subtilis CcpA and C.perfringens CcpA were purified and used for functional analysis of the...”
- The Blueprint of a Minimal Cell: MiniBacillus
Reuß, Microbiology and molecular biology reviews : MMBR 2016 - “...E. coli Asparagine synthase (glutamine hydrolyzing) BSU31400 BSU23070 BSU10020 BSU35850 No No No No 2.6.1.1.1.1.95 2.6.1.52 1DJU 1YGY 1W23 1NRW P. horikoshii...”
XP_004337318 phosphoserine transaminase from Acanthamoeba castellanii str. Neff
45% identity, 91% coverage
LLNZ_02900 3-phosphoserine/phosphohydroxythreonine transaminase from Lactococcus cremoris subsp. cremoris NZ9000
llmg_0565 phosphoserine aminotransferase from Lactococcus lactis subsp. cremoris MG1363
47% identity, 97% coverage
BFP66_RS05970, ZY05719_03235 3-phosphoserine/phosphohydroxythreonine transaminase from Streptococcus suis
SSU0621 phosphoserine aminotransferase from Streptococcus suis P1/7
49% identity, 98% coverage
- Establishment of Streptococcus suis Biofilm Infection Model In Vivo and Comparative Analysis of Gene Expression Profiles between In Vivo and In Vitro Biofilms
Yi, Microbiology spectrum 2023 - “...murB AKG40137.1 UDP- N -acetylenolpyruvoylglucosamine reductase Transmembrane transport ZY05719_03890 AKG40139.1 Spermidine/putrescine ABC transporter permease I ZY05719_03235 AKG40022.1 MFS transporter ZY05719_09375 AKG41185.1 Bacterocin transport accessory protein, Bta Transcriptional regulation ZY05719_08635 AKG41044.1 LacI family transcriptional regulator ZY05719_01875 AKG39775.1 MerR family transcriptional regulator Signal transduction ZY05719_07905 AKG40901.1 Two-component regulator,...”
- “...in vitro biofilm transcriptomic data, with the exceptions being ZY05719_02660, ZY05719_02335, ZY05719_06545, ZY05719_03880, ZY05719_09920, and ZY05719_03235, which to a certain extent verifies the reliability of SCOTS technology in the screening of gene expression differences under specific conditions (Table S2). In addition, about 8.7% of genes could...”
- Streptococcus suis synthesizes deoxyadenosine and adenosine by 5'-nucleotidase to dampen host immune responses
Dai, Virulence 2018 - “...suis strain GZ0565 (unpublished data), there is no transcript at the genomic intergenic region between BFP66_RS05970 and BFP66_RS05975 where the gene nt could be inserted into. The complemented strain for nt was constructed according to our previous report [ 25 ]. A fragment of the genome...”
- Identification of conditionally essential genes for Streptococcus suis infection in pigs
Arenas, Virulence 2020 - “...purB Adenylosuccinate lyase 4.7 9.1 4.0 SSU0378 gmk Guanylate kinase 3.5 Biosynthesis of amino acids SSU0621 serC Phosphoserine aminotransferase 10.2 8.9 3.2 SSU1325 Haloacid dehalogenase 4.11 7.8 5.3 SSU0319 Aminotransferase 3.1 5.6 SSU1720 cysE Serine acetyltransferase 4.3 3.0 4.7 SSU0748 thrB Homoserine kinase 8.7 7.6 SSU0671...”
Ssal_00537 3-phosphoserine/phosphohydroxythreonine transaminase from Streptococcus salivarius 57.I
49% identity, 98% coverage
V9NC98 phosphoserine transaminase (EC 2.6.1.52) from Acanthamoeba castellanii (see paper)
44% identity, 91% coverage
P91856 Probable phosphoserine aminotransferase from Caenorhabditis elegans
43% identity, 96% coverage
G3IKH9 phosphoserine transaminase from Cricetulus griseus
51% identity, 83% coverage
XP_001327551 phosphoserine aminotransferase from Trichomonas vaginalis G3
43% identity, 96% coverage
PSAT1 / A2FXW5 phosphoserine transaminase (EC 2.6.1.52) from Trichomonas vaginalis (strain ATCC PRA-98 / G3) (see paper)
43% identity, 96% coverage
Cj0326 phosphoserine aminotransferase from Campylobacter jejuni subsp. jejuni NCTC 11168
44% identity, 99% coverage
- Cysteine Biosynthesis in Campylobacter jejuni: Substrate Specificity of CysM and the Dualism of Sulfide
Hitchcock, Biomolecules 2022 - “...either O-acetyl-L-serine (OAS) or O-phospho-L-serine (OPS) by serine acetyltransferase (CysE, Cj0763) or phosphoserine aminotransferase (SerC, Cj0326), respectively [ 9 , 10 ]. The resultant metabolites act as sulfur acceptors in the generation of cysteine by either OAS sulfhydrylase (OASS) or OPS sulfhydrylase (OPSS), broadly referred to...”
- In vivo and in silico determination of essential genes of Campylobacter jejuni
Metris, BMC genomics 2011 - “...cj0197c, cj0205, cj0227, cj0237, cj0240c, cj0273, cj0274, cj0286c, cj0288c, cj0296c, cj0297c, cj0298c, cj0306c, cj0307, cj0321, cj0326, cj0332c, cj0360, cj0384c, cj0405, cj0432c, cj0433c, cj0434, cj0435, cj0437, cj0443, cj0453, cj0490, cj0541, cj0542, cj0559, cj0576, cj0580c, cj0585, cj0589, cj0638c, cj0647, cj0699c, cj0716, cj0764c, cj0766c, cj0767c, cj0795c, cj0798c, cj0806, cj0813,...”
PGN_0612 phosphoserine aminotransferase from Porphyromonas gingivalis ATCC 33277
PG1278 phosphoserine aminotransferase from Porphyromonas gingivalis W83
44% identity, 99% coverage
- PGN_0297 is an essential component of the type IX secretion system (T9SS) in Porphyromonas gingivalis: Tn-seq analysis for exhaustive identification of T9SS-related genes
Naito, Microbiology and immunology 2019 - “...PGN_0538 1 Conserved hypothetical protein 7 PGN_0589 1 Conserved hypothetical protein 8 5intergenic region of PGN_0612 2 Phosphoserine aminotransferase 9 PGN_0617 1 Conserved hypothetical protein 10 PGN_0700 1 Putative oxidoreductase Gfo/Idh/MocA family 11 PGN_0786 1 Conserved hypothetical protein 12 PGN_0973 1 Conserved hypothetical protein 13 PGN_1195...”
- Metabolic cooperativity between Porphyromonas gingivalis and Treponema denticola
Kin, Journal of oral microbiology 2020 - “...In the pathway for serine, glycine and threonine metabolism, the gene encoding phosphoserine aminotransferase (serC, PG1278 ) was up-regulated 1.51-fold, whilst the gene encoding the iron-sulfur-dependent L-serine dehydratase ( sda, PG0084 ) was down-regulated 1.79-fold ( Figure 2 ). The overall effect on this metabolic pathway...”
- Protein Analysis of Sapienic Acid-Treated Porphyromonas gingivalis Suggests Differential Regulation of Multiple Metabolic Pathways
Fischer, Journal of bacteriology 2016 - “...dehydrogenase (HprA; PG1990) and phosphoserine aminotransferase (SerC; PG1278). Serine is particularly important because it also serves as an intermediate for...”
- “...proteins KEGG pathway Carbon metabolism 1200 PG2124, PG1278, PG1417, PG1190, PG0548, PG1755, PG1812, PG1809 PG1417, PG1278, PG1190, PG2124, PG1755, PG0429,...”
- Effects of various growth conditions in a chemostat on expression of virulence factors in Porphyromonas gingivalis
Masuda, Applied and environmental microbiology 2006 - “...PG1940 PG1208 PG0520 PG0762 PG0692 PG2142 PG1232 PG0694 PG1278 PG1279 PG1764 PG0506 PG2024 PG0449 PG0506 PG2024 PG1824 PG1804 PG1385 PG0027 PG0343 PG0776 PG1755...”
BTH_I1966 phosphoserine aminotransferase from Burkholderia thailandensis E264
44% identity, 98% coverage
RAYM_04219 3-phosphoserine/phosphohydroxythreonine transaminase from Riemerella anatipestifer RA-YM
45% identity, 97% coverage
- The Role of the Regulator Fur in Gene Regulation and Virulence of Riemerella anatipestifer Assessed Using an Unmarked Gene Deletion System
Guo, Frontiers in cellular and infection microbiology 2017 - “...-Fe/ fur +Fe fur -Fe/WT+Fe fur +Fe/WT+Fe BIOSYNTHESIS OF AMINO ACIDS, COFACTORS, AND PROSTHETIC GROUPS RAYM_04219 Phosphoserine aminotransferase 1.35 1.25 RAYM_04224 D-3-phosphoglycerate dehydrogenase 1.35 1.19 RAYM_04506 Thiamine biosynthesis protein ApbE 1.84 3.37 RAYM_06215 Aminodeoxychorismate lyase 1.08 1.12 RAYM_06377 Para-aminobenzoate synthase component I 1.53 1.01 CELL ENVELOPE...”
- “...coli in previous studies (Outten et al., 2004 ). Moreover, the genes Phosphoserine aminotransferase ( RAYM_04219 ), D-3-phosphoglycerate-dehydrogenase ( RAYM_04224 ) controlling the shikimate pathway were upregulated. D-3-phosphoglycerate-dehydrogenase (pabB) converts chorismate to 4-amino-4-deoxychorismate (ADC) and phosphoserine aminotransferase (pabC) converts ADC to p-aminobenzoate (PABA) and pyruvate (Green...”
ATE51_03558 phosphoserine transaminase from Campylobacter coli
45% identity, 99% coverage
BPSL2219 putative phosphoserine aminotransferase from Burkholderia pseudomallei K96243
42% identity, 99% coverage
- Pathogenicity and virulence of Burkholderia pseudomallei
Bzdyl, Virulence 2022 - “...involved in the TCA cycle ( fumC, sucD and phbB ), serine catabolism/synthesis ( glyA, BPSL2219 ), and energy metabolism (ATP-synthase, NADH-dehydrogenase) were highly down regulated [ 165 ]. The switch to alternative energy sources may be an adaptation for acute infection, which the Syrian hamster...”
- Genome-wide expression analysis of Burkholderia pseudomallei infection in a hamster model of acute melioidosis
Tuanyok, Infection and immunity 2006 - “...protein BPSL2082 Conserved hypothetical protein BPSL2219 Putative phosphoserine aminotransferase BPSL2557 cspA, cold shock-like protein BPSL2881 Putative...”
- “...BPSS0547 (glyA, serine hydroxymethyltransferase) and BPSL2219 (putative phosphoserine aminotransferase). These differentially expressed genes were mostly found...”
EHI_026360 phosphoserine aminotransferase, putative from Entamoeba histolytica HM-1:IMSS
40% identity, 98% coverage
- Genetic, metabolomic and transcriptomic analyses of the de novo L-cysteine biosynthetic pathway in the enteric protozoan parasite Entamoeba histolytica
Jeelani, Scientific reports 2017 - “...respectively, whereas the expression of the SAT3 gene remained unchanged. The genes encoding phosphoserine aminotransferase (EHI_026360), which catalyzes the formation of L-phosphoserine from 3-phosphohydroxypyruvate in the phosphorylated pathway of L-serine biosynthesis 34 , were down-regulated more than five fold (Table 2 ). Among the most highly...”
- Overexpression of Differentially Expressed Genes Identified in Non-pathogenic and Pathogenic Entamoeba histolytica Clones Allow Identification of New Pathogenicity Factors Involved in Amoebic Liver Abscess Formation
Meyer, PLoS pathogens 2016 (no snippet) - Phenotypic and transcriptional profiling in Entamoeba histolytica reveal costs to fitness and adaptive responses associated with metronidazole resistance
Penuliar, Frontiers in microbiology 2015 - “...cell growth observed in MTZR may be partially explained by the repression of phosphoserine aminotransferase (EHI_026360) (Ali and Nozaki, 2006 ; Mishra et al., 2010 ), which catalyzes the conversion of 3-phosphohydroxypyruvate to L-phosphoserine, the second step of phosphorylated serine biosynthetic pathway (Ali and Nozaki, 2006...”
- Gene expression profiling in Entamoeba histolytica identifies key components in iron uptake and metabolism
Hernández-Cuevas, PloS one 2014 - “...NM 2.6 NM Methionine gamma lyase MGL1 EHI_144610 XM_647004 NM 2.1 NM Phosphoglycerate dehydrogenase PSAT EHI_026360 XM_650291 2.0 2.2 NM For definition of columns please refer to footnote of Table 2 . An iron-containing superoxide dismutase transcript was also identified. Levels of this transcript were not...”
- “...coding for D-3-phosphoglycerate dehydrogenase (PGDH, EHI_060860), methionine -lyase 1 (MGL1, EHI_144610), and phosphoserine aminotransferase (PSAT, EHI_026360) were downregulated in iron deficiency. The PGDH and PSAT transcripts were still downregulated after Hb supplementation. Stress responses, DNA repair and RNA synthesis A number of transcripts involved in stress...”
- Global analysis of gene expression in response to L-Cysteine deprivation in the anaerobic protozoan parasite Entamoeba histolytica
Husain, BMC genomics 2011 - “...CS2, EHI_160930; CS3, EHI_060340; MAT, 70.m00173; MGL1, EHI_144610; MGL2, EHI_142250; NifS; EHI_136380; PGDH, EHI_060860; PSAT, EHI_026360; SAHH, EHI_068250; SAT2, EHI_021570; SAT3, EHI_153430. We have recently shown by metabolomic analysis that the synthesis of OAS and SMC markedly increased upon L-cysteine deprivation in E. histolytica . OAS...”
TGME49_218780 phosphoserine aminotransferase, putative from Toxoplasma gondii ME49
39% identity, 74% coverage
5yb0B / Q60I38 Crystal structure of wild type phosphoserine aminotransferase (psat) from e. Histolytica (see paper)
40% identity, 98% coverage
- Ligand: pyridoxal-5'-phosphate (5yb0B)
BM43_2810 phosphoserine transaminase from Burkholderia gladioli
42% identity, 99% coverage
B7Q0D6 phosphoserine transaminase from Ixodes scapularis
51% identity, 73% coverage
FTT_0560c phosphoserine aminotransferase from Francisella tularensis subsp. tularensis SCHU S4
40% identity, 98% coverage
Q59P52 Phosphoserine aminotransferase from Candida albicans (strain SC5314 / ATCC MYA-2876)
42% identity, 90% coverage
SPAC1F12.07 phosphoserine aminotransferase (predicted) from Schizosaccharomyces pombe
39% identity, 93% coverage
- Identification of new players in cell division, DNA damage response, and morphogenesis through construction of Schizosaccharomyces pombe deletion strains
Chen, G3 (Bethesda, Md.) 2014 - “...deletion of two uncharacterized ORFs showed cell division defects that have not been previously reported. SPAC1F12.07 cells were slow-growing at low temperature and sensitive to TBZ, calcofluor white, and SDS, congruent with defects in cell morphogenesis. Microscopic imaging of SPAC1F12.07 cells showed that they were elongated...”
- “...cleave the daughter cells ( Figure 3, C and D ); a low percentage of SPAC1F12.07 cells formed no septa at all. SPAC1F12.07 is predicted to be a phosphoserine aminotransferase involved in L-serine biosynthesis ( Wood et al. 2012 ) and peaks in abundance during mitosis...”
SERC_YEAST / P33330 Phosphoserine aminotransferase; PSAT; Phosphohydroxythreonine aminotransferase; Serine requiring protein 1; EC 2.6.1.52 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see 6 papers)
SERC / AAA20886.1 3-phosphoserine aminotransferase from Saccharomyces cerevisiae (see paper)
NP_014827, YOR184W 3-phosphoserine aminotransferase, catalyzes the formation of phosphoserine from 3-phosphohydroxypyruvate, required for serine and glycine biosynthesis; regulated by the general control of amino acid biosynthesis mediated by Gcn4p from Saccharomyces cerevisiae
39% identity, 90% coverage
- function: Phosphoserine aminotransferase (PSAT) is a pyridoxal 5'- phosphate-dependent enzyme involved in the second step of the phosphorylated pathway of serine biosynthesis (PubMed:1326413). Catalyzes the reversible conversion of 3-phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4-phosphonooxybutanoate to phosphohydroxythreonine (PubMed:1326413). Plays an indirect role in purine biosynthesis (PubMed:10509016).
catalytic activity: O-phospho-L-serine + 2-oxoglutarate = 3-phosphooxypyruvate + L-glutamate (RHEA:14329)
catalytic activity: 4-(phosphooxy)-L-threonine + 2-oxoglutarate = (R)-3-hydroxy-2- oxo-4-phosphooxybutanoate + L-glutamate (RHEA:16573)
cofactor: pyridoxal 5'-phosphate (Binds 1 pyridoxal phosphate per subunit.)
subunit: Homodimer.
disruption phenotype: Impairs growth in absence of serine and leads to adenine bradytrophy (slow growth). - Regulation of xylose metabolism in recombinant Saccharomyces cerevisiae
Salusjärvi, Microbial cell factories 2008 - “...0.2 -2.5 -1.6 -2.4 -1.8 P07283 Sec53p_b YFL045C phosphomannomutase -1.1 0.2 -2.0 -1.6 -0.8 -1.8 P33330 Ser1p YOR184W phosphoserine transaminase -0.8 -0.3 -0.9 -1.0 -0.1 -0.8 P37291 Shm2p YLR058C glycine hydroxymethyltransferase 0.1 -0.1 -1.5 0.6 -1.6 0.7 Q03144 Sno1p YMR095C molecular function unknown 0.3 0.4 -0.8...”
- Genome-wide identification of resistance genes and transcriptome regulation in yeast to accommodate ammonium toxicity
Fu, BMC genomics 2022 - “...INP53 0.2873 0.00001 0.3000 0.00003 0.2175 0.00009 YOR171C LCB4 0.2718 0.00008 0.3479 0.00002 0.3126 0.00005 YOR184W SER1 0.4764 0.00009 0.4294 0.00002 0.3150 0.00008 YPR024W YME1 0.2942 0.00037 0.2608 0.00203 0.3263 0.00017 YDR477W SNF1 0.2626 0.00009 0.3186 0.00001 0.2766 0.00005 YPL158C AIM44 0.2431 0.00001 0.2696 0.00003 0.4340...”
- Selection markers for transformation of the sequenced reference monokaryon Okayama 7/#130 and homokaryon AmutBmut of Coprinopsis cinerea
Dörnte, Fungal biology and biotechnology 2020 - “...and THF Formyltetrahydrofolate deformylase PurU, THH46545 3-PHP to phosphoserine O -Phospho-L-serine:2-oxoglutarate aminotransferase SerC, THI65673 Ade9=Ser1, NP_014827 CC1G_11497T0 Chr_2:2,589,5692,588,293 L-serine to glycine+THF to 5,10-CH 2 -THF Glycine/serine hydroxymethyltransferase SHMT, 3G6M_A SHM2, NP_013159 CC1G_10328T0 Chr_6:1,087,9031,089,686 *Assigning classical linkage groups [ 50 52 ] and adenine auxotrophies [ 49...”
- A novel ER membrane protein Ehg1/May24 plays a critical role in maintaining multiple nutrient permeases in yeast under high-pressure perturbation
Kurosaka, Scientific reports 2019 - “...0.90.2 2.21.6 1.61.1 ARO2 YGL148W 4.00.1 0.20.0 0.40.0 2.60.4 0.30.1 0.30.0 0.70.1 1.30.3 0.70.1 SER1 YOR184W 4.20.1 0.90.3 0.80.2 3.80.5 1.00.1 0.90.2 0.90.1 1.20.4 1.20.5 TRP1 YDR007W 4.00.0 0.20.1 0.40.0 3.40.2 0.20.0 0.30.0 0.80.1 1.10.4 0.70.1 ARO1 YDR127W 3.80.2 0.10.0 0.50.0 2.40.2 0.20.0 0.30.1 0.60.0 1.10.1...”
- Phosphoserine Aminotransferase1 Is Part of the Phosphorylated Pathways for Serine Biosynthesis and Essential for Light and Sugar-Dependent Growth Promotion
Wulfert, Frontiers in plant science 2018 - “...the SERC gene from Escherichia coli , the CCDS6659 gene from Homo sapiens and the YOR184W gene from Saccharomyces cerevisiae were identified in the Arabidopsis thaliana genome (Figure 2 ). Homologous PSAT genes were further identified in the genome of all sequenced green plants present in...”
- Intracellular trafficking of the pyridoxal cofactor. Implications for health and metabolic disease
Whittaker, Archives of biochemistry and biophysics 2016 - “...2.3.1.50 Lcb2 YDR062W Bifunctional cysteine synthase/O-acetylhomoserine aminocarboxypropyltransferase 2.5.1.47 Met17 YLR303W 3-Phosphoserine aminotransferase PSAT 2.6.1.52 Ser1 YOR184W Serine hydroxymethyltransferase SHT 2.1.2.1 Shm2 YLR058C Branched-chain amino acid aminotransferase BCAT 2.6.1.42 Bat2 YJR148W -aminobutyrate (GABA) transaminase 2.6.1.19 Uga1 YGR019W 2-Aminoadipate transaminase AadAT 2.6.1.39 YER152C Ornithine decarboxylase ODC 4.1.1.17 Spe1...”
- Transcriptional profiling reveals molecular basis and novel genetic targets for improved resistance to multiple fermentation inhibitors in Saccharomyces cerevisiae
Chen, Biotechnology for biofuels 2016 - “...YKR080W, YLR058C, YLR142W , YLR180W, YLR231C, YLR303W, YMR169C , YMR189W, YMR300C, YNL135C, YNL160W, YOL058W, YOL086C, YOR184W, YOR375C YCL030C, YDR007W, YDR502C , YER091C , YGL245W, YGL256W , YJL200C, YJR016C, YLR142W , YMR169C , YMR250W YCL030C, YCR005C, YDL168W, YDL182W, YDR007W, YDR135C, YDR502C , YDR513W, YEL046C, YER043C, YER091C ,...”
- “...YER070W, YFL045C, YGR209C, YGR281W, YKR080W, YLR043C, YLR180W, YLR231C, YMR120C, YMR300C, YNL112W, YNL220W, YOL086C, YOR128C, YOR153W, YOR184W, YOR328W, YPL036W, YPL058C YCR021C , YDR502C, YGR043C, YGR256W, YKL151C, YLR249W, YMR105C, YOR128C, YPL036W YBL022C, YCR021C , YDL055C, YDR011W, YDR135C, YDR214W, YDR502C, YEL039C, YER043C, YFL037W, YGR043C, YGR209C, YGR256W, YGR281W, YKR080W, YLR180W,...”
- Systematic chemical-genetic and chemical-chemical interaction datasets for prediction of compound synergism
Wildenhain, Scientific data 2016 - “...filamentous growth, sensistive to many drugs S000000375 pdr1pdr3 Sensitized strain + + + + + YOR184W SER1 + ADE9 3-phosphoserine aminotransferase, catalyzes the formation of phosphoserine from 3-phosphohydroxypyruvate, required for serine and glycine biosynthesis; regulated by the general control of amino acid biosynthesis mediated by Gcn4p...”
- RSC Chromatin-Remodeling Complex Is Important for Mitochondrial Function in Saccharomyces cerevisiae
Imamura, PloS one 2015 - “...HOM2 HOMoserine requiring YER052C HOM3 HOMoserine requiring YJR139C HOM6 HOMoserine requiring YHL011C PRS3 PhosphoRibosylpyrophosphate Synthetase YOR184W SER1 SERine requiring YGR208W SER2 SERine requiring YCR053W THR4 THReonine requiring Carbohydrate YBR126C TPS1 Trehalose-6-Phosphate Synthase Transport Endosomal transport, YJL204C RCY1 ReCYcling protein targeting YDR137W RGP1 Reduced Growth Phenotype YLR039C...”
- More
ARB_04156 uncharacterized protein from Trichophyton benhamiae CBS 112371
36% identity, 80% coverage
MAC_05865 Phosphoserine transaminase from Metarhizium acridum
37% identity, 86% coverage
NCU01429 phosphoserine aminotransferase from Neurospora crassa OR74A
36% identity, 82% coverage
PAAG_03613 phosphoserine aminotransferase from Paracoccidioides lutzii Pb01
35% identity, 77% coverage
- Hemoglobin uptake by Paracoccidioides spp. is receptor-mediated
Bailão, PLoS neglected tropical diseases 2014 - “...G-protein comlpex beta subunit CpcB 1162.11 11.33 2.32 N.A. Regulation of amino acid metabolism 2 PAAG_03613 phosphoserine aminotransferase 265.03 8.67 4.35 2.6.1.52 Serine biosynthesis 2 PAAG_07760 threonine synthase 171.92 8.00 *** 4.2.3.1 Threonine biosynthesis 1 PAAG_08668 anthranilate synthase component 2 242.62 11.50 *** 4.1.3.27 Tryptophan biosynthesis...”
CSUI_009280 phosphoserine aminotransferase from Cystoisospora suis
43% identity, 56% coverage
- Unravelling the sexual developmental biology of Cystoisospora suis, a model for comparative coccidian parasite studies
Cruz-Bustos, Frontiers in cellular and infection microbiology 2023 - “...CSUI_003412, CSUI_001547), glutamine and glutamate (CSUI_010297, CSUI_10774, CSUI_10235, CSUI_003150), glycine and serine (CSUI_10078, CSUI_007993, CSUI_001515, CSUI_009280), proline (CSUI_001107, CSUI_000255), or tryptophan (CSUI_011414), as well as tyrosine transporters (CSUI_004056 and CSUI_006182). Our analysis identified 17 enzymes associated with purine and pyrimidine pathways ( Figure3 ; Tables2 ,...”
SCO4366 phosphoserine aminotransferase from Streptomyces coelicolor A3(2)
24% identity, 94% coverage
- Heterologous overproduction of oviedomycin by refactoring biosynthetic gene cluster and metabolic engineering of host strain Streptomyces coelicolor
Gu, Microbial cell factories 2023 - “...to three. The final three target reactions are mediated by phosphoserine transaminase (PSERT; encoded by SCO4366), methylenetetrahydrofolate dehydrogenase (MTHFD; encoded by SCO4824), and acetyl-CoA carboxylase (ACCOAC; encoded by SCO5535) (Fig. 3 a). These reactions are directly involved in the production of malonyl-CoA or NADPH, both of...”
- Rapid functional screening of Streptomyces coelicolor regulators by use of a pH indicator and application to the MarR-like regulator AbsC
Yang, Applied and environmental microbiology 2010 - “...11 9 2 Vitamin B6 metabolism SCO1523 SCO4293 SCO4366 Pyridoxine biosynthesis protein, YaaD Threonine synthase Phosphoserine aminotransferase 586 413 453 O O O 2...”
- “...B6 metabolism (SCO1523 [no. 453], SCO4293 [no. 414], and SCO4366 [no. 586]), and folate metabolism (SCO3401 [no. 474] and SCO4824 [no. 570]) were decreased in...”
- Lack of A-factor production induces the expression of nutrient scavenging and stress-related proteins in Streptomyces griseus
Birkó, Molecular & cellular proteomics : MCP 2009 - “...SCO6531 (83%), SAV1862 (84%) SCO5254 (87%), SAV2988 (86%) SCO4366 (87%), SAV3883 (87%) SCO4366 (87%), SAV3883 (87%) SCO6009 (78%), SAV2247 (77%) SCO6009 (78%),...”
C9YTK4 Phosphoserine aminotransferase from Streptomyces scabiei (strain 87.22)
23% identity, 92% coverage
MSMEG_5684 phosphoserine aminotransferase, putative from Mycobacterium smegmatis str. MC2 155
WP_003897096 phosphoserine transaminase from Mycolicibacterium smegmatis MC2 51
23% identity, 84% coverage
- MSMEG_5684 down-regulation in Mycobacterium smegmatis affects its permeability, survival under stress and persistence
Keshari, Tuberculosis (Edinburgh, Scotland) 2017 (PubMed)- “...metabolism. The Mycobacterium smegmatis mc2 155 ORF MSMEG_5684 is annotated as a part of serine biosynthetic pathway, however, its physiological significance...”
- “...smegmatis</ce:italic> mc<ce:sup loc="post">2</ce:sup> 155 ORF MSMEG_5684 is annotated as a part of serine biosynthetic pathway, however,...”
- High throughput screen identifies small molecule inhibitors specific for Mycobacterium tuberculosis phosphoserine phosphatase
Arora, The Journal of biological chemistry 2014 - “...BCG_0936c MMAR_4648 ML2136 MUL_0266 MAF_08930 MSMEG_5684, MSMEI_5534 MXEN_18904 Rv0728c BCG_0778c MMAR_1065 ML1837 (Pseudogene) MUL_0823 MAF_07380 Rv2996c...”
- MSMEG_5684 down-regulation in Mycobacterium smegmatis affects its permeability, survival under stress and persistence.
Keshari, Tuberculosis (Edinburgh, Scotland) 2017 (PubMed)- GeneRIF: Increased susceptibility to detergents, nitrosating and peroxide stress, increased inhibition in the presence of antimycobacterial agents and poor persisting behavior are manifestations of serC down-regulation in mycobacterium smegmatis.
BBIF_1428 phosphoserine transaminase from Bifidobacterium bifidum S17
24% identity, 93% coverage
- Proteomic Profiling of Bifidobacterium bifidum S17 Cultivated Under In Vitro Conditions
Wei, Frontiers in microbiology 2016 - “...Aminotransferase 522 58.1 BBIF_1100 argD Acetylornithine aminotransferase 429 45.4 BBIF_1175 bbif_1175 Aspartate aminotransferase 394 43.5 BBIF_1428 serC Phosphoserine aminotransferase 380 40.6 BBIF_1519 bbif_1519 N-succinyldiaminopimelate aminotransferase 392 41.5 BBIF_1610 aspC2 Aspartate aminotransferase 409 44.5 a aa, amino acids. b kDa, kilo Dalton. FIGURE 2 Enzymes of the...”
C629_RS05100 phosphoserine transaminase from Corynebacterium glutamicum SCgG2
22% identity, 85% coverage
cg0948 phosphoserine aminotransferase from Corynebacterium glutamicum ATCC 13032
22% identity, 85% coverage
CD16_RS00135 phosphoserine transaminase from Candidatus Liberibacter asiaticus
21% identity, 68% coverage
- Integrated bacterial transcriptome and host metabolome analysis reveals insights into "Candidatus Liberibacter asiaticus" population dynamics in the fruit pith of three citrus cultivars with different tolerance
Li, Microbiology spectrum 2024 - “...were also enriched in fruit pith of three cultivars, including 4-hydroxy-tetrahydrodipicolinate synthase (CD16_RS00745), phosphoserine transaminase (CD16_RS00135), UMP kinase (CD16_RS02145), guanylate kinase (CD16_RS05415), thymidylate synthase (CD16_RS04255), adenylosuccinate synthase (CD16_RS02965), type II toxin-antitoxin system RatA family toxin (CD16_RS02655), ferritin (CD16_RS02445), and superoxide dismutase (CD16_RS03555) ( Fig. 2B ;...”
MAB_0928c Putative phosphoserine aminotransferase from Mycobacterium abscessus ATCC 19977
23% identity, 83% coverage
MMAR_4648 phosphoserine aminotransferase SerC from Mycobacterium marinum M
23% identity, 91% coverage
MUL_0266 phosphoserine aminotransferase SerC from Mycobacterium ulcerans Agy99
24% identity, 91% coverage
2fyfA / P9WQ73 Structure of a putative phosphoserine aminotransferase from mycobacterium tuberculosis (see paper)
23% identity, 84% coverage
- Ligands: pyridoxal-5'-phosphate; tetrachloroplatinate(ii) (2fyfA)
ML2136 putative phosphoserine aminotransferase from Mycobacterium leprae TN
23% identity, 84% coverage
SERC_MYCTU / P9WQ73 Phosphoserine aminotransferase; Phosphohydroxythreonine aminotransferase; PSAT; EC 2.6.1.52 from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (see paper)
P9WQ73 phosphoserine transaminase (EC 2.6.1.52) from Mycobacterium tuberculosis (see paper)
Rv0884c phosphoserine aminotransferase from Mycobacterium tuberculosis H37Rv
NP_215399 phosphoserine aminotransferase from Mycobacterium tuberculosis H37Rv
BCG_0936c putative phosphoserine aminotransferase serC from Mycobacterium bovis BCG str. Pasteur 1173P2
24% identity, 82% coverage
- function: Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine.
catalytic activity: O-phospho-L-serine + 2-oxoglutarate = 3-phosphooxypyruvate + L-glutamate (RHEA:14329)
catalytic activity: 4-(phosphooxy)-L-threonine + 2-oxoglutarate = (R)-3-hydroxy-2- oxo-4-phosphooxybutanoate + L-glutamate (RHEA:16573)
cofactor: pyridoxal 5'-phosphate (Binds 1 pyridoxal phosphate per subunit.)
subunit: Homodimer. - Mycobacterium tuberculosis produces D-serine under hypoxia to limit CD8+ T cell-dependent immunity in mice
Cheng, Nature microbiology 2024 - “...conditions, remains unknown. Using metabolomic, proteomic and genetic approaches, here we show that Mtb induced Rv0884c (SerC), an Mtb phosphoserine aminotransferase, to produce d -serine. This activity increased Mtb pathogenesis in mice but did not directly affect intramacrophage Mtb survival. Instead, d -serine inhibited IFN- production...”
- “...by Mtb . Here we show that Mtb induces the expression of a phosphoserine aminotransferase, Rv0884c (SerC), to increase d -serine production under hypoxic conditions. d -serine suppresses CD8 + T cell-dependent interactions with macrophages and macrophage control of Mtb by inhibiting IFN- production. We provide...”
- Mycobacterium tuberculosis carbon and nitrogen metabolic fluxes
Xu, Bioscience reports 2022 - “...dehydratase (small subunit) (LeuD) Rv2987c Leucine biosynthesis (nitrogen metabolism) [ 78 ] Phosphoserine aminotransferase (SerC) Rv0884c Serine biosynthesis (nitrogen metabolism) [ 70 ] The table shows the participation of each enzyme and its respective genes in carbon and nitrogen metabolism. Deletion of these enzymes results in...”
- The unfoldase ClpC1 of Mycobacterium tuberculosis regulates the expression of a distinct subset of proteins having intrinsically disordered termini
Lunge, The Journal of biological chemistry 2020 (secret) - Intracellular Mycobacterium tuberculosis Exploits Multiple Host Nitrogen Sources during Growth in Human Macrophages
Borah, Cell reports 2019 - “...reaction using 3-phosphoglyceric acid (PGA) as the precursor produced during glycolysis. Phosphoserine transaminase ser C (Rv0884c) catalyzes the addition of nitrogen to the carbon backbone of pyruvate to form Ser ( Figure4 A; Bai etal., 2011 ). In addition to being a proteinogenic amino acid, Ser...”
- “...). Histograms of all FSRs are available in supplemental data file S4. Construction of serC (Rv0884c) knockout strain of H37Rv The knockout (KO) strain serC was constructed using the bacteriophage mediated transduction of wild-type H37Rv ( Bardarov etal., 2002 ). The strains and plasmid and primers...”
- Comparative proteomic analysis of sequential isolates of Mycobacterium tuberculosis from a patient with pulmonary tuberculosis turning from drug sensitive to multidrug resistant
Singh, The Indian journal of medical research 2015 - “...were hypothetical protein (Rv2004c), probable glutamyl-tRNA (GLN) amidotransferase A gatA (Rv3011c), possible phosphoserine aminotransferase SerC (Rv0884c), probable lipase/esterase LipN (Rv2970c), probable phosphoglycerate kinase Pgk (Rv1437), conserved hypothetical protein with FHA domain, GarA (Rv1827), bacterioferritin (Rv1876) and conserved hypothetical protein (Rv0543) and were not found in 2D-PAGE...”
- Mycobacterium tuberculosis H37Rv: In Silico Drug Targets Identification by Metabolic Pathways Analysis
Amir, International journal of evolutionary biology 2014 - “...33. Rv0728c D-3-phosphoglycerate dehydrogenase (EC: 1.1.1.95) Yes 34. Rv0505c Phosphoserine phosphatase (EC: 3.1.3.3) Yes 35. Rv0884c Phosphoserine aminotransferase (EC: 2.6.1.52) Yes 36. Rv0409 Acetate kinase (EC: 2.7.2.1) Yes 37. Rv0408 Phosphate acetyltransferase (EC: 2.3.1.8) Yes 38. Rv3667 Acetyl-CoA synthetase (EC: 6.2.1.1) Yes 39. Rv2611c Lipid A...”
- “...activity 32. Rv0505c Integral to plasma membrane Not Known Metal ion binding, phosphatase activity 33. Rv0884c Cytoplasm, extracellular region, plasma membrane L-serine biosynthetic process, growth, pyridoxine biosynthetic process O-phospho-L-serine: 2-oxoglutarate aminotransferase activity, pyridoxal phosphate binding 34. Rv0409 Cytoplasm Organic acid metabolic process ATP binding, acetate kinase...”
- HupB, a nucleoid-associated protein of Mycobacterium tuberculosis, is modified by serine/threonine protein kinases in vivo
Gupta, Journal of bacteriology 2014 - “...shift assay (EMSA). For the protein-DNA binding assay, Rv0884c promoter region (207bp) was end labeled with [-32P]ATP using T4 polynucleotide kinase (10 U/20-l...”
- “...(10 to 100 nM) and the promoter region of the Rv0884c gene. Notably, M. tuberculosis HupB and a shorter version of its N-terminal domain (1 to 95 amino acids...”
- Energetics of Respiration and Oxidative Phosphorylation in Mycobacteria
Cook, Microbiology spectrum 2014 - “...the narGHJI operon by anaerobic conditions in E. coli ( 21 ). A putative NarL (Rv0884c) has been indentifed in M. tuberculosis but the promoter of the narGHJI lacks consensus-like binding sites for this regulatory protein. Based on these observations, it is apparent that this enzyme...”
- More
- Structure of phosphoserine aminotransferase from Mycobacterium tuberculosis.
Coulibaly, Acta crystallographica. Section D, Biological crystallography 2012 (PubMed)- GeneRIF: Here, the 1.5 A resolution crystal structure of Mtb phosphoserine aminotransferase (MtbPSAT) in complex with its cofactor, pyridoxal 5'-phosphate (PLP), is reported.
- Dysregulation of serine biosynthesis contributes to the growth defect of a Mycobacterium tuberculosis crp mutant.
Bai, Molecular microbiology 2011 - GeneRIF: CRP binding directly activates both serC and Rv0885 expression.
- High throughput screen identifies small molecule inhibitors specific for Mycobacterium tuberculosis phosphoserine phosphatase
Arora, The Journal of biological chemistry 2014 - “...ML2424 MUL_4577 MAF_05120 MSMEG_0949 Rv0884c BCG_0936c MMAR_4648 ML2136 MUL_0266 MAF_08930 MSMEG_5684, MSMEI_5534 MXEN_18904 Rv0728c BCG_0778c MMAR_1065...”
CKC_05045 phosphoserine transaminase from Candidatus Liberibacter solanacearum CLso-ZC1
21% identity, 70% coverage
3ffrA Crystal structure of a phosphoserine aminotransferase serc (chu_0995) from cytophaga hutchinsonii atcc 33406 at 1.75 a resolution
24% identity, 59% coverage
For advice on how to use these tools together, see
Interactive tools for functional annotation of bacterial genomes.
The PaperBLAST database links 793,807 different protein sequences to 1,259,118 scientific articles. Searches against EuropePMC were last performed on March 13 2025.
PaperBLAST builds a database of protein sequences that are linked
to scientific articles. These links come from automated text searches
against the articles in EuropePMC
and from manually-curated information from GeneRIF, UniProtKB/Swiss-Prot,
BRENDA,
CAZy (as made available by dbCAN),
BioLiP,
CharProtDB,
MetaCyc,
EcoCyc,
TCDB,
REBASE,
the Fitness Browser,
and a subset of the European Nucleotide Archive with the /experiment tag.
Given this database and a protein sequence query,
PaperBLAST uses protein-protein BLAST
to find similar sequences with E < 0.001.
To build the database, we query EuropePMC with locus tags, with RefSeq protein
identifiers, and with UniProt
accessions. We obtain the locus tags from RefSeq or from MicrobesOnline. We use
queries of the form "locus_tag AND genus_name" to try to ensure that
the paper is actually discussing that gene. Because EuropePMC indexes
most recent biomedical papers, even if they are not open access, some
of the links may be to papers that you cannot read or that our
computers cannot read. We query each of these identifiers that
appears in the open access part of EuropePMC, as well as every locus
tag that appears in the 500 most-referenced genomes, so that a gene
may appear in the PaperBLAST results even though none of the papers
that mention it are open access. We also incorporate text-mined links
from EuropePMC that link open access articles to UniProt or RefSeq
identifiers. (This yields some additional links because EuropePMC
uses different heuristics for their text mining than we do.)
For every article that mentions a locus tag, a RefSeq protein
identifier, or a UniProt accession, we try to select one or two
snippets of text that refer to the protein. If we cannot get access to
the full text, we try to select a snippet from the abstract, but
unfortunately, unique identifiers such as locus tags are rarely
provided in abstracts.
PaperBLAST also incorporates manually-curated protein functions:
- Proteins from NCBI's RefSeq are included if a
GeneRIF
entry links the gene to an article in
PubMed®.
GeneRIF also provides a short summary of the article's claim about the
protein, which is shown instead of a snippet.
- Proteins from Swiss-Prot (the curated part of UniProt)
are included if the curators
identified experimental evidence for the protein's function (evidence
code ECO:0000269). For these proteins, the fields of the Swiss-Prot entry that
describe the protein's function are shown (with bold headings).
- Proteins from BRENDA,
a curated database of enzymes, are included if they are linked to a paper in PubMed
and their full sequence is known.
- Every protein from the non-redundant subset of
BioLiP,
a database
of ligand-binding sites and catalytic residues in protein structures, is included. Since BioLiP itself
does not include descriptions of the proteins, those are taken from the
Protein Data Bank.
Descriptions from PDB rely on the original submitter of the
structure and cannot be updated by others, so they may be less reliable.
(For SitesBLAST and Sites on a Tree, we use a larger subset of BioLiP so that every
ligand is represented among a group of structures with similar sequences, but for
PaperBLAST, we use the non-redundant set provided by BioLiP.)
- Every protein from EcoCyc, a curated
database of the proteins in Escherichia coli K-12, is included, regardless
of whether they are characterized or not.
- Proteins from the MetaCyc metabolic pathway database
are included if they are linked to a paper in PubMed and their full sequence is known.
- Proteins from the Transport Classification Database (TCDB)
are included if they have known substrate(s), have reference(s),
and are not described as uncharacterized or putative.
(Some of the references are not visible on the PaperBLAST web site.)
- Every protein from CharProtDB,
a database of experimentally characterized protein annotations, is included.
- Proteins from the CAZy database of carbohydrate-active enzymes
are included if they are associated with an Enzyme Classification number.
Even though CAZy does not provide links from individual protein sequences to papers,
these should all be experimentally-characterized proteins.
- Proteins from the REBASE database
of restriction enzymes are included if they have known specificity.
- Every protein with an evidence-based reannotation (based on mutant phenotypes)
in the Fitness Browser is included.
- Sequence-specific transcription factors (including sigma factors and DNA-binding response regulators)
with experimentally-determined DNA binding sites from the
PRODORIC database of gene regulation in prokaryotes.
- Putative transcription factors from RegPrecise
that have manually-curated predictions for their binding sites. These predictions are based on
conserved putative regulatory sites across genomes that contain similar transcription factors,
so PaperBLAST clusters the TFs at 70% identity and retains just one member of each cluster.
- Coding sequence (CDS) features from the
European Nucleotide Archive (ENA)
are included if the /experiment tag is set (implying that there is experimental evidence for the annotation),
the nucleotide entry links to paper(s) in PubMed,
and the nucleotide entry is from the STD data class
(implying that these are targeted annotated sequences, not from shotgun sequencing).
Also, to filter out genes whose transcription or translation was detected, but whose function
was not studied, nucleotide entries or papers with more than 25 such proteins are excluded.
Descriptions from ENA rely on the original submitter of the
sequence and cannot be updated by others, so they may be less reliable.
Except for GeneRIF and ENA,
the curated entries include a short curated
description of the protein's function.
For entries from BioLiP, the protein's function may not be known beyond binding to the ligand.
Many of these entries also link to articles in PubMed.
For more information see the
PaperBLAST paper (mSystems 2017)
or the code.
You can download PaperBLAST's database here.
Changes to PaperBLAST since the paper was written:
- November 2023: incorporated PRODORIC and RegPrecise. Many PRODORIC entries were not linked to a protein sequence (no UniProt identifier), so we added this information.
- February 2023: BioLiP changed their download format. PaperBLAST now includes their non-redundant subset. SitesBLAST and Sites on a Tree use a larger non-redundant subset that ensures that every ligand is represented within each cluster. This should ensure that every binding site is represented.
- June 2022: incorporated some coding sequences from ENA with the /experiment tag.
- March 2022: incorporated BioLiP.
- April 2020: incorporated TCDB.
- April 2019: EuropePMC now returns table entries in their search results. This has expanded PaperBLAST's database, but most of the new entries are of low relevance, and the resulting snippets are often just lists of locus tags with annotations.
- February 2018: the alignment page reports the conservation of the hit's functional sites (if available from from Swiss-Prot or UniProt)
- January 2018: incorporated BRENDA.
- December 2017: incorporated MetaCyc, CharProtDB, CAZy, REBASE, and the reannotations from the Fitness Browser.
- September 2017: EuropePMC no longer returns some table entries in their search results. This has shrunk PaperBLAST's database, but has also reduced the number of low-relevance hits.
Many of these changes are described in Interactive tools for functional annotation of bacterial genomes.
PaperBLAST cannot provide snippets for many of the papers that are
published in non-open-access journals. This limitation applies even if
the paper is marked as "free" on the publisher's web site and is
available in PubmedCentral or EuropePMC. If a journal that you publish
in is marked as "secret," please consider publishing elsewhere.
Many important articles are missing from PaperBLAST, either because
the article's full text is not in EuropePMC (as for many older
articles), or because the paper does not mention a protein identifier such as a locus tag, or because of PaperBLAST's heuristics. If you notice an
article that characterizes a protein's function but is missing from
PaperBLAST, please notify the curators at UniProt
or add an entry to GeneRIF.
Entries in either of these databases will eventually be incorporated
into PaperBLAST. Note that to add an entry to UniProt, you will need
to find the UniProt identifier for the protein. If the protein is not
already in UniProt, you can ask them to create an entry. To add an
entry to GeneRIF, you will need an NCBI Gene identifier, but
unfortunately many prokaryotic proteins in RefSeq do not have
corresponding Gene identifers.
References
PaperBLAST: Text-mining papers for information about homologs.
M. N. Price and A. P. Arkin (2017). mSystems, 10.1128/mSystems.00039-17.
Europe PMC in 2017.
M. Levchenko et al (2017). Nucleic Acids Research, 10.1093/nar/gkx1005.
Gene indexing: characterization and analysis of NLM's GeneRIFs.
J. A. Mitchell et al (2003). AMIA Annu Symp Proc 2003:460-464.
UniProt: the universal protein knowledgebase.
The UniProt Consortium (2016). Nucleic Acids Research, 10.1093/nar/gkw1099.
BRENDA in 2017: new perspectives and new tools in BRENDA.
S. Placzek et al (2017). Nucleic Acids Research, 10.1093/nar/gkw952.
The EcoCyc database: reflecting new knowledge about Escherichia coli K-12.
I. M. Keeseler et al (2016). Nucleic Acids Research, 10.1093/nar/gkw1003.
The MetaCyc database of metabolic pathways and enzymes.
R. Caspi et al (2018). Nucleic Acids Research, 10.1093/nar/gkx935.
CharProtDB: a database of experimentally characterized protein annotations.
R. Madupu et al (2012). Nucleic Acids Research, 10.1093/nar/gkr1133.
The carbohydrate-active enzymes database (CAZy) in 2013.
V. Lombard et al (2014). Nucleic Acids Research, 10.1093/nar/gkt1178.
The Transporter Classification Database (TCDB): recent advances
M. H. Saier, Jr. et al (2016). Nucleic Acids Research, 10.1093/nar/gkv1103.
REBASE - a database for DNA restriction and modification: enzymes, genes and genomes.
R. J. Roberts et al (2015). Nucleic Acids Research, 10.1093/nar/gku1046.
Deep annotation of protein function across diverse bacteria from mutant phenotypes.
M. N. Price et al (2016). bioRxiv, 10.1101/072470.
by Morgan Price,
Arkin group
Lawrence Berkeley National Laboratory