PaperBLAST
PaperBLAST Hits for tr|Q9HTD9|Q9HTD9_PSEAE alcohol dehydrogenase OS=Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) OX=208964 GN=adhA PE=1 SV=1 (342 a.a., MTLPQTMKAA...)
Show query sequence
>tr|Q9HTD9|Q9HTD9_PSEAE alcohol dehydrogenase OS=Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) OX=208964 GN=adhA PE=1 SV=1
MTLPQTMKAAVVHAYGAPLRIEEVKVPLPGPGQVLVKIEASGVCHTDLHAAEGDWPVKPP
LPFIPGHEGVGYVAAVGSGVTRVKEGDRVGIPWLYTACGCCEHCLTGWETLCESQQNTGY
SVNGGYAEYVLADPNYVGILPKNVEFAEIAPILCAGVTVYKGLKQTNARPGQWVAISGIG
GLGHVAVQYARAMGLHVAAIDIDDAKLELARKLGASLTVNARQEDPVEVLQRDIGGAHGV
LVTAVSNSAFGQAIGMARRGGTIALVGLPPGDFPTPIFDVVLKGLHIAGSIVGTRADLQE
ALDFAGEGLVKATIHPGKLDDINQILDQMRAGQIEGRIVLEM
Running BLASTp...
Found 250 similar proteins in the literature:
NP_254114 alcohol dehydrogenase from Pseudomonas aeruginosa PAO1
PA5427 alcohol dehydrogenase from Pseudomonas aeruginosa PAO1
MPAO1_28880 alcohol dehydrogenase AdhP from Pseudomonas aeruginosa
100% identity, 100% coverage
- Pseudomonas aeruginosa Ethanol Oxidation by AdhA in Low-Oxygen Environments.
Crocker, Journal of bacteriology 2019 - GeneRIF: This article is the first demonstration of a physiological role for AdhA in ethanol oxidation in low oxygen environments in P. aeruginosa.
- Distinct transcriptome and traits of freshly dispersed <i>Pseudomonas aeruginosa</i> cells
Kalia, mSphere 2024 - “...0.84785 Upregulated 0.761561 PA5366 ATP binding component of ABC phosphate transporter Upregulated 1.401961 Upregulated 0.735852 PA5427 Alcohol dehydrogenase 0.79947 Upregulated 0.06287 PA5490 cc4-cytochrome c4 precursor Upregulated 0.897352 Upregulated 0.531742 PA5495 Homoserine kinase 0.04312 Upregulated 0.320808 PA0027 Hypothetical protein Downregulated 1.14918 Downregulated 1.38885 PA0039 Hypothetical protein Downregulated...”
- Peptide 1018 inhibits swarming and influences Anr-regulated gene expression downstream of the stringent stress response in Pseudomonas aeruginosa
Wilkinson, PloS one 2021 - “...) carbamate kinase 4.6 NC PA5426 ( purE ) phosphoribosylaminoimidazole carboxylase catalytic subunit -2.1 -1.9 PA5427 ( adhA ) alcohol dehydrogenase 5.8 -1.8 PA5475 hypothetical protein 3.8 -2.5 Select genes encoding regulatory proteins implicated in virulence [ 35 ] PA0652 ( vfr ) cAMP-regulatory protein, virulence...”
- Cysteamine Inhibits Glycine Utilisation and Disrupts Virulence in Pseudomonas aeruginosa
Fraser-Pitt, Frontiers in cellular and infection microbiology 2021 - “...PA0997 pqsB Quorum sensing NP_253277.1 cytochrome C551 peroxidase PA4587 ccpR Oxidation-reduction processes NP_254114.1 alcohol dehydrogenase PA5427 adhA Ethanol detoxification NP_253754.1 phosphoribosyl-ATP pyrophosphatase PA5067 hisE Histidine biosynthesis NP_251985.1 HIT family protein PA3295 Uncharacterised NP_253563.1 OsmE family transcriptional regulator PA4876 osmE Response to stimulus NP_249102.1 twitching motility protein...”
- The Breadth and Molecular Basis of Hcp-Driven Type VI Secretion System Effector Delivery
Howard, mBio 2021 - “...2.02 d -2-Hydroxyglutarate dehydrogenase 51.3 PA1589 SucD 4.5 1.78 Succinate-CoA ligase (ADP-forming) subunit alpha 30.3 PA5427 AdhA 4.5 1.90 Alcohol dehydrogenase 35.9 PA2553 4.5 2.42 Probable acyl-CoA thiolase 41.4 PA4854 PurH 4.4 2.02 Bifunctional purine biosynthesis protein 57.7 PA2623 Icd 4.2 3.12 Isocitrate dehydrogenase (NADP) 45.6...”
- The extracytoplasmic function sigma factor σVreI is active during infection and contributes to phosphate starvation-induced virulence of Pseudomonas aeruginosa
Otero-Asman, Scientific reports 2020 - “...copper export protein 1.26 4.48 0.01063 PA5027 dadA Universal stress (UspA)-like protein 2.35 6.25 0.00587 PA5427 adhA Alcohol dehydrogenase 1.95 5.12 0.00587 PA5475 Unknown function, N-acetyltransferase domain 2.81 7.02 0.00587 PA0676 vreR Anti- factor 19 9.79 19.48 0.00587 PA0878 Unknown function 1.30 4.21 0.00587 PA2356 msuD...”
- Pseudomonas aeruginosa Ethanol Oxidation by AdhA in Low-Oxygen Environments
Crocker, Journal of bacteriology 2019 (secret) - Reorganization of gene network for degradation of polycyclic aromatic hydrocarbons (PAHs) in Pseudomonas aeruginosa PAO1 under several conditions
Yan, Journal of applied genetics 2017 - “...PA3240, PA3389, PA3629, PA3935, PA4091, PA4092, PA4121, PA4122, PA4123, PA4124, PA4125, PA4190, PA4486, PA4515, and PA5427. Gene network The genes with similar expression profiles are more likely (i) to encode interacting proteins, (ii) to have a similar biological function, and (iii) to belong to the same...”
- “...following PAH degradation genes (PA0865 and PA4091, PA1205 and PA2217, PA2512 and PA4122, PA2515 and PA5427) have the same profiles Figure 2 displays the genes together with PAH degradation genes in new clusters after exposure to sodium hypochlorite. Actually, this study used the same control as...”
- Transcriptomic Analyses Elucidate Adaptive Differences of Closely Related Strains of Pseudomonas aeruginosa in Fuel
Gunasekera, Applied and environmental microbiology 2017 - “...ID Genes related to energy metabolism PA2574 PA1525 PA5427 Gunasekera et al. Applied and Environmental Microbiology TABLE 2 Downregulation of genes encoding...”
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- An integrated model system to gain mechanistic insights into biofilm-associated antimicrobial resistance in Pseudomonas aeruginosa MPAO1
Varadarajan, NPJ biofilms and microbiomes 2020 - “...MPAO1_25230 DUF748 domain-containing protein 1.85 0.02 MPAO1_18000 ccoP Cytochrome-c oxidase, cbb3-type subunit III 1.60 0.05 MPAO1_28880 adhP Alcohol dehydrogenase AdhP 2.52 0.00 MPAO1_07010 Phosphoketolase 2.07 0.00 MPAO1_00100 LysM peptidoglycan-binding domain-containing protein 1.44 0.03 MPAO1_02290 TonB-dependent receptor 1.66 0.01 MPAO1_27435 Amino acid ABC transporter substrate-binding protein 3.09...”
PA14_71630 alcohol dehydrogenase, zinc-containing from Pseudomonas aeruginosa UCBPP-PA14
100% identity, 100% coverage
1lluA / Q9HTD9 The ternary complex of pseudomonas aeruginosa alcohol dehydrogenase with its coenzyme and weak substrate (see paper)
99% identity, 100% coverage
- Ligands: zinc ion; nicotinamide-adenine-dinucleotide; 1,2-ethanediol (1lluA)
RR42_RS34260 Alcohol dehydrogenase (EC 1.1.1.1) from Cupriavidus basilensis FW507-4G11
79% identity, 98% coverage
- mutant phenotype: Specifically important for utilizing Ethanol. Automated validation from mutant phenotype: the predicted function (ALCOHOL-DEHYDROG-RXN) was linked to the condition via a MetaCyc pathway. This annotation was also checked manually.
furX / Q46UZ9 furfuryl alcohol dehydrogenase (EC 1.1.1.1) from Cupriavidus pinatubonensis (strain JMP 134 / LMG 1197) (see paper)
78% identity, 99% coverage
3s2eA / Q46UZ9 Crystal structure of furx nadh complex 1
79% identity, 98% coverage
BCAM1570 alcohol dehydrogenase from Burkholderia cenocepacia J2315
75% identity, 99% coverage
- Burkholderia cenocepacia transcriptome during the early contacts with giant plasma membrane vesicles derived from live bronchial epithelial cells
Pimenta, Scientific reports 2021 - “...levels of B. cenocepacia K56-2 BCAM02418 , BCAM0729 , BCAL1829 , BCAL293 , BCAL3098 , BCAM1570 and BCAM2531 were obtained by qRT-PCR from bacteria adherent to 16HBE14o- cells and GPMVs (30min of contact). Results were normalized to expression of the housekeeping sigA gene. Expression levels are...”
- “...cells. In both cases, BCAM2418 , BCAM2531 , BCAL3098 and BCAL0729 genes are induced while BCAM1570 , BCAL2933 and BCAL1829 genes were found to be repressed. These results support that GPMVs may be an alternative model to study the early stages of host-bacteria interactions. Adherence to...”
- Understanding the Pathogenicity of Burkholderia contaminans, an Emerging Pathogen in Cystic Fibrosis
Nunvar, PloS one 2016 - “...38.5 7.3 23.6 hypothetical protein WR30_RS23460 BCAM1496 BMULJ_04253 3.6 1.5 1.4 alcohol dehydrogenase AdhA WR30_RS24145 BCAM1570 ortholog absent 106.2 2.4 21.7 TonB-dependent receptor WR30_RS24150 BCAM1571 BMULJ_04320 3.7 -2.5 3.7 Quorum sensing (QS) systems QS is known to regulate a multitude of functions that are involved in...”
- The unexpected discovery of a novel low-oxygen-activated locus for the anoxic persistence of Burkholderia cenocepacia
Sass, The ISME journal 2013 - “...of induction of these co-regulated non- lxa gene clusters varied from 3-fold (BCAM1494) to 86-fold (BCAM1570; Supplementary Table S4 ). They were not substantiatially activated under other growth conditions, however, upregulation greater than twofold was seen for: BCAM1249, BCAM148082 and BCAM1495 during stationary phase in minimal...”
- “...a Phosphate acetyl/butyryl transferase 116 BCAM0299 a Zinc-binding alcoholdehydrogenase 242 BCAM0312 a Polysaccharide deacetylase 46 BCAM1570 b Alcohol dehydrogenase 87 BCAM1581 Phosphoenolpyruvate carboxykinase 16 Storage polymer turnover BCAM0296 a Acetoacetyl-CoA reductase 94 BCAM0297 a Polyhydroxyalkanoic acid synthase, class I 224 BCAL1249 b Polyhydroxy butyrate depolymerase 42...”
- Response of Burkholderia cenocepacia H111 to micro-oxia
Pessi, PloS one 2013 - “...3.6 CCE47517 BCAM1250 Acetyl-CoA hydrolase 9.0 5.5 CCE47209 BCAM1537 Putative oxidoreductase YncB 6.0 9.4 CCE47172 BCAM1570 Alcohol dehydrogenase 4.7 7.6 CCE47153 BCAM1581 Phosphoenolpyruvate carboxykinase [GTP] 8.0 5.6 CCE46975 BCAM1734 Glucose dehydrogenase S 7.4 8.3 CCE53213 BCAM2093 Salicylate hydroxylase nd 28.5 CCE46457 BCAM2710 Protein acetyltransferase 19.5 1.9...”
MMB18_RS19225 alcohol dehydrogenase AdhP from Burkholderia contaminans
75% identity, 99% coverage
- Biofilm formation is correlated with low nutrient and simulated microgravity conditions in a Burkholderia isolate from the ISS water processor assembly
Diaz, Biofilm 2023 - “...MMB18_RS11700 3.49 1.58E-02 histidine utilization repressor hutC GO:0003700 MMB18_RS29270 2.47 2.36E-02 FadR family transcriptional regulator MMB18_RS19225 4.65 4.57E-03 alcohol dehydrogenase AdhP adhP MMB18_RS28595 3.76 6.91E-03 2-aminoethylphosphonate transporter substrate-binding proteinPhnS phnS GO:0055052 MMB18_RS24585 2.49 1.25E-02 glutamine--fructose-6-phosphate transaminase (isomerizing) glmS GO:0004360 MMB18_RS36430 4.37 1.36E-02 SulP family inorganic anion...”
- “...anion transporter GO:0016021 Stress response MMB18_RS33915 2.37 1.61E-02 toxin MMB18_RS36370 6.41 7.34E-03 universal stress protein MMB18_RS19225 6.45 4.69E-05 alcohol dehydrogenase AdhP adhP MMB18_RS36315 4.67 2.74E-02 efflux RND transporter periplasmic adaptor subunit NA #N/A Misc. MMB18_RS11485 2.91 3.59E-04 phasin family protein 3.5 Ersatz nutrient analysis The WPA...”
WR30_RS24145 alcohol dehydrogenase AdhP from Burkholderia contaminans FFH2055
75% identity, 99% coverage
BPSS1944 alcohol dehydrogenase from Burkholderia pseudomallei K96243
73% identity, 99% coverage
- GvmR - A Novel LysR-Type Transcriptional Regulator Involved in Virulence and Primary and Secondary Metabolism of Burkholderia pseudomallei
Duong, Frontiers in microbiology 2018 - “...and carbon metabolism. The complete F0F1 ATPase gene cluster (BPSS1945-1953) as well as the adhA (BPSS1944; alcohol dehydrogenase) located immediately downstream were upregulated in the gvmR mutant. Interestingly, the expression of the F0F1 ATPase-encoding gene cluster located on chromosome 1 (BPSL3394-3403) was not significantly affected by...”
- Transcriptional profiles of Burkholderia pseudomallei reveal the direct and indirect roles of Sigma E under oxidative stress conditions
Jitprasutwit, BMC genomics 2014 - “...NS 1.24 bpsl0327 LysR family regulatory protein NS 1.85 bpsl2289 IscS cysteine desulfurase NS 1.08 bpss1944 AdhA alcohol dehydrogenase NS 1.01 bpss1945 AtpG ATP synthase gamma chain NS 1.23 bpss1946 AtpA ATP synthase subunit A NS 1.24 NS; Not significant different. * B. pseudomallei cultured in...”
- The multiple roles of hypothetical gene BPSS1356 in Burkholderia pseudomallei
Yam, PloS one 2014 - “...prediction only], 36 kDa 9b BPSL3187 COG4266|Alc, Allantoicase [Nucleotide transport and metabolism], 37 kDa 9c BPSS1944 COG0202|RpoA, DNA-directed RNA polymerase, alpha subunit/40 kD subunit [Transcription], 36 kDa 10 BPSL3207 COG0092|RpsC, Ribosomal protein S3 [Translation, ribosomal structure and biogenesis], 30 kDa 11 N/A (Failed to be identified...”
- Adaptation and antibiotic tolerance of anaerobic Burkholderia pseudomallei
Hamad, Antimicrobial agents and chemotherapy 2011 - “...part of a genomic region spanning the genes BPSS1944 to BPSS1958 and includes genes encoding a putative alcohol dehydrogenase, a polymerase, an acetate kinase,...”
- “...California, Berkeley Arginine and pyruvate fermentation BPSS1711 BPSS1944 BPSL1743 BPSL1744 BPSL1745 BPSL1742 BPSS1956 Gene VOL. 55, 2011 ANTIBIOTIC TOLERANCE...”
IL54_0079 alcohol dehydrogenase AdhP from Sphingobium sp. ba1
74% identity, 99% coverage
HA399_02440 alcohol dehydrogenase AdhP from Cobetia sp. UIB-001
73% identity, 99% coverage
- "The Good, the Bad and the Double-Sword" Effects of Microplastics and Their Organic Additives in Marine Bacteria
Fernández-Juárez, Frontiers in microbiology 2020 - “...here when two proteins related to plastic degradation (alcohol dehydrogenase [ADH] of 342 amino acids, HA399_02440) and carbon transport (C4-dicarboxylate ABC transporter substrate-binding protein [C4-ABCS] of 329 amino acids, HA399_06715) were overproduced in the heterotroph Cobetia sp., but were not detectable with the MALDI-TOF analyses in...”
- “...et al., 2019 ). Figure 4 Structural analysis of alcohol dehydrogenase (ADH) from Cobetia sp. (HA399_02440). (A) Protein prediction of ADH showing, (B) the nicotinamide-adenine-dinucleotide (NAD) dependence, displaying the ligand binding residues HIS 43, THR 44, SER 174, GLY 175, GLY 177, GLY 178, LEU 179,...”
HELO_2818 alcohol dehydrogenase AdhP from Halomonas elongata DSM 2581
74% identity, 98% coverage
BAB1_0204 Zinc-containing alcohol dehydrogenase superfamily:Zinc-containing alcohol dehydrogenase from Brucella melitensis biovar Abortus 2308
Q2YP66 alcohol dehydrogenase from Brucella abortus (strain 2308)
BCAN_A0207 Alcohol dehydrogenase from Brucella canis ATCC 23365
72% identity, 99% coverage
3meqA / A0A0H3G9R2 Crystal structure of alcohol dehydrogenase from brucella melitensis
72% identity, 99% coverage
- Ligands: zinc ion; 1,4-dihydronicotinamide adenine dinucleotide (3meqA)
Pden_2367 Alcohol dehydrogenase GroES domain protein from Paracoccus denitrificans PD1222
72% identity, 99% coverage
BMEI1746 ALCOHOL DEHYDROGENASE from Brucella melitensis 16M
71% identity, 91% coverage
GME_RS00365 alcohol dehydrogenase AdhP from Halomonas sp. TD01
70% identity, 99% coverage
- Hyperproduction of 3-hydroxypropionate by Halomonas bluephagenesis
Jiang, Nature communications 2021 - “...Data 3 ). Several putative upregulated alcohol dehydrogenases were examined, including GME_RS01345, GME_05160, GME_RS01585 and GME_RS00365 encoding NAD(P)-dependent alcohol dehydrogenase (RefSeq. Accession: WP_009721539.1), zinc-binding alcohol dehydrogenase (GenBank Accession: EGP20677.1), zinc-binding dehydrogenase (RefSeq. Accession: WP_009721587.1), and alcohol dehydrogenase AdhP (RefSeq. Accession: WP_039868491.1), respectively (Fig. 2b ). Fig....”
- “...dehydrogenase, GME_RS01345 encodes NAD(P)-dependent alcohol dehydrogenase; GME_05160 encodes zinc-binding alcohol dehydrogenase, GME_RS01585 encodes zinc-binding dehydrogenase, GME_RS00365 encodes alcohol dehydrogenase AdhP. c 3HP production and d cell growth (DCM) and PHB content under optimal expression levels of aldehyde dehydrogenase. A stronger RBS was cloned instead of the...”
6z42A / E1V3M3 The low resolution structure of a zinc-dependent alcohol dehydrogenase from halomonas elongata.
72% identity, 99% coverage
ADH_MORSE / Q8GIX7 Alcohol dehydrogenase; ADH; EC 1.1.1.1 from Moraxella sp. (strain TAE123) (see 3 papers)
Q8GIX7 alcohol dehydrogenase (EC 1.1.1.1) from Moraxella sp. (see paper)
69% identity, 98% coverage
- function: Psychrophilic alcohol dehydrogenase that exhibits a wide range of substrate specificity, oxidizing mainly primary and secondary aliphatic alcohols, utilizing NAD(+) as a cosubstrate. In vitro, shows highest reaction rates for ethanol as a substrate and gradually decreases its reaction rates as the length and branching of the carbon chain of the alcohol substrates increase. To a lesser extent, is also able to reduce aldehydes and ketones. Do not catalyze the further oxidation of aldehydes to carboxylic acids. Cannot use NADP(+) instead of NAD(+).
catalytic activity: a primary alcohol + NAD(+) = an aldehyde + NADH + H(+) (RHEA:10736)
catalytic activity: a secondary alcohol + NAD(+) = a ketone + NADH + H(+) (RHEA:10740)
catalytic activity: ethanol + NAD(+) = acetaldehyde + NADH + H(+) (RHEA:25290)
catalytic activity: 1-propanol + NAD(+) = propanal + NADH + H(+) (RHEA:50704)
catalytic activity: butan-1-ol + NAD(+) = butanal + NADH + H(+) (RHEA:33199)
catalytic activity: propan-2-ol + NAD(+) = acetone + NADH + H(+) (RHEA:41984)
cofactor: Zn(2+) (Binds 2 Zn(2+) ions per subunit. One metal ion is located at the active-site region and has been termed catalytic, while the second metal ion has been termed structural.)
subunit: Homotetramer. - Structure and Dynamics of a Thermostable Alcohol Dehydrogenase from the Antarctic Psychrophile Moraxella sp. TAE123
Petratos, ACS omega 2020 - “...90 prokaryotic ADHs. 8 The ADH from the psychrophilic bacterium Moraxella sp. TAE123 (UniProtKB ID Q8GIX7) with an engineered hexahistidine tag at the carboxy terminus (hereafter Mo ADH) has been purified and crystallized, and the phases have been determined. 9 In the present work, the refined...”
- “...ADH (>40) Th ADH (>60) Mo ADH a 44.5 59.6 23.6 (PDB ID 4Z6K) (UniProtKB: Q8GIX7) Ec ADH:NAD + 1.28 54.1 24.1 (PDB ID 4GKV) (314) (UniProtKB: P39451) 1.46 (1195) Gs ADH:CF 3 CH 2 OH 0.70 1.33 25.9 (PDB ID 1RJW) (336) (311) (UniProtKB: P42328)...”
4z6kA / Q8GIX7 Alcohol dehydrogenase from the antarctic psychrophile moraxella sp. Tae 123
69% identity, 97% coverage
Q8L3C9 alcohol dehydrogenase (EC 1.1.1.1) from Flavobacterium frigidimaris (see paper)
66% identity, 99% coverage
6n7lC / A0A077EGR8 Crystal structure of an alcohol dehydrogenase from elizabethkingia anophelis nuhp1
68% identity, 99% coverage
- Ligands: nicotinamide-adenine-dinucleotide; zinc ion (6n7lC)
pRL90027 putative alcohol dehydrogenase from Rhizobium leguminosarum bv. viciae 3841
66% identity, 95% coverage
SMa1296 alcohol dehydrogenase AdhP from Sinorhizobium meliloti 1021
67% identity, 99% coverage
AAur_3063 Zn-dependent alcohol dehydrogenase from Arthrobacter aurescens TC1
A1R952 alcohol dehydrogenase from Paenarthrobacter aurescens (strain TC1)
65% identity, 99% coverage
Bdiaspc4_29865 alcohol dehydrogenase AdhP from Bradyrhizobium diazoefficiens
bll5655 alcohol dehydrogenase from Bradyrhizobium japonicum USDA 110
66% identity, 99% coverage
- An Integrated Systems Approach Unveils New Aspects of Microoxia-Mediated Regulation in Bradyrhizobium diazoefficiens
Fernández, Frontiers in microbiology 2019 - “...Bdiaspc4_27515 Co-chaperone GroES groES 1 blr5226 3.4 2.1 Bdiaspc4_29305 CBS domain-containing protein bll5551 1.1 2.0 Bdiaspc4_29865 Alcohol dehydrogenase AdhP adhP bll5655 2.8 18.0 3.9 + Bdiaspc4_30480 Efflux RND transporter permease subunit bll5771 3.8 2.6 Bdiaspc4_30485 Efflux RND transporter periplasmic adaptor subunit bll5772 4.0 3.5 Bdiaspc4_30510 DUF302...”
- An Integrated Systems Approach Unveils New Aspects of Microoxia-Mediated Regulation in Bradyrhizobium diazoefficiens
Fernández, Frontiers in microbiology 2019 - “...blr5226 3.4 2.1 Bdiaspc4_29305 CBS domain-containing protein bll5551 1.1 2.0 Bdiaspc4_29865 Alcohol dehydrogenase AdhP adhP bll5655 2.8 18.0 3.9 + Bdiaspc4_30480 Efflux RND transporter permease subunit bll5771 3.8 2.6 Bdiaspc4_30485 Efflux RND transporter periplasmic adaptor subunit bll5772 4.0 3.5 Bdiaspc4_30510 DUF302 domain-containing protein blr5777 4.3 5.0...”
- Characterization of a Functional Role of the Bradyrhizobium japonicum Isocitrate Lyase in Desiccation Tolerance
Jeon, International journal of molecular sciences 2015 - “...five translation-related genes (bll5381, bsl5382, bsl5391, bsl5392, and bll5397), five energy metabolism genes (bll3998, bll4784, bll5655, blr6128, and blr7040), four chaperonins (blr4637, blr4653, blr5625, and blr5626), one transport (bsr4636), one nitrogen fixation (blr2764), one regulatory gene (blr2475), and one chemotaxis (bll6865). Interestingly, there were 10 hypothetical...”
- Influence of elevated atmospheric carbon dioxide on transcriptional responses of Bradyrhizobium japonicum in the soybean rhizoplane
Sugawara, Microbes and environments 2013 - “...oxidation via a glutathione-dependent formaldehyde oxidation pathway. In addition, up-regulation of other alcohol dehydrogenase genes (bll5655, blr3675) in SFJ1436 was observed following exposure to elevated CO 2 ( Table 3 ). Rhizobia have previously been shown to grow using ethanol as the sole C source (...”
- “...blr3675 1.6 1.6 Putative alcohol dehydrogenase bll4784 1.5 Aldehyde dehydrogenase bll5504 1.5 Putative polyvinyl-alcohol dehydrogenase bll5655 * 1.6 2.6 Alcohol dehydrogenase blr6207 exaA 2.0 Quinoprotein ethanol dehydrogenase blr0335 1.5 Putative carbon monoxide dehydrogenase small chain bll5664 cooxM 2.3 Putative carbon monoxide dehydrogenase medium subunit Dicarboxylic acid...”
- Comprehensive assessment of the regulons controlled by the FixLJ-FixK2-FixK1 cascade in Bradyrhizobium japonicum
Mesa, Journal of bacteriology 2008 - “...Putative cytochrome b561 Unknown protein bsr5273 bll5315 bsr5316 bll5655 bll6061 bll6069 blr6070 bll6073 blr6074 blr6128 102.6 34.4 22.5 36.2 19.1 29.4 7.3 27.9...”
GOX0313 NAD-dependent alcohol dehydrogenase from Gluconobacter oxydans 621H
63% identity, 99% coverage
- Challenges in elucidating ethylene glycol metabolism in Saccharomyces cerevisiae
Senatore, FEMS yeast research 2025 (PubMed) (secret) - From plastic waste to bioprocesses: Using ethylene glycol from polyethylene terephthalate biodegradation to fuel <i>Escherichia coli</i> metabolism and produce value-added compounds
Balola, Metabolic engineering communications 2024 - “...EG oxidative pathway, FucO and AldA, except for the study by Yan et al. where Gox0313 is used instead of FucO. Abbreviations: EG, ethylene glycol; CSM, Complete Supplement mixture; P_gyrA, promoter gyrA; FucO, propanediol oxidoreductase; FucO I7L/L8V , propanediol oxidoreductase mutant I7L/L8V; AldA, glycolaldehyde dehydrogenase. Table...”
- “...Yan et al. (2024) Production of glycolate from EG E. coli MG1655 fucO yqhD expressing Gox0313 (instead of FucO) and AldA under trc promoter in high copy number plasmid pTrc99a Glycolate production performed in shake flasks M9 minimal medium with 10g/L EG supplemented with 2g/L yeast...”
- Biotransformation of ethylene glycol by engineered <i>Escherichia coli</i>
Yan, Synthetic and systems biotechnology 2024 - “...This study pEc01002 pET-28a (+): PQQ-PedE This study pEc01003 pTrc99a: fucO This study pEc01004 pTrc99a: Gox0313 This study pEc01005 pTrc99a: Gox0313-aldA This study 2.2 Plasmids construction All plasmids used in this study are shown in Table 1 . The codon was optimized with E . coli...”
- “...Eco RI double restriction endonuclease and T4 connection to obtain the engineered plasmid pEc01003. The Gox0313 gene and plasmid vector pTrc99a were digested by Bam HI and Eco RI and combined with T4 to obtain the engineered plasmid pEc01004. The aldA gene fragment was obtained from...”
- Exploring yeast biodiversity and process conditions for optimizing ethylene glycol conversion into glycolic acid
Senatore, FEMS yeast research 2024 - “...Gluconobacter oxydans , which is able to catalyse the oxidation of EG to GAH with Gox0313, a NAD + -dependent alcohol dehydrogenase (Zhang et al. 2015 ). To the best of our knowledge, EG oxidation to GA has been reported in yeast only by two works,...”
- FNR-Type Regulator GoxR of the Obligatorily Aerobic Acetic Acid Bacterium Gluconobacter oxydans Affects Expression of Genes Involved in Respiration and Redox Metabolism
Schweikert, Applied and environmental microbiology 2021 - “...which was activated by GoxR. The pnt operon encodes a transhydrogenase (pntA1A2B), an NADH-dependent oxidoreductase (GOX0313), and another oxidoreductase (GOX0314). Evidence was obtained for GoxR being active despite a high dissolved oxygen concentration in the medium. We suggest a model in which the very high respiration...”
- “...enhances fast interconversion of NADPH and NADH by the transhydrogenase and NADH reoxidation by the GOX0313 oxidoreductase via reduction of acetaldehyde formed by pyruvate decarboxylase to ethanol. In fact, small amounts of ethanol were formed by G. oxydans under oxygen-restricted conditions in a GoxR-dependent manner.IMPORTANCEGluconobacter oxydans...”
- Degradation of the low-calorie sugar substitute 5-ketofructose by different bacteria
Schiessl, Applied microbiology and biotechnology 2021 - “...(Schweiger et al. 2008 ) Escherichia coli pASK5_gox0313 E. coli NEB 5-alpha containing plasmid pASK5_ gox0313 (Schweiger et al. 2013 ) Escherichia coli pASK3_gox0646 E. coli NEB 5-alpha containing plasmid pASK3_ gox0646 (Schweiger et al. 2013 ) Escherichia coli pASK5_gox1417 E. coli NEB 5-alpha containing plasmid...”
- “...from G. oxydans 621H hsdR (Schweiger et al. 2008 ) pASK5_gox0313 pASK-IBA.5 containing the gene gox0313 from G. oxydans 621H hsdR (Schweiger et al. 2013 ) pASK3_gox0646 pASK-IBA.3 containing the gene gox0646 from G. oxydans 621H hsdR (Schweiger et al. 2013 ) pASK5_gox0417 pASK-IBA.5 containing the...”
- Current Advances in the Biodegradation and Bioconversion of Polyethylene Terephthalate
Qi, Microorganisms 2021 - “...yield of 92.9% within 45 h [ 122 ]. Two genes encoding recombinant cytosolic oxidoreductases (gox0313 and gox0646) from G. oxydans were heterologously expressed in E. coli and the resulting proteins were purified and characterized [ 123 ]. In addition to G. oxydans , engineered E....”
- Ketoreductase TpdE from Rhodococcus jostii TMP1: characterization and application in the synthesis of chiral alcohols
Stankevičiūtė, PeerJ 2015 - “...other enzymes active towards vicinal diketones including aldoketo reductase AKR3C1 from Saccharomyces cerevisiae , oxidoreductase GOX0313 from Gluconobacter oxydans and acetoin(diacetyl) reductase from Rhodococcus erythropolis WZ010 ( Calam et al., 2013 ; Schweiger et al., 2013 ; Wang et al., 2014 ). While the bioconversion of...”
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APA386B_1507 alcohol dehydrogenase AdhP from Acetobacter pasteurianus 386B
63% identity, 98% coverage
- Complete genome sequence and comparative analysis of Acetobacter pasteurianus 386B, a strain well-adapted to the cocoa bean fermentation ecosystem
Illeghems, BMC genomics 2013 - “...acetate is formed out of ethanol by soluble, NAD(P) + -dependent ADH ( adh ; APA386B_1507; Figure 4 , reaction 34) and ALDH (APA386B_909; Figure 4 , reaction 35) intracellularly, or out of lactate by means of a lactate dehydrogenase ( ldh ; APA386B_910; Figure 4...”
- “...and APA386B_2736); (32) dihydrolipoamide dehydrogenase (APA386B_2735 and APA386B_2271); (33) pyruvate decarboxylase (APA386B_1186); (34) alcohol dehydrogenase (APA386B_1507, APA386B_2362, and APA386B_496); (35) aldehyde dehydrogenase (APA386B_909); (36) acetyl-CoA synthetase (APA386B_1843 and APA386B_2214); (37) acetate kinase (APA386B_335); (38) phosphate acetyltransferase (APA386B_336); (39) malate dehydrogenase (APA386B_1600); (40) aconitate hydratase 1 (APA386B_1323);...”
APA01_00250 alcohol dehydrogenase from Acetobacter pasteurianus IFO 3283-01
63% identity, 98% coverage
F1542_05850 alcohol dehydrogenase AdhP from Komagataeibacter sp. FXV3
62% identity, 98% coverage
ACIAD3339 alcohol dehydrogenase from Acinetobacter sp. ADP1
63% identity, 98% coverage
- Characterization of a novel β-alanine biosynthetic pathway consisting of promiscuous metabolic enzymes
Perchat, The Journal of biological chemistry 2022 - “...activity ( Table1 ). Based on these data, ACIAD0960 (GabD-like), ACIAD1009 (BetB), ACIAD2018 (acoD), and ACIAD3339 (AdhA) were purified (see the Experimental procedures section and Fig.S2 ) and kinetically characterized ( Table2 ). ACoD and AdhA were specific for NAD + , whereas GabD-like and BetB...”
- “...betaine aldehyde dehydrogenase 1.80 0.02 b ACIAD2018 acoD Acetaldehyde dehydrogenase II (ACDH-II) 5.71 0.06 b ACIAD3339 adhA Alcohol dehydrogenase 1.99 0.03 b Activities reported represent the greater value obtained with either 2mM NADP + or NAD + . a Value obtained with NADP + . b...”
- iTRAQ-Based Comparative Proteomic Analysis of Acinetobacter baylyi ADP1 Under DNA Damage in Relation to Different Carbon Sources
Jiang, Frontiers in microbiology 2019 - “...4.21 2.38 2.07 2.78 Malate dehydrogenase mdh ACIAD3155 1.77 1.49 2.65 1.8 Alcohol dehydrogenase adhA ACIAD3339 6.73 18.54 10 7.73 Fatty acyl-CoA reductase acr1 ACIAD3383 1.47 2.68 1.87 2.29 ssDNA exonuclease, 5 > 3 specific, Mg dependent recJ ACIAD3500 1.61 1.32 1.6 1.46 Pyruvate dehydrogenase (acetyl-transferring),...”
Q6RS93 alcohol dehydrogenase (EC 1.1.1.1) from Parageobacillus thermoglucosidasius (see paper)
63% identity, 98% coverage
P42328 alcohol dehydrogenase (EC 1.1.1.1) from Geobacillus stearothermophilus (see 8 papers)
1rjwA / P42328 Crystal structure of NAD(+)-dependent alcohol dehydrogenase from bacillus stearothermophilus strain lld-r (see paper)
62% identity, 98% coverage
- Ligands: zinc ion; trifluoroethanol (1rjwA)
- Identification and characterization of a novel formaldehyde dehydrogenase in Bacillus subtilis
Klein, Applied and environmental microbiology 2024 - “...Saccharolobus solfataricus (GenBank ID: P39462) ( 57 ); GsAHD, Adh from Geobacillus stearothermophilus (GenBank ID: P42328) ( 58 ); BsBSH-FDH, bacilithiol-dependent Fdh from B. subtilis (GenBank ID: NP_390579) ( 26 ); CbADH, Adh from Clostridium beijerinckii (GenBank ID: P25984) ( 59 ); TbADH, Adh from Thermoanaerobacter...”
- Generation of Oxidoreductases with Dual Alcohol Dehydrogenase and Amine Dehydrogenase Activity
Tseliou, Chemistry (Weinheim an der Bergstrasse, Germany) 2021 - “...from horse liver (UniProt P00327), [8] yeast (P00330),[ 8a , 9 ] Bacillus stearothermophilus (UniProt P42328, PDB 1RJW; 3PII), [10] Sulfolobus solfataricus (UniProt P39462, PDB 1R37), [11] Acinetobacter calcoaceticus (UniProt Q59096, PDB 1F8F), [12] and Thermoanaerobacter brockii (also named as Thermoanaerobacter ethanolicus , UniProt P14941, PDB...”
- Structure and Dynamics of a Thermostable Alcohol Dehydrogenase from the Antarctic Psychrophile Moraxella sp. TAE123
Petratos, ACS omega 2020 - “...coli ( Ec ADH, UniProtKB ID P39451), 12 Geobacillus stearothermophilus ( Gs ADH, UniProtKB ID P42328), 13 and Thermus sp. ATN1 ( Th ADH, UniProtKB ID B2ZRE3). 14 Moreover, circular dichroism (CD) spectropolarimetry and enzyme kinetics of Mo ADH have been carried out at varying temperatures....”
- “...Gs ADH:CF 3 CH 2 OH 0.70 1.33 25.9 (PDB ID 1RJW) (336) (311) (UniProtKB: P42328) 0.75 1.51 (1347) (1176) Th ADH:NAD + 1.56 1.60 1.59 (PDB ID 4CPD) (264) (271) (271) (UniProtKB: B2ZRE3) 1.78 1.94 1.76 (913) (715) (915) a The right diagonal half of...”
ABC0046 alcohol dehydrogenase from Bacillus clausii KSM-K16
59% identity, 97% coverage
Geoth_3823 alcohol dehydrogenase AdhP from Parageobacillus thermoglucosidasius C56-YS93
59% identity, 98% coverage
6iqdA / P42327 Crystal structure of alcohol dehydrogenase from geobacillus stearothermophilus (see paper)
59% identity, 98% coverage
adhA / Q8NLX9 Zn2+-dependent alcohol dehydrogenase (EC 1.1.1.1; EC 1.1.1.244) from Corynebacterium glutamicum (strain ATCC 13032 / DSM 20300 / BCRC 11384 / JCM 1318 / LMG 3730 / NCIMB 10025) (see 5 papers)
NCgl2709 alcohol dehydrogenase AdhP from Corynebacterium glutamicum ATCC 13032
cg3107 Zn-dependent alcohol dehydrogenase from Corynebacterium glutamicum ATCC 13032
57% identity, 98% coverage
- Vanillin production by Corynebacterium glutamicum using heterologous aromatic carboxylic acid reductases
Matsuzawa, Biotechnology for biofuels and bioproducts 2024 - “...vanABK (FKS0165) This work C. glutamicum 2256 vanABK NCgl0313 This work C. glutamicum 2256 vanABK NCgl2709 This work C. glutamicum 2256 vanABK NCgl0324 This work C. glutamicum 2256 vanABK NCgl2709 NCgl0324 This work C. glutamicum 2256 vanABK NCgl0313 NCgl2709 This work C. glutamicum 2256 vanABK NCgl0313...”
- “...8 ]. Our parent strain C. glutamicum 2256 had three AAR homologs (NCgl0313, NCgl0324, and NCgl2709). Therefore, to obtain a strain that has completely lost AAR activity, strains lacking one, two, or all three genes were constructed and grown in the presence of 1g/L vanillin, and...”
- Engineered Corynebacterium glutamicum as the Platform for the Production of Aromatic Aldehydes
Kim, Frontiers in bioengineering and biotechnology 2022 - “...and P99/P100 for NCgl2449 , P103/P104 and P105/P106 for NCgl2582 , P109/P110 and P111/P112 for NCgl2709 , and P115/P116 and P117/P118 for NCgl2952 . The two amplified fragments of each gene were cloned into pK19 mobsacB / Hin dIII/ Eco RI using Gibson assembly, resulting in...”
- “...C. glutamicum genome. Ten proteins, that is, NCgl0219, NCgl0313, NCgl0324, NCgl0503, NCgl1003, NCgl1112, NCgl2053, NCgl2277, NCgl2709, and NCgl2952 were classified as candidates that showed a BLASTP expect value less than E 20 . Likewise, three ADHs, that is, NCgl0219, NCgl0324, and NCgl2709 were chosen using ADH6...”
- Understanding the high L-valine production in Corynebacterium glutamicum VWB-1 using transcriptomics and proteomics
Zhang, Scientific reports 2018 - “...5.16/36045.54 3209.93 938.70 8.3 51 NCgl1526 cg1791 gap Glyceraldehyde-3-phosphate dehydrogenase 5.16/36045.54 0.00 4006.09 8.3 53 NCgl2709 cg3107 adhA Zn-dependent alcohol dehydrogenase 5.23/36811.85 5992.18 0.00 66.7 61 NCgl0670 cg0802 accBC Biotin carboxylase and carboxyl carrier protein 5.02/63419.65 710.24 0.00 5.1 63 NCgl2698 cg3096 ald Aldehyde dehydrogenase 4.96/55106.23...”
- Complex regulation of the phosphoenolpyruvate carboxykinase gene pck and characterization of its GntR-type regulator IolR as a repressor of myo-inositol utilization genes in Corynebacterium glutamicum
Klaffl, Journal of bacteriology 2013 - “...cg3195 cg3216 NCgl2248 NCgl2399 NCgl2698 NCgl2709 NCgl2765 NCgl2787 NCgl2808 myo-Inositol catabolism, carbohydrate kinase Hypothetical protein myo-Inositol...”
- Citrate utilization by Corynebacterium glutamicum is controlled by the CitAB two-component system through positive regulation of the citrate transport genes citH and tctCBA
Brocker, Journal of bacteriology 2009 - “...NCgl2565 NCgl2476 NCgl2477 NCgl2656 NCgl2657 NCgl0805 NCgl1368 NCgl2294 NCgl2709 NCgl2787 Gene name citA citB tctA tctB tctC citH ssuD1 ssuC ssuB ssuA lldD rpsF...”
- The DeoR-type transcriptional regulator SugR acts as a repressor for genes encoding the phosphoenolpyruvate:sugar phosphotransferase system (PTS) in Corynebacterium glutamicum
Gaigalat, BMC molecular biology 2007 - “...IIBCA component cg2120 NCgl1861 ptsF 3.27 12.04 Phosphotransferase system (PTS), fructose-specific enzyme IIABC component cg3107 NCgl2709 adhA 3.23 13.00 Alcohol dehydrogenase cg2118 NCgl1859 - 3.00 12.00 Transcriptional regulator protein, DeoR-family cg1537 NCgl1305 ptsG 2.70 11.97 Phosphotransferase system (PTS), glucose-specific enzyme IIBCA component cg2119 NCgl1860 fruK 2.67...”
- Adaptation of Corynebacterium glutamicum to ammonium limitation: a global analysis using transcriptome and proteome techniques
Silberbach, Applied and environmental microbiology 2005 - “...0.43 0.33 NCgl2112 NCgl2437 NCgl2673 NCgl2247 NCgl2248 NCgl2709 pepB glnD glnK cgtR3 cgtS10 argR Annotation Putative regulatory protein (WhiB-related protein)...”
- Bacterial zinc uptake regulator proteins and their regulons
Mikhaylina, Biochemical Society transactions 2018 - “...genes differentially regulated in mutant 2 znuABC cg0794 ( yciC ) cg0795 ( oxidoreductase ) cg3107 ( adhA ) cg0040 (secreted protein) zrf (CDF effluxer) zra (ATPase) [ 67 , 72 ] Corynebacterium diphtheriae Zur mutant, qRT-PCR, reporter assays troABC zrg ( yciC ) adhA Several...”
- Understanding the high L-valine production in Corynebacterium glutamicum VWB-1 using transcriptomics and proteomics
Zhang, Scientific reports 2018 - “...3209.93 938.70 8.3 51 NCgl1526 cg1791 gap Glyceraldehyde-3-phosphate dehydrogenase 5.16/36045.54 0.00 4006.09 8.3 53 NCgl2709 cg3107 adhA Zn-dependent alcohol dehydrogenase 5.23/36811.85 5992.18 0.00 66.7 61 NCgl0670 cg0802 accBC Biotin carboxylase and carboxyl carrier protein 5.02/63419.65 710.24 0.00 5.1 63 NCgl2698 cg3096 ald Aldehyde dehydrogenase 4.96/55106.23 1004.77...”
- Identification of two mutations increasing the methanol tolerance of Corynebacterium glutamicum
Leßmeier, BMC microbiology 2015 - “...pathway, the oxidation of methanol to formaldehyde is mainly performed by the alcohol dehydrogenase AdhA (cg3107), but at least one additional enzyme of hitherto unknown identity is also involved [ 20 ]. Formaldehyde is oxidized by two distinct enzymes, the acetaldehyde dehydrogenase Ald (cg3096) and the...”
- “...glutamicum WT carrying the vector pVWEx1 This study adhA in-frame deletion of the adhA gene (cg3107) of C. glutamicum WT [ 21 ] ramA in-frame disruption of the ramA gene (cg2831) of C. glutamicum WT [ 55 ] T0198 point mutation cg0198 A19V from strain Tol1...”
- Metabolic engineering of Corynebacterium glutamicum for methanol metabolism
Witthoff, Applied and environmental microbiology 2015 - “...DNA on standard vectors (Life Technologies). The adhA gene (cg3107) was amplified from genomic DNA of C. glutamicum ATCC 13032 by PCR. The genes yckG (here hps)...”
- C1 metabolism in Corynebacterium glutamicum: an endogenous pathway for oxidation of methanol to carbon dioxide
Witthoff, Applied and environmental microbiology 2013 - “...(see Table S1). The coding regions of adhA (cg3107), ald (cg3096), and adhE (cg0387) were amplified by PCR using the oligonucleotide pairs P_adhA_fw_NdeI/P_...”
- “...glutamicum were among the upregulated genes: adhA (cg3107; 4.4-fold), encoding an alcohol dehydrogenase (11, 43), and ald (cg3096; 2.1-fold), encoding...”
- Complex regulation of the phosphoenolpyruvate carboxykinase gene pck and characterization of its GntR-type regulator IolR as a repressor of myo-inositol utilization genes in Corynebacterium glutamicum
Klaffl, Journal of bacteriology 2013 - “...NCgl0900 NCgl1353 NCgl1650 iolC cg2560 cg2732 cg3096 cg3107 cg3169 cg3195 cg3216 NCgl2248 NCgl2399 NCgl2698 NCgl2709 NCgl2765 NCgl2787 NCgl2808 myo-Inositol...”
- The Zur regulon of Corynebacterium glutamicum ATCC 13032
Schröder, BMC genomics 2010 - “...cg0042 - cg0043 intergenic region and in front of cg0794, cg0795 , cg2911 , and cg3107 . DNA band shift assays were performed with 40 pmol of streptavidin-tagged Zur protein incubated with 0.05 pmol of fluorescein-labeled, double-stranded 40-mer DNA fragments. The assays were performed in the...”
- “...candidate Zur-binding site was detected by cross-genome comparisons in the upstream region of adhA ( cg3107 ), but the purified Zur protein did not bind to a corresponding 40-mer DNA sequence in vitro . In addition, the adhA gene was not detected as differentially expressed in...”
- Engineering Corynebacterium glutamicum for isobutanol production
Smith, Applied microbiology and biotechnology 2010 - “...and Spe I and ligating into pKS152 cut with the same restriction enzymes. adhA ( Cg3107) of C. glutamicum was amplified from genomic DNA using primers K887 and K888, and the PCR product was digested with Spe I and ligated into pKS154 cut with the same...”
- More
DIP2114 alcohol dehydrogenase from Corynebacterium diphtheriae NCTC 13129
59% identity, 98% coverage
- Identification of zinc and Zur-regulated genes in Corynebacterium diphtheriae
Peng, PloS one 2019 - “...predicted to encode large sortase-anchored surface proteins of unknown function. Expression of the adhA ( dip2114 ) gene, predicted to encode an alcohol dehydrogenase, was activated by Zur in the presence of zinc, suggesting that Zur not only functions as a repressor but also as a...”
- “...surface-anchored membrane protein -5.35 5.62 dip_RS20265 hypothetical protein -2.39 -1.01 dip1834 hypothetical protein -2.23 -1.29 dip2114 AdhA alcohol dehydrogenase 3.39 -3.32 dip2125 ABC transporter ATP-binding protein -1.53 2.37 dip2126 peptide ABC transporter permease -1.47 2.09 dip2127 ABC transporter permease -1.67 2.23 dip2128 substrate-binding transport protein -2.07...”
- Development and use of a selectable, broad-host-range reporter transposon for identifying environmentally regulated promoters in bacteria
Spinler, FEMS microbiology letters 2009 - “...DtxR-regulated genes dip0109 / irp 6A ( Qian, Lee et al . 2002 ) and dip2114 / adh A ( Kunkle and Schmitt 2003 ), whereas three other mutants have insertions in genes that were not previously shown to be iron regulated ( dip0620/fol D, dip0785/glt...”
- “...iron- and DtxR-repressible genes, dip0109/irp 6A ( Qian, Lee et al . 2002 ) and dip2114 / adh A ( Kunkle and Schmitt 2003 ). Recovery of these integrants validates the use of Tn KnXSp for mutational analysis of iron-regulated promoters in C. diphtheriae. The other...”
- The alcohol dehydrogenase gene adhA in Corynebacterium glutamicum is subject to carbon catabolite repression
Arndt, Journal of bacteriology 2007 - “...Corynebacterium diphtheriae NCTC 13129 (GenBank accession no. DIP2114), showing identities of 72% and 74%, respectively, whereas no significant similarities to...”
CE0053 putative alcohol dehydrogenase from Corynebacterium efficiens YS-314
55% identity, 98% coverage
CCI6_RS16285 zinc-dependent alcohol dehydrogenase from Frankia sp. CcI6
Francci3_2945 Alcohol dehydrogenase, zinc-binding from Frankia sp. CcI3
53% identity, 98% coverage
- Genomic, transcriptomic, and proteomic approaches towards understanding the molecular mechanisms of salt tolerance in Frankia strains isolated from Casuarina trees
Oshone, BMC genomics 2017 - “...Clp protease proteolytic subunit ClpP 23,039.30 4.79 [R] General Functional Prediction only CcI6 16 563,312,796 CCI6_RS16285 Zn-dependent alcohol dehydrogenase 35,062.50 5.65 N/C CcI3 7 WP_011434678.1 FRANCCI3_RS01050 FMN reductase 21,222.1 5.3 Not assigned to COG categories CcI6 4 563,313,603 CCI6_RS12255 Nitroreductase 37,351.40 4.90 12 563,313,563 CCI6_RS12810 proteasome...”
- Transcriptomes of Frankia sp. strain CcI3 in growth transitions
Bickhart, BMC microbiology 2011 - “...1161 cold-shock DNA-binding Francci3_4469 2949 putative DNA-binding Francci3_1949 1392 GDP-mannose 4,6-dehydratase Francci3_1307 1134 Alcohol dehydrogenase Francci3_2945 2916 LuxR family regulator Francci3_0765 1361 hypothetical protein Francci3_4023 1122 putative Lsr2-like protein Francci3_3498 2659 chaperoninGroEL Francci3_4398 1199 major facilitator superfamily Francci3_2289 1122 hypothetical protein Francci3_1936 2577 hypothetical protein Francci3_4123...”
- “...1596 hypothetical protein Francci3_4114 821 CRISPR-associated protein Francci3_3345 863 alanine dehydrogenase/PNT-like Francci3_2946 1532 Alcohol dehydrogenase Francci3_2945 796 glycosyl transferase Francci3_3318 859 serine phosphatase Francci3_3249 1453 hypothetical protein Francci3_3791 782 metallophosphoesterase Francci3_1990 839 chaperonin GroEL Francci3_0633 1439 acyl-CoA dehydrogenase Francci3_1000 781 hypothetical protein Francci3_3339 837 hypothetical protein...”
SCO0199 alcohol dehydrogenase from Streptomyces coelicolor A3(2)
53% identity, 98% coverage
APL_1959 Alcohol dehydrogenase 1 from Actinobacillus pleuropneumoniae L20
APPSER1_RS10665 alcohol dehydrogenase AdhP from Actinobacillus pleuropneumoniae serovar 1 str. 4074
47% identity, 96% coverage
Q9A1X7 Alcohol dehydrogenase from Streptococcus pyogenes serotype M1
SPy0044 putative alcohol dehydrogenase I from Streptococcus pyogenes M1 GAS
48% identity, 98% coverage
- Surface analyses and immune reactivities of major cell wall-associated proteins of group a streptococcus
Cole, Infection and immunity 2005 - “...protein B (fragment) Q9AGC4 46.7 4.60 4 10.8 Housekeeping 15 Q9A1X7 35.4 4.89 6 20.7 Q99YM9 27.0 4.60 19 80.9 Q8K8X1 23.7 4.83 13 79.7 Q9A1E6 25.9 4.49 6...”
- Differential secretomics of Streptococcus pyogenes reveals a novel peroxide regulator (PerR)-regulated extracellular virulence factor mitogen factor 3 (MF3)
Wen, Molecular & cellular proteomics : MCP 2011 - “...in bold). A nonspecific promoter DNA of SPy0044 (150 bp) without a Per box, was amplified using primers: forward, 5-CGGAATTCCAAATATGAAAAAAACTCCCCC-3; reverse,...”
- Point mutations within the streptococcal regulator of virulence (Srv) alter protein-DNA interactions and Srv function
Doern, Microbiology (Reading, England) 2008 - “...( Fig. 3a ) ( Reid et al. , 2004 ). These targets are designated spy0044, spy0285, spy0714 and slr and are located upstream of their corresponding genes spy0044 (zinc-containing dehydrogenase), spy0285 (ATP-binding protein), spy0714 (zinc-binding protein AdcA) and slr (streptococcal leucine-rich protein). In previous work,...”
- “...the migration of spy0285. The EMSA image shown is representative of results obtained with targets spy0044, spy0714 and slr. Fig. 5 EMSA titration of site-directed mutants. Purified rSrv G174S and rSrv S203A binding reactions were conducted with an increasing concentration of protein in order to determine...”
- Inactivation of the group A Streptococcus regulator srv results in chromosome wide reduction of transcript levels, and changes in extracellular levels of Sic and SpeB
Reid, FEMS immunology and medical microbiology 2006 - “...ratio of transcript levels (MGAS5005Dsrv : MGAS5005) for SPy0044, SPy1869, and SPy2019 were 0.598, 0.578, and 0.344, respectively. In the microarray analysis,...”
- “...the fold change for these genes measured 0.64 (SPy0044), 0.70 (SPy1869), and 0.53 (SPy2019). Strong positive correlations between results obtained with the two...”
- Identification of srv, a PrfA-like regulator of group A streptococcus that influences virulence
Reid, Infection and immunity 2004 - “...lipoprotein (43); SPy0285, ATP binding protein (207); SPy0044, zinc-containing dehydrogenase (113); and SPy 0714, zinc binding protein AdcA (28). To test...”
- “...between the transcript levels of the slr, spy2007, spy0285, spy0044, and spy0714 genes may be more pronounced. To investigate if the absence of Srv has an...”
CHF17_RS00445 alcohol dehydrogenase AdhP from Streptococcus agalactiae
SAG0054 alcohol dehydrogenase, propanol-preferring from Streptococcus agalactiae 2603V/R
47% identity, 98% coverage
SAK_0087 alcohol dehydrogenase, zinc-containing from Streptococcus agalactiae A909
47% identity, 98% coverage
- The Role of Regulator Catabolite Control Protein A (CcpA) in Streptococcus agalactiae Physiology and Stress Response
Roux, Microbiology spectrum 2022 - “...differentially regulated by increasing the glucose concentration from 0.25% to 1% in the A909WT strain: SAK_0087 and SAK_1651 coding two alcohol dehydrogenases, SAK_0170 and SAK_0171 belonging to a ribose operon, SAK_0528 and SAK_0529 belonging to a galactitol PTS operon, and SAK_0257 coding a trehalose PTS. In...”
- “...), budB ( SAK_1279 ), pfkA ( SAK_1036 ), ldhA ( SAK_0821 ), adhP ( SAK_0087 ), SAK_0674 , covR ( SAK_1639 ), pflB ( SAK_1735 ), and ahpF ( SAK_1854 ). The major part of the S. agalactiae CcpA regulon is directly regulated through cre...”
- The Adc/Lmb System Mediates Zinc Acquisition in Streptococcus agalactiae and Contributes to Bacterial Growth and Survival
Moulin, Journal of bacteriology 2016 - “...3), in particular, upstream of the adh gene (sak_0087), encoding a potential zinc-containing alcohol dehydrogenase, which has already been identified to be a...”
- “...50 42 32 and 43 52 39 340 38 sak_0087; adh sak_0217; adcR sak_0252 sak_0685; adcA sak_0693 sak_1023 sak_1319; lmb sak_1468 sak_1469 sak_1542 sak_1898; adcAII...”
gbs0054 Unknown from Streptococcus agalactiae NEM316
47% identity, 98% coverage
- The Clinical and Genetic Characteristics of Streptococcus agalactiae Meningitis in Neonates
Hsu, International journal of molecular sciences 2023 - “...the GBS isolates of neonatal meningitis and sepsis using the target genes of alcohol dehydrogenase gbs0054 ( adhP ) as the housekeeping locus and sag 647, sag 1406, and san 1517 for PI-1, PI-2a, and PI-2b, respectively. 3.3. Antimicrobial Susceptibility Testing Antimicrobial susceptibility testing was performed...”
- Genomic epidemiology of Streptococcus agalactiae ST283 in Southeast Asia
Aiewsakun, Scientific reports 2022 - “...sequence type ST283 based on the allelic profiles of seven housekeeping genes, including alcohol dehydrogenase gbs0054 ( adhP ), phenylalanyl tRNA synthetase ( pheS ), amino acid transporter gbs0538 ( atr ), glutamine synthetase ( glnA ), serine dehydratase gbs2105 ( sdhA ), glucose kinase gbs0518...”
- “...Sequence typing assignment Sequence type was determined based on seven housekeeping genes, namely alcohol dehydrogenase gbs0054 ( adhP ), phenylalanyl tRNA synthetase ( pheS ), amino acid transporter gbs0538 ( atr ), glutamine synthetase ( glnA ), serine dehydratase gbs2105 ( sdhA ), glucose kinase gbs0518...”
- Genomic Characterization of Serotype III/ST-17 Group B Streptococcus Strains with Antimicrobial Resistance Using Whole Genome Sequencing
Hsu, Biomedicines 2021 - “...performed to analyze the distribution of GBS PI genes. The target genes, including alcohol dehydrogenase gbs0054 ( adhP ) as housekeeping loci, sag 647 for PI-1, sag 1406 for PI-2a and san 1517 for PI-2b, were used to check in all of the type III GBS...”
- Clinical and Microbiological Characteristics of Group B Streptococcus from Pregnant Women and Diseased Infants in Intrapartum Antibiotic Prophylaxis Era in Taiwan
Lee, Scientific reports 2019 - “...housekeeping genes are used for genotyping GBS using the MLST scheme, including adhP (alcohol dehydrogenase gbs0054), pheS (phenylalanyl transfer RNA synthetase), atr (amino-acid transporter protein gbs0538), glnA (glutamine synthetase), sdhA (L-serine dehydratase gbs2015), glcK (glucose kinase gbs0518), and tkt (transketolase gbs0268). An online database ( http://pubmlst.org/sagalactiae/...”
- Analysis of growth-phase regulated genes in Streptococcus agalactiae by global transcript profiling
Sitkiewicz, BMC microbiology 2009 - “...DNA helicase ruvB TTAAAGCGCTTTCA 69320 69333 92 gbs0053 adh2 Alcohol dehydrogenase TGTAAACGATTACA 72238 72251 100 gbs0054 adhA Alcohol dehydrogenase TGGGAACGGTTTCA 130310 130323 92 gbs0119 ABC transporter permease protein TGTAATCGCTTACT 130334 130347 92 gbs0119 ABC transporter permease protein TATTAACGTTAACA 142634 142647 92 gbs0130 Membrane protease protein family...”
- Multilocus sequence typing system for group B streptococcus
Jones, Journal of clinical microbiology 2003 - “...atr glnA sdhA glcK tkt Alcohol dehydrogenase (gbs0054) Phenylalanyl tRNA synthetase Amino acid transporter (gbs0538) Glutamine synthetase Serine dehydratase...”
- “...538770 287111 a Genes: adhP, alcohol dehydrogenase (gbs0054); pheS, phenylalanyl tRNA synthetase; atr, amino acid transporter (gbs0538); glnA, glutamine...”
SpyM3_0037 putative alcohol dehydrogenase I from Streptococcus pyogenes MGAS315
48% identity, 98% coverage
- Adhesin competence repressor (AdcR) from Streptococcus pyogenes controls adaptive responses to zinc limitation and contributes to virulence
Sanson, Nucleic acids research 2015 - “...37 39 ). Further, the genes encoding alcohol dehydrogenases ( adh ) ( spyM3_0036 and spyM3_0037 ) were significantly upregulated in the adcR strain (Supplementary Table S4). This is contrary to the observations made in pneumococci in which both the genes were downregulated in the adcR...”
- “...). The GAS genome has three genes encoding adh isozymes ( spyM3_0772 , spyM3_0036 and spyM3_0037 ), among which only the spyM3_0772 is annotated as zinc-containing ADH. The adh2 gene ( spyM3_0036 ) encodes a putative iron-containing ADH. Although adh1 is a zinc-dependent ADH, the catalytic...”
G3FFC9 alcohol dehydrogenase (EC 1.1.1.1) from Kluyveromyces marxianus (see paper)
KLMA_40102 alcohol dehydrogenase 1 from Kluyveromyces marxianus DMKU3-1042
44% identity, 98% coverage
- CRISPR-Cas9-enabled genetic disruptions for understanding ethanol and ethyl acetate biosynthesis in Kluyveromyces marxianus
Löbs, Biotechnology for biofuels 2017 - “...ATF genes of interest were identified in the annotated genome of K. marxianus DMKU3-1042 as KLMA_40102, KLMA_40220, KLMA_80306, KLMA_20158, KLMA_20005 KLMA_80339, and KLMA_40624 for Km ADH17, respectively and KLMA_30203 for Km ATF [ 19 ]. Blast searches confirmed the presences of each gene in the unannotated...”
- Genetic basis of the highly efficient yeast Kluyveromyces marxianus: complete genome sequence and transcriptome analyses
Lertwattanasakul, Biotechnology for biofuels 2015 - “...KLMA_20184 Endo-1,3(4)-beta-glucanase 1 DSE4 1,3--D-Glucan KLMA_50517 Endo-1,3(4)-beta-glucanase 2 ACF2 KLMA_10518 Inulinase INU1 Sucrose, raffinose, inulin KLMA_40102 Alcohol dehydrogenase 1 ADH1 KLMA_40220 Alcohol dehydrogenase 2 ADH2 KLMA_80306 Alcohol dehydrogenase 3 ADH3 KLMA_20005 Alcohol dehydrogenase 4a ADH4a KLMA_20158 Alcohol dehydrogenase 4b ADH4b KLMA_40624 Alcohol dehydrogenase ADH KLMA_80339 Alcohol...”
SSA_1917 Alcohol dehydrogenase, propanol-preferring, putative from Streptococcus sanguinis SK36
44% identity, 98% coverage
ADH5 / P38113 alcohol dehydrogenase V (EC 1.1.1.1; EC 1.1.1.190) from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (see 10 papers)
ADH5_YEAST / P38113 Alcohol dehydrogenase 5; Alcohol dehydrogenase V; EC 1.1.1.1 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see 3 papers)
YBR145W Adh5p from Saccharomyces cerevisiae
44% identity, 97% coverage
- function: Can reduces acetaldehyde to ethanol (Probable). The role of ADH5 in yeast metabolism is not yet known, but ADH5 is not responsible for the production of ethanol during growth on glucose nor responsible for the oxidation of ethanol to acetaldehyde (PubMed:22094012).
catalytic activity: a primary alcohol + NAD(+) = an aldehyde + NADH + H(+) (RHEA:10736)
catalytic activity: a secondary alcohol + NAD(+) = a ketone + NADH + H(+) (RHEA:10740)
cofactor: Zn(2+) (Binds 2 Zn(2+) ions per subunit.) - Combinatorial library design for improving isobutanol production in Saccharomyces cerevisiae
Gambacorta, Frontiers in bioengineering and biotechnology 2022 - “...P39522), KDC from S. cerevisiae (Uniprot ID: Q06408), and ADH from S. cerevisiae (Uniprot ID: P38113). A diverse set of variants was chosen from the resulting network by 1) gathering homologs from clusters known to contain active enzyme variants and 2) bioprospecting the network to identify...”
- A model of yeast glycolysis based on a consistent kinetic characterisation of all its enzymes
Smallbone, FEBS letters 2013 - “...Uniprot id Molecules/cell SEM (%) Ref. [36] ADH Adh1p P00330 494000 1.1 0 ADH Adh5p P38113 12800 8.1 1310 ENO Eno1p P00924 2070000 0.9 76700 ENO Eno2p P00925 5950000 0.7 2610 FBA Fba1p P14540 4030000 1020000 GPM Gpm1p P00950 2200000 0.6 172000 HXK Glk1p P17709 136000...”
- Differential requirements for Gcn5 and NuA4 HAT activities in the starvation-induced versus basal transcriptomes
Zheng, Nucleic acids research 2023 - “...and groups: Category Gcn5-Hyp a Data Gcn5/Eaf1-Hyp YBR145W YBR218C YBR248C YBR249C YCL030C YCR005C YDL131W YDL182W YDR127W YDR354W YDR379C-A YDR380W YER052C...”
- “...YOL058W YOR130C YOR230W YOR337W YPL135W YPL250C YPR036W-A YBR145W YBR218C YBR249C YCL030C YCR005C YDL025C YDL131W YDL182W YDL198C YDR127W YDR354W YDR379C-A...”
- Metabolic flux sampling predicts strain-dependent differences related to aroma production among commercial wine yeasts
Scott, Microbial cell factories 2021 - “...L-Alanine:2-oxoglutarate aminotransferase r_4226 Alanine metabolism ACO2 YJL200C Citrate hydroxymutase r_4262 Citric Acid Cycle ADH5 ADH1 YBR145W YOL086C Alcohol dehydrogenase, (acetaldehyde to ethanol) r_2115 Glycolysis, Fatty acid degradation, Tyrosine metabolism, Biosynthesis of secondary metabolites (Ehrlich pathway) GLO2 YDR272W Hydroxyacylglutathione hydrolase r_0553 Pyruvate metabolism GLO1 YML004C Lactoylglutathione lyase...”
- Environmental systems biology of cold-tolerant phenotype in Saccharomyces species adapted to grow at different temperatures
Paget, Molecular ecology 2014 - “...forward rxn: ethanol->acetaldehyde YMR303c ADH2 Pyruvate metabolism 1.1.1.1 Alcohol dehydrogenase: reverse rxn: acetaldehyde->ethanol YOL086c YGL256w YBR145w ADH1 ADH4 ADH5 Pyruvate metabolism 1.1.1.1 Alcohol dehydrogenase: reverse rxn: acetaldehyde->ethanol YMR083w ADH3 Pyruvate metabolism 1.1.1.1 Alcohol dehydrogenase: ethanol YDL168w SFA1 Pyruvate metabolism 1.1.1.1 Adenosine monophosphate deaminase YML035c AMD1 Purine...”
- Origin and consequences of the relationship between protein mean and variance
Vallania, PloS one 2014 - “...in YPEtOH compared to YPD using genome-wide nucleosome occupancy data [33] (YAL054C, YBL015W, YBL075C, YBR139W, YBR145W, YDL097C, YER081W, YFL021W, YGL040C, YGL197W, YLR042C, YMR315W, YNL241C, YOL143C, YOR084W, YPR127W). We constructed a second set (control set) of 15 genes either stable nucleosome-bound or nucleosome-free promoters (YBR066C, YBR092C, YER056C-A,...”
- Metabolic analyses elucidate non-trivial gene targets for amplifying dihydroartemisinic acid production in yeast
Misra, Frontiers in microbiology 2013 - “...(transketolase in PPP) Gene knockdown in strain Fy DHA necessary to emulate this ExPa 1. YBR145W, YGL256W, YOL086C (alcohol dehydrogenase) 1. YBR145W, YGL256W, YOL086C (alcohol dehydrogenase) 2. YBR196C (glucose-6-phosphate isomerase) The characteristics of two key ExPas with reasonable DHA and biomass yields are shown, with the...”
- Adjustment of trehalose metabolism in wine Saccharomyces cerevisiae strains to modify ethanol yields
Rossouw, Applied and environmental microbiology 2013 - “...ALD4/ALD3 ALD5/ALD2/ALD3 ALD7 YOL086c YMR303c YMR083w YGL256w YBR145w YPL061w YMR169c YMR170c YOR374w Y16236 Y10891 Y16217 Y14623 Y13284 Y12767 Y10752 Y10753...”
- Ontology-Based Querying with Bio2RDF's Linked Open Data
Callahan, Journal of biomedical semantics 2013 - “...identifier Gene label Description Protein identifier http://bio2rdf.org/sgd:S000004688 YMR083W Mitochondrial alcohol dehydrogenase isozyme III http://bio2rdf.org/sgd:S000004688gp http://bio2rdf.org/sgd:S000000349 YBR145W Alcohol dehydrogenase isoenzyme V http://bio2rdf.org/sgd:S000000349gp http://bio2rdf.org/sgd:S000002624 YDR216W Carbon source-responsive zinc-finger transcription factor http://bio2rdf.org/sgd:S000002624gp http://bio2rdf.org/sgd:S000000819 YER017C Component of the mitochondrial inner membrane m-AAA protease http://bio2rdf.org/sgd:S000000819gp http://bio2rdf.org/sgd:S000001306 YIL044C ADP-ribosylation factor (ARF) GTPase...”
- Integration of general amino acid control and target of rapamycin (TOR) regulatory pathways in nitrogen assimilation in yeast
Staschke, The Journal of biological chemistry 2010 - “...YIL164C YHR029C YGR087C YER175C YER065C YDL032W YCL027W YBR147W YBR145W YPL033C YPL092W YOL058W YNR068C YNR069C SRY1 Description on GCN4 (Fig. 2A and Table 2)....”
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CTRG_05482, XP_002551184 alcohol dehydrogenase 2 from Candida tropicalis MYA-3404
43% identity, 98% coverage
- Characteristics of Extracellular Vesicles Released by the Pathogenic Yeast-Like Fungi Candida glabrata, Candida parapsilosis and Candida tropicalis
Karkowska-Kuleta, Cells 2020 - “...CTRG_05018 (Cyp1) + gi|255732093 (XP_002550970) ADP,ATP carrier protein CTRG_05268 + gi|255732521 (XP_002551184) alcohol dehydrogenase 2 CTRG_05482 (Adh2) + + + gi|255732780 (XP_002551313) putative plasma membrane protein CTRG_05611 + + gi|255732890 (XP_002551368) glyceraldehyde-3-phosphate dehydrogenase CTRG_05666 (Tdh3) + gi|255732910 (XP_002551378) predicted protein CTRG_05676 + gi|255733002 (XP_002551424) plasma membrane...”
- “...(XP_002550720) peptidyl-prolyl cis-trans isomerase CTRG_05018 (Cyp1) + gi|255732093 (XP_002550970) ADP,ATP carrier protein CTRG_05268 + gi|255732521 (XP_002551184) alcohol dehydrogenase 2 CTRG_05482 (Adh2) + + + gi|255732780 (XP_002551313) putative plasma membrane protein CTRG_05611 + + gi|255732890 (XP_002551368) glyceraldehyde-3-phosphate dehydrogenase CTRG_05666 (Tdh3) + gi|255732910 (XP_002551378) predicted protein CTRG_05676 +...”
- Cellular Analysis and Comparative Transcriptomics Reveal the Tolerance Mechanisms of Candida tropicalis Toward Phenol
Wang, Frontiers in microbiology 2020 - “...in the conversion of fatty acid to alcohol ( Figure 7 ). Specifically, CTRG_05836, CTRG_00882, CTRG_05482, CTRG_01329, and CTRG_05010 were significantly down-regulated in response to 2.0 g/L phenol exposure ( Figure 7 ). These results suggested that decreased fatty acid degradation efficiency, caused by the down-regulation...”
Spaf_0170 alcohol dehydrogenase AdhP from Streptococcus parasanguinis FW213
45% identity, 98% coverage
SM12261_RS01275 alcohol dehydrogenase AdhP from Streptococcus mitis NCTC 12261
44% identity, 98% coverage
SSU05_0279 alcohol dehydrogenase from Streptococcus suis 05ZYH33
SSU98_0274 alcohol dehydrogenase from Streptococcus suis 98HAH33
SSUSC84_0249 alcohol dehydrogenase from Streptococcus suis SC84
SSU0260 alcohol dehydrogenase from Streptococcus suis P1/7
44% identity, 98% coverage
- The Redox-Sensing Regulator Rex Contributes to the Virulence and Oxidative Stress Response of Streptococcus suis Serotype 2
Zhu, Frontiers in cellular and infection microbiology 2018 - “...1.79 2.55 0.15 Shift SSU05_2153 A0A0H3MXX6 frdA Fumarate reductase flavoprotein subunit 7.59 6.10 0.34 Shift SSU05_0279 A4VT08 adhP Zn-dependent alcohol dehydrogenase 16.29 44.84 2.2 NT BM407_0341 A0A0Z8EN96 clpL ATP-dependent protease ATP-binding subunit ClpL 2.29 1.32 0.12 No shift a NT indicates that a gene was not...”
- The Eukaryote-Like Serine/Threonine Kinase STK Regulates the Growth and Metabolism of Zoonotic Streptococcus suis
Zhang, Frontiers in cellular and infection microbiology 2017 - “...genes in the glycolysis were significantly down-regulated, including ptsG (SSU05_0397), crr (SSU05_0398), pgk (SSU05_0157), adhA (SSU05_0279), and adhE (SSU05_0280) (Figure 4 ). Notably, expression levels of rpsN (SSU05_1535), rpsR (SSU05_1832), rpsP (SSU05_0796), rpsU (SSU05_1433), and glyS (SSU05_1764) translation-associated genes in the pathways of ribosome and aminoacyl-tRNA...”
- The roles of RelA/(p)ppGpp in glucose-starvation induced adaptive response in the zoonotic Streptococcus suis
Zhang, Scientific reports 2016 - “...glucose starvation. The genes encoding enzymes associated with alcohol utilization were also up-regulated, including adhA (SSU05_0279) and adhE (SSU05_0280). The arcABC operon (SSU05_0624, SSU05_0626, SSU05_0627) encoding the arginine deiminase system (ADS) was significantly up-regulated in both SC-19 and relA , and the fold change of this...”
- In vitro transcriptome analysis of two Chinese isolates of Streptococcus suis serotype 2
Zhang, Genomics, proteomics & bioinformatics 2014 - “...05ZYH33 2.7.1.69 SSU05_0398 1.56 PTS IIC component, glucose/maltose/ N -acetylglucosamine-specific 3.2.1.86 SSU05_2079 1.69 Alpha-galactosidase/6-phospho-beta-glucosidase 1.1.1.1 SSU05_0279 2.29 Alcohol dehydrogenase 1.1.1.1 SSU05_0280 3.01 Bifunctional acetaldehyde-CoA/alcohol dehydrogenase 3.2.1.86 SSU05_1489 5.05 Beta-glucosidase/6-phospho-beta-glucosidase/beta-galactosidase Note: FC stands for fold change, which was calculated by log 2 expression of the respective Chinese...”
- Effect of licochalcone A on growth and properties of Streptococcus suis
Hao, PloS one 2013 - “...SSU05_0076 AGCAGACGCAATCGCAATC GCTTCGCTGACTACCAAGTTAG SSU05_0083 GGCTTCCGTCTTCGTGAG AAGTGAAACTGTAACCAATTTGTC SSU05_0085 TTGCCTGCTGGTGTTGAG GTTTGGACGGTGAAGAGTTAC SSU05_0087 ACAATCCCTCACGAAGTTC AAGTCACATCTGCGATACC SSU05_0089 GTGGTACATCATCAGGTAACG GGAAGACGACGGAACAATG SSU05_0279 GCTACTCTGTTGACGGTGGTATG AGTAACGCCAGCACAAGTGATAG SSU05_0280 TGTCACCTGTTATTGCCGTCTTG TTCTGCGTCTTCCGTATGAATAGC SSU05_0479 AGTGCTGGCGTCAAAGATGG TGAAGAAGGTTGGCAGGTAATCC SSU05_1759 ACTATACGAAGGCTGAACCAATC CTACGAGCATAGAGCACTAAGG References 1 Gottschalk M , Segura M , Xu J ( 2007 ) Streptococcus suis infections in humans: the...”
- In vitro transcriptome analysis of two Chinese isolates of Streptococcus suis serotype 2
Zhang, Genomics, proteomics & bioinformatics 2014 - “...Glycolysis/gluconeogenesis pathway 98HAH33 2.7.1.69 SSU98_0384 1.92 PTS IIC component, glucose 3.2.1.86 SSU98_2083 1.02 Alpha-galactosidase 1.1.1.1 SSU98_0274 1.63 AdhA 1.1.1.1 SSU98_0275 1.92 Bifunctional acetaldehyde-CoA 3.2.1.86 SSU98_1500 6.14 Beta-glucosidase 05ZYH33 2.7.1.69 SSU05_0398 1.56 PTS IIC component, glucose/maltose/ N -acetylglucosamine-specific 3.2.1.86 SSU05_2079 1.69 Alpha-galactosidase/6-phospho-beta-glucosidase 1.1.1.1 SSU05_0279 2.29 Alcohol dehydrogenase...”
- Exogenous glycogen utilization effects the transcriptome and pathogenicity of Streptococcus suis serotype 2
Tan, Frontiers in cellular and infection microbiology 2022 - “...ATP-dependent zinc metalloprotease -3.45 -4.76 1.03 SSUSC84_0092 rpmJ 50S ribosomal protein L36 -7.14 -12.50 1.40 SSUSC84_0249 adhP Alcohol dehydrogenase 76.28 61.15 3.51 SSUSC84_0270 dnaJ Molecular chaperone 7.58 2.84 0.65 SSUSC84_0376 cysK Cysteine synthase A -6.25 -5.88 1.12 SSUSC84_0671 mrp MucBP domain-containing protein -9.09 -25.06 1.01 SSUSC84_0917...”
- Comparative transcriptomic analysis reveal genes involved in the pathogenicity increase of Streptococcus suis epidemic strains
Wang, Virulence 2022 - “...Lipoprotein G 4h SSUSC84_0145 SSU0152 MUN40_01300 Sspep d O SSUSC84_0242 SSU0253 - HP272 d D SSUSC84_0249 SSU0260 MUN40_01895 Alcohol dehydrogenase C SSUSC84_0440 SSU0456 MUN40_08175 Membrane protein S SSUSC84_0566 SSU0593 MUN40_05180 Hypothetical protein C2 S SSUSC84_0567 SSU0594 MUN40_05175 Hypothetical protein S SSUSC84_0568 SSU0595 MUN40_05170 Hypothetical protein S...”
- Comparative transcriptomic analysis reveal genes involved in the pathogenicity increase of Streptococcus suis epidemic strains
Wang, Virulence 2022 - “...G 4h SSUSC84_0145 SSU0152 MUN40_01300 Sspep d O SSUSC84_0242 SSU0253 - HP272 d D SSUSC84_0249 SSU0260 MUN40_01895 Alcohol dehydrogenase C SSUSC84_0440 SSU0456 MUN40_08175 Membrane protein S SSUSC84_0566 SSU0593 MUN40_05180 Hypothetical protein C2 S SSUSC84_0567 SSU0594 MUN40_05175 Hypothetical protein S SSUSC84_0568 SSU0595 MUN40_05170 Hypothetical protein S SSUSC84_0773...”
NMA0725 putative alcohol dehydrogenase from Neisseria meningitidis Z2491
48% identity, 90% coverage
P20369 Alcohol dehydrogenase 1 from Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
43% identity, 97% coverage
MUN40_01895 alcohol dehydrogenase AdhP from Streptococcus suis 89-1591
44% identity, 98% coverage
ADH2 / GB|CAA21988.1 alcohol dehydrogenase 2; EC 1.1.1.1 from Candida albicans (see paper)
43% identity, 98% coverage
- CharProtDB CGD description: Putative alcohol dehydrogenase; soluble protein in hyphae; fungal-specific (no human or murine homolog); expression is regulated upon white-opaque switching; regulated by Ssn6p; transcriptionally activated by Mnl1p under weak acid stress
Q5F6V3 alcohol dehydrogenase from Neisseria gonorrhoeae (strain ATCC 700825 / FA 1090)
NGO1442 alcohol dehydrogenase from Neisseria gonorrhoeae FA 1090
47% identity, 97% coverage
- Comparative Proteomics of Extended-Spectrum Cephalosporin-Resistant Neisseria gonorrhoeae Isolates Demonstrates Altered Protein Synthesis, Metabolism, Substance Transport, and Membrane Permeability
Diao, Frontiers in microbiology 2020 - “...Q5F6C9 NGO_1630 Repressor X 0 N 6.95 Q5F6D2 NGO_1627 Uncharacterized protein K 0 N 5.49 Q5F6V3 adhP Ethanolactive dehydrogenase/acetaldehydeactive reductase G 0 N 4.18 Q5F873 gltA Citrate synthase C 0 N 2.13 Q5F8G6 ilvD Dihydroxyacid dehydratase EG 0 N 1.73 Q5F9V2 NGO_0286 Uncharacterized protein S 0...”
- “...a D6H9Y3 asd Aspartate-semialdehyde dehydrogenase 2.31 4.35 a D6HBH4 NGMG_02139 3-hydroxyacid dehydrogenase 3.35 1.84 a Q5F6V3 adhP Ethanol-active dehydrogenase/acetaldehyde-active reductase 4.18 2.31 a Q5F873 gltA Citrate synthase 2.13 1.98 a Q5F8G6 ilvD Dihydroxy-acid dehydratase 1.73 3.07 a A0A0M3GY07 tsf Elongation factor Ts, EF-Ts 3.75 2.39 a...”
- Dual species transcriptomics reveals conserved metabolic and immunologic processes in interactions between human neutrophils and Neisseria gonorrhoeae
Potter, PLoS pathogens 2024 - “...response proteins (NGO1189- hslO , NGO1249- ahpD , NGO1328- cycB , NGO1371- ccoP , and NGO1442- adhA ), stress response and protein folding (NGO0116- secB , NGO0630- hscB , NGO0829- hscA , NGO1046- clpB , NGO1422- grpE ), transcription and translation proteins (NGO0191- rpsO , NGO0295-...”
- Identification of the iron-responsive genes of Neisseria gonorrhoeae by microarray analysis in defined medium
Ducey, Journal of bacteriology 2005 - “...NMB0460 NMB0461 NMB0634 NGO0322 NGO0385 NGO0165c NGO1442 NGO0108 NGO1066 NGO0025 NGO2093c Conserved hypothetical protein Delta-aminolevulinic acid dehydratase...”
ADH2 / P00331 alcohol dehydrogenase II (EC 1.1.1.1; EC 1.1.1.190) from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (see 10 papers)
ADH2_YEAST / P00331 Alcohol dehydrogenase 2; Alcohol dehydrogenase II; ADHII; YADH-2; EC 1.1.1.1 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see 6 papers)
NP_014032 alcohol dehydrogenase ADH2 from Saccharomyces cerevisiae S288C
YMR303C Adh2p from Saccharomyces cerevisiae
43% identity, 98% coverage
- function: Preferentially oxidative, glucose-repressed isozyme that catalyzes the conversion of ethanol to acetaldehyde. Main enzyme involved in ethanol consumption. Acts on a variety of primary unbranched aliphatic alcohols (Probable) (PubMed:3546317). Also produces ethanol from glucose, albeit less than ADH1 (PubMed:22094012).
catalytic activity: a primary alcohol + NAD(+) = an aldehyde + NADH + H(+) (RHEA:10736)
catalytic activity: a secondary alcohol + NAD(+) = a ketone + NADH + H(+) (RHEA:10740)
catalytic activity: ethanol + NAD(+) = acetaldehyde + NADH + H(+) (RHEA:25290)
catalytic activity: butan-1-ol + NAD(+) = butanal + NADH + H(+) (RHEA:33199)
catalytic activity: hexan-1-ol + NAD(+) = hexanal + NADH + H(+) (RHEA:60972)
cofactor: Zn(2+) (Binds 2 Zn(2+) ions per subunit.)
subunit: Homotetramer - Light-driven biocatalytic oxidation
Yun, Chemical science 2022 - “...concentrated by ultra-filtration 23 Dehydrogenase Alcohol dehydrogenase (ADH) from Saccharomyces cerevisiae ( Sc ADH) AAA34411 (P00331) Sc ADH gene was transformed into S. cerevisiae 30221#2 strain that does not produce active alcohol dehydrogenase, and cultivated in YEPD medium and antimycin A (1 g mL 1 )...”
- Regulation of xylose metabolism in recombinant Saccharomyces cerevisiae
Salusjärvi, Microbial cell factories 2008 - “...0.2 0.3 -1.2 -0.6 P00330 Adh1p_b YOL086C alcohol dehydrogenase 2.1 0.9 0.5 0.3 -1.6 -0.6 P00331 Adh2p YMR303C alcohol dehydrogenase 4.8 -2.6 5.7 1.4 0.9 4.0 P47143 Ado1p_a YJR105W adenosine kinase -1.1 0.4 -1.4 -1.3 -0.2 -1.7 P47143 Ado1p_b YJR105W adenosine kinase -1.4 0.4 -1.9 -1.3...”
- Purification and properties of methyl formate synthase, a mitochondrial alcohol dehydrogenase, participating in formaldehyde oxidation in methylotrophic yeasts
Murdanoto, Applied and environmental microbiology 1997 - “...(cytosolic), P00330; S. cerevisiae Adh2p (cytosolic), P00331; S. cerevisiae Adh3p (mitochondrial), P07246; Kluyveromyces lactis Adh1p (cytosolic), P20369; K....”
- [Cloning, expression and evaluation of Saccharomyces cerevisiae ADH2].
Yu, Sheng wu gong cheng xue bao = Chinese journal of biotechnology 2010 (PubMed)- GeneRIF: ADH2 proved to have ethanol dehydrogenase activity.
- Snf1-independent, glucose-resistant transcription of Adr1-dependent genes in a mediator mutant of Saccharomyces cerevisiae.
Young, Molecular microbiology 2009 (PubMed)- GeneRIF: ADH2 expression in the med14 mutant is stimulated by Adr1.
- Artificial recruitment of mediator by the DNA-binding domain of Adr1 overcomes glucose repression of ADH2 expression.
Young, Molecular and cellular biology 2008 - GeneRIF: ADH2 expression was dependent on these factors with wild-type Adr1
- Snf1-dependent and Snf1-independent pathways of constitutive ADH2 expression in Saccharomyces cerevisiae.
Voronkova, Genetics 2006 - GeneRIF: analysis of Snf1-dependent and Snf1-independent pathways of constitutive ADH2 expression in Saccharomyces cerevisiae
- The ISWI and CHD1 chromatin remodelling activities influence ADH2 expression and chromatin organization.
Xella, Molecular microbiology 2006 (PubMed)- GeneRIF: the absence of the Isw1 and Chd1 ATP-dependent chromatin remodelling activities delays the maximal expression of ADH2 without impairing the chromatin remodelling that occurs upon activation
- Metabolic regulation of misfolded protein import into mitochondria
Wang, eLife 2024 - “...ENO1 Class 2 YMR257C PET111 Class 2 YMR278W PRM15 Class 2 YMR291W TDA1 Class 2 YMR303C ADH2 Class 2 YNL303W Class 2 YNL302C RPS19B Class 2 YNL265C IST1 Class 2 YNL264C PDR17 Class 2 KEGG pathway analysis revealed that genes corresponding to the hits validated with...”
- Metabolic flux sampling predicts strain-dependent differences related to aroma production among commercial wine yeasts
Scott, Microbial cell factories 2021 - “...YGR087C YLR044C YLR134W Pyruvate decarboxylase r_0959 Glycolysis, Gluconeogenesis, Biosynthesis of secondary metabolites (Ehrlich pathway) ADH2 YMR303C Alcohol dehydrogenase (ethanol to acetaldehyde) r_0163 Glycolysis, Tyrosine metabolism, Biosynthesis of secondary metabolites (Ehrlich pathway), Fatty acid degradation GLK1 HXK1 HXK2 EMI2 YLR446W YCL040W YFR053C YGL253W YDR516C Hexokinase (D-glucose:ATP) r_0534...”
- Aspirin impairs acetyl-coenzyme A metabolism in redox-compromised yeast cells
Farrugia, Scientific reports 2019 - “...Encoded Protein Fold Change EG110+ASA vs EG110 EG103+ASA vs EG103 EG110 vs EG103 # 1774070_at YMR303C ADH2 Ethanol-induced alcohol dehydrogenase isoform 2 3.01*** 1.06 NS 1.40** 1772915_at YAL054C ACS1 Acetyl-CoA synthetase isoform 1 (repressed by glucose) 2.72*** 1.01 NS 1.08 NS 1774377_at YML042W CAT2 Carnitine acetyltransferase...”
- Transcriptional Comparison Investigating the Influence of the Addition of Unsaturated Fatty Acids on Aroma Compounds During Alcoholic Fermentation
Yan, Frontiers in microbiology 2019 - “...regulator 0.46 YML120C NDI1 NADH: ubiquinone oxidoreductase 0.39 YDL085W NDE2 Mitochondrial external NADH dehydrogenase 0.41 YMR303C ADH2 Glucose-repressible alcohol dehydrogenase II 0.38 YLR393W ATP10 Assembly factor for the F0 sector of mitochondrial F1F0 ATP synthase 0.45 YLL018C-A COX19 Protein required for cytochrome c oxidase assembly 0.42...”
- Modular 5'-UTR hexamers for context-independent tuning of protein expression in eukaryotes
Petersen, Nucleic acids research 2018 - “...transformation of the alcohol dehydrogenase II (ADH2) promoter fragment (700 bp upstream position +1 of YMR303C), and one of eight TIS-yeGFP into strain TC-3 ( 43 ) for recombination at the XII-5 site. Homology between fragments was 30 bp, with up and down fragments of at...”
- Biotransformation, Using Recombinant CYP450-Expressing Baker's Yeast Cells, Identifies a Novel CYP2D6.10A122V Variant Which Is a Superior Metabolizer of Codeine to Morphine Than the Wild-Type Enzyme
Williams, ACS omega 2018 - “...driving expression of human CYP genes in yeast, the ADH2 promoter (ADH2p; Saccharomyces Genome Database; YMR303C) was used. The ADH2p is repressed in glucose-containing medium and is induced by ethanol. The ADH2 promoter is gradually induced through steady conversion of glucose, present in the yeast cell...”
- Metschnikowia pulcherrima Influences the Expression of Genes Involved in PDH Bypass and Glyceropyruvic Fermentation in Saccharomyces cerevisiae
Sadoudi, Frontiers in microbiology 2017 - “...GCTGTTCGGCTTCGTTAGA 19 ADH1 (YOL086C) 854068 Alcohol dehydrogenase, isozyme 1 GGTCACTGGGTTGCTATCTCC 21 107 CCTTCACCACCGTCAATACC 20 ADH2 (YMR303C) 855349 Alcohol dehydrogenase, isozyme 2 TGCCCACGGTATCATCAAT 19 98 GCAAACCAACCAAGACAACAG 21 CAT2 (YML042W) 854965 Carnitine acetyltransferase 2 CAAACTGATGACCCATGACG 20 94 GGACTGCGATCCTTGGAATA 20 GPD1 (YDL022W) 851539 Glycerol-3-phosphate dehydrogenase isozyme 1 TTTTGCCCCGTATCTGTAGC 20...”
- Generation of infectious recombinant Adeno-associated virus in Saccharomyces cerevisiae
Barajas, PloS one 2017 - “...and Pac I, resulting in plasmid DB155-pESC(H)-VP3-AAP(op)-TEF1p-FKBP46-HA. The upstream region of S . cerevisiae ADH2 (YMR303C) containing the ADH2 promoter (ADH2p) was amplified by PCR with primers DB149 and DB150. A DNA fragment from pESC-TRP1 containing the TRP1 polyadenylation signal was amplified by PCR with primers...”
- More
NMB0546 alcohol dehydrogenase from Neisseria meningitidis MC58
48% identity, 90% coverage
- The Hfq regulon of Neisseria meningitidis
Huis, FEBS open bio 2017 - “...& Propionate metabolism 5.9 3.9 NMB0435 ackA1 Acetate kinase Propionate metabolism 14.9 2.0 13.7 18.1 NMB0546 adhP Alcohol dehydrogenase Oxidoreductases 1.5 1.7 NMB0574 gcvT Aminomethyltransferase Amino acid metabolism 3.1 2.6 NMB0589 rplS 50S ribosomal protein L19 Ribosomal proteins 3.7 7.3 NMB0634 fpbA Iron ABC transporter Membrane...”
- “...uptake regulator (Zur) that represses proteins involved in zinc uptake such as ZnuD 79 . NMB0546 (the zinccontaining alcohol dehydrogenase AdhP) is known to be downregulated under conditions of zinc limitation, while NMB0317 (NADPHdependent 7cyano7deazaguanine reductase QueF, involved in queuosine biosynthesis) is downregulated when zinc is...”
- Neisseria meningitidis Lacking the Major Porins PorA and PorB Is Viable and Modulates Apoptosis and the Oxidative Burst of Neutrophils
Peak, Journal of proteome research 2016 - “...mutant strain, as well as reductions of PpsA (phosphoenolpyruvate synthase, NMB0618), AdhP (alcohol dehydrogenase, propanol-preferring, NMB0546), and AcnB (aconitate hydratase, NMB1572.) Cellular processes associated with proline also appear to be affected, with downregulation of ProS (NMB0133) and PutA (NMB0401) in the double mutant, strain 58AB. As...”
- Transcriptional profiling of Neisseria meningitidis interacting with human epithelial cells in a long-term in vitro colonization model
Hey, Infection and immunity 2013 - “...h 21 days NMB0018 NMB0128 NMB0143 NMB0345 NMB0382 NMB0546 NMB0554 NMB0604 NMB0634 NMB1313 NMB1429 NMB1533 NMB1710 NMB1972 NMB2039 NMB2159 pilE rplA rplD 1.8 2.2...”
- The zinc-responsive regulon of Neisseria meningitidis comprises 17 genes under control of a Zur element
Pawlik, Journal of bacteriology 2012 - “...MP183 MP19 MP184 475 469 qRT-PCR nmb0317 nmb0525 nmb0546 nmb0577 nmb0586 nmb0587 nmb0588 nmb0817 nmb0819 nmb0820 nmb0942 nmb0964 nmb0990 nmb1475 nmb1497 nmb2142...”
- “...71 80 81 68 68 68 EMSA nmb0546 MP191 CTTTCCAAGATGTTATAATATAACA TATAATCTAT MP192 AAATATAGATTATATGTTATAT TATAACATCTTGG 35 nmb0964 Unaltered MP185 MP186 MP193 CA...”
- Role of Hfq in iron-dependent and -independent gene regulation in Neisseria meningitidis
Mellin, Microbiology (Reading, England) 2010 - “...pprC Methylcitrate synthase 23.87 19.69 1.19 1.82 NMB0435 ackA-1 Acetate kinase 13.65 10.26 1.75 2.43 NMB0546 adhP Alcohol dehydrogenase 1.71 3.09 1.15 1.09 NMB1572 acnB Aconitate hydratase 2.71 2.97 1.11 1.19 Transport: NMB0177 Sodium/alanine symporter 13.07 10.65 1.14 1.14 NMB0402 putp Sodium/proline symporter 2.94 1.58 1.27...”
- Comparative genome biology of a serogroup B carriage and disease strain supports a polygenic nature of meningococcal virulence
Joseph, Journal of bacteriology 2010 - “...CP lbpA lbpB acnB aroB Poorly characterized NMB0330 NMB0546 NMB0902 NMB0906 NMB0995 NMB1048 NMB1494 NMB1753 NMB1906 Not in COGs NMB0374 NMB0460 NMB0467 NMB0483...”
- Molecular characterization and identification of proteins regulated by Hfq in Neisseria meningitidis
Pannekoek, FEMS microbiology letters 2009 - “...714 5.0352 4a NMB0431 PrpC C + Methylcitrate synthase Carbohydrate metabolism 42 818 7.1147 NS NMB0546 AdhP W + Alcohol dehydrogenase (propanol preferring) Fermentation 36 547 5.8432 4b NMB0554 DnaK W + Molecular chaperone Environmental information processing 68 791 4.5862 4a NMB0589 RplS CE + 50S...”
- Modeling Neisseria meningitidis metabolism: from genome to metabolic fluxes
Baart, Genome biology 2007 - “...in Additional data file 1. Ethanol is synthesized from acetaldehyde using alcohol dehydrogenase, EC 1.1.1.1 (NMB0546). Remarkably, no gene(s) involved in the biosynthesis of acetaldehyde are found in the MenB genome. Because ethanol was measured in the culture supernatant, a biosynthetic pathway to ethanol must be...”
- More
spr0262 Alcohol dehydrogenase, propanol-preferring. from Streptococcus pneumoniae R6
SP_0285 alcohol dehydrogenase from Streptococcus pneumoniae TIGR4
SPD_0265 alcohol dehydrogenase, zinc-containing from Streptococcus pneumoniae D39
SPD_RS01445, SP_RS01400 alcohol dehydrogenase AdhP from Streptococcus pneumoniae TIGR4
44% identity, 98% coverage
- Penicillin induces alterations in glutamine metabolism in Streptococcus pneumoniae
El, Scientific reports 2017 - “...MreC 1.19 spr2024 ABC-MSP ABC transporter permease 1.07 Upregulated spr0096 LysM domain-containing protein 1.46 1.84 spr0262 adhP alcohol dehydrogenase 1.17 spr0287 kdgA keto-hydroxyglutarate-aldolase/keto-deoxy-phosphogluconate aldolase 1.00 1.00 1.58 spr0289 hypothetical protein 1.00 1.00 1.58 spr0307 clpL ATP-dependent protease ATP-binding subunit 2.16 spr0311 hypothetical protein 1.32 2.04 spr0342...”
- Comparative transcriptomic analysis of streptococcus pseudopneumoniae with viridans group streptococci
Park, BMC microbiology 2012 - “...- spr0535 ABC transporter ATP-binding protein 6 3 6 spr0853 Alanine dehydrogenase 2 - - spr0262 alcohol dehydrogenase - 1 - spr0247 Alkaline amylopullulanase - 1 - spr0307 ATP-dependent protease 1 - - spr1862 Competence protein 1 - - spr0469 Conserved hypothetical protein - - 4...”
- Targeting NAD+ regeneration enhances antibiotic susceptibility of Streptococcus pneumoniae during invasive disease
Im, PLoS biology 2023 - “...in general had negative consequence. A recent study by our group has shown that adh (SP_0285, zinc-containing alcohol dehydrogenase) is highly expressed in the airway and organs of mice during invasive pneumococcal disease [ 24 , 39 ]. Other investigators have reported that adh is a...”
- “...work agrees with and builds on prior work that alcohol dehydrogenases are vital enzymes. Adh (SP_0285) and AdhE (SP_2026) share near identical binding sites for their substrates [ 42 , 43 ]. It is noteworthy that in follow-up experiments, a double knockout of adh/adhE behaved similarly...”
- Anatomical Site-Specific Carbohydrate Availability Impacts Streptococcus pneumoniae Virulence and Fitness during Colonization and Disease
Im, Infection and immunity 2022 (secret) - Biofilm and planktonic pneumococci demonstrate disparate immunoreactivity to human convalescent sera
Sanchez, BMC microbiology 2011 - “...Gene Product Annotation* elongation factor G ( fusA ) SP_0273* alcohol dehydrogenase ( adhP ) SP_0285 trigger factor ( tig ) SP_0400 3-oxoacyl-(acyl carrier protein) synthase II SP_0422 phosphoglycerate kinase ( pgk ) SP_0499 molecular chaperone DnaK ( dnaK ) SP_0517* phenylalanyl-tRNA synthetase subunit beta (...”
- Deletion of the Zinc Transporter Lipoprotein AdcAII Causes Hyperencapsulation of Streptococcus pneumoniae Associated with Distinct Alleles of the Type I Restriction-Modification System
Durmort, mBio 2020 - “...transporter permease 2.28 2.11 1.46 SPD_0226 pitA PitA iron ABC transporter lipoprotein 2.01 1.37 1.72 SPD_0265 adhP Alcohol dehydrogenase 1.80 1.83 1.63 SPD_0279 celB Cellobiose PTS system IIB component 2.28 1.79 1.76 SPD_0300 Oligohyaluronate lyase 2.49 1.60 1.32 SPD_0362 mtlF Mannitol PTS system IIA component 2.38...”
- Redefining the Small Regulatory RNA Transcriptome in Streptococcus pneumoniae Serotype 2 Strain D39
Sinha, Journal of bacteriology 2019 - “...ruvB ruvB, spd_0240 spd_0242, uppS spd_0266, spd_0265 spd_0288, spd_0287 spd_0371, spd_0372 Spd_sr29 381067-381205 () spd_0376, serS Spd_sr31b Spd_sr32b...”
- Autoinducer 2 Signaling via the Phosphotransferase FruA Drives Galactose Utilization by Streptococcus pneumoniae, Resulting in Hypervirulence
Trappetti, mBio 2017 - “...Hypothetical protein 3.9 SPD_0115 Hypothetical protein 3.9 SPD_0116 Hypothetical protein 4.5 SPD_0117 Hypothetical protein 0.4 SPD_0265 adhA Alcohol dehydrogenase 0.7 SPD_0309 luxS LuxS S -ribosylhomocysteine lyase 0.0003 SPD_0334 aliA Oligopeptide-binding protein AliA 2.1 SPD_0404 ilvB Lactose phosphotransferase system repressor 1.7 SPD_0405 ilvN Acetolactate synthase 1.7 SPD_0406...”
- Integrated Translatomics with Proteomics to Identify Novel Iron-Transporting Proteins in Streptococcus pneumoniae
Yang, Frontiers in microbiology 2016 - “...0.043 40.12 0.000 111 gi|116515457 SPD_0249 Hypothetical protein SPD_0249 0.72 0.003 0.27 0.000 118 gi|116516519 SPD_0265 Alcohol dehydrogenase 8.22 0.002 58.39 0.000 127 gi|116516839 SPD_0292 Gluconate 5-dehydrogenase 3.57 0.026 98.08 0.000 143 gi|116517149 lctO Lactate oxidase 1.69 0.000 6.04 0.000 304 gi|116515416 SPD_1793 Universal stress protein...”
- Ethanol-induced alcohol dehydrogenase E (AdhE) potentiates pneumolysin in Streptococcus pneumoniae
Luong, Infection and immunity 2015 - “...the S. pneumoniae type 2 D39 strain, including SPD_0265, SPD_1126, SPD_1636, SPD_1834, SPD_1865, and SPD_1985, only SPD_1834 (104-kDa protein), which encodes a...”
- “...substrate (45). Moreover, a BLAST search revealed that SPD_0265 has 93% identity with S. gordonii AdhA, which preferentially catalyzes 1-propanol (45). SPD_1126...”
- Lactate dehydrogenase is the key enzyme for pneumococcal pyruvate metabolism and pneumococcal survival in blood
Gaspar, Infection and immunity 2014 - “...additional genes annotated as alcohol dehydrogenase; these are SPD_0265, SPD_1126, and SPD_1865. Of these, SPD_1126 expression in the mutant did not change...”
- “...relative to the wild type in all tissues, while SPD_0265 and SPD_1865 expression increased in nasopharynx (P 0.05), which may imply that their activity also...”
- The metalloregulatory zinc site in Streptococcus pneumoniae AdcR, a zinc-activated MarR family repressor
Reyes-Caballero, Journal of molecular biology 2010 - “...the adcR strain. Interestingly, two putative zinc-containing alcohol dehydrogenases are down-regulated in the adcR strain, SPD_0265 and SPD_1865 ( Fig. 1 ). Although it is unknown if this is a direct or indirect effect of the deletion, the intergenic region upstream of the promoter for SPD_1865...”
- SPD_0410 negatively regulates capsule polysaccharide synthesis and virulence in <i>Streptococcus pneumoniae</i> D39
Tao, Frontiers in microbiology 2024 - “...1.23677 0.000476 Glucose metabolism SPD_RS00330 bgaC beta-galactosidase 1.16233 0.000450 SPD_RS00360 galM Galactose mutarotase 1.56759 0.000132 SPD_RS01445 adhP Alcohol dehydrogenase AdhP 1.04334 0.005366 SPD_RS02705 bglA-2 Glycoside hydrolase family 1 protein 1.38018 4.89E-08 SPD_RS05615 lacG 6-phospho-beta-galactosidase 1.05771 0.001894 SPD_RS10415 spd_1968 Beta-N-acetylhexosaminidase 1.18103 0.003663 SPD_RS10430 spd_1971 Glycoside hydrolase family...”
- Streptococcus pneumoniae metal homeostasis alters cellular metabolism
Burcham, Metallomics : integrated biometal science 2020 - “...AgaB SP_RS00340 galactosamine PTS system transporter subunit IIB 3.3 GatB SP_RS03160 Galactose PTS 2.0 AdhB SP_RS01400 alcohol dehydrogenase (zinc) 2.0 NanU SP_RS08315 N-acetylneuraminate ABC transporter substrate-binding protein 2.0 NanE SP_RS08325 N-acetylmannosamine-6-phosphate-2-epimerase 1.4 RaiA SP_RS11265 ribosomal subunit interface protein 1.3 AdhE SP_RS10245 alcohol dehydrogenase (iron) 4.8 RpiA...”
Q9P6C8 alcohol dehydrogenase (EC 1.1.1.1) from Neurospora crassa (see paper)
44% identity, 97% coverage
A1IIA4 alcohol dehydrogenase (EC 1.1.1.1) from Kluyveromyces marxianus (see paper)
43% identity, 90% coverage
A8AVS1 Alcohol dehydrogenase from Streptococcus gordonii (strain Challis / ATCC 35105 / BCRC 15272 / CH1 / DL1 / V288)
SGO_0565 alcohol dehydrogenase from Streptococcus gordonii str. Challis substr. CH1
44% identity, 98% coverage
- Intracellular Ser/Thr/Tyr phosphoproteome of the oral commensal Streptococcus gordonii DL1
Robertsson, BMC microbiology 2020 - “...28% + ldh-3 5.8/5.24 36,000/35267 641 8 32% - adh a) Alcohol dehydrogenase adhA (SGO_0565) A8AVS1 5.2/4.94 39,000/35958 911 13 69% pox Pyruvate oxidase spxB (SGO_0292) A8AV01 5.3/5.06 65,000/65283 161 3 5% Pentose phosphate pathway deob Phosphopentomutase deoB (SGO_1264) A8AXN8 5.3/4.96 47,000/44508 172 3 9% +...”
- Intracellular Ser/Thr/Tyr phosphoproteome of the oral commensal Streptococcus gordonii DL1
Robertsson, BMC microbiology 2020 - “...6 28% + ldh-3 5.8/5.24 36,000/35267 641 8 32% - adh a) Alcohol dehydrogenase adhA (SGO_0565) A8AVS1 5.2/4.94 39,000/35958 911 13 69% pox Pyruvate oxidase spxB (SGO_0292) A8AV01 5.3/5.06 65,000/65283 161 3 5% Pentose phosphate pathway deob Phosphopentomutase deoB (SGO_1264) A8AXN8 5.3/4.96 47,000/44508 172 3 9%...”
- Multiple alcohol dehydrogenases but no functional acetaldehyde dehydrogenase causing excessive acetaldehyde production from ethanol by oral streptococci
Pavlova, Microbiology (Reading, England) 2013 - “...Sgo-841-R1 Sequence of DadhA (SGO_0565) AAGTTTGAGGAACCTTGATGAT CGTAGGATCCCTTCGTGACCAAGGAT ATGAGACTTTGGCATGAGGCC of DadhB (SGO_1774) GCCTTTATTTCCGACGACCGCG...”
- “...et al., 2007), we have identified three genes: adhA (SGO_0565; 1023 bp), adhB (SGO_1774; 1038 bp), and adhE (acdH, SGO_0113; 2652 bp) that encode putative ADHs....”
KLMA_20158 alcohol dehydrogenase ADH3 from Kluyveromyces marxianus DMKU3-1042
43% identity, 90% coverage
- CRISPR-Cas9-enabled genetic disruptions for understanding ethanol and ethyl acetate biosynthesis in Kluyveromyces marxianus
Löbs, Biotechnology for biofuels 2017 - “...interest were identified in the annotated genome of K. marxianus DMKU3-1042 as KLMA_40102, KLMA_40220, KLMA_80306, KLMA_20158, KLMA_20005 KLMA_80339, and KLMA_40624 for Km ADH17, respectively and KLMA_30203 for Km ATF [ 19 ]. Blast searches confirmed the presences of each gene in the unannotated genome of CBS...”
- Genetic basis of the highly efficient yeast Kluyveromyces marxianus: complete genome sequence and transcriptome analyses
Lertwattanasakul, Biotechnology for biofuels 2015 - “...KLMA_40220 Alcohol dehydrogenase 2 ADH2 KLMA_80306 Alcohol dehydrogenase 3 ADH3 KLMA_20005 Alcohol dehydrogenase 4a ADH4a KLMA_20158 Alcohol dehydrogenase 4b ADH4b KLMA_40624 Alcohol dehydrogenase ADH KLMA_80339 Alcohol dehydrogenase 6 ADH6 NAD, nicotinamide adenine dinucleotide; NADP, nicotinamide adenine dinucleotide phosphate. Chromosomal segments including 4,277 genes, which retain the...”
PV09_08030 alcohol dehydrogenase 1 from Verruconis gallopava
45% identity, 97% coverage
- Genomics and Virulence of Fonsecaea pugnacius, Agent of Disseminated Chromoblastomycosis
Bombassaro, Frontiers in genetics 2020 - “...03825 Fonsecaea monophora AYO21_00136 AYO21_09571 AYO21_05363 AYO21_04106 AYO21_12165 AYO21_04852 AYO21_01974 AYO21_00578 AYO21_07675 AYO21_04851 Verruconis gallopava PV09_08030 PV09_06763 PV09_04037 PV09_05381 PV09_02442 PV09_02443 PV09_02062 Rhinocladiella mackenziei Z518_08486 Z518_05387 Z518_05995 Z518_05388 Z518_06895 Z518_09726 Z518_00072 Z518_02618 Z518_04953 Z518_04319 Z518_05993 Z518_05386 Z518_09725 (A) Benzyl alcohol dehydrogenase, (B) -carboxy- cis , cis...”
H9ZGN0 alcohol dehydrogenase (EC 1.1.1.1) from Ogataea angusta (see paper)
44% identity, 89% coverage
Q99W07 Alcohol dehydrogenase from Staphylococcus aureus (strain Mu50 / ATCC 700699)
SA0562 alcohol dehydrogenase from Staphylococcus aureus subsp. aureus N315
SAV0605 alcohol dehydrogenase from Staphylococcus aureus subsp. aureus Mu50
EKM74_RS11915 alcohol dehydrogenase AdhP from Staphylococcus aureus
42% identity, 98% coverage
- Structural and Functional Dynamics of Staphylococcus aureus Biofilms and Biofilm Matrix Proteins on Different Clinical Materials
Hiltunen, Microorganisms 2019 - “...Q6GH55 L-lactate dehydrogenase 1L-LDH Q6GK73 D-lactate dehydrogenaseD-LDH Q6GDS2 Alkaline shock protein 23Asp23 Q6GEP7 Alcohol dehydrogenaseADH Q99W07 Trigger factorTf Q6GG30 DNA-directed RNA polymeraseRpoB Q6GJC5 Alkyl hydroperoxide reductaseAhpC Q6GJR7 Alkyl hydroperoxide reductaseAhpF Q6GJR8 Chaperone proteinGroEL Q6GF43 Chaperone proteinDnaK Q6GGC0 Chaperone proteinDnaJ Q6GGC1 10 kDa chaperonin Q6GF42 Universal stress...”
- Activity of Telavancin against Staphylococcus aureus Isolates, Including Those with Decreased Susceptibility to Ceftaroline, from Cystic Fibrosis Patients
Roch, Antimicrobial agents and chemotherapy 2018 - “...664 Seattle_90 acuC SA1556 NAD-independent protein deacetylase AcuC A>T A>T A>T A>T A>T I159L adh1 SA0562 Alcohol dehydrogenase G>T G>T G>T G>T G>T K325N ald SA1531 Alanine dehydrogenase G>A G>A G>A G>A G>A S126L capB SA0145 Capsular polysaccharide synthesis enzyme Cap5A T>C T>C T>C T>C T>C...”
- Sulfide Homeostasis and Nitroxyl Intersect via Formation of Reactive Sulfur Species in Staphylococcus aureus
Peng, mSphere 2017 - “...ABC transporter: amino acid (ATPase) + NWMN_0436 SA0430 gltB 3.9 Glutamate synthase, large subunit NWMN_0577 SA0562 adh1 24.5 Alcohol dehydrogenase (eukaryote-like) NWMN_0756 SA0742 clfA 4.1 Clumping factor A NWMN_0758 SA0744 ssp 6.9 Extracellular matrix; plasma binding (cell wall) NWMN_1067 SA1001 4.8 Formyl peptide receptor-like 1 inhibitory...”
- Biofilm matrix exoproteins induce a protective immune response against Staphylococcus aureus biofilm infection
Gil, Infection and immunity 2014 - “...ratiob Exoproteins upregulated under biofilm conditions 15927581c 15926283c SA1813 SA0562 x x x 9.43 5.34 40.43 36.05 140.5 113.51 4.57 10.12 32.8 16.6 x x x...”
- Induction of attachment-independent biofilm formation and repression of Hfq expression by low-fluid-shear culture of Staphylococcus aureus
Castro, Applied and environmental microbiology 2011 - “...(SA0218 and SA0219); adh1, encoding alcohol dehydrogenase (SA0562); ddh, encoding D-lactate dehydrogenase (SA2312); and a hypothetical protein (SA2268). This...”
- “...SA0455 SA2336 clpL 2.35 2.43 3.19 2.17 2.81 SA2312 ddh SA0562 adh1 SA2410 nrdD 2.31 2.27 2.09 SA0102 SA0570 SA0752 SA2268 2.14 2.14 2.07 4.45 argF arcC usp...”
- Characterizing the effects of inorganic acid and alkaline shock on the Staphylococcus aureus transcriptome and messenger RNA turnover
Anderson, FEMS immunology and medical microbiology 2010 - “...GTP-binding protein sa_c3349s2883_a_at 8.9 2.5 2.5 leuS SA1808 leucyl-tRNA synthetase sa_c7567s6587_a_at 4.5 2.5 2.5 lysS SA0562 lysyl-tRNA synthetase sa_c7479s6503_a_at 2.9 2.5 2.5 metS SA0533 methionyl-tRNA synthetase sa_c1466s1245_a_at 4.6 2.5 2.5 miaB SA1312 tRNA-i(6)A37 modification enzyme sa_c8764s7707_a_at 4.1 2.5 2.5 pheS SA1148 phenylalanyl-tRNA synthetase sa_c933s729_a_at 4.1 2.5...”
- Characterization of the oxygen-responsive NreABC regulon of Staphylococcus aureus
Schlag, Journal of bacteriology 2008 - “...taga Upregulated genes SA0143 SA0183 SA0232 SA0477 SA0478 SA0562 SA0588 SA0589 SA1140 SA1149 SA1150 SA1183 SA1269 SA1270 SA1271 SA1506 SA1709 SA2007 SA2008...”
- Global regulatory impact of ClpP protease of Staphylococcus aureus on regulons involved in virulence, oxidative stress response, autolysis, and DNA repair
Michel, Journal of bacteriology 2006 - “...Berkeley Down-regulated SA0143 SA0218-SA0219e SA0232 SA0293 SA0295 SA0562 SA0641 SA1272 SA1813 Gene name GLOBAL REGULATION OF S. AUREUS GENES BY clpP...”
- Coordinated regulation of transcription by CcpA and the Staphylococcus aureus two-component system HptRS
Reed, PloS one 2018 - “...for RT-qPCR 16S-RTF SAVrRNA16 GTGGAGGGTCATTGGAAACT 16S-RTR: SAVrRNA16 CACTGGTGTTCCTCCATATCTC pflB-F SAV0226 ACGACTTCAACACGATGTCTAC pflB-R SAV0226 TTCTGCTGGACGGCTTAAAT ADH-F SAV0605 AATTGGAGACCGTGTGTCTATC ADH-R SAV0605 TTCAGCCATTGCACCATCTA rocA-F SAV2554 GCTGAAATGGGTGGTAAAGATG rocA-R SAV2554 CCAAACGCTGACGTTACAATAG DHA-1439F SAV1439 GCTATTGACCAAGGTGGAACTA DHA-1439R SAV1439 GGACTGCTCCTGGTTGATTT ccpA4F SAV1736 CAGGAACAAATGGTAAGGATGC ccpA4R SAV1736 TCTCCACCTACTAAAGCAAATGA uhpTA2-F SAV0222 CCCATCGGTGATTGCATTACT uhpTA2-R SAV0222 CCGGCTCTTCCCAAATTTCT SAV0225RTF SAV0225...”
- The SAV1322 gene from Staphylococcus aureus: genomic and proteomic approaches to identification and characterization of gene function
Kim, BMC microbiology 2016 - “...Up A078 gi|15925115 Fructose-bisphosphate aldolase 62 fbaA SAV2125 Up A281 gi|15923595 Alcohol dehydrogenase 1305 Adh SAV0605 Up Lipid metabolism A027 gi|15924291 Glycerol kinase 1037 glpK SAV1301 Down A054 gi|15923640 Dihydroxyacetone kinase subunit DhaK 420 SAV0650 Down A067 gi|15924001 Enoyl-(acyl carrier protein) reductase 526 fabI SAV1011 Down...”
- Staphylococcus aureus virulence expression is impaired by Lactococcus lactis in mixed cultures
Even, Applied and environmental microbiology 2009 - “...SAV2644 MW2565 Carbohydrate metabolism genes SAV1698 SAV1697 SAV2609 SAV0605 SAV1149 Gene named gpsA cdsA pbp4 dltD MW1642 MW1641 MW2528 MW0568 MW1032 pfk pykA...”
- Transcriptomic Analysis Revealed Antimicrobial Mechanisms of Lactobacillus rhamnosus SCB0119 against Escherichia coli and Staphylococcus aureus
Peng, International journal of molecular sciences 2022 - “...rhamnosus SCB0119. Gene ID RPKM Control RPKM CFS log2 Ratio Gene Annotation Fatty acid degradation EKM74_RS11915 1832.07 490.15 697.14 121.09 1.39396 adhP ; alcohol dehydrogenase DNA replication EKM74_RS04795 85.2 44.94 39.85 1.91 1.09611 single-stranded DNA-binding protein Ribosome EKM74_RS01000 77.06 19.54 474.46 30.77 2.622215 accC ; acetyl-CoA...”
XP_500087 YALI0A15147p from Yarrowia lipolytica CLIB122
44% identity, 98% coverage
B6UQD0 alcohol dehydrogenase (EC 1.1.1.1) from Saccharomyces pastorianus (see 2 papers)
43% identity, 98% coverage
A0A060TBM3 alcohol dehydrogenase (EC 1.1.1.1) from Blastobotrys adeninivorans (see paper)
45% identity, 98% coverage
CH51_RS03355, MW0568, SAOV_0640 alcohol dehydrogenase AdhP from Staphylococcus aureus subsp. aureus ED133
Q2FJ31 Alcohol dehydrogenase from Staphylococcus aureus (strain USA300)
Q2G0G1 Alcohol dehydrogenase from Staphylococcus aureus (strain NCTC 8325 / PS 47)
SAOUHSC_00608 alcohol dehydrogenase I, putative from Staphylococcus aureus subsp. aureus NCTC 8325
SAUSA300_0594 alcohol dehydrogenase from Staphylococcus aureus subsp. aureus USA300_FPR3757
NP_645385 alcohol dehydrogenase I from Staphylococcus aureus subsp. aureus MW2
NWMN_0577 alcohol dehydrogenase from Staphylococcus aureus subsp. aureus str. Newman
USA300HOU_0610 alcohol dehydrogenase from Staphylococcus aureus subsp. aureus USA300_TCH1516
SACOL0660 alcohol dehydrogenase, zinc-containing from Staphylococcus aureus subsp. aureus COL
42% identity, 98% coverage
- Staphylococcus aureus PhoU Homologs Regulate Persister Formation and Virulence
Shang, Frontiers in microbiology 2020 - “...reductase 2.32 ND CH51_RS09730 Acetate-CoA ligase 2.31 ND CH51_RS14750 Acetyl-CoA synthetase 2.17 1.91 0.61 Glycolysis/gluconeogenesis CH51_RS03355 Zinc-dependent alcohol dehydrogenase 0.24 ND CH51_RS10975 Aldehyde dehydrogenase 2.84 ND CH51_RS09730 Acetate-CoA ligase 2.31 ND CH51_RS14750 Acetyl-CoA synthetase 2.17 ND CH51_RS00775 Aldehyde dehydrogenase 2.02 ND Propanoate metabolism CH51_RS08625 Alpha-ketoacid dehydrogenase...”
- “...dehydrogenase 3.11 ND CH51_RS01035 Pyruvate formate lyase 2.71 ND CH51_RS14750 2-Isopropylmalate synthase 0.49 ND Glycolysis/gluconeogenesis CH51_RS03355 Alcohol dehydrogenase 3.35 ND Pentose and glucuronate interconversions CH51_RS01190 2-C-Methyl-D-erythritol 4-phosphate cytidylyltransferase 0.39 ND CH51_RS01195 Alcohol dehydrogenase 0.47 ND Purine metabolism CH51_RS05420 5-(carboxyamino)imidazole ribonucleotide mutase 4.99 ND CH51_RS06845 Polyribonucleotide nucleotidyltransferase...”
- Staphylococcus aureus seroproteomes discriminate ruminant isolates causing mild or severe mastitis
Le, Veterinary research 2011 - “...9,51 27969 1385,18 69,32 22 22,31 S S Miscellaneous adhA alcohol dehydrogenase 100 011_1554 046_0086 SAOV_0640 5,34 36025 1167,82 66,37 16 4,30 CW C [ 87 , 93 ] exported secretory antigen precursor 67 011_0584 046_1132 SAOV_2343 5,77 17388 397,17 33,13 5 1,43 S S lip...”
- The SaeR/S gene regulatory system is essential for innate immune evasion by Staphylococcus aureus
Voyich, The Journal of infectious diseases 2009 - “...glycerol ester hydrolase 4.09 & 3.00 ME & ES MW0394 set26 exotoxin homolog 16.46 ME MW0568 adh1 alcohol dehydrogenase 1.65 & 4.34 ME & ES MW0667 saeS histidine protein kinase absent & absent ME & ES MW0668 saeR response regulator 459.94 & absent ME & ES...”
- Staphylococcus aureus virulence expression is impaired by Lactococcus lactis in mixed cultures
Even, Applied and environmental microbiology 2009 - “...named gpsA cdsA pbp4 dltD MW1642 MW1641 MW2528 MW0568 MW1032 pfk pykA SAV0269 SAV0214 MW0245 MW0190 rbsD SAV2158 SAV0189 SAV2323 SAV0474 MW2084 MW0163 MW2244...”
- S. aureus Biofilm Protein Expression Linked to Antimicrobial Resistance: A Proteomic Study
Piras, Animals : an open access journal from MDPI 2021 - “...N of Matched Peptides Regulation in Sessile vs. Planktonic High Biofilm Producers (Sessile vs. Planktonic) Q2FJ31 ADH_STAA3 820 alcohol dehydrogenase 66 35 9/59 0.070 0.018 A7X656 GPMA_STAA1 824 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase OS = Staphylococcus aureus 116 51 11/52 0.001 0.016 P0A0H0 RS12_STAA8 836 30S ribosomal protein...”
- Isotopically Labeled Desthiobiotin Azide (isoDTB) Tags Enable Global Profiling of the Bacterial Cysteinome
Zanon, Angewandte Chemie (International ed. in English) 2020 - “...MnmG (UniProt code Q2FUQ3)) or metalbinding sites (e.g. C145 of alcohol dehydrogenase Adh (UniProt code Q2G0G1), and C65 of biotin synthase BioB (UniProt code Q2FVJ7)). Therefore, residuespecific proteomics using our isoDTB tags allowed global profiling of the reactivity of cysteines in the bacterial proteome and enabled...”
- A Small Membrane Stabilizing Protein Critical to the Pathogenicity of Staphylococcus aureus
Duggan, Infection and immunity 2020 - “...protein ClpB 2.5 0.001 Q2G087 hisC Histidinol-phosphate aminotransferase 2.6 0.047 Q2G1C9 Uncharacterized protein 2.6 <0.0001 Q2G0G1 adh Alcohol dehydrogenase 2.8 0.017 Q2FWN9 Uncharacterized leukocidin-like protein 2 2.9 <0.0001 Q2G1C8 Uncharacterized protein 3.0 <0.0001 Q2G1D0 Acetyl-coenzyme A acetyltransferase 4.4 0.003 Q2G1K9 Aldehyde-alcohol dehydrogenase 4.6 0.001 Q2FWP0 Uncharacterized...”
- Copper stress in Staphylococcus aureus leads to adaptive changes in central carbon metabolism
Tarrant, Metallomics : integrated biometal science 2019 - “...0.4 0.00011 Putative formate dehydrogenase subunit alpha fdhA SAOUHSC_02582 gi|123406992 0.4 0.00046 Alcohol dehydrogenase adhA SAOUHSC_00608 gi|122540071 0.3 <0.00010 Formate acetyltransferase pflB SAOUHSC_00187 gi|446817404 0.1 <0.00010 Bifunctional acetaldehyde-CoA/alcohol dehydrogenase adhE SAOUHSC_00113 gi|88193926 0.1 <0.00010 Leukocidin-like protein 2 lukH SAOUHSC_02243 gi|122539025 0.1 <0.00010 Leukocidin-like protein 1 lukG...”
- Functional analysis of the EsaB component of the Staphylococcus aureus Type VII secretion system
Casabona, Microbiology (Reading, England) 2017 - “...protein CapF ns SAOUHSC_02463 hysA 4.3 Hyaluronate lyase ns SAOUHSC_02453 lacC 4.1 Tagatose-6-phosphate kinase 2.2 SAOUHSC_00608 adh1 4.1 Alcohol dehydrogenase ns Upregulated genes SAOUHSC_02767 opp-1A 4.0 Peptide ABC transporter substrate-binding protein 2.6 SAOUHSC_02655 4.2 Unknown, hypothetical protein 6.3 SAOUHSC_01292 4.4 Putative DNA-binding protein ns SAOUHSC_00130 isdI...”
- Alternative Evolutionary Pathways for Drug-Resistant Small Colony Variant Mutants in Staphylococcus aureus
Cao, mBio 2017 - “...b srrB vs SCV c Pyruvate fermentation SAOUHSC_00113, adhE Alcohol dehydrogenase 2.1 3.2 3.3 1.6 SAOUHSC_00608, adh1 Alcohol dehydrogenase I 3.1 3.3 3.6 3.5 SAOUHSC_00206, ldh1 l -Lactate dehydrogenase 6.8 0.2 0.3 3.4 SAOUHSC_02922, ldh2 l -Lactate dehydrogenase 0.6 2.9 2.8 0.8 SAOUHSC_00188, pflA Pyruvate formate-lyase...”
- Redox sensing by a Rex-family repressor is involved in the regulation of anaerobic gene expression in Staphylococcus aureus
Pagels, Molecular microbiology 2010 - “...12.4 (11.7) SACOL0204 5 0.9 (0.5) 5.1 (2.6) 0.1 (0.1) 43.2 (43.1) 7.9 (8.1) SACOL0204 SAOUHSC_00608 Adh1 + 2.5 (5.2) 9.1 (3.2) 0.8 (0.7) 11 (4.4) 3 (7.2) SACOL0660 Alcohol dehydrogenase Class III proteins SAOUHSC_00375 GuaA 1 (1.6) 2.4 (4.9) 1.5 (1.9) 1.6 (2.7) 0.6 (0.9)...”
- Roles of the Site 2 Protease Eep in Staphylococcus aureus
Cheng, Journal of bacteriology 2020 (secret) - Proteome Analyses of Staphylococcus aureus Biofilm at Elevated Levels of NaCl
Islam, Clinical microbiology (Los Angeles, Calif.) 2015 - “...926 Alcohol dehydrogenase/adh1 Catalysis of rection related to alcohol to produce energy 320 5.2/36 65 NP_645385 941 2-amino-3-keto butyrate coenzyme A ligase/MW0505 Glycine, serine and threonine metabolism 198 5.1/43 46 NP_645322 942 Coenzyme A disulfide reductase/cdr Catalyzes specifically the NADPH-dependent reduction 138 5.2/49 38 O52582...”
- Sulfide Homeostasis and Nitroxyl Intersect via Formation of Reactive Sulfur Species in Staphylococcus aureus
Peng, mSphere 2017 - “...3.6 ABC transporter: amino acid (ATPase) + NWMN_0436 SA0430 gltB 3.9 Glutamate synthase, large subunit NWMN_0577 SA0562 adh1 24.5 Alcohol dehydrogenase (eukaryote-like) NWMN_0756 SA0742 clfA 4.1 Clumping factor A NWMN_0758 SA0744 ssp 6.9 Extracellular matrix; plasma binding (cell wall) NWMN_1067 SA1001 4.8 Formyl peptide receptor-like 1...”
- Analysis of the Staphylococcus aureus abscess proteome identifies antimicrobial host proteins and bacterial stress responses at the host-pathogen interface
Attia, Pathogens and disease 2013 - “...g Mean d , h SD e Mean d SD e Glycolysis/gluconeogenesis Alcohol dehydrogenase Adh1 NWMN_0577 9 5.14 124 23.41 13.28 0.0012 L-lactate dehydrogenase 2 Ldh NWMN_2499 8 3.61 25 9.09 2.96 0.0425 Enolase Eno NWMN_0745 1 0.00 24 5.18 23.77 0.0014 Glyceraldehyde 3-phosphate dehydrogenase 1...”
- Staphylococcus aureus fur regulates the expression of virulence factors that contribute to the pathogenesis of pneumonia
Torres, Infection and immunity 2010 - “...2.10E05 1.30E05 NWMN_2499 34.5 4.8 62 4 3 13 5.60 1.90E04 NWMN_1167 NWMN_0577 NWMN_0475 NWMN_0041 32.5 36.4 33 35 5.2 5.5 5.2 6.5 177 52 43 78 12 5 3 10 (1) 5 3...”
- Protein S-Bacillithiolation Functions in Thiol Protection and Redox Regulation of the Glyceraldehyde-3-Phosphate Dehydrogenase Gap in Staphylococcus aureus Under Hypochlorite Stress
Imber, Antioxidants & redox signaling 2018 - “...0.18 USA300HOU_1684 pykA Pyruvate kinase Cys266 a B 1.7 10.52 11.24 0.31 21.76 0.11 Fermentation USA300HOU_0610 adh Alcohol DH Cys34 B 4.1 25.18 11.02 0.35 36.20 0.28 USA300HOU_0610 adh Alcohol DH Cys37 a B 2.3 25.18 11.02 0.35 36.20 0.28 USA300HOU_2110 aldA Aldehyde DH Cys279 a...”
- “...at conserved Zn-binding sites. Examples for Zn redox switches are the Zn-containing alcohol dehydrogenase Adh (USA300HOU_0610), the ribosomal proteins RpmG3 (USA300HOU_1553), and RpmJ (USA300HOU_2218). Zn-containing ribosomal proteins share three to four Cys residues that are suggested to serve as reservoir for Zn storage ( 54 )....”
- Transcriptomic and Metabolomic Analysis of a Fusidic Acid-Selected fusA Mutant of Staphylococcus aureus
Gupta, Antibiotics (Basel, Switzerland) 2022 - “...via microarray. Fold-Change in Gene Expression Gene Locus Microarray RT-PCR cap5E SACOL0140 10.4 2.1 adh1 SACOL0660 7.0 4.3 crtN SACOL2576 2.4 2.4 ddh SACOL2535 12.2 23.6 spa SACOL0095 8.9 1448.0 antibiotics-11-01051-t003_Table 3 Table 3 Functional category gene expression differences in SH10001st-2 compared to SH1000. Functional Category...”
- Apt (Adenine Phosphoribosyltransferase) Mutation in Laboratory-Selected Vancomycin-Intermediate Staphylococcus aureus
Lamichhane-Khadka, Antibiotics (Basel, Switzerland) 2021 - “...time-PCR (qRT-PCR) confirmed the orientation of transcriptional alteration indicated by microarray analysis in 8 genes (SACOL0660, SACOL1080, SACOL2054, SACOL2182, SACOL0209, SACOL1173 and SACOL2418) ( Table 2 ). The S. aureus lacEFG encodes the lactose-specific transport components and -galactosidase [ 29 , 30 ]. The highest upregulated...”
- “...genes SACOL0136 cap5A Capsular polysaccharide biosynthesis 2.9 4 SACOL0137 cap5B Capsular polysaccharide biosynthesis ND 2.7 SACOL0660 adhP Alcohol dehydrogenase 2.1 (1.2) 2.3 (3.9) SACOL0781 opuAC Osmoprotectant ABC transporter component ND 2.3 SACOL0856 clfA Clumping factor A 2.1 ND SACOL1078 purL Phosphoribosylformylglycinamidine synthase II 2.2 2.2 SACOL1079...”
- Virulence and Metabolism
Richardson, Microbiology spectrum 2019 (secret) - Identification of Staphylococcus aureus Cellular Pathways Affected by the Stilbenoid Lead Drug SK-03-92 Using a Microarray
Schwan, Antibiotics (Basel, Switzerland) 2017 - “...potential mechanism of action for SK-03-92 included glpD , adhE ( SACOL0135 ), adhP ( SACOL0660 ), and sdhC ( SACOL1158 ). GlpD funnels electrons into the respiratory chain via quinone or menaquinone reduction coupled to the oxidation of glycerol-3-phosphate to glycerone phosphate (dihydroxyacetone phosphate) [...”
- “...aerobic glyerol-3-phosphate dehydrogenase ( glpD ) Catabolism SACOL0135 2.4 alcohol dehydrogenase, iron-containing ( adhE ) SACOL0660 3.4 alcohol dehydrogenase, zinc-containing ( adhA ) SACOL1158 2.5 succinate dehydrogenase, cytochrome b558 subunit ( sdhC ) SACOL1604 2.1 glucokinase ( glk ) SACOL2338 3.5 hypothetical protein (putative oxidoreductase) SACOL1713...”
- Identification of commonly expressed exoproteins and proteolytic cleavage events by proteomic mining of clinically relevant UK isolates of Staphylococcus aureus
Smith, Microbial genomics 2016 - “...C SACOL0460 Inosine-5-monophosphate dehydrogenase C SACOL0593 Elongation factor G C SACOL0594 Elongation factor Tu C SACOL0660 Alcohol dehydrogenase C SACOL0838 Glyceraldehyde 3-phosphate dehydrogenase C SACOL0839 Phosphoglycerate kinase C SACOL0842 Phosphopyruvate hydratase C SACOL1092 Phosphoenolpyruvate-protein phosphotransferase C SACOL1102 Pyruvate dehydrogenase complex E1 component, alpha subunit C SACOL1104...”
- Protecs, a comprehensive and powerful storage and analysis system for OMICS data, applied for profiling the anaerobiosis response of Staphylococcus aureus COL
Fuchs, Proteomics 2010 (PubMed)- “...an induction of fermentation enzymes (PflB, Ldh1, SACOL0135, SACOL0660) as well as the response regulator SrrA. Interestingly, especially genes with a high...”
- “...Pta Acetyl-CoA SACOL0135 IlvB SACOL0241 BudA1 acetoin SACOL0660 ethanol SACOL0111 FumC Icd fumarate SdhA SdhB SdhC 2,3-butanediol oxoglutarate succinate SucC...”
- Redox sensing by a Rex-family repressor is involved in the regulation of anaerobic gene expression in Staphylococcus aureus
Pagels, Molecular microbiology 2010 - “...SACOL0301 (nirC) Formate/nitrite transporter family protein 51 Shift SACOL1478 ald1 Alanine dehydrogenase 38 Shift Up SACOL0660 (adh1) Alcohol dehydrogenase 306 Shift Up Up SACOL1535 srrA DNA-binding response regulator SrrA 103 Shift No change Up SACOL2535 (ddh) d -isomer specific 2-hydroxyacid dehydrogenase family protein 102 Shift SACOL2534...”
- “...(8.1) SACOL0204 SAOUHSC_00608 Adh1 + 2.5 (5.2) 9.1 (3.2) 0.8 (0.7) 11 (4.4) 3 (7.2) SACOL0660 Alcohol dehydrogenase Class III proteins SAOUHSC_00375 GuaA 1 (1.6) 2.4 (4.9) 1.5 (1.9) 1.6 (2.7) 0.6 (0.9) SACOL0461 GMP synthase/glutamine amidotransferase protein SAOUHSC_00535 1.3 (1.6) 3.3 (2.2) 1.1 (1.5) 2.9...”
- Genetic changes that correlate with the pine-oil disinfectant-reduced susceptibility mechanism of Staphylococcus aureus
Lamichhane-Khadka, Journal of applied microbiology 2008 - “...) ( Table 2 ), compared to COL. These two Adhs are similar in size (SACOL0660 336 aa and SACOL2367 335 aa) yet only demonstrate 22% identity along their lengths and are unrelated to AdhE. Nine hundred and forty one bp from the mutation site in...”
- “...pflB SACOL0204 formate acetyltransferase 2.46 2.0 cap5E SACOL0140 capsular polysachharide biosynthesis protein 2.51 2.9 adh2 SACOL0660 alcohol dehydrogenase, zinc containing 2.24 2.5 SACOL2553 pyruvate oxidase 2.16 mtlD SACOL2149 mannitol-1-phosphate 5-dehydrogenase 2.09 SACOL0220 putative flavohemoprotein 2.06 pyrB SACOL1212 aspartate carbamoyltransferase 2.04 SACOL2605 conserved hypothetical protein 1.97 SACOL2148...”
- More
KLMA_40220 alcohol dehydrogenase 2 from Kluyveromyces marxianus DMKU3-1042
43% identity, 98% coverage
- CRISPR-Cas9-enabled genetic disruptions for understanding ethanol and ethyl acetate biosynthesis in Kluyveromyces marxianus
Löbs, Biotechnology for biofuels 2017 - “...genes of interest were identified in the annotated genome of K. marxianus DMKU3-1042 as KLMA_40102, KLMA_40220, KLMA_80306, KLMA_20158, KLMA_20005 KLMA_80339, and KLMA_40624 for Km ADH17, respectively and KLMA_30203 for Km ATF [ 19 ]. Blast searches confirmed the presences of each gene in the unannotated genome...”
- Genetic basis of the highly efficient yeast Kluyveromyces marxianus: complete genome sequence and transcriptome analyses
Lertwattanasakul, Biotechnology for biofuels 2015 - “...KLMA_50517 Endo-1,3(4)-beta-glucanase 2 ACF2 KLMA_10518 Inulinase INU1 Sucrose, raffinose, inulin KLMA_40102 Alcohol dehydrogenase 1 ADH1 KLMA_40220 Alcohol dehydrogenase 2 ADH2 KLMA_80306 Alcohol dehydrogenase 3 ADH3 KLMA_20005 Alcohol dehydrogenase 4a ADH4a KLMA_20158 Alcohol dehydrogenase 4b ADH4b KLMA_40624 Alcohol dehydrogenase ADH KLMA_80339 Alcohol dehydrogenase 6 ADH6 NAD, nicotinamide...”
XP_447590 hypothetical protein from Candida glabrata CBS 138
42% identity, 96% coverage
- Characteristics of Extracellular Vesicles Released by the Pathogenic Yeast-Like Fungi Candida glabrata, Candida parapsilosis and Candida tropicalis
Karkowska-Kuleta, Cells 2020 - “...+ + + gi|50290013 (XP_447438) CAGL0I04356g translation initiation factor eIF4A (Tif1) + + + gi|50290317 (XP_447590) CAGL0I07843g alcohol dehydrogenase I (Adh1) + + + gi|50291073 (XP_447969) CAGL0J06050g secreted glycoprotein (Ygp1) + + gi|50292035 (XP_448450) CAGL0K05137g vacuolar acid trehalase precursor (Ath1) + + + gi|50292597 (XP_448731) CAGL0K11858g...”
- Moonlighting proteins are variably exposed at the cell surfaces of Candida glabrata, Candida parapsilosis and Candida tropicalis under certain growth conditions
Karkowska-Kuleta, BMC microbiology 2019 - “...0.03771 gi|50,289,591 (XP_447227) uncharacterized protein CAGL0H09878g [ Candida glabrata ] inorganic pirophosphatase (Ipp1) 0.03773 gi|50,290,317 (XP_447590) uncharacterized protein CAGL0I07843g [ Candida glabrata ] alcohol dehydrogenase I (Adh1) 0.04322 0.03855 gi|50,291,871 (XP_448368) uncharacterized protein CAGL0K03289g [ Candida glabrata ] glucose-6-phosphate 1-epimerase (Gpe1) 0.00787 gi|50,292,233 (XP_448549) uncharacterized protein...”
ZMO1236 alcohol dehydrogenase from Zymomonas mobilis subsp. mobilis ZM4
ZMO_RS05560 alcohol dehydrogenase AdhP from Zymomonas mobilis subsp. mobilis ZM4 = ATCC 31821
43% identity, 98% coverage
- Expression and characterization of monofunctional alcohol dehydrogenase enzymes in Clostridium thermocellum
Chiarelli, Metabolic engineering communications 2024 - “...60100 Atomi and Reeve (2019) AP006878 Tk1008 Zymomonas mobilis 2536 Li et al. (2021) AE008692 Zmo1236 Zmo1596 ( adhB ) Zmo1771 2.2 Strains and plasmids Genes from Table 1 were synthesized and cloned into the pDGO143 plasmid backbone (Accession Number: KX259110.1 )( Hon et al., 2016...”
- “...Zmo1596 ( adhB ), which could not be transformed into strain LL1711. The Ta1316 and Zmo1236 proteins both share a relatively distinct domain structure, and also reduced ethanol yield. Fig. 5 Neighbor-joining consensus tree inferred using ADH protein sequences. Node numbers refer to NJ bootstrap proportions...”
- Characterization and Application of the Sugar Transporter Zmo0293 from Zymomonas mobilis
Zhang, International journal of molecular sciences 2023 - “...0.98 to 0.8 and 0.78. Although most ED pathway genes possess the same expression level, ZMO1236 ( adhA , encoding alcohol dehydrogenase), ZMO1237 ( ldhA , encoding D-lactate dehydrogenase), ZMO1570 ( pflB , encoding formate acetyltransferase), ZMO0178 ( pgk , encoding phosphoglycerate kinase), ZMO1240 ( gpmA...”
- “...1.02 1.85 0.27 1 3.29 5.13 ZMO0369 glk glucokinase 1 0.22 0.09 1.01 0.45 1.68 ZMO1236 adhA alcohol dehydrogenase 1 0.96 0.59 1 0.23 1.32 ZMO1237 ldhA D-Lactate dehydrogenase 1.06 0.9 0.51 1 0.97 6.14 ZM01754 ssdA aldehyde dehydrogenase (NAD + ) 1.05 1.14 0.73 1...”
- Investigation of the impact of a broad range of temperatures on the physiological and transcriptional profiles of Zymomonas mobilis ZM4 for high-temperature-tolerant recombinant strain development
Li, Biotechnology for biofuels 2021 - “...ions ( ZMO0423 , ZMO0428 , ZMO0429 , and ZMO1596 ) and zinc ions ( ZMO1236 and ZMO1341 ) were up-regulated at high temperature. These results suggested that cells may up-regulate genes associated with TonB system and transporters of important nutrients to maintain normal cell metabolism...”
- Development and characterization of acidic-pH-tolerant mutants of Zymomonas mobilis through adaptation and next-generation sequencing-based genome resequencing and RNA-Seq
Yang, Biotechnology for biofuels 2020 - “...that four genes involved in the glycolysis pathway, ZMO1478 (pgl), ZMO1240 (gpmA), ZMO1596 (adhB), and ZMO1236 (adhA) , were significantly upregulated at the acidic pH 3.8 compared to a neutral pH 6.2 in ZM4 and 3.6M. Another three genes involved in glycolysis pathway, ZMO0997 (eda), ZMO0177...”
- Metabolic engineering of Zymomonas mobilis for anaerobic isobutanol production
Qiu, Biotechnology for biofuels 2020 - “...several alcohol dehydrogenases were also identified in Z. mobilis including a Zn-dependent alcohol dehydrogenase AdhA (ZMO1236); iron-containing alcohol dehydrogenases AdhB (ZMO1593) and ZMO1771; a Zn-dependent alcohol dehydrogenase class III AdhC (ZMO1722); and a plasmid-borne alcohol dehydrogenase-like protein (pZYM33_021). Fig.2 Isobutanol biosynthesis pathway and associated enzymes for...”
- Transcriptomic Profiles of Zymomonas mobilis 8b to Furfural Acute and Long-Term Stress in Both Glucose and Xylose Conditions
Yang, Frontiers in microbiology 2020 - “...acetate, was up-regulated 4 folds, and an iron-containing group III alcohol dehydrogenase (AdhA) encoded by ZMO1236 involving in oxidization of ethanol into acetaldehyde ( Kalnenieks et al., 2002 ; Kalnenieks et al., 2006 ) was also up-regulated about threefolds ( Supplementary Tables S5-1 , S5-2 )....”
- Genome Wide Phosphoproteome Analysis of Zymomonas mobilis Under Anaerobic, Aerobic, and N2-Fixing Conditions
Tatli, Frontiers in microbiology 2019 - “...produced from glucose into ethanol via pyruvate decarboxylase (PDC, ZMO1360) and alcohol dehydrogenase (ADH 1, ZMO1236; ADH 2, ZMO1596) ( Figure 3A ; Panesar et al., 2006 ). FIGURE 3 Phosphorylation of central carbon metabolic enzymes. (A) The EntnerDoudoroff glycolytic pathway, TCA cycle, and ethanol fermentation...”
- Complete genome sequence and the expression pattern of plasmids of the model ethanologen Zymomonas mobilis ZM4 and its xylose-utilizing derivatives 8b and 2032
Yang, Biotechnology for biofuels 2018 - “...Promoter of ZMO1223 ( fabD ) and ZMO1225 ( rpsF ) C to T 12623261262326 ZMO1236 ( adhA ) C to T (A153T) 12633771263378 Promoter of ZMO1236 ( adhA ) and downstream of ZMO1237 ( ldhA ) Missing one base C 12639831269992 ZMO1237 ( ldhA )...”
- More
- Molecular mechanism of engineered Zymomonas mobilis to furfural and acetic acid stress
Shabbir, Microbial cell factories 2023 - “...both strains (Additional file 1 : Tables S7, S8, S9, S10). Moreover, alcohol dehydrogenase encoded ZMO_RS05560, which was up-regulated in both strains, but these genes were doubly expressed in ZM532 compared to ZM4. ZMO_RS03395 (Hydroxyacylglutathione hydrolase), ZMO_RS05445 (glucose-6-phosphate isomerase) and ZMO_RS03970 (galactose-1-epimerase) were up-regulated in ZM532...”
- Improvement of Acetaldehyde Production in Zymomonas mobilis by Engineering of Its Aerobic Metabolism
Kalnenieks, Frontiers in microbiology 2019 - “...ZMO_RS06080 is annotated as encoding alpha-keto acid decarboxylase family protein, ZMO_RS04970 as encoding NAD(P)/FAD-dependent oxidoreductase, ZMO_RS05560 as encoding alcohol dehydrogenase AdhP, while ZMO_RS07165 as encoding L-threonine dehydrogenase. Based on previous publications on the biochemical characteristics of these enzymes and the according nucleotide sequences of the genes...”
- “...ZMO_RS04970 as the respiratory type II NADH dehydrogenase gene, ndh (Kalnenieks et al., 2008 ), ZMO_RS05560 as the ADH I gene, adhA (Keshav et al., 1990 ), and ZMO_RS07165 as the ADH II gene, adhB (Conway et al., 1987b ). Table 2 List of genes and...”
E3UTQ9 allyl-alcohol dehydrogenase (EC 1.1.1.54) from Fusarium oxysporum (see paper)
FOXG_12790 alcohol dehydrogenase 1 from Fusarium oxysporum f. sp. lycopersici 4287
41% identity, 96% coverage
- Gene Regulatory Network Inference and Gene Module Regulating Virulence in Fusarium oxysporum
Cano, Frontiers in microbiology 2022 - “...two DNA half-sites composed of three to five C/G combinations, whereas three proteins, alcohol dehydrogenase (FOXG_12790), glutamate dehydrogenase (FOXG_01626), and non-reducing end alpha-L-arabinofuranosidase (FOXG_02500), were found with the maximum in degree (regulated by 24 TFs each). Figure 1 Gene regulatory network (GRN) of Fusarium oxysporum ....”
- “...(0.0010579) FOXG_03418 (0.05093478) 3 FOXG_01037 (0.11987755) FOXG_02500 (0.00537207) FOXG_01037 (0.0009947) FOXG_01626 (0.0498954) 4 FOXG_04255 (0.0987459) FOXG_12790 (0.00530916) FOXG_05265 (0.0009814) FOXG_00928 (0.0498882) 5 FOXG_05265 (0.09045126) FOXG_03680 (0.0052953) FOXG_04255 (0.0009301) FOXG_12790 (0.04926705) * Between parentheses, the value of centrality of each gene is added, the higher the value,...”
- Proteomic identification of potential target proteins regulated by the SCF(F) (bp1) -mediated proteolysis pathway in Fusarium oxysporum
Miguel-Rojas, Molecular plant pathology 2013 (secret)
ADH1 / P00330 alcohol dehydrogenase 1 (EC 1.1.1.1; EC 1.1.1.190) from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (see 10 papers)
ADH1_YEAST / P00330 Alcohol dehydrogenase 1; Alcohol dehydrogenase I; ADHI; NADH-dependent methylglyoxal reductase; YADH-1; EC 1.1.1.1; EC 1.1.1.54; EC 1.1.1.78 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see 12 papers)
NP_014555, YOL086C Adh1p from Saccharomyces cerevisiae
NP_014555 alcohol dehydrogenase ADH1 from Saccharomyces cerevisiae S288C
42% identity, 98% coverage
- function: Preferentially fermentative isozyme that reduces acetaldehyde to ethanol during the fermentation of glucose. Major enzyme required for the conversion of acetaldehyde to ethanol (Probable) (PubMed:22094012). Plays a key role in the carbohydrate metabolism through the regeneration of NAD(+) from glycolytic NADH (Probable). In the reverse reaction, preferentially catalyzes the conversion of primary unbranched alcohols to their corresponding aldehydes. Also shows activity toward secondary alcohols (Probable). Most active with ethanol, and its activity decreases as the size of the alcohol is increased (PubMed:8463307).
catalytic activity: a primary alcohol + NAD(+) = an aldehyde + NADH + H(+) (RHEA:10736)
catalytic activity: a secondary alcohol + NAD(+) = a ketone + NADH + H(+) (RHEA:10740)
catalytic activity: ethanol + NAD(+) = acetaldehyde + NADH + H(+) (RHEA:25290)
catalytic activity: allyl alcohol + NADP(+) = acrolein + NADPH + H(+) (RHEA:12168)
catalytic activity: 1-propanol + NAD(+) = propanal + NADH + H(+) (RHEA:50704)
catalytic activity: butan-1-ol + NAD(+) = butanal + NADH + H(+) (RHEA:33199)
catalytic activity: hexan-1-ol + NAD(+) = hexanal + NADH + H(+) (RHEA:60972)
catalytic activity: (R)-lactaldehyde + NAD(+) = methylglyoxal + NADH + H(+) (RHEA:24528)
catalytic activity: octan-1-ol + NAD(+) = octanal + NADH + H(+) (RHEA:24620)
catalytic activity: butan-2-ol + NAD(+) = butan-2-one + NADH + H(+) (RHEA:64560)
catalytic activity: propan-2-ol + NAD(+) = acetone + NADH + H(+) (RHEA:41984)
catalytic activity: isobutanol + NAD(+) = 2-methylpropanal + NADH + H(+) (RHEA:64692)
cofactor: Zn(2+) (Binds 2 Zn(2+) ions per subunit.)
subunit: Homotetramer. - Solvent isotope and mutagenesis studies on the proton relay system in yeast alcohol dehydrogenase 1
Plapp, Chemico-biological interactions 2024 (secret) - Changes in a Protein Profile Can Account for the Altered Phenotype of the Yeast Saccharomyces cerevisiae Mutant Lacking the Copper-Zinc Superoxide Dismutase
Kwolek-Mirek, Metabolites 2023 - “...9 1.09 9. YCL018W LEU2 Beta-isopropylmalate dehydrogenase 39.04 38.95 5.48 872 16 15 2.67 10. YOL086C ADH1 Alcohol dehydrogenase I 37.28 36.84 6.67 4286 89 20 9.83 11. YKL060C FBA1 Fructose 1,6-bisphosphate aldolase 39.88 39.61 5.59 1043 18 11 2.05 12. YJR105W ADO1 Adenosine kinase 36.52...”
- Specific base catalysis by yeast alcohol dehydrogenase I with substitutions of histidine-48 by glutamate or serine residues in the proton relay system
Plapp, Chemico-biological interactions 2023 - “...The single stranded template in M13mp18RF phage including the gene for ADH1 ( adc1 , YOL086c, UniProtKB entry P00330) in the yeast shuttle vector YEp13 [ 33 , 34 ] was mutated with the oligonucleotide primer CTGACTT GGAA GCTTGGCAC for the H48E substitution or with the...”
- Metabolic flux sampling predicts strain-dependent differences related to aroma production among commercial wine yeasts
Scott, Microbial cell factories 2021 - “...aminotransferase r_4226 Alanine metabolism ACO2 YJL200C Citrate hydroxymutase r_4262 Citric Acid Cycle ADH5 ADH1 YBR145W YOL086C Alcohol dehydrogenase, (acetaldehyde to ethanol) r_2115 Glycolysis, Fatty acid degradation, Tyrosine metabolism, Biosynthesis of secondary metabolites (Ehrlich pathway) GLO2 YDR272W Hydroxyacylglutathione hydrolase r_0553 Pyruvate metabolism GLO1 YML004C Lactoylglutathione lyase r_0697...”
- The Thr45Gly substitution in yeast alcohol dehydrogenase substantially decreases catalysis, alters pH dependencies, and disrupts the proton relay system
Pal, Chemico-biological interactions 2021 - “...stranded template in M13mp18RF phage derived from the gene for yeast ADH1 ( adc1 , YOL086c, UniProtKB entry P00330) in the yeast shuttle vector YEp13 [ 32 , 33 ] was mutated with the oligonucleotide primer TCTGTCAC GGT GACTTGCA (underline marks the site of mutation) by...”
- Overexpression of THI4 and HAP4 Improves Glucose Metabolism and Ethanol Production in Saccharomyces cerevisiae
Shi, Frontiers in microbiology 2018 - “...TCGATCCTTCCGGGTTCTT R: CGCGGTTCTGCAGATCATG YDL022W GPD1 F: TCAATTTTTGCCCCGTATCTG R: GATAGCTCTGACGTGTGAATCAACA YHL032C GUT1 F: GCCCCAGCTCGTGAAACA R: GGGCTTTCCGCTGGTTTT YOL086C ADH1 F: GAAGGTGCCGGTGTCGTT R: ACCGATCTTCCAGCCCTTAAC YPL061W ALD6 F: GACAAAGTCAACGGTAGAACAATCA R: GGCTCTAAGGTGGTGAAGTTCATG YLR113W HOG1 F: GGGCATTTGGGTTGGTTTG R: TTAATGGCAACTGGCTGAGATG YML120C NDI1 F: GAGGCCGCTGGTGAACTACA R: GCCAATGCAGGGAGAAACTTT YPR002W PDH1 F: CTTACCGTCATGCCCCAAAT R: AGCCCTCGAAACTGCATCTC YER148W...”
- Metschnikowia pulcherrima Influences the Expression of Genes Involved in PDH Bypass and Glyceropyruvic Fermentation in Saccharomyces cerevisiae
Sadoudi, Frontiers in microbiology 2017 - “...TGCGGACTGGTAAATGTGTC 20 ACS2 (YLR153C) 850846 Acetyl-CoA synthase, isozyme 2 ATTGGTCCTTTCGCCTCAC 19 118 GCTGTTCGGCTTCGTTAGA 19 ADH1 (YOL086C) 854068 Alcohol dehydrogenase, isozyme 1 GGTCACTGGGTTGCTATCTCC 21 107 CCTTCACCACCGTCAATACC 20 ADH2 (YMR303C) 855349 Alcohol dehydrogenase, isozyme 2 TGCCCACGGTATCATCAAT 19 98 GCAAACCAACCAAGACAACAG 21 CAT2 (YML042W) 854965 Carnitine acetyltransferase 2 CAAACTGATGACCCATGACG 20...”
- Transcriptional profiling reveals molecular basis and novel genetic targets for improved resistance to multiple fermentation inhibitors in Saccharomyces cerevisiae
Chen, Biotechnology for biofuels 2016 - “...YDL055C, YDR050C, YER001W, YFL045C, YFL053W, YGL179C, YGR282C, YJL153C, YJR096W , YKL201C, YLL026W, YLR286C , YLR300W, YOL086C, YOR099W, YPL053C, YPR160W, YPR165W YEL040W, YFR053C, YGL156W, YGR043C, YGR256W, YJR096W , YLL026W , YLR286C , YML100W, YMR105C, YOR120W, YPR160W YBR001C, YBR105C, YCR005C, YDL055C, YER001W, YFL053W, YFR053C, YGL156W, YGL179C, YGR043C, YGR256W,...”
- “...YKL001C, YKR080W, YLR058C, YLR142W , YLR180W, YLR231C, YLR303W, YMR169C , YMR189W, YMR300C, YNL135C, YNL160W, YOL058W, YOL086C, YOR184W, YOR375C YCL030C, YDR007W, YDR502C , YER091C , YGL245W, YGL256W , YJL200C, YJR016C, YLR142W , YMR169C , YMR250W YCL030C, YCR005C, YDL168W, YDL182W, YDR007W, YDR135C, YDR502C , YDR513W, YEL046C, YER043C, YER091C...”
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- Mechanistic implications from structures of yeast alcohol dehydrogenase complexed with coenzyme and an alcohol.
Plapp, Archives of biochemistry and biophysics 2016 (PubMed)- GeneRIF: Subunit B may represent an intermediate in the mechanism after coenzyme and alcohol bind and before the conformation changes to the closed form and the alcohol oxygen binds to the zinc and displaces Glu-67.
- Glucose 6-phosphate and alcohol dehydrogenase activities are components of dynamic macromolecular depots structures.
Tramonti, Biochimica et biophysica acta 2015 (PubMed)- GeneRIF: Glucose 6-phosphate and alcohol dehydrogenase activities are components of dynamic macromolecular depot structures.
- Furaldehyde substrate specificity and kinetics of Saccharomyces cerevisiae alcohol dehydrogenase 1 variants.
Laadan, Microbial cell factories 2014 - GeneRIF: key role of Y295C mutation in HMF reduction by Adh1p.
- Double mutation of the PDC1 and ADH1 genes improves lactate production in the yeast Saccharomyces cerevisiae expressing the bovine lactate dehydrogenase gene.
Tokuhiro, Applied microbiology and biotechnology 2009 (PubMed)- GeneRIF: mutation of the ADH1 gene improves lactate production in the yeast Saccharomyces cerevisiae
- Identification of an NADH-dependent 5-hydroxymethylfurfural-reducing alcohol dehydrogenase in Saccharomyces cerevisiae.
Laadan, Yeast (Chichester, England) 2008 (PubMed)- GeneRIF: The identification and characterization of a mutated alcohol dehydrogenase 1 from the industrial Saccharomyces cerevisiae strain TMB3000 that mediates the NADH-dependent reduction of 5-hydroxymethylfurfural (HMF) to 2,5-bis-hydroxymethylfuran.
- Mechanism of thermal aggregation of yeast alcohol dehydrogenase I: role of intramolecular chaperone.
Markossian, Biochimica et biophysica acta 2008 (PubMed)- GeneRIF: a sequence -YSGVCHTDLHAWHGDWPLPVK- in the polypeptide chain possesses chaperone-like activity
- The oxidation of yeast alcohol dehydrogenase-1 by hydrogen peroxide in vitro.
Men, Journal of proteome research 2007 (PubMed)- GeneRIF: analysis of the oxidation of yeast alcohol dehydrogenase-1 by hydrogen peroxide in vitro
- Chronological and replicative life-span extension in Saccharomyces cerevisiae by increased dosage of alcohol dehydrogenase 1.
Reverter-Branchat, Microbiology (Reading, England) 2007 (PubMed)- GeneRIF: A yeast strain with an extra copy of the ADH1 gene (2xADH1) demonstrated increased survival in stationary phase and a 30% extension in replicative life span.
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- Functionality and translation fidelity characterization of mRNA vaccines using platform based mass spectrometry detection
Stiving, NPJ vaccines 2025 (no snippet) - Utilizing deep ocean water in yeast fermentation for enhanced mineral-rich biomass production and fermentative regulation by proteomics modulation
Liu, Heliyon 2024 - “...32 3397 35.7 6.96 8 P00359 Glyceraldehyde-3-phosphate dehydrogenase 3 37.7 27 1479 35.7 6.96 9 P00330 Alcohol dehydrogenase 1 67.9 34 3514 36.8 6.68 10 P00925 Enolase 2 26.5 14 1234 46.9 6 11 P32324 Elongation factor 2 22.7 3 532 93.2 6.32 12 P00359 Glyceraldehyde-3-phosphate...”
- “...21 1251 35.7 8.28 16 P00359 Glyceraldehyde-3-phosphate dehydrogenase 3 63.0 30 862 35.7 6.96 17 P00330 Alcohol dehydrogenase 1 65.8 21 953 36.8 6.68 18 P00925 Enolase 2 35.1 40 2246 46.9 6 19 P00330 Alcohol dehydrogenase 1 63.2 20 886 36.8 6.68 20 P00924 Enolase...”
- Proteomic Identification and Quantification of Basal Endogenous Proteins in the Ileal Digesta of Growing Pigs
Ávila-Arres, Animals : an open access journal from MDPI 2024 - “...L from a stock of alcohol dehydrogenase 1 (ADH1) from Saccharomyces cerevisiae (Uniprot, accession number P00330; 1 pmol/L) was added as an internal standard to each sample to obtain a final concentration of 25 fmol/L (final volume of 100 L). Finally, samples were stored at 20...”
- 8-OxoG-Dependent Regulation of Global Protein Responses Leads to Mutagenesis and Stress Survival in Bacillus subtilis
Martínez, Antioxidants (Basel, Switzerland) 2024 - “...stock solution of alcohol dehydrogenase (ADH1, Waters, Milford, MA, USA) of Saccharomyces cerevisiae (UniProt accession: P00330), predigested with trypsin, was added as an internal standard to all peptide samples to obtain a final concentration of 25 fmolL 1 , as previously reported [ 39 ]. The...”
- Proteomic Profiling of COVID-19 Patients Sera: Differential Expression with Varying Disease Stage and Potential Biomarkers.
Dandachi, Diagnostics (Basel, Switzerland) 2024 - “...overnight digestion at 37 C. All the samples were spiked with yeast alcohol dehydrogenase (ADH; P00330) as an internal standard for absolute quantitation. Equal amounts of digested peptides and 3 g of each sample cohort was injected for the LCMS/MS analysis using one-dimensional Nano Acquity liquid...”
- “...Furthermore, we performed Hi3 absolute quantification using a known protein as the internal standard (ADH, P00330) for the absolute amount of each identified protein. The identified proteins were further filtered and limited to only those with confidence identifications with 2-identified peptides, with significantly altered proteins (...”
- An engineered baculoviral protein and DNA co-delivery system for CRISPR-based mammalian genome editing.
Capin, Nucleic acids research 2024 - “...Waters, Milford, MA, USA) containing 4 digested proteins (BSA P02769, PYGM P00489, ENO P00924, ADH P00330) was spiked in each sample, at a quantity of 150 fmol of ADH digest per injection. 9 l per sample, corresponding to 1 g of digested proteins, were analyzed by...”
- Quantitative proteomic analysis of residual host cell protein retention across adeno-associated virus affinity chromatography.
Leibiger, Molecular therapy. Methods & clinical development 2024 - “...-5, -8, and -9 (YP_680426.1, Q9YIJ1, YP_077180.1, and Q6JC40), Rep78 protein (YP_680423.1), EGFP (C5MKY7), ADH (P00330), and modified trypsin (AC_000). The remaining cellular proteins were normalized by dividing the average calculated relative abundance across triplicate injections for each individual HCP by the total average relative abundance...”
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W7MPI9 alcohol dehydrogenase from Gibberella moniliformis (strain M3125 / FGSC 7600)
41% identity, 96% coverage
- ITRAQ-based quantitative proteomic analysis of Fusarium moniliforme (Fusarium verticillioides) in response to Phloridzin inducers.
Zhang, Proteome science 2021 - “...4 up-regulated. Moreover, it was found that the differentially expressed proteins W7N5X1, W7MA30, W7M3M6, and W7MPI9, which collectively show significantly up-regulation, participate in 19 metabolic pathways in total, and the differentially expressed differentially-formed proteins W7LNK6, W7M651, participate in 13 metabolic pathways. Fig. 5 KEGG pathway enriched...”
5envA / P00330 Yeast alcohol dehydrogenase with bound coenzyme (see paper)
42% identity, 98% coverage
- Ligands: zinc ion; nicotinamide-adenine-dinucleotide; trifluoroethanol (5envA)
IVR12_00790 alcohol dehydrogenase AdhP from Limosilactobacillus reuteri
43% identity, 98% coverage
Q03RM0 Alcohol dehydrogenase from Levilactobacillus brevis (strain ATCC 367 / BCRC 12310 / CIP 105137 / JCM 1170 / LMG 11437 / NCIMB 947 / NCTC 947)
42% identity, 98% coverage
An17g01530 alcohol-dehydrogenase adhA from patent WO8704464-A-Aspergillus niger from Aspergillus niger
44% identity, 98% coverage
- Cytosolic streaming in vegetative mycelium and aerial structures of Aspergillus niger
Bleichrodt, Studies in mycology 2013 - “...An14g05350), RB7 and RB8 for flavohemoprotein ( flaA ; An14g02460), RB9 and RB10 for adhA (An17g01530), RB11 and RB12 for FAD binding oxidoreductase ( oxiA ; An18g00510), RB13 and RB14 for glaA (An03g06550) and RB15 and RB16 for 18S rDNA ( Table 2 ). The fragments...”
- “...Acbp - Saccharomyces carlsbergensis An09g05870 1120 Strong similarity to nucleoside-diphosphate kinase NDK-1 - Neurospora crassa An17g01530 1092 Alcohol-dehydrogenase adhA from patent WO8704464-A - Aspergillus niger An15g00070 1076 Strong similarity to malate dehydrogenase precursor MDH - Mus musculus An04g01430 1069 Weak similarity to hypothetical protein encoded by...”
- Trancriptional landscape of Aspergillus niger at breaking of conidial dormancy revealed by RNA-sequencing
Novodvorska, BMC genomics 2013 - “...123.91 An12g09950 alcohol dehydrogenase 118.28 92.97 0.62 149.95 An04g02690 alcohol dehydrogenase 35.46 163.73 21.91 7.47 An17g01530 adhA , alcohol dehydrogenase 21.35 71.04 5.21 13.63 An09g03140 alcohol dehydrogenase 11.59 132.35 3.76 35.19 An16g05420 glucose-6-phosphate isomerase 11.61 23.29 2.44 9.54 An02g14380 hxkA , hexokinase 6.26 24.59 5.16 4.76...”
K9H784 alcohol dehydrogenase from Penicillium digitatum (strain Pd1 / CECT 20795)
43% identity, 98% coverage
A5VLL8 Alcohol dehydrogenase from Limosilactobacillus reuteri (strain DSM 20016)
Lreu_1496 alcohol dehydrogenase from Lactobacillus reuteri DSM 20016
Lreu_1496 alcohol dehydrogenase AdhP from Limosilactobacillus reuteri subsp. reuteri
43% identity, 98% coverage
- Redox Balance in Lactobacillus reuteri DSM20016: Roles of Iron-Dependent Alcohol Dehydrogenases in Glucose/ Glycerol Metabolism
Chen, PloS one 2016 - “...- - - 8 A5VLQ6 Alcohol dehydrogenase (ADH4) lreu_1535 348 37899 - - - 8 A5VLL8 Alcohol dehydrogenase (ADH5) lreu_1496 342 36124 -0.87 -2.22 -2.95 8 A5VIB7 Alcohol dehydrogenase (ADH6) lreu_0321 878 97189 -2.01 -6.18 -7.18 8 A5VHI2 Alcohol dehydrogenase (ADH7) lreu_0030 390 42181 1.43 1.52...”
- “...S1 Fig Amino acid alignment of ADH1 (A5VMM4), ADH2 (A5VM35), ADH3 (A5VLU6), ADH4 (A5VLQ6), ADH5 (A5VLL8) and ADH8 (A5VLV6) from L . reuteri DSM20016. Red circle, putative catalytic residues; green circle, putative coenzyme binding motif; blue circle, the residues for the coordination of structural zinc. Strictly...”
- Global Analysis of Mannitol 2-Dehydrogenase in Lactobacillus reuteri CRL 1101 during Mannitol Production through Enzymatic, Genetic and Proteomic Approaches
Ortiz, PloS one 2017 - “...36284 6 Lreu_1860 Mannitol dehydrogenase [ Lactobacillus reuteri ATCC 53608] 22 gi|489764864 54 36615 5 Lreu_1496 Zinc-dependent alcohol dehydrogenase [ Lactobacillus reuteri ] 23 gi|148531697 52 14243 1 Lreu_1450 SSU ribosomal protein S9P [ Lactobacillus reuteri DSM 20016] 24 gi|194454156 49 37028 1 LRI_0357 D-lactate dehydrogenase...”
- Redox Balance in Lactobacillus reuteri DSM20016: Roles of Iron-Dependent Alcohol Dehydrogenases in Glucose/ Glycerol Metabolism
Chen, PloS one 2016 - “...A5VLQ6 Alcohol dehydrogenase (ADH4) lreu_1535 348 37899 - - - 8 A5VLL8 Alcohol dehydrogenase (ADH5) lreu_1496 342 36124 -0.87 -2.22 -2.95 8 A5VIB7 Alcohol dehydrogenase (ADH6) lreu_0321 878 97189 -2.01 -6.18 -7.18 8 A5VHI2 Alcohol dehydrogenase (ADH7) lreu_0030 390 42181 1.43 1.52 1.69 8 A5VLV6 Alcohol...”
- Cyclopropane fatty acid synthase mutants of probiotic human-derived Lactobacillus reuteri are defective in TNF inhibition
Jones, Gut microbes 2011 - “...(Lreu_1094) 3.0 NT01LR1589 alcohol dehydrogenase, propanol-preferring (Lreu_1496) 2.5 glnA (NT01LR1234) glutamine synthetase, type I (Lreu_1202) 2.0 Energy...”
FGSG_02034 alcohol dehydrogenase 1 from Fusarium graminearum PH-1
41% identity, 77% coverage
- Fungal Innate Immunity Induced by Bacterial Microbe-Associated Molecular Patterns (MAMPs)
Ipcho, G3 (Bethesda, Md.) 2016 - “...energetic demand as mentioned above. However, LOS specifically induced an additional alcohol dehydrogenase 1 ( FGSG_02034 ) that peaks at 1 hr as compared to the other treatments ( Table S10 ; 02.16 fermentation). Since iron sequestration is a key element for both animal ( Cherayil...”
- “...supports the idea of increased energetics demand. LOS additionally induced an alcohol dehydrogenase 1 ( FGSG_02034 ) that peaked at 1 hr, yet transcripts of this gene only accumulated to very low levels in response to PGN. This also potentially explains the earlier increase in gene...”
Q8CQ56 Alcohol dehydrogenase from Staphylococcus epidermidis (strain ATCC 12228 / FDA PCI 1200)
44% identity, 98% coverage
SERP0257 alcohol dehydrogenase, zinc-containing from Staphylococcus epidermidis RP62A
Q5HRD6 Alcohol dehydrogenase from Staphylococcus epidermidis (strain ATCC 35984 / DSM 28319 / BCRC 17069 / CCUG 31568 / BM 3577 / RP62A)
44% identity, 98% coverage
- Skin-to-blood pH shift triggers metabolome and proteome global remodelling in Staphylococcus epidermidis
Gonçalves, Frontiers in microbiology 2022 - “...Pyruvate, phosphate dikinase SERP1129 ppdK Pyruvate, water dikinase SERP2169 Phosphoenolpyruvate carboxykinase SERP1353 pckA Alcohol dehydrogenase SERP0257 adh Acetate kinase SERP1275 ackA Pyruvate formate lyase activating enzyme SERP2365 pflA Formate acetyltransferase SERP2366 pflB Dihydrolipoyl dehydrogenase SERP2327 Dihydrolipoamide acetyltransferase SERP2324 Oxidative Phosphorylation Cytochrome aa3-600 menaquinol oxidase subunit ii...”
- Deciphering the Antibacterial Mode of Action of Alpha-Mangostin on Staphylococcus epidermidis RP62A Through an Integrated Transcriptomic and Proteomic Approach
Sivaranjani, Frontiers in microbiology 2019 - “...log FC P -value SERP1987 narG Respiratory nitrate reductase, alpha subunit 2.56 3.47 10 -23 SERP0257 adh Alcohol dehydrogenase, zinc-containing 1.95 2.12 10 -18 SERP2080 aldA Aldehyde dehydrogenase family protein 2.20 6.47 10 -18 SERP2142 ansP Amino acid permease family protein 2.70 3.98 10 -17 SERP1784...”
- Proteomic Analysis Reveals a Biofilm-Like Behavior of Planktonic Aggregates of Staphylococcus epidermidis Grown Under Environmental Pressure/Stress
Bottagisio, Frontiers in microbiology 2019 - “...Moreover, the overexpression of putative aldehyde dehydrogenase SERP1729 ( SERP1729 gene, Q5HMA0), alcohol dehydrogenase ( SERP0257 gene, Q8CQ56), and zinc-type alcohol dehydrogenase-like protein SERP1785 ( SERP1785 gene, Q5HM44) strongly support the previous finding of anaerobic bacterial growth, besides the initial aerobic culture condition. This reflects a...”
- A New Bioactive Compound From the Marine Sponge-Derived Streptomyces sp. SBT348 Inhibits Staphylococcal Growth and Biofilm Formation
Balasubramanian, Frontiers in microbiology 2018 - “...2 fold change p adj value Carbon metabolism glmU UDP- N -acetylglucosamine pyrophosphorylase -2.1757 3.88E-44 SERP0257 Alcohol dehydrogenase zinc-containing -2.9328 7.33E-24 fruK 1-phosphofructokinase -2.0069 7.77E-11 hprK HPr kinase/phosphatase -2.3083 3.43E-37 Pgk Phosphoglycerate kinase -2.0399 3.02E-17 tpiA Triosephosphate isomerase -2.2812 2.56E-15 Pgi Glucose-6-phosphate isomerase -3.4822 1.38E-49 pdhA...”
- Staphylococcus epidermidis SrrAB regulates bacterial growth and biofilm formation differently under oxic and microaerobic conditions
Wu, Journal of bacteriology 2015 - “...SERP0706 SERP0646 SERP0645 SERP0644 SERP0643 SERP2381 SERP0257 SERP2112 SERP2257 SERP2365 SERP2366 SERP2183 SERP1795 SERP1793 SERP1791 SERP1873 SERP1874...”
- “...nrdD (anaerobic ribonucleoside triphosphate reductase), serp0257 (alcohol dehydrogenase), serp2257 (acetoin reductase), serp2133 (D-lactate dehydrogenase), and...”
- Redox sensing by a Rex-family repressor is involved in the regulation of anaerobic gene expression in Staphylococcus aureus
Pagels, Molecular microbiology 2010 - “...and S. epidermidis . Furthermore, adh1, although highly conserved in S. aureus and S. epidermidis (SERP0257), is only preceded by a Rex binding site in S. aureus . Moreover, dissimilatory nitrate and nitrite reductase activity, nitric oxide dioxygenase Hmp and the arc operon may be subjected...”
- Proteomic Analysis Reveals a Biofilm-Like Behavior of Planktonic Aggregates of Staphylococcus epidermidis Grown Under Environmental Pressure/Stress
Bottagisio, Frontiers in microbiology 2019 - “...70 6/65 (0.0102) (0.0013) LUXS_STAEQ Q5HM88 S-ribosylhomocysteine lyase 17.64/17.08 32 86 6/41 (0.0010) (0.0091) ADH_STAEQ Q5HRD6 Alcohol dehydrogenase 36.45/36.83 49 86 15/67 (HDMS E ) (0.0088) LDH_STAEQ Q5HL31 L-lactate dehydrogenase 34.10/34.14 33 68 10/48 (HDMS E ) (0.0053) IDH_STAEQ Q5HNL1 Isocitrate dehydrogenase 46.62/46.64 37 120 16/74...”
BAS2111 alcohol dehydrogenase, zinc-containing from Bacillus anthracis str. Sterne
BA2267 alcohol dehydrogenase, zinc-containing from Bacillus anthracis str. Ames
42% identity, 97% coverage
- Ser/Thr protein kinase PrkC-mediated regulation of GroEL is critical for biofilm formation in Bacillus anthracis
Arora, NPJ biofilms and microbiomes 2017 - “...Bas3348 113 54.5% 1-Pyrroline-5-carboxylate dehydrogenase Bas0295 197 52.0% Formate acetyltransferase Bas0481 94 42.3% Alcohol dehydrogenase Bas2111 144 59.7% Table 3 Phospho-enriched proteins in Bas -wt identified by mass spectrometry Protein identified Gene ID MS score Sequence coverage Leucine dehydrogenase Bas4070 151 32% GroEL, 60kDa chaperone Bas0253...”
- Changes in Bacillus anthracis CodY regulation under host-specific environmental factor deprived conditions
Kim, BMC genomics 2016 - “...(Fig. 1 ). Few differentially expressed genes were redundantly identified in two [ e.g. , BAS2111 (34F2 -Fe and 34F2 -Bic ), BAS4985 (34F2 -Fe and 34F2 -Glu ) or BAS5333 (34F2 -Bic and 34F2 -Glu )] or all of the conditions ( e.g. , BAS0253,...”
- “...13, and 16) were predicted to be involved in glycolysis and fermentation ( e.g. , BAS2111, BAS4492, BAS4869, BAS4986, BAS4987, and BAS4989) (Fig. 4(c) ). This observation suggests that transition from aerobic to anaerobic respiration is indirectly mediated by CodY, at least in terms of glycolysis...”
- Role of luxS in Bacillus anthracis growth and virulence factor expression
Jones, Virulence 2010 - “...large subunit (nirB) -1.33 -76.11 -60.97 -210.84 BA2267 alcohol dehydrogenase, zinc-containing -3.61 -12.91 -6.45 -9.19 BA2295 acetate CoA-transferase, subunit...”
AFUA_7G01010, Afu7g01010 alcohol dehydrogenase, putative from Aspergillus fumigatus Af293
44% identity, 97% coverage
- Disruption of the Aspergillus fumigatus RNA interference machinery alters the conidial transcriptome
Kelani, RNA (New York, N.Y.) 2023 - “...Data Set S4 ). At 48 h, we observed a high abundance of alcohol dehydrogenase (AFUA_7G01010), the same Cu/Zn superoxide dismutase (SodC) as in conidia, and several ubiquitin isoforms (AFUA_1G04040 and AFUA_3G11260); results that are consistent with the metabolic changes associated with carbon and iron starvation...”
- Distinct transcriptional responses to fludioxonil in Aspergillus fumigatus and its ΔtcsC and Δskn7 mutants reveal a crucial role for Skn7 in the cell wall reorganizations triggered by this antifungal
Schruefer, BMC genomics 2023 - “...down-regulated at both time points (Additional Table 3 ). The two neighbouring genes Afu7g01000 and Afu7g01010 encode a putative alcohol and a putative acetaldehyde dehydrogenase and are both strongly up-regulated at both time points (Fig. 6 A). The two flanking genes Afu7g0990 and Afu7g01020 that encode...”
- “...is indicated as log 2 -fc.mrn values. The deletion mutant of the putative alcohol dehydrogenase Afu7g01010 showed a normal growth on AMM ( B ), a severe growth defect on AMM containing 25mM ethanol as sole carbon source ( C ) and was as sensitive to...”
- Disruption of theAspergillus fumigatusRNA interference machinery alters the conidial transcriptome
Kelani, 2022 - The monothiol glutaredoxin GrxD is essential for sensing iron starvation in Aspergillus fumigatus
Misslinger, PLoS genetics 2019 - “...Ifa38 CNAG_04488 Afu2g11180 FlbA Developmental regulator 0.13 4.16 3.02 0.54 4.07 4.63 Sst2 Rgs1 CNAG_00125 Afu7g01010 Adh1 Alcohol dehydrogenase -1,73 0.41 4.57 - -2.72 -2.27 nd Adh1 nd We identified HapX as one of the most highly enriched proteins by GrxD Venus GFP-Trap under iron limitation...”
- Investigation of Aspergillus fumigatus biofilm formation by various "omics" approaches
Muszkieta, Frontiers in microbiology 2013 - “...22 AFUA_6G05210 27 Malate dehydrogenase, NAD-dependent 2.12 23 AFUA_6G07430 7 Pyruvate kinase 0.45 0.43 24 AFUA_7G01010 19 Alcohol dehydrogenase 0.47 83.45 25 AFUA_8G03930 3 Hsp70 chaperone (HscA) 0.46 0.46 4 0.49 5 0.45 a Spot number in Figure 4 . b Average ratios compared under biofilm...”
- Multiplexed activity-based protein profiling of the human pathogen Aspergillus fumigatus reveals large functional changes upon exposure to human serum
Wiedner, The Journal of biological chemistry 2012 - “...AFUA_5G07780 AFUA_5G04230 AFUA_4G13720 AFUA_5G08270 AFUA_7G01010 AFUA_6G10260 AFUA_1G15960 AFUA_2G10170 AFUA_8G00430 AFUA_4G09220 AFUA_3G12910 AFUA_2G17550...”
- “...15-fold change was observed in the alcohol dehydrogenase (AFUA_7G01010, EC 1.1.1.1) reactivity over time in HS culture (supplemental Table S4A). The alcohol...”
- Conservation of nucleosome positions in duplicated and orthologous gene pairs
Nishida, TheScientificWorldJournal 2012 - “...AFUA_2G15220 0.174259735 YER004W AFUA_6G08930 0.179730339 YDR365C AFUA_2G05420 0.181946191 YDR529C AFUA_4G06790 0.185927497 YDR062W AFUA_6G00300 0.189190157 YOL086C AFUA_7G01010 0.190813468 YOL026C AFUA_5G03630 0.19138562 YIL033C AFUA_3G10000 0.195925157 YBR290W AFUA_4G13740 0.19955841 YAR019C AFUA_4G06750 0.204744755 YHL007C AFUA_2G04680 0.20737573 YMR078C AFUA_7G05480 0.222707833 YDR311W AFUA_4G11690 0.22686955 YOL100W AFUA_3G12670 0.230714484 YGR162W AFUA_2G09490 0.232235851 YGL255W AFUA_1G01550...”
- Transcriptomic and proteomic analyses of the Aspergillus fumigatus hypoxia response using an oxygen-controlled fermenter
Barker, BMC genomics 2012 - “...response awaits further mechanistic characterization. In contrast to transcript levels, high protein levels of AlcA (Afu7g01010) suggest a critical role for this protein in the hypoxia response, as it was one of the highest induced proteins (Additional files 3 and 4 ). In A. nidulans ,...”
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AO090009000634 No description from Aspergillus oryzae RIB40
43% identity, 98% coverage
XP_451932 uncharacterized protein from Kluyveromyces lactis
42% identity, 91% coverage
ADH3 / P07246 alcohol dehydrogenase III (EC 1.1.1.1; EC 1.1.1.190) from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (see 10 papers)
ADH3_YEAST / P07246 Alcohol dehydrogenase 3, mitochondrial; Alcohol dehydrogenase III; ADHIII; YADH-3; EC 1.1.1.1 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see 8 papers)
NP_013800 alcohol dehydrogenase ADH3 from Saccharomyces cerevisiae S288C
YMR083W Adh3p from Saccharomyces cerevisiae
41% identity, 90% coverage
- function: Mitochondrial isozyme that reduces acetaldehyde to ethanol during the fermentation of glucose (Probable) (PubMed:22094012). Involved in the shuttling of mitochondrial reducing equivalents to the cytosol, where the redox balance is restored by NADH dehydrogenases on the external side of the mitochondrial inner membrane (PubMed:10940011). Shows a high affinity for alcohols with a double bond conjugated to the alcohol group (PubMed:1101965).
catalytic activity: a primary alcohol + NAD(+) = an aldehyde + NADH + H(+) (RHEA:10736)
catalytic activity: a secondary alcohol + NAD(+) = a ketone + NADH + H(+) (RHEA:10740)
catalytic activity: ethanol + NAD(+) = acetaldehyde + NADH + H(+) (RHEA:25290)
catalytic activity: butan-1-ol + NAD(+) = butanal + NADH + H(+) (RHEA:33199)
catalytic activity: hexan-1-ol + NAD(+) = hexanal + NADH + H(+) (RHEA:60972)
cofactor: Zn(2+) (Binds 2 Zn(2+) ions per subunit.)
subunit: Homotetramer. - The proteome response to amyloid protein expression in vivo
Gomes, PloS one 2012 - “...P00330 994 704 563 9 ADH3 Alcohol dehydrogenase 3, mitochondrial +1.4 1.23E-02 +1.5 2.75E-03 CM P07246 950 977 774 10 ADK Adenosine kinase +1.4 3.62E-03 NM P47143 1094 537 429 4 AIM29 Altered inheritance rate of mitochondria protein 29 1.4 8.26E-03 1.4 1.29E-02 U P36154 1453...”
- Changes in disulfide bond content of proteins in a yeast strain lacking major sources of NADPH
Minard, Free radical biology & medicine 2007 - “...P00330 36,849 6.66 8 Adh3p Mitochondrial alcohol dehydrogenase P07246 40,369 8.52 2 Eno1p Enolase P00924 46,816 6.60 16 Eno2p Enolase P00925 46,914 5.88 6...”
- Purification and properties of methyl formate synthase, a mitochondrial alcohol dehydrogenase, participating in formaldehyde oxidation in methylotrophic yeasts
Murdanoto, Applied and environmental microbiology 1997 - “...(cytosolic), P00331; S. cerevisiae Adh3p (mitochondrial), P07246; Kluyveromyces lactis Adh1p (cytosolic), P20369; K. lactis Adh3p (mitochondrial), P49384;...”
- Repression of ADH1 and ADH3 during zinc deficiency by Zap1-induced intergenic RNA transcripts.
Bird, The EMBO journal 2006 - GeneRIF: During zinc deficiency, Zap1 mediates the repression of two of the most abundant zinc-requiring enzymes.
- Environmental systems biology of cold-tolerant phenotype in Saccharomyces species adapted to grow at different temperatures
Paget, Molecular ecology 2014 - “...acetaldehyde->ethanol YOL086c YGL256w YBR145w ADH1 ADH4 ADH5 Pyruvate metabolism 1.1.1.1 Alcohol dehydrogenase: reverse rxn: acetaldehyde->ethanol YMR083w ADH3 Pyruvate metabolism 1.1.1.1 Alcohol dehydrogenase: ethanol YDL168w SFA1 Pyruvate metabolism 1.1.1.1 Adenosine monophosphate deaminase YML035c AMD1 Purine and pyrimidine biosynthesis Biotin acetyl-CoA carboxylase ligase YDL141w BPL1 Pantothenate and CoA...”
- “...the three media types at 16 C were GUT2 ( YIL155c ) and ADH3 ( YMR083w ). Both genes have orthologs in S. kudriavzevii , and we expected that mutation in any of them would have a larger deleterious effect in this cold-tolerant species compared with...”
- Adjustment of trehalose metabolism in wine Saccharomyces cerevisiae strains to modify ethanol yields
Rossouw, Applied and environmental microbiology 2013 - “...ADH5 ALD6 ALD4/ALD3 ALD5/ALD2/ALD3 ALD7 YOL086c YMR303c YMR083w YGL256w YBR145w YPL061w YMR169c YMR170c YOR374w Y16236 Y10891 Y16217 Y14623 Y13284 Y12767 Y10752...”
- Ontology-Based Querying with Bio2RDF's Linked Open Data
Callahan, Journal of biomedical semantics 2013 - “...GO function with label zinc ion binding Gene identifier Gene label Description Protein identifier http://bio2rdf.org/sgd:S000004688 YMR083W Mitochondrial alcohol dehydrogenase isozyme III http://bio2rdf.org/sgd:S000004688gp http://bio2rdf.org/sgd:S000000349 YBR145W Alcohol dehydrogenase isoenzyme V http://bio2rdf.org/sgd:S000000349gp http://bio2rdf.org/sgd:S000002624 YDR216W Carbon source-responsive zinc-finger transcription factor http://bio2rdf.org/sgd:S000002624gp http://bio2rdf.org/sgd:S000000819 YER017C Component of the mitochondrial inner membrane m-AAA...”
- Nutrient control of eukaryote cell growth: a systems biology study in yeast
Gutteridge, BMC biology 2010 - “...transcript log. fold changes in each nutrient-limiting condition relative to the overall mean for ADH3 (YMR083W). A random sample of fold changes from other genes is shown in grey for comparison. c) Protein and transcript log. fold changes for ADH1 (YOL086C). A high TCE for a...”
- “...post-transcriptional regulation acts in this condition. Three ORFs show a high TCE in sulphur-limitation: Adh3p (YMR083W), Rtc3p (YHR087W) and the transketolase Tkl2p (YBR117C). Again, for the first two, there are no large effects on transcript levels due to nutrient limitation, but protein abundance is more than...”
- Comparative transcriptomic and proteomic profiling of industrial wine yeast strains
Rossouw, Applied and environmental microbiology 2010 - “...EGD1 EGD2 YOR128C YGR204W YMR300C YGL234W YOL086C YMR083W YDR226W YPL061W YJR105W YKL157W YOL058W YHR018C YDR127W YGL148W YDR035W YBR249C YGL202W YPR145W...”
- Systems-level engineering of nonfermentative metabolism in yeast
Kennedy, Genetics 2009 - “...YBL013W YOL017W YHR001W-A YNL055C YKL016C YJR121W YER081W YMR083W YOL067C YOR100C YNL256W YNL037C YLR071C YOR136W YKL120W YLR442C YPL075W YLR033W YML091C...”
- Upstream sequence elements direct post-transcriptional regulation of gene expression under stress conditions in yeast
Lawless, BMC genomics 2009 - “...to draw any general conclusions. However, one notable gene is the mitochondrial alcohol dehydrogenase ADH3 (YMR083W) which has a highly conserved uORF at position -281 with respect to the start codon, and is down regulated in low peroxide concentrations. Conclusion In this study we have examined...”
- Repression of sulfate assimilation is an adaptive response of yeast to the oxidative stress of zinc deficiency
Wu, The Journal of biological chemistry 2009 - “...2017 b Function Exp. A Zinc homeostasis YOL086C YMR083W YMR303C Others YBR158W YDR177W YEL040W YGL089C YIL118W YIL158W YKL029C YKL178C YML040W YMR051C YNL051W...”
- More
XP_500127 YALI0A16379p from Yarrowia lipolytica CLIB122
43% identity, 97% coverage
Q9CEN0 alcohol dehydrogenase (EC 1.1.1.1) from Lactococcus lactis subsp. lactis (see paper)
NP_267964 alcohol dehydrogenase (EC 1.1.1.1) from Lactococcus lactis subsp. lactis Il1403
41% identity, 98% coverage
XP_503282 YALI0D25630p from Yarrowia lipolytica CLIB122
43% identity, 97% coverage
A1IIA3 alcohol dehydrogenase (EC 1.1.1.1) from Kluyveromyces marxianus (see paper)
42% identity, 91% coverage
V9SCJ1 alcohol dehydrogenase (EC 1.1.1.1) from Kluyveromyces marxianus (see paper)
42% identity, 91% coverage
KLMA_80306 alcohol dehydrogenase 3 from Kluyveromyces marxianus DMKU3-1042
42% identity, 97% coverage
- CRISPR-Cas9-enabled genetic disruptions for understanding ethanol and ethyl acetate biosynthesis in Kluyveromyces marxianus
Löbs, Biotechnology for biofuels 2017 - “...of interest were identified in the annotated genome of K. marxianus DMKU3-1042 as KLMA_40102, KLMA_40220, KLMA_80306, KLMA_20158, KLMA_20005 KLMA_80339, and KLMA_40624 for Km ADH17, respectively and KLMA_30203 for Km ATF [ 19 ]. Blast searches confirmed the presences of each gene in the unannotated genome of...”
- Genetic basis of the highly efficient yeast Kluyveromyces marxianus: complete genome sequence and transcriptome analyses
Lertwattanasakul, Biotechnology for biofuels 2015 - “...Inulinase INU1 Sucrose, raffinose, inulin KLMA_40102 Alcohol dehydrogenase 1 ADH1 KLMA_40220 Alcohol dehydrogenase 2 ADH2 KLMA_80306 Alcohol dehydrogenase 3 ADH3 KLMA_20005 Alcohol dehydrogenase 4a ADH4a KLMA_20158 Alcohol dehydrogenase 4b ADH4b KLMA_40624 Alcohol dehydrogenase ADH KLMA_80339 Alcohol dehydrogenase 6 ADH6 NAD, nicotinamide adenine dinucleotide; NADP, nicotinamide adenine...”
4eezB Crystal structure of lactococcus lactis alcohol dehydrogenase variant re1 (see paper)
41% identity, 98% coverage
LLKF_1981 alcohol dehydrogenase 1 from Lactococcus lactis subsp. lactis KF147
41% identity, 98% coverage
BC2220 Alcohol dehydrogenase from Bacillus cereus ATCC 14579
Q81DX6 Alcohol dehydrogenase from Bacillus cereus (strain ATCC 14579 / DSM 31 / CCUG 7414 / JCM 2152 / NBRC 15305 / NCIMB 9373 / NCTC 2599 / NRRL B-3711)
BC_2220 alcohol dehydrogenase AdhP from Bacillus cereus ATCC 14579
41% identity, 97% coverage
- SecDF as part of the Sec-translocase facilitates efficient secretion of Bacillus cereus toxins and cell wall-associated proteins
Vörös, PloS one 2014 - “...in oxidative phosphorylation (operons BC3941-3944; BC0695-0698) including a cytochrome d ubiquinol oxidase (BC4792-4793), fermentation (BC0491-0492, BC2220), anaerobic respiration (BC2134, BC2128) and the regulator of the arginine deaminase operon arcABDC (BC0410). The genome of B. cereus ATCC 14579 also contains a cryptic, linear plasmid pBClin15, encoding what...”
- Linking genome content to biofuel production yields: a meta-analysis of major catabolic pathways among select H2 and ethanol-producing bacteria
Carere, BMC microbiology 2012 - “...Geoth_2349 Geoth_3494 Geoth_0631 B. cereus ATCC 14579 BC5387 BC4637 BC2832 BC0802 BC4365 BC3555 BC2529 BC1285 BC2220 Abbreviations: pta , phosphotransacetylase; ack , acetate kinase; atk , acetate thiokinase; aldH , acetaldehyde dehydrogenase; adh , alcohol dehydrogenase; adhE ; bifunctional acetylaldehyde/alcohol dehydrogenase. Alternatively, acetyl-CoA may be converted...”
- Global gene expression profile for swarming Bacillus cereus bacteria
Salvetti, Applied and environmental microbiology 2011 - “...BC4792 BC0406 BC0407 BC0408 BC0409 BC0410 BC0491 BC0492 BC2220 BC0668 BC2134 BC2128 Virulence Other a BC3526 BC3698 BC3101 BC0753 BC0754 BC0755 BC0756 BC1435...”
- “...forms of fermentation (BC0491, BC0492, and BC2220), oxidative phosphorylation (BC4792), and anaerobic respiration (BC2128 and BC2134), were downregulated...”
- Redox proteomic study of Bacillus cereus thiol proteome during fermentative anaerobic growth
Hamitouche, BMC genomics 2021 - “...and phosphoenolpyruvate PtsI (Q819D7), the fermentative enzyme pyruvate formate-lyase PflA (Q81IA2), and alcohol dehydrogenase (AdhA, Q81DX6), which also plays an important role in fermentative metabolism. Three distinct modified cysteines were identified in AdhA: Cys 255 was mainly detected as RedCys at MEP, whereas the two others...”
- “...resistance protein NS NS Function unknown Q81IG4 65 Thiamine_BP domain-containing protein NS NS Carbohydrate metabolism Q81DX6 97 AdhA Alcohol dehydrogenase NS NS Cys proteins in MEP Nucleotide metabolism Q81J22 153 Adk Adenylate kinase NS NS Q81IS3 250 GuaA GMP synthase NS NS Q81IQ3 527 PurL Phosphoribosyl...”
- Proteomic evidences for rex regulation of metabolism in toxin-producing Bacillus cereus ATCC 14579
Laouami, PloS one 2014 - “...such L-lactate dehydrogenases (Ldh; BC_1924, BC_4870, BC_4996), pyruvate formate lyase (PflB; BC_0491), alcohol dehydrogenase (BC_4365, BC_2220, BC_0802) and acetate kinase (BC_4634) were not significantly different in the mutant compared with wild-type cells. However, the lack of Rex resulted in a decrease of the abundance of the...”
A6T9L3 alcohol dehydrogenase from Klebsiella pneumoniae subsp. pneumoniae (strain ATCC 700721 / MGH 78578)
KP1_2916 alcohol dehydrogenase from Klebsiella pneumoniae NTUH-K2044
47% identity, 98% coverage
ADH_SCHPO / P00332 Alcohol dehydrogenase; EC 1.1.1.1 from Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) (see 2 papers)
SPCC13B11.01 alcohol dehydrogenase Adh1 from Schizosaccharomyces pombe
NP_588244 alcohol dehydrogenase Adh1 from Schizosaccharomyces pombe
44% identity, 98% coverage
5yatA / C4R0S8 Crystal structure of mitochondrial alcohol dehydrogenase isozyme iii from komagataella phaffii gs115 (see paper)
44% identity, 98% coverage
CNAG_07745 alcohol dehydrogenase, propanol-preferring from Cryptococcus neoformans var. grubii H99
44% identity, 81% coverage
- A PAS Protein Directs Metabolic Reprogramming during Cryptococcal Adaptation to Hypoxia
Zhao, mBio 2021 - “...involved in glycolysis ( CNAG_05387 and CNAG_06290 ), fermentation ( CNAG_01955 , CNAG_04659 , and CNAG_07745 ), gluconeogenesis ( CNAG_04217 ), the PPP ( CNAG_04025 and CNAG_06923 ), and the TCA cycle ( CNAG_06374 ) were highly induced in response to hypoxia in the wild type...”
- A Fungal Arrestin Protein Contributes to Cell Cycle Progression and Pathogenesis
Telzrow, mBio 2019 - “...4.0 0.0 CNAG_02673 NAD-dependent epimerase/dehydratase 3.7 0.0 CNAG_02811 Small subunit ribosomal protein S29 3.7 0.0 CNAG_07745 MPD1 Alcohol dehydrogenase, propanol preferring 3.3 0.0 CNAG_00176 Glutamate carboxypeptidase 3.3 0.0 CNAG_01404 Hsp71-like protein 3.3 0.0 CNAG_02500 Calnexin 3.0 0.0 CNAG_02991 Cofilin 3.0 0.0 CNAG_02943 Cytoplasmic protein 3.0 0.0...”
- Protection against Experimental Cryptococcosis following Vaccination with Glucan Particles Containing Cryptococcus Alkaline Extracts
Specht, mBio 2015 - “...0 CNAG_04443 Hypothetical protein 5 No 19,418 8E10 CNAG_04269 Leucyl aminopeptidase 5 Yes 15,297 0.62 CNAG_07745 Alcohol dehydrogenase, propanol-preferring 5 No 46,734 3E12 a The relative abundance of protein, averaged for two cap59 extracts. The most abundant protein, phosphatidylglycerol transfer protein, was arbitrarily set at 100....”
- Brain inositol is a novel stimulator for promoting Cryptococcus penetration of the blood-brain barrier
Liu, PLoS pathogens 2013 - “...CNAG_07660 Pyruvate dehydrogenase 3.51 CNA01050 CNAG_00115 Sorbitol dehydrogenase 3.33 CNJ00950 CNAG_04659 Pyruvate decarboxylase 3.23 CNG00600 CNAG_07745 Mannitol-1-phosphate dehydrogenase 3.00 CNC06440 CNAG_01539 Inositol-1-phosphate synthase (Ino1) 2.79 CNE01560 CNAG_02399 Glutathione reductase 2.72 CND00180 CNAG_00879 Glutamate dehydrogenase 2.63 CNA04610 CNAG_07363 Isocitrate dehydrogenase 2.59 CNL04840 CNAG_05138 Exo-beta-1,3-glucanase 2.54 CNC02410 CNAG_01737...”
- A defect in ATP-citrate lyase links acetyl-CoA production, virulence factor elaboration and virulence in Cryptococcus neoformans
Griffiths, Molecular microbiology 2012 - “...3 13 CNAG_01102 Glucose 1-dehydrogenase ATTCAAAAAA 1 13 CNAG_04640 ATP-citrate lyase, ACL1 ATAAGCTTTC 0 12 CNAG_07745 Mannitol-1-phosphate dehydrogenase GTCGTAGAGT 2 9 CNAG_03072 Enolase 3 TGTCAAAAAA 0 7 Transaldolase CCATATGTTT 0 4 CNAG_06666 Glycogen phosphorylase-like protein CATTTCTTCA 0 4 CNAG_02552 Transketolase Lipid Metabolism CATTTATGAA 1 11 CNAG_03936...”
ADH2_YARLI / F2Z678 Alcohol dehydrogenase 2; EC 1.1.1.1 from Yarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica)
XP_504077 YALI0E17787p from Yarrowia lipolytica CLIB122
43% identity, 97% coverage
- function: Versatile oxidoreductase that catalyzes the oxidation and reduction of a broad range of substrates. Preferentially oxidizes secondary alcohols. Has highest activity for racemic 2-octanol. Is also an efficient reductase for selected substrates. Substrate selectivity was found for medium chain lipophilic ketones. Has highest activities for 2-octanone, 2-nonanone and 2-decanone. The enzyme is (S)-selective in the reduction direction and produces exclusively the (S)-enantiomer.
catalytic activity: a secondary alcohol + NAD(+) = a ketone + NADH + H(+) (RHEA:10740)
cofactor: Zn(2+) (Binds 2 Zn(2+) ions per subunit.)
subunit: Homotetramer. - Enantiocomplementary Yarrowia lipolytica Oxidoreductases: Alcohol Dehydrogenase 2 and Short Chain Dehydrogenase/Reductase
Napora-Wijata, Biomolecules 2013 - “...ADH1 Yl ADH1 Yl ADH2 Yl ADH3 Yl ADH Yl ADH Acc. Nr.: NP_014555 XP_503282 XP_504077 XP_500127 XP_500087 XP_503672 NP_014555 100 68 68 69 66 54 XP_503282 80 100 94 98 81 57 XP_504077 82 98 100 94 79 56 XP_500127 80 99 97 100 82...”
- Validated Growth Rate-Dependent Regulation of Lipid Metabolism in Yarrowia lipolytica
Poorinmohammad, International journal of molecular sciences 2022 - “...as acceptor [GO:0016616] Up 2.48 8.64 Q6CAP1 - carbohydrate:proton symporter activity [GO:0005351] Up 3.66 7.88 F2Z678 Alcohol dehydrogenase 2 alcohol dehydrogenase (NAD+) activity [GO:0004022]; zinc ion binding [GO:0008270] Up 1.81 8.42 Q6CI12 - hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines [GO:0016813];...”
STM1567 alcohol dehydrogenase, propanol preferring from Salmonella typhimurium LT2
46% identity, 98% coverage
- Mass spectrometry-based quantitative proteomic analysis of Salmonella enterica serovar Enteritidis protein expression upon exposure to hydrogen peroxide
Kim, BMC microbiology 2010 - “...31% STM1431 Superoxide dismutase sodB 21.35 5.58 35% STM1544 PhoPQ-regulated protein pqaA 59.27 6.87 20% STM1567 Alcohol dehydrogenase adhP 35.49 5.8 42% STM1589 Putative NADP-dependent oxidoreductase yncB 39.2 5.6 23% STM1641 ATP-dependent helicase hrpA 148.71 8.22 15% STM1661 Putative universal stress protein ydaA 35.62 5.17 66%...”
- “...pykF 87 12% STM1431 Superoxide dismutase sodB 110 20% STM1544 PhoPQ-regulated protein pqaA 19 2% STM1567 Alcohol dehydrogenase adhP 9 2% STM1589 Putative NADP-dependent oxidoreductase yncB 12 2% STM1641 ATP-dependent helicase hrpA 20 3% STM1661 Putative universal stress protein ydaA 140 20% STM1682 Probable peroxidase tpx...”
ADH1_EMENI / P08843 Alcohol dehydrogenase 1; Alcohol dehydrogenase I; ADH I; EC 1.1.1.1 from Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans) (see paper)
alcA alcohol dehydrogenase 1; EC 1.1.1.1 from Emericella nidulans (see 3 papers)
ANIA_08979 alcohol dehydrogenase alcA from Aspergillus nidulans FGSC A4
43% identity, 98% coverage
- catalytic activity: a primary alcohol + NAD(+) = an aldehyde + NADH + H(+) (RHEA:10736)
catalytic activity: a secondary alcohol + NAD(+) = a ketone + NADH + H(+) (RHEA:10740)
cofactor: Zn(2+) (Binds 2 Zn(2+) ions per subunit.)
subunit: Homotetramer - CharProtDB Description: Alcohol dehydrogenase with a role in two-carbon compound metabolism; expression is negatively regulated by glucose; Source:AspGD
- Specialisation events of fungal metacommunities exposed to a persistent organic pollutant are suggestive of augmented pathogenic potential
Martins, Microbiome 2018 - “...S5). The levels of aldehyde and alcohol dehydrogenases greatly increased upon PCP exposure (P41751 and P08843, log 2 FC = 8.5 and 7.42). These enzymes have been previously linked to the degradation of many aromatic hydrocarbons, e.g., naphthalene [ 16 ]. The involvement of these enzymes...”
- Modular Synthetic Biology Toolkit for Filamentous Fungi
Mózsik, ACS synthetic biology 2021 - “...TetO UAS + CPgpdA (fused) pICH41295 pVG2.2 ( 5 ) pFTK020 171292 P1 PalcA synt_NoCrea (ANIA_08979) promoter pICH41295 A nidulans FGSC A4 ( 39 ) pFTK021 171293 P1 Pu3 hom., Putp25, P. rubens Pol-III promoter pICH41295 P. rubens DS54468 ( 28 ) pFTK022 171294 P1 Pu6...”
Pc21g22820 uncharacterized protein from Penicillium rubens
43% identity, 98% coverage
P43067 Alcohol dehydrogenase 1 from Candida albicans
44% identity, 97% coverage
- The Identification and Characterization of Immunoreactive Fungal Proteins Recognized by Sera from Zimbabweans Sensitized to Fungi.
Pfavayi, International archives of allergy and immunology 2022 - “...XP_018385554.1 GroES-like protein ( Alternaria alternata ) 352 Cand a 1 Cand a 1 AAA53300 P43067 350 350 307.0 304.3 6.3e85 4.0e84 6 GFF50131.1 Dipeptidyl-peptidase 5 ( Aspergillus lentulus ) 721 Tri r 4.0101 AAD52012 726 666.6 1.5e192 7 XP_001260402.1 Secreted dipeptidyl peptidase ( Aspergillus fischeri...”
- Global proteomic analysis deciphers the mechanism of action of plant derived oleic acid against Candida albicans virulence and biofilm formation
Muthamil, Scientific reports 2020 - “...regulated proteins CAP1 4.2 0.002 P83773 Acetyl-CoA hydrolase 2.86E+11 19.7 20 ACH1 CAP3 3.2 0.006 P43067 Alcohol dehydrogenase 184 6.3 7 ADH1 CAP5 2.8 0.003 O94048 Porphobilinogen deaminase 1195 16.8 12 HEM3 CAP6 2.8 0.152 Q59T36 mRNA 3-end-processing protein 6.41E+06 30 15 YTH1 CAP8 2.6 0.003...”
- Adhesive protein-mediated cross-talk between Candida albicans and Porphyromonas gingivalis in dual species biofilm protects the anaerobic bacterium in unfavorable oxic environment
Bartnicka, Scientific reports 2019 - “...(Als2) 2.2 9.3 nd 14.8 Q59XX2 Cell surface mannoprotein MP65 (Mp65) 1.6 5.5 9.4 6.9 P43067 Alcohol dehydrogenase 1 (Adh1) 1.4 nd nd 5.9 Q5AFA2 Extracellular glycosidase (Crh11) 1.2 1.7 nd nd Q59L12 Agglutinin-like protein 3 (Als3) 1.1 7.0 nd nd Q59TP1 Cell wall protein RTB1...”
- The activity of bacterial peptidylarginine deiminase is important during formation of dual-species biofilm by periodontal pathogen Porphyromonas gingivalis and opportunistic fungus Candida albicans
Karkowska-Kuleta, Pathogens and disease 2018 - “...1 Heat shock protein Ssb1 pH-regulated antigen P43067 (ADH1 CANAX) P83779 (PDC1 CANAL) Q59XX2 (MP65 CANAL) Q5AIR7 (ENG1 CANAL) P87222 (HSP75...”
- Insight into different environmental niches adaptation and allergenicity from the Cladosporium sphaerospermum genome, a common human allergy-eliciting Dothideomycetes.
Yew, Scientific reports 2016 - “...shock protein Asp f 12 b P40292 UM843_1120 (85) Alcohol dehydrogenase Cand a 1 b P43067 UM843_1327 (61), UM843_9747 (62) Aldolase Cand a FPA Q9URB4 UM843_7727 (68) a For genes that have matches to two accession numbers, the percentage of identity showed matches to the first...”
- Physical Features of Intracellular Proteins that Moonlight on the Cell Surface
Amblee, PloS one 2015 - “...plasminogen binding Haemophilus influenzae P44324 [ 25 ] Alcohol dehydrogenase (ADH1) plasminogen binding Candida albicans P43067 [ 26 ] Bile salt hydrolase plasminogen binding Bifidobacterium lactis , B . bifidum , and B . longum Q9KK62 [ 27 ] Peroxisomal catalase (CTA1) plasminogen binidng Candida albicans...”
- Mold allergens in respiratory allergy: from structure to therapy
Twaroch, Allergy, asthma & immunology research 2015 - “...214 N-acetylglucosaminidase 72 + Q0PV90 Candida albicans Cand a 1 215,216 alcohol dehydrogenase 40 - P43067 Cand a 3 217 peroxisomal membrane protein 29 + Q6YK78 Cand a CAAP 218 acid protease 44 36.7 49 219 - Cand a CyP 80 rotamase, cyclophilin 18 + Cand...”
- Purification and properties of methyl formate synthase, a mitochondrial alcohol dehydrogenase, participating in formaldehyde oxidation in methylotrophic yeasts
Murdanoto, Applied and environmental microbiology 1997 - “...K. lactis Adh3p (mitochondrial), P49384; Candida albicans Adhp, P43067. 1718 MURDANOTO ET AL. APPL. ENVIRON. MICROBIOL. TABLE 3. Apparent kinetic parameters for...”
ATEG_09407 alcohol dehydrogenase I from Aspergillus terreus NIH2624
43% identity, 98% coverage
A0A1D8PP43 alcohol dehydrogenase (EC 1.1.1.1); 2-oxoaldehyde dehydrogenase (NAD+) (EC 1.2.1.23) from Candida albicans (see paper)
XP_721905 Adh1p from Candida albicans SC5314
44% identity, 97% coverage
- Alcohol dehydrogenase 1 and NAD(H)-linked methylglyoxal oxidoreductase reciprocally regulate glutathione-dependent enzyme activities in Candida albicans.
Kang, Journal of microbiology (Seoul, Korea) 2021 (PubMed)- GeneRIF: Alcohol dehydrogenase 1 and NAD(H)-linked methylglyoxal oxidoreductase reciprocally regulate glutathione-dependent enzyme activities in Candida albicans.
- ADH1 promotes Candida albicans pathogenicity by stimulating oxidative phosphorylation.
Song, International journal of medical microbiology : IJMM 2019 (PubMed)- GeneRIF: ADH1 deletion significantly increases CSH and reduces C. albicans virulence in terms of adhesion, hyphal formation and biofilm formation in accord with the downregulation of virulence-related genes such as ALS1, ALS3, HWP1, and CSH1
- Inducible NAD(H)-linked methylglyoxal oxidoreductase regulates cellular methylglyoxal and pyruvate through enhanced activities of alcohol dehydrogenase and methylglyoxal-oxidizing enzymes in glutathione-depleted Candida albicans.
Kwak, Biochimica et biophysica acta. General subjects 2018 (PubMed)- GeneRIF: Methylglyoxal-oxidizing NAD(H)-linked Mgd1/Grp2 was found solely in glutathione auxotrophs, and it catalyzed the reduction of both methylglyoxal and pyruvate. MGD1/GRP2 disruptants showed growth defects, cell-cycle arrest, and methylglyoxal and pyruvate accumulation with mitochondrial impairment, regardless of ADH1 compensation.
ADH1 alcohol dehydrogenase from Candida albicans (see 11 papers)
43% identity, 78% coverage
- CharProtDB CGD description: Alcohol dehydrogenase; at yeast-form but not hyphal cell surface; soluble in hyphae; immunogenic in human or mouse; complements S. cerevisiae adh1 adh2 adh3 mutation; regulated by growth phase, carbon source; fluconazole-, farnesol-induced
C0NQX6 alcohol dehydrogenase from Ajellomyces capsulatus (strain G186AR / H82 / ATCC MYA-2454 / RMSCC 2432)
HCBG_05406 alcohol dehydrogenase from Histoplasma capsulatum G186AR
42% identity, 96% coverage
C7A06_RS17240 alcohol dehydrogenase AdhP from Escherichia coli
47% identity, 91% coverage
PAAG_00403 alcohol dehydrogenase from Paracoccidioides lutzii Pb01
42% identity, 96% coverage
VDAG_07507 alcohol dehydrogenase from Verticillium dahliae VdLs.17
42% identity, 96% coverage
- Functional Role of RING Ubiquitin E3 Ligase VdBre1 and VdHrd1 in the Pathogenicity and Penetration Structure Formation of Verticillium dahliae
Yang, Journal of fungi (Basel, Switzerland) 2023 - “...Selected genes from the lipid metabolism pathway were validated using qPCR, displaying significant down-regulation of VDAG_07507 , VDAG_09868 , VDAG_02241 , and VDAG_07771 , whereas VDAG_05865 , VDAG_07080 , VDAG_00583 , VDAG_07881 , and VDAG_07695 were markedly up-regulated ( Figure 5 B,C). The genes examined in...”
- Hypothetical Protein VDAG_07742 Is Required for Verticillium dahliae Pathogenicity in Potato
Wang, International journal of molecular sciences 2023 - “...VDAG_06523 VDAG_06079 VDAG_02886 VDAG_08496 VDAG_09536 VDAG_08929 VDAG_05344 10.37 11.3 Map00350 Tyrosine metabolism VDAG_04798 VDAG_03345 VDAG_07316 VDAG_07507 VDAG_07314 VDAG_07369 VDAG_06372 7.04 4.49 Map00600 Sphingolipid metabolism VDAG_05015 VDAG_05347 VDAG_01556 VDAG_07821 10.23 3.41 Map00561 Glycerolipid metabolism VDAG_09648 VDAG_04951 VDAG_09741 VDAG_02013 VDAG_07738 7.04 3.31 Map00010 Glycolysis/Gluconeogenesis VDAG_07446 VDAG_07507 VDAG_09741 VDAG_02013...”
PP3839, PP_3839 alcohol dehydrogenase, zinc-containing from Pseudomonas putida KT2440
46% identity, 98% coverage
- Bioprocess exploitation of microaerobic auto-induction using the example of rhamnolipid biosynthesis in Pseudomonas putida KT2440
Grether, Journal of biological engineering 2025 - “...ccoN-1 (PP_4250) was amplified. For pJG- adhP::gfp , the 435bp upstream region of the adhP (PP_3839) gene was amplified. The 510bp upstream region of the gene rmf (PP_5502) was amplified for the construction of the biosensor plasmid pJG- rmf::gfp . For other purposes that are not...”
- Pseudomonas putida as a platform for medium-chain length α,ω-diol production: Opportunities and challenges
Lu, Microbial biotechnology 2024 - “...the presence of various alcohol dehydrogenases. By deleting pedF ( PP_2675 ) and adhP ( PP_3839 ) and coexpressing of Atf1, alkyl acetate was successfully detected. Coexpression of the fatty acid transporter ScTP further increased hexanol and hexyl acetate production in P.putida . Mono and diester...”
- Core and auxiliary functions of one-carbon metabolism in Pseudomonas putida exposed by a systems-level analysis of transcriptional and physiological responses
Turlin, mSystems 2023 - “...different putative or characterized alcohol dehydrogenase genes, the products which could potentially act on methanol. PP_3839 (AdhP), for instance, has been previously characterized to act on short-chain alcohols ( 86 ). In our experiments, the expression of adhP was slightly downregulated upon methanol treatmentperhaps as a...”
- Vanillin Production in Pseudomonas: Whole-Genome Sequencing of Pseudomonas sp. Strain 9.1 and Reannotation of Pseudomonas putida CalA as a Vanillin Reductase
García-Hidalgo, Applied and environmental microbiology 2020 - “...frames encode aldehyde reductases that convert vanillin to vanillyl alcohol, and that P. putida KT2440 PP_3839 encodes a coniferyl alcohol dehydrogenase that oxidizes coniferyl alcohol to coniferyl aldehyde (i.e., the function previously assigned to calA ). The deletion of PP_2426 in P. putida GN442 engineered to...”
- “...Based on these results, we propose the reannotation of PP_2426 and FEZ21_09870 as areA and PP_3839 as calA-II . IMPORTANCE Valorization of lignocellulose (nonedible plant matter) is of key interest for the sustainable production of chemicals from renewable resources. Lignin, one of the main constituents of...”
- Fatty Acid and Alcohol Metabolism in Pseudomonas putida: Functional Analysis Using Random Barcode Transposon Sequencing
Thompson, Applied and environmental microbiology 2020 (secret) - Killing Two Birds With One Stone - Strain Engineering Facilitates the Development of a Unique Rhamnolipid Production Process
Bator, Frontiers in bioengineering and biotechnology 2020 - “...undertake the conversion of ethanol to acetaldehyde. A SNP in the intergenic region before adhP (PP_3839), encoding an alcohol dehydrogenase, which is proposed to be located in the cytoplasm, was found ( Figure 4C ). The mutation upstream of adhP might alter the promoter activity upstream...”
- Differential proteomics and physiology of Pseudomonas putida KT2440 under filament-inducing conditions
Crabbé, BMC microbiology 2012 - “...PP_3611 PP_3668 gi|26990379 0.28* Catalase/peroxidase HPI PP_3765 gi|26990470 0.24* Transcriptional regulator MvaT, P16 subunit, putative PP_3839 AdhA gi|26990544 0.30* Alcohol dehydrogenase PP_4011 Icd gi|26990716 0.25* Isocitrate dehydrogenase, NADP-dependent PP_4034 gi|26990737 0.38* Allantoate amidohydrolase PP_4037 gi|26990739 0.32* Putative oxidoreductase PP_4038 gi|26990740 0.26* Dihydropyrimidine dehydrogenase PP_4116 AceA gi|26990810...”
- The RpoT regulon of Pseudomonas putida DOT-T1E and its role in stress endurance against solvents
Duque, Journal of bacteriology 2007 - “...PP3005 PP3007 PP3079 PP3122 PP3255 PP3365 PP3547 PP3754 PP3839 PP4064 PP4066 PP4067 PP4227 PP4228 PP4250 PP4251 PP4252 PP4253 PP4403 PP4561 PP4739 PP4870 PP4933...”
c1911 alcohol dehydrogenase from Escherichia coli CFT073
47% identity, 91% coverage
ECs2082 alcohol dehydrogenase from Escherichia coli O157:H7 str. Sakai
47% identity, 91% coverage
L2164_11250 alcohol dehydrogenase AdhP from Pectobacterium brasiliense
44% identity, 97% coverage
- A data catalogue of alcohol dehydrogenases in the genome of a tissue macerating Pectobacterium brasiliense isolated from potato in South Africa
Otun, Data in brief 2024 - “...dehydrogenase L2164_06900 MCG5048428.1 S-(hydroxymethyl)glutathione dehydrogenase/class III alcohol dehydrogenase L2164_06900 MCG5048428.1 S-(hydroxymethyl)glutathione dehydrogenase/class III alcohol dehydrogenase L2164_11250 MCG5049273.1 Alcohol dehydrogenase AdhP L2164_12100 MCG5049440.1 Iron-containing alcohol dehydrogenase L2164_12815 MCG5049582.1 Zinc-binding alcohol dehydrogenase family protein L2164_13090 MCG5049632.1 NAD(P)-dependent alcohol dehydrogenase L2164_17495 MCG5050486.1 Iron-containing alcohol dehydrogenase family protein L2164_19300 MCG5050844.1...”
YddN / b1478 ethanol dehydrogenase / alcohol dehydrogenase (EC 1.1.1.1) from Escherichia coli K-12 substr. MG1655 (see 4 papers)
adhP / P39451 ethanol dehydrogenase / alcohol dehydrogenase (EC 1.1.1.1) from Escherichia coli (strain K12) (see 5 papers)
4gkvB / P39451 Structure of escherichia coli adhp (ethanol-inducible dehydrogenase) with bound NAD (see paper)
b1478 alcohol dehydrogenase from Escherichia coli str. K-12 substr. MG1655
P39451 Alcohol dehydrogenase, propanol-preferring from Escherichia coli (strain K12)
ECBD_2161 Alcohol dehydrogenase zinc-binding domain protein from Escherichia coli 'BL21-Gold(DE3)pLysS AG'
47% identity, 91% coverage
- Ligands: peptide; nicotinamide-adenine-dinucleotide; zinc ion (4gkvB)
- Ferric Citrate Uptake Is a Virulence Factor in Uropathogenic Escherichia coli
Frick-Cheng, mBio 2022 - “...iron limitation Gene Product description Log 2 FC a Locus tag adhP Alcohol dehydrogenase 4.6 b1478 aroF Phospho-2-dehydro-3-deoxyheptonate aldolase 4.1 EICMKPFN_03556 bioA Adenosylmethionine-8-amino-7-oxononanoate aminotransferase 4.0 b0774 cirA Outer membrane receptor for ferrienterochelin and colicins 5.0 b2155 EICMKPFN_01803 Phosphate starvation-inducible protein 3.9 EICMKPFN_01803 EICMKPFN_02077 Hypothetical protein 4.2...”
- Genome-scale analysis of escherichia coli FNR reveals complex features of transcription factor binding
Myers, PLoS genetics 2013 - “...2,3-Bisphosphoglycerate-Dependent Phosphoglycerate Mutase Repressed cydDC b0887 Glutathione/Cysteine Transporter Repressed chaA b1216 Sodium/Proton Antiporter Repressed adhP b1478 Ethanol Dehydrogenase/Alcohol Dehydrogenase Repressed sodB b1656 Iron-Containing Superoxide Dismutase Repressed yobA-yebZY b1841 Conserved Protein Repressed dld b2133 Lactate Dehydrogenase Repressed folE-yeiB b2153 GTP Cyclohydrolase I Repressed eco b2209 Ecotin Homodimer/Serine...”
- 18th Congress of the European Hematology Association, Stockholm, Sweden, June 13–16, 2013
, Haematologica 2013 - Analysis of phage Mu DNA transposition by whole-genome Escherichia coli tiling arrays reveals a complex relationship to distribution of target selection protein B, transcription and chromosome architectural elements
Ge, Journal of biosciences 2011 - “...3334493 3.19 murA b3189 11 51200 51417 1.93 apaG b0049 11 1552612 1552733 3.14 maeA b1478 12 3103916 3104517 1.83 nupG b2964 12 4449949 4450142 3.14 ytfR b4230 13 48080 48753 1.77 kefC b0047 13 94377 94642 3.08 murE b0086 14 500178 500563 1.77 gsk b0477...”
- Genome-wide analysis of the general stress response network in Escherichia coli: sigmaS-dependent genes, promoters, and sigma factor selectivity
Weber, Journal of bacteriology 2005 - “...three different S-inducing conditions Function (reference) and gene b1478 b1927 b3012 b2097 b2661 b1619 b2720 b0186 b1469 b1467 b0871 b4051 b2464 b1519 b2465...”
- Chromosomal deletion formation system based on Tn5 double transposition: use for making minimal genomes and essential gene analysis
Goryshin, Genome research 2003 - “...fimD; fimF; fimG rpoZ; gmk fdnG; fdnH; fdnl; b1477; b1478; sfcA; rpsV; b1481; osmC; b1483-1491; xasA; gadB 650 Genome Research www.genome.org Grow w/o IPTG Y Y...”
- Structure and Dynamics of a Thermostable Alcohol Dehydrogenase from the Antarctic Psychrophile Moraxella sp. TAE123
Petratos, ACS omega 2020 - “...bacteria thriving in environments of varying temperatures, namely, Escherichia coli ( Ec ADH, UniProtKB ID P39451), 12 Geobacillus stearothermophilus ( Gs ADH, UniProtKB ID P42328), 13 and Thermus sp. ATN1 ( Th ADH, UniProtKB ID B2ZRE3). 14 Moreover, circular dichroism (CD) spectropolarimetry and enzyme kinetics of...”
- “...ID 4Z6K) (UniProtKB: Q8GIX7) Ec ADH:NAD + 1.28 54.1 24.1 (PDB ID 4GKV) (314) (UniProtKB: P39451) 1.46 (1195) Gs ADH:CF 3 CH 2 OH 0.70 1.33 25.9 (PDB ID 1RJW) (336) (311) (UniProtKB: P42328) 0.75 1.51 (1347) (1176) Th ADH:NAD + 1.56 1.60 1.59 (PDB ID...”
- Engineering RNA endonucleases with customized sequence specificities
Choudhury, Nature communications 2012 - “...site with a single mis-match from the target ( Fig. 3c ) and the adhP (ECBD_2161) gene does not harbour a similar site. A significant decrease in RNA level was observed only for lacZ but not for eutE or yjcS (both containing a single target site)...”
CH_124188 alcohol dehydrogenase 1 alcohol dehydrogenase [Cochliobolus lunatus] from Magnaporthe grisea 70-15 (see 2 papers)
43% identity, 96% coverage
CTRG_06113, XP_002546635 alcohol dehydrogenase 1 from Candida tropicalis MYA-3404
42% identity, 83% coverage
- Characteristics of Extracellular Vesicles Released by the Pathogenic Yeast-Like Fungi Candida glabrata, Candida parapsilosis and Candida tropicalis
Karkowska-Kuleta, Cells 2020 - “...+ + gi|255722954 (XP_002546411) lysophospholipase 1 precursor CTRG_05889 (Plb3) + gi|255723403 (XP_002546635) alcohol dehydrogenase 1 CTRG_06113 (Adh1) + gi|255723898 (XP_002546878) putative GPI-anchored protein CTRG_01183 (Pga17) + + gi|255724450 (XP_002547154) pyruvate kinase CTRG_01460 (Cdc19) + gi|255725506 (XP_002547682) protein of unknown function CTRG_01989 + + + gi|255725714 (XP_002547786)...”
- “...protein CTRG_05838 (Hyr3) + + + gi|255722954 (XP_002546411) lysophospholipase 1 precursor CTRG_05889 (Plb3) + gi|255723403 (XP_002546635) alcohol dehydrogenase 1 CTRG_06113 (Adh1) + gi|255723898 (XP_002546878) putative GPI-anchored protein CTRG_01183 (Pga17) + + gi|255724450 (XP_002547154) pyruvate kinase CTRG_01460 (Cdc19) + gi|255725506 (XP_002547682) protein of unknown function CTRG_01989 +...”
Q4WTV5 alcohol dehydrogenase from Aspergillus fumigatus (strain ATCC MYA-4609 / CBS 101355 / FGSC A1100 / Af293)
AFUA_5G06240, Afu5g06240 alcohol dehydrogenase, putative from Aspergillus fumigatus Af293
45% identity, 98% coverage
- The proteomic signature of Aspergillus fumigatus during early development
Cagas, Molecular & cellular proteomics : MCP 2011 - “...Q4WJH1 Q4X0L0 Q6MYW4 Q4WAI8 Q4WYW9 Q4WY39 Q6MY48 Q4WTV5 Q4WCP3 Q4WC88 P61832 Q4WIE3 Q4X1I3 Q4WGP3 Q4WLN1 Q4WDF5 AFUA_5G06240 AFUA_3G06460 AFUA_7G00250...”
- Fungal and host protein persulfidation are functionally correlated and modulate both virulence and antifungal response
Sueiro-Olivares, PLoS biology 2021 - “...persulfidated proteins ( S2 Table ), and one of them, AlcC (UniProt: A0A0J5PVH3; Gene ID: AFUA_5G06240), has been implicated in A . fumigatus virulence [ 36 ]. Therefore, we also measured alcohol dehydrogenase activity from crude protein extracts and found that the activity was significantly increased...”
- Proteomic and Metabolomic Characteristics of Extremophilic Fungi Under Simulated Mars Conditions
Blachowicz, Frontiers in microbiology 2019 - “...exhibited decreased abundance were malate and alcohol dehydrogenases [AFUA_6G05210 ( Teutschbein et al., 2010 ), AFUA_5G06240 ( Cagas et al., 2011 ), respectively] and mannose-6-phosphate isomerase (AFUA_4G08410) ( Gautam et al., 2011 ). Several proteins with increased abundance were involved in response to stress ( Table...”
- “...dehydrogenase complex subunit alpha AFUA_6G05210 -1.18 1.36E-04 Malate dehydrogenase involved in the citric acid cycle AFUA_5G06240 AlcC -1.22 1.83E-04 Alcohol dehydrogenase AFUA_4G08410 -2.23 1.53E-02 Mannose-6-phosphate isomerase Log2 fold change of ISSFT-021-30 compared to ISSFT-021 ( P < 0.05). Table 5 Differentially expressed proteins involved in response...”
- Aspergillus fumigatus Challenged by Human Dendritic Cells: Metabolic and Regulatory Pathway Responses Testify a Tight Battle
Srivastava, Frontiers in cellular and infection microbiology 2019 - “...infection of DCs induced upregulated expression of 4-aminobutyrate transaminase GatA (AFUA_5G06680- GATA) and alcohol dehydrogenases (AFUA_5G06240 - ALDH2, AAA32684.1 - ADH). The same experiment revealed a decrease of alkaline phosphatase (AFUA_6G08710 ALP), branched-chain amino acid aminotransferase (AFUA_1G01680 BCAAA), and GTP cyclohydrolase I (AFUA_5G03140 - GTPCH) (...”
- Analysis of an Intrinsic Mycovirus Associated With Reduced Virulence of the Human Pathogenic Fungus Aspergillus fumigatus
Takahashi-Nakaguchi, Frontiers in microbiology 2019 - “...related to carbohydrates, amino acids, and secondary metabolite synthesis were detected (AciA/Fdh; AFUA_6G04920, alcohol dehydrogenase; AFUA_5G06240, PdcA; AFUA_3G11070, indoleamine 2,3-dioxygenase family protein; AFUA_7G02010, isochorismatase family hydrolase; AFUA_6G12220, copper amine oxidase; AFUA_3G14590, acetyl-CoA-acetyltransferase; AFUA_6G14200). Several transcripts related to energy metabolism were also detected (FAD-dependent oxidoreductase; AFUA_7G05070, 3-hydroxyacyl-CoA...”
- The Transcription Factor ZafA Regulates the Homeostatic and Adaptive Response to Zinc Starvation in Aspergillus fumigatus
Vicentefranqueira, Genes 2018 - “...0.2 AFUA_5G03920 NZR hapX 12.2 1.5 1.2 0.1 AFUA_5G04130 Control phoA 1.1 0.1 1.3 0.2 AFUA_5G06240 DZR alcC 26.8 1.9 3.8 0.5 Repression AFUA_5G06270 NZR hemA 1.8 0.2 1.0 0.1 AFUA_5G08090 DZR pyroA 2.7 0.3 1.8 0.2 Induction AFUA_5G09240 DZR sodA / sod1 4.7 0.7 7.3...”
- “...ZR0* AFUA_5G03060 - R 807 793 GCGCGCAAGGTACTT ZR0* AFUA_5G05710 - R 100 86 TTCACCAAGGTTTTG ZR0* AFUA_5G06240 alcC D 595 581 TCCCCCAGGGTACAT ZR8 AFUA_5G09240 sodA / sod1 R 198 184 ATTCACAGGGTATTA ZR0* AFUA_5G12780 - D 99 85 ACTCCCAAGGTACTC ZR0 AFUA_5G13940 - R 231 217 TCTGTCAGGGTCTGT ZR8 AFUA_6G00690...”
- The Aspergillus fumigatus sitA Phosphatase Homologue Is Important for Adhesion, Cell Wall Integrity, Biofilm Formation, and Virulence
Bom, Eukaryotic cell 2015 - “...Adh1, alcohol dehydrogenase; predicted gene pair with AFUA_5G06240 (alcC); induced by L-tyrosine; transcript upregulated in conidia exposed to neutrophils 65 42...”
- Identification of hypoxia-inducible target genes of Aspergillus fumigatus by transcriptome analysis reveals cellular respiration as an important contributor to hypoxic survival
Kroll, Eukaryotic cell 2014 - “...along with two alcohol dehydrogenase genes, alcC (AFUA_5G06240) and adh2 (AFUA_2G10960). In agreement with previous findings from other fungi that the...”
- Investigation of Aspergillus fumigatus biofilm formation by various "omics" approaches
Muszkieta, Frontiers in microbiology 2013 - “...2.57 AFUA_8G05600 Hypothetical protein 0.07 3.84 0.16 2.64 AFUA_1G13800 mfs-multidrug-resistance transporter 0.28 1.84 0.16 2.65 AFUA_5G06240 Alcohol dehydrogenase. putative 0.09 3.47 0.15 2.72 AFUA_8G05580 Coenzyme A transferase PsecoA 0.19 2.40 0.15 2.76 AFUA_4G08960 GPI anchored protein, putative 0.19 2.40 0.14 2.86 AFUA_2G13830 Conserved hypothetical protein 0.41...”
- “...synthetase FacA 2.40 0.29 16 AFUA_5G02370 6 Vacuolar ATP synthase catalytic subunit A 0.39 17 AFUA_5G06240 18 Alcohol dehydrogenase, putative 0.24 0.15 23 0.35 18 AFUA_5G09910 33 Nitroreductase family protein 0.38 0.12 19 AFUA_5G14680 29 Conserved hypothetical protein 0.20 0.25 30 0.32 31 0.14 20 AFUA_6G02420...”
- More
A1YDT6 alcohol dehydrogenase from Cochliobolus lunatus
42% identity, 97% coverage
- Mold allergens in respiratory allergy: from structure to therapy.
Twaroch, Allergy, asthma & immunology research 2015 - “...serine protease 54 81 16 242 + B3V0K8 Cur l ADH alcohol dehydrogenase 37.6 - A1YDT6 Cur l GST 81 glutathione-S-transferase 26.9 - Q45X98 Cur l MnSOD Mn superoxide dismutase 21.4 - Q1EHH3 Cur l Oryzin oryzin, Asp f 13-like protein 14.2 - Q1EHH2 Cur l...”
CNG00600 mannitol-1-phosphate dehydrogenase from Cryptococcus neoformans var. neoformans JEC21
42% identity, 81% coverage
- Brain inositol is a novel stimulator for promoting Cryptococcus penetration of the blood-brain barrier
Liu, PLoS pathogens 2013 - “...CNF04450 CNAG_07660 Pyruvate dehydrogenase 3.51 CNA01050 CNAG_00115 Sorbitol dehydrogenase 3.33 CNJ00950 CNAG_04659 Pyruvate decarboxylase 3.23 CNG00600 CNAG_07745 Mannitol-1-phosphate dehydrogenase 3.00 CNC06440 CNAG_01539 Inositol-1-phosphate synthase (Ino1) 2.79 CNE01560 CNAG_02399 Glutathione reductase 2.72 CND00180 CNAG_00879 Glutamate dehydrogenase 2.63 CNA04610 CNAG_07363 Isocitrate dehydrogenase 2.59 CNL04840 CNAG_05138 Exo-beta-1,3-glucanase 2.54 CNC02410...”
- Metabolic adaptation in Cryptococcus neoformans during early murine pulmonary infection
Hu, Molecular microbiology 2008 - “...95 30 5 CND01490 XM_570285 Cu/Zn superoxide dismutase, SOD1 ATAAGCTTTC 12 0 74 14 25 CNG00600 XM_571772 mannitol-1-phosphate dehydrogenase CATTTTATGT 14 0 35 16 24 CNM01520 XM_568451 heat shock protein 90 TAACATAATG 16 0 30 3 17 CNA01260 XM_567249 glutathione S-transferase TGTTTCTACA 2 1 24 3...”
H9DXW0 alcohol dehydrogenase from Candida parapsilosis
42% identity, 97% coverage
CPAR2_502580 uncharacterized protein from Candida parapsilosis
42% identity, 84% coverage
- Proteomics Readjustment of the Yarrowia lipolytica Yeast in Response to Increased Temperature and Alkaline Stress
Sekova, Microorganisms 2021 - “...identified (No. 60), and two 12 kDa fragments of two different carbonyl reductases, CPCR1 and CPAR2_502580 (zones 56 and 58) were detected ( Table 6 ). Nucleoside diphosphate kinase CPAR2_101390 (No. 59) and 22 kDa chaperone HSP70 Ssa2 HSP70 (zone 66) were two other original proteins...”
- “...stress. Under combined stress, we detected four original proteins. Firstly, there were CPCR1 (fragment) and CPAR2_502580 carbonyl reductases. Carbonyl reductases are known to be involved in the detoxification of cytotoxic products of lipid peroxidation [ 46 , 47 ]. ATP synthase subunit 5 CPAR2_503440, which contains...”
- Characteristics of Extracellular Vesicles Released by the Pathogenic Yeast-Like Fungi Candida glabrata, Candida parapsilosis and Candida tropicalis
Karkowska-Kuleta, Cells 2020 - “...+ + gi|354547255 (CCE43989) hypothetical protein CPAR2_502140 GPI-linked chitinase (Cht2) + gi|354547299 (CCE44033) hypothetical protein CPAR2_502580 alcohol dehydrogenase (Adh1) + gi|354547623 (CCE44358) hypothetical protein CPAR2_401600 1,3-beta-glucosyltransferase, cell wall enzyme (Bgl2) + + + gi|354547664 (CCE44399) hypothetical protein CPAR2_402000 GPI-anchored protein of cell wall (Pga30) + gi|354548052...”
- Moonlighting proteins are variably exposed at the cell surfaces of Candida glabrata, Candida parapsilosis and Candida tropicalis under certain growth conditions
Karkowska-Kuleta, BMC microbiology 2019 - “...hypothetical protein CPAR2_212210 [ Candida parapsilosis ] NAD-aldehyde dehydrogenase (Ald5) 0.23428 gi|354,547,299 (CCE44033) hypothetical protein CPAR2_502580 [ Candida parapsilosis ] alcohol dehydrogenase (Adh1) 0.13296 0.08365 0.13991 gi|354,547,586 (CCE44321) hypothetical protein CPAR2_401230 [ Candida parapsilosis ] fructose-bisphosphate aldolase (Fba1) 0.04268 Cell surface shaving of C. parapsilosis cultures...”
XP_003195433 Mannitol-1-phosphate dehydrogenase, putative from Cryptococcus gattii WM276
42% identity, 81% coverage
- Vaccine-mediated immune responses to experimental pulmonary Cryptococcus gattii infection in mice
Chaturvedi, PloS one 2014 - “...XP_003197291 5 15 10 Hypothetical protein CGB_M1360W 34 XP_003197248 5 13 11 Mannitol-1-phosphate dehydrogenase 45 XP_003195433 5 12 12 Mannitol-1-phosphate dehydrogenase 45 XP_003195433 4 12 13 Aldehyde reductase 37 XP_003196615 3 9 a All proteins were identified with 100% probability in Scaffold. b Molecular weight of...”
- “...8 48 12 Translation initiation factor 5a 17 XP_003196060 2 19 13 Mannitol-1-phosphate dehydrogenase 45 XP_003195433 6 13 14 Mannitol-1-phosphate dehydrogenase 45 XP_003195433 4 11 15 Mannitol-1-phosphate dehydrogenase 45 XP_003195433 4 9 16 Oxidoreductase 33 XP_003193567 2 7 a All proteins were identified with 100% probability...”
CNE00710 mannitol-1-phosphate dehydrogenase from Cryptococcus neoformans var. neoformans JEC21
41% identity, 95% coverage
T5A9I4 alcohol dehydrogenase from Ophiocordyceps sinensis (strain Co18 / CGMCC 3.14243)
41% identity, 96% coverage
CNAG_02489 alcohol dehydrogenase, propanol-preferring from Cryptococcus neoformans var. grubii H99
42% identity, 95% coverage
- Cryptococcus neoformans resists to drastic conditions by switching to viable but non-culturable cell phenotype
Hommel, PLoS pathogens 2019 - “...analysis. Metabolic pathways Genes Corrected p value (FDR 1%) Fatty acid degradation CNAG_00490, CNAG_00524, CNAG_03019, CNAG_02489, CNAG_06628, CNAG_07747, CNAG_04531, CNAG_04688 1.20E-09 Valine, leucine and isoleucine degradation CNAG_00484, CNAG_00490, CNAG_00524, CNAG_03067, CNAG_06628, CNAG_04531, CNAG_04351, CNAG_04688 2.40E-08 Fatty acid metabolism CNAG_00490, CNAG_00524, CNAG_03019, CNAG_07747, CNAG_04531, CNAG_04688 9.50E-07 Propanoate...”
- “...CNAG_05303, CNAG_04531, CNAG_04351, CNAG_04217, CNAG_04688 4.00E-05 Biosynthesis of secondary metabolites CNAG_00484, CNAG_00490, CNAG_00524, CNAG_00797, CNAG_03067, CNAG_02489, CNAG_06628, CNAG_04531, CNAG_04217, CNAG_04688, CNAG_06431 2.60E-04 Peroxisome CNAG_00537, CNAG_03067, CNAG_03019, CNAG_06551, CNAG_07747 2.90E-04 Metabolic pathways CNAG_00484, CNAG_00490, CNAG_00524, CNAG_00797, CNAG_00826, CNAG_03067, CNAG_03019, CNAG_01540, CNAG_02489, CNAG_06628, CNAG_07747, CNAG_05653, CNAG_05303, CNAG_04531, CNAG_04351,...”
- Investigation of Cryptococcus neoformans magnesium transporters reveals important role of vacuolar magnesium transporter in regulating fungal virulence factors
Suo, MicrobiologyOpen 2018 - “...Log 2 ( MGT2 + Mg v H99) b Description CNAG_03502 4.28 3.44 Magnesium transporter CNAG_02489 1.20 2.37 Alcohol dehydrogenase CNAG_03772 0.92 2.28 Glucose transporter CNAG_07788 1.62 1.98 Unknown CNAG_05212 2.08 1.72 Unknown CNAG_07819 1.33 1.64 Unknown CNAG_05487 1.65 1.61 Unknown CNAG_07845 1.84 1.41 Unknown CNAG_05874...”
- Galectin-3 impacts Cryptococcus neoformans infection through direct antifungal effects
Almeida, Nature communications 2017 - “...SP family, solute carrier family 2 (myo-inositol transporter), member 13 XM_012194787.1 3.44 0.0000 0.1 1.4 CNAG_02489 Alcohol dehydrogenase, propanol-preferring XM_012194657.1 3.20 0.0000 6.1 56.7 CNAG_02269 Autophagy-like protein 18 Atg18 XM_012191442.1 3.12 0.0000 2.4 21.4 CNAG_00598 Nicotinamide mononucleotide permease XM_012198344.1 2.87 0.0000 281.5 2069.0 CNAG_05387 Galactose transporter...”
AO090005000125 No description from Aspergillus oryzae RIB40
41% identity, 93% coverage
EF1826 alcohol dehydrogenase, zinc-containing from Enterococcus faecalis V583
42% identity, 98% coverage
CCM_02484 alcohol dehydrogenase 1 from Cordyceps militaris CM01
42% identity, 97% coverage
- Metabolic comparison of aerial and submerged mycelia formed in the liquid surface culture of Cordyceps militaris
Suparmin, MicrobiologyOpen 2019 - “...but downregulated in its aerial mycelia on the same culture time. Alcohol dehydrogenase 1 (ADH, CCM_02484) displayed the same pattern of expression and was upregulated in the submerged mycelia at 12th day but not in the aerial mycelia (Figure 5 ). Six putative ADHs (CCM_01806, CCM_09633,...”
- “...by alcohol dehydrogenase (ADH; CCM_09633), aldehyde dehydrogenase (ALDH; CCM_02203), hexokinase (HK; CCM_06280), alcohol dehydrogenase (ADH; CCM_02484), succinate dehydrogenase (SDH; CCM_07146), glucose6phosphate1dehydrogenase (G6PDH; CCM_06983), 5nucleotidase (5NT; CCM_00622), and adenylate cyclase, putative (ADCY; CCM_02396) in the submerged mycelia. In contrast, in the aerial mycelia, only adenylate cyclase, putative...”
A2QAN5 alcohol dehydrogenase from Aspergillus niger (strain ATCC MYA-4892 / CBS 513.88 / FGSC A1513)
An01g12170 uncharacterized protein from Aspergillus niger
42% identity, 92% coverage
RHTO_03062 alcohol dehydrogenase from Rhodotorula toruloides NP11
41% identity, 95% coverage
- Development of a dedicated Golden Gate Assembly Platform (RtGGA) for Rhodotorula toruloides
Bonturi, Metabolic engineering communications 2022 - “...named as GPD1 in R. toruloides 's literature, RHTO_03746), alcohol dehydrogenase 2 ( ADH2 , RHTO_03062), xylose reductase ( XYL1 , RHTO_03963), glucose 6-phosphate isomerase ( PGI , RHTO_04058), and 1,6-bisphosphatealdolase ( FBA , RHTO_03043) ( Daz et al., 2018 ; Wang et al., 2016 )....”
- From a genome assembly to full regulatory network prediction: the case study of Rhodotorula toruloides putative Haa1-regulon
Oliveira, BMC bioinformatics 2021 - “...the balance between energy generation and key anabolic processes [ 35 , 36 ], and RHTO_03062 which is homologous to the ADH genes, encoding alcohol dehydrogenases in S. cerevisiae . Fig. 5 Inferred Regulon Venn Diagram, of the Haa1p transcription factor targets, considering the documented regulatory...”
- Proteome analysis of xylose metabolism in Rhodotorula toruloides during lipid production
Tiukova, Biotechnology for biofuels 2019 - “...decreased twofold during lipid accumulation on both carbon sources while levels of alcohol dehydrogenase (ADH, Rhto_03062) decreased sharply by 588- and 1024-fold on glucose and xylose, respectively. This suggests rechannelling of carbon towards more energy-efficient carbon utilization, the pyruvate dehydrogenasecitrate synthaseATP-citrate lyase path rather than to...”
XP_503672 YALI0E07766p from Yarrowia lipolytica CLIB122
38% identity, 96% coverage
AO090038000108 No description from Aspergillus oryzae RIB40
42% identity, 93% coverage
LSA1702 Putative zinc-containing alcohol dehydrogenase (oxidoreductase) from Lactobacillus sakei subsp. sakei 23K
38% identity, 98% coverage
- Global transcriptome response in Lactobacillus sakei during growth on ribose
McLeod, BMC microbiology 2011 - “...LSA1553 lsa1553 Putative hydrolase, haloacid dehalogenase family -0.6 LSA1559 lsa1559 Putative oxidoreductase 0.6 1.1 0.7 LSA1702 lsa1702 Putative zinc-containing alcohol dehydrogenase (oxidoreductase) 1.1 LSA1712 lsa1712 Putative nitroreductase (oxidoreductase) -0.7 -0.8 LSA1832 lsa1832 Putative zinc-containing alcohol dehydrogenase (oxidoreductase) 1.0 LSA1835 lsa1835 Putative zinc-containing alcohol dehydrogenase (oxidoreductase) -0.7...”
Pc12g10630 uncharacterized protein from Penicillium rubens
39% identity, 94% coverage
- Studying the Gene Expression of Penicillium rubens Under the Effect of Eight Essential Oils
Kisová, Antibiotics (Basel, Switzerland) 2020 - “...metabolic pathways, encoded by multiple gene clusters, increased transcriptional levels were achieved: at glycolysis (Pc18g01490, Pc12g10630, Pc20g01630, Pc12g13500, Pc20g04410 and Pc12g16040); the pentose phosphate pathway (Pc12g02790, Pc13g14570, Pc12g13500 and Pc20g04410); fructose and mannose metabolisms (Pc16g12970, Pc22g09390, Pc21g05470, Pc20g01550, Pc13g12020, Pc12g09190, Pc12g13500, Pc21g04410, Pc21g04400 and Pc16g10970) and...”
CC77DRAFT_1004828 GroES-like protein from Alternaria alternata
39% identity, 96% coverage
- Combination of Bacillus tequilensis with difenoconazole to control pear black spot and the related synergistic mechanism
Bi, Frontiers in microbiology 2024 - “...used for fluorescence quantification. Gene name Gene function description Forward primer (5-3) Reverse primer (5-3) CC77DRAFT_1004828 (down) Glycolysis/Gluconeogenesis TGTTGGATCAGCTGTGGGAT ACAACTCTGCCCTGTAGCTT CC77DRAFT_1005031 (down) Citrate cycle (TCA cycle) TTCCCCAAAGATCTCCACCC GCAGCAATGGTAGGCAGTTT CC77DRAFT_1024999 (down) Oxidative phosphorylation TACTGAGCACTGGGGAAAGG CTGTGTCTTTCTCCATCGCG CC77DRAFT_948756 (down) cytochrome P450 ATGGCTTCTAAGGATCCGGG GACTGTGTTGGCTAGGAGGT CC77DRAFT_928877 (down) Fatty acid biosynthesis GTGTCTTTGCTAGCTACGCC...”
An13g00950 uncharacterized protein from Aspergillus niger
39% identity, 90% coverage
- The effect of natamycin on the transcriptome of conidia of Aspergillus niger
van, Studies in mycology 2013 - “...up-regulation in the presence of natamycin ( Table 7 ). This included an alcohol dehydrogenase (An13g00950, 39-fold), D-lactate dehydrogenase (An11g09520, 12.4-fold); pyruvate decarboxylate (An 09g01030, 11.3-fold); isocitrate lyase (An01g09270, 81-fold) and a malate synthase gene (An15g01860, 52-fold). A gene with similarity to 2-methylisocitrate lyase (An12g07630) that...”
Minf_0269 Zn-dependent alcohol dehydrogenase from Methylacidiphilum infernorum V4
40% identity, 93% coverage
Q17334 Alcohol dehydrogenase 1 from Caenorhabditis elegans
NP_505991 Alcohol dehydrogenase 1 from Caenorhabditis elegans
38% identity, 97% coverage
PITG_11293 alcohol dehydrogenase, putative from Phytophthora infestans T30-4
39% identity, 95% coverage
PADG_01174 uncharacterized protein from Paracoccidioides brasiliensis Pb18
36% identity, 92% coverage
- Global Molecular Response of Paracoccidioides brasiliensis to Zinc Deprivation: Analyses at Transcript, Protein and MicroRNA Levels
Mesquita, Journal of fungi (Basel, Switzerland) 2023 - “...S7 ). The decreased zinc transcripts encoded to the Zn-dependent enzymes: two putative alcohol dehydrogenases (PADG_01174 and PADG_03859) and O-methyltransferase (PADG_02839). One transcript encoding the zinc transporter (ZRT2) belonging to the ZIP family was induced (PADG_06417). Although, there are no functional studies on Zn-transporters in P....”
- Prediction of Conserved Peptides of Paracoccidioides for Interferon-γ Release Assay: The First Step in the Development of a Lab-Based Approach for Immunological Assessment during Antifungal Therapy
Rosa, Journal of fungi (Basel, Switzerland) 2020 - “...had no similarity in alignment for any of the two species and for aldehyde dehydrogenase (PADG_01174), L-threonine-3-dehydrogenase (PAAG_00966), 1,2 dihydroxyl-3-keto-methylopentene-dioxygenase (gI226294753), 2.5 diceto-D-gluconic reductase A (giI295663891), glutamate reductase (giI295664022), aldehyde dehydrogenase (PAAG_05249), enolase (ABQ45367), aminobutyrate aminotransferase (PADG_02214), and PADG_34 proteases. Another 63 proteins were excluded for...”
- “...0.0 97% 100% Actin F protein subunit uptake protein PADG_07756 0.0 100% 100% Alcohol dehydrogenase PADG_01174 0.0 100% 97% Alpha-1,2 mannosyltransferase PAAG_02462 0.0 100% 98% Alpha-1,2 mannosyltransferase KTR1 PAAG_07238 0.0 97% 100% Adenosillomocysteine PADG_02859 0.0 99% 100% Aminotransferase PAAG_03045 0.0 100% 98% Aminotransferase PAAG_00053 0.0 98%...”
- Predicting copper-, iron-, and zinc-binding proteins in pathogenic species of the Paracoccidioides genus
Tristão, Frontiers in microbiology 2014 - “...Chhatwal, 2003 Zn PAAG_06596 PABG_02619 None alcohol dehydrogenase Pancholi and Chhatwal, 2003 Zn PAAG_06715 PABG_02727 PADG_01174 alcohol dehydrogenase Pancholi and Chhatwal, 2003 Zn PAAG_05227 PABG_07631 PADG_05031 alcohol dehydrogenase Pancholi and Chhatwal, 2003 Zn PAAG_04541 PABG_04316 PADG_04701 alcohol dehydrogenase GroES domain-containing protein Pancholi and Chhatwal, 2003 Zn...”
A3MVR8 alcohol dehydrogenase (EC 1.1.1.1) from Pyrobaculum calidifontis (see paper)
Pcal_1311 Alcohol dehydrogenase GroES domain protein from Pyrobaculum calidifontis JCM 11548
38% identity, 97% coverage
AFUA_2G10960, Afu2g10960 alcohol dehydrogenase, putative from Aspergillus fumigatus Af293
40% identity, 97% coverage
- RNAseq analysis of Aspergillus fumigatus in blood reveals a just wait and see resting stage behavior
Irmer, BMC genomics 2015 - “...have cyanide hydratase activity, nitrilase activity and role in cyanide catabolic process Oxidation-reduction process GO:0055114 AFUA_2G10960 adh2 putative alcohol dehydrogenase Adh2p, in S. cerevisiae is responsible for catalyzing the initial step in the utilization of ethanol as a carbon source AFUA_2G11250 aryl-alcohol dehydrogenase Aad14, unknown function...”
- “...predicted to be involved in oxidative stress are up-regulated at B180s like three alcohol hydrogenases AFUA_2G10960 (alcohol dehydrogenase Adh2), AFUA_2G11250 (aryl-alcohol dehydrogenase Aad14), AFUA_2G15930 (alcohol dehydrogenase, zinc-containing) and the putative thioredoxin reductase encoding gene AFUA_4G12990 (Aspf29, an allergen and putative thioredoxin TrxA). Iron starvation Under less...”
- Identification of hypoxia-inducible target genes of Aspergillus fumigatus by transcriptome analysis reveals cellular respiration as an important contributor to hypoxic survival
Kroll, Eukaryotic cell 2014 - “...two alcohol dehydrogenase genes, alcC (AFUA_5G06240) and adh2 (AFUA_2G10960). In agreement with previous findings from other fungi that the GABA shunt could...”
- Transcriptomic and proteomic analyses of the Aspergillus fumigatus hypoxia response using an oxygen-controlled fermenter
Barker, BMC genomics 2012 - “...of the most highly induced transcripts, along with two alcohol dehydrogenases, alcC (Afu5g06240) and adh2 (Afu2g10960). PdcA and AlcC were both recently confirmed to be required for ethanol fermentation in A. fumigatus , and AlcC was demonstrated to have an important but undefined role in fungal...”
PITG_10292 alcohol dehydrogenase, putative from Phytophthora infestans T30-4
40% identity, 82% coverage
- Switchable Nitroproteome States of Phytophthora infestans Biology and Pathobiology
Izbiańska, Frontiers in microbiology 2019 - “...RxLR effector peptide protein 24 PITG_06059 Hydrolase activity / pathogenesis S24 PREDICTED: Alcohol dehydrogenase 103 PITG_10292 Oxidoreductase activity / others S25 PREDICTED: Type I inositol-3,4-bisphosphate 4-phosphatase 48 PITG_12548 Signal transduction S26 Peroxiredoxin-like protein 123 PITG_00585 Cell redox homeostasis / response to stress S27 Carbonic anhydrase 292...”
AO090003000261 No description from Aspergillus oryzae RIB40
40% identity, 93% coverage
- Genomic and transcriptomic comparison of Aspergillus oryzae strains: a case study in soy sauce koji fermentation
Zhong, Journal of industrial microbiology & biotechnology 2018 - “...enoA 4.2.1.11 Enolase 0.13 1.60 0.24 8 AO090003000661 4.1.1.1 Pyruvate decarboxylase 0.31 1.64 1.50 9 AO090003000261 1.1.1.1 Alcohol dehydrogenase 2.45 1.29 2.33 10 AO090023000467 1.2.1.3 Aldehyde dehydrogenase 1.03 0.85 0.14 10 AO090026000741 1.2.1.5 Aldehyde dehydrogenase 1.13 0.19 0.80 11 AO090003000174 4.1.1.49 Phosphoenolpyruvate carboxykinase 1.90 4.62 0.96...”
- “...synthase ( fas1 , AO090011000046 ), aldehyde dehydrogenase ( AO090023000467 ), and alcohol dehydrogenases ( AO090003000261 , AO090003001407 ) were up-regulated in RD2. The up-regulation of these enzymes largely induced the accumulation of fatty acids, which can be further catabolized by up-regulated aldehyde dehydrogenases and alcohol...”
K441DRAFT_663665 GroES-like protein from Cenococcum geophilum 1.58
38% identity, 94% coverage
- Effects of High Temperature-Triggered Transcriptomics on the Physiological Adaptability of Cenococcum geophilum, an Ectomycorrhizal Fungus
Yan, Microorganisms 2022 - “...were validated for genes screened from shared ABC transport pathway, namely K441DRAFT_643842 and K441DRAFT_695880 (ACg07); K441DRAFT_663665 and K441DRAFT_672389 (ChCg28); K441DRAFT_587262 and K441DRAFT_702334 (ChCg100). Sensitive isolates were validated for genes screened from shared glyoxylate and dicarboxylate metabolism and fatty acid degradation pathways, namely K441DRAFT_36643 and K441DRAFT_618447 (ChCg01);...”
- “...the fatty acid degradation pathway ( Figure 8 a), among which the K441DRAFT_618447 and the K441DRAFT_663665 were shared by the 3 susceptible-isolates and 3 tolerant-isolates, respectively, and the expression levels of both genes decreased under temperature stress ( Table S5 ). For the ABC transporters pathway...”
PITG_10290 alcohol dehydrogenase, putative from Phytophthora infestans T30-4
38% identity, 79% coverage
- Comparative Transcriptome Analysis Revealed Genes Regulated by Histone Acetylation and Genes Related to Sex Hormone Biosynthesis in Phytophthora infestans
Wang, Frontiers in genetics 2020 - “...genes with significantly down-regulated expression levels in the HDST and H7ST strains were identified ( PITG_10290 , PITG_11293 , and PITG_11295 ) ( p < 0.05, Figure 7B ). Moreover, of the seven genes encoding 2-coumarate reductases, the expression of PITG_14479 was significantly up-regulated in the...”
- Dominance of Mating Type A1 and Indication of Epigenetic Effects During Early Stages of Mating in Phytophthora infestans
Tzelepis, Frontiers in microbiology 2020 - “...production and metabolism, such as FAD-dependent oxidoreductase ( PITG_03815 ) and dehydrogenases ( PITG_00908 , PITG_10290 ) ( Supplementary Table S4 ). Genes that encoded ATP-binding cassette proteins (ABC transporters; PITG_07717 , PITG_07716 , PITG_04787 ) were also up-regulated in the Swedish mating samples, whereas PITG_17956...”
PAAG_06715 alcohol dehydrogenase from Paracoccidioides lutzii Pb01
36% identity, 92% coverage
ADH2_EMENI / P54202 Alcohol dehydrogenase 2; Alcohol dehydrogenase II; ADH II; EC 1.1.1.1 from Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans) (see paper)
alcB alcohol dehydrogenase 2; EC 1.1.1.1 from Emericella nidulans (see paper)
37% identity, 93% coverage
- catalytic activity: a primary alcohol + NAD(+) = an aldehyde + NADH + H(+) (RHEA:10736)
catalytic activity: a secondary alcohol + NAD(+) = a ketone + NADH + H(+) (RHEA:10740)
cofactor: Zn(2+) (Binds 2 Zn(2+) ions per subunit.)
subunit: Homotetramer. - CharProtDB Description: Alcohol dehydrogenase II, has a predicted role in two-carbon compound metabolism; Source:AspGD
- No Chance to Survive: Mo-CBP3-PepII Synthetic Peptide Acts on Cryptococcus neoformans by Multiple Mechanisms of Action
Aguiar, Antibiotics (Basel, Switzerland) 2023 - “...Aspergillus niger Cytoplasm 1.782962796 Acyl-coenzyme A oxidase Q6FY63 Candida glabrata Peroxisome 1.03315885 Alcohol dehydrogenase 2 P54202 Emericella nidulans Cytoplasm 0.609201703 Protein Binding Rab proteins geranylgeranyltransferase component A P32864 Saccharomyces cerevisiae Nucleus 0.561076893 Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP22 P24384 Saccharomyces cerevisiae Unknown 0.815963494 Autophagy-related protein 11...”
PADG_01987 uncharacterized protein from Paracoccidioides brasiliensis Pb18
37% identity, 99% coverage
Q9Y9P9 alcohol dehydrogenase (EC 1.1.1.1) from Aeropyrum pernix (see 3 papers)
37% identity, 97% coverage
HCAG_06397 alcohol dehydrogenase II from Histoplasma mississippiense (nom. inval.)
36% identity, 92% coverage
1h2bB / Q9Y9P9 Crystal structure of the alcohol dehydrogenase from the hyperthermophilic archaeon aeropyrum pernix at 1.65a resolution (see paper)
37% identity, 97% coverage
- Ligands: octanoic acid (caprylic acid); nicotinamide-adenine-dinucleotide (acidic form); zinc ion (1h2bB)
AO090026000555 No description from Aspergillus oryzae RIB40
38% identity, 97% coverage
FVEG_13244 alcohol dehydrogenase from Fusarium verticillioides 7600
35% identity, 93% coverage
- Transcriptional differences between major Fusarium pathogens of maize, Fusarium verticillioides and Fusarium graminearum with different optimum growth temperatures
Liu, Frontiers in microbiology 2022 - “...in Fg), genes encoding homogentisate 1,2-dioxygenase (FVEG_09414 and FGRAMPH1_01G22307), and genes encoding alcohol dehydrogenase (propanol-preferring; FVEG_13244, FGRAMPH1_01G20639, and FGRAMPH1_01G15957). However, the expression of homologous genes that encode primary-amine oxidase were reduced in both species at 30C (FVEG_11764, FVEG_04368, FVEG_10879, and FVEG_04395 in FV4D, FVEG_15472, FVEG_10879, and...”
NOTN_ASPSM / E1ACQ9 Alcohol dehydrogenase notN; Notoamide biosynthesis cluster protein N; EC 1.1.1.1 from Aspergillus sp. (strain MF297-2) (see 3 papers)
35% identity, 100% coverage
- function: Alcohol dehydrogenase; part of the gene cluster that mediates the biosynthesis of notoamide, a fungal indole alkaloid that belongs to a family of natural products containing a characteristic bicyclo[2.2.2]diazaoctane core (PubMed:20722388). The first step of notoamide biosynthesis involves coupling of L-proline and L-tryptophan by the bimodular NRPS notE, to produce cyclo-L-tryptophan-L-proline called brevianamide F (PubMed:20722388). The reverse prenyltransferase notF then acts as a deoxybrevianamide E synthase and converts brevianamide F to deoxybrevianamide E via reverse prenylation at C-2 of the indole ring leading to the bicyclo[2.2.2]diazaoctane core (PubMed:20722388). Deoxybrevianamide E is further hydroxylated at C-6 of the indole ring, likely catalyzed by the cytochrome P450 monooxygenase notG, to yield 6-hydroxy-deoxybrevianamide E (Probable). 6-hydroxy-deoxybrevianamide E is a specific substrate of the prenyltransferase notC for normal prenylation at C-7 to produce 6- hydroxy-7-prenyl-deoxybrevianamide, also called notoamide S (PubMed:20722388). As the proposed pivotal branching point in notoamide biosynthesis, notoamide S can be diverted to notoamide E through an oxidative pyran ring closure putatively catalyzed by either notH cytochrome P450 monooxygenase or the notD FAD-linked oxidoreductase (Probable). This step would be followed by an indole 2,3-epoxidation- initiated pinacol-like rearrangement catalyzed by the notB FAD- dependent monooxygenase leading to the formation of notoamide C and notoamide D (PubMed:22188465). On the other hand notoamide S is converted to notoamide T by notH (or notD), a bifunctional oxidase that also functions as the intramolecular Diels-Alderase responsible for generation of (+)-notoamide T (Probable). To generate antipodal (-)- notoaminide T, notH' (or notD') in Aspergillus versicolor is expected to catalyze a Diels-Alder reaction leading to the opposite stereochemistry (Probable). The remaining oxidoreductase notD (or notH) likely catalyzes the oxidative pyran ring formation to yield (+)- stephacidin A (Probable). The FAD-dependent monooxygenase notI is highly similar to notB and is predicted to catalyze a similar conversion from (+)-stephacidin A to (-)-notoamide B via the 2,3- epoxidation of (+)-stephacidin A followed by a pinacol-type rearrangement (Probable). Finally, it remains unclear which enzyme could be responsible for the final hydroxylation steps leading to notoamide A and sclerotiamide (Probable). The function of notN in the notoamide biosynthesis has not been determined yet (Probable).
catalytic activity: a primary alcohol + NAD(+) = an aldehyde + NADH + H(+) (RHEA:10736)
catalytic activity: a secondary alcohol + NAD(+) = a ketone + NADH + H(+) (RHEA:10740)
cofactor: Zn(2+) (Binds 2 Zn(2+) ions per subunit.)
CH_124303 alcohol dehydrogenase 1 from Magnaporthe grisea 70-15 (see paper)
37% identity, 100% coverage
PITG_11295 alcohol dehydrogenase, putative from Phytophthora infestans T30-4
37% identity, 94% coverage
PADG_11405 alcohol dehydrogenase 1 from Paracoccidioides brasiliensis Pb18
48% identity, 63% coverage
- Global Molecular Response of Paracoccidioides brasiliensis to Zinc Deprivation: Analyses at Transcript, Protein and MicroRNA Levels
Mesquita, Journal of fungi (Basel, Switzerland) 2023 - “...degradation. Methyclcitrate cycle was putatively activated since methylcitrate dehydratase (PADG_04718) was increased. Two alcohol dehydrogenases (PADG_11405; PADG_04701) were repressed confirming that the fungus was preferentially using the aerobic oxidation of amino acids and lipids. The decrease in zinc availability resulted in the accumulation of enzymes related...”
- Metabolic Peculiarities of Paracoccidioides brasiliensis Dimorphism as Demonstrated by iTRAQ Labeling Proteomics
Araújo, Frontiers in microbiology 2019 - “...were up-regulated in mycelium. In respect to enzymes related to alcoholic fermentation, alcohol dehydrogenase ADH1 (PADG_11405) was induced in comparison to the other two developmental stages. This fact caught our attention since it had been previously described that P. lutzii presents a more anaerobic metabolism in...”
- “...than the other phases. In addition, analysis of the level of expression of alcohol dehydrogenase (PADG_11405) from proteomic analysis confirmed that the abundance of this enzyme was significantly higher in mycelium ( Supplementary Table S3 ). Pyruvate decarboxylase (PADG_00714) is required to shunt pyruvate from glycolysis...”
- Differential Metabolism of a Two-Carbon Substrate by Members of the Paracoccidioides Genus
Baeza, Frontiers in microbiology 2017 - “...dehydrogenase (PAAG_03910) were induced in Pb 01 and Pb EPM83 and alcohol dehydrogenase (PAAG_00403; PABG_04316; PADG_11405) was induced in all studied isolates. Acetate may provide ethanol because of the increase in aldehyde dehydrogenase and alcohol dehydrogenase. A high level of enzymes involved in ethanol production was...”
Desfe_1240 zinc-dependent alcohol dehydrogenase family protein from Desulfurococcus amylolyticus DSM 16532
35% identity, 95% coverage
- Metabolic reconstruction and experimental verification of glucose utilization in Desulfurococcus amylolyticus DSM 16532
Reischl, Folia microbiologica 2018 - “...). However, the gene annotations presented here indicate that D. amylolyticus possesses an alcohol dehydrogenase (Desfe_1240) that could form D-arabino-1,4-lactone and contains a D-arabino-1 dehydrogenase, which is a homolog to the dehydrogenase found in Sulfolobus solfataricus (SSO1300). Clusters of orthologous groups (COG) from various organisms for...”
- “...very thermodynamic unfavorable reaction (Thauer et al. 1977 ), followed by alcohol dehydrogenase (Desfe_0019 and Desfe_1240) catalysis, which would form ethanol. Two NAD(P)H would be needed for these two reactions. The formation of the metabolic end product lactate would only require 1 NADH and could be...”
ADHC1_MYCS2 / P0CH36 NADP-dependent alcohol dehydrogenase C 1; Ms-ADHC 1; EC 1.1.1.2 from Mycolicibacterium smegmatis (strain ATCC 700084 / mc(2)155) (Mycobacterium smegmatis) (see 2 papers)
ADHC2_MYCS2 / P0CH37 NADP-dependent alcohol dehydrogenase C 2; Ms-ADHC 2; EC 1.1.1.2 from Mycolicibacterium smegmatis (strain ATCC 700084 / mc(2)155) (Mycobacterium smegmatis) (see 2 papers)
MSMEG_1037 alcohol dehydrogenase, zinc-containing from Mycobacterium smegmatis str. MC2 155
34% identity, 95% coverage
- function: Prefers aldehydes over alcohols
catalytic activity: a primary alcohol + NADP(+) = an aldehyde + NADPH + H(+) (RHEA:15937)
cofactor: Zn(2+) (Binds 2 Zn(2+) ions per subunit.)
disruption phenotype: Not essential for growth, strains missing one copy or both grow slower and have a different morphology than wild- type. - function: Prefers aldehydes over alcohols
catalytic activity: a primary alcohol + NADP(+) = an aldehyde + NADPH + H(+) (RHEA:15937)
cofactor: Zn(2+) (Binds 2 Zn(2+) ions per subunit.)
disruption phenotype: Not essential for growth, strains missing one copy or both grow slower and have a different morphology than wild- type. - Acid stress response of a mycobacterial proteome: insight from a gene ontology analysis
Roxas, International journal of clinical and experimental medicine 2009 (secret)
SE37_00690 zinc-dependent alcohol dehydrogenase family protein from Geobacter soli
37% identity, 98% coverage
FVEG_03423 hypothetical protein from Fusarium verticillioides 7600
39% identity, 92% coverage
LAF_1579 alcohol dehydrogenase from Lactobacillus fermentum IFO 3956
35% identity, 98% coverage
patD / A0A075TMP0 neopatulin dehydrogenase from Penicillium expansum (see paper)
PATD_PENEN / A0A075TMP0 Alcohol dehydrogenase patD; Patulin biosynthesis cluster protein D; EC 1.1.1.- from Penicillium expansum (Blue mold rot fungus) (see 8 papers)
39% identity, 100% coverage
- function: Alcohol dehydrogenase; part of the gene cluster that mediates the biosynthesis of patulin, an acetate-derived tetraketide mycotoxin produced by several fungal species that shows antimicrobial properties against several bacteria (PubMed:25625822, PubMed:30100914, PubMed:30680886). PatD catalyzes the conversion of neopatulin into E- ascladiol (PubMed:30680886). The pathway begins with the synthesis of 6-methylsalicylic acid by the polyketide synthase (PKS) patK via condensation of acetate and malonate units. The 6-methylsalicylic acid decarboxylase patG then catalyzes the decarboxylation of 6- methylsalicylic acid to yield m-cresol (also known as 3-methylphenol). These first reactions occur in the cytosol. The intermediate m-cresol is then transported into the endoplasmic reticulum where the cytochrome P450 monooxygenase patH converts it to m-hydroxybenzyl alcohol, which is further converted to gentisyl alcohol by the cytochrome P450 monooxygenase patI. The oxidoreductases patJ and patO further convert gentisyl alcohol to isoepoxydon in the vacuole. PatN catalyzes then the transformation of isoepoxydon into phyllostine. The cluster protein patF is responsible for the conversion from phyllostine to neopatulin whereas the alcohol dehydrogenase patD converts neopatulin to E- ascladiol. The steps between isoepoxydon and E-ascladiol occur in the cytosol, and E-ascladiol is probably secreted to the extracellular space by one of the cluster-specific transporters patC or patM. Finally, the secreted patulin synthase patE catalyzes the conversion of E-ascladiol to patulin (Probable) (PubMed:30680886).
catalytic activity: neopatulin + NADPH + H(+) = (E)-ascladiol + NADP(+) (RHEA:62224)
cofactor: Zn(2+) (Binds 2 Zn(2+) ions per subunit.)
disruption phenotype: Strongly reduces the production of patulin.
MT3130 NADP-dependent alcohol dehydrogenase from Mycobacterium tuberculosis CDC1551
P0A4X1 NADP-dependent alcohol dehydrogenase C from Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97)
Rv3045 PROBABLE NADP-DEPENDENT ALCOHOL DEHYDROGENASE ADHC from Mycobacterium tuberculosis H37Rv
34% identity, 96% coverage
- REMap: Operon map of M. tuberculosis based on RNA sequence data
Pelly, Tuberculosis (Edinburgh, Scotland) 2016 - “...annotations in the TubercuList database [ 33 ] ( MT3129 encodes an ATP synthase , MT3130 encodes an NADP-dependent alcohol dehydrogenase and MT3131.1 encodes a hypothetical protein), and secondly, the IGR between MT3130 and MT3131.1 contains a gene, MT3131 , in the reverse orientation ( Figure...”
- Oral vaccination with heat inactivated Mycobacterium bovis activates the complement system to protect against tuberculosis
Beltrán-Beck, PloS one 2014 - “...number) Upstream/downsteam primer sequences (5-3) PCR annealing temperature PCR product size (bp) NADP-dependent alcoholdehydrogenase C(NADPAD) (P0A4X1) GGTGGTCATATGAGCACTGTTGCCGCCTAC/GGTGGTTGCTCTTCCGCACAGGGCTGAGATGTCGATGAC 56C 1,041 glyceraldehyde-3-phosphate dehydrogenase(GAPDH) (P64179) GGTGGTCATATGGTGACGGTCCGAGTAGGCATC/GTGGTTGCTCTTCCGCAGAGCGACTTGCCGACCAGCGT 66C 1,023 MPB83 (ACD61707) GGTGGTCATATGATCAACGTTCAGGCCAAA/GGTGGTTGCTCTTCCGCACTGTGCCGGGGGCATCAGCAC 42C 663 Universal stress protein RV2623/MT2698 (NP_337200) GGTGGTCATATGTCATCGGGCAATTCATCT/GGTGGTTGCTCTTCCGCAAGTCAGCGACTCGCGTGCCAC 42C 894 In vitro Experiments In vitro infection and analysis...”
- “...DCs and macrophages [29] . Band 2 was identified as NADP-dependent alcohol dehydrogenase C (NADPAD) (P0A4X1) [30] . Band 3 contained two proteins, MPB83 (ACD61707) and the universal stress protein Rv2623/MT2698 (NP_337200). MPB83 is a secreted glycoprotein with homology to MPB70 [31] , [32] that has...”
- Devising Isolation Forest-Based Method to Investigate the sRNAome of Mycobacterium tuberculosis Using sRNA-seq Data
Maity, Bioinformatics and biology insights 2024 - “...For example, the start site of the sRNA ncRv3045 matched with an internal TSS of Rv3045 ( Figure 5 ). ncRv3045 is conserved in the genomes of M. africanum , M. canettii , M. bovis , M. avium , M. haemophilum , M. leprae , and...”
- “...). Figure 5. TSS-driven synthesis of ncRv3045. sRNA ncRv3045 is located within the CDS of Rv3045 and is detected in all the studied growth conditions except in nutrient starvation. A previously annotated internal TSS (iTSS) located immediately upstream of the ncRv3045 (indicated by the blue vertical...”
- Building a better bacillus: the emergence of Mycobacterium tuberculosis
Wang, Frontiers in microbiology 2014 - “...Rv1894c Rv1894c, Rv2172c Rv2172c, Rv2392 - cysH, Rv2440c - obg, Rv2477c Rv2477c, Rv3019c - esxR, Rv3045 - adhC, Rv3392c - cmaA1, Rv3502c - hsd4A . FIGURE 2 Genomic organization of operons in M. tuberculosis, M. kansasii , and M. marinum. (A) Rv0986-0988 ; (B) Rv3376-3378c ;...”
- Prokaryotic ubiquitin-like protein (Pup) proteome of Mycobacterium tuberculosis [corrected]
Festa, PloS one 2010 - “...LeuD (21.8) 154 Rv1185c FadD21 (62.8) 355 Rv3002c IlvN (18.2) 44 Rv1295 ThrC (37.3) 151 Rv3045 AdhC (37.1) 209 Rv1308 AtpA (59.3) 489 Rv3149 NuoE (27.2) 45 Rv1315 MurA (44.0) 81 Rv3246c MtrA (25.3) 207 Rv1392 MetK (43.0) 345 Rv3248c SahH (54.3) 474 Rv1655 ArgD (40.9)...”
- Quantification of global transcription patterns in prokaryotes using spotted microarrays
Sidders, Genome biology 2007 - “...- 95 Rv3680 Rv3680 765 294 - 96 Rv3457c rpoA 760 293 In vitro 97 Rv3045 adhC 756 272 - 98 Rv1792 Rv1792 753 326 - 99 Rv2969c Rv2969c 738 141 In vitro 100 Rv1177 fdxC 736 303 In vitro 101 Rv3867 Rv3867 735 200 -...”
GL4_0818 zinc-dependent alcohol dehydrogenase family protein from Methyloceanibacter caenitepidi
36% identity, 98% coverage
LAF_1579 zinc-dependent alcohol dehydrogenase family protein from Limosilactobacillus fermentum IFO 3956
36% identity, 95% coverage
adhA / C0SPA5 S-(hydroxymethyl)bacillithiol dehydrogenase (EC 1.1.1.306) from Bacillus subtilis (strain 168) (see 2 papers)
ADHA_BACSU / C0SPA5 Probable formaldehyde dehydrogenase AdhA; EC 1.1.1.- from Bacillus subtilis (strain 168) (see paper)
NP_390579 putative aldehyde dehydrogenase; carbonyl stress response from Bacillus subtilis subsp. subtilis str. 168
NP_390579 putative dehydrogenase from Bacillus subtilis subsp. subtilis str. 168
34% identity, 97% coverage
MAB_3400 NADP-dependent alcohol dehydrogenase C from Mycobacterium abscessus ATCC 19977
33% identity, 94% coverage
GSU0573 alcohol dehydrogenase, zinc-containing from Geobacter sulfurreducens PCA
36% identity, 98% coverage
SCO4945 dehydrogenase from Streptomyces coelicolor A3(2)
36% identity, 89% coverage
Caur_2281 zinc-binding alcohol dehydrogenase family protein from Chloroflexus aurantiacus J-10-fl
34% identity, 98% coverage
Tagg_0918 zinc-dependent alcohol dehydrogenase family protein from Thermosphaera aggregans DSM 11486
35% identity, 95% coverage
- Complete genome sequence of Thermosphaera aggregans type strain (M11TL)
Spring, Standards in genomic sciences 2010 - “...alcohol dehydrogenases. Genes of two different types of alcohol dehydrogenases were identified, a zinc binding (Tagg_0918) and an iron containing enzyme (Tagg_0471). The reduction of aldehydes leads to the oxidation of NAD(P)H, whereas the oxidation to carboxylic acids produces reduced ferredoxin, hence, a function of both...”
Minf_1850 Zn-dependent alcohol dehydrogenase from Methylacidiphilum infernorum V4
33% identity, 79% coverage
BMI_I1066 alcohol dehydrogenase, zinc-containing from Brucella microti CCM 4915
35% identity, 98% coverage
- Comparative Genome-Wide Transcriptome Analysis of Brucella suis and Brucella microti Under Acid Stress at pH 4.5: Cold Shock Protein CspA and Dps Are Associated With Acid Resistance of B. microti
de, Frontiers in microbiology 2021 - “...for intracellular growth in J774 murine macrophages. Fourteen of the mutants, affected in the genes BMI_I1066, BMI_II893, BMI_I1677, BMI_II226, BMI_II385, BMI_II460, BMI_II847, BMI_I1652, BMI_I1679, BMI_I733, BMI_I686, BMI_II580, BMI_II225, and BMI_II898, did not show any reduction in survival as compared to the wild-type strain in minimal medium...”
NP_386798 PUTATIVE ZINC-TYPE ALCOHOL DEHYDROGENASE PROTEIN from Sinorhizobium meliloti 1021
33% identity, 94% coverage
BMEI0925 ALCOHOL DEHYDROGENASE from Brucella melitensis 16M
34% identity, 98% coverage
BMD_3473 zinc-binding dehydrogenase family oxidoreductase from Bacillus megaterium DSM319
34% identity, 88% coverage
- Metabolic Rearrangements Causing Elevated Proline and Polyhydroxybutyrate Accumulation During the Osmotic Adaptation Response of Bacillus megaterium
Godard, Frontiers in bioengineering and biotechnology 2020 - “...and Supplementary Table 2 ). Finally, several oxidoreductases (BMD_0912, BMD_0989, BMD_1041, BMD_2681, BMD_3119, BMD_3139, BMD_3288, BMD_3473, BMD_3493), peptidases and proteases (BMD_0331, InhA, BMD_3039, PepQ, BMD_4817, CtpB, BMD_5202) were also part of this core group of proteins and their increased concentrations positively contributed to a reduction of...”
WR30_RS16630 zinc-dependent alcohol dehydrogenase family protein from Burkholderia contaminans FFH2055
37% identity, 95% coverage
YahK / b0325 aldehyde reductase, NADPH-dependent (EC 1.1.1.2; EC 1.1.1.55) from Escherichia coli K-12 substr. MG1655 (see 8 papers)
yahK / P75691 aldehyde reductase, NADPH-dependent (EC 1.1.1.2; EC 1.1.1.55) from Escherichia coli (strain K12) (see 7 papers)
YAHK_ECOLI / P75691 Aldehyde reductase YahK; Zinc-dependent alcohol dehydrogenase YahK; EC 1.1.1.2 from Escherichia coli (strain K12) (see 2 papers)
yahK / MB|P75691 zinc-type alcohol dehydrogenase-like protein yahK from Escherichia coli K12 (see paper)
NP_414859 aldehyde reductase, NADPH-dependent from Escherichia coli str. K-12 substr. MG1655
b0325 predicted oxidoreductase, Zn-dependent and NAD(P)-binding from Escherichia coli str. K-12 substr. MG1655
B21_00284 NADPH-dependent aldehyde reductase YahK from Escherichia coli BL21(DE3)
35% identity, 96% coverage
- function: Catalyzes the reduction of a wide range of aldehydes into their corresponding alcohols. Has a strong preference for NADPH over NADH as the electron donor. Cannot use a ketone as substrate. Is a major source of NADPH-dependent aldehyde reductase activity in E.coli. The in vivo functions of YahK has yet to be determined.
catalytic activity: a primary alcohol + NADP(+) = an aldehyde + NADPH + H(+) (RHEA:15937)
cofactor: Zn(2+) (Binds 2 Zn(2+) ions per subunit. {ECO:0000269|PubMed:22094925, ECO:0000269|Ref.)6} - Detection of immunoreactive proteins of Escherichia coli, Streptococcus uberis, and Streptococcus agalactiae isolated from cows with diagnosed mastitis
Dobrut, Frontiers in cellular and infection microbiology 2023 - “...cofactor biosynthesis protein B P0AF00 18768 Cymiddlelasm Other N N Antigen EC_2 Aldehyde reductase YahK P75691 38524 Cymiddlelasm Other N N Antigen EC_3 Outer membrane protein A P0A911 37292 Outer membrane Sec signal peptide predicted. Most likely cleavage site: 1 - 21 [AQA-AP] Y Y Antigen...”
- “...cofactor biosynthesis protein B P0AF00 7 1r2k.1.A 100% 0.96 3 3 EC_2 Aldehyde reductase YahK P75691 13 1uuf.1.A 99.7% 0.95 5 6 EC_3 Outer membrane protein A P0A911 12 3nb3.1.A 99.4% 0.39 3 5 GMQE, Global Model Quality Estimation, calculated after building the model on selected...”
- Early and specific targeted mass spectrometry-based identification of bacteria in endotracheal aspirates of patients suspected with ventilator-associated pneumonia
Bardet, European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology 2021 - “...time: 20.44min); GQAINVQNIYGK (D0C807 UniProtKB accession number; retention time: 15.56min). * 2 E. coli VVAVGDQVEK: (P75691 UniProtKB accession number; retention time: 11.24min); DYVEGETAAK (P0A9Q7 UniProtKB accession number; retention time: 9.76min); WNGVTVTPK (P0ADU5 UniProtKB accession number; retention time: 13.99min). * 3 H. influenzae : YAYVTLGNK (P43839 UniProtKB...”
- Combinatorial modulation of initial codons for improved zeaxanthin synthetic pathway efficiency in Escherichia coli
Wu, MicrobiologyOpen 2019 - “...5phosphate synthase OS= Escherichia coli (strain K12) 38.62064587 16.0494 5 243 26.368 5.95 1.276 25.20745921 P75691 Aldehyde reductase YahK OS= Escherichia coli (strain K12) 35.94943889 14.3266 6 349 37.954 6.23 0.995 24.27691317 P0AB77 2amino3ketobutyrate coenzyme A ligase OS= Escherichia coli 23.08778624 9.79899 4 398 43.09 5.97...”
- “...5phosphate synthase OS= Escherichia coli (strain K12) 65.53282216 16.4609 7 243 26.368 5.95 2.162 39.8662715 P75691 Aldehyde reductase YahK OS= Escherichia coli (strain K12) 57.03702369 23.7822 10 349 37.954 6.23 1.512 45.17795205 P0AB77 2amino3ketobutyrate coenzyme A ligase OS= Escherichia coli 46.90887079 20.603 8 398 43.09 5.97...”
- Energetics-based protein profiling on a proteomic scale: identification of proteins resistant to proteolysis
Park, Journal of molecular biology 2007 - “...agp 391 43.6 5.38 10 P37095 pepB 427 46.2 5.60 11 a P75691 yahK 349 38.0 5.80 12 P00509 aspC 396 43.6 5.54 13 P11665 Pgk 386 41.0 5.08 14 P02928 malE 370 40.7...”
- The Escherichia coli proteome: past, present, and future prospects
Han, Microbiology and molecular biology reviews : MMBR 2006 - “...YaeC YaeH YaeT P37016 P0ACC3 Q9F577 P62768 P0A940 YahK P75691 YajD YajG YajO YajQ YbbL P0AAQ2 P0ADA5 P77735 P0A8E7 P77279 YbbN YbdQ P77395 YbeZ YbfF P0A9K3...”
- Escherichia coli alcohol dehydrogenase YahK is a protein that binds both iron and zinc.
Liang, PeerJ 2024 - GeneRIF: Escherichia coli alcohol dehydrogenase YahK is a protein that binds both iron and zinc.
- Sxy induces a CRP-S regulon in Escherichia coli
Sinha, Journal of bacteriology 2009 - “...77 78 79 79 b3863 b0294 b3334 b0245 b4326 b1562 b0235 b0325 b3554 b4327 b0032 b2821 b2819 polA matA gspM ykfI yjiD hokD ykfJ yahK yiaF yjiE carA ptrA recD 4.18...”
- Reconfiguring the quorum-sensing regulator SdiA of Escherichia coli to control biofilm formation via indole and N-acylhomoserine lactones
Lee, Applied and environmental microbiology 2009 - “...RNA affecting ompF expression Hypothetical yahK yahO ybaS b0325 b0329 b0485 5.7 7.0 7.5 2.6 2.8 2.3 Hypothetical zinc-type alcohol dehydrogenase-like protein...”
- Definition of the Escherichia coli MC4100 genome by use of a DNA array
Peters, Journal of bacteriology 2003 - “...yagC, yagE, yagT, ykfD,a b0331, b0333 eaeH b0323, b0324, b0325, b0350a yagA, yagB, yagJ, yagK, yagP, yagQ, yagR, yagS, yagU, yagV, yagX, yagY, yagZ, yahA, ycfA,...”
- Modular assembly of an artificially concise biocatalytic cascade for the manufacture of phenethylisoquinoline alkaloids
Gao, Nature communications 2024 - “..., accession number: B21_00205 ; yeaE , accession number: B21_01738 ; yahK , accession number: B21_00284 ; yjgB , accession number: B21_04099 and yqhC , accession number: B21_02833 ) were obtained from online software ( https://www.atum.bio/eCommerce/cas9/input ) and ligated to the plasmid pTargetF (Addgene), giving the...”
A5VLQ6 Alcohol dehydrogenase, zinc-binding type 2 from Limosilactobacillus reuteri (strain DSM 20016)
34% identity, 98% coverage
- Redox Balance in Lactobacillus reuteri DSM20016: Roles of Iron-Dependent Alcohol Dehydrogenases in Glucose/ Glycerol Metabolism
Chen, PloS one 2016 - “...- - - 8 A5VLU6 Alcohol dehydrogenase (ADH3) lreu_1578 368 39107 - - - 8 A5VLQ6 Alcohol dehydrogenase (ADH4) lreu_1535 348 37899 - - - 8 A5VLL8 Alcohol dehydrogenase (ADH5) lreu_1496 342 36124 -0.87 -2.22 -2.95 8 A5VIB7 Alcohol dehydrogenase (ADH6) lreu_0321 878 97189 -2.01 -6.18...”
- “...Supporting Information S1 Fig Amino acid alignment of ADH1 (A5VMM4), ADH2 (A5VM35), ADH3 (A5VLU6), ADH4 (A5VLQ6), ADH5 (A5VLL8) and ADH8 (A5VLV6) from L . reuteri DSM20016. Red circle, putative catalytic residues; green circle, putative coenzyme binding motif; blue circle, the residues for the coordination of structural...”
Saci_2057 alcohol dehydrogenase from Sulfolobus acidocaldarius DSM 639
35% identity, 98% coverage
Z0420 putative oxidoreductase from Escherichia coli O157:H7 EDL933
35% identity, 96% coverage
- Activated peritoneal cavity B-1a cells possess regulatory B cell properties
Margry, PloS one 2014 - “...assay (ELISA). 96-well ELISA plates (NUNC Maxisorp) were coated with polyclonal goat anti-mouse immunoglobulins (Dako Z0420). Free binding sites were blocked with a blocking buffer containing 4% horse serum (Gibco) and 1% Tween-80 (Sigma). Sera were diluted in a buffer containing 4% horse serum, 1% Tween-80...”
A1R6C3 alcohol dehydrogenase (NADP+) (EC 1.1.1.2) from Paenarthrobacter aurescens (see paper)
AAur_2040 NADP-dependent alcohol dehydrogenase from Arthrobacter aurescens TC1
34% identity, 95% coverage
- Defining lower limits of biodegradation: atrazine degradation regulated by mass transfer and maintenance demand in Arthrobacter aurescens TC1
Kundu, The ISME journal 2019 - “...1.61 0.018 0.82 0.223 A1R7Y1 AAur_2625 Alcohol dehydrogenase 0.55 0.222 0.08 0.849 0.47 0.433 A1R6C3 AAur_2040 Alcohol dehydrogenase 1.76 0.085 1.47 0.104 0.29 0.846 2 A1RDQ5 AAur_pTC20218 Putative alcohol dehydrogenase 2.07 0.007 1.25 0.038 0.82 0.264 A1R953 AAur_3064 Aldehyde dehydrogenase (NAD) 1.93 0.006 2.76 0.005 0.83...”
- Degradation of Swainsonine by the NADP-Dependent Alcohol Dehydrogenase A1R6C3 in Arthrobacter sp. HW08
Wang, Toxins 2016 - “...with or without SW stimulation. Using this assay, we demonstrated that the NADP-dependent alcohol dehydrogenase AAur_2040 played a dominant role in SW degradation. 2. Results 2.1. Degradation of SW by Strain HW08 The strain HW08 was previously isolated and was shown to have the capacity to...”
- “...protein quantification results based on iBAQ intensity ( Figure 4 B). Of note, AAur_1890 , AAur_2040 , and Arth_2986 , which encode A1R5X7, A1R6C3, and A0JZ95, were the most significantly upregulated genes in strain HW08 cells following SW induction ( Figure 4 A,B). Then, we focused...”
- Defining lower limits of biodegradation: atrazine degradation regulated by mass transfer and maintenance demand in Arthrobacter aurescens TC1.
Kundu, The ISME journal 2019 - “...0.132 1.61 0.018 0.82 0.223 A1R7Y1 AAur_2625 Alcohol dehydrogenase 0.55 0.222 0.08 0.849 0.47 0.433 A1R6C3 AAur_2040 Alcohol dehydrogenase 1.76 0.085 1.47 0.104 0.29 0.846 2 A1RDQ5 AAur_pTC20218 Putative alcohol dehydrogenase 2.07 0.007 1.25 0.038 0.82 0.264 A1R953 AAur_3064 Aldehyde dehydrogenase (NAD) 1.93 0.006 2.76 0.005...”
- Degradation of Swainsonine by the NADP-Dependent Alcohol Dehydrogenase A1R6C3 in Arthrobacter sp. HW08.
Wang, Toxins 2016 - “...Toxins 2072-6651 MDPI 4885060 10.3390/toxins8050145 toxins-08-00145 Article Degradation of Swainsonine by the NADP-Dependent Alcohol Dehydrogenase A1R6C3 in Arthrobacter sp. HW08 Wang Yan 1 * Zhai Aguan 1 Zhang Yanqi 1 Qiu Kai 2 Wang Jianhua 1 Li Qinfan 1 * Shaw Pang-Chui Academic Editor 1 College...”
- “...sugar phosphate isomerase/epimerase A1R5X7, Acetyl-CoA acetyltransferase A0JZ95, and nicotinamide adenine dinucleotide phosphate (NADP)-dependent alcohol dehydrogenase A1R6C3 were found to contribute to the swainsonine degradation. Notably, NADP-dependent alcohol dehyrodgenase A1R6C3 appeared to play a major role in degrading swainsonine, but not as much as Arthrobacter sp. HW08...”
A0A125SUY5 alcohol dehydrogenase (NADP+) (EC 1.1.1.2) from Mycobacterium sp. (see paper)
31% identity, 97% coverage
L2164_13090 NAD(P)-dependent alcohol dehydrogenase from Pectobacterium brasiliense
35% identity, 95% coverage
APA386B_2362 zinc-dependent alcohol dehydrogenase family protein from Acetobacter pasteurianus 386B
35% identity, 98% coverage
- Complete genome sequence and comparative analysis of Acetobacter pasteurianus 386B, a strain well-adapted to the cocoa bean fermentation ecosystem
Illeghems, BMC genomics 2013 - “...APA386B_2736); (32) dihydrolipoamide dehydrogenase (APA386B_2735 and APA386B_2271); (33) pyruvate decarboxylase (APA386B_1186); (34) alcohol dehydrogenase (APA386B_1507, APA386B_2362, and APA386B_496); (35) aldehyde dehydrogenase (APA386B_909); (36) acetyl-CoA synthetase (APA386B_1843 and APA386B_2214); (37) acetate kinase (APA386B_335); (38) phosphate acetyltransferase (APA386B_336); (39) malate dehydrogenase (APA386B_1600); (40) aconitate hydratase 1 (APA386B_1323); (41)...”
- “...region: 307329), APA386B_2052 (transmembrane region: 931), APA386B_767 (transmembrane region: 36102), APA386B_1507 (transmembrane region: 168188), and APA386B_2362 (transmembrane regions: 164184, 222242)]; (7) succinate dehydrogenase/fumarate reductase (APA386B_1513 - APA386B_1516); (8) cytochrome bo 3 ubiquinol oxidase (APA386B_1578 - APA386B_1581); (9) cytochrome bd ubiquinol oxidase (APA386B_472 - APA386B_473 and APA386B_1010-APA386B_1011)....”
BPSS1918 putative alcohol dehydrogenase from Burkholderia pseudomallei K96243
BMAA0163 alcohol dehydrogenase, zinc-containing from Burkholderia mallei ATCC 23344
34% identity, 98% coverage
blr6070 blr6070 from Bradyrhizobium japonicum USDA 110
36% identity, 98% coverage
- Reconstruction of the core and extended regulons of global transcription factors
Dufour, PLoS genetics 2010 - “...direct FnrL targets under the conditions tested. For the B. japonicum FixK regulon, expression of blr6070, blr6071, blr4637, blr0497 and blr6074 (ID 3100, 2589, 1551, 5478 and 2256) was shown to depend on FixK 2 (a FixK-type regulator) [8] , [42] , as we predicted. We...”
- Posttranslational control of transcription factor FixK2, a key regulator for the Bradyrhizobium japonicum-soybean symbiosis
Mesa, Proceedings of the National Academy of Sciences of the United States of America 2009 - “...name blr2763 blr2767 blr6062 bll7086 bll3998 blr4655 bll6073 blr6070 bll6061 blr4637 bsr7087 fixN fixG cycS hemN2 ppsA phbC fixK1 WT treated vs. untreated (H2O2...”
- Comprehensive assessment of the regulons controlled by the FixLJ-FixK2-FixK1 cascade in Bradyrhizobium japonicum
Mesa, Journal of bacteriology 2008 - “...promoter on 409-bp XbaI-SpeI fragment Apr (pRJ9519) blr6070 promoter on 455-bp BamHI-EcoRI fragment Apr (pRJ9519) bsr7087 promoter on 316-bp BamHI-EcoRI...”
- “...b561 Unknown protein bsr5273 bll5315 bsr5316 bll5655 bll6061 bll6069 blr6070 bll6073 blr6074 blr6128 102.6 34.4 22.5 36.2 19.1 29.4 7.3 27.9 90.9 16.0 68.5 10.2...”
GOX0314 Probable alcohol dehydrogenase-like oxidoreductase protein from Gluconobacter oxydans 621H
35% identity, 98% coverage
- Characterization of Two Dehydrogenases from Gluconobacter oxydans Involved in the Transformation of Patulin to Ascladiol
Chan, Toxins 2022 - “...dependent. Therefore, the predicted NADP(H) dependent dehydrogenases/reductase selected as possible candidates for patulin transformation were GOX0314 (AAW60097.1), GOX0716 (AAW60493.1), GOX1462 (AAW61211.1), GOX1615 (AAW61356.1), and GOX1899 (AAW61637.1). 2.3. Analysis of Ascladiol Formation by Whole Recombinant E. coli Cells Genes encoding putative patulin transforming enzymes (GOX0525, GOX0314, GOX0716,...”
- “...GOX0716 ( Figure 5 ). No detectable E-ascladiol was observed for E. coli strains producing GOX0314 and GOX1615. 2.4. Purification of Recombinant Enzymes That Transform Patulin to E-Ascladiol Attempts to purify GOX1462 from recombinant E. coli resulted in protein aggregation while GOX0716 was previously reported to...”
- FNR-Type Regulator GoxR of the Obligatorily Aerobic Acetic Acid Bacterium Gluconobacter oxydans Affects Expression of Genes Involved in Respiration and Redox Metabolism
Schweikert, Applied and environmental microbiology 2021 - “...GoxR. The pnt operon encodes a transhydrogenase (pntA1A2B), an NADH-dependent oxidoreductase (GOX0313), and another oxidoreductase (GOX0314). Evidence was obtained for GoxR being active despite a high dissolved oxygen concentration in the medium. We suggest a model in which the very high respiration rates of G. oxydans...”
- Combined fluxomics and transcriptomics analysis of glucose catabolism via a partially cyclic pentose phosphate pathway in Gluconobacter oxydans 621H
Hanke, Applied and environmental microbiology 2013 - “...oxidation (35). The genes downstream of pntB, GOX0313 and GOX0314, showed comparable mRNA ratios (5.5 and 4.8) as the pntA1A2B genes, suggesting that these five...”
- “...energy metabolism GOX1857 GOX0310 GOX0311 GOX0312 GOX0313 GOX0314 GOX2087 GOX2088 GOX2089 GOX2090 GOX2167 GOX2168 GOX2169 GOX2170 GOX2171 GOX2172 GOX2173...”
- Mutational analysis of the pentose phosphate and Entner-Doudoroff pathways in Gluconobacter oxydans reveals improved growth of a Δedd Δeda mutant on mannitol
Richhardt, Applied and environmental microbiology 2012 - “...upp gnd zwf* upp edd eda GOX0310 GOX0311 GOX0312 GOX0313 GOX0314 2.09 2.13 2.26 2.23 1.60 3.39 3.22 2.92 2.93 2.11 NR NR NR NR NR Metabolism Carbonic anhydrase...”
- “...and two dehydrogenases showed increased expression (GOX0310 to GOX0314, mRNA ratios of 2.1 to 1.6 and 3.4 to 2.1, respectively). (ii) Genes involved in...”
all0879 alcohol dehydrogenase from Nostoc sp. PCC 7120
33% identity, 98% coverage
BPSL0192 NADP-dependent alcohol dehydrogenase from Burkholderia pseudomallei K96243
34% identity, 87% coverage
chnD / Q9F7D8 6-hydroxyhexanoate dehydrogenase (EC 1.1.1.258) from Acinetobacter sp. (strain SE19) (see paper)
36% identity, 95% coverage
BMULJ_05620 alcohol dehydrogenase from Burkholderia multivorans ATCC 17616
36% identity, 94% coverage
AO090003001407 No description from Aspergillus oryzae RIB40
33% identity, 93% coverage
vnz_22770 NAD(P)-dependent alcohol dehydrogenase from Streptomyces venezuelae
33% identity, 92% coverage
ssr / A4YGN0 succinate semialdehyde reductase monomer from Metallosphaera sedula (strain ATCC 51363 / DSM 5348 / JCM 9185 / NBRC 15509 / TH2) (see 2 papers)
SUCD_METS5 / A4YGN0 Succinate-semialdehyde dehydrogenase (acetylating); EC 1.2.1.76 from Metallosphaera sedula (strain ATCC 51363 / DSM 5348 / JCM 9185 / NBRC 15509 / TH2) (see paper)
Msed_1424 Alcohol dehydrogenase, zinc-binding domain protein from Metallosphaera sedula DSM 5348
34% identity, 91% coverage
- function: Catalyzes the reduction of succinate semialdehyde to succinyl-CoA. The enzyme is specific for succinate semialdehyde and succinyl-CoA, and only shows low activity with palmitoyl-CoA. There is no activity with NAD(+) as cosubstrate. Participates in the 3- hydroxypropanoate/4-hydroxybutyrate cycle, an autotrophic CO(2) fixation pathway found in some thermoacidophilic archaea.
catalytic activity: succinate semialdehyde + NADP(+) + CoA = succinyl-CoA + NADPH + H(+) (RHEA:26450)
cofactor: Zn(2+) (Binds 2 Zn(2+) ions per subunit.) - Forward genetic screens identify a role for the mitochondrial HER2 in E-2-hexenal responsiveness
Scala, Plant molecular biology 2017 - “...protein with a confirmed activity. This is a succinic semi aldehyde (SSA) dehydrogenase acetylating enzyme (A4YGN0, SSADH-Acetylating, EC 1.2.1.76) of a thermo-acidophile bacterium, Metallosphaera sedula (Berg et al. 2007 ), which has 42% aa identity with HER2 (Fig. S3). The reaction catalyzed by this enzyme is...”
- “...acid sequences of the A. thaliana ADH family, AtGLYR1 and AtGLYR2, HER2 (blue) and SSADH-Acetylating A4YGN0 from M. sedula (green). ADH, BADH, betaine-aldehyde dehydrogenase; GAPN, non-phosphorylating glyceraldehyde-3-phosphate dehydrogenase; MMSA, methylmalonyl semialdehyde dehydrogenase; P5CDH, D1-pyrroline-5-carboxylate dehydrogenase; SSADH, succinic semialdehyde dehydrogenase; GLYR, glyoxylate reductase; SSADH-AC, succinic semialdehyde dehydrogenase...”
- Genome analysis of the thermoacidophilic archaeon Acidianus copahuensis focusing on the metabolisms associated to biomining activities
Urbieta, BMC genomics 2017 - “...A4YIE3 155 EZQ04694 138 8.00E -75 78 + (39) Methylmalonyl-CoA mutase (coenzyme B12-binding subunit) ssr A4YGN0 360 EZQ01731 360 0 77 + (41) Succinate semialdehyde reductase hbcS1 A4YDR9 549 - - - - - 4-Hydroxybutyryl-CoA synthetase hbcS2 A4YDT1 564 EZQ11368 559 0 58 - 4-Hydroxybutyryl-CoA synthetase...”
- Construction of a synthetic metabolic pathway for biosynthesis of the non-natural methionine precursor 2,4-dihydroxybutyric acid
Walther, Nature communications 2017 - “...semialdehyde dehydrogenase from Metallosphaera sedula (Ms-Ssr) was built from its amino-acid sequence (UniProtKB accession number A4YGN0) and the homologous ( ADH1 ) horse liver alcohol dehydrogenase (PDB code 1axe) template structure of the F93W mutant complexed with NAD + and the inhibitor trifluoroethanol using the I-TASSER...”
- Enzymes Catalyzing Crotonyl-CoA Conversion to Acetoacetyl-CoA During the Autotrophic CO2 Fixation in Metallosphaera sedula
Liu, Frontiers in microbiology 2020 - “...Msed_0709 Msed_0709 1.0 /40 f,g Up 1.3 Kockelkorn and Fuchs, 2009 Succinic semialdehyde reductase (11) Msed_1424 Msed_1424 5.0 /700 f,g /683 f,g Up 0.4 Kockelkorn and Fuchs, 2009 ; Loder et al., 2016 4-Hydroxybutyryl-CoA synthetase (12) Msed_1422 Msed_0406 0.3 ND j /1.7 f,h Up No 12.5...”
- “..., CoA ligase. (B) msed_1422 , putative 4-hydroxybutyryl-CoA synthetase; msed_1423 , ( S )-3-hydroxybutyryl-CoA dehydrogenase; msed_1424 , succinic semialdehyde reductase; msed_1425 , unknown protein; msed_1426 , acryloyl-CoA reductase. Crotonyl-CoA Hydratases Msed_0336 and Msed_0384 The purified recombinant Msed_0336 and Msed_0384 catalyzed the hydration of crotonyl-CoA to (...”
- Reaction kinetic analysis of the 3-hydroxypropionate/4-hydroxybutyrate CO2 fixation cycle in extremely thermoacidophilic archaea
Loder, Metabolic engineering 2016 - “...MCR, and SSR The genes hpcs (Msed_1456), hpcd (Msed_2001), acr (Msed_1426), mcr (Msed_0709), and ssr (Msed_1424) were amplified from genomic DNA using the primers listed in Supplementary Table S1 . The genes hpcs, acr and ssr were ligated into pET46 Ek/LIC, pRSF-2 Ek/LIC, and pET46 Ek/LIC,...”
- “...were tried. In the M. sedula genome, the genes for ACR and SSR (Msed_1426 and Msed_1424) are clustered together, separated by a single gene (Msed_1425). In an attempt to obtain soluble, active enzymes, Msed_1426 and Msed_1424 were ligated into pET46 and pRSF, respectively, and co-expressed in...”
- Novel Transcriptional Regulons for Autotrophic Cycle Genes in Crenarchaeota
Leyn, Journal of bacteriology 2015 - “...Msed_1456 Msed_1426 Msed_0639 Msed_0638 Msed_2055 Msed_1424 Msed_1422 Msed_1321 Msed_0656 Msed_1423 Msed_0363- Msed_0364 Msed_0743 ST2485 Msed_0773 Saci_2250-...”
- Conversion of 4-hydroxybutyrate to acetyl coenzyme A and its anapleurosis in the Metallosphaera sedula 3-hydroxypropionate/4-hydroxybutyrate carbon fixation pathway
Hawkins, Applied and environmental microbiology 2014 - “...Msed_1993 Msed_1456 Msed_2001 Msed_1426 Msed_0639 Msed_0638, Msed_2055 Msed_1424 Msed_0406 Msed_1321 Msed_0399 Msed_0656 NCE (6, 34) R (35, 36) R (36) NP...”
- Role of 4-hydroxybutyrate-CoA synthetase in the CO2 fixation cycle in thermoacidophilic archaea
Hawkins, The Journal of biological chemistry 2013 - “...Msed_2001 Msed_1426 Msed_0639 Msed_0638 Msed_2055 Msed_1424 Msed_0394 Msed_0406 Msed_1321 Msed_0399 Msed_0656 CO2-H2 Autotrophy in Metallosphaera sedula...”
- Epimerase (Msed_0639) and mutase (Msed_0638 and Msed_2055) convert (S)-methylmalonyl-coenzyme A (CoA) to succinyl-CoA in the Metallosphaera sedula 3-hydroxypropionate/4-hydroxybutyrate cycle
Han, Applied and environmental microbiology 2012 - “...13 14, 15 SSR HBCS HBCD CCH Msed_1424 Unknown Msed_1321 Msed_0399 16 ACK Msed_0656 Malonyl-CoA/succinyl-CoA reductase Malonate semialdehyde reductase...”
- Identification of missing genes and enzymes for autotrophic carbon fixation in crenarchaeota
Ramos-Vera, Journal of bacteriology 2011 - “...Igni_?); 11, succinic semialdehyde reductase (NADPH) (Msed_1424, Tneu_0419, Igni_?); 12, 4-hydroxybutyrate-CoA ligase (AMP forming) (Msed_?, Tneu_0420, Igni...”
- “...and similarity) to M. sedula succinic semialdehyde reductase (Msed_1424). The gene (ssr; Tneu_0419), coding for a 38-kDa protein, was overexpressed as soluble,...”
- Malonic semialdehyde reductase, succinic semialdehyde reductase, and succinyl-coenzyme A reductase from Metallosphaera sedula: enzymes of the autotrophic 3-hydroxypropionate/4-hydroxybutyrate cycle in Sulfolobales
Kockelkorn, Journal of bacteriology 2009 - “...alcohol dehydrogenase gene encoding a 37.9kDa protein (Msed_1424; 360 amino acids). Heterologous expression of succinic semialdehyde reductase from M. sedula in...”
- “...the recombinant enzyme. The succinic semialdehyde reductase gene Msed_1424 was expressed in E. coli Rosetta 2(DE3). The overproduced enzyme was purified using...”
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W8VSK8 alcohol dehydrogenase (EC 1.1.1.1); diacetyl reductase [(S)-acetoin forming] (EC 1.1.1.304); (S,S)-butanediol dehydrogenase (EC 1.1.1.76) from Mycobacterium sp. (see paper)
35% identity, 98% coverage
1uufA / P75691 Crystal structure of a zinc-type alcohol dehydrogenase-like protein yahk
34% identity, 98% coverage
CNAG_06035 alcohol dehydrogenase from Cryptococcus neoformans var. grubii H99
31% identity, 97% coverage
- Pleiotropic effects of deubiquitinating enzyme Ubp5 on growth and pathogenesis of Cryptococcus neoformans
Fang, PloS one 2012 - “...annotation * Carbohydrate/amino acid metabolism CNAG_00269 1.80 8.30E-09 Sorbitol dehydrogenase CNC05840 1.50 4.60E-07 Glycosyl hydrolase CNAG_06035 1.49 2.00E-08 Alcohol dehydrogenase CNC01140 1.38 3.00E-10 Lipase CNB00370 1.29 1.80E-07 Fatty acid beta-oxidation-related protein CNE01100 0.71 1.50E-09 long-chain-fatty-acid-CoA ligase CND00530 0.72 8.90E-07 Urea transporter CNC06440 0.70 4.80E-08 Inositol-3-phosphate synthase...”
NCgl0324 furfural detoxificationalcohol dehydrogenase FudC from Corynebacterium glutamicum ATCC 13032
cg0400 alcohol dehydrogenase, class C from Corynebacterium glutamicum ATCC 13032
33% identity, 92% coverage
- Vanillin production by Corynebacterium glutamicum using heterologous aromatic carboxylic acid reductases
Matsuzawa, Biotechnology for biofuels and bioproducts 2024 - “...glutamicum as the host owing to its high vanillin resistance. The aromatic aldehyde reductase gene (NCgl0324) and vanillic acid demethylase protein subunits A and B gene ( vanAB , NCgl2300-NCgl2301) were deleted in C. glutamicum genome to avoid vanillin degradation. Next, we searched for an aromatic...”
- “...from 4-hydroxybenzoate using Corynebacterium glutamicum [ 8 ] . They showed that the deletion of NCgl0324 in C. glutamicum decreased vanillyl alcohol production to 27% of that of the parent strain but did not reach 0%. In addition, more PC aldehydes were produced than vanillic acid...”
- Genetic Engineering Approaches for the Microbial Production of Vanillin
Santos, Biomolecules 2024 - “...Figure 13 (A4)). Vanillin could only be produced when the genes vdh , vanAB, and NCgl0324 (encoding a putative aromatic aldehyde reductase) were also deleted to prevent vanillin degradation [ 111 ]. Recently, Mo and Yuan [ 112 ] explored, in a S. cerevisiae MARE strain,...”
- “...gdh1 glutamate dehydrogenase I; gpp1 glycerol-1-phosphatese; MAREmultiple-aldehyde reductases; metJ transcription regulator of methionine biosynthetic cluster; NCgl0324 aromatic aldehyde reductase; pcaHG protocatechuate dioxygenase; pdc1 pyruvate decarboxylase; serA phosphoglycerate dehydrogenase; RAREmultiple-aldehyde reductases; trpE anthranilate synthase; csm chorismate mutase; vdh vanillin dehydrogenase; vanAB vanillate demethylase. List of endogenous genes...”
- Minimal aromatic aldehyde reduction (MARE) yeast platform for engineering vanillin production
Mo, Biotechnology for biofuels and bioproducts 2024 - “...[ 18 ]. Jin-Ho Lee et al . identified that a single gene knockout of NCgl0324 in Corynebacterium glutamicum could substantially improve the production of protocatechualdehyde (PCAL) and vanillin [ 19 ]. High-level vanillin production not only requires a reduced aldehyde reduction, but also an optimal...”
- Strategies for improving the production of bio-based vanillin
Liu, Microbial cell factories 2023 - “...the genes encoding them. To this end, genome mining was conducted in Corynebacterium glutamicum and NCgl0324 was characterized as the enzyme with aromatic aldehyde reductase activity [ 32 ]. Knocking out the corresponding gene led to a titer of 0.31g/L vanillin in the recombinant chassis. Similarly,...”
- Engineered Corynebacterium glutamicum as the Platform for the Production of Aromatic Aldehydes
Kim, Frontiers in bioengineering and biotechnology 2022 - “...that were used in comprehensive screening with a 4-hydroxybenzyl (4-HB) alcoholproducing strain. We identified that NCgl0324 has aromatic aldehyde reductase activity and contributed to 4-HB aldehyde reduction in vivo since the NCgl0324 deletion strain HB- 0324 produced 1.36g/L of 4-HB aldehyde, that is, about 188% more...”
- “...strain that produces protocatechuate was engineered from 4-hydroxybenzoate-synthesizing C. glutamicum APS963, followed by deletion of NCgl0324 to generate PV- 0324 . The PC aldehyde/alcohol or vanillin/vanillyl alcohol biosynthetic pathways, respectively, were able to be expanded from protocatechuate upon introduction of carboxylic acid reductase (CAR) and catechol...”
- High-yield production of L-serine through a novel identified exporter combined with synthetic pathway in Corynebacterium glutamicum
Zhang, Microbial cell factories 2020 - “...ABC transporter permease NCgl2942 283.52 1776.15 6.26 NADH:flavin oxidoreductase NCgl0166 13.41 79.70 5.94 Hypothetical protein NCgl0324 2.11 11.87 5.61 Zn-dependent alcohol dehydrogenase NCgl0282 5.19 28.25 5.44 4-Hydroxyphenyl-beta-ketoacyl-CoA hydrolase NCgl1975 102.94 503.75 4.89 Hypothetical protein NCgl2893 1.25 6.08 4.84 Efflux system protein NCgl0155 9.11 43.69 4.79 5-Dehydro-2-deoxygluconokinase...”
- Utilization of orange peel waste for sustainable amino acid production by Corynebacterium glutamicum
Junker, Frontiers in bioengineering and biotechnology 2024 - “...the medium. One NADPH-specific dehydrogenase contributing to furfural detoxification was identified to be encoded by cg0400 (designated as fudC ) ( Tsuge et al., 2016 ); however, crude extract of the deletion strain still had furfural dehydrogenase activity under both NADPH and NADH consumption. C. glutamicum...”
- C1 metabolism in Corynebacterium glutamicum: an endogenous pathway for oxidation of methanol to carbon dioxide
Witthoff, Applied and environmental microbiology 2013 - “...the genome of C. glutamicum (43): cg0273, cg0387 (adhE), cg0400 (adhC), and cg2714. Their expression levels were not altered in the presence of methanol. To...”
- The alcohol dehydrogenase gene adhA in Corynebacterium glutamicum is subject to carbon catabolite repression
Arndt, Journal of bacteriology 2007 - “...cells of C. glutamicum (3). Five genes (cg0273, cg0387, cg0400, cg2714, and cg3107) were annotated as potential ADH genes in the genome of C. glutamicum...”
- “...Pseudomonas aeruginosa. The other four proteins (Cg0273, Cg0387, Cg0400, and Cg2714) showed less similarity (40%) to all these ADHs. Therefore, cg3107 was...”
T1WVG5 cinnamyl-alcohol dehydrogenase (EC 1.1.1.195) from Populus tomentosa (see paper)
33% identity, 87% coverage
Ta0841 alcohol dehydrogenase related protein from Thermoplasma acidophilum DSM 1728
34% identity, 98% coverage
BCAM0286 putative alcohol dehydrogenase from Burkholderia cenocepacia J2315
35% identity, 94% coverage
Atu2022 NADP-dependent alcohol dehydrogenase from Agrobacterium tumefaciens str. C58 (Cereon)
32% identity, 90% coverage
D0C713 GroES-like protein from Acinetobacter baumannii (strain ATCC 19606 / DSM 30007 / JCM 6841 / CCUG 19606 / CIP 70.34 / NBRC 109757 / NCIMB 12457 / NCTC 12156 / 81)
32% identity, 93% coverage
F9VMI9 alcohol dehydrogenase (EC 1.1.1.1) from Sulfurisphaera tokodaii (see paper)
WP_010977990 NAD(P)-dependent alcohol dehydrogenase from Sulfurisphaera tokodaii
ST0053 344aa long hypothetical alcohol dehydrogenase from Sulfolobus tokodaii str. 7
34% identity, 97% coverage
- Sulfolobus tokodaii ST0053 produces a novel thermostable, NAD-dependent medium-chain alcohol dehydrogenase.
Yanai, Applied and environmental microbiology 2009 - GeneRIF: The purified enzyme was an NAD-dependent medium-chain alcohol dehydrogenase with high thermostability and tolerance of a wide range of pHs.
- Sulfolobus tokodaii ST0053 produces a novel thermostable, NAD-dependent medium-chain alcohol dehydrogenase
Yanai, Applied and environmental microbiology 2009 - “...Reserved. Vol. 75, No. 6 Sulfolobus tokodaii ST0053 Produces a Novel Thermostable, NAD-Dependent Medium-Chain Alcohol Dehydrogenase Hisaaki Yanai, Katsumi Doi,...”
- “...4 January 2009 An alcohol dehydrogenase (ADH) gene, ST0053, from Sulfolobus tokodaii was expressed in Escherichia coli. The purified recombinant enzyme was an...”
MSMEG_6834 alcohol dehydrogenase from Mycobacterium smegmatis str. MC2 155
36% identity, 99% coverage
- Ribosomal mutations promote the evolution of antibiotic resistance in a multidrug environment
Gomez, eLife 2017 - “...of pUV15tetORm in which the gfp ORF is replaced with a PCR product containing the MSMEG_6834 ORF. Primers were MSMEG_6834_Pac1-F and MSMEG_6834_EcoRV-R, and the resulting product was introduced into pUV15tetORm after digestion of each with PacI and EcoRV. pUV15tetORm and its derivatives express TetR, allowing for...”
- Distinct Responses of Mycobacterium smegmatis to Exposure to Low and High Levels of Hydrogen Peroxide
Li, PloS one 2015 - “...0.00E+00 0.00E+00 -1.1422205 1.36E-159 1.45E-158 msmeg_6687 aldehyde dehydrogenase, thermostable -3.706221 1.64E-29 1.03E-28 -1.5049935 9.36E-12 1.94E-11 msmeg_6834 alcohol dehydrogenase -2.7848309 2.21E-05 5.51E-05 0.08733237 0.840712 0.85579383 fadA acetyl-CoA acetyltransferase -2.7273404 0.00E+00 0.00E+00 0.33348045 5.36E-35 1.86E-34 fadB putative 3-hydroxyacyl-CoA dehydrogenase -2.6949142 0.00E+00 0.00E+00 1.39743214 0 0 msmeg_5199 putative acyl-CoA...”
SGR_6892 putative dehydrogenase from Streptomyces griseus subsp. griseus NBRC 13350
32% identity, 94% coverage
- Structure of an MmyB-like regulator from C. aurantiacus, member of a new transcription factor family linked to antibiotic metabolism in actinomycetes
Xu, PloS one 2012 - “...the transcription of SCO4945. Interestingly, in S. griseus , the orthologs (SGR_6891 for SCO4944 and SGR_6892 for SCO4945) are separated from afsA ( i.e. SGR_6889), which is essential for the synthesis of the -butyrolactone A-factor (2-isocapryloyl-3R-hydroxymethyl-gamma-butyrolactone), by a single gene (SGR_6890). A-factor is a hormone-like signaling...”
- “...and spore formation [34] . Microarray data show that the transcription of both SGR_6891 and SGR_6892 is induced immediately after addition of A-factor to liquid-grown cultures (within 5 min) [35] , suggesting that both genes are part of A-factor regulatory cascade. However, lack of an obvious...”
NCgl0219 alcohol dehydrogenase from Corynebacterium glutamicum ATCC 13032
cg0273 alcohol dehydrogenase from Corynebacterium glutamicum ATCC 13032
34% identity, 96% coverage
- Engineered Corynebacterium glutamicum as the Platform for the Production of Aromatic Aldehydes
Kim, Frontiers in bioengineering and biotechnology 2022 - “...20 genes are as follows: P1/P2 and P3/P4 for NCgl0186 , P7/P8 and P9/P10 for NCgl0219 , P13/P14 and P15/P16 for NCgl0313 , P19/P20 and P21/P22 for NCgl0324 , P25/P26 and P27/P28 for NCgl0503 , P31/P32 and P33/P34 for NCgl0908 , P37/P38 and P39/P40 for NCgl1213...”
- “...from E. coli as a query within the C. glutamicum genome. Ten proteins, that is, NCgl0219, NCgl0313, NCgl0324, NCgl0503, NCgl1003, NCgl1112, NCgl2053, NCgl2277, NCgl2709, and NCgl2952 were classified as candidates that showed a BLASTP expect value less than E 20 . Likewise, three ADHs, that is,...”
- C1 metabolism in Corynebacterium glutamicum: an endogenous pathway for oxidation of methanol to carbon dioxide
Witthoff, Applied and environmental microbiology 2013 - “...Derivative of ATCC 13032 with in-frame deletion of cg0273 Derivative of ald strain with additional in-frame deletion of adhE gene Derivative of ald strain...”
- “...product covering upstream and downstream regions of cg0273 Kanr; pK19mobsacB derivative containing 1,084-bp PCR product covering upstream and downstream regions...”
- The alcohol dehydrogenase gene adhA in Corynebacterium glutamicum is subject to carbon catabolite repression
Arndt, Journal of bacteriology 2007 - “...in ethanol-grown cells of C. glutamicum (3). Five genes (cg0273, cg0387, cg0400, cg2714, and cg3107) were annotated as potential ADH genes in the genome of C....”
- “...gram-negative Pseudomonas aeruginosa. The other four proteins (Cg0273, Cg0387, Cg0400, and Cg2714) showed less similarity (40%) to all these ADHs. Therefore,...”
F1542_13140 zinc-dependent alcohol dehydrogenase family protein from Komagataeibacter sp. FXV3
33% identity, 98% coverage
2eerB / Q96XE0 Structural study of project id st2577 from sulfolobus tokodaii strain7
ST2577 347aa long hypothetical alcohol dehydrogenase from Sulfolobus tokodaii str. 7
33% identity, 96% coverage
PATD_ASPCL / A1CFL1 Alcohol dehydrogenase patD; Patulin synthesis protein D; EC 1.1.1.- from Aspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1 / QM 1276 / 107) (see 3 papers)
45% identity, 63% coverage
- function: Alcohol dehydrogenase; part of the gene cluster that mediates the biosynthesis of patulin, an acetate-derived tetraketide mycotoxin produced by several fungal species that shows antimicrobial properties against several bacteria (By similarity). PatD catalyzes the conversion of neopatulin into E-ascladiol (By similarity). The pathway begins with the synthesis of 6-methylsalicylic acid by the polyketide synthase (PKS) patK via condensation of acetate and malonate units. The 6- methylsalicylic acid decarboxylase patG then catalyzes the decarboxylation of 6-methylsalicylic acid to yield m-cresol (also known as 3-methylphenol). These first reactions occur in the cytosol. The intermediate m-cresol is then transported into the endoplasmic reticulum where the cytochrome P450 monooxygenase patH converts it to m-hydroxybenzyl alcohol, which is further converted to gentisyl alcohol by the cytochrome P450 monooxygenase patI. The oxidoreductases patJ and patO further convert gentisyl alcohol to isoepoxydon in the vacuole. PatN catalyzes then the transformation of isoepoxydon into phyllostine. The cluster protein patF is responsible for the conversion from phyllostine to neopatulin whereas the alcohol dehydrogenase patD converts neopatulin to E-ascladiol. The steps between isoepoxydon and E-ascladiol occur in the cytosol, and E-ascladiol is probably secreted to the extracellular space by one of the cluster-specific transporters patC or patM. Finally, the secreted patulin synthase patE catalyzes the conversion of E-ascladiol to patulin (Probable) (PubMed:19383676).
catalytic activity: neopatulin + NADPH + H(+) = (E)-ascladiol + NADP(+) (RHEA:62224)
cofactor: Zn(2+) (Binds 2 Zn(2+) ions per subunit.)
WP_012643201 zinc-binding dehydrogenase from Thermomicrobium roseum DSM 5159
36% identity, 94% coverage
adh1 / A0QTV3 propan-2-ol dehydrogenase from Mycolicibacterium smegmatis (strain ATCC 700084 / mc(2)155) (see paper)
MSMEG_1977 alcohol dehydrogenase from Mycobacterium smegmatis str. MC2 155
35% identity, 98% coverage
- Monitoring global protein thiol-oxidation and protein S-mycothiolation in Mycobacterium smegmatis under hypochlorite stress
Hillion, Scientific reports 2017 - “...113* B 26,0 16,5 43,8 MSMEG_4400 MSMEG_4400 Alcohol DH, zinc-containing 65 B 27,8 6,4 34,1 MSMEG_1977 MSMEG_1977 Alcohol DH, zinc-containing 39* B 22,8 14,5 30,0 11,9 12,6 27,5 MSMEG_0595 MSMEG_0595 Fe-S oxidoreductase 142* B 13,9 12,4 23,4 7,6 30,2 37,8 MSMEG_0690 MSMEG_0690 Fe-S oxidoreductase 637* B...”
- “...(Adh2) and 6 Adhs showed up-to 39% higher thiol-oxidation levels under NaOCl stress (AdhB1/B2/E1/E2, MSMEG_1138, MSMEG_1977 and MSMEG_4400). It is possible that these Adh enzymes participate in the glycerol oxidation pathway. These Zn-containing Adhs possess an N-terminal conserved catalytic Cys that was identified as NaOCl-sensitive in...”
- Identification of the regulator gene responsible for the acetone-responsive expression of the binuclear iron monooxygenase gene cluster in mycobacteria
Furuya, Journal of bacteriology 2011 - “...energy but not on acetol. MimA (Msmeg_1971) and Msmeg_1977 exhibit significant amino acid similarities (95% and 74%) with the monooxygenase (PrmA) converting...”
- “...enzymologically identified the functions of MimA and Msmeg_1977, these findings suggested that propane might be metabolized via 2-propanol, acetone, and acetol...”
- Gene Expression, Bacteria Viability and Survivability Following Spray Drying of Mycobacterium smegmatis
Lauten, Materials (Basel, Switzerland) 2010 - “...MSMEG_1975 amidohydrolase 2 2.3 10.8 0.00 97% MSMEG_1976 conserved hypothetical protein 2.4 10.2 0.00 100% MSMEG_1977 alcohol dehydrogenase 1.7 10.5 0.00 94% MSMEG_1978 chaperonin GroL groL 2.0 10.5 0.00 89% MSMEG_1979 antibiotic biosynthesis monooxygenase 1.3 11.4 0.00 99% MSMEG_4206 Molybdopterin oxidoreductase 3.1 10.8 0.00 98% MSMEG_4207...”
XF1746 alcohol dehydrogenase from Xylella fastidiosa 9a5c
34% identity, 96% coverage
DDB_G0271780 zinc-containing alcohol dehydrogenase from Dictyostelium discoideum AX4
33% identity, 99% coverage
- Novel RNAseq-Informed Cell-type Markers and Their Regulation Alter Paradigms of Dictyostelium Developmental Control
Forbes, Frontiers in cell and developmental biology 2022 - “...DDB_G0271354* beiH cup grp 4 unknown signal peptide DDB_G0276687 # beiE cup Ddis hssA-related none DDB_G0271780 # beiF cup Ddis unknown ADH_N DDB_G0274317* spoC spo all grps unknown none DDB_G0288489 # spoA spo all grps unknown none Pattern only DDB_G0268250* somB ms + p grp 4...”
- Cell-type specific RNA-Seq reveals novel roles and regulatory programs for terminally differentiated Dictyostelium cells
Kin, BMC genomics 2018 - “...developing structures by -galactosidase histochemistry. The cup genes DDB_G0276687 , an hssA/7E/2C related gene, and DDB_G0271780 , a putative alcohol dehydrogenase were both expressed very late in the spore head in the upper- and lower cup (Fig. 8a , b ), but not in the basal...”
- “...that are not shown were devoid of staining. a - c Cup genes DDB_G0276687 , DDB_G0271780 and tgrR1 . d , e Spore genes DDB_G0288489 and DDB_G0285289 . f - l Stalk genes, DDB_G0280217 , DDB_G0295797, sigK, DDB_G02787091 , DDB_G0279361, expl7 and DDB_G0269904. Bars: 50m, gene...”
pNG7351 zinc-binding dehydrogenase from Haloarcula marismortui ATCC 43049
39% identity, 78% coverage
- Genome information management and integrated data analysis with HaloLex
Pfeiffer, Archives of microbiology 2008 - “...OE3930R, NP0566A pNG7327 1,512 1,572 Shortened HQ1784A, NP0802A, OE1568F pNG7342 1,098 1,128 Shortened pNG7026, OE5170F pNG7351 1,065 1,089 Shortened rrnAC0191, NP1260A, OE4674F, HQ3648A pNG7377 432 324 Extended HQ3372A pNG7380 1,746 1,932 Shortened HQ1768A Using our semiautomatic checking procedure, candidate genes with probable errors in start codon...”
LOC18036047 probable mannitol dehydrogenase from Citrus x clementina
34% identity, 87% coverage
J3U91_00739 zinc-dependent alcohol dehydrogenase family protein from Oenococcus oeni
32% identity, 89% coverage
- Analysis of Transcriptomic Response to SO2 by Oenococcus oeni Growing in Continuous Culture
Onetto, Microbiology spectrum 2021 - “...alpha/citrate CoA-transferase ND 1.09 ND 0.71 J3U91_00415 kch; voltage-gated potassium channel 0.57 1.12 ND 1.21 J3U91_00739 adhP; alcohol dehydrogenase, propanol-preferring ND 1.42 ND ND J3U91_00916 APA; basic amino acid/polyamine antiporter, APA family 0.60 1.52 0.36 0.88 J3U91_00927 pgl; 6-phosphogluconolactonase ND 1.26 ND 0.61 J3U91_00980 arcA; arginine...”
LINJ_23_0410 putative NADP-dependent alcohol dehydrogenase from Leishmania infantum JPCM5
34% identity, 89% coverage
VDAG_03969 alcohol dehydrogenase from Verticillium dahliae VdLs.17
33% identity, 92% coverage
- The bZip Transcription Factor VdMRTF1 is a Negative Regulator of Melanin Biosynthesis and Virulence in Verticillium dahliae
Lai, Microbiology spectrum 2022 - “...enriched in oxidoreductase activity were upregulated, the expression of the rest of DEGs (VDAG_01286, VDAG_03335, VDAG_03969, VDAG_07187, VDAG_07587, VDAG_08214, VDAG_10051, VDAG_10407, and VDAG_10485) were downregulated ( Fig.6D ). These results indicated that VdMRTF1 disrupted the expression of genes involved in oxidoreductase activity and hydrogen peroxide catabolic...”
- “...lowest (Fig.S5B). Among eight DEGs involved in this KEGG pathway, five DEGs (VDAG_03345, VDAG_03922, VDAG_04572, VDAG_03969, and VDAG_04798) were significantly upregulated, while the remaining DEGs (VDAG_10407, VDAG_07197, and VDAG_10051) were significantly downregulated ( Fig.8A ). To verify whether VdMRTF1 is involved in tyrosine metabolism, NTBC (an...”
Rv1862 Probable alcohol dehydrogenase adhA from Mycobacterium tuberculosis H37Rv
34% identity, 93% coverage
- Lineage-Specific Proteomic Signatures in the Mycobacterium tuberculosis Complex Reveal Differential Abundance of Proteins Involved in Virulence, DNA Repair, CRISPR-Cas, Bioenergetics and Lipid Metabolism
Yimer, Frontiers in microbiology 2020 - “...5 7 6-Phosphofructokinase PfkA pfkA Rv3010c 3, 4, 5 7 Probable alcohol dehydrogenase AdhA adhA Rv1862 3, 4, 5 7 Possible L -lactate dehydrogenase (cytochrome) LldD1 LldD1 Rv0694 3, 4, 5 7 Putative citrate synthase II CitA citA Rv0889c 7 3, 4, 5 Isocitrate lyase Icl...”
- From Corynebacterium glutamicum to Mycobacterium tuberculosis--towards transfers of gene regulatory networks and integrated data analyses with MycoRegNet
Krawczyk, Nucleic acids research 2009 - “...( sucC ), Rv0952 ( sucD ), Rv1475c ( acn ) Rv1837c ( glcB ), Rv1862 ( adhA ), Rv2193 ( ctaE ), Rv2241 ( aceE ) Rv2332 ( mez ), Rv2967c ( pca ), Rv3318 ( sdhA ) Cell division and septation Rv1009 ( rpfB...”
- “...( tpi ), Rv1475c ( acn ), Rv1837c ( glcB ), Rv1854c ( ndh ) Rv1862 ( adhA ), Rv1872c ( lldD2 ), Rv2029c ( pfkB ), Rv2193 ( ctaE ) Rv2194 ( qcrC ), Rv2195 ( qcrA ), Rv2196 ( qcrB ), Rv2200c ( ctaC...”
G7JFC2 Cinnamyl alcohol dehydrogenase-like protein from Medicago truncatula
32% identity, 86% coverage
Cbei_3864 alcohol dehydrogenase from Clostridium beijerincki NCIMB 8052
33% identity, 99% coverage
- Molecular characterization of an NADPH-dependent acetoin reductase/2,3-butanediol dehydrogenase from Clostridium beijerinckii NCIMB 8052
Raedts, Applied and environmental microbiology 2014 - “...CBEI_0685, CBEI_1464 (C. beijerinckii ACR [Cb-ACR]), CBEI_2243, CBEI_3864, and CBEI_3890, were amplified by PCR on C. beijerinckii genomic DNA using the...”
- “...CBEI_0223, CBEI_0528, CBEI_0544, CBEI_0685, CBEI_1464, CBEI_2243, CBEI_3864, and CBEI_3890 are all annotated in NCBI (http://www.ncbi.nlm.nih.gov/) as alcohol...”
ST2056 361aa long hypothetical alcohol dehydrogenase from Sulfolobus tokodaii str. 7
33% identity, 91% coverage
C5934_08415 NAD(P)-dependent alcohol dehydrogenase from Cronobacter sakazakii
33% identity, 93% coverage
SAMN05444581_1149 zinc-dependent alcohol dehydrogenase family protein from Methylocapsa palsarum
33% identity, 98% coverage
LOC110941024 probable cinnamyl alcohol dehydrogenase 6 from Helianthus annuus
32% identity, 87% coverage
- Dissecting the Genetic Architecture of Morphological Traits in Sunflower (Helianthus annuus L.)
Delen, Genes 2024 - “...regulator 2, regulating root gravitropic bending and TMK-dependent rapid auxin signaling (LOC110920267); CADH6, biosynthesizing lignin (LOC110941024); and extensin-like, playing a role on physical characteristics of the plant cell wall (LOC110943450). The others detected by farmCPU were as follows: aquaporin PIP2-7, leading the transport of water across...”
- “...the response of the plant immune system (LOC110918080); CADH6, participating in the biosynthesis of lignin (LOC110941024); extensin-like (LOC110943450), having an impact on the physical properties of the plant cell wall. Some other proteins of the genes identified by farmCPU method were as follows: cold-responsive protein kinase...”
CCO1660 probable alcohol dehydrogenase (NADP) Cj1548c from Campylobacter coli RM2228
31% identity, 87% coverage
- Differences in the Transcriptomic Response of Campylobacter coli and Campylobacter lari to Heat Stress
Riedel, Frontiers in microbiology 2020 - “...Down-regulated Energy production and conversion aspA , cydA , hydA2 , ldh , CCO0259, CCO0482, CCO1660 fliI Amino acid transport and metabolism bisZ , dapA , glnA , hisH , potA , proB , serB , CCO1002, CCO1668 ilvE , proC , CCO0338, CCO0845, CCO0846, CCO1354,...”
jhp1429 ZINC-DEPENDENT ALCOHOL DEHYDROGENASE from Helicobacter pylori J99
33% identity, 86% coverage
PSPTO_2697 oxidoreductase, zinc-binding from Pseudomonas syringae pv. tomato str. DC3000
33% identity, 88% coverage
MTD / Q38707 mannitol dehydrogenase (EC 1.1.1.255) from Apium graveolens (see paper)
Q38707 mannitol dehydrogenase (EC 1.1.1.255) from Apium graveolens (see paper)
34% identity, 86% coverage
KGF88_00295 NAD(P)-dependent alcohol dehydrogenase from Idiomarina loihiensis
31% identity, 92% coverage
6isvB / M5A8V4 Structure of acetophenone reductase from geotrichum candidum nbrc 4597 in complex with NAD (see paper)
34% identity, 99% coverage
- Ligands: nicotinamide-adenine-dinucleotide; zinc ion (6isvB)
LT85_RS01775 NAD(P)-dependent alcohol dehydrogenase from Collimonas arenae
30% identity, 98% coverage
D7U461 Enoyl reductase (ER) domain-containing protein from Vitis vinifera
34% identity, 87% coverage
DDB_G0273921 zinc-containing alcohol dehydrogenase from Dictyostelium discoideum AX4
31% identity, 99% coverage
LOC18037214 8-hydroxygeraniol dehydrogenase from Citrus x clementina
33% identity, 86% coverage
- Transcriptome analysis of the pulp of citrus fruitlets suggests that domestication enhanced growth processes and reduced chemical defenses increasing palatability
Perez-Roman, Frontiers in plant science 2022 - “...alkaloid biosynthesis. These upregulated steps are geraniol 8-hydroxylase (5 genes out of 6), 8-hydroxygeraniol dehydrogenase (LOC18037214), the dehydrogenase involved in the biosynthesis of oxogeranial from hydroxygeraniol and 7-deoxyloganetin glucosyltransferase (LOC18042369), an iridoid glucosyltransferase involved in the synthesis of secologanin, one of the major intermediates in the...”
- “...LOC112100740 Probable caffeine synthase 4 Caffeine Up Alkaloids LOC18036840 Codeine O -demethylase Morphine Up Alkaloids LOC18037214 8-Hydroxygeraniol dehydrogenase Vinblastine Up Alkaloids LOC18042369 7-Deoxyloganetin glucosyltransferase Secologanin Up Alkaloids LOC18043348; LOC18046227 tyrosine/DOPA decarboxylase 5 Serotonin Down Alkaloids LOC18041681 Tryptamine 5-hydroxylase (CYP71P1) Serotonin Down Alkaloids LOC18043348; LOC18046227 Tyrosine/DOPA decarboxylase...”
- Combined Transcriptome and Metabolome Analyses Reveal Candidate Genes Involved in Tangor (Citrus reticulata × Citrus sinensis) Fruit Development and Quality Formation
Bi, International journal of molecular sciences 2022 - “...generally down-regulated throughout fruit development and ripeningtwo CAD9 (LOC18036047, LOC18040966), PAL2 (LOC18043571), CCoAOMT (LOC18055676), CAD6 (LOC18037214), HCT (LOC18035960), and EMB3009 (LOC18032863). Additionally, a phenylpropane related gene VS (LOC18037906) was up-regulated during S1 to S2 and down-regulated during S2 to S3. For the flavonoid metabolic pathway, 31...”
Q4QBD8 Putative NADP-dependent alcohol dehydrogenase from Leishmania major
34% identity, 89% coverage
For advice on how to use these tools together, see
Interactive tools for functional annotation of bacterial genomes.
The PaperBLAST database links 793,807 different protein sequences to 1,259,118 scientific articles. Searches against EuropePMC were last performed on March 13 2025.
PaperBLAST builds a database of protein sequences that are linked
to scientific articles. These links come from automated text searches
against the articles in EuropePMC
and from manually-curated information from GeneRIF, UniProtKB/Swiss-Prot,
BRENDA,
CAZy (as made available by dbCAN),
BioLiP,
CharProtDB,
MetaCyc,
EcoCyc,
TCDB,
REBASE,
the Fitness Browser,
and a subset of the European Nucleotide Archive with the /experiment tag.
Given this database and a protein sequence query,
PaperBLAST uses protein-protein BLAST
to find similar sequences with E < 0.001.
To build the database, we query EuropePMC with locus tags, with RefSeq protein
identifiers, and with UniProt
accessions. We obtain the locus tags from RefSeq or from MicrobesOnline. We use
queries of the form "locus_tag AND genus_name" to try to ensure that
the paper is actually discussing that gene. Because EuropePMC indexes
most recent biomedical papers, even if they are not open access, some
of the links may be to papers that you cannot read or that our
computers cannot read. We query each of these identifiers that
appears in the open access part of EuropePMC, as well as every locus
tag that appears in the 500 most-referenced genomes, so that a gene
may appear in the PaperBLAST results even though none of the papers
that mention it are open access. We also incorporate text-mined links
from EuropePMC that link open access articles to UniProt or RefSeq
identifiers. (This yields some additional links because EuropePMC
uses different heuristics for their text mining than we do.)
For every article that mentions a locus tag, a RefSeq protein
identifier, or a UniProt accession, we try to select one or two
snippets of text that refer to the protein. If we cannot get access to
the full text, we try to select a snippet from the abstract, but
unfortunately, unique identifiers such as locus tags are rarely
provided in abstracts.
PaperBLAST also incorporates manually-curated protein functions:
- Proteins from NCBI's RefSeq are included if a
GeneRIF
entry links the gene to an article in
PubMed®.
GeneRIF also provides a short summary of the article's claim about the
protein, which is shown instead of a snippet.
- Proteins from Swiss-Prot (the curated part of UniProt)
are included if the curators
identified experimental evidence for the protein's function (evidence
code ECO:0000269). For these proteins, the fields of the Swiss-Prot entry that
describe the protein's function are shown (with bold headings).
- Proteins from BRENDA,
a curated database of enzymes, are included if they are linked to a paper in PubMed
and their full sequence is known.
- Every protein from the non-redundant subset of
BioLiP,
a database
of ligand-binding sites and catalytic residues in protein structures, is included. Since BioLiP itself
does not include descriptions of the proteins, those are taken from the
Protein Data Bank.
Descriptions from PDB rely on the original submitter of the
structure and cannot be updated by others, so they may be less reliable.
(For SitesBLAST and Sites on a Tree, we use a larger subset of BioLiP so that every
ligand is represented among a group of structures with similar sequences, but for
PaperBLAST, we use the non-redundant set provided by BioLiP.)
- Every protein from EcoCyc, a curated
database of the proteins in Escherichia coli K-12, is included, regardless
of whether they are characterized or not.
- Proteins from the MetaCyc metabolic pathway database
are included if they are linked to a paper in PubMed and their full sequence is known.
- Proteins from the Transport Classification Database (TCDB)
are included if they have known substrate(s), have reference(s),
and are not described as uncharacterized or putative.
(Some of the references are not visible on the PaperBLAST web site.)
- Every protein from CharProtDB,
a database of experimentally characterized protein annotations, is included.
- Proteins from the CAZy database of carbohydrate-active enzymes
are included if they are associated with an Enzyme Classification number.
Even though CAZy does not provide links from individual protein sequences to papers,
these should all be experimentally-characterized proteins.
- Proteins from the REBASE database
of restriction enzymes are included if they have known specificity.
- Every protein with an evidence-based reannotation (based on mutant phenotypes)
in the Fitness Browser is included.
- Sequence-specific transcription factors (including sigma factors and DNA-binding response regulators)
with experimentally-determined DNA binding sites from the
PRODORIC database of gene regulation in prokaryotes.
- Putative transcription factors from RegPrecise
that have manually-curated predictions for their binding sites. These predictions are based on
conserved putative regulatory sites across genomes that contain similar transcription factors,
so PaperBLAST clusters the TFs at 70% identity and retains just one member of each cluster.
- Coding sequence (CDS) features from the
European Nucleotide Archive (ENA)
are included if the /experiment tag is set (implying that there is experimental evidence for the annotation),
the nucleotide entry links to paper(s) in PubMed,
and the nucleotide entry is from the STD data class
(implying that these are targeted annotated sequences, not from shotgun sequencing).
Also, to filter out genes whose transcription or translation was detected, but whose function
was not studied, nucleotide entries or papers with more than 25 such proteins are excluded.
Descriptions from ENA rely on the original submitter of the
sequence and cannot be updated by others, so they may be less reliable.
Except for GeneRIF and ENA,
the curated entries include a short curated
description of the protein's function.
For entries from BioLiP, the protein's function may not be known beyond binding to the ligand.
Many of these entries also link to articles in PubMed.
For more information see the
PaperBLAST paper (mSystems 2017)
or the code.
You can download PaperBLAST's database here.
Changes to PaperBLAST since the paper was written:
- November 2023: incorporated PRODORIC and RegPrecise. Many PRODORIC entries were not linked to a protein sequence (no UniProt identifier), so we added this information.
- February 2023: BioLiP changed their download format. PaperBLAST now includes their non-redundant subset. SitesBLAST and Sites on a Tree use a larger non-redundant subset that ensures that every ligand is represented within each cluster. This should ensure that every binding site is represented.
- June 2022: incorporated some coding sequences from ENA with the /experiment tag.
- March 2022: incorporated BioLiP.
- April 2020: incorporated TCDB.
- April 2019: EuropePMC now returns table entries in their search results. This has expanded PaperBLAST's database, but most of the new entries are of low relevance, and the resulting snippets are often just lists of locus tags with annotations.
- February 2018: the alignment page reports the conservation of the hit's functional sites (if available from from Swiss-Prot or UniProt)
- January 2018: incorporated BRENDA.
- December 2017: incorporated MetaCyc, CharProtDB, CAZy, REBASE, and the reannotations from the Fitness Browser.
- September 2017: EuropePMC no longer returns some table entries in their search results. This has shrunk PaperBLAST's database, but has also reduced the number of low-relevance hits.
Many of these changes are described in Interactive tools for functional annotation of bacterial genomes.
PaperBLAST cannot provide snippets for many of the papers that are
published in non-open-access journals. This limitation applies even if
the paper is marked as "free" on the publisher's web site and is
available in PubmedCentral or EuropePMC. If a journal that you publish
in is marked as "secret," please consider publishing elsewhere.
Many important articles are missing from PaperBLAST, either because
the article's full text is not in EuropePMC (as for many older
articles), or because the paper does not mention a protein identifier such as a locus tag, or because of PaperBLAST's heuristics. If you notice an
article that characterizes a protein's function but is missing from
PaperBLAST, please notify the curators at UniProt
or add an entry to GeneRIF.
Entries in either of these databases will eventually be incorporated
into PaperBLAST. Note that to add an entry to UniProt, you will need
to find the UniProt identifier for the protein. If the protein is not
already in UniProt, you can ask them to create an entry. To add an
entry to GeneRIF, you will need an NCBI Gene identifier, but
unfortunately many prokaryotic proteins in RefSeq do not have
corresponding Gene identifers.
References
PaperBLAST: Text-mining papers for information about homologs.
M. N. Price and A. P. Arkin (2017). mSystems, 10.1128/mSystems.00039-17.
Europe PMC in 2017.
M. Levchenko et al (2017). Nucleic Acids Research, 10.1093/nar/gkx1005.
Gene indexing: characterization and analysis of NLM's GeneRIFs.
J. A. Mitchell et al (2003). AMIA Annu Symp Proc 2003:460-464.
UniProt: the universal protein knowledgebase.
The UniProt Consortium (2016). Nucleic Acids Research, 10.1093/nar/gkw1099.
BRENDA in 2017: new perspectives and new tools in BRENDA.
S. Placzek et al (2017). Nucleic Acids Research, 10.1093/nar/gkw952.
The EcoCyc database: reflecting new knowledge about Escherichia coli K-12.
I. M. Keeseler et al (2016). Nucleic Acids Research, 10.1093/nar/gkw1003.
The MetaCyc database of metabolic pathways and enzymes.
R. Caspi et al (2018). Nucleic Acids Research, 10.1093/nar/gkx935.
CharProtDB: a database of experimentally characterized protein annotations.
R. Madupu et al (2012). Nucleic Acids Research, 10.1093/nar/gkr1133.
The carbohydrate-active enzymes database (CAZy) in 2013.
V. Lombard et al (2014). Nucleic Acids Research, 10.1093/nar/gkt1178.
The Transporter Classification Database (TCDB): recent advances
M. H. Saier, Jr. et al (2016). Nucleic Acids Research, 10.1093/nar/gkv1103.
REBASE - a database for DNA restriction and modification: enzymes, genes and genomes.
R. J. Roberts et al (2015). Nucleic Acids Research, 10.1093/nar/gku1046.
Deep annotation of protein function across diverse bacteria from mutant phenotypes.
M. N. Price et al (2016). bioRxiv, 10.1101/072470.
by Morgan Price,
Arkin group
Lawrence Berkeley National Laboratory