PaperBLAST
PaperBLAST Hits for 13241 (77 a.a., FVCELCGETF...)
Show query sequence
>13241
FVCELCGETFTRRYNLRGHQRAHKGEKPYKCSYEGCDKAFARAHDCKRHELLHLGVRKYH
CSPCNRDFVRLDALHRH
Running BLASTp...
Found 566 similar proteins in the literature:
CRZ1_CRYNH / J9VE33 Transcriptional regulator CRZ1 from Cryptococcus neoformans var. grubii serotype A (strain H99 / ATCC 208821 / CBS 10515 / FGSC 9487) (Filobasidiella neoformans var. grubii) (see 9 papers)
59% identity, 7% coverage
- function: DNA-binding transcriptional activator that interacts with calcineurin-dependent response element (CDRE) promoters (PubMed:28376087). Activates expression of genes required to maintain cell wall integrity during stress (PubMed:23251520, PubMed:28376087). Activates expression of genes required for transepithelial migration through the host blood-brain barrier (PubMed:29113016). Required for adaptation to host temperature during infection (PubMed:28376087).
disruption phenotype: Decreases virulence in a mouse intranasal inhalation model and intravenous model for infection (PubMed:21487010, PubMed:27611567, PubMed:28376087, PubMed:29233914). Decreases virulence in a moth model (PubMed:28376087). Decreases urease activity (PubMed:29113016). Decreases levels of: laccase and melanin (PubMed:21487010). Hypercapsular with mucoid colony morphology (PubMed:21487010). Sensitive to: calcium; lithium; sodium nitrite; high temperature; sodium dodecyl sulfate (cell wall stress inducer); Calcofluor White (cell wall stress inducer); Congo Red (cell wall stress inducer); caspofungin (cell wall stress inducer) (PubMed:21487010, PubMed:27611567, PubMed:28376087, PubMed:29233914, PubMed:31266771). Abolishes filamentation during growth on glucosamine carbon source (PubMed:28898238). Decreases RNA level of genes involved in membrane transport, carbohydrate metabolism, signaling, DNA replication, and sterol biosynthesis during heat stress (PubMed:28376087). Decreases CHS5 and CHS6 RNA level during heat stress (PubMed:27611567, PubMed:28376087). Decreases RNA level of ZNF2 during growth on glucosamine carbon source (PubMed:28898238). Increases MFalpha1 expression during mating (PubMed:27611567). Normal hyphal morphology during mating (PubMed:23251520, PubMed:28376087). Simultaneous disruption of HAD1, PUF4 or LHP1 results in phenotypic enhancement (PubMed:27611567, PubMed:29233914).
XP_566613 hypothetical protein from Cryptococcus neoformans var. neoformans JEC21
CNA01450 conserved hypothetical protein from Cryptococcus neoformans var. neoformans JEC21
59% identity, 7% coverage
- The Crz1/Sp1 transcription factor of Cryptococcus neoformans is activated by calcineurin and regulates cell wall integrity
Lev, PloS one 2012 - “...Swi5 and Ace2 represent transcription factors related to ScCrz1 Cn_H99, Cryptococcus neoformans serotype A; Cn_JEC21, XP_566613, C. neoformans serotype D; An, BAE94327, Aspergillus nidulans ; Ao, BAE57003, Aspergillus oryzae ; Af, EAL88401, Aspergillus fumigatus ; Mo, XP_359644, Magnaporthe oryzae ; Nc, EAA32849, Neurospora crassa ; EAQ88414,...”
- “...The following fungal proteins were used for the alignment: Cn_H99, Cryptococcus neoformans serotype A; Cn_JEC21, XP_566613, C. neoformans serotype D; An, BAE94327, Aspergillus nidulans ; Ao, BAE57003, Aspergillus oryzae ; Af, EAL88401, Aspergillus fumigatus ; Mo, XP_359644, Magnaporthe oryzae ; Nc, EAA32849, Neurospora crassa ; EAQ88414,...”
- Zinc Finger Proteins in the Human Fungal Pathogen Cryptococcus neoformans
Li, International journal of molecular sciences 2020 - “...2 Important component of the Qsp1-signaling cascade required for sexual reproduction [ 82 ] Crz1 CNA01450 Znf_C 2 H 2 Regulates the sporulation process [ 68 ] Crz1 CNAG_00156 Znf_C 2 H 2 Cell integrity; Proliferation and survival under reduced aeration; Biofilm formation and susceptibility to...”
- Dissecting the Roles of the Calcineurin Pathway in Unisexual Reproduction, Stress Responses, and Virulence in Cryptococcus deneoformans
Fu, Genetics 2018 - “...(CNA1), CND00260 (CNB1), CNA07790 (CBP1), CNG01630 (CTS1), CNA01450 (CRZ1), CNE04890 (PBP1), CNK00210 (TIF3), and CNC04280 (PUF4) (Stajich et al. 2012; Park...”
- Conserved elements of the RAM signaling pathway establish cell polarity in the basidiomycete Cryptococcus neoformans in a divergent fashion from other fungi
Walton, Molecular biology of the cell 2006 - “...matches to S. cerevisiae Ace2. The closest match (e-11), CNA01450, is predicted to contain two C2H2 Zn finger domains at its C-terminal end (like Ace2)....”
- “...more similar to Crz1 or Swi5 than to Ace2. Furthermore, CNA01450 is also the closest match when S. cerevisiae Crz1 is used to search the C. neoformans genome....”
CRZ1_CANAL / Q5A4H5 Transcriptional regulator CRZ1; Calcineurin-responsive zinc finger protein 1 from Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast) (see 7 papers)
CRZ1 potential zinc finger protein from Candida albicans (see 7 papers)
XP_716600 DNA-binding transcription factor from Candida albicans SC5314
48% identity, 11% coverage
NCU07952, XP_962085 C2H2 type zinc finger domain-containing protein from Neurospora crassa OR74A
51% identity, 11% coverage
- The GUL-1 Protein Binds Multiple RNAs Involved in Cell Wall Remodeling and Affects the MAK-1 Pathway in Neurospora crassa
Herold, Frontiers in fungal biology 2021 - “...members of the core assembly were another RBPVTS-1 (NCU00311)and a C2H2-type zinc-finger domain transcription factor (NCU07952). When nitrogen-limiting conditions were imposed, 205 proteins co-immunoprecipitated with GUL-1. 163 proteins (cluster IV) were unique to these conditions and included several SG proteins (e.g., 11 different 40S subunit proteins)....”
- “...2012 ) and in N. crassa cell fusion (Fu et al., 2014 ) and VSD-9 (NCU07952) whose absence confers defects in sexual development (Carrillo et al., 2017 ). Some of the proteins detected represent the networks which we have previously identified to be altered at the...”
- Functional Characterization of Calcineurin-Responsive Transcription Factors Fg01341 and Fg01350 in Fusarium graminearum
Zhang, Frontiers in microbiology 2020 - “...graminearum (FGSG_01341, FGSG_01350, FGSG_10470, FGSG_06311, and FGSG_13711), C. neoformans (CNAG_00156), M. oryzae (MGG_05133), N. crassa (NCU07952), B. cinerea (BCIN_01g08230), A. fumigatus (AFUA_1G06900), and S. cerevisiae (CRZ1). Ca 2 + signals were transmitted by regulating the key transcription factor Crz1 through dephosphorylation and its nuclear translocation. To...”
- Function of crzA in Fungal Development and Aflatoxin Production in Aspergillus flavus
Lim, Toxins 2019 - “...516 65 (Aspgl1_0031266), Neosartorya fischeri NRRL 181 (NFIA_017790), Penicillium digitatum Pd1 (XP_014531047.1), Neurospora crassa OR74A (XP_962085), Magnaporthe oryzae 70-15 (MGG_05133), and Fusarium graminearum PH-1 (FGSG_01341). A phylogenetic tree of CrzA homologs (or orthologs) was generated by the Clustal Omega package ( https://www.ebi.ac.uk/Tools/msa/clustalo/ ). The tree result...”
- Cold Shock as a Screen for Genes Involved in Cold Acclimatization in Neurospora crassa
Watters, G3 (Bethesda, Md.) 2018 - “...zinc-regulated transporter 1 tzn-1 Morph/Hyph Transporter Activity Cellular Process NCU07900 11446 hypothetical protein Transc Factors NCU07952 11494 zinc finger transcription factor-37 znf-37 Transc Factors NCU08049 11047 hypothetical protein Transc Factors NCU08050 15817 hypothetical protein Morph/Hyph NCU08055 11269 zip-like-1 zip-1 Transc Factors Binding Response to Stimulus/Cellular Process/Metabolic...”
- Functional Profiling of Transcription Factor Genes in Neurospora crassa
Carrillo, G3 (Bethesda, Md.) 2017 - “...had a reduced number of perithecial beaks (C2H2 genes cre-1 / NCU08807 and vsd-9 / NCU07952 , BHLH dsd-3 / NCU05970 , and APSES vsd-5 / NCU07587 ; Table S1 ). The beak defect of vsd-5 is presented in Figure 4B . Correlation between phenotypes and...”
- “...when ascospores are produced (Figure S2B in File S1 ). The C2H2 genes vsd-9 / NCU07952 (reduced ascospores) and NCU03699 (no sexual phenotype) are coordinately expressed, with a dip at 48hr (time of meiosis) and 144hr (ascospore maturation) (Figure S2B in File S1 ). The C6...”
- Regulation of the reserve carbohydrate metabolism by alkaline pH and calcium in Neurospora crassa reveals a possible cross-regulation of both signaling pathways
Virgilio, BMC genomics 2017 - “...the transcription factor activated by calcineurin under calcium stress [ 34 ], we identified the NCU07952 gene product (named CRZ-1) as the putative N. crassa homolog protein. Sequence alignment of the N. crassa CRZ-1, Aspergillus fumigatus and A. nidulans CrzA and Trichoderma reesei CRZ-1 was performed...”
- “...4: Figure S3. Multiple sequence alignment of the N. crassa protein codified by the ORF NCU07952 and the CrzA proteins from A. fumigatus (XP_750439.1) and A. nidulans (BAE94327.1), and the CRZ-1 protein from Trichoderma reesei (ETS01683.1). The C 2 H 2 zinc finger DNA binding domain...”
- The Hsp90 Co-chaperones Sti1, Aha1, and P23 Regulate Adaptive Responses to Antifungal Azoles
Gu, Frontiers in microbiology 2016 - “...FGSC#11922 a + fkr-5 (PPIase FKBP-type) FKBP52 family NCU02455 FGSC#12999 a crz1 Calcineurin-responsive zinc finger NCU07952 FGSC#11494 a, het p23sti1 double mutation NCU01792 , NCU00714 This study p23aha1 double mutation NCU01792 , NCU04087 This study * het, heterokaryon ; ** NA, Not Available (in FGSC) ;...”
- Synergistic and Dose-Controlled Regulation of Cellulase Gene Expression in Penicillium oxalicum
Li, PLoS genetics 2015 - “...Hypothetical protein NCU03070 5.00E-19 121074 5.00E-15 ++ PDE_02584 zf-H2C2_2 C2H2 type zinc finger domain-containing protein NCU07952 e-116 36391 e-123 + PDE_09881 Zn2Cys6 Short aerial hyphae-3 NCU07535 6.00E-44 123445 4.00E-49 + PDE_01512 Bromodomain Porin-binding domain protein-1 NCU02354 e-179 62493 0 + PDE_07134 zf-C2H2_4 Conidial separation-1 NCU02713 6.00E-23...”
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PRZ1_SCHPO / Q09838 Transcriptional regulator prz1; Pbp1-responsive zinc finger protein 1 from Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) (see 2 papers)
prz1 / RF|NP_593073.1 calcineurin responsive transcription factor Prz1 from Schizosaccharomyces pombe (see 3 papers)
SPAC4G8.13c transcription factor Prz1 (PMID 12637524) from Schizosaccharomyces pombe
NP_593073 calcineurin-responsive transcription factor Prz1 from Schizosaccharomyces pombe
47% identity, 11% coverage
- function: Involved in the regulation of calcium ion homeostasis. Binds to the calcineurin-dependent response element. Transcriptionally regulates pmc1.
- CharProtDB Source (per GeneDB): GeneDB_Spombe
- A comparative analysis of telomere length maintenance circuits in fission and budding yeast
Peretz, Frontiers in genetics 2022 - “...family YAL019W FUN30 ATPase Fft3 SPCC18B5.11c cds1 DNA replication YPL153C RAD53 (*) checkpoint kinase Cds1 SPAC4G8.13c prz1 DNA-binding transcription YNL027W CRZ1 factor, calcineurin responsive Prz1 SPAC607.09c btn1 battenin CLN3 YJL059W YHC3 family protein SPAC1687.15 gsk3 serine/threonine YMR139W RIM11 protein kinase Gsk3 (*) indicates a known budding...”
- Conserved rules govern genetic interaction degree across species
Koch, Genome biology 2012 - “...The query strains were deletion mutants for each of the following genes: SPCC1682.08c, SPBC21D10.12, SPBC13E7.09, SPAC4G8.13c, SPAC3A11.13, SPAC27D7.13c, SPAC22F3.09c, SPAC16A10.07c. The resulting double mutant colonies were processed as described in [ 6 ]. Negative interactions were derived from the scores by applying an interaction cutoff of...”
- “...eight queries that were screened for genetic interactions with non-essential genes are SPCC1682.08c, SPBC21D10.12, SPBC13E7.09, SPAC4G8.13c, SPAC3A11.13, SPAC27D7.13c, SPAC22F3.09c, and SPAC16A10.07c. Click here for file Additional file 10 Cross-species degree comparisons of protein complexes . Orthologous sets of genes, the predicted and observed average degrees of...”
- cAMP-dependent protein kinase involves calcium tolerance through the regulation of Prz1 in Schizosaccharomyces pombe.
Matsuo, Bioscience, biotechnology, and biochemistry 2017 (PubMed)- GeneRIF: Pka1 is essential for tolerance to exogenous CaCl2, probably because the expression level of Prz1 needs to be properly regulated by Pka1
- Negative feedback regulation of calcineurin-dependent Prz1 transcription factor by the CaMKK-CaMK1 axis in fission yeast.
Cisneros-Barroso, Nucleic acids research 2014 - GeneRIF: This study reveals that Cmk1 kinase activated by the newly identified Ckk2 counteracts calcineurin function by negatively regulating Prz1 activity which in turn is involved in activating cmk1 gene transcription.
- Genetic screening for regulators of Prz1, a transcriptional factor acting downstream of calcineurin in fission yeast.
Koike, The Journal of biological chemistry 2012 - GeneRIF: Rad24 and Rad25 negatively regulate Prz1 and that Pka1, Msn5, Pac1, Tfs1, and Ape2 also regulate Prz1.
- The Crz1/Sp1 transcription factor of Cryptococcus neoformans is activated by calcineurin and regulates cell wall integrity
Lev, PloS one 2012 - “...CAG80473, Yarrowia lipolytica ; Ca, EAK97605, Candida albicans ; Cgl, CAG62620, Candida glabrata ; Sp, Q09838, Schizosaccharomyces pombe ; Cd, CAX43071, Candida dubliniensis ; Sc_Ace2, CAA97702, Saccharomyces cerevisiae ; Sc_Swi5, CAA90369, Saccharomyces cerevisiae . Indicate what the red numbers mean. Yeast two hybrid analysis has been...”
- “...CAG80473, Yarrowia lipolytica ; Ca, EAK97605, Candida albicans ; Cgl, CAG62620, Candida glabrata ; Sp, Q09838, Schizosaccharomyces pombe ; Cd, CAX43071, Candida dubliniensis ; Sc_Ace2, CAA97702, Saccharomyces cerevisiae ; Sc_Swi5, CAA90369, Saccharomyces cerevisiae . Zinc finger domain sequences were manually extracted from the alignment and used...”
- Calcineurin-responsive zinc finger transcription factor CRZ1 of Botrytis cinerea is required for growth, development, and full virulence on bean plants
Schumacher, Eukaryotic cell 2008 - “...(49), S. cerevisiae (P53968) (42), S. pombe (Q09838) (29), T. delbrueckii (AAZ04388) (28), and B. cinerea (BC1G_00093.1) (Botrytis cinerea Database...”
CRZ1_YEAST / P53968 Transcriptional regulator CRZ1 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see 4 papers)
NP_014371 DNA-binding transcription factor CRZ1 from Saccharomyces cerevisiae S288C
NP_014371, YNL027W Crz1p from Saccharomyces cerevisiae
49% identity, 11% coverage
- function: Involved in the regulation of calcium ion homeostasis. Binds to the calcineurin-dependent response element. Transcriptionally regulates PMC1, PMR1, PMR2A and FKS2.
- Mechanism of enhanced salt tolerance in Saccharomyces cerevisiae by CRZ1 overexpression.
Zuo, Scientific reports 2024 - GeneRIF: Mechanism of enhanced salt tolerance in Saccharomyces cerevisiae by CRZ1 overexpression.
- Optogenetic Control Reveals Differential Promoter Interpretation of Transcription Factor Nuclear Translocation Dynamics.
Chen, Cell systems 2020 - GeneRIF: Optogenetic Control Reveals Differential Promoter Interpretation of Transcription Factor Nuclear Translocation Dynamics.
- The CRaZy Calcium Cycle.
Espeso, Advances in experimental medicine and biology 2016 (PubMed)- GeneRIF: CRZ1 mediates transcriptional regulation of a large number of genes of diverse pathways including a negative feedback regulation of the calcium homeostasis system. (Review)
- Regulation of the Na+/K+-ATPase Ena1 Expression by Calcineurin/Crz1 under High pH Stress: A Quantitative Study.
Petrezsélyová, PloS one 2016 - GeneRIF: Experimental data and mathematical models substantiate the existence of two stress-responsive Crz1-binding sites in the ENA1 promoter and estimate that the contribution of Crz1 to the early response of the ENA1 promoter is about 60%.
- Genome-wide recruitment profiling of transcription factor Crz1 in response to high pH stress.
Roque, BMC genomics 2016 - GeneRIF: Study defines at the genomic-wide level the kinetics of binding of Crz1 to gene promoters in response to alkaline stress, confirms diverse previously known Crz1 targets and identifies many putative novel ones.
- Loss of Ypk1, the yeast homolog to the human serum- and glucocorticoid-induced protein kinase, accelerates phospholipase B1-mediated phosphatidylcholine deacylation.
Surlow, The Journal of biological chemistry 2014 - GeneRIF: Ypk1 and Plb1 interact to alter sphingolipid metabolism up-regulates PLB1 expression via Crz1
- Arsenic stress elicits cytosolic Ca(2+) bursts and Crz1 activation in Saccharomyces cerevisiae.
Ferreira, Microbiology (Reading, England) 2012 (PubMed)- GeneRIF: These data establish that activation of Ca(2+) signalling pathways and the downstream activation of the Crz1 transcription factor contribute to arsenic tolerance in the eukaryotic model organism Saccharomyces cerevisiae.
- Calcineurin/Crz1 destabilizes Msn2 and Msn4 in the nucleus in response to Ca(2+) in Saccharomyces cerevisiae.
Takatsume, The Biochemical journal 2010 (PubMed)- GeneRIF: Crz1 destabilizes Msn2/Msn4 in the nuclei of cells in response to Ca2+ signalling.
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- PuCRZ1, an C2H2 transcription factor from Polyporus umbellatus, positively regulates mycelium response to osmotic stress
Han, Frontiers in microbiology 2023 - “...ID Expression Uniprot ID Annotation Function PU262.4 Down P47043 ZAP1 Zinc ion homeostasis PU50.217 Down P53968 CRZ1 Calcium ion homeostasis. Binds to the calcineurin-dependent response element. Transcriptionally regulates PMC1, PMR1, PMR2A, and FKS2. PU198.24 Up Q9UTA1 C 2 5B8.19c DNA-binding transcription repressor activity PU64.63 Up Q01981...”
- Calcineurin-responsive zinc finger transcription factor CRZ1 of Botrytis cinerea is required for growth, development, and full virulence on bean plants
Schumacher, Eukaryotic cell 2008 - “...B. cinerea: C. albicans (XP_716600) (49), S. cerevisiae (P53968) (42), S. pombe (Q09838) (29), T. delbrueckii (AAZ04388) (28), and B. cinerea (BC1G_00093.1)...”
- A comparative analysis of telomere length maintenance circuits in fission and budding yeast
Peretz, Frontiers in genetics 2022 - “...Fft3 SPCC18B5.11c cds1 DNA replication YPL153C RAD53 (*) checkpoint kinase Cds1 SPAC4G8.13c prz1 DNA-binding transcription YNL027W CRZ1 factor, calcineurin responsive Prz1 SPAC607.09c btn1 battenin CLN3 YJL059W YHC3 family protein SPAC1687.15 gsk3 serine/threonine YMR139W RIM11 protein kinase Gsk3 (*) indicates a known budding yeast TLM gene. Product...”
- A widespread inversion polymorphism conserved among Saccharomyces species is caused by recurrent homogenization of a sporulation gene family
Salzberg, PLoS genetics 2022 - “...of RNA polymerase II holoenzyme YNL026W SAM50 Component of mitochondrial Sorting and Assembly Machinery complex YNL027W CRZ1 Transcription factor, activates stress response genes YNL029C KTR5 Putative mannosyltransferase involved in protein glycosylation YNL030W HHF2 Histone H4 YNL031C HHT2 Histone H3 YNL032W SIW14 Inositol phosphatase involved in inositol...”
- Investigation the global effect of rare earth gadolinium on the budding Saccharomyces cerevisiae by genome-scale screening
Cao, Frontiers in microbiology 2022 - “...PHO2 Homeobox transcription factor, activates transcription cooperatively with Pho4p in response to phosphate starvation nucleus YNL027W CRZ1 Transcription factor of the Ca 2+ signaling pathway nucleus Protein synthesis, folding, modification, and destination (6) YLR441C RPS1A Ribosomal protein 10 of the small subunit cytoplasm YEL042W GDA1 Guanosine...”
- Proteomic analysis revealed the roles of YRR1 deletion in enhancing the vanillin resistance of Saccharomyces cerevisiae
Cao, Microbial cell factories 2021 - “...factor YAP1 1.60 YPR008W Haa1 Transcriptional activator involved in adaptation to weak acid stress 1.57 YNL027W Crz1 Transcription factor, activates transcription of stress response genes 1.75 YMR074C Sod2 Superoxide dismutase 1.32 YJR104C Sod1 Superoxide dismutase 1.39 YDL110C Tma17 ATPase dedicated chaperone that adapts proteasome assembly to...”
- Reconstructing the regulatory circuit of cell fate determination in yeast mating response
Shao, PLoS computational biology 2017 - “...were not significantly regulated as observed in a former study [ 28 ], including YGL252C, YNL027W, YDL080C, YKL222C, YBR289W and YML099C. The resulting profile is also in agreement with the median trajectory of all the protein synthesis rates. The protein synthesis shows a ~40% reduction after...”
- Elucidation of the calcineurin-Crz1 stress response transcriptional network in the human fungal pathogen Cryptococcus neoformans
Chow, PLoS genetics 2017 - “...Reciprocal protein BLAST results of C . neoformans Crz1 (CNAG_00156) against S . cerevisiae Crz1; YNL027W, C . albicans Crz1; ORF19.7359, C . glabrata Crz1; CAGLOM06831g, A . nidulans crzA; AN5726, A . fumigatus crzA; Afulg06900, S . pombe Prz1; SPAC4G8.13c, and M . oryzae Crz1;...”
- Untargeted metabolomics unravels functionalities of phosphorylation sites in Saccharomyces cerevisiae
Raguz, BMC systems biology 2016 - “...of mutation within protein Mutation type Mutant nomenclature Protein type Pathways contribution Evidence type Crz1 YNL027W 409, 410, 423, 427, 429 p-deletion Crz1 OUT TF HOG pathway ch [ 38 , 61 ] Cys3 YAL012W 39, 40 p-deletion Cys3 OUT Enzyme metabolic enzyme dif [ 11...”
- Identification of Genes in Candida glabrata Conferring Altered Responses to Caspofungin, a Cell Wall Synthesis Inhibitor
Rosenwald, G3 (Bethesda, Md.) 2016 - “...sensor Vacuole CAGL0F06347g YMR054W STV1 Subunit a of the vacuolar-ATPase V0 domain Transcriptional/translational regulation CAGL0M06831g YNL027w CRZ1 TF, activates transcription of stress response genes CAGL0J10120g YNL068c FKH2 Forkhead family transcription factor CAGL0M13431g YHR187w IKI1 Subunit of hexameric RecA-like ATPase Elp456 elongator subcomplex CAGL0C04477g YDL005c MED2 Subunit...”
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CRZA_ASPFU / Q4WJ81 C2H2 finger domain transcription factor crzA from Aspergillus fumigatus (strain ATCC MYA-4609 / CBS 101355 / FGSC A1100 / Af293) (Neosartorya fumigata) (see 6 papers)
AFUA_1G06900, Afu1g06900, XP_750439 C2H2 transcription factor Crz1, putative from Aspergillus fumigatus Af293
50% identity, 10% coverage
- function: Transcription factor involved in the regulation of calcium ion homeostasis (PubMed:18298443). Regulates genes encoding calcium transporters, transcription factors and genes that could be directly or indirectly involved in calcium metabolism (PubMed:20078882). Supports especially pmcA, pmcB and pmcC expression encoding for calcium- translocating P-type ATPases (PubMed:18298443, PubMed:22649543). Binds target promoters at motif A[GT][CG]CA[AC][AG] (PubMed:25196896). Plays an essential role germination, radial growth, and asexual development (PubMed:18298443, PubMed:18456861). Also plays a major role in proper chitin and glucan incorporation into the cell wall (PubMed:19015336). Involved in the high-osmolarity glycerol response (HOG) signaling pathway (PubMed:25196896). Required for pathogenicity in an experimental murine model of invasive pulmonary aspergillosis (PubMed:18298443, PubMed:18456861, PubMed:22649543, PubMed:25196896).
disruption phenotype: Leads to reduced levels of beta-1,3-glucan in the cell wall and impairs pathogenicity in an experimental murine model of invasive pulmonary aspergillosis (PubMed:18298443, PubMed:18456861, PubMed:19015336). Increases sensitivity to heat shock (PubMed:18298443). - Functional Genomic and Biochemical Analysis Reveals Pleiotropic Effect of Congo Red on Aspergillus fumigatus
Liu, mBio 2021 - “...wall antifungal drugs Strain Gene ID Description Sensitivity a CR CFW Caspofungin Nikkomycin Z 1B4 AFUA_1G06900 C 2 H 2 transcription factor (CrzA) + + + + + + +/ + + + 1D4 AFUA_1G15230 C6 transcription factor (CrrA) + + + + + + +...”
- Analysis of putative quadruplex-forming sequences in fungal genomes: novel antifungal targets?
Warner, Microbial genomics 2021 - “...Afu1g05800 mkk2 Putative mitogen-activated protein kinase kinase (MAPKK) GG TC GG T GGG T GG Afu1g06900 crzA C2H2-type zinc finger transcription factor involved in calcium ion homeostasis GG AAT GGG A GG A GGG Afu1g10080 zafA Putative C2H2 zinc-responsive transcriptional activator GGG CA GGG CAGAGCA GGG...”
- Aspergillus fumigatus biofilms: Toward understanding how growth as a multicellular network increases antifungal resistance and disease progression
Morelli, PLoS pathogens 2021 - “...Afu5g11230 Regulates stages of conidial germination in response to carbon sources [ 40 ] crzA Afu1g06900 Mediator of calcineurin signaling null mutants have reduced germination [ 41 ] calA Afu3g09690 Binds host integrin to facilitate invasion of host tissue [ 55 , 56 ] uge3 Afu3g07910...”
- Functional Characterization of Calcineurin-Responsive Transcription Factors Fg01341 and Fg01350 in Fusarium graminearum
Zhang, Frontiers in microbiology 2020 - “...FGSG_13711), C. neoformans (CNAG_00156), M. oryzae (MGG_05133), N. crassa (NCU07952), B. cinerea (BCIN_01g08230), A. fumigatus (AFUA_1G06900), and S. cerevisiae (CRZ1). Ca 2 + signals were transmitted by regulating the key transcription factor Crz1 through dephosphorylation and its nuclear translocation. To demonstrate whether Fg06103 ( FGSG_06103 ,...”
- Phosphoproteomics of Aspergillus fumigatus Exposed to the Antifungal Drug Caspofungin
Mattos, mSphere 2020 - “...fap1 b NF-X1 finger transcription factor, putative AFUA_3G11960 fkh2 b Forkhead transcription factor Fkh1/2, putative AFUA_1G06900 crzA C2H2 finger domain transcription factor CrzA AFUA_2G17220 amdX C2H2 transcription factor (AmdX), putative AFUA_2G14800 hpa3 HLH transcription factor (HpaIII), putative AFUA_5G03430 rum1 PHD transcription factor (Rum1), putative AFUA_6G09930 yap1...”
- Molecular Mechanisms of Conidial Germination in Aspergillus spp
Baltussen, Microbiology and molecular biology reviews : MMBR 2020 (secret) - Function of crzA in Fungal Development and Aflatoxin Production in Aspergillus flavus
Lim, Toxins 2019 - “...23 fungal species including A. flavus AFL3357 (AFL2T_09134), A. oryzae RIB40 (AO090001000491), A. fumigatus Af293 (Afu1g06900), A. nidulans FGSC4 (AN5726), A. niger CBS 513.88 (An18g05920), A. clavatus NRRL 1 (ACLA_027670), A. sydowii (Aspsy1_0149570), A. tubingensis CBS 134.48 (Asptu1_0114323), A. acidus CBS 106 47 (Aspfo1_0139906), A. brasiliensis...”
- “...flavus NRRL 3357 genome [ 44 ] using the protein sequence of A. fumigatus CrzA (XP_750439) and A. nidulans CrzA (XP_663330.1). XP_002381985.1 was identified by protein homology (69% and 67% identity with A. fumigatus CrzA and A. nidulans CrzA, respectively) ( Figure 1 ). AFLA_127920, a...”
- Aspergillus fumigatus calcium-responsive transcription factors regulate cell wall architecture promoting stress tolerance, virulence and caspofungin resistance.
de, PLoS genetics 2019 - GeneRIF: Comparative transcriptomics revealed CrzA and ZipD regulated the expression of shared and unique gene networks, suggesting they participate in both converged and distinct stress response mechanisms. CrzA and ZipD additively promoted calcium stress tolerance.
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NFIA_017790 C2H2 type zinc finger domain protein from Aspergillus fischeri NRRL 181
50% identity, 10% coverage
- Function of crzA in Fungal Development and Aflatoxin Production in Aspergillus flavus
Lim, Toxins 2019 - “...134E9 (Aspwe1_0050154), A. zonatus (Aspzo1_0014943), A. glaucus CBS 516 65 (Aspgl1_0031266), Neosartorya fischeri NRRL 181 (NFIA_017790), Penicillium digitatum Pd1 (XP_014531047.1), Neurospora crassa OR74A (XP_962085), Magnaporthe oryzae 70-15 (MGG_05133), and Fusarium graminearum PH-1 (FGSG_01341). A phylogenetic tree of CrzA homologs (or orthologs) was generated by the Clustal...”
An18g05920 uncharacterized protein from Aspergillus niger
50% identity, 10% coverage
- Function of crzA in Fungal Development and Aflatoxin Production in Aspergillus flavus
Lim, Toxins 2019 - “...oryzae RIB40 (AO090001000491), A. fumigatus Af293 (Afu1g06900), A. nidulans FGSC4 (AN5726), A. niger CBS 513.88 (An18g05920), A. clavatus NRRL 1 (ACLA_027670), A. sydowii (Aspsy1_0149570), A. tubingensis CBS 134.48 (Asptu1_0114323), A. acidus CBS 106 47 (Aspfo1_0139906), A. brasiliensis CBS 101740 (Aspbr1_0197410), A. versicolor CBS 583.65 (Aspve1_0132792), A....”
AO090001000491 No description from Aspergillus oryzae RIB40
50% identity, 10% coverage
- Function of crzA in Fungal Development and Aflatoxin Production in Aspergillus flavus
Lim, Toxins 2019 - “...CrzA homologs identified in 23 fungal species including A. flavus AFL3357 (AFL2T_09134), A. oryzae RIB40 (AO090001000491), A. fumigatus Af293 (Afu1g06900), A. nidulans FGSC4 (AN5726), A. niger CBS 513.88 (An18g05920), A. clavatus NRRL 1 (ACLA_027670), A. sydowii (Aspsy1_0149570), A. tubingensis CBS 134.48 (Asptu1_0114323), A. acidus CBS 106...”
ACLA_027670 C2H2 type zinc finger domain protein from Aspergillus clavatus NRRL 1
50% identity, 10% coverage
- Function of crzA in Fungal Development and Aflatoxin Production in Aspergillus flavus
Lim, Toxins 2019 - “...Af293 (Afu1g06900), A. nidulans FGSC4 (AN5726), A. niger CBS 513.88 (An18g05920), A. clavatus NRRL 1 (ACLA_027670), A. sydowii (Aspsy1_0149570), A. tubingensis CBS 134.48 (Asptu1_0114323), A. acidus CBS 106 47 (Aspfo1_0139906), A. brasiliensis CBS 101740 (Aspbr1_0197410), A. versicolor CBS 583.65 (Aspve1_0132792), A. kawachii (Aspka1_0180272), A. carbonarius ITEM...”
- Aspergillus parasiticus crzA, which encodes calcineurin response zinc-finger protein, is required for aflatoxin production under calcium stress
Chang, International journal of molecular sciences 2008 - “...35 ]. The predicted A. flavus CrzA also matches conserved hypothetical proteins of A. clavatus (ACLA_027670, 69%), A. terreus (ATEG_02928.1, 72%), and A. niger (gw1_10.73, 75%). A. parasiticus gene orthologues commonly share 9899% nucleotide identity to the A. flavus genes. Therefore, the role of A. parasiticus...”
XP_001244584 C2H2 type zinc finger domain-containing protein from Coccidioides immitis RS
50% identity, 10% coverage
- The Crz1/Sp1 transcription factor of Cryptococcus neoformans is activated by calcineurin and regulates cell wall integrity
Lev, PloS one 2012 - “...EAA32849, Neurospora crassa ; EAQ88414, Chg, Chaetomium globosum ; Gz, XP_381517, Gibberella zeae ; Ci, XP_001244584, Coccidioides immitis ; Pn, EAT87393, Phaeosphaeria nodorum ; Dh, CAG84727, Debaryomyces hansenii ; Td, AAZ04388, Torulaspora delbrueckii ; Ag, AAS51722, Ashbya gossypii ; Sc, CAA95889, Saccharomyces cerevisiae ; Kl, CAG99429,...”
TRIATDRAFT_173231 uncharacterized protein from Trichoderma atroviride
50% identity, 11% coverage
- A comprehensive transcription factor and DNA-binding motif resource for the construction of gene regulatory networks in Botrytis cinerea and Trichoderma atroviride
Olivares-Yañez, Computational and structural biotechnology journal 2021 - “...& TF domain Fungi Bcin03g00710; 4497 TRIATDRAFT_78054; 4488 Bcin13g03910; 2153 Zn_Cluster & C2H2 domain TF TRIATDRAFT_173231; 1442 C2H2 domain TF Bcin05g04650; 3609 TRIATDRAFT_173231; 4258 Bcin01g10720; 1977 bZIP TF TRIATDRAFT_173784; 1393 Homeobox domain and Zinc finger C2H2-type Bcin01g08840; 3444 TRIATDRAFT_322580; 4255 Bcin07g06470; 1961 Zn_Cluster & TF domain...”
- “...n.a. Zn_Cluster & Fungal_TF domain TF TRIATDRAFT_222577; 7.2e-17; 55.9 Bcin11g06200 92 n.a. C2H2 domain TF TRIATDRAFT_173231; 1.1e-17; 50.8 Bcin02g09340 91 n.a. Zn_Cluster & C2H2 domain TF TRIATDRAFT_314109; 7.1e-17; 46.7 Bcin04g03280 86 n.a. C2H2 domain TF TRIATDRAFT_161626; 0.00035; 56.5 T. atroviride TF ID Number of targets Name...”
crzA putative transcription factor CrzA from Emericella nidulans (see 2 papers)
50% identity, 11% coverage
- CharProtDB Description: C2H2-type zinc finger transcription factor involved in cation homeostasis; localized to nucleus in the presence of calcium chloride; Source:AspGD
FGSG_01341 hypothetical protein from Fusarium graminearum PH-1
50% identity, 11% coverage
- Functional Characterization of Calcineurin-Responsive Transcription Factors Fg01341 and Fg01350 in Fusarium graminearum
Zhang, Frontiers in microbiology 2020 - “...BLAST search of the F. graminearum genome database 1 . The best candidate gene was FGSG_01341, which shared a 65.8% sequence identity and an E values of 1e-51 with S. cerevisiae Crz1; it was followed by FGSG_01350 (54.4% and an E values of 6.8e-17) and FGSG_13711...”
- “...of partially deduced Crz1 amino acid sequences of S. cerevisiae , BCIN_01g08230, and CNAG_00156 and FGSG_01341, FGSG_01350, and FGSG_13711. The two conserved C2H2 zinc finger domains were labeled. (B) Phylogenetic analysis of FGSG_01341 , FGSG_01350 , and other homologs from other fungal species. The phylogenetic tree...”
- Dynamic network inference and association computation discover gene modules regulating virulence, mycotoxin and sexual reproduction in Fusarium graminearum
Guo, BMC genomics 2020 - “...likely bound by YLR131C in Sc . Interestingly, one of the predicted regulators of module FGSG_01341 is orthologous to YLR131C (E-value=3.34e-17). The YEASTRACT database showed that this conserved TFBS and TF are involved in the biogenesis of cellular components, and this was captured by the GO...”
- Function of crzA in Fungal Development and Aflatoxin Production in Aspergillus flavus
Lim, Toxins 2019 - “...digitatum Pd1 (XP_014531047.1), Neurospora crassa OR74A (XP_962085), Magnaporthe oryzae 70-15 (MGG_05133), and Fusarium graminearum PH-1 (FGSG_01341). A phylogenetic tree of CrzA homologs (or orthologs) was generated by the Clustal Omega package ( https://www.ebi.ac.uk/Tools/msa/clustalo/ ). The tree result was submitted to iTOL ( http://itol.embl.de/ ) to generate...”
- Genomic clustering and co-regulation of transcriptional networks in the pathogenic fungus Fusarium graminearum
Lawler, BMC systems biology 2013 - “...Homeobox/zf-C2H2 1 FG2.11 FGSG_06359 HSF_DNA-bind 1 FG6 FGSG_13911 Myb_DNA-binding 1 FG2.01 FGSG_01298 zf-C2H2 1 FG6 FGSG_01341 zf-C2H2 2 FG1, FG2.10 FGSG_01350 zf-C2H2 2 FG1, FG2.10 FGSG_02743 zf-C2H2 2 FG1, FG2.10 FGSG_06311 zf-C2H2 1 FG6 FGSG_06871 zf-C2H2 4 FG1, FG2.-10, FG2.-11, FG6 FGSG_12970 zf-C2H2 1 FG6 FGSG_08010...”
- Development of a novel multiplex DNA microarray for Fusarium graminearum and analysis of azole fungicide responses
Becher, BMC genomics 2011 - “...225 FGSG_11988 GATGTAATGCTACCTGGAACAC GATGAGACCGATTGTGAGAAC 195 Transcription factors FGSG_00069 GAATCTTCTCCGGCACTCAG TTCTTCACTTCCTTCCGAGATC 139 FGSG_01293 CCCGATATAGTCGAGCCTAAC GGTATTTGTTGCTCCGTTGAC 101 FGSG_01341 ATTCTGGCATGGATGATGAAG CACCAAAGTCACTGGCATATCC 162 FGSG_01669 TTCGACTTCTCACAGCTCAGC TGCCTGCATGTTGTACTGGTC 120 FGSG_05949 TTCGGCAACCATCACTCCTAG TGCTGTTCGTTCTCTCGCACT 100 FGSG_06324 ACAGAGTGTCGAACCAGCAAC GGTTCTCGTGGGATGCTATC 173 FGSG_06810 ATACCCGTCTCATGAACATCG TCGATAACAGCCTTGGCTATG 127 FGSG_09333 CACAGCTCAACGATGCAATG CAAGATAAGCAAGGATGCTGTG 101 FGSG_09349 GCTTGATTGCCCCTCTGAGA GGTTCGCATTCTCCTGGTTC 123 FGSG_10470 AGAGATCACCACGTCCGAAC TGGTGGGTGTAGATGTGGTTC...”
- “...0.0264 Transcription factors FGSG_00069 Zn2Cys6 -2.14 0.0385 -1.81 0.0207 FGSG_01293 Zn2Cys6 2.08 0.0385 1.91 0.0010 FGSG_01341 C2H2 1.62 0.0357 1.92 0.0042 FGSG_01669 Zn2Cys6 3.86 0.0392 3.30 0.0002 FGSG_05949 WING 4.16 0.0385 3.96 < 0.0001 FGSG_06324 Zn2Cys6 1.64 0.0385 1.00 < 0.0001 FGSG_06810 Zn2Cys6 1.70 0.0387 1.35...”
SS1G_04676 hypothetical protein from Sclerotinia sclerotiorum 1980 UF-70
50% identity, 11% coverage
VDAG_03208 transcriptional regulator prz1 from Verticillium dahliae VdLs.17
50% identity, 11% coverage
- VdP5CDH is involved in melanin formation, stress resistance and play a regulatory role in virulence of Verticillium dahliae
Sun, Frontiers in microbiology 2024 - “...genes VdNoxB ( VDAG_09930 ) and VdPls1 ( VDAG_01769 ); the transcriptional activator VdCrz1 ( VDAG_03208 ); follower protein related to the partial assembly of mycelia neck ring VdSep5 ( VDAG_04382 ); the appressorium structure-regulating gene VdCSIN1 ( VDAG_05652 ); Furthermore, two transcription factors, Som1 (...”
- VdGAL4 Modulates Microsclerotium Formation, Conidial Morphology, and Germination To Promote Virulence in Verticillium dahliae
Wen, Microbiology spectrum 2023 - “...) and VdPls1 ( VDAG_01769 ); regulating infection peg development of transcription activator VdCrz1 ( VDAG_03208 ); assembling mycelium neck ring-related secretary protein VdSep5 ( VDAG_04382 ); regulating appressorium formation-related gene VdCSIN1 ( VDAG_05652 ); and plant root adhesion, penetration, and colonization of V. dahliae -related...”
- Two Verticillium dahliae MAPKKKs, VdSsk2 and VdSte11, Have Distinct Roles in Pathogenicity, Microsclerotial Formation, and Stress Adaptation
Yu, mSphere 2019 - “...( VDAG_02340 and VDAG_02341 ), glucan synthesis regulatory protein ( VDAG_08428 ), and VdCrz1 ( VDAG_03208 ). All primers used for these analyses are listed in TableS1 . Pathogenicity and penetration assays. Pathogenicity assays were performed in greenhouses with tobacco seedlings using a root dip method...”
- MADS-Box Transcription Factor VdMcm1 Regulates Conidiation, Microsclerotia Formation, Pathogenicity, and Secondary Metabolism of Verticillium dahliae
Xiong, Frontiers in microbiology 2016 - “...expression levels of several genes (two bZIP genes VDAG_08640 and VDAG_08676, a Crz1 homology gene VDAG_03208, a melanin biosynthesis related gene VDAG_00190, a pyruvate kinase gene VDAG_01206). The results showed that qRT-PCR results and transcriptomic data were well correlated (Figure S4 ). Figure 8 Subcellular localization...”
- “...expression patterns to those detected by mRNA-Seq. VDAG_08640 and VDAG_08676 are bZIP transcription factor genes; VDAG_03208 is a C 2 H 2 transcription factor gene; VDAG_00190 is a gene involved in melanin biosynthesis; VDAG_01206 is a pyruvate kinase gene which catalyzes the generation of pyruvate from...”
- Hyphopodium-Specific VdNoxB/VdPls1-Dependent ROS-Ca2+ Signaling Is Required for Plant Infection by Verticillium dahliae
Zhao, PLoS pathogens 2016 - “...numbers for genes in this study: VdNoxB (VDAG_09930), VdPls1 (VDAG_01769), VdMsb2 (KM032761), VdAR (VDAG_03172), VdCrz1 (VDAG_03208), VdLcc (VDAG_00189), VdMde (VDAG_07056), VdMFS (VDAG_05637), VdRhom (VDAG_08343), VdElf (VDAG_02559), MoPls1 (MGG_12594), MoNox2 (MGG_06559). Supporting Information S1 Fig Construction of knockout mutants Vd noxb and Vd pls1 . A. Schematic...”
MgCRZ1 C2H2 type zinc finger domain-containing protein from Magnaporthe grisea 70-15 (see paper)
MGG_05133 uncharacterized protein from Pyricularia oryzae 70-15
50% identity, 11% coverage
G2XZL7 BcCRZ1, transcription factor Zn, C2H2 from Botryotinia fuckeliana (strain T4)
50% identity, 11% coverage
BCIN_01g08230 Bccrz1 from Botrytis cinerea B05.10
50% identity, 11% coverage
- Functional Characterization of Calcineurin-Responsive Transcription Factors Fg01341 and Fg01350 in Fusarium graminearum
Zhang, Frontiers in microbiology 2020 - “...graminearum . (A) Alignment of partially deduced Crz1 amino acid sequences of S. cerevisiae , BCIN_01g08230, and CNAG_00156 and FGSG_01341, FGSG_01350, and FGSG_13711. The two conserved C2H2 zinc finger domains were labeled. (B) Phylogenetic analysis of FGSG_01341 , FGSG_01350 , and other homologs from other fungal...”
- “...FGSG_10470, FGSG_06311, and FGSG_13711), C. neoformans (CNAG_00156), M. oryzae (MGG_05133), N. crassa (NCU07952), B. cinerea (BCIN_01g08230), A. fumigatus (AFUA_1G06900), and S. cerevisiae (CRZ1). Ca 2 + signals were transmitted by regulating the key transcription factor Crz1 through dephosphorylation and its nuclear translocation. To demonstrate whether Fg06103...”
CRZ2_CANAL / Q59SN6 Transcriptional regulator CRZ2; Calcineurin-responsive zinc finger protein 2 from Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast) (see 4 papers)
45% identity, 15% coverage
- function: Transcription factor that regulates pH-induced filamentation with RIM101. Required for yeast cell adherence to silicone substrate and biofilm formation.
disruption phenotype: Decreases cell adherence to silicone substrate. Blocks biofilm formation.
CRZ2 potential zinc finger protein from Candida albicans (see 2 papers)
45% identity, 15% coverage
- CharProtDB CGD description: Putative transcription factor; zinc finger; similar to S. cerevisiae Crz1p; homozygous crz1, not crz2, null mutation suppresses fluconazole resistance of homozygous cka2 null (defective in CK2 kinase ); Rim101p-downregulated at pH 8
KLF11_MOUSE / Q8K1S5 Krueppel-like factor 11; TGFB-inducible early growth response protein 2b; Transforming growth factor-beta-inducible early growth response protein 3; TGFB-inducible early growth response protein 3; TIEG-3 from Mus musculus (Mouse) (see 4 papers)
NP_848134 Krueppel-like factor 11 from Mus musculus
43% identity, 15% coverage
- function: Transcription factor. Activates the epsilon- and gamma-globin gene promoters and, to a much lower degree, the beta-globin gene and represses promoters containing SP1-like binding sites inhibiting cell growth (By similarity). Represses transcription of SMAD7 which enhances TGF-beta signaling. Induces apoptosis.
subunit: Interacts with SIN3A.
disruption phenotype: Mice breed normally and are fertile. Hematopoiesis at all stages of development is normal and there is no effect on globin gene expression or longevity. - Host immunity and KLF 11 deficiency together promote fibrosis in a mouse model of endometriosis.
Grande, Biochimica et biophysica acta. Molecular basis of disease 2023 (PubMed)- GeneRIF: Host immunity and KLF 11 deficiency together promote fibrosis in a mouse model of endometriosis.
- KLF11 deficiency enhances chemokine generation and fibrosis in murine unilateral ureteral obstruction.
De, PloS one 2022 - GeneRIF: KLF11 deficiency enhances chemokine generation and fibrosis in murine unilateral ureteral obstruction.
- Genetic deletion of Krüppel-like factor 11 aggravates traumatic brain injury.
Zhou, Journal of neuroinflammation 2022 - GeneRIF: Genetic deletion of Kruppel-like factor 11 aggravates traumatic brain injury.
- Sclerostin antibody treatment rescues the osteopenic bone phenotype of TGFβ inducible early gene-1 knockout female mice.
Gingery, Journal of cellular physiology 2020 - GeneRIF: Sclerostin antibody treatment rescues the osteopenic bone phenotype of TGFbeta inducible early gene-1 knockout female mice.
- Endothelium-targeted overexpression of Krüppel-like factor 11 protects the blood-brain barrier function after ischemic brain injury.
Zhang, Brain pathology (Zurich, Switzerland) 2020 - GeneRIF: Endothelium-targeted overexpression of Kruppel-like factor 11 protects the blood-brain barrier function after ischemic brain injury.
- KLF11 (Krüppel-Like Factor 11) Inhibits Arterial Thrombosis via Suppression of Tissue Factor in the Vascular Wall.
Liang, Arteriosclerosis, thrombosis, and vascular biology 2019 - GeneRIF: Vascular smooth muscle cell-specific Klf11 knockout mice exhibited significantly reduced occlusion time.KLF11 is a novel transcriptional suppressor of F3 in vascular smooth muscle cells. KLF11 downregulates F3 at the transcriptional level as determined by reporter and chromatin immunoprecipitation assays.
- Genetic Deletion of Krüppel-Like Factor 11 Aggravates Ischemic Brain Injury.
Tang, Molecular neurobiology 2018 - GeneRIF: KLF11 acts as a novel protective factor in ischemic stroke.
- KLF11 is an Epigenetic Mediator of DRD2/Dopaminergic Signaling in Endometriosis.
Richards, Reproductive sciences (Thousand Oaks, Calif.) 2017 (PubMed)- GeneRIF: Consistent with loss of Klf11-mediated activation, lesions in Klf11-/- animals were associated with progressive fibrosis and decreased Drd2 expression.
- More
NP_001177179 Krueppel-like factor 8 from Sus scrofa
43% identity, 20% coverage
NP_001311034 Krueppel-like factor 8 isoform 6 from Homo sapiens
43% identity, 20% coverage
KLF8_HUMAN / O95600 Krueppel-like factor 8; Basic krueppel-like factor 3; Zinc finger protein 741 from Homo sapiens (Human) (see 4 papers)
43% identity, 20% coverage
- function: Transcriptional repressor and activator. Binds to CACCC-boxes promoter elements. Also binds the GT-box of cyclin D1 promoter and mediates cell cycle progression at G(1) phase as a downstream target of focal adhesion kinase (FAK).
subunit: Interacts with corepressor CtBP2. Interacts with PIAS1, PIAS2, and PIAS4; the interaction with each ligase sumoylates KLF8. - SP and KLF Transcription Factors in Digestive Physiology and Diseases.
Kim, Gastroenterology 2017 - “...KLF1 (Q13351), KLF2 (Q9Y5W3), KLF3 (P57682), KLF4 (Q43474), KLF5 (Q13887), KLF6 (Q99612), KLF7 (O75840), KLF8 (O95600), KLF9 (Q13886), KLF10 (Q13118), KLF11 (O14901), KLF12 (Q9Y4X4), KLF13 (Q9Y2Y9), KLF14 (Q8TD49), KLF15 (Q9UIH9), KLF16 (Q9BXK1), and KLF17 (Q5JT82). Figure 2 Post-translational Modifications and Co-factors That Interact With SP and...”
- Krüppel-like factors in cancer progression: three fingers on the steering wheel.
Limame, Oncotarget 2014 - “...ST12, GBF AF284036 Q99612 283 31.9 KLF7 U-KLF O75840 302 33.4 KLF8 BKLF3, ZNF741 NM_007250 O95600 359 39.3 KLF9 BTEB, BTEB1 NM_001206 Q13886 244 27.2 KLF10 TIEG, TIEG1, EGR NM_005655 Q13118 480 52.6 KLF11 F-KLF, TIEG2, MODY7 O14901 512 55.1 KLF12 AP2rep, HSPC122 Q9Y4X4 402 44.2...”
- A survey of well conserved families of C2H2 zinc-finger genes in Daphnia
Seetharam, BMC genomics 2010 - “...(Dappu-27999) scaffold_1:1214746-1215144 KLF6 (Q99612) BTEB2 (NP_572185) LUNA (Dappu-310992) scaffold_3:2311937-2324470 KLF7 (O75840) CABUT (Dappu-312628) scaffold_6:1962325-1965508 KLF8 (O95600) KLF9 (Dappu-315814) scaffold_15:985228-986723 KLF9 (Q13886) BTEB2 (Dappu-50068) scaffold_21:551156-551927 KLF10 (Q13118) KLF1E (Dappu-262162) scaffold_164:255538-257421 KLF11 (O14901) KLF12 (NP_009180) KLF13 (NP_057079) KLF14 (Q8TD94) KLF15 (Q9UIH9) KLF16 (Q9BXK1) KLF17 (Q5JT82) The updated list...”
NP_722636 cabut, isoform A from Drosophila melanogaster
42% identity, 17% coverage
- The Krüppel-like factor Cabut has cell cycle regulatory properties similar to E2F1.
Zhang, Proceedings of the National Academy of Sciences of the United States of America 2021 - GeneRIF: The Kruppel-like factor Cabut has cell cycle regulatory properties similar to E2F1.
- A stress-responsive miRNA regulates BMP signaling to maintain tissue homeostasis.
Mukherjee, Proceedings of the National Academy of Sciences of the United States of America 2021 - GeneRIF: A stress-responsive miRNA regulates BMP signaling to maintain tissue homeostasis.
- Cabut/dTIEG associates with the transcription factor Yorkie for growth control.
Ruiz-Romero, EMBO reports 2015 - GeneRIF: Cbt is a novel partner of Yki that is required as a transcriptional co-activator in growth control.
- The transcription factor Cabut coordinates energy metabolism and the circadian clock in response to sugar sensing.
Bartok, The EMBO journal 2015 - GeneRIF: perturbation of CBT levels leads to deregulation of the circadian transcriptome and circadian behavioral patterns.
- Transcriptional activity and nuclear localization of Cabut, the Drosophila ortholog of vertebrate TGF-β-inducible early-response gene (TIEG) proteins.
Belacortu, PloS one 2012 - GeneRIF: characterization of the molecular mechanisms of Cbt-mediated transcriptional control as well as of Cbt nuclear import
- Cabut, a C2H2 zinc finger transcription factor, is required during Drosophila dorsal closure downstream of JNK signaling.
Muñoz-Descalzo, Developmental biology 2005 (PubMed)- GeneRIF: Cbt functions downstream of Jun regulating dpp expression in the leading edge cells during dorsal closure
- Expression of Drosophila Cabut during early embryogenesis, dorsal closure and nervous system development.
Belacortu, Gene expression patterns : GEP (PubMed)- GeneRIF: Cabut is localized on the surface of mitotic chromosomes at all mitotic phases
KLF10_HUMAN / Q13118 Krueppel-like factor 10; EGR-alpha; Transforming growth factor-beta-inducible early growth response protein 1; TGFB-inducible early growth response protein 1; TIEG-1 from Homo sapiens (Human) (see 3 papers)
NP_005646 Krueppel-like factor 10 isoform a from Homo sapiens
43% identity, 15% coverage
- function: Transcriptional repressor which binds to the consensus sequence 5'-GGTGTG-3'. Plays a role in the regulation of the circadian clock; binds to the GC box sequence in the promoter of the core clock component ARTNL/BMAL1 and represses its transcriptional activity. Regulates the circadian expression of genes involved in lipogenesis, gluconeogenesis, and glycolysis in the liver. Represses the expression of PCK2, a rate-limiting step enzyme of gluconeogenesis (By similarity). May play a role in the cell cycle regulation.
- Blood Plasma Circulating DNA-Protein Complexes: Involvement in Carcinogenesis and Prospects for Liquid Biopsy of Breast Cancer.
Shefer, Journal of personalized medicine 2023 - “...P50454 P51665 P55010 P60059 P60608 P62314 Q01081 Q02108 Q03060 Q03252 Q05215 Q06416 Q13033 Q13111 Q13114 Q13118 Q13243 Q13454 Q14332 Q15391 Q15404 Q15629 Q15645 Q16206 Q3YEC7 Q5T447 Q5T4B2 Q5VIR6 Q69YI7 Q6NXG1 Q6PCT2 Q6STE5 Q75V66 Q7LGA3 Q7Z422 Q7Z5R6 Q7Z6I6 Q7Z7J5 Q8IV76 Q8IX30 Q8N1L4 Q8NEC5 Q8WU08 Q92623 Q96AQ8 Q96HJ3...”
- Deciphering the mechanoresponsive role of β-catenin in keratoconus epithelium.
Amit, Scientific reports 2020 - “...Q5T5U3 32 Epithelial-stromal interaction protein 1 EPISTI1 37 Q96J88 32 Krueppel-like factor 10 KLF10 52 Q13118 32 CXC chemokine receptor type 6 CXCR6 39 O00574 32 Tenascin C TNC 225 Q99857 32 Chondroitin sulfate N-acetylgalactosaminyltransferase CSGALNACT1 61 Q8TDX6 31 G1/S-specific cyclin-E2 CCNE2 48 O96020 30 Peroxisomal...”
- Transcriptome Analysis and Differential Gene Expression on the Testis of Orange Mud Crab, Scylla olivacea, during Sexual Maturation
Waiho, PloS one 2017 - “...Charybdis japonica (Asian paddle crab) 80 3e-18 Ref_Crab_Transcript_23777_903 Growth and development related Krueppel-like factor 10 Q13118 Homo sapiens (Human) 100 2e-79 Ref_Crab_Transcript_160024_379 Growth factor receptor-bound protein 2 U6DGZ9 Neovison vison (American mink) 100 4e-83 Ref_Crab_Transcript_151979_370 Transforming growth factor-beta regulator I H9B3Y8 Scylla paramamosain (Green mud crab)...”
- SP and KLF Transcription Factors in Digestive Physiology and Diseases.
Kim, Gastroenterology 2017 - “...KLF3 (P57682), KLF4 (Q43474), KLF5 (Q13887), KLF6 (Q99612), KLF7 (O75840), KLF8 (O95600), KLF9 (Q13886), KLF10 (Q13118), KLF11 (O14901), KLF12 (Q9Y4X4), KLF13 (Q9Y2Y9), KLF14 (Q8TD49), KLF15 (Q9UIH9), KLF16 (Q9BXK1), and KLF17 (Q5JT82). Figure 2 Post-translational Modifications and Co-factors That Interact With SP and KLF Proteins SP/KLF protein...”
- Krüppel-like factors in cancer progression: three fingers on the steering wheel.
Limame, Oncotarget 2014 - “...O95600 359 39.3 KLF9 BTEB, BTEB1 NM_001206 Q13886 244 27.2 KLF10 TIEG, TIEG1, EGR NM_005655 Q13118 480 52.6 KLF11 F-KLF, TIEG2, MODY7 O14901 512 55.1 KLF12 AP2rep, HSPC122 Q9Y4X4 402 44.2 KLF13 BTEB3, NSLP1, RFLAT-1 NM_015995 Q9Y2Y9 288 31.2 KLF14 BTEB5, SP6, EPFN DQ534757 Q8TD94 323...”
- A survey of well conserved families of C2H2 zinc-finger genes in Daphnia
Seetharam, BMC genomics 2010 - “...(O75840) CABUT (Dappu-312628) scaffold_6:1962325-1965508 KLF8 (O95600) KLF9 (Dappu-315814) scaffold_15:985228-986723 KLF9 (Q13886) BTEB2 (Dappu-50068) scaffold_21:551156-551927 KLF10 (Q13118) KLF1E (Dappu-262162) scaffold_164:255538-257421 KLF11 (O14901) KLF12 (NP_009180) KLF13 (NP_057079) KLF14 (Q8TD94) KLF15 (Q9UIH9) KLF16 (Q9BXK1) KLF17 (Q5JT82) The updated list of SP and KLF homologs with their accession numbers found...”
- Gene expression pattern in Caco-2 cells following rotavirus infection
Cuadras, Journal of virology 2002 - “...2.6 2.3 2.4 Q9BYH8 Q03060 6.4 5.4 Q99612 4.3 2.8 Q13118 O00472 2.9 2.9 P05455 P20694 O76080 ZNF313 P35638 P41738 Q64127 Q9UKY1 P13941 P50539 P24468 2.4 2.1 2.3...”
- New Insights into the Role of KLF10 in Tissue Fibrosis.
Yaseen, International journal of molecular sciences 2024 - GeneRIF: New Insights into the Role of KLF10 in Tissue Fibrosis.
- CircITGA7 regulates malignant phenotypes in bladder cancer cells via targeting miR-330-3p/KLF10 axis.
Yang, The Kaohsiung journal of medical sciences 2024 (PubMed)- GeneRIF: CircITGA7 regulates malignant phenotypes in bladder cancer cells via targeting miR-330-3p/KLF10 axis.
- Krüppel-like factor 10 protects against metabolic dysfunction-associated steatohepatitis by regulating HNF4α-mediated metabolic pathways.
Pan, Metabolism: clinical and experimental 2024 - GeneRIF: Kruppel-like factor 10 protects against metabolic dysfunction-associated steatohepatitis by regulating HNF4alpha-mediated metabolic pathways.
- Transcription factor AP-2 gamma/Krüppel-like factor 10 axis is involved in miR-3656-related dysfunction of endothelial cells in hypertension.
Ren, Journal of hypertension 2023 (PubMed)- GeneRIF: Transcription factor AP-2 gamma/Kruppel-like factor 10 axis is involved in miR-3656-related dysfunction of endothelial cells in hypertension.
- KLF10 knockdown negatively regulates CTRP3 to improve OGD/R-induced brain microvascular endothelial cell injury and barrier dysfunction through Nrf2/HO-1 signaling pathway.
Zeng, Tissue & cell 2023 (PubMed)- GeneRIF: KLF10 knockdown negatively regulates CTRP3 to improve OGD/R-induced brain microvascular endothelial cell injury and barrier dysfunction through Nrf2/HO-1 signaling pathway.
- Krüppel-like factor 10 modulates stem cell phenotypes of pancreatic adenocarcinoma by transcriptionally regulating notch receptors.
Tsai, Journal of biomedical science 2023 - GeneRIF: Kruppel-like factor 10 modulates stem cell phenotypes of pancreatic adenocarcinoma by transcriptionally regulating notch receptors.
- A TGF-β/KLF10 signaling axis regulates atrophy-associated genes to induce muscle wasting in pancreatic cancer.
Dasgupta, Proceedings of the National Academy of Sciences of the United States of America 2023 - GeneRIF: A TGF-beta/KLF10 signaling axis regulates atrophy-associated genes to induce muscle wasting in pancreatic cancer.
- Kruppel like factor 10 up-regulates PDZ and LIM domain containing protein 2 via nuclear factor kappa-B pathway to inhibit proliferation and inflammatory of fibroblastoid synovial cell in rheumatoid arthritis.
Wang, Bioengineered 2022 - GeneRIF: Kruppel like factor 10 up-regulates PDZ and LIM domain containing protein 2 via nuclear factor kappa-B pathway to inhibit proliferation and inflammatory of fibroblastoid synovial cell in rheumatoid arthritis.
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KLF11_HUMAN / O14901 Krueppel-like factor 11; Transforming growth factor-beta-inducible early growth response protein 2; TGFB-inducible early growth response protein 2; TIEG-2 from Homo sapiens (Human) (see 4 papers)
NP_003588 Krueppel-like factor 11 isoform a from Homo sapiens
43% identity, 15% coverage
- function: Transcription factor (PubMed:10207080, PubMed:9748269). Activates the epsilon- and gamma-globin gene promoters and, to a much lower degree, the beta-globin gene and represses promoters containing SP1-like binding inhibiting cell growth (PubMed:10207080, PubMed:16131492, PubMed:9748269). Represses transcription of SMAD7 which enhances TGF-beta signaling (By similarity). Induces apoptosis (By similarity).
subunit: Interacts with SIN3A. - SP and KLF Transcription Factors in Digestive Physiology and Diseases.
Kim, Gastroenterology 2017 - “...KLF4 (Q43474), KLF5 (Q13887), KLF6 (Q99612), KLF7 (O75840), KLF8 (O95600), KLF9 (Q13886), KLF10 (Q13118), KLF11 (O14901), KLF12 (Q9Y4X4), KLF13 (Q9Y2Y9), KLF14 (Q8TD49), KLF15 (Q9UIH9), KLF16 (Q9BXK1), and KLF17 (Q5JT82). Figure 2 Post-translational Modifications and Co-factors That Interact With SP and KLF Proteins SP/KLF protein is illustrated...”
- Krüppel-like factors in cancer progression: three fingers on the steering wheel.
Limame, Oncotarget 2014 - “...Q13886 244 27.2 KLF10 TIEG, TIEG1, EGR NM_005655 Q13118 480 52.6 KLF11 F-KLF, TIEG2, MODY7 O14901 512 55.1 KLF12 AP2rep, HSPC122 Q9Y4X4 402 44.2 KLF13 BTEB3, NSLP1, RFLAT-1 NM_015995 Q9Y2Y9 288 31.2 KLF14 BTEB5, SP6, EPFN DQ534757 Q8TD94 323 33.1 KLF15 K-KLF NM_014079 Q9UIH9 416 44...”
- A survey of well conserved families of C2H2 zinc-finger genes in Daphnia
Seetharam, BMC genomics 2010 - “...(O95600) KLF9 (Dappu-315814) scaffold_15:985228-986723 KLF9 (Q13886) BTEB2 (Dappu-50068) scaffold_21:551156-551927 KLF10 (Q13118) KLF1E (Dappu-262162) scaffold_164:255538-257421 KLF11 (O14901) KLF12 (NP_009180) KLF13 (NP_057079) KLF14 (Q8TD94) KLF15 (Q9UIH9) KLF16 (Q9BXK1) KLF17 (Q5JT82) The updated list of SP and KLF homologs with their accession numbers found in Homo sapiens (Build 36.3...”
- Maturity-onset Diabetes of the Young Type 7 (MODY7) and the Krüppellike Factor 11 Mutation (KLF11). A Review.
Mancera-Rincón, Current diabetes reviews 2024 (PubMed)- GeneRIF: Maturity-onset Diabetes of the Young Type 7 (MODY7) and the Kruppellike Factor 11 Mutation (KLF11). A Review.
- Maturity-onset diabetes of the young type 7 (MODY7) and mutation in the Krüppel-like transcription factor 11 (KLF11) gene.
Wang, QJM : monthly journal of the Association of Physicians 2024 - GeneRIF: Maturity-onset diabetes of the young type 7 (MODY7) and mutation in the Kruppel-like transcription factor 11 (KLF11) gene.
- Aberrant cell adhesiveness due to DNA hypermethylation of KLF11 in papillary urothelial carcinomas.
Tsumura, Experimental and molecular pathology 2024 (PubMed)- GeneRIF: Aberrant cell adhesiveness due to DNA hypermethylation of KLF11 in papillary urothelial carcinomas.
- Genetic and Functional Analyses of the Novel KLF11 Pro193Thr Variant in a Three-Generation Family with MODY7.
Guan, Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme 2023 (PubMed)- GeneRIF: Genetic and Functional Analyses of the Novel KLF11 Pro193Thr Variant in a Three-Generation Family with MODY7.
- KLF11 regulates lung adenocarcinoma ferroptosis and chemosensitivity by suppressing GPX4.
Zhao, Communications biology 2023 - GeneRIF: KLF11 regulates lung adenocarcinoma ferroptosis and chemosensitivity by suppressing GPX4.
- KLF11 Protects against Venous Thrombosis via Suppressing Tissue Factor Expression.
Liang, Thrombosis and haemostasis 2022 - GeneRIF: KLF11 Protects against Venous Thrombosis via Suppressing Tissue Factor Expression.
- Evaluation of Evidence for Pathogenicity Demonstrates That BLK, KLF11, and PAX4 Should Not Be Included in Diagnostic Testing for MODY.
Laver, Diabetes 2022 - GeneRIF: Evaluation of Evidence for Pathogenicity Demonstrates That BLK, KLF11, and PAX4 Should Not Be Included in Diagnostic Testing for MODY.
- KLF11 promotes the progression of glioma via regulating Holliday junction recognition protein.
Li, Cell biology international 2022 (PubMed)- GeneRIF: KLF11 promotes the progression of glioma via regulating Holliday junction recognition protein.
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XP_017173992 Krueppel-like factor 8 isoform X3 from Mus musculus
43% identity, 20% coverage
- Krüppel-like transcription factor 8 (Klf8) is expressed and active in the neurons of the mouse brain.
Dobrivojević, Gene 2015 (PubMed)- GeneRIF: Klf8 is highly expressed in various regions of the mouse brain and in particular in the neurons, where it was localized in the cell nuclei.
- Generation of mice deficient in both KLF3/BKLF and KLF8 reveals a genetic interaction and a role for these factors in embryonic globin gene silencing.
Funnell, Molecular and cellular biology 2013 - GeneRIF: KLF3 and KLF8 have overlapping roles in vivo and participate in the silencing of embryonic globin expression during development.
- Krüppel-like factor KLF8 plays a critical role in adipocyte differentiation.
Lee, PloS one 2012 - GeneRIF: KLF8 is a key component of the transcription factor network that controls terminal differentiation during adipogenesis.
- Identification of poly (ADP-ribose) polymerase-1 (PARP-1) as a novel Kruppel-like factor 8-interacting and -regulating protein.
Lu, The Journal of biological chemistry 2011 - GeneRIF: PARP-1 as a novel KLF8-binding and -regulating protein and provided new insights into the mechanisms underlying the regulation of KLF8 nuclear localization, stability, and functions.
- KLF8 recruits the p300 and PCAF co-activators to its amino terminal activation domain to activate transcription.
Urvalek, Cell cycle (Georgetown, Tex.) 2010 - GeneRIF: These results identified the KLF8 activation domain located between residues 101-260 where the well-conserved Q118 and Q248 are essential for recruiting p300 and PCAF to activate target gene transcription.
- A unique sequence in the N-terminal regulatory region controls the nuclear localization of KLF8 by cooperating with the C-terminal zinc-fingers.
Mehta, Cell research 2009 (PubMed)- GeneRIF: KLF8 has two N terminal regulatory regions, one surrounding S165 and K171 and the other being two tandem ZFs, which are critical for the regulation of KLF8 nuclear localization and its cellular functions
- A network of Krüppel-like Factors (Klfs). Klf8 is repressed by Klf3 and activated by Klf1 in vivo.
Eaton, The Journal of biological chemistry 2008 - GeneRIF: Klf8 is repressed by Klf3 and activated by Klf1 in vivo.
- Sumoylation delimits KLF8 transcriptional activity associated with the cell cycle regulation.
Wei, The Journal of biological chemistry 2006 (PubMed)- GeneRIF: sumoylation of KLF8 negatively regulates its transcriptional activity and cellular functions
B7ZAX4 cDNA, FLJ79338, highly similar to Krueppel-like factor 11 from Homo sapiens
43% identity, 16% coverage
KLF10_RAT / O08876 Krueppel-like factor 10; Transforming growth factor-beta-inducible early growth response protein 1; TGFB-inducible early growth response protein 1; TIEG-1; Zinc finger transcription factor homolog CPG20 from Rattus norvegicus (Rat) (see paper)
NP_112397 Krueppel-like factor 10 from Rattus norvegicus
43% identity, 15% coverage
KLF10_MOUSE / O89091 Krueppel-like factor 10; GDNF-inducible factor; Transcription factor GIF; mGIF; Transforming growth factor-beta-inducible early growth response protein 1; TGFB-inducible early growth response protein 1; TIEG-1 from Mus musculus (Mouse) (see 3 papers)
43% identity, 15% coverage
- function: Transcriptional repressor which binds to the consensus sequence 5'-GGTGTG-3'. May play a role in the cell cycle regulation (By similarity). Plays a role in the regulation of the circadian clock; binds to the GC box sequence in the promoter of the core clock component ARTNL/BMAL1 and represses its transcriptional activity. Regulates the circadian expression of genes involved in lipogenesis, gluconeogenesis, and glycolysis in the liver. Represses the expression of PCK2, a rate-limiting step enzyme of gluconeogenesis.
disruption phenotype: Male mice display postprandial and fasting hyperglycemia while female mice are normoglycemic but display higher plasma triglycerides. - SMAD 8 binding to mice Msx1 basal promoter is required for transcriptional activation.
Binato, The Biochemical journal 2006 - Cytokine-related genes identified from the RIKEN full-length mouse cDNA data set
Brusic, Genome research 2003 - “...identity) to the human, than to mouse TIEG2 (O89091) (74% identity). TIEG2 is ubiquitously expressed in human tissues, enriched in pancreas and muscle (Cook...”
KLF17_HUMAN / Q5JT82 Krueppel-like factor 17; Zinc finger protein 393 from Homo sapiens (Human) (see paper)
43% identity, 19% coverage
- function: Transcription repressor that binds to the promoter of target genes and prevents their expression. Acts as a negative regulator of epithelial-mesenchymal transition and metastasis in breast cancer. Specifically binds the 5'-CACCC-3' sequence in the promoter of ID1, a key metastasis regulator in breast cancer, and repress its expression. May be a germ cell-specific transcription factor that plays important roles in spermatid differentiation and oocyte development (By similarity).
- SP and KLF Transcription Factors in Digestive Physiology and Diseases.
Kim, Gastroenterology 2017 - “...(Q13118), KLF11 (O14901), KLF12 (Q9Y4X4), KLF13 (Q9Y2Y9), KLF14 (Q8TD49), KLF15 (Q9UIH9), KLF16 (Q9BXK1), and KLF17 (Q5JT82). Figure 2 Post-translational Modifications and Co-factors That Interact With SP and KLF Proteins SP/KLF protein is illustrated as a bar with the three zinc fingers identified near the carboxyl terminus....”
- Krüppel-like factors in cancer progression: three fingers on the steering wheel.
Limame, Oncotarget 2014 - “...NM_014079 Q9UIH9 416 44 KLF16 BTEB4, NSLP2, DRRF NM_031918 Q9BXK1 252 25.4 KLF17 ZNF393 NM_173484 Q5JT82 389 42.6 Ablebbreviations: AP2rep AP2 repressor, B basic, BCD B-cell derived protein, BTEB basic transcription element binding, C colon, COBEP core promoter element binding protein, CPBP core promoter binding protein,...”
- A survey of well conserved families of C2H2 zinc-finger genes in Daphnia
Seetharam, BMC genomics 2010 - “...(Dappu-262162) scaffold_164:255538-257421 KLF11 (O14901) KLF12 (NP_009180) KLF13 (NP_057079) KLF14 (Q8TD94) KLF15 (Q9UIH9) KLF16 (Q9BXK1) KLF17 (Q5JT82) The updated list of SP and KLF homologs with their accession numbers found in Homo sapiens (Build 36.3 downloaded from ftp://ftp.ncbi.nih.gov/genomes/H_sapiens/ARCHIVE/BUILD.36.3 ) Drosophila melanogaster (Build 4.1, downloaded from ftp://ftp.ncbi.nih.gov/genomes/Drosophila_melanogaster/RELEASE_4.1/ ),...”
XP_417013 Krueppel-like factor 5 from Gallus gallus
46% identity, 16% coverage
XP_004012234 Krueppel-like factor 5 from Ovis aries
46% identity, 16% coverage
XP_011539002 Krueppel-like factor 17 isoform X1 from Homo sapiens
43% identity, 21% coverage
- KLF17 promotes human naive pluripotency through repressing MAPK3 and ZIC2.
Wang, Science China. Life sciences 2022 (PubMed)- GeneRIF: KLF17 promotes human naive pluripotency through repressing MAPK3 and ZIC2.
- Precision hyperthermia-induced miRNA-409-3p upregulation inhibits migration, invasion, and EMT of gastric cancer cells by targeting KLF17.
Feng, Biochemical and biophysical research communications 2021 (PubMed)- GeneRIF: Precision hyperthermia-induced miRNA-409-3p upregulation inhibits migration, invasion, and EMT of gastric cancer cells by targeting KLF17.
- KLF17 promotes human naïve pluripotency but is not required for its establishment.
Lea, Development (Cambridge, England) 2021 - GeneRIF: KLF17 promotes human naive pluripotency but is not required for its establishment.
- Effect of KLF17 overexpression on epithelial-mesenchymal transition of gastric cancer cells.
Li, The Journal of international medical research 2021 - GeneRIF: Effect of KLF17 overexpression on epithelial-mesenchymal transition of gastric cancer cells.
- Overexpression of KLF17 Predicts a Favorable Prognosis in Patients with Oral Squamous Cell Carcinoma: A Retrospective Study.
Lee, Medicina (Kaunas, Lithuania) 2020 - GeneRIF: Overexpression of KLF17 Predicts a Favorable Prognosis in Patients with Oral Squamous Cell Carcinoma: A Retrospective Study.
- Krüppel-like factor 17 upregulates uterine corin expression and promotes spiral artery remodeling in pregnancy.
Wang, Proceedings of the National Academy of Sciences of the United States of America 2020 - GeneRIF: Kruppel-like factor 17 upregulates uterine corin expression and promotes spiral artery remodeling in pregnancy.
- Melatonin inhibits breast cancer cell invasion through modulating DJ-1/KLF17/ID-1 signaling pathway.
El-Sokkary, Journal of cellular biochemistry 2019 (PubMed)- GeneRIF: The above data show that normal levels of melatonin may help in preventing breast cancer metastasis through inhibiting DJ-1/KLF17/ID-1 signaling pathway. The combination of melatonin and taxol is a potent candidate against breast cancer metastasis, better than using melatonin or taxol as a single drug
- Clinical significance and biological role of KLF17 as a tumour suppressor in colorectal cancer.
Jiang, Oncology reports 2019 (PubMed)- GeneRIF: Results revealed that KLF17 expression was abnormally decreased in colorectal cancer (CRC) and associated with lymph node metastasis and unfavorable overall survival. Moreover, ectopic KLF17 expression suppressed CRC cell growth and invasion in vitro and in vivo. In addition, the downregulation of KLF17 was associated with the hypermethylation of the CpG nucleotides on the KLF17 promoter.
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KLF3_MOUSE / Q60980 Krueppel-like factor 3; Basic krueppel-like factor; CACCC-box-binding protein BKLF; TEF-2 from Mus musculus (Mouse) (see 3 papers)
NP_032479 Krueppel-like factor 3 from Mus musculus
45% identity, 21% coverage
NP_001099212 Krueppel-like factor 3 from Rattus norvegicus
45% identity, 21% coverage
KLF5_HUMAN / Q13887 Krueppel-like factor 5; Basic transcription element-binding protein 2; BTE-binding protein 2; Colon krueppel-like factor; GC-box-binding protein 2; Intestinal-enriched krueppel-like factor; Transcription factor BTEB2 from Homo sapiens (Human) (see 4 papers)
46% identity, 16% coverage
- function: Transcription factor that binds to GC box promoter elements. Activates the transcription of these genes
subunit: Interacts with WWP1. Interacts with ANP32B; this interaction induces promoter region-specific histone incorporation and inhibition of histone acetylation by ANP32B. - The role of HR-HPV integration in the progression of premalignant lesions into different cancer types.
Catalán-Castorena, Heliyon 2024 - “...16 APOT analysis E1, E2 and E5 Introns, exons, and intergenic regions MYC (P01106) KLF5 (Q13887) KLF12 (Q9Y4X4) HIF1A (Q16665) CASZ1 (Q86V15) GPN(Q9HCN4) MBD5 (Q9P267) ORC2 (Q13416) PARD3B (Q8TEW8) ERBB4 (Q15303) FHIT (P49789) MECOM (Q03112) ATP11B (Q9Y2G3) CLDN1 (O95832) IL8 (P10145) DUX4L2 (P0CJ85) SLC29A1 (Q99808) RUNX2...”
- “...LCR Introns, exons, flanking regions of genes POU5F1B (Q06416) FHIT ( P49789) KLF12 (Q9Y4X4) KLF5 (Q13887) LRP1B (Q9NZR2) LEPREL1 (Q8IVL5) HMGA2 (P52926) DLG2 (Q15700) SEMA3D (O95025) MYC (P01106) [ 156 ] 72 cervical cancer biopsies with HR-HPV (16, 18, 33, 45, 51, 45, 68) Capture-HPV-NGS E1,...”
- Aqueous Extracts of Ocimum gratissimum Sensitize Hepatocellular Carcinoma Cells to Cisplatin through BRCA1 Inhibition.
Chen, International journal of molecular sciences 2024 - “...repeat subunit B Homeobox protein SIX4 0.01 0.01 Q9UIU6 SIX4 Homeobox protein SIX4 0.01 0.01 Q13887 KLF5 Krueppel-like factor 5 0.01 0.01 Q6PEV8 FAM199X Protein FAM199X 0.01 0.01 P21741 MDK Midkine 0.28 0.01 Q6ZRY4 RBPMS2 RNA-binding protein with multiple splicing 2 0.37 0.12 O00212 RHOD Rho-related...”
- Repurposing fluphenazine as an autophagy modulator for treating liver cancer.
Su, Heliyon 2023 - “...93.99% Serotonin transporter P31645 92.49% 95.51% Tyrosine-protein kinase YES P07947 92.03% 83.14% Kruppel-like factor 5 Q13887 91.9% 86.33% Table 3 Indications of some predicted targets. Table 3 Target Name Indication Probability Model accuracy HERG Ovarian cancer 99.19% 89.76% Histone deacetylase 8 Solid tumour/cancer 92.87% 93.99% DNA-(apurinic...”
- Aryl-hydrocarbon receptor-interacting protein regulates tumorigenic and metastatic properties of colorectal cancer cells driving liver metastasis
Solís-Fernández, British journal of cancer 2022 - “...CDH17 Up Q13459 Unconventional myosin-IXb MYO9B Up Q13887 Krueppel-like factor 5 KLF5 Up Q53H12 Acylglycerol kinase, mitochondrial AGK Up Q8N3X1 Formin-binding...”
- Antiproliferative Copper(II) Complexes Bearing Mixed Chelating Ligands: Structural Characterization, ROS Scavenging, In Silico Studies, and Anti-Melanoma Activity.
Olar, Pharmaceutics 2022 - “...Q9NUW8 6N0D 95 71 Transcription intermediary factor 1-alpha O15164 4YBM 92 96 Kruppel-like factor 5 Q13887 Not Available 90 86 Compound (2) Pregnane X receptor O75469 6TFI 94 95 Transcription intermediary factor 1-alpha O15164 4YBM 93 96 Kruppel-like factor 5 Q13887 Not Available 92 86 Monoamine...”
- “...4YBM 93 96 Nuclear factor NF-kappa-B p105 subunit P19838 1SVC 93 96 Kruppel-like factor 5 Q13887 Not Available 91 86 Compound (4) Tyrosyl-DNA phosphodiesterase 1 Q9NUW8 6N0D 96 71 HERG Q12809 5VA1 96 90 Transcription intermediary factor 1-alpha O15164 4YBM 96 96 Kruppel-like factor 5 Q13887...”
- Licorice extract inhibits growth of non-small cell lung cancer by down-regulating CDK4-Cyclin D1 complex and increasing CD8+ T cell infiltration
Zhu, Cancer cell international 2021 - “...P05091 Aldehyde dehydrogenase ALDH2 4 Homo sapiens P37058 Testosterone 17-beta-dehydrogenase 3 HSD17B3 3 Homo sapiens Q13887 Krueppel-like factor 5 KLF5 2 Homo sapiens Q15788 Nuclear receptor coactivator 1 NCOA1 6 Homo sapiens Q12809 Potassium voltage-gated channel subfamily H member 2 KCNH2 5 Homo sapiens Q9H4B7 Tubulin...”
- Roles of Krüppel-like factor 5 in kidney disease.
Li, Journal of cellular and molecular medicine 2021 - “...Colon, duodenum, small intestine, stomach and kidney. (Mouse ENCODE transcriptome data) Ensembl ENSG00000102554 ENSMUSG00000005148 UniProt Q13887 Q9Z0Z7 Abbreviations: BTEB2, basic transcription elementbinding protein 2; CKLF, colon Krppellike factor; Da, Dalton; ENCODE, encyclopaedia of DNA elements; HPA, Human Protein Atlas; IKLF, intestinal enriched Krppellike factor. John Wiley...”
- Synergistic Effect of Network-Based Multicomponent Drugs: An Investigation on the Treatment of Non-Small-Cell Lung Cancer with Compound Liuju Formula.
Su, Evidence-based complementary and alternative medicine : eCAM 2019 - “...13 P37231 Peroxisome proliferator-activated receptor gamma PPARG 23 Q08828 Adenylate cyclase type 1 ADCY1 12 Q13887 Krueppel-like factor 5 KLF5 1 Q9NYA1 Sphingosine kinase 1 SPHK1 3 Q9UBM7 7-dehydrocholesterol reductase DHCR7 14 P00915 Carbonic anhydrase 1 CA1 6 P00918 Carbonic anhydrase 2 CA2 17 P04798 Cytochrome...”
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NP_608529 cabut, isoform B from Drosophila melanogaster
42% identity, 21% coverage
- A survey of well conserved families of C2H2 zinc-finger genes in Daphnia
Seetharam, BMC genomics 2010 - “...KLF1B (Dappu-51551) scaffold_26:196741-197325 KLF3 (P57682) CG3065 (NP_726393) MUA1 (AAU20846) KLF1C (Dappu-243802) scaffold_26:237754-238940 KLF4 (O43474) CABUT (NP_608529) KLF1D (Dappu-262353) scaffold_168:128271-129531 KLF5 (Q13887) LUNA (NP_995811) KLF3 (Dappu-27999) scaffold_1:1214746-1215144 KLF6 (Q99612) BTEB2 (NP_572185) LUNA (Dappu-310992) scaffold_3:2311937-2324470 KLF7 (O75840) CABUT (Dappu-312628) scaffold_6:1962325-1965508 KLF8 (O95600) KLF9 (Dappu-315814) scaffold_15:985228-986723 KLF9 (Q13886) BTEB2...”
XP_015141159 Krueppel-like factor 3 isoform X1 from Gallus gallus
43% identity, 21% coverage
XP_018084225 Kruppel-like factor 8 L homeolog isoform X1 from Xenopus laevis
45% identity, 21% coverage
KLF3_HUMAN / P57682 Krueppel-like factor 3; Basic krueppel-like factor; CACCC-box-binding protein BKLF; TEF-2 from Homo sapiens (Human) (see paper)
NP_057615 Krueppel-like factor 3 from Homo sapiens
45% identity, 21% coverage
- function: Binds to the CACCC box of erythroid cell-expressed genes. May play a role in hematopoiesis (By similarity).
subunit: Monomer. - Molecular Expression and Prognostic Implications of Krüppel-Like Factor 3 (KLF3) in Clear Cell Renal Cell Carcinoma.
Wan, Critical reviews in eukaryotic gene expression 2024 (PubMed)- GeneRIF: Molecular Expression and Prognostic Implications of Kruppel-Like Factor 3 (KLF3) in Clear Cell Renal Cell Carcinoma.
- KLF3 Transcription Activates WNT1 and Promotes the Growth and Metastasis of Gastric Cancer via Activation of the WNT/β-Catenin Signaling Pathway.
Li, Laboratory investigation; a journal of technical methods and pathology 2023 (PubMed)- GeneRIF: KLF3 Transcription Activates WNT1 and Promotes the Growth and Metastasis of Gastric Cancer via Activation of the WNT/beta-Catenin Signaling Pathway.
- microRNA-92b-3p augments colon cancer development through inhibiting KLF3.
Liu, Journal of biochemical and molecular toxicology 2023 (PubMed)- GeneRIF: microRNA-92b-3p augments colon cancer development through inhibiting KLF3.
- Pan-cancer analysis of Krüppel-like factor 3 and its carcinogenesis in pancreatic cancer.
Zhu, Frontiers in immunology 2023 - GeneRIF: Pan-cancer analysis of Kruppel-like factor 3 and its carcinogenesis in pancreatic cancer.
- Decreased KLF3 Expression via miR-660-5p Targeting Suppresses Gastric Cancer Cell Progression.
Yu, Annals of clinical and laboratory science 2023 (PubMed)- GeneRIF: Decreased KLF3 Expression via miR-660-5p Targeting Suppresses Gastric Cancer Cell Progression.
- microRNA-21-5p from M2 macrophage-derived extracellular vesicles promotes the differentiation and activity of pancreatic cancer stem cells by mediating KLF3.
Chang, Cell biology and toxicology 2022 - GeneRIF: microRNA-21-5p from M2 macrophage-derived extracellular vesicles promotes the differentiation and activity of pancreatic cancer stem cells by mediating KLF3.
- Hepatic Meteorin-like and Krüppel-like Factor 3 are Associated with Weight Loss and Liver Injury.
Grander, Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association 2022 (PubMed)- GeneRIF: Hepatic Meteorin-like and Kruppel-like Factor 3 are Associated with Weight Loss and Liver Injury.
- Exosome miR-23a-3p from Osteoblast Alleviates Spinal Cord Ischemia/Reperfusion Injury by Down-Regulating KLF3-Activated CCNL2 Transcription.
Wu, Developmental neuroscience 2022 (PubMed)- GeneRIF: Exosome miR-23a-3p from Osteoblast Alleviates Spinal Cord Ischemia/Reperfusion Injury by Down-Regulating KLF3-Activated CCNL2 Transcription.
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- Unravelling Structure, Localization, and Genetic Crosstalk of KLF3 in Human Breast Cancer
Khan, BioMed research international 2020 - “...shown that KLF3 is located in the nucleus which was confirmed through UniProtKB (entry no. P57682). Evolutionary conservation was confirmed by the presence of conserved domains: three zinc fingers among members of KLFs, and it was also relatable to literature [ 18 ] and the UniProtKB...”
- Expression, Localization of SUMO-1, and Analyses of Potential SUMOylated Proteins in Bubalus bubalis Spermatozoa
Brohi, Frontiers in physiology 2017 - “...alpha-induced protein 2 3 SC K663 Extended PDSM Saccharomyces cerevisiae [(P38904)]-Homo sapiens [(Q75MX6), (Q9UGLI), KLF3 (P57682), KLF8 (095600), SAFB2 (Q14151)]-Vaccinia virus [A40R(P21063)] G1 Tubulin alpha-1D chain-like 1 SC K304 SUMO-Ac switch Cytoplasm A,Z G2 Tubulin alpha-1C chain-like 1 SC K230 SUMO-Ac switch Cytoplasm A,Z G3 Tubulin...”
- SP and KLF Transcription Factors in Digestive Physiology and Diseases.
Kim, Gastroenterology 2017 - “...SP5 (Q6BEB4), SP6 (Q3SY56), SP7 (Q87DD2), SP8 (Q8IXZ3), SP9 (P0CG40), KLF1 (Q13351), KLF2 (Q9Y5W3), KLF3 (P57682), KLF4 (Q43474), KLF5 (Q13887), KLF6 (Q99612), KLF7 (O75840), KLF8 (O95600), KLF9 (Q13886), KLF10 (Q13118), KLF11 (O14901), KLF12 (Q9Y4X4), KLF13 (Q9Y2Y9), KLF14 (Q8TD49), KLF15 (Q9UIH9), KLF16 (Q9BXK1), and KLF17 (Q5JT82). Figure...”
- Krüppel-like factors in cancer progression: three fingers on the steering wheel.
Limame, Oncotarget 2014 - “...E-KLF JX877554 Q13351 362 38.2 KLF2 L-KLF EF078888 Q9Y5W3 355 37.4 KLF3 B-KLF, TEF-2 NM_016531 P57682 345 38.8 KLF4 G-KLF, EZF DQ658241 O43474 513 54 KLF5 I-KLF, C-KLF, BTEB2 AF287272 Q13887 457 50.8 KLF6 BCD1, COBEP, CBPB, ST12, GBF AF284036 Q99612 283 31.9 KLF7 U-KLF O75840...”
- A survey of well conserved families of C2H2 zinc-finger genes in Daphnia
Seetharam, BMC genomics 2010 - “...KLF1 (NP_497632) KLF1A (Dappu-48391) scaffold_16:1551074-1551469 KLF2 (Q9Y5W3) CG9895 (NP_611747) F53F8.1 (NP_507995) KLF1B (Dappu-51551) scaffold_26:196741-197325 KLF3 (P57682) CG3065 (NP_726393) MUA1 (AAU20846) KLF1C (Dappu-243802) scaffold_26:237754-238940 KLF4 (O43474) CABUT (NP_608529) KLF1D (Dappu-262353) scaffold_168:128271-129531 KLF5 (Q13887) LUNA (NP_995811) KLF3 (Dappu-27999) scaffold_1:1214746-1215144 KLF6 (Q99612) BTEB2 (NP_572185) LUNA (Dappu-310992) scaffold_3:2311937-2324470 KLF7 (O75840)...”
NP_001073472 Krueppel-like factor 8 from Danio rerio
44% identity, 21% coverage
NP_001273747 Krueppel-like factor 5 isoform 2 from Homo sapiens
46% identity, 20% coverage
NCU02666 NSDC from Neurospora crassa OR74A
48% identity, 10% coverage
- Cold Shock as a Screen for Genes Involved in Cold Acclimatization in Neurospora crassa
Watters, G3 (Bethesda, Md.) 2018 - “...Process NCU02639 16474 Argininosuccinate synthase arg-1 E. coli CS Orth Catalytic Activity Cellular Process/Metabolic Process NCU02666 11344 zinc finger transcription factor-58 znf-58 Transc Factors NCU02671 11345 cutinase G-box binding protein msn-1 Transc Factors NCU02699 11347 zinc finger transcription factor-14 znf-14 Transc Factors NCU02712 15714 acetate-10 ace-10...”
KLF12_HUMAN / Q9Y4X4 Krueppel-like factor 12; Transcriptional repressor AP-2rep from Homo sapiens (Human) (see paper)
NP_009180 Krueppel-like factor 12 isoform 1 from Homo sapiens
47% identity, 18% coverage
- function: Confers strong transcriptional repression to the AP-2-alpha gene. Binds to a regulatory element (A32) in the AP-2-alpha gene promoter
- The role of HR-HPV integration in the progression of premalignant lesions into different cancer types.
Catalán-Castorena, Heliyon 2024 - “...analysis E1, E2 and E5 Introns, exons, and intergenic regions MYC (P01106) KLF5 (Q13887) KLF12 (Q9Y4X4) HIF1A (Q16665) CASZ1 (Q86V15) GPN(Q9HCN4) MBD5 (Q9P267) ORC2 (Q13416) PARD3B (Q8TEW8) ERBB4 (Q15303) FHIT (P49789) MECOM (Q03112) ATP11B (Q9Y2G3) CLDN1 (O95832) IL8 (P10145) DUX4L2 (P0CJ85) SLC29A1 (Q99808) RUNX2 (Q13950) CREB5...”
- “...L2 and LCR Introns, exons, flanking regions of genes POU5F1B (Q06416) FHIT ( P49789) KLF12 (Q9Y4X4) KLF5 (Q13887) LRP1B (Q9NZR2) LEPREL1 (Q8IVL5) HMGA2 (P52926) DLG2 (Q15700) SEMA3D (O95025) MYC (P01106) [ 156 ] 72 cervical cancer biopsies with HR-HPV (16, 18, 33, 45, 51, 45, 68)...”
- SP and KLF Transcription Factors in Digestive Physiology and Diseases.
Kim, Gastroenterology 2017 - “...KLF5 (Q13887), KLF6 (Q99612), KLF7 (O75840), KLF8 (O95600), KLF9 (Q13886), KLF10 (Q13118), KLF11 (O14901), KLF12 (Q9Y4X4), KLF13 (Q9Y2Y9), KLF14 (Q8TD49), KLF15 (Q9UIH9), KLF16 (Q9BXK1), and KLF17 (Q5JT82). Figure 2 Post-translational Modifications and Co-factors That Interact With SP and KLF Proteins SP/KLF protein is illustrated as a...”
- Krüppel-like factors in cancer progression: three fingers on the steering wheel.
Limame, Oncotarget 2014 - “...EGR NM_005655 Q13118 480 52.6 KLF11 F-KLF, TIEG2, MODY7 O14901 512 55.1 KLF12 AP2rep, HSPC122 Q9Y4X4 402 44.2 KLF13 BTEB3, NSLP1, RFLAT-1 NM_015995 Q9Y2Y9 288 31.2 KLF14 BTEB5, SP6, EPFN DQ534757 Q8TD94 323 33.1 KLF15 K-KLF NM_014079 Q9UIH9 416 44 KLF16 BTEB4, NSLP2, DRRF NM_031918 Q9BXK1...”
- KLF12 promotes the proliferation of breast cancer cells by reducing the transcription of p21 in a p53-dependent and p53-independent manner.
Li, Cell death & disease 2023 - GeneRIF: KLF12 promotes the proliferation of breast cancer cells by reducing the transcription of p21 in a p53-dependent and p53-independent manner.
- MiR-17-5p promoter methylation regulated by DNA methyltransferase 3 beta (DNMT3B) expedites endometriosis via the Krüppel-like factor 12 (KLF12)/Wnt/β-catenin axis.
Yang, Journal of reproductive immunology 2023 (PubMed)- GeneRIF: MiR-17-5p promoter methylation regulated by DNA methyltransferase 3 beta (DNMT3B) expedites endometriosis via the Kruppel-like factor 12 (KLF12)/Wnt/beta-catenin axis.
- Krüppel-like factor 12 regulates aging ovarian granulosa cell apoptosis by repressing SPHK1 transcription and sphingosine-1-phosphate (S1P) production.
Zhang, The Journal of biological chemistry 2023 - GeneRIF: Kruppel-like factor 12 regulates aging ovarian granulosa cell apoptosis by repressing SPHK1 transcription and sphingosine-1-phosphate (S1P) production.
- KLF12 transcriptionally regulates PD-L1 expression in non-small cell lung cancer.
Pan, Molecular oncology 2023 - GeneRIF: KLF12 transcriptionally regulates PD-L1 expression in non-small cell lung cancer.
- Circ_0084188 promotes colorectal cancer progression by sponging miR-654-3p and regulating kruppel-like factor 12.
Wu, The Kaohsiung journal of medical sciences 2023 (PubMed)- GeneRIF: Circ_0084188 promotes colorectal cancer progression by sponging miR-654-3p and regulating kruppel-like factor 12.
- MicroRNA-650 suppresses KLF12 expression to regulate growth and metastasis of human ovarian cancer cells.
Lu, Acta biochimica Polonica 2022 (PubMed)- GeneRIF: MicroRNA-650 suppresses KLF12 expression to regulate growth and metastasis of human ovarian cancer cells.
- Krüppel-like factor 12 suppresses bladder cancer growth through transcriptionally inhibition of enolase 2.
Tang, Gene 2021 (PubMed)- GeneRIF: Kruppel-like factor 12 suppresses bladder cancer growth through transcriptionally inhibition of enolase 2.
- Knockdown of circ_0075503 suppresses cell migration and invasion by regulating miR-15a-5p and KLF12 in endometriosis.
Liu, Molecular and cellular biochemistry 2021 (PubMed)- GeneRIF: Knockdown of circ_0075503 suppresses cell migration and invasion by regulating miR-15a-5p and KLF12 in endometriosis.
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ACE2 potential zinc finger transcription factor from Candida albicans (see 4 papers)
46% identity, 9% coverage
- CharProtDB CGD description: Putative transcription factor involved in regulation of morphogenesis; required for wild-type cell separation, adherence, biofilm formation, and virulence in mouse; mutant is hyperfilamentous; similar to S. cerevisiae Ace2p and Swi5p
ACE2_YEAST / P21192 Metallothionein expression activator from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see paper)
YLR131C Ace2p from Saccharomyces cerevisiae
NP_013232 DNA-binding transcription factor ACE2 from Saccharomyces cerevisiae S288C
47% identity, 9% coverage
- function: Plays a role in regulating basal-level expression of CUP1. Activates EGT2 transcription in the absence of SWI5
- Isolation and characterization of Saccharomyces cerevisiae mutants with increased cell wall chitin using fluorescence-activated cell sorting
Chuene, FEMS yeast research 2024 - “...the vacuolar transporter chaperone (VTC) complex involved in membrane trafficking (Cohen et al. 1999 ). YLR131C * 1 (1G) ACE2 Sequence-specific DNA binding Transcription factor required for septum destruction after cytokinesis; Ace2 transcriptional activator of CTS1 gene (endochitinase) (Butler and Thiele 1991 ). YLR425W * 3...”
- Metabolic regulation of misfolded protein import into mitochondria
Wang, eLife 2024 - “...DIA4 Class 2 YHR143W DSE2 Class 2 YCL005W LDB16 Class 2 YCL037C SRO9 Class 2 YLR131C ACE2 Class 2 YMR074C SDD2 Class 2 YKL009W MRT4 Class 2 YKL128C PMU1 Class 2 YKL132C RMA1 Class 2 YGR056W RSC1 Class 2 YOR125C CAT5 Class 2 YAL043C-a Class 2...”
- Investigation of Genome Biology by Synthetic Genome Engineering
Zhang, Bioengineering (Basel, Switzerland) 2023 - “...YBR220C result in hygromycin B resistance [ 83 ], and a deletion of the gene YLR131C results in ethanol tolerance [ 82 ]. Moreover, SCRaMbLE also serves as a tool to improve host strain or increase yield, and provides a platform for studying metabolic pathways [...”
- Forward and reverse genetic dissection of morphogenesis identifies filament-competent Candida auris strains
Santana, Nature communications 2021 - “...by vortexing (Fig. 2 ). Insertion events in CauACE2 (B9J08_000468), orthologous to S. cerevisiae ACE2 (YLR131C), as well as in CauTAO3 (B9J08_000181), orthologous to S. cerevisiae TAO3 (YIL129C), were associated with this aggregatory phenotype. A similar aggregating phenotype resulted from an insertion near the C-terminus of...”
- Dynamic network inference and association computation discover gene modules regulating virulence, mycotoxin and sexual reproduction in Fusarium graminearum
Guo, BMC genomics 2020 - “...M39; this module is enriched in TFBS ( Ace2p ), which is likely bound by YLR131C in Sc . Interestingly, one of the predicted regulators of module FGSG_01341 is orthologous to YLR131C (E-value=3.34e-17). The YEASTRACT database showed that this conserved TFBS and TF are involved in...”
- Aligning functional network constraint to evolutionary outcomes
Wollenberg, BMC evolutionary biology 2020 - “...[ 49 ] I SIR1 YKR101W Gresham et al. 2008 [ 51 ] I ACE2 YLR131C Lang et al., 2013 [ 49 ] I GAS1 YMR307W Lang et al., 2013 [ 49 ] I WHI2 YOR043W Lang et al., 2013 [ 49 ] I CKA2 YOR061W...”
- Nucleosome Dynamics: a new tool for the dynamic analysis of nucleosome positioning
Buitrago, Nucleic acids research 2019 - “...2. Visualization of Nucleosome Dynamics results in MuGVRE. ( A ) Nucleosome positioning along ACE2 (YLR131C) gene from S. cerevisiae between G2 and M cell cycle phases (a) YLR131C open reading frame; (b) ACE2 full length transcripts; (c), (c') coverage of MNase-seq reads aligned to reference...”
- NoLogo: a new statistical model highlights the diversity and suggests new classes of Crm1-dependent nuclear export signals
Liku, BMC bioinformatics 2018 - “...the performance of NoLogo (YPL015C, YDR499W, YEL032W, YER125W, YAL047C, YML007W, YKL143W, YKR048C, YHR170W, YMR235C, YMR232W, YLR131C, YOL111C, YIR006C, YOR329C; See Additionalfile 1 : Table S1 or Additionalfile 2 : Figure S1). The remaining NESs were included in the 19ScNESs test set (These consisted of YBL105C, YDL207W,...”
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- Asymmetric Transcription Factor Partitioning During Yeast Cell Division Requires the FACT Chromatin Remodeler and Cell Cycle Progression.
Herrero, Genetics 2020 - GeneRIF: Asymmetric Transcription Factor Partitioning During Yeast Cell Division Requires the FACT Chromatin Remodeler and Cell Cycle Progression.
- Identifying and characterizing SCRaMbLEd synthetic yeast using ReSCuES.
Luo, Nature communications 2018 - GeneRIF: ACE2, a transcription factor required for septum destruction after cytokinesis, is a negative regulator of ethanol tolerance.
- The transcription factor Ace2 and its paralog Swi5 regulate ethanol production during static fermentation through their targets Cts1 and Rps4a in Saccharomyces cerevisiae.
Wu, FEMS yeast research 2016 (PubMed)- GeneRIF: Therefore, Ace2 and Swi5 are two negative regulators of ethanol yield during static fermentation of yeast cells, and both CTS1 and RPS4a are major effectors mediating these two transcription factors in regulating ethanol production.
- The Rts1 regulatory subunit of PP2A phosphatase controls expression of the HO endonuclease via localization of the Ace2 transcription factor.
Parnell, The Journal of biological chemistry 2014 - GeneRIF: Data show that mutation of the Rts1 regulatory subunit of PP2A phosphatase (PP2ARts1 phosphatase) results in decreased HO endonuclease expression due to altered localization of the Ace2 transcription factor.
- Genome duplication and mutations in ACE2 cause multicellular, fast-sedimenting phenotypes in evolved Saccharomyces cerevisiae.
Oud, Proceedings of the National Academy of Sciences of the United States of America 2013 - GeneRIF: Genome duplication and mutations in ACE2 cause multicellular, fast-sedimenting phenotypes in evolved Saccharomyces cerevisiae.
- Nuclear envelope morphology constrains diffusion and promotes asymmetric protein segregation in closed mitosis.
Boettcher, The Journal of cell biology 2012 - GeneRIF: show that Ace2 asymmetry is initiated in the elongated, but undivided, anaphase nucleus
- New insight into the role of the Cdc34 ubiquitin-conjugating enzyme in cell cycle regulation via Ace2 and Sic1.
Cocklin, Genetics 2011 - GeneRIF: we discovered previously unrecognized levels of regulation of the Ace2 transcription factor and the cyclin-dependent protein kinase inhibitor Sic1
- Sequential counteracting kinases restrict an asymmetric gene expression program to early G1.
Mazanka, Molecular biology of the cell 2010 - GeneRIF: Data show that Ace2's nuclear localization is maintained by continuous Cbk1 activity and that inhibition of the kinase leads to immediate loss of phosphorylation and export to the cytoplasm.
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ACE2_CANAL / Q59RR0 Cell wall transcription factor ACE2 from Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast) (see 7 papers)
XP_712331 DNA-binding transcription factor from Candida albicans SC5314
46% identity, 9% coverage
- function: Transcription factor involved in the RAM (regulation of ACE2 transcription factor and polarized morphogenesis) signaling network that regulates polarized morphogenesis. Regulates expression of genes involved in cell separation such as CHT3, DSE1, and SCW11; or other cell wall genes such as ASH1, DSE4, PIR1, PRY2, and RME1. Required for regulation of morphogenesis, cell separation, adherence, biofilm formation, invasion, as well as virulence in a mouse model of infection.
- Prediction of multi-drug resistance transporters using a novel sequence analysis method.
McDermott, F1000Research 2015 - “...of the individual PILGram models matches the single (Q24174, beginning at residue 540) or double (Q59RR0, beginning at residue 645) zinc finger motifs completely, but that the overlap score for the functional regions in both sequences are higher than surrounding sequences. Alignments for the complete set...”
- “...Q24174 PILGram 9 ATDPRPCPK CGK IYRSAHTLRTHLEDKHTVCPGY Q24174 PILGram 10 ATDPRPCPKCGKIYRSAHTLRTHLEDKHTVCPGY Q24174 Summary 222222 3334332222223344444455 444333 Q59RR0 PS00028 EDKIYT CTYKNCGKKFTRRYNVRSHIQTH LSDRPFG CQFCPKRFVRQHDLNRHVKGH IEARYS Q59RR0 PILGram 1 EDKIYTCTYKNCGKKFTRRYNV RSHIQTHLSDRPFGCQFC PKRFVRQHDLNRHVKGHIEARYS Q59RR0 PILGram 2 EDKIYTCTYKNCGKKFTRRYNVRSHIQTHLSDRPFGCQFCPKRFVRQHDLNRHVKGHIEARYS Q59RR0 PILGram 3 EDKIYTCTYKNCGKKFTRRYN VRSHIQTHLSDRPFGCQFC PKRFVRQHDLNRHVKGHIEARYS Q59RR0 PILGram 4 EDKIYTCTYKNCGKK FTRRYNVRSHIQTHLSDRPFGCQFCPKRFVRQHDLNRHVKGHIEARYS Q59RR0 PILGram 5...”
- The Cbk1-Ace2 axis guides Candida albicans from yeast to hyphae and back again.
Wakade, Current genetics 2021 - GeneRIF: The Cbk1-Ace2 axis guides Candida albicans from yeast to hyphae and back again.
- The Ndr/LATS Kinase Cbk1 Regulates a Specific Subset of Ace2 Functions and Suppresses the Hypha-to-Yeast Transition in Candida albicans.
Wakade, mBio 2020 - GeneRIF: The Ndr/LATS Kinase Cbk1 Regulates a Specific Subset of Ace2 Functions and Suppresses the Hypha-to-Yeast Transition in Candida albicans.
- Complex Haploinsufficiency-Based Genetic Analysis of the NDR/Lats Kinase Cbk1 Provides Insight into Its Multiple Functions in Candida albicans.
Saputo, Genetics 2016 - GeneRIF: In addition to a large set of genes regulated by the RAM transcription factor Ace2, genes related to cell wall biosynthesis, cell cycle, polarity, oxidative stress, and nitrogen utilization were identified
- Efg1 directly regulates ACE2 expression to mediate cross talk between the cAMP/PKA and RAM pathways during Candida albicans morphogenesis.
Saputo, Eukaryotic cell 2014 - GeneRIF: Under embedded conditions, Efg1 is dispensable for filamentation and Ace2 is required. We have found that ACE2 expression is much higher in embedded cells than in planktonic cells, providing a potential rationale for this observation.
- Damage to the glycoshield activates PMT-directed O-mannosylation via the Msb2-Cek1 pathway in Candida albicans.
Cantero, Molecular microbiology 2011 (PubMed)- GeneRIF: The authors propose that a Msb2, Cek1 and Ace2 signalling pathway addresses PMT genes as downstream targets and that different modes of regulation have evolved for PMT1 and PMT2/PMT4 genes.
- A large-scale complex haploinsufficiency-based genetic interaction screen in Candida albicans: analysis of the RAM network during morphogenesis.
Bharucha, PLoS genetics 2011 - GeneRIF: cAMP-dependent protein kinase A -regulated transcription factor Efg1 and Ace2 regulate a common set of genes at separate stages of morphogenesis.
Q9Z0Z7 Krueppel-like factor 5 from Mus musculus
NP_033899 Krueppel-like factor 5 from Mus musculus
44% identity, 16% coverage
- Roles of Krüppel-like factor 5 in kidney disease.
Li, Journal of cellular and molecular medicine 2021 - “...duodenum, small intestine, stomach and kidney. (Mouse ENCODE transcriptome data) Ensembl ENSG00000102554 ENSMUSG00000005148 UniProt Q13887 Q9Z0Z7 Abbreviations: BTEB2, basic transcription elementbinding protein 2; CKLF, colon Krppellike factor; Da, Dalton; ENCODE, encyclopaedia of DNA elements; HPA, Human Protein Atlas; IKLF, intestinal enriched Krppellike factor. John Wiley &...”
- KLF5-mediated pyroptosis of airway epithelial cells leads to airway inflammation in asthmatic mice through the miR-182-5p/TLR4 axis.
Lin, Molecular immunology 2024 (PubMed)- GeneRIF: KLF5-mediated pyroptosis of airway epithelial cells leads to airway inflammation in asthmatic mice through the miR-182-5p/TLR4 axis.
- Interruption of KLF5 acetylation promotes PTEN-deficient prostate cancer progression by reprogramming cancer-associated fibroblasts.
Zhang, The Journal of clinical investigation 2024 - GeneRIF: Interruption of KLF5 acetylation promotes PTEN-deficient prostate cancer progression by reprogramming cancer-associated fibroblasts.
- HDAC6 promotes inflammation in lupus nephritis mice by regulating transcription factors MAFF and KLF5 in renal fibrosis.
Deng, Renal failure 2024 - GeneRIF: HDAC6 promotes inflammation in lupus nephritis mice by regulating transcription factors MAFF and KLF5 in renal fibrosis.
- MicroRNA-375 repression of Kruppel-like factor 5 improves angiogenesis in diabetic critical limb ischemia.
McCoy, Angiogenesis 2023 (PubMed)- GeneRIF: MicroRNA-375 repression of Kruppel-like factor 5 improves angiogenesis in diabetic critical limb ischemia.
- Knockdown of KLF5 ameliorates renal fibrosis in MRL/lpr mice via inhibition of MX1 transcription.
Tao, Immunity, inflammation and disease 2023 - GeneRIF: Knockdown of KLF5 ameliorates renal fibrosis in MRL/lpr mice via inhibition of MX1 transcription.
- KLF5 protects the intestinal epithelium against Th17 immune response in a murine colitis model.
Shieh, JCI insight 2022 - GeneRIF: KLF5 protects the intestinal epithelium against Th17 immune response in a murine colitis model.
- A WWP2-PTEN-KLF5 signaling axis regulates odontoblast differentiation and dentinogenesis in mice.
Fu, The Journal of biological chemistry 2022 - GeneRIF: A WWP2-PTEN-KLF5 signaling axis regulates odontoblast differentiation and dentinogenesis in mice.
- Krüppel-like factor 5 accelerates the pathogenesis of Alzheimer's disease via BACE1-mediated APP processing.
Wang, Alzheimer's research & therapy 2022 - GeneRIF: Kruppel-like factor 5 accelerates the pathogenesis of Alzheimer's disease via BACE1-mediated APP processing.
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XP_059743521 Krueppel-like factor 3 isoform X1 from Bos taurus
45% identity, 21% coverage
TRIATDRAFT_234627 uncharacterized protein from Trichoderma atroviride
47% identity, 12% coverage
KLF1_CAEEL / Q9TZ64 Kruppel-like factor 1 from Caenorhabditis elegans (see 3 papers)
NP_497632 Kruppel-like factor 1 from Caenorhabditis elegans
47% identity, 14% coverage
- function: Transcription factor which modulates genes involved in lipid metabolism and the phase I detoxification pathway, including cytochrome P450 oxidases (PubMed:18680432, PubMed:24805825, PubMed:31346165). Required for diet restriction- and mitochondrial dysfunction-mediated lifespan extension, perhaps acting in a ubiquitination-dependent manner (PubMed:24805825, PubMed:31346165). Involved in the response to oxidative stress (PubMed:31346165). Plays a role in cell death (PubMed:18680432).
subunit: Interacts with E3 ubiquitin-protein ligase wwp-1 (via WW domains).
disruption phenotype: RNAi-mediated knockown leads to increased cell death, perhaps by apoptosis, in the germline and uterus of hermaphrodites (PubMed:18680432). Lipid contents in the intestine increase (PubMed:18680432). RNAi-mediated knockdown causes reduced ability of dietary restriction to extend lifespan (PubMed:24805825). Abolishes lifespan extension completely on an eat-2 mutant background, independent of whether knockdown is ubiquitous, or targeted only to the intestine (PubMed:24805825). Abolishes lifespan extension on either isp-1;ctb-1 double mutant, or isp-1, gas-1 or mev-1 single mutant backgrounds; knockdown is most effective when applied in early adulthood, rather than during early development (PubMed:31346165). Further decreases the lower movement rates of isp-1;ctb-1 double mutants (PubMed:31346165). - KLF-1 orchestrates a xenobiotic detoxification program essential for longevity of mitochondrial mutants.
Herholz, Nature communications 2019 - GeneRIF: KLF-1 is a mediator of a cytoprotective response that dictates longevity induced by reduced mitochondrial function.
- A conserved KLF-autophagy pathway modulates nematode lifespan and mammalian age-associated vascular dysfunction.
Hsieh, Nature communications 2017 - GeneRIF: overexpression modestly extended lifespan
- Bioinformatic analysis of the four transcription factors used to induce pluripotent stem cells
Ma, Cytotechnology 2014 - “...NP_001106531 NP_001009178 NP_002692 Sox2 NP_741836 / NP_998283 NP_990519 XP_516895 NP_001098933 NP_035573 NP_001116669 NP_001102651 NP_003097 Klf4 NP_497632 / NP_001106955 XP_418264 XP_001141754 NP_001098855 NP_034767 NP_001106531 NP_446165 NP_004226 Nanog / / NP_001091862 NP_001139614 NP_001065295 NP_001020515 NP_082292 NP_001123443 NP_001094251 NP_079141 All the protein ids were derived from NCBI database and...”
- A Krüppel-like factor downstream of the E3 ligase WWP-1 mediates dietary-restriction-induced longevity in Caenorhabditis elegans.
Carrano, Nature communications 2014 - GeneRIF: WWP-1 directly interacts with KLF-1 and mediates multiple monoubiquitylation of KLF-1 in vitro and in cellulo. The data support a model in which modulation of KLF-1 by WWP-1 regulates diet-restriction-induced longevity.
- A survey of well conserved families of C2H2 zinc-finger genes in Daphnia
Seetharam, BMC genomics 2010 - “...(Q02446) SP5 (Q6BEB4) SP6/KLF14 (Q3SY56) SP7 (Q8TDD2) SP8 (Q8IXZ3) KLF KLF1 (Q13351) CG12029 (NP_647822) KLF1 (NP_497632) KLF1A (Dappu-48391) scaffold_16:1551074-1551469 KLF2 (Q9Y5W3) CG9895 (NP_611747) F53F8.1 (NP_507995) KLF1B (Dappu-51551) scaffold_26:196741-197325 KLF3 (P57682) CG3065 (NP_726393) MUA1 (AAU20846) KLF1C (Dappu-243802) scaffold_26:237754-238940 KLF4 (O43474) CABUT (NP_608529) KLF1D (Dappu-262353) scaffold_168:128271-129531 KLF5 (Q13887)...”
NP_001106955 Krueppel-like factor 4 from Danio rerio
A9X6Q5 Krueppel-like factor 4 from Danio rerio
46% identity, 18% coverage
KLFL_DROME / Q8MR37 Krueppel-like factor luna from Drosophila melanogaster (Fruit fly) (see 2 papers)
NP_001260879 luna, isoform C from Drosophila melanogaster
NP_995811 luna, isoform B from Drosophila melanogaster
46% identity, 13% coverage
- function: Probable transcription factor that is required for cell differentiation (PubMed:14527717, PubMed:24915236). Essential for proper separation of the sister chromatids during early nuclear division cycles in the syncytial pre-blastoderm embryo (PubMed:24915236).
disruption phenotype: RNAi-mediated knockdown in embryos is semi- lethal, with half of the mutants dying prior to gastrulation and display numerous vacuoles. Escaper embryos die at the third instar larval or early pupal stages, displaying black necrotic plaques. - Luna, a Drosophila KLF6/KLF7, is maternally required for synchronized nuclear and centrosome cycles in the preblastoderm embryo.
Weber, PloS one 2014 - GeneRIF: luna mutants are associated with very early embryonic defects prior to cellularization at the syncytial stage and cause DNA separation defects.
- A survey of well conserved families of C2H2 zinc-finger genes in Daphnia
Seetharam, BMC genomics 2010 - “...MUA1 (AAU20846) KLF1C (Dappu-243802) scaffold_26:237754-238940 KLF4 (O43474) CABUT (NP_608529) KLF1D (Dappu-262353) scaffold_168:128271-129531 KLF5 (Q13887) LUNA (NP_995811) KLF3 (Dappu-27999) scaffold_1:1214746-1215144 KLF6 (Q99612) BTEB2 (NP_572185) LUNA (Dappu-310992) scaffold_3:2311937-2324470 KLF7 (O75840) CABUT (Dappu-312628) scaffold_6:1962325-1965508 KLF8 (O95600) KLF9 (Dappu-315814) scaffold_15:985228-986723 KLF9 (Q13886) BTEB2 (Dappu-50068) scaffold_21:551156-551927 KLF10 (Q13118) KLF1E (Dappu-262162) scaffold_164:255538-257421...”
SWI5_YEAST / P08153 Transcriptional factor SWI5 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see 2 papers)
NP_010430 DNA-binding transcription factor SWI5 from Saccharomyces cerevisiae S288C
YDR146C Swi5p from Saccharomyces cerevisiae
47% identity, 10% coverage
- function: Determines the mother-cell-specific transcription of the HO endonuclease gene that is responsible for the initiation of mating-type switching in yeast. Recognizes a specific sequence in the promoter of the HO gene. Activates EGT2 transcription in a concentration-dependent manner. Synthesized during G2 and early mitosis
- Forkhead transcription factor Fkh1: insights into functional regulatory domains crucial for recruitment of Sin3 histone deacetylase complex.
Aref, Current genetics 2021 - GeneRIF: Forkhead transcription factor Fkh1: insights into functional regulatory domains crucial for recruitment of Sin3 histone deacetylase complex.
- Two auxiliary factors promote Dmc1-driven DNA strand exchange via stepwise mechanisms.
Tsubouchi, Proceedings of the National Academy of Sciences of the United States of America 2020 - GeneRIF: Two auxiliary factors promote Dmc1-driven DNA strand exchange via stepwise mechanisms.
- The transcription factor Ace2 and its paralog Swi5 regulate ethanol production during static fermentation through their targets Cts1 and Rps4a in Saccharomyces cerevisiae.
Wu, FEMS yeast research 2016 (PubMed)- GeneRIF: Therefore, Ace2 and Swi5 are two negative regulators of ethanol yield during static fermentation of yeast cells, and both CTS1 and RPS4a are major effectors mediating these two transcription factors in regulating ethanol production.
- A refined two-hybrid system reveals that SCF(Cdc4)-dependent degradation of Swi5 contributes to the regulatory mechanism of S-phase entry.
Kishi, Proceedings of the National Academy of Sciences of the United States of America 2008 - GeneRIF: Swi5 is indeed ubiquitinated and degraded through the SCF(Cdc4) complex
- Evidence for a minimal eukaryotic phosphoproteome?
Diks, PloS one 2007 - “...Caldesmon aves highly similar EFPLSPPKK S-37 CDK P16949 stathmin mammal, insect similar VIKRSPRKR S-646 CDK P08153 transcriptional factor SWI5 yeast, mammal divergent NWHMTPPRK T-316 CDK P13681 serine/threonine protein phosphatase PP1 bacterial, yeast divergent KISITSRKA T-36 ERA P06616 GTP-binding protein era insect - DSTYYKASK Y-577 FAK P34152...”
- “...transcription from RNA polymerase II promoter protein binding, thyroid hormone receptor activity, transcription factor activity P08153 Transcriptional Factor SWI5 G1-specific transcription in mitotic cell cycle transcriptional activator activity P08057 Troponin I negative regulation of angiogenesis, regulation of heart contraction, regulation of muscle contraction actin binding, calcium...”
- Cell cycle-specified fluctuation of nucleosome occupancy at gene promoters
Hogan, PLoS genetics 2006 - “...SET4 (P42948), SET5 (P38890), SET6 (Q12529), SIC1 (P38634), STE12 (P13574), SWE1 (P32944), SWI4 (P23302), SWI5 (P08153), SWI6 (P09959), YDR222W (Q04925), YKR011C (Q02209), YPL056C (Q02786), YPR003C (P53394), and YPR022C (Q12139). We thank Laura Schenkman for technical assistance, Julian Haase and Kerry Bloom for assistance with microscopy, and...”
- mof, a putative acetyl transferase gene related to the Tip60 and MOZ human genes and to the SAS genes of yeast, is required for dosage compensation in Drosophila
Hilfiker, The EMBO journal 1997 - “...and ScSWI5 (S.cerevisiae switch 5 gene product, accession No. P08153). The distance between the C and H marked by asterisks is constant in all of the examples...”
- Comparative genomic analysis of clinical <i>Candida glabrata</i> isolates identifies multiple polymorphic loci that can improve existing multilocus sequence typing strategy
Arastehfar, Studies in mycology 2021 - “...D02871/ CAGL0D02926g BRE2 YLR015W D05049/ CAGL0D05082g UBI4 YLL039C E00341/ CAGL0E00561g TUP1 YCR084C SWI5/ CAGL0E01331g SWI5 YDR146C STP8/ CAGL0F01837g SPT8 YLR055C SLG1 1 SLG1 YOR008C HKR1/ CGAL0F03003g 1 HKR1 YDR420W F03333/ CAGL0F03641g YML018C YML018C 1 These were the 13 polymorphic loci that were selected for MLST analysis...”
- Commonalities and Differences in the Transcriptional Response of the Model Fungus Saccharomyces cerevisiae to Different Commercial Graphene Oxide Materials
Laguna-Teno, Frontiers in microbiology 2020 - “...DNA replication is challenged. For instance, several genes controlled by the CLB2 cluster (e.g., YGR108W, YDR146C, YGL116W, YIL158W, YNL058C, etc.) were downregulated, a process that has been associated as well to DNA replication stress induced by genotoxic conditions ( Palou et al., 2015 ). Interestingly, genes...”
- Transcriptional Comparison Investigating the Influence of the Addition of Unsaturated Fatty Acids on Aroma Compounds During Alcoholic Fermentation
Yan, Frontiers in microbiology 2019 - “...inheritance rate of mitochondria 3.02 YGR108W CLB1 B-type cyclin involved in cell cycle progression 2.29 YDR146C SWI5 Transcription factor that recruits the mediator and Swi/Snf complexes 2.22 YPR119W CLB2 B-type cyclin involved in cell cycle progression 2.02 YGL029W CGR1 Protein involved in nucleolar integrity and processing...”
- A large-scale analysis of autophagy-related gene expression identifies new regulators of autophagy
Bernard, Autophagy 2015 - “...GCN4 YEL009C GLN3 GAT1 YER040W YFL021W SWI5 YDR146C Increased expression in growing conditions Decreased induction upon glucose starvation Decreased induction...”
- Investigating the effects of imputation methods for modelling gene networks using a dynamic bayesian network from gene expression data
Chai, The Malaysian journal of medical sciences : MJMS 2014 (secret) - Hierarchical Dirichlet process model for gene expression clustering
Wang, EURASIP journal on bioinformatics & systems biology 2013 - “...YDL006w YDL134c YIL007c YJL187c YDL029w YDL035c YCR002c YBL105c YCR089w YER114c YEL023c Transcription YAL021c YBL022c YCL051w YDR146c YIL084c YJL127c YJL164c YJL006c 5 Conclusions In this article, we have proposed a new clustering approach based on the HDP. The HDP clustering explicitly models the hierarchical structure in the...”
- An integrated framework to model cellular phenotype as a component of biochemical networks
Gormley, Advances in bioinformatics 2011 - “...YDL056W 0.7485 CDC6 YJL194W 0.8485 CLB1 YGR108W 0.9322 CLB2 YPR119W 0.9316 CDH1 YGL003C 0.7956 SWI5 YDR146C 0.9262 MCM1 YMR043W 0.7745 Phenotype NA 0.7264 Table 3 In silico gene knock-down models predict the viability of experimental deletion of yeast cell cycle genes. Outcome of gene deletion experiments...”
- “...Inviable Viable CLB1 YGR108W Viable Viable CLB2 YPR119W Viable Viable CDH1 YGL003C Viable Inviable SWI5 YDR146C Viable Inviable MCM1 YMR043W Inviable Inviable...”
- Using GeneReg to construct time delay gene regulatory networks
Huang, BMC research notes 2010 - “...Squared YEASTRACT STRING Orlando et al. [ 14 ] SWI5_YDR146C_1770349_at ASH1_YKL185W_1772030_at 0.594772 29.40695 0.998474 SWI5->YKL185W YDR146C <->YKL185W SWI5->ASH1 YHP1_YDR451C_1778368_at SWI5_YDR146C_1770349_at 0.27633 29.40695 0.998062 NA NA NA ACE2_YLR131C_1771312_at SWI5_YDR146C_1770349_at 1.322992 0 0.998062 NA YLR131C <->YDR146C NA SWI5_YDR146C_1770349_at ACE2_YLR131C_1771312_at 0.440266 0 0.996918 NA YDR146C <->YLR131C NA YHP1_YDR451C_1778368_at ACE2_YLR131C_1771312_at...”
- More
AFUA_7G03910, Afu7g03910 C2H2 zinc finger protein from Aspergillus fumigatus Af293
48% identity, 12% coverage
- Distinct Cohorts of Aspergillus fumigatus Transcription Factors Are Required for Epithelial Damage Occurring via Contact- or Soluble Effector-Mediated Mechanisms
Rahman, Frontiers in cellular and infection microbiology 2022 - “...and Braus, 2005 AFUB_033930 AFUA_3G15290 2A3 (BGC12) Secondary metabolite production Bignell et al. 2016 AFUB_089440 AFUA_7G03910 5H5 ( nsdC ) Early stage of mating de Castro etal. 2021 AFUB_005510 AFUA_1G05150 1A12 Unknown CELL LYSIS TFKOs AFUB number AFUA number TF number /Generic name Main Function References...”
- Genome-Wide Association Analysis for Triazole Resistance in Aspergillus fumigatus
Fan, Pathogens (Basel, Switzerland) 2021 - “...factors ( ace1, AFUA_1G02870, AFUA_1G04140, AFUA_1G16460, AFUA_2G01190, AFUA_3G09130, AFUA_4G06170, AFUA_4G13600, AFUA_5G02655, AFUA_5G06350, AFUA_5G07510, AFUA_6G01960, AFUA_6G03430, AFUA_7G03910, AFUA_8G07360 , and fumR ) were overexpressed following itraconazole exposure [ 21 , 35 ]. Similarly, five ABC transporters ( mdr1 , abcB , abcC , abcD and abcE ),...”
- “...>1.50~5.50 [ 38 ] AFUA_1G16460 BZIP transcription factor (LziP), putative 1.752.12 NA [ 39 ] AFUA_7G03910 C2H2 zinc finger protein 2.502.86 NA [ 39 ] ace1 (AFUA_3G08010) C2H2 zinc-finger transcription factor, putative 1.662.32 NA [ 39 ] AFUA_4G13600 2.302.71 NA [ 39 ] zfpA (AFUA_8G05010) NA...”
- Novel Biological Functions of the NsdC Transcription Factor in Aspergillus fumigatus
Alves, mBio 2021 - “...sensitivity to 500mM calcium chloride ( 30 ). Among these TF mutants, we observed nsdC (Afu7g03910), a putative homologue of A. nidulans NsdC (AN4263), a C 2 H 2 zinc finger TF required for sexual development ( 29 ). In order to investigate the function of...”
- Fungal oxylipins direct programmed developmental switches in filamentous fungi
Niu, Nature communications 2020 - “...to right are: <0.0001, 0.0005, <0.0001, 0.0026, 0.0038, 0.0041, 0.0105. c Expression of AFUA_8G05010 and AFUA_7G03910 at 30- and 120 min post treatment and AFUA_2G15110 and AFUA_4G11480 at 30min post treatment ( n =4) through quantitative real-time PCR (qRT-PCR). The total RNA was extracted from four...”
- “...from the RNA-seq results with quantitative RT-PCR in Af293: AFUA_8G05010 ( AFUB_082490 in CEA10) and AFUA_7G03910 ( AFUB_089440 in CEA10) were significantly upregulated, and AFUA_4G11480 ( AFUB_068500 in CEA10) and AFUA_2G15110 ( AFUB_030770 in CEA10) were significantly downregulated (Fig. 5c and Supplementary Table 2 ). AFUB_089440...”
- Aspergillus fumigatus calcium-responsive transcription factors regulate cell wall architecture promoting stress tolerance, virulence and caspofungin resistance
de, PLoS genetics 2019 - “...mutants exhibited increased sensitivity to 500 mM calcium [Afu1g10550, Afu5g10620, Afu6g12522 ( skn7 ), Afu4g07090, Afu7g03910 ( nsdC ), and as previously described Afu2g03280 ( zipD ) Afu1g06900 ( crzA )] [ 26 32 ], while two mutants showed increased tolerance [Afu1g13190 and Afu3g08010 ( ace1...”
- “...[ 32 ]. The genes Afu1g10550, Afu5g10620, Afu4g07090 are without any known functional annotation, whereas Afu7g03910 ( nsdC ) is the A . nidulans NsdC homologue required for sexual development [ 53 ]. Finally, Afu6g12522 ( skn7 ) contributes to growth in the presence of hydrogen...”
CTRG_03621 predicted protein from Candida tropicalis MYA-3404
45% identity, 14% coverage
- A Multistate Toggle Switch Defines Fungal Cell Fates and Is Regulated by Synergistic Genetic Cues
Anderson, PLoS genetics 2016 - “...and ZCF22 , showed elevated expression in white cells, whereas UME6 , TAN1 , and CTRG_03621 showed elevated expression in opaque cells ( Fig 2D ). Thus, the three cell states express unique sets of genes with a number of differentially expressed transcription factors. Furthermore, comparison...”
- “...Homozygous deletion mutants were obtained for all targeted genes with the exception of ZCF22 and CTRG_03621 , which could represent essential genes. Although previous work has established that deletion of C . tropicalis WOR1 or EFG1 promotes formation of the white or opaque state, respectively [...”
FGSG_01350 hypothetical protein from Fusarium graminearum PH-1
47% identity, 12% coverage
- Functional Characterization of Calcineurin-Responsive Transcription Factors Fg01341 and Fg01350 in Fusarium graminearum
Zhang, Frontiers in microbiology 2020 - “...identity and an E values of 1e-51 with S. cerevisiae Crz1; it was followed by FGSG_01350 (54.4% and an E values of 6.8e-17) and FGSG_13711 (FgCrz1A, 34% and an E values of 0.0016). The identity sequences were mainly located in the two C2H2 zinc finger domains...”
- “...partially deduced Crz1 amino acid sequences of S. cerevisiae , BCIN_01g08230, and CNAG_00156 and FGSG_01341, FGSG_01350, and FGSG_13711. The two conserved C2H2 zinc finger domains were labeled. (B) Phylogenetic analysis of FGSG_01341 , FGSG_01350 , and other homologs from other fungal species. The phylogenetic tree was...”
- RNA-Seq Revealed Differences in Transcriptomes between 3ADON and 15ADON Populations of Fusarium graminearum In Vitro and In Planta
Puri, PloS one 2016 - “...zinc finger domains identified in F . graminerum genome [ 52 ], eight (FGSG_00764, FGSG_01298, FGSG_01350, FGSG_04288, FGSG_06701, FGSG_10350, FGSG_10470, FGSG_13964) were exclusively up-regulated in the 3ADON population ( S4 Table ). The function of the C2H2 zinc finger proteins in F . graminearum is unknown,...”
- Genomic clustering and co-regulation of transcriptional networks in the pathogenic fungus Fusarium graminearum
Lawler, BMC systems biology 2013 - “...1 FG6 FGSG_13911 Myb_DNA-binding 1 FG2.01 FGSG_01298 zf-C2H2 1 FG6 FGSG_01341 zf-C2H2 2 FG1, FG2.10 FGSG_01350 zf-C2H2 2 FG1, FG2.10 FGSG_02743 zf-C2H2 2 FG1, FG2.10 FGSG_06311 zf-C2H2 1 FG6 FGSG_06871 zf-C2H2 4 FG1, FG2.-10, FG2.-11, FG6 FGSG_12970 zf-C2H2 1 FG6 FGSG_08010 Zn_clus 2 FG1, FG2.10 The...”
- A phenome-based functional analysis of transcription factors in the cereal head blight fungus, Fusarium graminearum
Son, PLoS pathogens 2011 - “...Reduced Reduced None FGSG_07067 GzZC232 None Reduced Reduced Normal FGSG_06071 GzAT001 None Reduced Reduced Normal FGSG_01350 GzC2H014 None Reduced Reduced Reduced FGSG_06871 GzC2H045 None Reduced Reduced Normal FGSG_00324 GzMyb002 None Reduced Reduced Reduced FGSG_10069 GzZC087 None Reduced Reduced Normal FGSG_00574 GzZC302 None Reduced Reduced Normal FGSG_04220...”
XP_006139884 Krueppel-like factor 5 from Tupaia chinensis
46% identity, 25% coverage
LOC410326 Krueppel-like factor 10 from Apis mellifera
39% identity, 19% coverage
ACE2_CANGA / Q6FJQ9 Cell wall transcription factor ACE2 from Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138) (Yeast) (Nakaseomyces glabratus) (see 4 papers)
43% identity, 10% coverage
- function: Transcription factor involved in the RAM (regulation of ACE2 transcription factor and polarized morphogenesis) signaling network that regulates polarized morphogenesis. Regulates expression of genes involved in cell separation or other cell wall genes. Required for regulation of morphogenesis, cell separation, adherence, biofilm formation, invasion, as well as virulence.
disruption phenotype: Leads to systemic infections characterized by fungal escape from the vasculature, tissue penetration, proliferation in vivo, and considerable overstimulation of the pro-inflammatory arm of the innate immune response.
NP_650534 poils au dos from Drosophila melanogaster
39% identity, 8% coverage
MGG_00504 zinc finger protein 740 from Pyricularia oryzae 70-15
47% identity, 11% coverage
NP_997827 transcription factor Sp1 from Danio rerio
37% identity, 13% coverage
- A clustered set of three Sp-family genes is ancestral in the Metazoa: evidence from sequence analysis, protein domain structure, developmental expression patterns and chromosomal location
Schaeper, BMC evolutionary biology 2010 - “...NP_569725 ], Mm _Sp8 [GenBank: NP_796056 ], Mm _Sp9 [GenBank: NP_001005343 ], Dr _Sp1 [GenBank: NP_997827 ], Dr _Sp2 [GenBank: NP_001093452 ], Dr _Sp3 [GenBank: NP_001082967 ], Dr _Sp3-like [GenBank: XP_691096 ], Dr _Sp4 [GenBank: NP_956418 ], Dr _Sp5 [GenBank: NP_851304 ], Dr _Sp5-like [GenBank: NP_919352...”
CTRG_03073 hypothetical protein from Candida tropicalis MYA-3404
44% identity, 10% coverage
- Transcriptional Control of Drug Resistance, Virulence and Immune System Evasion in Pathogenic Fungi: A Cross-Species Comparison
Pais, Frontiers in cellular and infection microbiology 2016 - “...2014 ). BLASTp analysis unveiled yet another Ace2 homolog in C. tropicalis encoded by ORF CTRG_03073 . Despite not sharing significant homology, A. fumigatus also harbors an Ace2 protein, sharing the C 2 H 2 zinc finger domain. As the remaining regulators, A. fumigatus Ace2 is...”
- “...( A. fumigatus ) Ace2 ( C. albicans ) Ace2 ( C. parapsilosis ) N.A. CTRG_03073 * Ace2 ( C. glabrata ) Ace2 ( A. fumigatus ) Virulence (nitrogen use) Gat1 ( C. albicans ) N.A. N.A. Gat1; CTRG_03831 * AreA ( A. fumigatus ) Virulence...”
XP_010740989 Krueppel-like factor 4 isoform X1 from Larimichthys crocea
46% identity, 16% coverage
nsdC NSDC from Emericella nidulans (see paper)
47% identity, 12% coverage
- CharProtDB Description: C2H2 zinc finger transcription factor; required for sexual development; vegetative growth reduced and asexual development derepressed in null mutant; mRNA increased during sexual development and under hypoxic conditions; Source:AspGD
CPAR2_204370 uncharacterized protein from Candida parapsilosis
42% identity, 8% coverage
- The Pathogenic Yeast Candida parapsilosis Forms Pseudohyphae through Different Signaling Pathways Depending on the Available Carbon Source
Rupert, mSphere 2022 - “...CZF1 CCTCATCCGTACCAACAAC GACGGCATGTGAGACATCCC CPAR2_805930 TEC1 GCCAGAACTTCGATACCCGC GACCAGCGTCCAAACCTTG CPAR2_601080 FLO8 CTTCGTCAAATGCAACGGGG GTTGCCACCACCACCAAGAC CPAR2_803820 UME6 CAAATCGACGCCGTTATTGCC CCGAACCTGACACAAGCCCC CPAR2_204370 ACE2 CGACATTTAAAGGGCCACAG CCATGCCCTTTACCCCACC CPAR2_109520 TUP1 GCTGCTGGATCTTTAGATCGC CTATCCAATGACCCTGAAGC CPAR2_300790 NRG1 CCATGGCCTACATGTGATGC CCCCATAACCAGTATGACCG CPAR2_803890 MLS1 CCAGGAGGTGTCATTACTG CACCATGAGTGACCCATTGC CPAR2_106400 GSC1 GGCAAGCTCCATTGTTGTGG GTGCCACTTGGTGTTACCTC CPAR2_403180 PGA62 CCAACCACTCAAACCACCG GAACAGACTTGGCGGCACCG CPAR2_803900 HST1 CGGAGCTACGGGAGTATAAAG CTCCAATGTACCGCACCTAC Virulence assay. Virulence...”
- The transcription factor Ndt80 is a repressor of Candida parapsilosis virulence attributes
Branco, Virulence 2021 - “...), MKC1 ( CPAR2_800090 ), CPH2 ( CPAR2_603440 ), RHR2 ( CPAR2_503990 ), ACE2 ( CPAR2_204370 ), CPH2 ( CPAR2_603440 ), UME6 ( CPAR2_803820 ) and CZF1 ( CPAR2_501290 ). For each real-time quantitative PCR, five replicates per strain were analyzed. All primers used are detailed...”
LOC100642767 Krueppel-like factor 10 from Bombus terrestris
39% identity, 19% coverage
NP_001082967 transcription factor Sp3a from Danio rerio
38% identity, 11% coverage
- A clustered set of three Sp-family genes is ancestral in the Metazoa: evidence from sequence analysis, protein domain structure, developmental expression patterns and chromosomal location
Schaeper, BMC evolutionary biology 2010 - “...NP_001005343 ], Dr _Sp1 [GenBank: NP_997827 ], Dr _Sp2 [GenBank: NP_001093452 ], Dr _Sp3 [GenBank: NP_001082967 ], Dr _Sp3-like [GenBank: XP_691096 ], Dr _Sp4 [GenBank: NP_956418 ], Dr _Sp5 [GenBank: NP_851304 ], Dr _Sp5-like [GenBank: NP_919352 ], Dr _Similar_to_Sp5 [GenBank: XP_001335730 ], Dr _Sp6 [GenBank: NP_991195...”
SNAI1_XENLA / P19382 Protein snail homolog Sna; Protein Xsnail; Protein xSna from Xenopus laevis (African clawed frog) (see 4 papers)
NP_001079925 protein snail homolog Sna from Xenopus laevis
43% identity, 29% coverage
- function: Transcriptional repressor. Acts upstream of snai2/slug, zic5 and other neural crest markers in the specification of the neural crest and neural crest migration. Involved in embryonic mesoderm formation.
subunit: Interacts (via SNAG domain) with limd1 (via LIM domains), wtip (via LIM domains) and ajuba (via LIM domains) (PubMed:18331720). Interacts with elp3; the interaction inhibits snai1 ubiquitination and promotes snai1 stability (PubMed:27189455). - PAPC mediates self/non-self-distinction during Snail1-dependent tissue separation.
Luu, The Journal of cell biology 2015 - GeneRIF: The transcription factor Snail1 is essential for tissue separation, enabling paraxial protocadherin (PAPC) to promote tissue separation through novel functions.
- Interactions between Twist and other core epithelial-mesenchymal transition factors are controlled by GSK3-mediated phosphorylation.
Lander, Nature communications 2013 - GeneRIF: Interaction with Snail1/2, and Twist function more generally, is regulated by GSK-3-beta-mediated phosphorylation of conserved sites in the WR domain.
- The F-box protein Ppa is a common regulator of core EMT factors Twist, Snail, Slug, and Sip1.
Lander, The Journal of cell biology 2011 - GeneRIF: the same E3 ubiquitin ligase known to regulate Snail family proteins, Partner of paired (Ppa), also controlled Twist stability and did so in a manner dependent on the Twist WR-rich domain
ZIC3_MOUSE / Q62521 Zinc finger protein ZIC 3; Zinc finger protein of the cerebellum 3 from Mus musculus (Mouse) (see 4 papers)
42% identity, 15% coverage
- function: Acts as a transcriptional activator. Required in the earliest stages in both axial midline development and left-right (LR) asymmetry specification. Binds to the minimal GLI-consensus sequence 5'-GGGTGGTC- 3'.
subunit: Interacts with KPNA1 and KPNA6. Interacts (via C2H2-type domains 3, 4 and 5) with GLI3; the interaction enhances its transcriptional activity (By similarity). Interacts (via the C2H2-type domains 3, 4 and 5) with MDFIC (via the C2H2-type domains 3, 4 and 5); the interaction reduces its transcriptional activity.
disruption phenotype: Some mice exhibit embryonic and postnatal lethality. Viable mice show heart disease, disturbances of laterality, neural tube defects and vertebral and rib defects.
ZIC3_HUMAN / O60481 Zinc finger protein ZIC 3; Zinc finger protein 203; Zinc finger protein of the cerebellum 3 from Homo sapiens (Human) (see 7 papers)
NP_003404 zinc finger protein ZIC 3 isoform 1 from Homo sapiens
42% identity, 15% coverage
- function: Acts as a transcriptional activator. Required in the earliest stages in both axial midline development and left-right (LR) asymmetry specification. Binds to the minimal GLI-consensus sequence 5'-GGGTGGTC- 3'.
subunit: Interacts (via the C2H2-type domains 3, 4 and 5) with MDFIC (via the C2H2-type domains 3, 4 and 5); the interaction reduces its transcriptional activity (By similarity). Interacts with KPNA1 and KPNA6. Interacts (via C2H2-type domains 3, 4 and 5) with GLI3; the interaction enhances its transcriptional activity. - Zic family member 3 attenuates oxidative stress-induced vascular smooth muscle cell apoptosis in patients with chronic kidney disease.
Gao, Tissue & cell 2024 (PubMed)- GeneRIF: Zic family member 3 attenuates oxidative stress-induced vascular smooth muscle cell apoptosis in patients with chronic kidney disease.
- ZIC2 and ZIC3 promote SWI/SNF recruitment to safeguard progression towards human primed pluripotency.
Hossain, Nature communications 2024 - GeneRIF: ZIC2 and ZIC3 promote SWI/SNF recruitment to safeguard progression towards human primed pluripotency.
- A novel ZIC3 mutation in a Chinese family with heterotaxy and multiple types of congenital heart defect.
Wang, Prenatal diagnosis 2023 (PubMed)- GeneRIF: A novel ZIC3 mutation in a Chinese family with heterotaxy and multiple types of congenital heart defect.
- Description of a family with X-linked oculo-auriculo-vertebral spectrum associated with polyalanine tract expansion in ZIC3.
Trimouille, Clinical genetics 2020 (PubMed)- GeneRIF: Description of a family with X-linked oculo-auriculo-vertebral spectrum associated with polyalanine tract expansion in ZIC3.
- miR-155-5p inhibits the viability of vascular smooth muscle cell via targeting FOS and ZIC3 to promote aneurysm formation.
Zhao, European journal of pharmacology 2019 (PubMed)- GeneRIF: miR-155-5p inhibits the viability of vascular smooth muscle cell via targeting FOS and ZIC3 to promote aneurysm formation
- ZIC3 in Heterotaxy.
Bellchambers, Advances in experimental medicine and biology 2018 - GeneRIF: current understanding of ZIC3 function and describe the potential role ZIC3 plays in important signalling pathways and their links to heterotaxy.
- A novel ZIC3 gene mutation identified in patients with heterotaxy and congenital heart disease.
Li, Scientific reports 2018 - GeneRIF: The results of functional indicated that this ZIC3 mutation decreases transcriptional activity, affects the affinity of the GLI-binding site and results in aberrant cellular localization in transfected cells.
- An Evolutionarily Conserved Mesodermal Enhancer in Vertebrate Zic3.
Odaka, Scientific reports 2018 - GeneRIF: This study characterized cis-regulatory elements required for Zic3 expression.
- More
- Systematic Analysis of the Genetic Variability That Impacts SUMO Conjugation and Their Involvement in Human Diseases.
Xu, Scientific reports 2015 - “...K171 DRNKKKKEVP K P ECSESYTLT UniProtKB dbSNP Regulates its subcellular localization and transcriptional activity ZIC3 (O60481) Lys248Arg K248 AFFRYMRQPI K Q ELSCKWIDE Experimental verification Regulates nuclear localization and function of zinc finger transcription factor ZIC3 Type I (+) SUMOAMVRs CASP8AP2 (Q9UKL3) Gln1792Lys K1792 ANRPLKCIVE E T...”
- A survey of well conserved families of C2H2 zinc-finger genes in Daphnia
Seetharam, BMC genomics 2010 - “...ZIC ZIC1 (Q15915) OPA (P39768) REF2 (Q94178) OPA (Dappu-290567) 104:131019-135418 ZIC2 (O95409) SUG (Q7K0S9) ZIC3 (O60481) ZIC4(Q8N9L1) ZIC5(Q96T25) OVO OVOL1 (O14753) OVOrb (P51521) LIN48 (Q19996) OVO (Dappu-290491) 191:57-1323 OVOL2 (Q9BRP0) SNAIL SNAIL3 (NP_840101) SNAIL (P08044) K02D7 (NP_499902) Dappu- 53927 39:954341-955431 SNAIL2 (O43623) ESG (P25932) SCRT1(NP_491001) Dappu-...”
XP_003220701 zinc finger protein SNAI1 from Anolis carolinensis
43% identity, 29% coverage
NP_990473 zinc finger protein SNAI1 from Gallus gallus
43% identity, 30% coverage
KRUP_DROME / P07247 Protein krueppel from Drosophila melanogaster (Fruit fly) (see paper)
NP_001261181 kruppel, isoform B from Drosophila melanogaster
44% identity, 15% coverage
- function: Krueppel is a gap class segmentation protein. It is involved in the segmentation of the embryo and in the differentiation of the Malpighian tubules
- Multifaceted effects on even-skipped transcriptional dynamics upon Krüppel dosage changes.
Lin, Development (Cambridge, England) 2024 - GeneRIF: Multifaceted effects on even-skipped transcriptional dynamics upon Kruppel dosage changes.
- Spatial distribution of predicted transcription factor binding sites in Drosophila ChIP peaks.
Pettie, Mechanisms of development 2016 - GeneRIF: In this study, ChIP/chip datasets are analyzed using the corresponding PWMs for the well-studied TFs; CAUDAL, HUNCHBACK, KNIRPS and KRUPPEL, to determine the distribution of predicted binding sites. All four TFs are critical regulators of gene expression along the anterio-posterior axis in early Drosophila development
- Neuronal cell fate diversification controlled by sub-temporal action of Kruppel.
Stratmann, eLife 2016 - GeneRIF: Surprisingly, the early temporal gene Kruppel acts as one of the sub-temporal genes within the late castor window.
- Mid-embryo patterning and precision in Drosophila segmentation: Krüppel dual regulation of hunchback.
Holloway, PloS one 2015 - GeneRIF: Kr regulation can limit the positional variability of the Hb mid-embryo border.
- Krüppel mediates the selective rebalancing of ion channel expression.
Parrish, Neuron 2014 - GeneRIF: Kruppel induction is specific to the loss of Shal, a potassium channel mutant.
- SAP18 promotes Krüppel-dependent transcriptional repression by enhancer-specific histone deacetylation.
Matyash, The Journal of biological chemistry 2009 (PubMed)- GeneRIF: Kruppel tethers the SAP18 bound histone deacetylase complex 1 at distinct enhancer elements, which causes repression via histone H3 deacetylation
- Breakdown of abdominal patterning in the Tribolium Kruppel mutant jaws.
Cerny, Development (Cambridge, England) 2005 (PubMed)- GeneRIF: The segmentation function of Kruppel in Tribolium is fundamentally different from its role in the long-germ embryo of Drosophila.
- Krüppel homolog 1 (Kr-h1) mediates juvenile hormone action during metamorphosis of Drosophila melanogaster.
Minakuchi, Mechanisms of development - GeneRIF: Kr-h1 mediates some of the JH signaling in the adult abdominal epidermis and is upstream of broad protein in this pathway
NP_084496 transcription factor Sp2 isoform 1 from Mus musculus
38% identity, 12% coverage
- A clustered set of three Sp-family genes is ancestral in the Metazoa: evidence from sequence analysis, protein domain structure, developmental expression patterns and chromosomal location
Schaeper, BMC evolutionary biology 2010 - “...NP_874359 ], Hs _Sp9 [GenBank: NP_001138722 ], Mm _Sp1 [GenBank: NP_038700 ], Mm _Sp2 [GenBank: NP_084496 ], Mm _Sp3 [GenBank: NP_035580 ], Mm _Sp4 [GenBank: NP_033265 ], Mm _Sp5 [GenBank: NP_071880 ], Mm _Sp6 [GenBank: NP_112460 ], Mm _Sp7 [GenBank: NP_569725 ], Mm _Sp8 [GenBank: NP_796056...”
- A conserved function of the zinc finger transcription factor Sp8/9 in allometric appendage growth in the milkweed bug Oncopeltus fasciatus
Schaeper, Development genes and evolution 2009 - “...values. GenBank accession numbers: Dm_btd NP_511100, D-Sp1 NP_572579, Tc_btd NP_001107792, Tc_Sp8 NP_001034509, Mm_Sp1 NP_038700, Mm_Sp2 NP_084496, Mm_Sp3 NP_035580, Mm_Sp4 NP_033265, Mm_Sp5 NP_071880, Mm_Sp6 NP_112460, Mm_Sp7 NP_569725, Mm_Sp8 NP_796056, Mm_Sp9 NM_001005343. Species abbreviations: Mm Mus musculus , Tc Tribolium castaneum , Of Oncopeltus fasciatus , Dm Drosophila...”
XP_011523441 transcription factor Sp2 isoform X6 from Homo sapiens
38% identity, 12% coverage
- Transcription factor Sp2 promotes TGFB-mediated interstitial cell osteogenic differentiation in bicuspid aortic valves through a SMAD-dependent pathway.
Zheng, Experimental cell research 2022 (PubMed)- GeneRIF: Transcription factor Sp2 promotes TGFB-mediated interstitial cell osteogenic differentiation in bicuspid aortic valves through a SMAD-dependent pathway.
- Transcription Factor SP2 Regulates Ski-mediated Astrocyte Proliferation In Vitro.
Da, Neuroscience 2021 (PubMed)- GeneRIF: Transcription Factor SP2 Regulates Ski-mediated Astrocyte Proliferation In Vitro.
- Sp2 promotes invasion and metastasis of hepatocellular carcinoma by targeting TRIB3 protein.
Zhu, Cancer medicine 2020 - GeneRIF: Sp2 promotes invasion and metastasis of hepatocellular carcinoma by targeting TRIB3 protein.
- Novel Mutation (Gly212Val) in the PS2 Gene Associated with Early-Onset Familial Alzheimer's Disease.
Marín-Muñoz, Journal of Alzheimer's disease : JAD 2016 (PubMed)- GeneRIF: This study presented that a Novel Mutation (Gly212Val) in the PS2 Gene Associated with Early-Onset Familial Alzheimer's Disease.
- Expression of human gene coding RORγT receptor depends on the Sp2 transcription factor.
Ratajewski, Journal of leukocyte biology 2016 (PubMed)- GeneRIF: SP2 recognized binding motifs in the human RORgammaT promoter, which was critical for maintaining expression. SP2 was necessary for maximum IL-17 expression in in vitro-differentiated Th17 cells. SP 2 plays a role in Th17-dependent physiologic and pathologic immune responses.
- O-GlcNAc modification of Sp3 and Sp4 transcription factors negatively regulates their transcriptional activities.
Ha, Biochemical and biophysical research communications 2015 (PubMed)- GeneRIF: O-GlcNAc modification of Sp3 and Sp4, but not Sp2 transcription factors negatively regulates their transcriptional activities.
- miR-638 suppresses cell proliferation in gastric cancer by targeting Sp2.
Zhao, Digestive diseases and sciences 2014 (PubMed)- GeneRIF: Sp2 is up-regulated in gastric cancer tissues
- Sp2 regulates interferon-gamma-mediated socs1 gene expression.
Letourneur, Molecular immunology 2009 (PubMed)- GeneRIF: Despite the absence of Sp2 in the 5'-upstream sequence of the human promoter, silencing of Sp2 by RNA interference clearly demonstrated that Sp2 is required for IFN-gamma-induced regulation of socs1 mRNA both in human and mouse.
- More
SP2_HUMAN / Q02086 Transcription factor Sp2 from Homo sapiens (Human) (see paper)
NP_003101 transcription factor Sp2 from Homo sapiens
38% identity, 12% coverage
- function: Binds to GC box promoters elements and selectively activates mRNA synthesis from genes that contain functional recognition sites
- Functionally Annotating Regulatory Elements in the Equine Genome Using Histone Mark ChIP-Seq.
Kingsley, Genes 2019 - “...Q02447 5 NEUROD1 NRACAGATGGYNN 1.60 10 3 Q13562 Lamina 1 SP2 GYCCCGCCYCYBSSS 8.51 10 15 Q02086 2 SP1 GCCCCKCCCCC 5.98 10 14 P08047 3 SP3 VCCACGCCCMC 2.84 10 13 Q02447 4 KLF16 GMCACGCCCCC 3.22 10 13 Q9BXK1 7 Zfx SSSGCCBVGGCCTS 1.06 10 11 P17010 Liver 1...”
- “...P05549 Muscle 1 SP1 GCCCCKCCCCC 1.45 10 9 P08047 2 SP2 GYCCCGCCYCYBSSS 4.21 10 9 Q02086 3 SP8 RCCACGCCCMCY 1.15 10 8 Q8IXZ3 4 CTCFL CRSCAGGGGGCRSB 3.44 10 8 Q8NI51 5 KLF16 GMCACGCCCCC 4.36 10 7 Q9BXK1 Ovary 1 FOXO3 1 DAAAYA 7.23 10 7 O43524...”
- SP and KLF Transcription Factors in Digestive Physiology and Diseases.
Kim, Gastroenterology 2017 - “...proteins used for this figure are listed per UniProtKB database as follows: SP1 (P08047), SP2 (Q02086), SP3 (Q02447), SP4 (Q02446), SP5 (Q6BEB4), SP6 (Q3SY56), SP7 (Q87DD2), SP8 (Q8IXZ3), SP9 (P0CG40), KLF1 (Q13351), KLF2 (Q9Y5W3), KLF3 (P57682), KLF4 (Q43474), KLF5 (Q13887), KLF6 (Q99612), KLF7 (O75840), KLF8 (O95600),...”
- FCGR2A Promoter Methylation and Risks for Intravenous Immunoglobulin Treatment Responses in Kawasaki Disease.
Kuo, Mediators of inflammation 2015 - “...CAGGATGGTCTC I USF1 BAA76541 5.780 0.85 ATCTCCTGACC Myc-Max AAH36092 8.449 0.81 GACCTCGTGAT J * SP2 Q02086 6.046 0.81 CACCCGCCTTGGCCT K * * The corresponding CpG sites reached the statistical significance in Table 2 or Table 3 . a Accession number is the NCBI protein accession number....”
- Krüppel-like factors in cancer progression: three fingers on the steering wheel.
Limame, Oncotarget 2014 - “...# amino acids Molecular weight (kDa) SP1 TFSP1 BC062539 P08047 785 80.7 SP2 KIAA0048 NM_003110 Q02086 613 64.9 SP3 SPR-2 AY070137 Q02447 781 81.9 SP4 SPR-1,HF1B, MGC130008, MGC130009 NM_003112 Q02446 784 82 SP5 AB096175 Q6BEB4 398 42 SP7 OSX BC113613 Q8TDD2 431 45 SP8 BC038669 Q8IXZ3...”
- Transcriptome analysis of head kidney in grass carp and discovery of immune-related genes.
Chen, BMC veterinary research 2012 - “...Cluster1088 fucolectin Q7SIC1 1 Cluster1225 endoplasmic reticulum aminopeptidase 1 Q9NZ08 1 Cluster1249 transcription factor sp2 Q02086 1 Cluster1357 complement c3 P98093 1 Cluster1410 b-cell lymphoma 6 protein homolog P41183 1 Cluster1474 matrix metalloproteinase-9 P14780 1 Cluster1562 serine threonine-protein phosphatase subunit P30153 1 Cluster1638 inosine-5 -monophosphate dehydrogenase...”
- A survey of well conserved families of C2H2 zinc-finger genes in Daphnia
Seetharam, BMC genomics 2010 - “...D. pulex , v1.1) SP SP1 (P08047) BTD (Q24266) SPTF1 (NP_001021466) SP5 (Dappu-114437) scaffold_130:263756-265967 SP2 (Q02086) DSp1 (NP_727360) SPTF2 (NP_495833) SP1 (Dappu-315784) scaffold_15:792601-795915 SP3/SPR2 (Q02447) CG5669 (NP_651232) SPTF3 (NP_493353) SP8 (Dappu-106303) scaffold_42:141432-144224 SP4/SPR1 (Q02446) SP5 (Q6BEB4) SP6/KLF14 (Q3SY56) SP7 (Q8TDD2) SP8 (Q8IXZ3) KLF KLF1 (Q13351) CG12029...”
- An insight into the phylogenetic history of HOX linked gene families in vertebrates
Abbasi, BMC evolutionary biology 2007 - “...c2h2-type zinc-finger protein family SP1 12q13.1 P08047 RNA polymerase II transcription factor activity. SP2 17q21.32 Q02086 SP3 2q31 Q02447 SP4 7p15 Q02446 SP8 7p21.2 Q8IXZ3 Zinc finger protein, subfamily 1A ZNFN1A1 7p13-p11.1 Q13422 DNA-dependent regulation of transcription, Specification and the maturation of the lymphocyte. ZNFN1A2 2qter...”
- A clustered set of three Sp-family genes is ancestral in the Metazoa: evidence from sequence analysis, protein domain structure, developmental expression patterns and chromosomal location
Schaeper, BMC evolutionary biology 2010 - “...XP_789110.1 ], Sp _Sp6-9 [GenBank: XP_793203.2 ], Hs _Sp1 [GenBank: NP_612482 ], Hs _Sp2 [GenBank: NP_003101 ], Hs _Sp3 [GenBank: NP_003102 ], Hs _Sp4 [GenBank: NP_003103 ], Hs _Sp5 [GenBank: NP_001003845 ], Hs _Sp6 [GenBank: NP_954871 ], Hs _Sp7 [GenBank: NP_690599 ], Hs _Sp8 [GenBank: NP_874359...”
NP_651232 Sp1-like factor for pairing sensitive-silencing, isoform A from Drosophila melanogaster
36% identity, 8% coverage
- A survey of well conserved families of C2H2 zinc-finger genes in Daphnia
Seetharam, BMC genomics 2010 - “...SP5 (Dappu-114437) scaffold_130:263756-265967 SP2 (Q02086) DSp1 (NP_727360) SPTF2 (NP_495833) SP1 (Dappu-315784) scaffold_15:792601-795915 SP3/SPR2 (Q02447) CG5669 (NP_651232) SPTF3 (NP_493353) SP8 (Dappu-106303) scaffold_42:141432-144224 SP4/SPR1 (Q02446) SP5 (Q6BEB4) SP6/KLF14 (Q3SY56) SP7 (Q8TDD2) SP8 (Q8IXZ3) KLF KLF1 (Q13351) CG12029 (NP_647822) KLF1 (NP_497632) KLF1A (Dappu-48391) scaffold_16:1551074-1551469 KLF2 (Q9Y5W3) CG9895 (NP_611747) F53F8.1...”
- A clustered set of three Sp-family genes is ancestral in the Metazoa: evidence from sequence analysis, protein domain structure, developmental expression patterns and chromosomal location
Schaeper, BMC evolutionary biology 2010 - “...the three zinc fingers (in red). Accession numbers of used Sp proteins: Dm_ CG5669 [GenBank: NP_651232 ], Dm_ Btd [GenBank: NP_511100 ], Dm_ D-Sp1 [GenBank: NP_572579 ], Dps_ GA19045 [GenBank: XP_001358829 ], Dps_ GA22354 [GenBank: XP_002134535 ], Dps _GA12282 [GenBank: XP_001354397 ], Ag _Sp1-4 [GenBank: NZ_AAAB02008898...”
- Spps, a Drosophila Sp1/KLF family member, binds to PREs and is required for PRE activity late in development.
Brown, Development (Cambridge, England) 2010 - GeneRIF: Spps, a Drosophila Sp1/KLF family member, binds to PREs and is required for PRE activity late in development
NP_571931 Krueppel-like factor 2a from Danio rerio
47% identity, 19% coverage
- Primary cilia mediate Klf2-dependant Notch activation in regenerating heart.
Li, Protein & cell 2020 - GeneRIF: Primary cilia mediate Klf2-dependant Notch activation in regenerating heart.
- Mechanically activated piezo channels modulate outflow tract valve development through the Yap1 and Klf2-Notch signaling axis.
Duchemin, eLife 2019 - GeneRIF: Piezo controls Klf2 and Notch activity in the endothelium and Yap1 localization in the smooth muscle progenitors to coordinate zebrafish outflow tract valve morphogenesis.
- Heg1 and Ccm1/2 proteins control endocardial mechanosensitivity during zebrafish valvulogenesis.
Donat, eLife 2018 - GeneRIF: In turn, Heg1 stabilizes levels of Krit1 protein, and both Heg1 and Krit1 dampen expression levels of klf2a, a major mechanosensitive gene. The correct balance of blood-flow-dependent induction and Krit1 protein-mediated repression of klf2a and notch1b ultimately shapes cardiac valve leaflet morphology.
- Blood Flow Regulates Zebrafish Caudal Vein Plexus Angiogenesis by ERK5-klf2a-nos2b Signaling.
Xie, Current molecular medicine 2018 (PubMed)- GeneRIF: The data suggest that flow-induced ERK5-klf2a-nos2b signaling is involved in CVP angiogenesis in zebrafish embryos.
- The flow responsive transcription factor Klf2 is required for myocardial wall integrity by modulating Fgf signaling.
Rasouli, eLife 2018 - GeneRIF: These studies provide new insights into how Klf2 regulates cardiovascular development and specifically myocardial wall integrity.
- klf2a couples mechanotransduction and zebrafish valve morphogenesis through fibronectin synthesis.
Steed, Nature communications 2016 - GeneRIF: Heart valves originate from progenitors located in the ventricle and atrium that generate the valve leaflets through a coordinated set of endocardial tissue movements, dependent on the expression of fibronectin1b. Blood flow and klf2a control these cell behaviours and fibronectin1b synthesis.
- Regulation of β1 integrin-Klf2-mediated angiogenesis by CCM proteins.
Renz, Developmental cell 2015 (PubMed)- GeneRIF: reveals a beta1 integrin-Klf2-Egfl7-signaling pathway that is tightly regulated by cerebral cavernous malformation proteins
- Oscillatory Flow Modulates Mechanosensitive klf2a Expression through trpv4 and trpp2 during Heart Valve Development.
Heckel, Current biology : CB 2015 (PubMed)- GeneRIF: Oscillatory flow modulates mechanosensitive klf2a expression through trpv4 and trpp2 during heart valve development.
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XP_010567958 zinc finger protein SNAI1 from Haliaeetus leucocephalus
43% identity, 30% coverage
ZBT24_HUMAN / O43167 Zinc finger and BTB domain-containing protein 24; Zinc finger protein 450 from Homo sapiens (Human) (see 2 papers)
NP_055612 zinc finger and BTB domain-containing protein 24 isoform 1 from Homo sapiens
44% identity, 11% coverage
- function: May be involved in BMP2-induced transcription.
subunit: Interacts with MN1. - ZBTB24 (Zinc Finger and BTB Domain Containing 24) prevents recurrent spontaneous abortion by promoting trophoblast proliferation, differentiation and migration.
Ruan, Bioengineered 2022 - GeneRIF: ZBTB24 (Zinc Finger and BTB Domain Containing 24) prevents recurrent spontaneous abortion by promoting trophoblast proliferation, differentiation and migration.
- Loss of ZBTB24 impairs nonhomologous end-joining and class-switch recombination in patients with ICF syndrome.
Helfricht, The Journal of experimental medicine 2020 - GeneRIF: Loss of ZBTB24 impairs nonhomologous end-joining and class-switch recombination in patients with ICF syndrome.
- ZBTB24 regulates the apoptosis of human T cells via CDCA7/TRAIL-receptor axis.
Qin, Biochemical and biophysical research communications 2019 (PubMed)- GeneRIF: ZBTB24 activates the expression of CDCA7 in T cells.ZBTB24 regulates the apoptosis of T cells via CDCA7/TRAIL-R axis.
- Identification of ZBTB24 protein domains and motifs for heterochromatin localization and transcriptional activation.
Aktar, Genes to cells : devoted to molecular & cellular mechanisms 2019 (PubMed)- GeneRIF: Identification of ZBTB24 protein domains and motifs for heterochromatin localization and transcriptional activation. Domains and motifs important for the biological function of ZBTB24, which provides a basis for understanding the molecular mechanisms underlying the pathogenesis of ICF syndrome.
- Comparative methylome analysis of ICF patients identifies heterochromatin loci that require ZBTB24, CDCA7 and HELLS for their methylated state.
Velasco, Human molecular genetics 2018 (PubMed)- GeneRIF: Here, we performed a comparative analysis of perturbed DNA methylation landscapes in a cohort of ICF patients using an array-based assay to (i) evaluate the similarities and differences in methylation landscapes depending on patient genotypes as an index of a functional link between the four ICF factors, (ii) identify genomic regions that rely on DNMT3B, ZBTB24, CDCA7 or HELLS for their methylation status
- Roles of Alternative RNA Splicing of the Bif-1 Gene by SRRM4 During the Development of Treatment-induced Neuroendocrine Prostate Cancer.
Gan, EBioMedicine 2018 - GeneRIF: data indicate that SRRM4 regulates alternative RNA splicing of the Bif-1 gene that enables PCa cells resistant to apoptotic stimuli under anti-cancer therapies, and may contribute to AdPC progression into t-NEPC.
- Subtelomeric methylation distinguishes between subtypes of Immunodeficiency, Centromeric instability and Facial anomalies syndrome.
Toubiana, Human molecular genetics 2018 (PubMed)- GeneRIF: in contrast to Immunodeficiency, Centromeric instability and Facial anomalies syndrome type 1 (ICF1), the subtelomeric methylation patterns in cells of ICF2-4 patients do not differ significantly from those in normal cells, and ICF2-4 cells exhibit a normal telomeric phenotype. Also knocking down the expression of ZBTB24, CDCA7 and HELLS in normal human fibroblasts does not affect subtelomeric methylation.
- ZBTB24 is a transcriptional regulator that coordinates with DNMT3B to control DNA methylation.
Thompson, Nucleic acids research 2018 - GeneRIF: Chromatin immunoprecipitation coupled with loss-of-function approaches in model systems revealed common loci bound by ZBTB24 and DNMT3B, where they function to regulate gene body methylation. Genes coordinately regulated by ZBTB24 and DNMT3B are enriched for molecular mechanisms essential for cellular homeostasis, highlighting the importance of the ZBTB24-DNMT3B interplay in maintaining epigenetic patterns
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- Gain-of-Function MN1 Truncation Variants Cause a Recognizable Syndrome with Craniofacial and Brain Abnormalities.
Miyake, American journal of human genetics 2020 - Anterior segment alterations and comparative aqueous humor proteomics in the buphthalmic rabbit (an American Ophthalmological Society thesis).
Edward, Transactions of the American Ophthalmological Society 2011
XP_005507592 Krueppel-like factor 15 isoform X2 from Columba livia
39% identity, 18% coverage
NP_989267 zinc finger protein SNAI1 from Xenopus tropicalis
43% identity, 29% coverage
XP_005652624 transcription factor Sp1 isoform X1 from Sus scrofa
36% identity, 10% coverage
NP_001071495 transcription factor Sp1 from Bos taurus
36% identity, 10% coverage
XP_017903034 transcription factor Sp1 isoform X2 from Capra hircus
36% identity, 10% coverage
XP_009463837 zinc finger protein SNAI1 from Nipponia nippon
43% identity, 38% coverage
- Potential Involvement of Snail Members in Neuronal Survival and Astrocytic Migration during the Gecko Spinal Cord Regeneration
Shen, Frontiers in cellular neuroscience 2017 - “...Snail3 (NP_001179562); dolphin Lipotes vexillifer Snail1 (XP_007446447), Snail2 (XP_007464078), Snail3 (XP_007468498); bird Nipponia nippon Snail1 (XP_009463837), Snail2 (XP_009471359), Snail3 (XP_009475765); bird Haliaeetus leucocephalus Snail1 (XP_010567958), Snail2 (XP_010572691), Snail3 (XP_010578013); bird Serinus canaria Snail1 (XP_009091543), Snail2 (XP_009101147); green anole Anolis carolinensis Snail1 (XP_003220701), Snail2 (XP_003223554), Snail3 (XP_003228606);...”
Q9YIB7 Zinc finger protein ZIC 2-B from Xenopus laevis
40% identity, 14% coverage
SPTF3_CAEEL / Q9XW26 Specificity protein transcription factor 3 from Caenorhabditis elegans (see 3 papers)
NP_493353 Specificity protein transcription factor 3 from Caenorhabditis elegans
37% identity, 18% coverage
- function: Transcription factor (PubMed:21884786, PubMed:23851392). Binds to GC-rich DNA motifs, such as 5'-GGGCGGGG-3' (PubMed:21884786, PubMed:23851392). Involved in cell autonomous neuroblast asymmetric divisions that generate one precursor cell and one apoptotic cell, by transcriptionally activating target genes, such as cell death activator egl-1 and leucine zipper kinase pig-1, in caspase-dependent and -independent apoptotic pathways (PubMed:23851392). Plays a role in the regulation of apoptosis, cell lineage, cell differentiation, embryonic morphogenesis, vulval development, and oocyte production (PubMed:21884786, PubMed:23851392, PubMed:26434722).
disruption phenotype: RNAi-mediated knockdown causes defects in cell fate, embryonic morphogenesis, and embryonic and larval lethality (PubMed:21884786, PubMed:23851392). Defects in gastrulation; failure of endodermal E cells to internalize at the 26- to 28-cell stage (PubMed:26434722). Reduces cell cycle lengths significantly in endodermal E cells (PubMed:26434722). Significant reduction in expression of end-1 and end-3, and enhances the disruption of intestinal development in an end-3 mutant background (PubMed:26434722). Reduces number of offspring, and the production of oocytes is compromised (PubMed:21884786). Failure of cell death in pharyngeal M4 motor neuron sister (PubMed:21884786). - An Sp1 transcription factor coordinates caspase-dependent and -independent apoptotic pathways.
Hirose, Nature 2013 - GeneRIF: SPTF-3 specifies the programmed cell deaths of at least two cells-the sisters of the pharyngeal M4 motor neuron and the AQR sensory neuron-by transcriptionally activating both caspase-dependent and -independent apoptotic pathways
- A survey of well conserved families of C2H2 zinc-finger genes in Daphnia
Seetharam, BMC genomics 2010 - “...scaffold_130:263756-265967 SP2 (Q02086) DSp1 (NP_727360) SPTF2 (NP_495833) SP1 (Dappu-315784) scaffold_15:792601-795915 SP3/SPR2 (Q02447) CG5669 (NP_651232) SPTF3 (NP_493353) SP8 (Dappu-106303) scaffold_42:141432-144224 SP4/SPR1 (Q02446) SP5 (Q6BEB4) SP6/KLF14 (Q3SY56) SP7 (Q8TDD2) SP8 (Q8IXZ3) KLF KLF1 (Q13351) CG12029 (NP_647822) KLF1 (NP_497632) KLF1A (Dappu-48391) scaffold_16:1551074-1551469 KLF2 (Q9Y5W3) CG9895 (NP_611747) F53F8.1 (NP_507995) KLF1B...”
- Developmental functions for the Caenorhabditis elegans Sp protein SPTF-3.
Ulm, Mechanisms of development (PubMed)- GeneRIF: Developmental functions for the Caenorhabditis elegans Sp protein SPTF-3.
XP_069908397 transcription factor Sp1 isoform X6 from Oryctolagus cuniculus
36% identity, 10% coverage
SP1_HUMAN / P08047 Transcription factor Sp1 from Homo sapiens (Human) (see 35 papers)
NP_612482 transcription factor Sp1 isoform a from Homo sapiens
36% identity, 10% coverage
- function: Transcription factor that can activate or repress transcription in response to physiological and pathological stimuli. Binds with high affinity to GC-rich motifs and regulates the expression of a large number of genes involved in a variety of processes such as cell growth, apoptosis, differentiation and immune responses. Highly regulated by post-translational modifications (phosphorylations, sumoylation, proteolytic cleavage, glycosylation and acetylation). Binds also the PDGFR-alpha G-box promoter. May have a role in modulating the cellular response to DNA damage. Implicated in chromatin remodeling. Plays an essential role in the regulation of FE65 gene expression. In complex with ATF7IP, maintains telomerase activity in cancer cells by inducing TERT and TERC gene expression. Isoform 3 is a stronger activator of transcription than isoform 1. Positively regulates the transcription of the core clock component BMAL1 (PubMed:10391891, PubMed:11371615, PubMed:11904305, PubMed:14593115, PubMed:16377629, PubMed:16478997, PubMed:16943418, PubMed:17049555, PubMed:18171990, PubMed:18199680, PubMed:18239466, PubMed:18513490, PubMed:18619531, PubMed:19193796, PubMed:20091743, PubMed:21046154, PubMed:21798247). Plays a role in the recruitment of SMARCA4/BRG1 on the c-FOS promoter. Plays a role in protecting cells against oxidative stress following brain injury by regulating the expression of RNF112 (By similarity).
subunit: Interacts with ATF7IP, ATF7IP2, BAHD1, POGZ, HCFC1, AATF and PHC2. Interacts with HLTF; the interaction may be required for basal transcriptional activity of HLTF. Interacts (deacetylated form) with EP300; the interaction enhances gene expression. Interacts with HDAC1 and JUN. Interacts with ELF1; the interaction is inhibited by glycosylation of SP1. Interaction with NFYA; the interaction is inhibited by glycosylation of SP1. Interacts with ATF7IP and TBP. Interacts with MEIS2 isoform 4 and PBX1 isoform PBX1a. Interacts with EGR1 (PubMed:10391891, PubMed:10976766, PubMed:12021324, PubMed:12847090, PubMed:12855699, PubMed:15691849, PubMed:16478997, PubMed:19106100, PubMed:19285002, PubMed:19302979, PubMed:19666599, PubMed:20121949, PubMed:21746878, PubMed:7592727, PubMed:9466902). Interacts with SMARCA4/BRG1. Interacts with RNF112 in an oxidative stress-regulated manner (By similarity). Interacts with ZBTB7A; ZBTB7A prevents the binding to GC-rich motifs in promoters and represses the transcriptional activity of SP1 (PubMed:12004059). Interacts with DDX3X; this interaction potentiates SP1-induced CDKN1A/WAF1/CIP1 transcription (PubMed:16818630). Interacts with MSX1; the interaction may inhibit MSX1 autoinactivation (By similarity).
subunit: (Microbial infection) Interacts with varicella-zoster virus IE62 protein.
subunit: (Microbial infection) Interacts with SV40 VP2/3 proteins. Interacts with SV40 major capsid protein VP1; this interaction leads to a cooperativity between the 2 proteins in DNA binding.
subunit: (Microbial infection) Interacts with HIV-1 Vpr; the interaction is inhibited by SP1 O-glycosylation. - Predicting Which Mitophagy Proteins Are Dysregulated in Spinocerebellar Ataxia Type 3 (SCA3) Using the Auto-p2docking Pipeline.
Vieira, International journal of molecular sciences 2025 - Comparative transcriptome of normal and cancer-associated fibroblasts.
Abikar, BMC cancer 2024 - “...Q7Z2W4 protein NONHSAG099482 LINC01301 ZMAT3 Q9HA38 protein NONHSAG099482 LINC01301 ZMAT3 Q9HA38 protein NONHSAG099482 LINC01301 SP1 P08047 protein NONHSAG099482 LINC01301 IGF2BP3 O00425 protein NONHSAG099482 LINC01301 RBMX P38159 protein NONHSAG099482 LINC01301 SOX2 P48431 protein NONHSAG099482 LINC01301 U2AF1 Q01081 protein NONHSAG099482 LINC01301 ILF2 Q12905 protein NONHSAG099482 LINC01301 IGF2BP1 Q9NZI8...”
- “...Q7Z2W4 protein NONHSAG035677 LINC00882 ZMAT3 Q9HA38 protein NONHSAG035677 LINC00882 ZMAT3 Q9HA38 protein NONHSAG035677 LINC00882 SP1 P08047 protein NONHSAG035677 LINC00882 WDR4 P57081 protein NONHSAG035677 LINC00882 SRSF1 Q07955 protein NONHSAG035677 LINC00882 IGF2BP3 O00425 protein NONHSAG035677 LINC00882 RBMX P38159 protein NONHSAG035677 LINC00882 SOX2 P48431 protein NONHSAG035677 LINC00882 HNRNPM P52272...”
- Docking and molecular dynamic simulations of Mithramycin-A and Tolfenamic acid against Sp1 and survivin.
Lambring, Process biochemistry (Barking, London, England) 2024 - Employing non-targeted interactomics approach and subcellular fractionation to increase our understanding of the ghost proteome
Garcia-Del, iScience 2023 - “...organelles. Furthermore, it has been described in the chromatin 28 and cytoskeleton. 29 SP1 (UniProt: P08047) was annotated to reside in the nucleus and in the cytoplasm. Here, we observed two strong signals in the nucleus and the cytoskeleton, the latter can be explained by the...”
- Systematic proteomics profiling of lysine crotonylation of the lung at Pseudoglandular and Canalicular phases in human fetus.
Wang, Proteome science 2023 - “...protein cut-like 1 CUX1 1.581 Up Q9Y547 Intraflagellar transport protein 25 homolog HSPB11 1.533 Up P08047 Transcription factor Sp1 SP1 1.528 Up Q9UPY3 Endoribonuclease Dicer DICER1 1.527 Up P09486 SPARC SPARC 0.661 Down Q16706 Alpha-mannosidase 2 MAN2A1 0.621 Down P29466 Caspase-1 CASP1 0.613 Down P24821 Tenascin...”
- Reviewing Atrial Fibrillation Pathophysiology from a Network Medicine Perspective: The Relevance of Structural Remodeling, Inflammation, and the Immune System.
Martins, Life (Basel, Switzerland) 2023 - “...PSBG1 PSGGA ENSP00000323155 Q8N907 DAN domain family member 5 DAND5 CER2 CKTSF1B3 GREM3 SP1 ENSP00000329357 P08047 Transcription factor Sp1 SP1 TSFP1 ENSP00000337383 A0A7I2R3P8 NLR family pyrin domain containing 3 NLRP3 ENSP00000338345 P37840 Alpha-synuclein SNCA NACP PARK1 ENSP00000357726 P80511 Protein S100-A12 S100A12 ENSP00000368244 P05060 Secretogranin-1 CHGB SCG1...”
- The Dual Functions of Andrographolide in the Epstein-Barr Virus-Positive Head-and-Neck Cancer Cells: The Inhibition of Lytic Reactivation of the Epstein-Barr Virus and the Induction of Cell Death.
Heawchaiyaphum, International journal of molecular sciences 2023 - “...HDAC5 (Uniprot ID: Q9UQL6), HDAC9 (Uniprot ID: Q9UKV0), MEF2D (Uniprot ID: Q14814), SP1 (Uniprot ID: P08047), and SP3 (Uniprot ID: Q02447), were submitted to SWISS-MODEL, https://swissmodel.expasy.org/ (accessed on 24 November 2021) [ 72 ], a protein prediction software, to build the putative 3D structures. The stereochemistry...”
- iPTMnet RESTful API for Post-translational Modification Network Analysis
Gavali, Methods in molecular biology (Clifton, N.J.) 2022 - “...for readability) Column Result-1 Result-2 Interactant ID Q92540 P08047 Interactant name SMG7 SP1 Substrate ID P04637 P04637 Substrate name TP53 TP53 Association...”
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- A Specificity Protein 1 assists the Progression of the Papillary Thyroid Cell Line by Initiating NECTIN4.
Chen, Endocrine, metabolic & immune disorders drug targets 2024 (PubMed)- GeneRIF: A Specificity Protein 1 assists the Progression of the Papillary Thyroid Cell Line by Initiating NECTIN4.
- KLF6 activates Sp1-mediated prolidase transcription during TGF-β1 signaling.
Eni-Aganga, The Journal of biological chemistry 2024 - GeneRIF: KLF6 activates Sp1-mediated prolidase transcription during TGF-beta1 signaling.
- SP1-activated USP27X-AS1 promotes hepatocellular carcinoma progression via USP7-mediated AKT stabilisation.
Su, Clinical and translational medicine 2024 - GeneRIF: SP1-activated USP27X-AS1 promotes hepatocellular carcinoma progression via USP7-mediated AKT stabilisation.
- Translation regulatory long non-coding RNA 1 negatively regulates cell radiosensitivity via the miR-22-3p/SP1 axis in non-small cell lung cancer.
Zhong, The clinical respiratory journal 2024 - GeneRIF: Translation regulatory long non-coding RNA 1 negatively regulates cell radiosensitivity via the miR-22-3p/SP1 axis in non-small cell lung cancer.
- Interaction of Sp1 and Setd8 promotes vascular smooth muscle cells apoptosis by activating Mark4 in vascular calcification.
Li, Aging 2024 - GeneRIF: Interaction of Sp1 and Setd8 promotes vascular smooth muscle cells apoptosis by activating Mark4 in vascular calcification.
- Sp1 facilitates continued HSV-1 gene expression in the absence of key viral transactivators.
Sodroski, mBio 2024 - GeneRIF: Sp1 facilitates continued HSV-1 gene expression in the absence of key viral transactivators.
- RBBP7, regulated by SP1, enhances the Warburg effect to facilitate the proliferation of hepatocellular carcinoma cells via PI3K/AKT signaling.
Fang, Journal of translational medicine 2024 - GeneRIF: RBBP7, regulated by SP1, enhances the Warburg effect to facilitate the proliferation of hepatocellular carcinoma cells via PI3K/AKT signaling.
- Transcriptional regulation of SARS-CoV-2 receptor ACE2 by SP1.
Han, eLife 2024 - GeneRIF: Transcriptional regulation of SARS-CoV-2 receptor ACE2 by SP1.
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LOC101863331 transcription factor Sp3 from Aplysia californica
36% identity, 9% coverage
- Single-neuron analysis of aging-associated changes in learning reveals impairments in transcriptional plasticity
Badal, Aging cell 2024 - “...LOC101852427, LOC118477209, LOC101845787, LOC101860932, LOC101857232), transcription factor 20, MafF, Sox10, Sp3, TFIIIB (LOC101853672, LOC101851728, LOC101847270, LOC101863331, LOC101855811). Interestingly we identified several epigenetic regulation related genes such as histone acetyltransferase KAT2A isoform (LOC101856257), histonelysine Nmethyltransferase ASH1L isoform (LOC101849998), GADD45 (LOC101853028, LOC101846541), KAT8 regulatory NSL complex subunit 1...”
1meyF Crystal structure of a designed zinc finger protein bound to DNA (see paper)
43% identity, 92% coverage
- Ligands: dna; zinc ion (1meyF)
NP_001029710 zinc finger protein SNAI2 from Bos taurus
43% identity, 28% coverage
- Potential Involvement of Snail Members in Neuronal Survival and Astrocytic Migration during the Gecko Spinal Cord Regeneration
Shen, Frontiers in cellular neuroscience 2017 - “...mouse Mus musculus Snail1 (NP_035557), Snail2 (NP_035545), Snail3 (NP_038942); cattle Bos taurus Snail1 (NP_001106179), Snail2 (NP_001029710), Snail3 (NP_001179562); dolphin Lipotes vexillifer Snail1 (XP_007446447), Snail2 (XP_007464078), Snail3 (XP_007468498); bird Nipponia nippon Snail1 (XP_009463837), Snail2 (XP_009471359), Snail3 (XP_009475765); bird Haliaeetus leucocephalus Snail1 (XP_010567958), Snail2 (XP_010572691), Snail3 (XP_010578013); bird...”
ZIC2A_XENLA / Q91689 Zinc finger protein ZIC 2-A; Zinc finger DNA-binding protein fZic; Zinc finger protein ZIC 2; XlZic2; xZic2; Zinc finger protein of the cerebellum 2-A from Xenopus laevis (African clawed frog) (see 5 papers)
40% identity, 14% coverage
- function: Transcriptional repressor that inhibits neurogenesis and induces neural and neural crest differentiation. Regulates anteroposterior patterning in early development by inhibiting expression of the nodal genes through the inhibition of vegt. Required for gastrulation movements and for proper anterior neural and axial development. May also act as a transcriptional activator. May bind to the minimal GLI-consensus sequence 5'-TGGGTGGTC-3'.
XP_001358829 transcription factor Sp4 from Drosophila pseudoobscura
36% identity, 8% coverage
- A clustered set of three Sp-family genes is ancestral in the Metazoa: evidence from sequence analysis, protein domain structure, developmental expression patterns and chromosomal location
Schaeper, BMC evolutionary biology 2010 - “...NP_651232 ], Dm_ Btd [GenBank: NP_511100 ], Dm_ D-Sp1 [GenBank: NP_572579 ], Dps_ GA19045 [GenBank: XP_001358829 ], Dps_ GA22354 [GenBank: XP_002134535 ], Dps _GA12282 [GenBank: XP_001354397 ], Ag _Sp1-4 [GenBank: NZ_AAAB02008898 ], Ag _Sp5/Btd [GenBank: NZ_AAAB02008847 ], Ag Sp6-9 [GenBank: NZ_AAAB01008847 ]; Nav _Sp1-4 [GenBank: XP_001599101...”
NP_001119814 zinc finger protein SNAI2 from Ovis aries
43% identity, 28% coverage
NP_038700 transcription factor Sp1 from Mus musculus
36% identity, 10% coverage
SP1_MOUSE / O89090 Transcription factor Sp1; Specificity protein 1 from Mus musculus (Mouse) (see 5 papers)
36% identity, 10% coverage
- function: Transcription factor that can activate or repress transcription in response to physiological and pathological stimuli. Binds with high affinity to GC-rich motifs and regulates the expression of a large number of genes involved in a variety of processes such as cell growth, apoptosis, differentiation and immune responses. Highly regulated by post-translational modifications (phosphorylations, sumoylation, proteolytic cleavage, glycosylation and acetylation). Binds also the PDGFR-alpha G-box promoter. May have a role in modulating the cellular response to DNA damage. Implicated in chromatin remodeling. Plays a role in the recruitment of SMARCA4/BRG1 on the c- FOS promoter Plays an essential role in the regulation of FE65 gene expression (By similarity). Positively regulates the transcription of the core clock component BMAL1 (PubMed:24030830). Plays a role in protecting cells against oxidative stress following brain injury by regulating the expression of RNF112 (PubMed:27918959).
subunit: Interacts with ATF7IP, ATF7IP2, BAHD1, POGZ, HCFC1, AATF and PHC2. Interacts with SV40 VP2/3 proteins. Interacts with SV40 major capsid protein VP1; this interaction leads to a cooperativity between the 2 proteins in DNA binding. Interacts with HLTF; the interaction may be required for basal transcriptional activity of HLTF. Interacts (deacetylated form) with EP300; the interaction enhances gene expression. Interacts with HDAC1 and JUN. Interacts with ELF1; the interaction is inhibited by glycosylation of SP1. Interaction with NFYA; the interaction is inhibited by glycosylation of SP1. Interacts with SMARCA4/BRG1. Interacts with ATF7IP and TBP. Interacts with MEIS2 isoform 4 and PBX1 isoform PBX1a. Interacts with EGR1 (By similarity). Interacts with RNF112 in an oxidative stress-regulated manner (PubMed:27918959). Interacts with ZBTB7A; ZBTB7A prevents the binding to GC-rich motifs in promoters and represses the transcriptional activity of SP1 (By similarity). Interacts with DDX3X; this interaction potentiates SP1-induced CDKN1A/WAF1/CIP1 transcription (By similarity). Interacts with MSX1; the interaction may inhibit MSX1 autoinactivation (PubMed:10215616). Interacts with MSX3 (PubMed:10215616).
subunit: (Microbial infection) Interacts with murine minute virus NS1; this interaction allows high levels of viral P38 promoter transactivation by NS1. - Effect of Semaglutide and Empagliflozin on Pulmonary Structure and Proteomics in Obese Mice.
Yang, Diabetes, metabolic syndrome and obesity : targets and therapy 2024 - “...beta subcomplex subunit 6 Ndufb6 Down Down Q8VD57 Vesicle transport protein SFT2B Sft2d2 Down Down O89090 Transcription factor Sp1 Sp1 Down Down Q9ESD7 Dysferlin Dysf Down Down Q6IMF0 Keratin, type II cuticular 87 Krt87 Down Down O54692 Centromere/kinetochore protein zw10 homolog Zw10 Down Down Q69ZR9 Protein...”
- KRAS, YWHAE, SP1 and MSRA as biomarkers in endometrial cancer
Yang, Translational cancer research 2021 - “...1.39616613 0.01765495 Q5U4C9 Dyrk2 112.766667 87.2333333 1.29270157 0.02412443 P70224 Gimap1 110 90 1.22222222 0.0038861 Down-regulated O89090 SP1 89.6 110.433333 0.81134923 0.04827976 Q6PDM1 Msl1 88.6333333 111.366667 0.7958695 0.02366069 Q3UIL6 Plekha7 85.8666667 114.133333 0.75233645 0.00498638 Q9D0U1 Dtwd2 85.5666667 114.466667 0.74752475 0.00630704 P32883 KRAS 78.7 121.3 0.64880462 0.00986105 Q9D6Y7...”
- A cell model for conditional profiling of androgen-receptor-interacting proteins.
Mooslehner, International journal of endocrinology 2012 - “...(6) E9Q4N7 GATA3 coA 55 (1) P23772 SRC 57 (1) Q2M4I4 SP1 coA 81 (3) O89090 SMARCC1 CoA 1112/60 (5) Q3UNN4 TGFBI1 coA 32 (1) Q62219 SMARCD1 CoA 39 (1) Q61466 TRIM24 coA 165 (4) Q64127 NPM1 CoA 438 (6) Q5SQB0 FKBP5 coA 29 (1) Q64378...”
SP1_RAT / Q01714 Transcription factor Sp1 from Rattus norvegicus (Rat) (see 2 papers)
NP_036787 transcription factor Sp1 from Rattus norvegicus
36% identity, 10% coverage
- function: Transcription factor that can activate or repress transcription in response to physiological and pathological stimuli. Binds with high affinity to GC-rich motifs and regulates the expression of a large number of genes involved in a variety of processes such as cell growth, apoptosis, differentiation and immune responses. Highly regulated by post-translational modifications (phosphorylations, sumoylation, proteolytic cleavage, glycosylation and acetylation). Binds also the PDGFR-alpha G-box promoter. May have a role in modulating the cellular response to DNA damage. Implicated in chromatin remodeling. Plays an essential role in the regulation of FE65 gene expression. Positively regulates the transcription of the core clock component BMAL1 (By similarity). Plays a role in the recruitment of SMARCA4/BRG1 on the c-FOS promoter (PubMed:19081374). Plays a role in protecting cells against oxidative stress following brain injury by regulating the expression of RNF112 (By similarity).
subunit: Interacts with ATF7IP, ATF7IP2, BAHD1, POGZ, HCFC1, AATF and PHC2. Interacts with SV40 VP2/3 proteins. Interacts with SV40 major capsid protein VP1; this interaction leads to a cooperativity between the 2 proteins in DNA binding. Interacts with HLTF; the interaction may be required for basal transcriptional activity of HLTF. Interacts (deacetylated form) with EP300; the interaction enhances gene expression. Interacts with HDAC1 and JUN. Interacts with ELF1; the interaction is inhibited by glycosylation of SP1. Interaction with NFYA; the interaction is inhibited by glycosylation of SP1 (By similarity). Interacts with SMARCA4/BRG1 (PubMed:19081374). Interacts with ATF7IP and TBP. Interacts with MEIS2 and PBX1. Interacts with EGR1. Interacts with RNF112 in an oxidative stress-regulated manner (By similarity). Interacts with ZBTB7A; ZBTB7A prevents the binding to GC- rich motifs in promoters and represses the transcriptional activity of SP1 (By similarity). Interacts with DDX3X; this interaction potentiates SP1-induced CDKN1A/WAF1/CIP1 transcription (By similarity). Interacts with MSX1; the interaction may inhibit MSX1 autoinactivation (By similarity). Interacts with MSX3 (By similarity). - SP1-stimulated miR-208a-5p aggravates sepsis-induced myocardial injury via targeting XIAP.
Xu, Experimental cell research 2024 (PubMed)- GeneRIF: SP1-stimulated miR-208a-5p aggravates sepsis-induced myocardial injury via targeting XIAP.
- Interaction of Sp1 and Setd8 promotes vascular smooth muscle cells apoptosis by activating Mark4 in vascular calcification.
Li, Aging 2024 - GeneRIF: Interaction of Sp1 and Setd8 promotes vascular smooth muscle cells apoptosis by activating Mark4 in vascular calcification.
- MicroRNA-124-3p targets Sp1 transcription factor to regulate glioma progression in rats.
Vaghf, Gene 2024 (PubMed)- GeneRIF: MicroRNA-124-3p targets Sp1 transcription factor to regulate glioma progression in rats.
- Eukaryotic translation initiation factor 6-mediated ribosome biogenesis promotes synovial aggression and inflammation by increasing the translation of SP1 in rheumatoid arthritis.
Shen, International immunopharmacology 2024 (PubMed)- GeneRIF: Eukaryotic translation initiation factor 6-mediated ribosome biogenesis promotes synovial aggression and inflammation by increasing the translation of SP1 in rheumatoid arthritis.
- Regulation of peroxiredoxin-3 gene expression under basal and hyperglycemic conditions: Key roles for transcription factors Sp1, CREB and NF-κB.
Arkat, Biochimica et biophysica acta. Molecular basis of disease 2023 (PubMed)- GeneRIF: Regulation of peroxiredoxin-3 gene expression under basal and hyperglycemic conditions: Key roles for transcription factors Sp1, CREB and NF-kappaB.
- Sp1 mediated the inhibitory effect of glutamate on pulmonary surfactant synthesis.
Li, PloS one 2023 - GeneRIF: Sp1 mediated the inhibitory effect of glutamate on pulmonary surfactant synthesis.
- Silencing of specificity protein 1 protects H9c2 cells against lipopolysaccharide-induced injury via binding to the promoter of chemokine CXC receptor 4 and suppressing NF-κB signaling.
Zhu, Bioengineered 2022 - GeneRIF: Silencing of specificity protein 1 protects H9c2 cells against lipopolysaccharide-induced injury via binding to the promoter of chemokine CXC receptor 4 and suppressing NF-kappaB signaling.
- Sp1 Inhibits PGC-1α via HDAC2-Catalyzed Histone Deacetylation in Chronic Constriction Injury-Induced Neuropathic Pain.
Miao, ACS chemical neuroscience 2022 (PubMed)- GeneRIF: Sp1 Inhibits PGC-1alpha via HDAC2-Catalyzed Histone Deacetylation in Chronic Constriction Injury-Induced Neuropathic Pain.
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NP_001083799 zinc finger protein ZIC 1 from Xenopus laevis
42% identity, 16% coverage
- Anterior patterning genes induced by Zic1 are sensitive to retinoic acid and its metabolite, 4-oxo-RA.
Dubey, Developmental dynamics : an official publication of the American Association of Anatomists 2022 - GeneRIF: Anterior patterning genes induced by Zic1 are sensitive to retinoic acid and its metabolite, 4-oxo-RA.
- PR domaincontaining protein 12 (prdm12) is a downstream target of the transcription factor zic1 during cellular differentiation in the central nervous system: PR domain containing protein is the right form.
Rahman, International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience 2020 (PubMed)- GeneRIF: PR domaincontaining protein 12 (prdm12) is a downstream target of the transcription factor zic1 during cellular differentiation in the central nervous system: PR domain containing protein is the right form.
- The cytoskeletal protein Zyxin interacts with the zinc-finger transcription factor Zic1 and plays the role of a scaffold for Gli1 and Zic1 interactions during early development of Xenopus laevis.
Martynova, Biochemical and biophysical research communications 2018 (PubMed)- GeneRIF: Zyxin has a scaffolding role in Gli1 and Zic1 interactions and in the regulation of Shh signaling cascade
- Znf703, a novel target of Pax3 and Zic1, regulates hindbrain and neural crest development in Xenopus.
Hong, Genesis (New York, N.Y. : 2000) 2017 - GeneRIF: snai2 and sox10 expression was severely impaired upon manipulation of Znf703 expression levels in the embryo suggesting that Znf703 participates in neural crest formation downstream of Pax3 and Zic1 in Xenopus
- Zic1 controls placode progenitor formation non-cell autonomously by regulating retinoic acid production and transport.
Jaurena, Nature communications 2015 - GeneRIF: Zic1, expressed at the anterior neural plate, is necessary and sufficient to promote placode fate.
- Pax3 and Zic1 trigger the early neural crest gene regulatory network by the direct activation of multiple key neural crest specifiers.
Plouhinec, Developmental biology 2014 - GeneRIF: Pax3 and Zic1 trigger the early neural crest gene regulatory network by the direct activation of multiple key neural crest specifiers.
- Pax3 and Zic1 drive induction and differentiation of multipotent, migratory, and functional neural crest in Xenopus embryos.
Milet, Proceedings of the National Academy of Sciences of the United States of America 2013 - GeneRIF: Pax3 and Zic1 drive induction and differentiation of multipotent, migratory, and functional neural crest in Xenopus embryos.
- Xenopus Meis3 protein lies at a nexus downstream to Zic1 and Pax3 proteins, regulating multiple cell-fates during early nervous system development.
Gutkovich, Developmental biology 2010 (PubMed)- GeneRIF: XMeis3 protein knock down also causes a loss of primary neuron and neural crest cell lineages, without altering expression of Zic, Sox or Pax3 genes.
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ZIC1_XENLA / O73689 Zinc finger protein ZIC 1; XZic1; XlZic1; ODD-paired-like; Xopl; ZIC-related protein 1; ZIC-r1; Zinc finger protein of the cerebellum 1 from Xenopus laevis (African clawed frog) (see 10 papers)
42% identity, 16% coverage
- function: Transcriptional activator that induces expression of multiple genes including pax3, en2, snai2/slug, feb and a subset of wnt genes. Has multiple key roles in the regulation of neural induction and neurogenesis: acts as a neural competence factor, sensitizing the presumptive neuroectoderm to respond to subsequent neuralizing signals. Promotes both preplacodal cell fates and neural crest cell fates, two of the cell populations that arise from the neural plate border. Cooperates with pax3 in concert with wnt signaling to determine neural crest fate. Synergizes with the bmp-inhibitor noggin/nog and acts through the wnt pathway to induce expression of en2. May bind to the minimal GLI-consensus sequence 5'-TGGGTGGTC-3'.
Q86WZ6 Zinc finger protein 227 from Homo sapiens
45% identity, 10% coverage
NP_001081193 zinc finger protein ZIC 2-A from Xenopus laevis
40% identity, 14% coverage
XP_007464078 zinc finger protein SNAI2 from Lipotes vexillifer
43% identity, 28% coverage
- Potential Involvement of Snail Members in Neuronal Survival and Astrocytic Migration during the Gecko Spinal Cord Regeneration
Shen, Frontiers in cellular neuroscience 2017 - “...cattle Bos taurus Snail1 (NP_001106179), Snail2 (NP_001029710), Snail3 (NP_001179562); dolphin Lipotes vexillifer Snail1 (XP_007446447), Snail2 (XP_007464078), Snail3 (XP_007468498); bird Nipponia nippon Snail1 (XP_009463837), Snail2 (XP_009471359), Snail3 (XP_009475765); bird Haliaeetus leucocephalus Snail1 (XP_010567958), Snail2 (XP_010572691), Snail3 (XP_010578013); bird Serinus canaria Snail1 (XP_009091543), Snail2 (XP_009101147); green anole Anolis...”
NP_001159857 transcription factor Sp4 isoform 2 from Mus musculus
36% identity, 10% coverage
- Transcription factor Sp4 is required for hyperalgesic state persistence.
Sheehan, PloS one 2019 - GeneRIF: Although our studies initially focused on the relationship between Sp4, TRPV1 and thermal hyperalgesia, our results more broadly suggest that a larger Sp4-dependent gene network or nociceptive transcriptome exists inclusive of TRPV1, TRPA1 and TRPM8.
- Krüppel-like factor 5 (Klf5) regulates expression of mouse T1R1 amino acid receptor gene (Tas1r1) in C2C12 myoblast cells.
Hirata, Biomedical research (Tokyo, Japan) 2019 (PubMed)- GeneRIF: RNAi-mediated depletion of Sp4 and Klf5 decreased Tas1r1 expression, while overexpression of Klf5, but not Sp4, significantly increased Tas1r1 expression in the myoblast cells.
- Ketamine independently modulated power and phase-coupling of theta oscillations in Sp4 hypomorphic mice.
Wang, PloS one 2018 - GeneRIF: Sp4 hypomorphic mice had markedly elevated theta power localized frontally and parietally, a more pronounced theta phase progression along the neuraxis, and a stronger frontal-parietal theta coupling. Acute subanesthetic ketamine did not affect theta power in wildtype animals but significantly reduced it in Sp4 hypomorphic mice, nearly completely neutralizing their excessive frontal/parietal theta power.
- GlyT-1 Inhibition Attenuates Attentional But Not Learning or Motivational Deficits of the Sp4 Hypomorphic Mouse Model Relevant to Psychiatric Disorders.
Young, Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2015 - GeneRIF: The transcription factor Specificity Protein 4 (SP4) is important for neurodevelopment and is genetically associated with both schizophrenia and bipolar disorder.
- Restoration of Sp4 in Forebrain GABAergic Neurons Rescues Hypersensitivity to Ketamine in Sp4 Hypomorphic Mice.
Higa, The international journal of neuropsychopharmacology 2015 - GeneRIF: Results suggest that the Sp4 gene in forebrain GABAergic neurons regulates ketamine-induced hyperlocomotion
- Prolonged Ketamine Effects in Sp4 Hypomorphic Mice: Mimicking Phenotypes of Schizophrenia.
Ji, PloS one 2013 - GeneRIF: elucidation of the Sp4 molecular pathway in Sp4 hypomorphic mice may provide novel insights to our understanding of abnormal NMDAR signaling in schizophrenia
- Specificity protein 4 functionally regulates the transcription of NMDA receptor subunits GluN1, GluN2A, and GluN2B.
Priya, Biochimica et biophysica acta 2013 - GeneRIF: Sp4 functionally regulated GluN1, GluN2A, and GluN2B, but not GluN2C.
- Neuron-specific specificity protein 4 bigenomically regulates the transcription of all mitochondria- and nucleus-encoded cytochrome c oxidase subunit genes in neurons.
Johar, Journal of neurochemistry 2013 - GeneRIF: neuron-specific Sp4 regulates the expression of all 13 subunits of mitochondrial cytochrome c oxidase(COX) enzyme in primary neurons. Sp4 also regulates mitochondrial transcription factors (TFAM, TFB1M, and TFB2M) and a COX assembly protein SURF-1.
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NP_036893 transcription factor Sp4 from Rattus norvegicus
36% identity, 10% coverage
- Specificity protein 4 (Sp4) transcriptionally regulates inhibitory GABAergic receptors in neurons.
Nair, Biochimica et biophysica acta 2016 - GeneRIF: Sp4 is in a position to transcriptionally regulate the balance between excitatory and inhibitory neurochemical expressions in neurons.
- Restoration of Sp4 in Forebrain GABAergic Neurons Rescues Hypersensitivity to Ketamine in Sp4 Hypomorphic Mice.
Higa, The international journal of neuropsychopharmacology 2015 - GeneRIF: Results suggest that the Sp4 gene in forebrain GABAergic neurons regulates ketamine-induced hyperlocomotion
- Phosphorylation of the transcription factor Sp4 is reduced by NMDA receptor signaling.
Saia, Journal of neurochemistry 2014 - GeneRIF: Sp4 is regulated by NMDA-receptor-dependent activation of a protein phosphatase 1/2A signaling pathway. Reuglated control of SP4 activity is an important mechanism governing the developmental patterning of dendrites.
- Store-operated calcium entry promotes the degradation of the transcription factor Sp4 in resting neurons.
Lalonde, Science signaling 2014 - GeneRIF: Store-operated calcium entry promotes the degradation of the transcription factor Sp4 in resting neurons.
- Transcription factors Sp1 and Sp4 regulate TRPV1 gene expression in rat sensory neurons.
Chu, Molecular pain 2011 - GeneRIF: Sp1 and Sp4 are bound to the candidate GC-box site region within the endogenous TRPV1 P2-promoter.
- Sp4-dependent repression of neurotrophin-3 limits dendritic branching.
Ramos, Molecular and cellular neurosciences 2009 - GeneRIF: Data demonstrate that, during cerebellar granule neuron development, Sp4-dependent repression of neurotrophin-3 is required to limit dendritic branching and thereby promote acquisition of the mature dendritic pattern.
- Transcription factor Sp4 regulates dendritic patterning during cerebellar maturation.
Ramos, Proceedings of the National Academy of Sciences of the United States of America 2007 - GeneRIF: Transcription factor Sp4 regulates dendritic patterning during cerebellar maturation.
- Transcriptional regulation of P450scc gene expression in the embryonic rodent nervous system.
Hammer, Endocrinology 2004 (PubMed)- GeneRIF: Sp1, Sp2 and Sp4 transcription factors play a role in activating cholesterol desmolase gene transcription in the nervous system, and Ku antigen may further augment this activation
NP_033265 transcription factor Sp4 isoform 1 from Mus musculus
36% identity, 10% coverage
- A clustered set of three Sp-family genes is ancestral in the Metazoa: evidence from sequence analysis, protein domain structure, developmental expression patterns and chromosomal location
Schaeper, BMC evolutionary biology 2010 - “...NP_038700 ], Mm _Sp2 [GenBank: NP_084496 ], Mm _Sp3 [GenBank: NP_035580 ], Mm _Sp4 [GenBank: NP_033265 ], Mm _Sp5 [GenBank: NP_071880 ], Mm _Sp6 [GenBank: NP_112460 ], Mm _Sp7 [GenBank: NP_569725 ], Mm _Sp8 [GenBank: NP_796056 ], Mm _Sp9 [GenBank: NP_001005343 ], Dr _Sp1 [GenBank: NP_997827...”
- A conserved function of the zinc finger transcription factor Sp8/9 in allometric appendage growth in the milkweed bug Oncopeltus fasciatus
Schaeper, Development genes and evolution 2009 - “...Dm_btd NP_511100, D-Sp1 NP_572579, Tc_btd NP_001107792, Tc_Sp8 NP_001034509, Mm_Sp1 NP_038700, Mm_Sp2 NP_084496, Mm_Sp3 NP_035580, Mm_Sp4 NP_033265, Mm_Sp5 NP_071880, Mm_Sp6 NP_112460, Mm_Sp7 NP_569725, Mm_Sp8 NP_796056, Mm_Sp9 NM_001005343. Species abbreviations: Mm Mus musculus , Tc Tribolium castaneum , Of Oncopeltus fasciatus , Dm Drosophila melanogaster In order to...”
NP_001080430 Kruppel-like factor 2 S homeolog from Xenopus laevis
46% identity, 19% coverage
SNAI3_MOUSE / Q9QY31 Zinc finger protein SNAI3; Protein snail homolog 3; Snail-related gene from muscle cells; Zinc finger protein 293 from Mus musculus (Mouse) (see paper)
NP_038942 zinc finger protein SNAI3 from Mus musculus
43% identity, 26% coverage
- function: Seems to inhibit myoblast differentiation. Transcriptional repressor of E-box-dependent transactivation of downstream myogenic bHLHs genes. Binds preferentially to the canonical E-box sequences 5'- CAGGTG-3' and 5'-CACCTG-3'.
- Potential Involvement of Snail Members in Neuronal Survival and Astrocytic Migration during the Gecko Spinal Cord Regeneration
Shen, Frontiers in cellular neuroscience 2017 - “...sapiens Snail1 (NP_005976), Snail2 (NP_003059), Snail3 (NP_840101); mouse Mus musculus Snail1 (NP_035557), Snail2 (NP_035545), Snail3 (NP_038942); cattle Bos taurus Snail1 (NP_001106179), Snail2 (NP_001029710), Snail3 (NP_001179562); dolphin Lipotes vexillifer Snail1 (XP_007446447), Snail2 (XP_007464078), Snail3 (XP_007468498); bird Nipponia nippon Snail1 (XP_009463837), Snail2 (XP_009471359), Snail3 (XP_009475765); bird Haliaeetus leucocephalus...”
NP_956418 transcription factor Sp4 from Danio rerio
36% identity, 11% coverage
- A clustered set of three Sp-family genes is ancestral in the Metazoa: evidence from sequence analysis, protein domain structure, developmental expression patterns and chromosomal location
Schaeper, BMC evolutionary biology 2010 - “...NP_001093452 ], Dr _Sp3 [GenBank: NP_001082967 ], Dr _Sp3-like [GenBank: XP_691096 ], Dr _Sp4 [GenBank: NP_956418 ], Dr _Sp5 [GenBank: NP_851304 ], Dr _Sp5-like [GenBank: NP_919352 ], Dr _Similar_to_Sp5 [GenBank: XP_001335730 ], Dr _Sp6 [GenBank: NP_991195 ], Dr _Sp7 [GenBank: NP_998028 ], Dr _Sp8 [GenBank: NP_998406...”
NP_001287005 pleiohomeotic like, isoform B from Drosophila melanogaster
NP_648317 pleiohomeotic like, isoform A from Drosophila melanogaster
38% identity, 11% coverage
SP4_HUMAN / Q02446 Transcription factor Sp4; SPR-1 from Homo sapiens (Human) (see paper)
NP_003103 transcription factor Sp4 isoform 1 from Homo sapiens
36% identity, 9% coverage
- function: Binds to GT and GC boxes promoters elements. Probable transcriptional activator
- SP4 Facilitates Esophageal Squamous Cell Carcinoma Progression by Activating PHF14 Transcription and Wnt/Β-Catenin Signaling.
Wei, Molecular cancer research : MCR 2024 - GeneRIF: SP4 Facilitates Esophageal Squamous Cell Carcinoma Progression by Activating PHF14 Transcription and Wnt/Beta-Catenin Signaling.
- Over-representation of potential SP4 target genes within schizophrenia-risk genes.
Zhou, Molecular psychiatry 2022 - GeneRIF: Over-representation of potential SP4 target genes within schizophrenia-risk genes.
- The genetic polymorphisms in the SP4 gene and the risk of gastric cancer.
Cui, Future oncology (London, England) 2022 (PubMed)- GeneRIF: The genetic polymorphisms in the SP4 gene and the risk of gastric cancer.
- Common and rare variants within SP4 exert distinct molecular mechanisms contributing to the risk of schizophrenia.
Zhang, Psychiatry research 2022 (PubMed)- GeneRIF: Common and rare variants within SP4 exert distinct molecular mechanisms contributing to the risk of schizophrenia.
- Sp4 Regulates PTTG1IP Gene Transcription and Expression.
Dai, DNA and cell biology 2022 (PubMed)- GeneRIF: Sp4 Regulates PTTG1IP Gene Transcription and Expression.
- The FOXP4-AS1/miR-3130-3p/SP4 feedback loop is associated with prostate cancer.
Gu, Cellular and molecular biology (Noisy-le-Grand, France) 2022 (PubMed)- GeneRIF: The FOXP4-AS1/miR-3130-3p/SP4 feedback loop is associated with prostate cancer.
- GWAS Identifies New Loci for Painful Temporomandibular Disorder: Hispanic Community Health Study/Study of Latinos.
Sanders, Journal of dental research 2017 - GeneRIF: IN TMD patients, a novel locus at genome-wide level of significance (rs73460075, OR = 0.56, P = 3.8 x 10(-8)) in the intron of the dystrophin gene DMD (X chromosome), and a suggestive locus on chromosome 7 (rs73271865, P = 2.9 x 10(-7)) upstream of the Sp4 Transcription Factor ( SP4) gene were identified in the discovery cohort, but neither of these was replicated.
- Role played by the SP4 gene in schizophrenia and major depressive disorder in the Han Chinese population.
Chen, The British journal of psychiatry : the journal of mental science 2016 (PubMed)- GeneRIF: Common risk factors in the SP4 gene are associated with schizophrenia, although not with MDD, in the Han Chinese population.
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- SP and KLF Transcription Factors in Digestive Physiology and Diseases.
Kim, Gastroenterology 2017 - “...figure are listed per UniProtKB database as follows: SP1 (P08047), SP2 (Q02086), SP3 (Q02447), SP4 (Q02446), SP5 (Q6BEB4), SP6 (Q3SY56), SP7 (Q87DD2), SP8 (Q8IXZ3), SP9 (P0CG40), KLF1 (Q13351), KLF2 (Q9Y5W3), KLF3 (P57682), KLF4 (Q43474), KLF5 (Q13887), KLF6 (Q99612), KLF7 (O75840), KLF8 (O95600), KLF9 (Q13886), KLF10 (Q13118),...”
- Krüppel-like factors in cancer progression: three fingers on the steering wheel.
Limame, Oncotarget 2014 - “...NM_003110 Q02086 613 64.9 SP3 SPR-2 AY070137 Q02447 781 81.9 SP4 SPR-1,HF1B, MGC130008, MGC130009 NM_003112 Q02446 784 82 SP5 AB096175 Q6BEB4 398 42 SP7 OSX BC113613 Q8TDD2 431 45 SP8 BC038669 Q8IXZ3 490 48.7 SP9 ZNF990 NM_001145250 P0CG40 484 48.9 KLF1 E-KLF JX877554 Q13351 362 38.2...”
- Prioritizing disease candidate proteins in cardiomyopathy-specific protein-protein interaction networks based on "guilt by association" analysis.
Li, PloS one 2013 - “...P45378 13 12691030.660 TNNT1 P13805 14 10598443.490 GJA5 P36382 15 9497687.715 cardiac arrhythmias [56] SP4 Q02446 16 7947705.183 MYL4 P12829 17 7586555.815 TPM3 P06753 18 7337310.387 TMOD1 P28289 19 7014582.495 DCM [46] MYOT Q9UBF9 20 6610783.862 TPM4 P67936 21 6600584.576 MYH3 P11055 22 6368705.641 MYBPC1 Q00872...”
- A survey of well conserved families of C2H2 zinc-finger genes in Daphnia
Seetharam, BMC genomics 2010 - “...SPTF2 (NP_495833) SP1 (Dappu-315784) scaffold_15:792601-795915 SP3/SPR2 (Q02447) CG5669 (NP_651232) SPTF3 (NP_493353) SP8 (Dappu-106303) scaffold_42:141432-144224 SP4/SPR1 (Q02446) SP5 (Q6BEB4) SP6/KLF14 (Q3SY56) SP7 (Q8TDD2) SP8 (Q8IXZ3) KLF KLF1 (Q13351) CG12029 (NP_647822) KLF1 (NP_497632) KLF1A (Dappu-48391) scaffold_16:1551074-1551469 KLF2 (Q9Y5W3) CG9895 (NP_611747) F53F8.1 (NP_507995) KLF1B (Dappu-51551) scaffold_26:196741-197325 KLF3 (P57682) CG3065...”
- An insight into the phylogenetic history of HOX linked gene families in vertebrates
Abbasi, BMC evolutionary biology 2007 - “...P08047 RNA polymerase II transcription factor activity. SP2 17q21.32 Q02086 SP3 2q31 Q02447 SP4 7p15 Q02446 SP8 7p21.2 Q8IXZ3 Zinc finger protein, subfamily 1A ZNFN1A1 7p13-p11.1 Q13422 DNA-dependent regulation of transcription, Specification and the maturation of the lymphocyte. ZNFN1A2 2qter Q9UKS7 ZNFN1A3 17q21 Q9UKT9 ZNFN1A4 12q13...”
- Trinucleotide repeats and long homopeptides in genes and proteins associated with nervous system disease and development
Karlin, Proceedings of the National Academy of Sciences of the United States of America 1996 - “...0 Gs, S7, Q6, G5, Ss, P7 0, 0, 0 SP4 Transcription Factor (Q02446) 784 Es, A6, S9 2 0, 1, 1 0, n/a Heterogeneous Nuclear Ribo-NP U (Q00839) 806 ++, ++ 0, 1, 0 0...”
NP_001300628 snail family zinc finger 1a from Danio rerio
43% identity, 29% coverage
- Bacterial induction of Snail1 contributes to blood-brain barrier disruption.
Kim, The Journal of clinical investigation 2015 - GeneRIF: data support a Snail1-dependent mechanism of BBB disruption and penetration by meningeal pathogens.
- NF-kappaB and Snail1a coordinate the cell cycle with gastrulation.
Liu, The Journal of cell biology 2009 - GeneRIF: NF-kappaB and Snail1a coordinate the cell cycle with gastrulation.
- Snail1a and Snail1b cooperate in the anterior migration of the axial mesendoderm in the zebrafish embryo.
Blanco, Development (Cambridge, England) 2007 (PubMed)- GeneRIF: Snail genes not only act as inducers of epithelial-to-mesenchymal transition, but also as more general regulators of cell adhesion and movement.
- The zebrafish bcl-2 homologue Nrz controls development during somitogenesis and gastrulation via apoptosis-dependent and -independent mechanisms.
Arnaud, Cell death and differentiation 2006 (PubMed)- GeneRIF: data suggest that Nrz, in addition to its effect on apoptosis, contributes to cell movements during gastrulation by negatively regulating the expression of Snail-1, a transcription factor that controls cell adhesion
- Snail3 orthologues in vertebrates: divergent members of the Snail zinc-finger gene family.
Manzanares, Development genes and evolution 2004 (PubMed)- GeneRIF: Snail genes lie in regions of extensive paralogy, revealing their common origin through segmental or chromosomal duplication
NP_001001950 zinc finger protein ZIC 3 from Danio rerio
40% identity, 16% coverage
NP_001034723 WT1 transcription factor b from Danio rerio
42% identity, 19% coverage
- Wilms Tumor 1b Expression Defines a Pro-regenerative Macrophage Subtype and Is Required for Organ Regeneration in the Zebrafish.
Sanz-Morejón, Cell reports 2019 - GeneRIF: Wilms Tumor 1b Expression Defines a Pro-regenerative Macrophage Subtype and Is Required for Organ Regeneration in the Zebrafish.
- Wilms Tumor 1b defines a wound-specific sheath cell subpopulation associated with notochord repair.
Lopez-Baez, eLife 2018 - GeneRIF: Here, the authors identify an unanticipated wound-specific notochord sheath cell subpopulation that expresses Wilms Tumor (WT) 1b following injury in zebrafish. They show that localized damage leads to Wt1b expression in sheath cells, and that wt1b(+)cells migrate into the wound to form a stopper-like structure, likely to maintain structural integrity.
- Function and Regulation of the Wilms' Tumor Suppressor 1 (WT1) Gene in Fish.
Perner, Methods in molecular biology (Clifton, N.J.) 2016 (PubMed)- GeneRIF: Study summarizes the different roles of WT1b gene in the embryonic zebrafish kidney and the adult kidney as well. [review]
- Sex determination in the Squalius alburnoides complex: an initial characterization of sex cascade elements in the context of a hybrid polyploid genome
Pala, PloS one 2009 - “...of the S. pyrenaicus (PP-WT1) wt1 ortholog was aligned with D. rerio (Dre-a-WT1, NP_571121; Dre-b-WT1, NP_001034723), O. mykiss (Omy-a-WT1, AAK52719; Omy-b-WT1, AAK52721), A. japonica (Aja-WT1, BAA90558) and O. latipes (Ola-WT1, BAC10628). Alignments were also performed for the deduced amino acid sequences of the two remaining genes....”
- The Wilms tumor genes wt1a and wt1b control different steps during formation of the zebrafish pronephros.
Perner, Developmental biology 2007 (PubMed)- GeneRIF: While wt1a has a more fundamental and early role in pronephros development and is essential for the formation of glomerular structures, wt1b functions at later stages of nephrogenesis.
XP_418708 transcription factor Sp4 isoform X1 from Gallus gallus
36% identity, 9% coverage
- A clustered set of three Sp-family genes is ancestral in the Metazoa: evidence from sequence analysis, protein domain structure, developmental expression patterns and chromosomal location
Schaeper, BMC evolutionary biology 2010 - “...NP_989935 ], Gg _Sp2 [GenBank: XP_423405 ], Gg _Sp3 [GenBank: NP_989934 ], Gg _Sp4 [GenBank: XP_418708 ], Gg _Sp5 [GenBank: NP_001038149 ], Gg _Sp8 [GenBank: AAU04515.1 ], Gg _Sp9 [GenBank: AAU04516.1 ], Fr_Sp1 [GenBank: CAAB01000453.1 ], Fr_Sp2 [GenBank: CAAB01001586.1 ], Fr_Sp3 [GenBank: CAAB01000508.1 ], Fr_Sp3-like [GenBank:...”
NP_001106179 zinc finger protein SNAI1 from Bos taurus
43% identity, 29% coverage
- Potential Involvement of Snail Members in Neuronal Survival and Astrocytic Migration during the Gecko Spinal Cord Regeneration
Shen, Frontiers in cellular neuroscience 2017 - “...Snail3 (NP_840101); mouse Mus musculus Snail1 (NP_035557), Snail2 (NP_035545), Snail3 (NP_038942); cattle Bos taurus Snail1 (NP_001106179), Snail2 (NP_001029710), Snail3 (NP_001179562); dolphin Lipotes vexillifer Snail1 (XP_007446447), Snail2 (XP_007464078), Snail3 (XP_007468498); bird Nipponia nippon Snail1 (XP_009463837), Snail2 (XP_009471359), Snail3 (XP_009475765); bird Haliaeetus leucocephalus Snail1 (XP_010567958), Snail2 (XP_010572691), Snail3...”
ZN649_HUMAN / Q9BS31 Zinc finger protein 649 from Homo sapiens (Human) (see paper)
NP_075562 zinc finger protein 649 from Homo sapiens
48% identity, 15% coverage
XP_009101147 zinc finger protein SNAI2 from Serinus canaria
42% identity, 28% coverage
XP_006112231 zinc finger protein SNAI2 from Pelodiscus sinensis
42% identity, 28% coverage
- Potential Involvement of Snail Members in Neuronal Survival and Astrocytic Migration during the Gecko Spinal Cord Regeneration
Shen, Frontiers in cellular neuroscience 2017 - “...(XP_009101147); green anole Anolis carolinensis Snail1 (XP_003220701), Snail2 (XP_003223554), Snail3 (XP_003228606); turtle Pelodiscus sinensis Snail2 (XP_006112231), Snail3 (XP_006125863); turtle Chelonia mydas Snail2 (XP_007058841), Snail3 (XP_007059405); frog Xenopus tropicalis Snail1 (NP_989267), Snail2 (NP_989424), Snail3 (XP_002933720); zebrafish Danio rerio Snail1a (NP_571141), Snail1b (NP_571064), Snail2 (NP_001008581), Snail3 (NP_001070853). Phylogenetic...”
XP_007446447 zinc finger protein SNAI1 from Lipotes vexillifer
43% identity, 29% coverage
- Potential Involvement of Snail Members in Neuronal Survival and Astrocytic Migration during the Gecko Spinal Cord Regeneration
Shen, Frontiers in cellular neuroscience 2017 - “...Snail3 (NP_038942); cattle Bos taurus Snail1 (NP_001106179), Snail2 (NP_001029710), Snail3 (NP_001179562); dolphin Lipotes vexillifer Snail1 (XP_007446447), Snail2 (XP_007464078), Snail3 (XP_007468498); bird Nipponia nippon Snail1 (XP_009463837), Snail2 (XP_009471359), Snail3 (XP_009475765); bird Haliaeetus leucocephalus Snail1 (XP_010567958), Snail2 (XP_010572691), Snail3 (XP_010578013); bird Serinus canaria Snail1 (XP_009091543), Snail2 (XP_009101147); green...”
NP_001166183 transcription factor Sp3 isoform 3 from Homo sapiens
36% identity, 10% coverage
- SP3-induced Timeless transcription contributes to cell growth of lung adenocarcinoma cells.
Tian, PloS one 2024 - GeneRIF: SP3-induced Timeless transcription contributes to cell growth of lung adenocarcinoma cells.
- Specificity protein 1/3 regulate T-cell acute lymphoblastic leukemia cell proliferation and apoptosis through β-catenin by acting as targets of miR-495-3p.
Zheng, Annals of hematology 2024 (PubMed)- GeneRIF: Specificity protein 1/3 regulate T-cell acute lymphoblastic leukemia cell proliferation and apoptosis through beta-catenin by acting as targets of miR-495-3p.
- Caspase-Mediated Cleavage of the Transcription Factor Sp3: Possible Relevance to Cancer and the Lytic Cycle of Kaposi's Sarcoma-Associated Herpesvirus.
Chen, Microbiology spectrum 2022 - GeneRIF: Caspase-Mediated Cleavage of the Transcription Factor Sp3: Possible Relevance to Cancer and the Lytic Cycle of Kaposi's Sarcoma-Associated Herpesvirus.
- SP3 is associated with migration, invasion, and Akt/PKB signalling in MDA-MB-231 breast cancer cells.
Mansour, Journal of biochemical and molecular toxicology 2021 (PubMed)- GeneRIF: SP3 is associated with migration, invasion, and Akt/PKB signalling in MDA-MB-231 breast cancer cells.
- A novel Lnc408 maintains breast cancer stem cell stemness by recruiting SP3 to suppress CBY1 transcription and increasing nuclear β-catenin levels.
Wen, Cell death & disease 2021 - GeneRIF: A novel Lnc408 maintains breast cancer stem cell stemness by recruiting SP3 to suppress CBY1 transcription and increasing nuclear beta-catenin levels.
- Sp3 Transcription Factor Cooperates with the Kaposi's Sarcoma-Associated Herpesvirus ORF50 Protein To Synergistically Activate Specific Viral and Cellular Gene Promoters.
Chen, Journal of virology 2020 - GeneRIF: Sp3 Transcription Factor Cooperates with the Kaposi's Sarcoma-Associated Herpesvirus ORF50 Protein To Synergistically Activate Specific Viral and Cellular Gene Promoters.
- Transcription of human β4-galactosyltransferase 3 is regulated by differential DNA binding of Sp1/Sp3 in SH-SY5Y human neuroblastoma and A549 human lung cancer cell lines.
Tange, Glycobiology 2019 (PubMed)- GeneRIF: These findings suggest that the transcription of the b4GalT3 gene is regulated by differential DNA binding of Sp3 and Sp1 in neuroblastoma and lung cancer. The increased expression of b4GalT3 in neuroblastoma may be ascribed to the enhanced expression of Sp3, which is observed for various cancers.
- HPV8 activates cellular gene expression mainly through Sp1/3 binding sites.
Kirschberg, Virology 2019 (PubMed)- GeneRIF: The authors identified that human papillomavirus type 8 E7 protein exerts control over cellular gene expression through Sp1/3 binding motifs, which may contribute to the virus-mediated keratinocyte transformation and subsequent fibronectin-dependent invasion.
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SP3_HUMAN / Q02447 Transcription factor Sp3; SPR-2 from Homo sapiens (Human) (see 15 papers)
NP_003102 transcription factor Sp3 isoform 1 from Homo sapiens
36% identity, 10% coverage
- function: Transcriptional factor that can act as an activator or repressor depending on isoform and/or post-translational modifications. Binds to GT and GC boxes promoter elements. Competes with SP1 for the GC-box promoters. Weak activator of transcription but can activate a number of genes involved in different processes such as cell-cycle regulation, hormone-induction and house-keeping.
subunit: Interacts with HLTF; the interaction may be required for basal transcriptional activity of HLTF. Interacts with HDAC1; the interaction deacetylates SP3 and regulates its transcriptional activity. Interacts with HDAC2 (preferably the CK2-phosphorylated form); the interaction deacetylates SP3 and regulates its transcriptional activity. Interacts with MEIS2 isoform 4 and PBX1 isoform PBX1a. - Systematic proteomics profiling of lysine crotonylation of the lung at Pseudoglandular and Canalicular phases in human fetus.
Wang, Proteome science 2023 - “...Q9Y618 Nuclear receptor corepressor 2 NCOR2 2.975 Up P20719 Homeobox protein Hox-A5 HOXA5 2.412 Up Q02447 Transcription factor Sp3 SP3 2.286 Up P09429 High mobility group protein B1 HMGB1 2.279 Up P10600 Transforming growth factor beta-3 proprotein TGFB3 2.008 Up Q6NYC1 Bifunctional arginine demethylase and lysyl-hydroxylase...”
- The Dual Functions of Andrographolide in the Epstein-Barr Virus-Positive Head-and-Neck Cancer Cells: The Inhibition of Lytic Reactivation of the Epstein-Barr Virus and the Induction of Cell Death.
Heawchaiyaphum, International journal of molecular sciences 2023 - “...(Uniprot ID: Q9UKV0), MEF2D (Uniprot ID: Q14814), SP1 (Uniprot ID: P08047), and SP3 (Uniprot ID: Q02447), were submitted to SWISS-MODEL, https://swissmodel.expasy.org/ (accessed on 24 November 2021) [ 72 ], a protein prediction software, to build the putative 3D structures. The stereochemistry of proteins was evaluated using...”
- Functionally Annotating Regulatory Elements in the Equine Genome Using Histone Mark ChIP-Seq.
Kingsley, Genes 2019 - “...Motif ID Consensus Adjusted p -Value UniProt Entry Adipose 1 SP3 VCCACGCCCMC 1.49 10 10 Q02447 2 TFDP1 VSGCGGGAAVN 1.74 10 10 Q14186 3 TFAP2A HGCCYSAGGCD 3.27 10 10 P05549 4 TFAP2C YGCCYBVRGGCA 4.56 10 10 Q92754 6 KLF16 GMCACGCCCCC 5.81 10 9 Q9BXK1 Brain 1...”
- “...16 P05549 2 TFAP2B YGCCCBVRGGCA 1.29 10 13 Q92481 3 SP3 VCCACGCCCMC 2.69 10 13 Q02447 4 TFAP2C YGCCYBVRGGCA 4.99 10 13 Q92754 5 KLF16 GMCACGCCCCC 1.06 10 12 Q9BXK1 Heart 1 MZF1 BGGGGA 2.23 10 5 P28698 2 Ascl2 ARCAGCTGCY 7.06 10 4 Q99929 3...”
- Lysine Acetylation Goes Global: From Epigenetics to Metabolism and Therapeutics.
Ali, Chemical reviews 2018 - “...436 , 437 Sp1 K703 KAT3B Unknown P08047 315 , 438 Sp3 K551 KAT3B Unknown Q02447 439 - 441 SREBPIc K289, K309 KAT3B SIRT1 P36956 442 STAT2 K390 KAT3A Unknown P52630 412 , 443 STAT3 K49, K87, K685 KAT3A, KAT3B KDAC1, KDAC2, KDAC3 P40763 444 -...”
- SP and KLF Transcription Factors in Digestive Physiology and Diseases.
Kim, Gastroenterology 2017 - “...for this figure are listed per UniProtKB database as follows: SP1 (P08047), SP2 (Q02086), SP3 (Q02447), SP4 (Q02446), SP5 (Q6BEB4), SP6 (Q3SY56), SP7 (Q87DD2), SP8 (Q8IXZ3), SP9 (P0CG40), KLF1 (Q13351), KLF2 (Q9Y5W3), KLF3 (P57682), KLF4 (Q43474), KLF5 (Q13887), KLF6 (Q99612), KLF7 (O75840), KLF8 (O95600), KLF9 (Q13886),...”
- Prediction of protein-DNA interactions of transcription factors linking proteomics and transcriptomics data.
Kondrakhin, EuPA open proteomics 2016 - “...1.67 1.16E-04 Q13952 p p nuclear transcription factor Y, gamma SP3 Sp3 V$SP1_Q6_01 2.37 1.36E-85 Q02447 p p Sp3 transcription factor RREB1 RREB-1 V$RREB1_01 1.33 1.28E-12 Q92766 p p-dn ras responsive element binding protein 1 NR2F2 COUP-TF2 V$DR4_Q2 1.34 8.36E-15 P24468 p p nuclear receptor subfamily...”
- Krüppel-like factors in cancer progression: three fingers on the steering wheel.
Limame, Oncotarget 2014 - “...SP1 TFSP1 BC062539 P08047 785 80.7 SP2 KIAA0048 NM_003110 Q02086 613 64.9 SP3 SPR-2 AY070137 Q02447 781 81.9 SP4 SPR-1,HF1B, MGC130008, MGC130009 NM_003112 Q02446 784 82 SP5 AB096175 Q6BEB4 398 42 SP7 OSX BC113613 Q8TDD2 431 45 SP8 BC038669 Q8IXZ3 490 48.7 SP9 ZNF990 NM_001145250 P0CG40...”
- Evidence against a beneficial effect of irisin in humans.
Raschke, PloS one 2013 - “...http://bioinfo.iitk.ac.in ), resulted in only three human genes, which are translated to the protein level (Q02447, Q15561, Q99594). Nevertheless, to challenge this bioinformatic analysis, we monitored the ability of the human transcript to be translated into protein. Overexpression of human FNDC5 in HEK293 cells with ATA...”
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- A clustered set of three Sp-family genes is ancestral in the Metazoa: evidence from sequence analysis, protein domain structure, developmental expression patterns and chromosomal location
Schaeper, BMC evolutionary biology 2010 - “...XP_793203.2 ], Hs _Sp1 [GenBank: NP_612482 ], Hs _Sp2 [GenBank: NP_003101 ], Hs _Sp3 [GenBank: NP_003102 ], Hs _Sp4 [GenBank: NP_003103 ], Hs _Sp5 [GenBank: NP_001003845 ], Hs _Sp6 [GenBank: NP_954871 ], Hs _Sp7 [GenBank: NP_690599 ], Hs _Sp8 [GenBank: NP_874359 ], Hs _Sp9 [GenBank: NP_001138722...”
NP_446257 zinc finger protein SNAI1 from Rattus norvegicus
43% identity, 29% coverage
- Changes in snail and SRF expression in the kidneys of diabetic rats during ageing.
Kostic, Acta histochemica 2020 (PubMed)- GeneRIF: Changes in snail and SRF expression in the kidneys of diabetic rats during ageing.
- Metastasis-associated protein 1 promotes epithelial-mesenchymal transition in idiopathic pulmonary fibrosis by up-regulating Snail expression.
Qian, Journal of cellular and molecular medicine 2020 - GeneRIF: Metastasis-associated protein 1 promotes epithelial-mesenchymal transition in idiopathic pulmonary fibrosis by up-regulating Snail expression.
- Neuregulin‑1 impacting bone marrow mesenchymal stem cell migration is conducive to functional recovery following spinal cord injury.
Yi, Molecular medicine reports 2019 - GeneRIF: The NRG1modified bone marrow mesenchymal stem cells (BMSCs) promoted the functional recovery of spinal cord injury (SCI). These results suggested that NRG1 significantly promoted the expression of MMP2 by upregulating the expression of Snail, and enhanced cell migration of the BMSCs conducive to the functional recovery of SCI
- HIF-1α regulates EMT via the Snail and β-catenin pathways in paraquat poisoning-induced early pulmonary fibrosis.
Zhu, Journal of cellular and molecular medicine 2016 - GeneRIF: HIF-1A regulates epithelial-mesenchymal transition via the Snail and beta-catenin pathways in paraquat poisoning-induced early pulmonary fibrosis.
- Transcription factor snail regulates tumor necrosis factor α-mediated synovial fibroblast activation in the rheumatoid joint.
Chen, Arthritis & rheumatology (Hoboken, N.J.) 2015 (PubMed)- GeneRIF: Transcription factor snail regulates tumor necrosis factor alpha-mediated synovial fibroblast activation in the rheumatoid joint.
- MiR-30a regulates the atrial fibrillation-induced myocardial fibrosis by targeting snail 1.
Yuan, International journal of clinical and experimental pathology 2015 - GeneRIF: Suggest that miR-30a target snail 1 protein may be related to atrial fibrillation-induced myocardial fibrosis.
- Snail mediates PDGF-BB-induced invasion of rat bone marrow mesenchymal stem cells in 3D collagen and chick chorioallantoic membrane.
Lu, Journal of cellular physiology 2013 (PubMed)- GeneRIF: these in vitro and in vivo data identify snail as a critical mediator for rBMMSC invasion induced by PDGF-BB.
- Angiotensin II contributes to diabetic renal dysfunction in rodents and humans via Notch1/Snail pathway.
Gagliardini, The American journal of pathology 2013 - GeneRIF: Angiotensin II plays a role in glomerular injury in experimental and human diabetic nephropathy via persistent activation of Notch1 and Snail signaling in podocytes resulting in down-regulation of nephrin expression.
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Q5VV52 Zinc finger protein 691 from Homo sapiens
48% identity, 24% coverage
XP_419196 zinc finger protein SNAI2 isoform X1 from Gallus gallus
42% identity, 28% coverage
- Alcohol-mediated calcium signals dysregulate pro-survival Snai2/PUMA/Bcl2 networks to promote p53-mediated apoptosis in avian neural crest progenitors.
Flentke, Birth defects research 2019 - GeneRIF: Alcohol-mediated calcium signals dysregulate pro-survival Snai2/PUMA/Bcl2 networks to promote p53-mediated apoptosis in avian neural crest progenitors.
- Snail2 and Zeb2 repress P-cadherin to define embryonic territories in the chick embryo.
Acloque, Development (Cambridge, England) 2017 (PubMed)- GeneRIF: Snail1/E-cadherin axis described in the early mouse embryo corresponds to Snail2/P-cadherin in the chick, but both Snail factors and Zeb2 fulfil a similar role in chick and mouse in directly repressing ectodermal cadherin genes to contribute to the delamination of mesendodermal precursors at gastrulation and the proper specification of the neural ectoderm during neural induction
- Novel insight into the function and regulation of alphaN-catenin by Snail2 during chick neural crest cell migration.
Jhingory, Developmental biology 2010 - GeneRIF: Novel insight into the function and regulation of alphaN-catenin by SNAIL2 during chick neural crest cell migration is reported.
- Snail2 directly represses cadherin6B during epithelial-to-mesenchymal transitions of the neural crest.
Taneyhill, Development (Cambridge, England) 2007 - GeneRIF: Cadherin6B is a direct target of Snail2 repression in vivo and in the context of the EMT that characterizes neural crest development.
- Oscillations of the snail genes in the presomitic mesoderm coordinate segmental patterning and morphogenesis in vertebrate somitogenesis.
Dale, Developmental cell 2006 (PubMed)- GeneRIF: Results report the cyclic mRNA expression of Snail 1 and Snail 2 in the mouse and chick presomitic mesoderm (PSM), respectively.
- Relative expression of Slug, RhoB, and HNK-1 in the cranial neural crest of the early chicken embryo.
Del, Developmental dynamics : an official publication of the American Association of Anatomists 2004 (PubMed)- GeneRIF: expression in the cranial neural crest of the early embryo (Slug; HNK-1)
- Expression of chicken slug and snail in mesenchymal components of the developing central nervous system.
Marin, Developmental dynamics : an official publication of the American Association of Anatomists 2004 (PubMed)- GeneRIF: Slug is expressed in the meninges and in the pericytes/vascular smooth muscle cells of the brain, the spinal cord and other embryonic tissues; snail is expressed in the stroma of the choroid plexus of both the developmng hindbrain and the forebrain
SP3_CHICK / Q90WR8 Transcription factor Sp3 from Gallus gallus (Chicken) (see paper)
NP_989934 transcription factor Sp3 from Gallus gallus
36% identity, 10% coverage
- function: Transcriptional factor that can act as an activator or repressor depending on post-translational modifications. Binds to GT and GC boxes promoter elements. Competes with SP1 for the GC-box promoters. Weak activator of transcription (By similarity). Required for activation of SPARC transcription.
subunit: Interacts with HDAC1 and HDAC2; the interaction deacetylates SP3 and regulates its transcriptional activity (By similarity). Interacts with v-Jun. - A clustered set of three Sp-family genes is ancestral in the Metazoa: evidence from sequence analysis, protein domain structure, developmental expression patterns and chromosomal location
Schaeper, BMC evolutionary biology 2010 - “...NP_998125 ], Gg _Sp1 [GenBank: NP_989935 ], Gg _Sp2 [GenBank: XP_423405 ], Gg _Sp3 [GenBank: NP_989934 ], Gg _Sp4 [GenBank: XP_418708 ], Gg _Sp5 [GenBank: NP_001038149 ], Gg _Sp8 [GenBank: AAU04515.1 ], Gg _Sp9 [GenBank: AAU04516.1 ], Fr_Sp1 [GenBank: CAAB01000453.1 ], Fr_Sp2 [GenBank: CAAB01001586.1 ], Fr_Sp3...”
- Transcription of the chicken Grin1 gene is regulated by the activity of SP3 and NRSF in undifferentiated cells and neurons.
Moreno-González, Bioscience reports 2008 (PubMed)- GeneRIF: These results demonstrate a dual role of SP3 in regulating the expression of the Grin1 gene, by repressing transcription in the 5'-UTR in undifferentiated cells as well as acting as a transcription factor, increasing Grin1 gene transcription in neurons.
- SP3/SP1 transcription activity regulates specific expression of collagen type X in hypertrophic chondrocytes.
Magee, The Journal of biological chemistry 2005 (PubMed)- GeneRIF: the SP3/SP1 ratio and Dlx5 are important regulators of the proximal Col10a1 promoter in hypertrophic cartilage
- Sp1 and Sp3 regulate transcription of the chicken GAS41 gene.
Hübner, Biochimica et biophysica acta (PubMed)- GeneRIF: localized the GAS41 promoter close to the 3' end of the lysozyme gene and found that Sp1 and Sp3 bind to this promoter
SNAI1_MOUSE / Q02085 Zinc finger protein SNAI1; Protein snail homolog 1; Protein sna from Mus musculus (Mouse) (see 8 papers)
NP_035557 zinc finger protein SNAI1 from Mus musculus
43% identity, 29% coverage
- function: Involved in induction of the epithelial to mesenchymal transition (EMT), formation and maintenance of embryonic mesoderm, growth arrest, survival and cell migration. Binds to 3 E-boxes of the E-cadherin gene promoter and to the promoters of CLDN7 and KRT8 and, in association with histone demethylase KDM1A which it recruits to the promoters, causes a decrease in dimethylated H3K4 levels and represses transcription. Involved in induction of the epithelial to mesenchymal transition (EMT), formation and maintenance of embryonic mesoderm, growth arrest, survival and cell migration. Binds to 3 E-boxes of the E-cadherin/CDH1 gene promoter and to the promoters of CLDN7 and KRT8 and, in association with histone demethylase KDM1A which it recruits to the promoters, causes a decrease in dimethylated H3K4 levels and represses transcription. The N-terminal SNAG domain competes with histone H3 for the same binding site on the histone demethylase complex formed by KDM1A and RCOR1, and thereby inhibits demethylation of histone H3 at 'Lys-4' (in vitro) (By similarity). During EMT, involved with LOXL2 in negatively regulating pericentromeric heterochromatin transcription (PubMed:24239292). SNAI1 recruits LOXL2 to pericentromeric regions to oxidize histone H3 and repress transcription which leads to release of heterochromatin component CBX5/HP1A, enabling chromatin reorganization and acquisition of mesenchymal traits (PubMed:24239292). Associates with EGR1 and SP1 to mediate 12-O- tetradecanoylphorbol-13-acetate (TPA)-induced up-regulation of CDKN2B, possibly by binding to the CDKN2B promoter region 5'-TCACA-3'. In addition, may also activate the CDKN2B promoter by itself.
subunit: Interacts with LOXL2 and LOXL3 (By similarity). Interacts with FBXL14 and GSK3B. Interacts with BTRC; interaction occurs when it is phosphorylated on the destruction motif. Interacts (via SNAG domain) with LIMD1 (via LIM domains), WTIP (via LIM domains) and AJUBA (via LIM domains). Interacts (via N-terminal region) with CSNK2A1. Interacts with EGR1 upon TPA induction. Interacts (via N-terminal region) with LATS2; the interaction is dependent on LATS2 kinase activity but independent of SNAI1 Thr-203 phosphorylation. Interacts (via zinc fingers) with KPNB1 and TNPO1; the interactions mediate nuclear import. Interacts (via zinc fingers) with KPNA1; the interaction disrupts the transport complex with KPNB1 and prevents nuclear import increasing SNAI1 degradation in the cytoplasm. Interacts (via zinc fingers) with KPNA2; the interaction, in combination with KPNB1, mediates nuclear import. Interacts with KPNA4; this interaction mediates nuclear import. May interact (via zinc fingers) with IPO7. Interacts (via zinc fingers) with PARP1; the interaction requires SNAI1 to be poly-ADP-ribosylated and non-phosphorylated (active) by GSK3B. Interacts (via SNAG domain) with KDM1A; the interaction is necessary for the down-regulation of dimethylated H3K4 mark and promoter activity of E-cadherin/CDH1, CDN7 and KRT8. Interacts with TP53/p53 and (via zinc fingers) with NOTCH1 (via intracellular domain); the interactions induce SNAI1 degradation via MDM2-mediated ubiquitination and inhibit SNAI1-induced cell invasion. Interacts with MDM2; the interaction promotes SNAI1 ubiquitination. Interacts (via zinc fingers) with CSNK1E. Interacts with PAK1.
disruption phenotype: Embryos die early in gestation, exhibiting defects in gastrulation and mesoderm formation. Recessive lethal mutation. - The Snail repressor recruits EZH2 to specific genomic sites through the enrollment of the lncRNA HOTAIR in epithelial-to-mesenchymal transition
Battistelli, Oncogene 2017 - “...(human EZH2 i.d.: Q15910; mouse EZH2 i.d.: Q61188; human Snail i.d.: O43623; mouse Snail i.d. Q02085). Sequence alignment was obtained using EMBOSS Water with default parameters. Data shown in Supplementary Figure 4 were produced using an in-house developed script. We thank I Bozzoni and SA Ciafr...”
- OGG1 promoted lung fibrosis by activating fibroblasts via interacting with Snail1.
Song, International immunopharmacology 2024 (PubMed)- GeneRIF: OGG1 promoted lung fibrosis by activating fibroblasts via interacting with Snail1.
- Hepatic Snai1 and Snai2 promote liver regeneration and suppress liver fibrosis in mice.
Wang, Cell reports 2024 - GeneRIF: Hepatic Snai1 and Snai2 promote liver regeneration and suppress liver fibrosis in mice.
- USP22 aggravated diabetic renal tubulointerstitial fibrosis progression through deubiquitinating and stabilizing Snail1.
Zhao, European journal of pharmacology 2023 (PubMed)- GeneRIF: USP22 aggravated diabetic renal tubulointerstitial fibrosis progression through deubiquitinating and stabilizing Snail1.
- USP2 promotes cell proliferation and metastasis in choroidal melanoma via stabilizing Snail.
Wei, Journal of cancer research and clinical oncology 2023 (PubMed)- GeneRIF: USP2 promotes cell proliferation and metastasis in choroidal melanoma via stabilizing Snail.
- Microenvironmental Snail1-induced immunosuppression promotes melanoma growth.
Arumi-Planas, Oncogene 2023 - GeneRIF: Microenvironmental Snail1-induced immunosuppression promotes melanoma growth.
- Formation of an invasion-permissive matrix requires TGFβ/SNAIL1-regulated alternative splicing of fibronectin.
Franco-Valls, Breast cancer research : BCR 2023 - GeneRIF: Formation of an invasion-permissive matrix requires TGFbeta/SNAIL1-regulated alternative splicing of fibronectin.
- Intestinal epithelial SNAI1 promotes the occurrence of colorectal cancer by enhancing EMT and Wnt/β-catenin signaling.
Qing, Medical oncology (Northwood, London, England) 2023 (PubMed)- GeneRIF: Intestinal epithelial SNAI1 promotes the occurrence of colorectal cancer by enhancing EMT and Wnt/beta-catenin signaling.
- Synergistic effects of ISL1 and KDM6B on non-alcoholic fatty liver disease through the regulation of SNAI1.
Zhao, Molecular medicine (Cambridge, Mass.) 2022 - GeneRIF: Synergistic effects of ISL1 and KDM6B on non-alcoholic fatty liver disease through the regulation of SNAI1.
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XP_010572691 zinc finger protein SNAI2 from Haliaeetus leucocephalus
42% identity, 28% coverage
SNAI2_RAT / O08954 Zinc finger protein SNAI2; Neural crest transcription factor Slug; Protein snail homolog 2 from Rattus norvegicus (Rat) (see paper)
NP_037167 zinc finger protein SNAI2 from Rattus norvegicus
42% identity, 28% coverage
- function: Transcriptional repressor that modulates both activator- dependent and basal transcription. Involved in the generation and migration of neural crest cells. Plays a role in mediating RAF1-induced transcriptional repression of the TJ protein, occludin (OCLN) and subsequent oncogenic transformation of epithelial cells. Represses BRCA2 expression by binding to its E2-box-containing silencer and recruiting CTBP1 and HDAC1 in breast cells. In epidermal keratinocytes, binds to the E-box in ITGA3 promoter and represses its transcription. Involved in the regulation of ITGB1 and ITGB4 expression and cell adhesion and proliferation in epidermal keratinocytes. Binds to E-box2 domain of BSG and activates its expression during TGFB1-induced epithelial-mesenchymal transition (EMT) in hepatocytes. Represses E- Cadherin/CDH1 transcription via E-box elements. Involved in osteoblast maturation. Binds to RUNX2 and SOC9 promoters and may act as a positive and negative transcription regulator, respectively, in osteoblasts. Binds to CXCL12 promoter via E-box regions in mesenchymal stem cells and osteoblasts. Plays an essential role in TWIST1-induced EMT and its ability to promote invasion and metastasis (By similarity).
subunit: Interacts (via SNAG domain) with LIMD1 (via LIM domains), WTIP (via LIM domains) and AJUBA (via LIM domains) (By similarity). Interacts (via zinc fingers) with KPNA2, KPNB1 and TNPO1. May interact (via zinc fingers) with IPO7 (By similarity). - FSCN1 is upregulated by SNAI2 and promotes epithelial to mesenchymal transition in head and neck squamous cell carcinoma.
Wang, Cell biology international 2017 (PubMed)- GeneRIF: SNAI2 overexpression significantly increased FSCN1 expression at both mRNA and protein level. FSCN1 overexpression reduced the expression of E-cadherin and Claudin 1, but increased the expression of Vimentin and N-cadherin in SCC9 and SCC-15 cells. It is inferred that FSCN1 is a downstream effector of SNAI2 in promoting EMT in HNSC cells.
- Expression of Slug in S100β-protein-positive cells of postnatal developing rat anterior pituitary gland.
Horiguchi, Cell and tissue research 2016 (PubMed)- GeneRIF: S100beta-positive cells express Slug and that its expression is important for subsequent migration and proliferation.
- Green tea polyphenols reverse cooperation between c-Rel and CK2 that induces the aryl hydrocarbon receptor, slug, and an invasive phenotype.
Belguise, Cancer research 2007 (PubMed)- GeneRIF: Coexpression of c-Rel and CK2 or DMBA induce Slug and maammary cancer invasiveness.
- E-cadherin is regulated by the transcriptional repressor SLUG during Ras-mediated transformation of intestinal epithelial cells.
Schmidt, Surgery 2005 (PubMed)- GeneRIF: Oncogenic ras induces upregulation of the transcriptional repressor SLUG and subsequent downregulation of the junctional protein E-cadherin.
SNAI2_HUMAN / O43623 Zinc finger protein SNAI2; Neural crest transcription factor Slug; Protein snail homolog 2 from Homo sapiens (Human) (see 11 papers)
NP_003059 zinc finger protein SNAI2 from Homo sapiens
42% identity, 28% coverage
- function: Transcriptional repressor that modulates both activator- dependent and basal transcription. Involved in the generation and migration of neural crest cells. Plays a role in mediating RAF1-induced transcriptional repression of the TJ protein, occludin (OCLN) and subsequent oncogenic transformation of epithelial cells (By similarity). Represses BRCA2 expression by binding to its E2-box- containing silencer and recruiting CTBP1 and HDAC1 in breast cells. In epidermal keratinocytes, binds to the E-box in ITGA3 promoter and represses its transcription. Involved in the regulation of ITGB1 and ITGB4 expression and cell adhesion and proliferation in epidermal keratinocytes. Binds to E-box2 domain of BSG and activates its expression during TGFB1-induced epithelial-mesenchymal transition (EMT) in hepatocytes. Represses E-Cadherin/CDH1 transcription via E-box elements. Involved in osteoblast maturation. Binds to RUNX2 and SOC9 promoters and may act as a positive and negative transcription regulator, respectively, in osteoblasts. Binds to CXCL12 promoter via E-box regions in mesenchymal stem cells and osteoblasts. Plays an essential role in TWIST1-induced EMT and its ability to promote invasion and metastasis.
subunit: Interacts (via SNAG domain) with LIMD1 (via LIM domains), WTIP (via LIM domains) and AJUBA (via LIM domains) (By similarity). Interacts (via zinc fingers) with KPNA2, KPNB1, and TNPO1. May interact (via zinc fingers) with IPO7. - The Snail repressor recruits EZH2 to specific genomic sites through the enrollment of the lncRNA HOTAIR in epithelial-to-mesenchymal transition
Battistelli, Oncogene 2017 - “...sequences were from UniProtKB (human EZH2 i.d.: Q15910; mouse EZH2 i.d.: Q61188; human Snail i.d.: O43623; mouse Snail i.d. Q02085). Sequence alignment was obtained using EMBOSS Water with default parameters. Data shown in Supplementary Figure 4 were produced using an in-house developed script. We thank I...”
- The application of the open pharmacological concepts triple store (open PHACTS) to support drug discovery research
Ratnam, PloS one 2014 - “...GO:0060556 regulation of vitamin D biosynthetic process GO:0010957 negative regulation of vitamin D biosynthetic process O43623 Zinc finger protein SNAI2 NO O95863 Zinc finger protein SNAI1 NO P19838 Nuclear factor NF-kappa-B p105 subunit NO Q99684 Zinc finger protein Gfi-1 NO GO:0070562 regulation of vitamin D receptor...”
- Novel application of multi-stimuli network inference to synovial fibroblasts of rheumatoid arthritis patients.
Kupfer, BMC medical genomics 2014 - “...BMP4 652 Bone morphogenetic protein 4 P12644 SF GC08M049880_at SNAI2 6591 Snail homolog 2 (Drosophila) O43623 TF GC20P048599_at SNAI1 6615 Snail homolog 1 (Drosophila) O95863 TF GC17P070117_at SOX9 6662 SRY (sex determining region Y)-box 9 P48436 TF GC19M041837_at TGFB1 7040 Transforming growth factor, beta 1 P01137...”
- A survey of well conserved families of C2H2 zinc-finger genes in Daphnia
Seetharam, BMC genomics 2010 - “...(Dappu-290491) 191:57-1323 OVOL2 (Q9BRP0) SNAIL SNAIL3 (NP_840101) SNAIL (P08044) K02D7 (NP_499902) Dappu- 53927 39:954341-955431 SNAIL2 (O43623) ESG (P25932) SCRT1(NP_491001) Dappu- 129982 110:193847-194734 SNAIL1 (O95863) WOR (NP_476601) CES1 (NP_492338) ESG (Dappu-347447) 23:1247838-1249532 hSCRT1 (Q9BWW7) SCRT (Q24140) Dappu- 61957 110:238640-239641 hSCRT2 (Q9NQ03) CG12605 (NP_995996) CG12391 (NP_610639) CG17181 (NP_612040)...”
- SNAI2/FTH1P3/miR-218-5p Positive Feedback Loop Promotes Colorectal Cancer Metastasis.
Deng, Biochemical genetics 2024 (PubMed)- GeneRIF: SNAI2/FTH1P3/miR-218-5p Positive Feedback Loop Promotes Colorectal Cancer Metastasis.
- Hsa_circ_0001707 regulates endothelial-mesenchymal transition in esophageal squamous cell carcinoma via miR-203a-3p/Snail2 pathway.
Gao, Environmental toxicology 2024 (PubMed)- GeneRIF: Hsa_circ_0001707 regulates endothelial-mesenchymal transition in esophageal squamous cell carcinoma via miR-203a-3p/Snail2 pathway.
- P4HA2 involved in SLUG-associated EMT predicts poor prognosis of patients with KRAS-positive colorectal cancer.
El-Deek, Medical molecular morphology 2024 - GeneRIF: P4HA2 involved in SLUG-associated EMT predicts poor prognosis of patients with KRAS-positive colorectal cancer.
- The deubiquitinase USP7 and E3 ligase TRIM21 regulate vasculogenic mimicry and malignant progression of RMS by balancing SNAI2 homeostasis.
Zhang, Journal of experimental & clinical cancer research : CR 2024 - GeneRIF: The deubiquitinase USP7 and E3 ligase TRIM21 regulate vasculogenic mimicry and malignant progression of RMS by balancing SNAI2 homeostasis.
- T-plastin contributes to epithelial-mesenchymal transition in human lung cancer cells through FAK/AKT/Slug axis signaling pathway.
Park, BMB reports 2024 - GeneRIF: T-plastin contributes to epithelial-mesenchymal transition in human lung cancer cells through FAK/AKT/Slug axis signaling pathway.
- TGFβ1, SNAIL2, and PAPP-A Expression in Placenta of Gestational Diabetes Mellitus Patients.
He, Journal of diabetes research 2024 - GeneRIF: TGFbeta1, SNAIL2, and PAPP-A Expression in Placenta of Gestational Diabetes Mellitus Patients.
- Homeobox B9 promotes the invasion and metastasis of hepatocellular carcinoma cells via the EZH2-MIR203A-SNAI2 axis.
Zhang, Journal of translational medicine 2024 - GeneRIF: Homeobox B9 promotes the invasion and metastasis of hepatocellular carcinoma cells via the EZH2-MIR203A-SNAI2 axis.
- Cisplatin‑resistant germ cell tumor models: An exploration of the epithelial‑mesenchymal transition regulator SLUG.
Cardoso, Molecular medicine reports 2024 - GeneRIF: Cisplatin-resistant germ cell tumor models: An exploration of the epithelial-mesenchymal transition regulator SLUG.
- More
2ebtA / Q13887 Solution structure of three tandem repeats of zf-c2h2 domains from human kruppel-like factor 5
46% identity, 72% coverage
NP_035545 zinc finger protein SNAI2 from Mus musculus
42% identity, 28% coverage
- Hepatic Snai1 and Snai2 promote liver regeneration and suppress liver fibrosis in mice.
Wang, Cell reports 2024 - GeneRIF: Hepatic Snai1 and Snai2 promote liver regeneration and suppress liver fibrosis in mice.
- SNAI2 promotes the malignant transformation of oral leukoplakia by modulating p-EMT.
Shang, Oral diseases 2023 (PubMed)- GeneRIF: SNAI2 promotes the malignant transformation of oral leukoplakia by modulating p-EMT.
- LepRb+ cell-specific deletion of Slug mitigates obesity and nonalcoholic fatty liver disease in mice.
Kim, The Journal of clinical investigation 2023 - GeneRIF: LepRb+ cell-specific deletion of Slug mitigates obesity and nonalcoholic fatty liver disease in mice.
- Slug, a Stress-Induced Transcription Factor, Stimulates Herpes Simplex Virus 1 Replication and Transactivates a cis-Regulatory Module within the VP16 Promoter.
Santos, Journal of virology 2023 - GeneRIF: Slug, a Stress-Induced Transcription Factor, Stimulates Herpes Simplex Virus 1 Replication and Transactivates a cis-Regulatory Module within the VP16 Promoter.
- Long Noncoding RNA MIAT Modulates Chronic Retinal Ischemia-Reperfusion Injury in Mice via the microRNA-203-3p/SNAI2 Axis.
Fu, Chemical research in toxicology 2023 (PubMed)- GeneRIF: Long Noncoding RNA MIAT Modulates Chronic Retinal Ischemia-Reperfusion Injury in Mice via the microRNA-203-3p/SNAI2 Axis.
- Irradiation Activates MZF1 to Inhibit miR-541-5p Expression and Promote Epithelial-Mesenchymal Transition (EMT) in Radiation-Induced Pulmonary Fibrosis (RIPF) by Upregulating Slug.
Liang, International journal of molecular sciences 2021 - GeneRIF: Irradiation Activates MZF1 to Inhibit miR-541-5p Expression and Promote Epithelial-Mesenchymal Transition (EMT) in Radiation-Induced Pulmonary Fibrosis (RIPF) by Upregulating Slug.
- Inhibition of Slug effectively targets leukemia stem cells via the Slc13a3/ROS signaling pathway.
Zhang, Leukemia 2020 - GeneRIF: Genetic or pharmacological inhibition of SLUG or forced expression of Slc13a3 suppresses the growth of human AML cells.
- The transcriptional repressor SNAI2 impairs neuroblastoma differentiation and inhibits response to retinoic acid therapy.
Vrenken, Biochimica et biophysica acta. Molecular basis of disease 2020 (PubMed)- GeneRIF: SNAI2 maintains progenitor-like features in neuroblastoma cells.
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XP_009471359 LOW QUALITY PROTEIN: zinc finger protein SNAI2 from Nipponia nippon
42% identity, 29% coverage
- Potential Involvement of Snail Members in Neuronal Survival and Astrocytic Migration during the Gecko Spinal Cord Regeneration
Shen, Frontiers in cellular neuroscience 2017 - “...dolphin Lipotes vexillifer Snail1 (XP_007446447), Snail2 (XP_007464078), Snail3 (XP_007468498); bird Nipponia nippon Snail1 (XP_009463837), Snail2 (XP_009471359), Snail3 (XP_009475765); bird Haliaeetus leucocephalus Snail1 (XP_010567958), Snail2 (XP_010572691), Snail3 (XP_010578013); bird Serinus canaria Snail1 (XP_009091543), Snail2 (XP_009101147); green anole Anolis carolinensis Snail1 (XP_003220701), Snail2 (XP_003223554), Snail3 (XP_003228606); turtle Pelodiscus...”
SNAI2_XENLA / Q91924 Zinc finger protein SNAI2; Protein slug-alpha; Protein snail homolog 2; Snail protein homolog Slug; xSlu from Xenopus laevis (African clawed frog) (see 5 papers)
NP_001079751 zinc finger protein SNAI2 from Xenopus laevis
42% identity, 29% coverage
NP_989424 zinc finger protein SNAI2 from Xenopus tropicalis
42% identity, 29% coverage
SP3_MOUSE / O70494 Transcription factor Sp3 from Mus musculus (Mouse) (see paper)
NP_001018052 transcription factor Sp3 isoform 1 from Mus musculus
36% identity, 10% coverage
- function: Transcriptional factor that can act as an activator or repressor depending on isoform and/or post-translational modifications. Binds to GT and GC boxes promoter elements. Competes with SP1 for the GC-box promoters. Weak activator of transcription but can activate a number of genes involved in different processes such as cell-cycle regulation, hormone-induction and house-keeping (By similarity).
subunit: Interacts with HLTF; the interaction may be required for basal transcriptional activity of HLTF. Interacts with HDAC1; the interaction deacetylates SP3 and regulates its transcriptional activity. Interacts with HDAC2 (preferably the CK2-phosphorylated form); the interaction deacetylates SP3 and regulates its transcriptional activity. Ceramides can also regulate acetylation/deacetylation events through altering the interaction of HDAC with SP3. Interacts with MEIS2 isoform Meis2D and PBX1 isoform PBX1a (By similarity). - NEAT1 inhibits the angiogenic activity of cerebral arterial endothelial cells by inducing the M1 polarization of microglia through the AMPK signaling pathway.
Chen, Cellular & molecular biology letters 2024 - “...Gene Ontology Table1 Information of top 20 up-regulated proteins Accession Gene Description Fold change (log2) O70494 Sp3 Transcription factor Sp3 6.99 Q6ZWY3 Rps27l 40S ribosomal protein S27-like 6.29 Q6ZWY8 Tmsb10 Thymosin beta-10 5.62 P62073 Timm10 translocase of inner mitochondrial membrane 10 5.20 P97411 Ica1 Islet cell...”
- Understanding the Molecular Mechanisms of Incomptine A in Treating Non-Hodgkin Lymphoma Associated with U-937 Cells: Bioinformatics Approaches, Part I.
Calzada, Pharmaceuticals (Basel, Switzerland) 2024 - “...Nuclear pore complex protein Nup54 Nup54 1.63055079 WC Q9Z2D6 Methyl-CpG-binding protein 2 Mecp2 1.77536209 WC O70494 Transcription factor Sp3 Sp3 1.97910072 WC P27661 Histone H2AX; Histone H2A type 1-A H2afx 2.1980563 WC P84244 Histone H3.3; Histone H3.3C H3f3a 2.25523584 WC P62806 Histone H4 H4c11 or Hist1h4a...”
- Tandem mass tag-based quantitative proteomic analysis of effects of multiple sevoflurane exposures on the cerebral cortex of neonatal and adult mice.
Feng, Frontiers in neurology 2022 - Angiotensin-converting enzyme inhibitor promotes angiogenesis through Sp1/Sp3-mediated inhibition of notch signaling in male mice.
Lu, Nature communications 2023 - GeneRIF: Angiotensin-converting enzyme inhibitor promotes angiogenesis through Sp1/Sp3-mediated inhibition of notch signaling in male mice.
- Sp3 is essential for normal lung morphogenesis and cell cycle progression during mouse embryonic development.
McCoy, Development (Cambridge, England) 2023 - GeneRIF: Sp3 is essential for normal lung morphogenesis and cell cycle progression during mouse embryonic development.
- The HIV-Tat protein interacts with Sp3 transcription factor and inhibits its binding to a distal site of the sod2 promoter in human pulmonary artery endothelial cells.
Manes, Free radical biology & medicine 2020 - GeneRIF: The HIV-Tat protein interacts with Sp3 transcription factor and inhibits its binding to a distal site of the sod2 promoter in human pulmonary artery endothelial cells.
- Robust hematopoietic specification requires the ubiquitous Sp1 and Sp3 transcription factors.
Gilmour, Epigenetics & chromatin 2019 - GeneRIF: Authors studied the cooperation of Sp1 with its closest paralogue Sp3 in hematopoietic development and demonstrate that Sp1 and Sp3 binding sites largely overlap.
- Sp3 controls fibroblast growth factor receptor 4 gene activity during myogenic differentiation.
Cavanaugh, Gene 2017 (PubMed)- GeneRIF: Sp3 binds and activates the FGFR4 promoter.
- Involvement of GATA1 and Sp3 in the activation of the murine STING gene promoter in NIH3T3 cells.
Xu, Scientific reports 2017 - GeneRIF: Sp3 interacts with the STING promoter and activates the basal transcription of the STING gene.
- Physiological TLR5 expression in the intestine is regulated by differential DNA binding of Sp1/Sp3 through simultaneous Sp1 dephosphorylation and Sp3 phosphorylation by two different PKC isoforms.
Thakur, Nucleic acids research 2016 - GeneRIF: This resulted in Sp1 displacement from the promoter and binding of Sp3 to it, leading to p300 recruitment and histone acetylation, activating transcription. This is the first study addressing the mechanisms of physiological TLR5 expression in the intestine. Additionally, a novel insight is gained into Sp1/Sp3-mediated gene regulation that may apply to other genes
- Transcription factors YY1, Sp1 and Sp3 modulate dystrophin Dp71 gene expression in hepatic cells.
Peñuelas-Urquides, The Biochemical journal 2016 (PubMed)- GeneRIF: Dp71 expression in hepatic cells is carried out, in part, by YY1-, Sp1- and Sp3-mediated transcription from the Dp71 promoter.
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NP_001082118 snail family zinc finger 2 S homeolog from Xenopus laevis
42% identity, 29% coverage
ZBT24_MOUSE / Q80X44 Zinc finger and BTB domain-containing protein 24; Bone morphogenetic protein-induced factor 1; Brain-specific protein 1; Zinc finger protein 450 from Mus musculus (Mouse) (see paper)
44% identity, 11% coverage
- function: May be involved in BMP2-induced transcription
subunit: Interacts with MN1.
Q3B725 Zinc finger and BTB domain-containing protein 24 from Rattus norvegicus
44% identity, 11% coverage
NP_001079828 Kruppel-like factor 17, gene 1 S homeolog from Xenopus laevis
46% identity, 17% coverage
KLF17_MOUSE / Q8CFA7 Krueppel-like factor 17; Germ cell-specific zinc finger protein; Zinc finger protein 393 from Mus musculus (Mouse) (see 2 papers)
NP_083692 Krueppel-like factor 17 from Mus musculus
39% identity, 23% coverage
NP_001082133 Kruppel-like factor 17 L homeolog from Xenopus laevis
46% identity, 17% coverage
NP_571064 snail family zinc finger 1b from Danio rerio
43% identity, 30% coverage
- The EMT transcription factor Snai1 maintains myocardial wall integrity by repressing intermediate filament gene expression.
Gentile, eLife 2021 - GeneRIF: The EMT transcription factor Snai1 maintains myocardial wall integrity by repressing intermediate filament gene expression.
- Cxcl12a induces snail1b expression to initiate collective migration and sequential Fgf-dependent neuromast formation in the zebrafish posterior lateral line primordium.
Neelathi, Development (Cambridge, England) 2018 - GeneRIF: snail1b expression is initiated by chemokines first encountered by leading primordium cells and its expression plays a crucial role in initiating collective migration of the posterior lateral line primordium.
- Potential Involvement of Snail Members in Neuronal Survival and Astrocytic Migration during the Gecko Spinal Cord Regeneration
Shen, Frontiers in cellular neuroscience 2017 - “...frog Xenopus tropicalis Snail1 (NP_989267), Snail2 (NP_989424), Snail3 (XP_002933720); zebrafish Danio rerio Snail1a (NP_571141), Snail1b (NP_571064), Snail2 (NP_001008581), Snail3 (NP_001070853). Phylogenetic tree constructed using the PHYML implementation of Maximum-Likelihood demonstrated that gecko Snail paralogs clustered with corresponding homologs of other vertebrates, suggesting an evolutionary conservation of...”
- Snail modulates the assembly of fibronectin via α5 integrin for myocardial migration in zebrafish embryos.
Qiao, Scientific reports 2014 - GeneRIF: The results provide the molecular mechanism how snai1b controls the morphogenesis of heart during embryonic development
- Snail1a and Snail1b cooperate in the anterior migration of the axial mesendoderm in the zebrafish embryo.
Blanco, Development (Cambridge, England) 2007 (PubMed)- GeneRIF: Snail genes not only act as inducers of epithelial-to-mesenchymal transition, but also as more general regulators of cell adhesion and movement.
- Snail3 orthologues in vertebrates: divergent members of the Snail zinc-finger gene family.
Manzanares, Development genes and evolution 2004 (PubMed)- GeneRIF: Snail genes lie in regions of extensive paralogy, revealing their common origin through segmental or chromosomal duplication
DAR1_DROME / Q9VZN4 Dendritic arbor reduction protein 1 from Drosophila melanogaster (Fruit fly) (see 2 papers)
NP_001097493 dendritic arbor reduction 1 from Drosophila melanogaster
40% identity, 10% coverage
- function: Transcriptional regulator which promotes dendrite growth by suppressing, either directly or indirectly, the expression of the microtubule-severing protein spas (PubMed:21368042). Determines multipolar neuron morphology in postmitotic neurons by positively regulating the expression of genes involved in nuclear positioning including several dynein genes and the nuclear migration protein nudC (PubMed:26490864).
disruption phenotype: Severely reduced growth of microtubule-based dendritic branches and elevated levels of microtubule-severing protein spas (PubMed:21368042). Gradual conversion of multipolar neurons into the bipolar or unipolar morphology (PubMed:26490864). - The Krüppel-Like Factor Dar1 Determines Multipolar Neuron Morphology.
Wang, The Journal of neuroscience : the official journal of the Society for Neuroscience 2015 - GeneRIF: The transcription factor Dar1 determines multipolar neuron morphology in postmitotic neurons by regulating genes involved in nuclear positioning.
NP_001008581 zinc finger protein SNAI2 from Danio rerio
42% identity, 30% coverage
XP_009295865 zinc finger protein SNAI2 isoform X1 from Danio rerio
42% identity, 31% coverage
ZIC3_XENLA / O57311 Zinc finger protein ZIC 3; XZic3; XlZic3; Zinc finger protein Zic3-A; Zinc finger protein of the cerebellum 3 from Xenopus laevis (African clawed frog) (see 9 papers)
42% identity, 16% coverage
- function: Probably acts as a transcriptional activator. May bind to the minimal GLI-consensus sequence 5'-GGGTGGTC-3'. Can determine the ectodermal cell fate and promote the earliest step of neural and neural crest development. Involved in establishing left-right asymmetry in the embryo.
NP_001081088 zinc finger protein ZIC 3 from Xenopus laevis
42% identity, 16% coverage
FGSG_06311 hypothetical protein from Fusarium graminearum PH-1
42% identity, 9% coverage
- Functional Characterization of Calcineurin-Responsive Transcription Factors Fg01341 and Fg01350 in Fusarium graminearum
Zhang, Frontiers in microbiology 2020 - “...a neighbor-joining method with 1000 bootstrap replications. Amino acids from F. graminearum (FGSG_01341, FGSG_01350, FGSG_10470, FGSG_06311, and FGSG_13711), C. neoformans (CNAG_00156), M. oryzae (MGG_05133), N. crassa (NCU07952), B. cinerea (BCIN_01g08230), A. fumigatus (AFUA_1G06900), and S. cerevisiae (CRZ1). Ca 2 + signals were transmitted by regulating the...”
- Genomic clustering and co-regulation of transcriptional networks in the pathogenic fungus Fusarium graminearum
Lawler, BMC systems biology 2013 - “...FGSG_01341 zf-C2H2 2 FG1, FG2.10 FGSG_01350 zf-C2H2 2 FG1, FG2.10 FGSG_02743 zf-C2H2 2 FG1, FG2.10 FGSG_06311 zf-C2H2 1 FG6 FGSG_06871 zf-C2H2 4 FG1, FG2.-10, FG2.-11, FG6 FGSG_12970 zf-C2H2 1 FG6 FGSG_08010 Zn_clus 2 FG1, FG2.10 The gene identifier of the putative regulator ( F. gr. gene...”
NP_989935 transcription factor Sp1 from Gallus gallus
36% identity, 10% coverage
- In vivo binding of Orc2 to a region of the chicken lysozyme GAS41 origin containing multiple Sp1-binding sites.
Hübner, DNA and cell biology 2012 (PubMed)- GeneRIF: Sp1 participates in recruiting Orc2 to the origin of lysozyme GAS41.
- A clustered set of three Sp-family genes is ancestral in the Metazoa: evidence from sequence analysis, protein domain structure, developmental expression patterns and chromosomal location
Schaeper, BMC evolutionary biology 2010 - “...NP_998406 ], Dr _Sp8-like [GenBank: NP_991113 ], Dr _Sp9 [GenBank: NP_998125 ], Gg _Sp1 [GenBank: NP_989935 ], Gg _Sp2 [GenBank: XP_423405 ], Gg _Sp3 [GenBank: NP_989934 ], Gg _Sp4 [GenBank: XP_418708 ], Gg _Sp5 [GenBank: NP_001038149 ], Gg _Sp8 [GenBank: AAU04515.1 ], Gg _Sp9 [GenBank: AAU04516.1...”
- Dynamic transcriptional regulatory complexes, including E2F4, p107, p130, and Sp1, control fibroblast growth factor receptor 1 gene expression during myogenesis.
Parakati, The Journal of biological chemistry 2005 (PubMed)- GeneRIF: activation and repression of FGFR1 gene transcription is governed by interplay between Sp1, p107, p130, and E2F4 in distinct transcriptional complexes during skeletal muscle development
- SP3/SP1 transcription activity regulates specific expression of collagen type X in hypertrophic chondrocytes.
Magee, The Journal of biological chemistry 2005 (PubMed)- GeneRIF: the SP3/SP1 ratio and Dlx5 are important regulators of the proximal Col10a1 promoter in hypertrophic cartilage
- Sp1 and Sp3 regulate transcription of the chicken GAS41 gene.
Hübner, Biochimica et biophysica acta (PubMed)- GeneRIF: localized the GAS41 promoter close to the 3' end of the lysozyme gene and found that Sp1 and Sp3 bind to this promoter
snail / CAE00182.1 snail protein from Cupiennius salei (see paper)
41% identity, 19% coverage
LOC107443696 protein snail homolog Sna from Parasteatoda tepidariorum
41% identity, 20% coverage
- Single-cell RNA sequencing of mid-to-late stage spider embryos: new insights into spider development
Medina-Jiménez, BMC genomics 2024 - “...the heart, and the appendages [ 88 , 118 ], and snail ( sna ) (LOC107443696) is prominently expressed in the developing nervous system of the American wandering spider Cupiennius salei [ 177 , 193 ]. In summary, these data suggest that Cluster-V cells are involved...”
- “...[ 113 , 126 ], reviewed in [ 47 ], and snail ( sna ) (LOC107443696), an important factor of stem cell maintenance in the developing nervous system (e.g. [ 9 , 27 ]. Both genes are prominently expressed in the developing CNS of spiders [...”
LOC578589 zinc finger protein ZIC 1 from Strongylocentrotus purpuratus
41% identity, 12% coverage
XP_003223554 zinc finger protein SNAI2 from Anolis carolinensis
42% identity, 28% coverage
AZF1_YEAST / P41696 Transcription factor AZF1; asparagine-rich zinc-finger protein 1 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see 9 papers)
NP_014756 Azf1p from Saccharomyces cerevisiae S288C
NP_014756, YOR113W Azf1p from Saccharomyces cerevisiae
41% identity, 8% coverage
- function: Transcription factor involved in the diauxic shift (PubMed:11839825, PubMed:16467472, PubMed:23549479). In the presence of glucose, activates carbon and energy metabolism genes, and in te presence of glycerol-lactate, activates genes needed for cell wall maintenance (PubMed:11839825, PubMed:16467472, PubMed:23549479). Binds to DNA elements with the sequence AAAAGAAA (A4GA3), a motif enriched in the promoters of AZF1-sensitive genes (PubMed:16467472, PubMed:23388641). Required for glucose induction of CLN3 transcription (PubMed:11839825). Also required for proper FLO11 expression (PubMed:23388641). May also function as a corepressor (PubMed:34019539).
function: As an intrinsically disordered protein, AZF1 is capable of forming the prion [AZF1+] that confers resistance to the drug radicicol in a gain-of-function manner but decreases the expression of AZF1's target genes.
disruption phenotype: Leads to a defect in the division of the nucleus (PubMed:9799362). Reduces the transcriptional induction of CLN3 by glucose (PubMed:11839825). - Defining the role of the polyasparagine repeat domain of the S. cerevisiae transcription factor Azf1p.
Stewart, PloS one 2021 - GeneRIF: Defining the role of the polyasparagine repeat domain of the S. cerevisiae transcription factor Azf1p.
- The function and properties of the Azf1 transcriptional regulator change with growth conditions in Saccharomyces cerevisiae.
Slattery, Eukaryotic cell 2006 - GeneRIF: This study shows that Azf1 activates genes needed for cell wall maintenance, there is a a marked growth defect in the azf1Delta cells at 37 degrees C in nonfermentable medium and Glucose produces conditions that destabilize the Azf1 protein.
- The Putative C2H2 Transcription Factor VadH Governs Development, Osmotic Stress Response, and Sterigmatocystin Production in Aspergillus nidulans.
Li, Cells 2022 - “...(XP_008598185.1), Metarhizium anisopliae (KFG78752.1), Magnaporthe oryzae (Mor: XP_003719876.1), Neurospora crassa (XP_961139.2) and Saccharomyces cerevisiae (Sce: NP_014756.3). Figure 2 Relative mRNA levels of vadH . ( A ) Relative expression levels of vadH in vosA and velB . ( B ) Relative expression levels of vadH in...”
- Investigating the Influence of Glycerol on the Utilization of Glucose in Yarrowia lipolytica Using RNA-Seq-Based Transcriptomics
Lubuta, G3 (Bethesda, Md.) 2019 - “...nucleotide-binding protein alpha subunit YALI1_A16891g YALI0A16841g 1.51 0.006 3.00E-88 131/243 (54%) similar to S. cerevisiae YOR113W AZF1 Zinc-finger transcription factor YALI1_A11439g YALI0A11473g 1.29 0.003 0.0 692/1266 (55%) similar to S. cerevisiae YKL209C STE6 Plasma membrane ATP-binding cassette (ABC) transporter required for the export of a-factor YALI1_C13910g...”
- “...cells ( Michaelis and Barrowman 2012 ). YALI1_A16891g is weakly similar to S. cerevisiae AZF1 (YOR113w), encoding an asparagine-rich zinc finger protein. It is expressed in both strains with the highest expression under glycerol. IBT shows a linear increase of the expression from glucose to glycerol,...”
- Characterization of global gene expression during assurance of lifespan extension by caloric restriction in budding yeast
Choi, Experimental gerontology 2013 (PubMed)- “...regulators of those significantly changed genes, including AZF1 (YOR113W), HSF1 (YGL073W) and XBP1 (YIL101C). Deletions of two genes, AZF1 and XBP1 (HSF1 is...”
- Transcriptomics of the rice blast fungus Magnaporthe oryzae in response to the bacterial antagonist Lysobacter enzymogenes reveals candidate fungal defense response genes
Mathioni, PloS one 2013 - “...element shared similarity (p-value 0.001) to the binding site for the AZF1 zinc-finger transcription factor (YOR113W) from the yeast Saccharomyces cerevisiae ( Figure 6A ). Two genes in this group, a CFEM domain-containing protein gene (MGG_07553.6) and a MSF quinate transporter (MGG_04225.6) were found to have...”
- The nuclear localization of SWI/SNF proteins is subjected to oxygen regulation
Dastidar, Cell & bioscience 2012 - “...cytosol in response to hypoxia in a shorter time period ORF name Gene name Description YOR113W AZF1 Involved in glucose induction of CLN3 transcription YML102W CAC2 Component of the chromatin assembly complex YKL022C CDC16 Subunit of the anaphase-promoting complex/cyclosome YFR036W CDC26 Subunit of the Anaphase-Promoting Complex/Cyclosome...”
- Lessons from the genome sequence of Neurospora crassa: tracing the path from genomic blueprint to multicellular organism
Borkovich, Microbiology and molecular biology reviews : MMBR 2004 - “...04561.1 08807.1 S. cerevisiae; 2.00e-15 S. cerevisiae NP_014756; 1.00e-49 Homo sapiens locus AAH07307; 4.00e-27 S. pombe NP_594109; 4e-25 S. pombe NP_594670;...”
- Yeast genome-wide expression analysis identifies a strong ergosterol and oxidative stress response during the initial stages of an industrial lager fermentation
Higgins, Applied and environmental microbiology 2003 - “...transduction of cell wall stress Cell cycle YCR093w YGR049w YOR113w YMR273c CDC39 SCM4 AZF1 ZDS1 6.4 4.5 4.4 3.8 Member of the CCR4-Not complex Suppresses...”
KLF15_HUMAN / Q9UIH9 Krueppel-like factor 15; Kidney-enriched krueppel-like factor from Homo sapiens (Human) (see 9 papers)
NP_054798 Krueppel-like factor 15 from Homo sapiens
39% identity, 17% coverage
- function: Transcriptional regulator that binds to the GA element of the CLCNKA promoter. Binds to the KCNIP2 promoter and regulates KCNIP2 circadian expression in the heart (By similarity). Is a repressor of CCN2 expression, involved in the control of cardiac fibrosis. It is also involved in the control of cardiac hypertrophy acting through the inhibition of MEF2A and GATA4 (By similarity). Involved in podocyte differentiation (By similarity). Inhibits MYOCD activity. Is a negative regulator of TP53 acetylation. Inhibits NF-kappa-B activation through repression of EP300-dependent RELA acetylation.
subunit: Interacts with MYOCD and EP300. - KLF15 Transcriptionally Activates ATG14 to Promote Autophagy and Attenuate Damage of ox-LDL-Induced HAECs.
Han, Molecular biotechnology 2024 (PubMed)- GeneRIF: KLF15 Transcriptionally Activates ATG14 to Promote Autophagy and Attenuate Damage of ox-LDL-Induced HAECs.
- Loss of KLF15 impairs endometrial receptivity by inhibiting EMT in endometriosis.
Huang, The Journal of endocrinology 2024 - GeneRIF: Loss of KLF15 impairs endometrial receptivity by inhibiting EMT in endometriosis.
- KLF15 maintains contractile phenotype of vascular smooth muscle cells and prevents thoracic aortic dissection by interacting with MRTFB.
Fang, The Journal of biological chemistry 2024 - GeneRIF: KLF15 maintains contractile phenotype of vascular smooth muscle cells and prevents thoracic aortic dissection by interacting with MRTFB.
- KLF15-activated MARCH2 boosts cell proliferation and epithelial-mesenchymal transition and presents diagnostic significance for hepatocellular carcinoma.
Ni, Experimental cell research 2024 (PubMed)- GeneRIF: KLF15-activated MARCH2 boosts cell proliferation and epithelial-mesenchymal transition and presents diagnostic significance for hepatocellular carcinoma.
- KLF15 alleviates oxidative stress and apoptosis of H/R-induced trophoblast cells to improve invasion and migration capacity via the activation of IGF1R.
Zheng, Tissue & cell 2024 (PubMed)- GeneRIF: KLF15 alleviates oxidative stress and apoptosis of H/R-induced trophoblast cells to improve invasion and migration capacity via the activation of IGF1R.
- Roles of Krüppel-Like Transcription Factors KLF6 and KLF15 in Proximal Tubular Metabolism.
Piret, Nephron 2023 (PubMed)- GeneRIF: Roles of Kruppel-Like Transcription Factors KLF6 and KLF15 in Proximal Tubular Metabolism.
- Krüppel-like factor 15 counteracts endoplasmic reticulum stress and suppresses lung fibroblast proliferation and extracellular matrix accumulation.
Han, Tissue & cell 2023 (PubMed)- GeneRIF: Kruppel-like factor 15 counteracts endoplasmic reticulum stress and suppresses lung fibroblast proliferation and extracellular matrix accumulation.
- The transcriptional regulator KLF15 is necessary for myoblast differentiation and muscle regeneration by activating FKBP5.
Gao, The Journal of biological chemistry 2023 - GeneRIF: The transcriptional regulator KLF15 is necessary for myoblast differentiation and muscle regeneration by activating FKBP5.
- More
- SP and KLF Transcription Factors in Digestive Physiology and Diseases.
Kim, Gastroenterology 2017 - “...KLF8 (O95600), KLF9 (Q13886), KLF10 (Q13118), KLF11 (O14901), KLF12 (Q9Y4X4), KLF13 (Q9Y2Y9), KLF14 (Q8TD49), KLF15 (Q9UIH9), KLF16 (Q9BXK1), and KLF17 (Q5JT82). Figure 2 Post-translational Modifications and Co-factors That Interact With SP and KLF Proteins SP/KLF protein is illustrated as a bar with the three zinc fingers...”
- Krüppel-like factors in cancer progression: three fingers on the steering wheel.
Limame, Oncotarget 2014 - “...NM_015995 Q9Y2Y9 288 31.2 KLF14 BTEB5, SP6, EPFN DQ534757 Q8TD94 323 33.1 KLF15 K-KLF NM_014079 Q9UIH9 416 44 KLF16 BTEB4, NSLP2, DRRF NM_031918 Q9BXK1 252 25.4 KLF17 ZNF393 NM_173484 Q5JT82 389 42.6 Ablebbreviations: AP2rep AP2 repressor, B basic, BCD B-cell derived protein, BTEB basic transcription element...”
- A survey of well conserved families of C2H2 zinc-finger genes in Daphnia
Seetharam, BMC genomics 2010 - “...scaffold_21:551156-551927 KLF10 (Q13118) KLF1E (Dappu-262162) scaffold_164:255538-257421 KLF11 (O14901) KLF12 (NP_009180) KLF13 (NP_057079) KLF14 (Q8TD94) KLF15 (Q9UIH9) KLF16 (Q9BXK1) KLF17 (Q5JT82) The updated list of SP and KLF homologs with their accession numbers found in Homo sapiens (Build 36.3 downloaded from ftp://ftp.ncbi.nih.gov/genomes/H_sapiens/ARCHIVE/BUILD.36.3 ) Drosophila melanogaster (Build 4.1,...”
Q9UL59 Zinc finger protein 214 from Homo sapiens
44% identity, 13% coverage
CCM_01294 C2H2 transcription factor Swi5 from Cordyceps militaris CM01
43% identity, 10% coverage
NP_872321 zinc finger protein 714 from Homo sapiens
43% identity, 14% coverage
NP_001071821 transcription factor protein from Ciona intestinalis
41% identity, 13% coverage
Z354A_MOUSE / Q61751 Zinc finger protein 354A; Kidney, ischemia, and developmentally-regulated protein 1; Renal transcription factor Kid-1; Transcription factor 17; TCF-17 from Mus musculus (Mouse) (see paper)
43% identity, 13% coverage
- function: It may play a role in renal development and may also be involved in the repair of the kidney after ischemia-reperfusion or folic acid administration.
LOC100115031 Krueppel-like factor 7 from Nasonia vitripennis
42% identity, 23% coverage
Q96N38 Zinc finger protein 714 from Homo sapiens
43% identity, 14% coverage
Z354B_MOUSE / Q9QXT9 Zinc finger protein 354B; Kidney, ischemia, and developmentally-regulated protein 2 from Mus musculus (Mouse) (see 2 papers)
43% identity, 13% coverage
- function: Transcriptional repressor that binds DNA upon activation by RAS proteins signal transduction to initiate transcriptional silencing through the recruitment of additional DNA-binding proteins, multisubunit complexes and chromatin-modifying activities to establish a platform for DNMT1 recruitment.
XP_006718372 zinc finger protein 214 isoform X2 from Homo sapiens
44% identity, 13% coverage
NP_001093452 transcription factor Sp2 from Danio rerio
36% identity, 12% coverage
- A clustered set of three Sp-family genes is ancestral in the Metazoa: evidence from sequence analysis, protein domain structure, developmental expression patterns and chromosomal location
Schaeper, BMC evolutionary biology 2010 - “...NP_796056 ], Mm _Sp9 [GenBank: NP_001005343 ], Dr _Sp1 [GenBank: NP_997827 ], Dr _Sp2 [GenBank: NP_001093452 ], Dr _Sp3 [GenBank: NP_001082967 ], Dr _Sp3-like [GenBank: XP_691096 ], Dr _Sp4 [GenBank: NP_956418 ], Dr _Sp5 [GenBank: NP_851304 ], Dr _Sp5-like [GenBank: NP_919352 ], Dr _Similar_to_Sp5 [GenBank: XP_001335730...”
XP_009304137 transcription factor Sp2 isoform X1 from Danio rerio
36% identity, 13% coverage
SNAI1_HUMAN / O95863 Zinc finger protein SNAI1; Protein snail homolog 1; Protein sna from Homo sapiens (Human) (see 27 papers)
NP_005976 zinc finger protein SNAI1 from Homo sapiens
43% identity, 29% coverage
- function: Involved in induction of the epithelial to mesenchymal transition (EMT), formation and maintenance of embryonic mesoderm, growth arrest, survival and cell migration (PubMed:10655587, PubMed:15647282, PubMed:20389281, PubMed:20562920, PubMed:21952048, PubMed:25827072). Binds to 3 E-boxes of the E-cadherin/CDH1 gene promoter and to the promoters of CLDN7 and KRT8 and, in association with histone demethylase KDM1A which it recruits to the promoters, causes a decrease in dimethylated H3K4 levels and represses transcription (PubMed:10655587, PubMed:20389281, PubMed:20562920). The N-terminal SNAG domain competes with histone H3 for the same binding site on the histone demethylase complex formed by KDM1A and RCOR1, and thereby inhibits demethylation of histone H3 at 'Lys-4' (in vitro) (PubMed:20389281, PubMed:21300290, PubMed:23721412). During EMT, involved with LOXL2 in negatively regulating pericentromeric heterochromatin transcription (PubMed:16096638). SNAI1 recruits LOXL2 to pericentromeric regions to oxidize histone H3 and repress transcription which leads to release of heterochromatin component CBX5/HP1A, enabling chromatin reorganization and acquisition of mesenchymal traits (By similarity). Associates with EGR1 and SP1 to mediate tetradecanoyl phorbol acetate (TPA)-induced up-regulation of CDKN2B, possibly by binding to the CDKN2B promoter region 5'-TCACA-3 (PubMed:20121949). In addition, may also activate the CDKN2B promoter by itself (PubMed:20121949).
subunit: Interacts (via SNAG domain) with WTIP (via LIM domains) (By similarity). Interacts (via SNAG domain) with LIMD1 (via LIM domains), and AJUBA (via LIM domains) (PubMed:18331720). Interacts with LOXL2 and LOXL3 (PubMed:16096638). Interacts with EGR1 upon TPA induction (PubMed:20121949). Interacts (via zinc fingers) with KPNB1 and TNPO1; the interactions mediate nuclear import (PubMed:15836774, PubMed:19386897, PubMed:21454664, PubMed:24699649). Interacts (via zinc fingers) with KPNA1; the interaction disrupts the transport complex with KPNB1 and prevents nuclear import increasing SNAI1 degradation in the cytoplasm (PubMed:21454664). Interacts (via zinc fingers) with KPNA2; the interaction, in combination with KPNB1, mediates nuclear import (PubMed:21454664). Interacts with KPNA4; this interaction mediates nuclear import (PubMed:21454664). May interact (via zinc fingers) with IPO7 (PubMed:19386897). Interacts (via zinc fingers) with PARP1; the interaction requires SNAI1 to be poly-ADP-ribosylated and non-phosphorylated (active) by GSK3B (PubMed:21577210). Interacts (via SNAG domain) with KDM1A (PubMed:20389281, PubMed:20562920, PubMed:21300290, PubMed:23721412). Interaction with KDM1A is necessary for the down-regulation of dimethylated H3K4 mark and promoter activity of E-cadherin/CDH1, CDN7 and KRT8 (PubMed:20389281, PubMed:20562920). Interacts with TP53/p53 and (via zinc fingers) with NOTCH1 (via intracellular domain); the interactions induce SNAI1 degradation via MDM2-mediated ubiquitination and inhibit SNAI1-induced cell invasion (PubMed:20385133). Interacts with MDM2; the interaction promotes SNAI1 ubiquitination (PubMed:20385133, PubMed:22128911). - UBE2E2 enhances Snail-mediated epithelial-mesenchymal transition and Nrf2-mediated antioxidant activity in ovarian cancer.
Hong, Cell death & disease 2023 - “...cells (CSCs) [ 4 ]. The zinc finger protein SNAI1 (also known as Snail; UniProt/Swiss-Prot: O95863, gene name SNAI1 ), represses the expression of a broad repertoire of epithelial genes, including E-cadherin/CDH1 , and is a master regulator of EMT in most cancers [ 5 ]....”
- Network Pharmacological Analysis and Experimental Study of the Antipharyngitis Mechanism of the Chaiqin Qingning Capsule
Wang, BioMed research international 2022 - “...Q9NWT6 Hypoxia-inducible factor 1-alpha HIF1A P10145 Interleukin-8 CXCL8 P16581 E-selectin SELE P06401 Progesterone receptor PGR O95863 Zinc finger protein SNAI1 SNAI1 P04637 ETS domain-containing protein Elk-1 TP53 P08588 Beta-1 adrenergic receptor ADRB1 P01375 Tumor necrosis factor TNF P55211 Caspase-9 CASP9 P14778 Interleukin-1 alpha IL1A P38936 Cyclin-dependent...”
- Degron masking outlines degronons, co-degrading functional modules in the proteome.
Guharoy, Communications biology 2022 - “...313 SKP2 (Q13309), CKS1B (P61024) CDK2 (P24941), b CCNE2 (O96020) Zinc finger protein SNAI1 (SNAI1, O95863) 95 DSGKGS 100 BTRC (Q9Y297) GSK3B (P49841) Hypoxia-inducible factor 1-alpha (HIF1A, Q16665) 400 LAPAAGDTIISLDF 413 VHL (P40337) EGLN1 (Q9GZT9), UBE2I (P63279), SUMO1 (P63165) Double-strand-break repair protein rad21 homolog (RAD21, O60216)...”
- Short Linear Motifs in Colorectal Cancer Interactome and Tumorigenesis.
Fasano, Cells 2022 - “...MYC_HUMAN 55 62 IWKKFE LLPTPPLS PSRRSG 2 Co-immunoprecipitation; western blotting [ 105 , 106 ] O95863, SNAI1 SNAI1_HUMAN 93 100 ELTSLS DEDSGKGS QPPSPP 3 Co-immunoprecipitation; western blotting; alanine scanning [ 107 , 108 ] O95644, NFATC1 NFAC1_HUMAN 238 287 245 294 GSPRHS PSTSPRAS VTEESW HSPTPS PHGSPRVS...”
- Anti-Inflammatory Activity of Sanjie Zhentong Capsule Assessed By Network Pharmacology Analysis of Adenomyosis Treatment
Du, Drug design, development and therapy 2020 - “...NTRK1 P21964 Catechol O-methyltransferase COMT P09488 Glutathione S-transferase Mu 1 GSTM1 P14780 Matrix metalloproteinase-9 MMP9 O95863 Zinc finger protein SNAI1 SNAI1 P03372 Estrogen receptor ESR1 P24385 G1/S-specific cyclin-D1 CCND1 P08254 Stromelysin-1 MMP3 P08253 72 kDa type IV collagenase MMP2 P09237 Matrilysin MMP7 P03956 Interstitial collagenase MMP1...”
- The application of the open pharmacological concepts triple store (open PHACTS) to support drug discovery research
Ratnam, PloS one 2014 - “...process GO:0010957 negative regulation of vitamin D biosynthetic process O43623 Zinc finger protein SNAI2 NO O95863 Zinc finger protein SNAI1 NO P19838 Nuclear factor NF-kappa-B p105 subunit NO Q99684 Zinc finger protein Gfi-1 NO GO:0070562 regulation of vitamin D receptor signaling pathway GO:0070563 negative regulation of...”
- Structural basis of GSK-3 inhibition by N-terminal phosphorylation and by the Wnt receptor LRP6.
Stamos, eLife 2014 - “...PP1 G-subunit 38 SPQPSR 42 SRRGSE PTEN 362 STSVTP (P60484) 366 TPVDSD Snail 96 SGKGSQ (O95863) 100 SQPPSP SREBP1a 426 TPPPSD (P36956) 430 SDAGSP Tau 525 SRSRTP (P10693) 548 TPPKSP 713 SPVVSG 717 SGDTSP TSC2 1379 SQPLSK (P49815) 1383 SKSSSS VDAC 51 TTKVTG (P21796) von Hippel-Lindau...”
- Novel application of multi-stimuli network inference to synovial fibroblasts of rheumatoid arthritis patients.
Kupfer, BMC medical genomics 2014 - “...SNAI2 6591 Snail homolog 2 (Drosophila) O43623 TF GC20P048599_at SNAI1 6615 Snail homolog 1 (Drosophila) O95863 TF GC17P070117_at SOX9 6662 SRY (sex determining region Y)-box 9 P48436 TF GC19M041837_at TGFB1 7040 Transforming growth factor, beta 1 P01137 SF GC01M228106_at WNT9A 7483 Wingless-type MMTV integration site family,...”
- More
- Protein kinase D activity is a risk biomarker in prostate cancer that drives cell invasion by a Snail/ERK dependent mechanism.
Cilleros-Rodríguez, Biochimica et biophysica acta. Molecular basis of disease 2024 (PubMed)- GeneRIF: Protein kinase D activity is a risk biomarker in prostate cancer that drives cell invasion by a Snail/ERK dependent mechanism.
- Dual role of Snail1 as transcriptional repressor and activator.
García, Biochimica et biophysica acta. Reviews on cancer 2024 (PubMed)- GeneRIF: Dual role of Snail1 as transcriptional repressor and activator.
- The Snail signaling branch downstream of the TGF-β/Smad3 pathway mediates Rho activation and subsequent stress fiber formation.
Motizuki, The Journal of biological chemistry 2024 - GeneRIF: The Snail signaling branch downstream of the TGF-beta/Smad3 pathway mediates Rho activation and subsequent stress fiber formation.
- Decidual stromal cells-derived exosomes incurred insufficient migration and invasion of trophoblast by disturbing of β-TrCP-mediated snail ubiquitination and degradation in unexplained recurrent spontaneous abortion.
Xiong, European journal of medical research 2024 - GeneRIF: Decidual stromal cells-derived exosomes incurred insufficient migration and invasion of trophoblast by disturbing of beta-TrCP-mediated snail ubiquitination and degradation in unexplained recurrent spontaneous abortion.
- KLF5 inhibits the migration and invasion in cervical cancer cell lines by regulating SNAI1.
Qu, Cancer biomarkers : section A of Disease markers 2024 - GeneRIF: KLF5 inhibits the migration and invasion in cervical cancer cell lines by regulating SNAI1.
- Ubiquitin-specific Protease 35 Promotes Gastric Cancer Metastasis by Increasing the Stability of Snail1.
Ma, International journal of biological sciences 2024 - GeneRIF: Ubiquitin-specific Protease 35 Promotes Gastric Cancer Metastasis by Increasing the Stability of Snail1.
- Co-expression of Twist and Snai1: predictor of poor prognosis and biomarker of treatment resistance in untreated prostate cancer.
Said, Molecular biology reports 2024 (PubMed)- GeneRIF: Co-expression of Twist and Snai1: predictor of poor prognosis and biomarker of treatment resistance in untreated prostate cancer.
- Growth differentiation factor-11 upregulates matrix metalloproteinase 2 expression by inducing Snail in human extravillous trophoblast cells.
Wu, Molecular and cellular endocrinology 2024 (PubMed)- GeneRIF: Growth differentiation factor-11 upregulates matrix metalloproteinase 2 expression by inducing Snail in human extravillous trophoblast cells.
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LOC102381513 LOW QUALITY PROTEIN: zinc finger protein 271-like from Alligator sinensis
44% identity, 6% coverage
- Epigenetic programming alterations in alligators from environmentally contaminated lakes
Guillette, General and comparative endocrinology 2016 - “...Lysosomal acid lipase/cholesteryl ester hydrolase-like Metabolism XM 006272247.1 B4GALNT3 Beta-1,4-N-acetyl-galactosaminyl transferase 3 Golgi XM 006265693.1 LOC102381513 Zinc finger protein 135-like Transcription XM 006036439.1 SLC16A7 Solute carrier family 16 (monocarboxylate transporter), member 7 Transport XM 005297971.2 V2R Vomeronasal type 2 receptor Receptor KJ847402.1 LOC102382251 Fatty acid desaturase...”
NP_001127821 Krueppel-like factor 15 from Sus scrofa
39% identity, 17% coverage
ZIC4_XENLA / A0JC51 Zinc finger protein ZIC 4; XlZic4; Zinc finger protein of the cerebellum 4 from Xenopus laevis (African clawed frog) (see paper)
NP_001121252 zinc finger protein ZIC 4 from Xenopus laevis
41% identity, 14% coverage
KLF15_MOUSE / Q9EPW2 Krueppel-like factor 15; Cardiovascular Krueppel-like factor from Mus musculus (Mouse) (see 7 papers)
39% identity, 17% coverage
- function: Transcriptional regulator that binds to the GA element of the CLCNKA promoter (By similarity). Binds to the KCNIP2 promoter and regulates KCNIP2 circadian expression in the heart. Is a repressor of CCN2 expression, involved in the control of cardiac fibrosis. Is also involved in the control of cardiac hypertrophy acting through the inhibition of MEF2A, GATA4 and MYOCD activity. Is a negative regulator of TP53 acetylation. Inhibits NF-kappa-B activation through repression of EP300-dependent RELA acetylation (By similarity). Involved in podocyte differentiation.
subunit: Interacts with MYOCD. Interacts with EP300 (By similarity).
disruption phenotype: KLF15 null mice are viable, but in response to pressure overload, they develop cardiac hypertrophy and fibrosis.
XP_006125863 zinc finger protein SNAI3 from Pelodiscus sinensis
45% identity, 33% coverage
- Potential Involvement of Snail Members in Neuronal Survival and Astrocytic Migration during the Gecko Spinal Cord Regeneration
Shen, Frontiers in cellular neuroscience 2017 - “...anole Anolis carolinensis Snail1 (XP_003220701), Snail2 (XP_003223554), Snail3 (XP_003228606); turtle Pelodiscus sinensis Snail2 (XP_006112231), Snail3 (XP_006125863); turtle Chelonia mydas Snail2 (XP_007058841), Snail3 (XP_007059405); frog Xenopus tropicalis Snail1 (NP_989267), Snail2 (NP_989424), Snail3 (XP_002933720); zebrafish Danio rerio Snail1a (NP_571141), Snail1b (NP_571064), Snail2 (NP_001008581), Snail3 (NP_001070853). Phylogenetic tree constructed...”
Q9VY72 Maternal gene required for meiosis, isoform H from Drosophila melanogaster
NP_572932 maternal gene required for meiosis, isoform I from Drosophila melanogaster
40% identity, 5% coverage
XP_017448423 Krueppel-like factor 15 isoform X1 from Rattus norvegicus
39% identity, 17% coverage
- Loss of KLF15 impairs endometrial receptivity by inhibiting EMT in endometriosis.
Huang, The Journal of endocrinology 2024 - GeneRIF: Loss of KLF15 impairs endometrial receptivity by inhibiting EMT in endometriosis.
- [KLF15/mTOR related proteins involved in effect of aerobic interval training on improving skeletal muscle lesions in rats with type 2 diabetes].
Liao, Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology 2022 (PubMed)- GeneRIF: [KLF15/mTOR related proteins involved in effect of aerobic interval training on improving skeletal muscle lesions in rats with type 2 diabetes].
- Krϋppel-like factor 15 suppresses renal glomerular mesangial cell proliferation via enhancing P53 SUMO1 conjugation.
Wu, Journal of cellular and molecular medicine 2021 - GeneRIF: Krupsilonppel-like factor 15 suppresses renal glomerular mesangial cell proliferation via enhancing P53 SUMO1 conjugation.
- MiR-137-3p exacerbates the ischemia-reperfusion injured cardiomyocyte apoptosis by targeting KLF15.
Zhao, Naunyn-Schmiedeberg's archives of pharmacology 2020 (PubMed)- GeneRIF: MiR-137-3p exacerbates the ischemia-reperfusion injured cardiomyocyte apoptosis by targeting KLF15.
- Estrogen receptor beta maintains expression of KLF15 to prevent cardiac myocyte hypertrophy in female rodents.
Hoa, Molecular and cellular endocrinology 2018 - GeneRIF: Angiotensin II stimulation of transforming growth factor beta expression in the myocytes activated p38alpha kinase via TAK1 kinase, inhibiting KLF15 expression.
- Left ventricular hypertrophy in experimental chronic kidney disease is associated with reduced expression of cardiac Kruppel-like factor 15.
Patel, BMC nephrology 2018 - GeneRIF: Loss of cardiac KLF15 in chronic kidney disease induced left ventricular hypertrophy, is associated with trophic and fibrotic signaling.
- KLF15 Overexpression Protects β-Aminopropionitrile-Induced Aortic Rupture in Rodent Model via Inhibiting Connective Tissue Growth Factor.
Zhan, The Thoracic and cardiovascular surgeon 2017 (PubMed)- GeneRIF: Overexpression of KLF15 can partially rescue aortic remodeling and aortic dissection formation in animal models by inhibiting CTGF expression.
- Resveratrol-Mediated Expression of KLF15 in the Ischemic Myocardium is Associated with an Improved Cardiac Phenotype.
Rogers, Cardiovascular drugs and therapy 2017 (PubMed)- GeneRIF: Resveratrol treatment induces KLF15 expression, which may, in part, explain its therapeutic efficacy to improve the cardiac phenotype following ischemic injury.
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KLF7_MOUSE / Q99JB0 Krueppel-like factor 7 from Mus musculus (Mouse) (see 5 papers)
46% identity, 24% coverage
- function: Transcriptional factor (PubMed:11245580). Plays a critical role in neuronal morphogenesis (PubMed:11336497, PubMed:15964824). Represses the corneal epithelium differentiation (By similarity). Acts also as a metabolic regulator, by modulating insulin sensitivity in pancreatic beta cells and skeletal muscle cells. Inhibits transcriptional inducers of adipogenesis and has a repressive role in the expression of several adipokines, including leptin (By similarity).
subunit: Interacts with FBXO38.
disruption phenotype: Deficient mice die within the first 3 days of life, showing little or no milk in the stomachs, hypopnea, cyanosis, olfactory bulb hypoplasia, axon outgrowth defects in the olfactory and optic nerves, defects of axon growth in the brain and reduced dendritic branching in the hippocampus.
XP_038303695 Krueppel-like factor 7 isoform X2 from Canis lupus familiaris
46% identity, 24% coverage
KLF7_HUMAN / O75840 Krueppel-like factor 7; Ubiquitous krueppel-like factor from Homo sapiens (Human) (see 4 papers)
46% identity, 24% coverage
- function: Transcriptional factor (PubMed:16339272, PubMed:9774444). Plays a critical role in neuronal morphogenesis and survival of sensory neurons (By similarity). Represses the corneal epithelium differentiation (PubMed:28916725). Acts also as a metabolic regulator, by modulating insulin sensitivity in pancreatic beta cells and skeletal muscle cells (PubMed:16339272). Inhibits transcriptional inducers of adipogenesis and has a repressive role in the expression of several adipokines, including leptin (PubMed:16339272).
subunit: Interacts with FBXO38. - SP and KLF Transcription Factors in Digestive Physiology and Diseases.
Kim, Gastroenterology 2017 - “...SP9 (P0CG40), KLF1 (Q13351), KLF2 (Q9Y5W3), KLF3 (P57682), KLF4 (Q43474), KLF5 (Q13887), KLF6 (Q99612), KLF7 (O75840), KLF8 (O95600), KLF9 (Q13886), KLF10 (Q13118), KLF11 (O14901), KLF12 (Q9Y4X4), KLF13 (Q9Y2Y9), KLF14 (Q8TD49), KLF15 (Q9UIH9), KLF16 (Q9BXK1), and KLF17 (Q5JT82). Figure 2 Post-translational Modifications and Co-factors That Interact With...”
- Krüppel-like factors in cancer progression: three fingers on the steering wheel.
Limame, Oncotarget 2014 - “...Q13887 457 50.8 KLF6 BCD1, COBEP, CBPB, ST12, GBF AF284036 Q99612 283 31.9 KLF7 U-KLF O75840 302 33.4 KLF8 BKLF3, ZNF741 NM_007250 O95600 359 39.3 KLF9 BTEB, BTEB1 NM_001206 Q13886 244 27.2 KLF10 TIEG, TIEG1, EGR NM_005655 Q13118 480 52.6 KLF11 F-KLF, TIEG2, MODY7 O14901 512...”
- A survey of well conserved families of C2H2 zinc-finger genes in Daphnia
Seetharam, BMC genomics 2010 - “...KLF5 (Q13887) LUNA (NP_995811) KLF3 (Dappu-27999) scaffold_1:1214746-1215144 KLF6 (Q99612) BTEB2 (NP_572185) LUNA (Dappu-310992) scaffold_3:2311937-2324470 KLF7 (O75840) CABUT (Dappu-312628) scaffold_6:1962325-1965508 KLF8 (O95600) KLF9 (Dappu-315814) scaffold_15:985228-986723 KLF9 (Q13886) BTEB2 (Dappu-50068) scaffold_21:551156-551927 KLF10 (Q13118) KLF1E (Dappu-262162) scaffold_164:255538-257421 KLF11 (O14901) KLF12 (NP_009180) KLF13 (NP_057079) KLF14 (Q8TD94) KLF15 (Q9UIH9) KLF16 (Q9BXK1)...”
6ml4A / Q80X44 Btb24 zinc fingers 4-8 with 19+1mer DNA oligonucleotide (sequence 3) (see paper)
44% identity, 54% coverage
- Ligands: dna; zinc ion (6ml4A)
NP_989585 zinc finger protein ZIC 1 from Gallus gallus
41% identity, 17% coverage
NP_571008 zinc finger protein ZIC 1 from Danio rerio
41% identity, 17% coverage
ZIC1_CHICK / Q8JJC0 Zinc finger protein ZIC 1; Zinc finger protein of the cerebellum 1 from Gallus gallus (Chicken) (see paper)
41% identity, 17% coverage
- function: Acts as a transcriptional activator. Involved in neurogenesis. Plays important roles in the early stage of organogenesis of the CNS, as well as during dorsal spinal cord development and maturation of the cerebellum. Binds to the minimal GLI-consensus sequence 5'-TGGGTGGTC-3' (By similarity).
NP_001257872 Krueppel-like factor 7 isoform 3 from Homo sapiens
46% identity, 27% coverage
NP_571798 Krueppel-like factor 17 from Danio rerio
47% identity, 18% coverage
- Cooperative contributions of the klf1 and klf17 genes in zebrafish primitive erythropoiesis.
Suzuki, Scientific reports 2023 - GeneRIF: Cooperative contributions of the klf1 and klf17 genes in zebrafish primitive erythropoiesis.
- Characterization of biklf/klf17-deficient zebrafish in posterior lateral line neuromast and hatching gland development.
Suzuki, Scientific reports 2019 - GeneRIF: Characterization of biklf/klf17-deficient zebrafish in posterior lateral line neuromast and hatching gland development.
- A Pou5f1/Oct4 dependent Klf2a, Klf2b, and Klf17 regulatory sub-network contributes to EVL and ectoderm development during zebrafish embryogenesis.
Kotkamp, Developmental biology 2014 (PubMed)- GeneRIF: used microarray expression profiles of klf2a, klf2b and klf17 knockdown and overexpression embryos to identify Klf target genes, which reveals that Klfs participate in specification of the extraembryonic enveloping layer
- Zebrafish KLF4 is essential for anterior mesendoderm/pre-polster differentiation and hatching.
Gardiner, Developmental dynamics : an official publication of the American Association of Anatomists 2005 (PubMed)- GeneRIF: zKLF4 is expressed within the pre-polster, an early mesendodermal site, and that it plays a critical role in the differentiation of these cells into hatching gland cells.
- Lessons from the genome sequence of Neurospora crassa: tracing the path from genomic blueprint to multicellular organism
Borkovich, Microbiology and molecular biology reviews : MMBR 2004 - “...4e-25 S. pombe NP_594670; 4.00e-36 Zebrafish NP_571798; 4.00e-12 S. cerevisiae NP_014371; 2.00e-37 Colletotrichum lagenarium CMR1; 2.00e-12 Nectria haematococca...”
XP_003228606 zinc finger protein SNAI3 from Anolis carolinensis
45% identity, 26% coverage
- Potential Involvement of Snail Members in Neuronal Survival and Astrocytic Migration during the Gecko Spinal Cord Regeneration
Shen, Frontiers in cellular neuroscience 2017 - “...Serinus canaria Snail1 (XP_009091543), Snail2 (XP_009101147); green anole Anolis carolinensis Snail1 (XP_003220701), Snail2 (XP_003223554), Snail3 (XP_003228606); turtle Pelodiscus sinensis Snail2 (XP_006112231), Snail3 (XP_006125863); turtle Chelonia mydas Snail2 (XP_007058841), Snail3 (XP_007059405); frog Xenopus tropicalis Snail1 (NP_989267), Snail2 (NP_989424), Snail3 (XP_002933720); zebrafish Danio rerio Snail1a (NP_571141), Snail1b (NP_571064),...”
B0X1K7 Zinc finger protein from Culex quinquefasciatus
48% identity, 9% coverage
ZIC1_HUMAN / Q15915 Zinc finger protein ZIC 1; Zinc finger protein 201; Zinc finger protein of the cerebellum 1 from Homo sapiens (Human) (see 3 papers)
NP_003403 zinc finger protein ZIC 1 from Homo sapiens
41% identity, 17% coverage
- function: Acts as a transcriptional activator. Involved in neurogenesis. Plays important roles in the early stage of organogenesis of the CNS, as well as during dorsal spinal cord development and maturation of the cerebellum. Involved in the spatial distribution of mossy fiber (MF) neurons within the pontine gray nucleus (PGN). Plays a role in the regulation of MF axon pathway choice. Promotes MF migration towards ipsilaterally-located cerebellar territories. May have a role in shear flow mechanotransduction in osteocytes. Retains nuclear GLI1 and GLI3 in the cytoplasm. Binds to the minimal GLI-consensus sequence 5'-TGGGTGGTC-3' (By similarity).
subunit: Interacts (via the C2H2-type domains 3, 4 and 5) with MDFIC (via the C2H2-type domains 3, 4 and 5). Interacts with GLI1; the interaction enhances transcription activation. Interacts with GLI2. Interacts with GLI3; the interaction enhances transcription activation (By similarity). - ZIC1 Dictates Osteogenesis Versus Adipogenesis in Human Mesenchymal Progenitor Cells Via a Hedgehog Dependent Mechanism.
Thottappillil, Stem cells (Dayton, Ohio) 2023 - GeneRIF: ZIC1 Dictates Osteogenesis Versus Adipogenesis in Human Mesenchymal Progenitor Cells Via a Hedgehog Dependent Mechanism.
- Mechanical-Stress-Related Epigenetic Regulation of ZIC1 Transcription Factor in the Etiology of Postmenopausal Osteoporosis.
Datta, International journal of molecular sciences 2022 - GeneRIF: Mechanical-Stress-Related Epigenetic Regulation of ZIC1 Transcription Factor in the Etiology of Postmenopausal Osteoporosis.
- Age-Related DNA Methylation in Normal Kidney Tissue Identifies Epigenetic Cancer Risk Susceptibility Loci in the ANKRD34B and ZIC1 Genes.
Serth, International journal of molecular sciences 2022 - GeneRIF: Age-Related DNA Methylation in Normal Kidney Tissue Identifies Epigenetic Cancer Risk Susceptibility Loci in the ANKRD34B and ZIC1 Genes.
- Common Variants Near ZIC1 and ZIC4 in Autopsy-Confirmed Multiple System Atrophy.
Hopfner, Movement disorders : official journal of the Movement Disorder Society 2022 - GeneRIF: Common Variants Near ZIC1 and ZIC4 in Autopsy-Confirmed Multiple System Atrophy.
- LINC01419-mediated epigenetic silencing of ZIC1 promotes metastasis in hepatocellular carcinoma through the PI3K/Akt signaling pathway.
Hou, Laboratory investigation; a journal of technical methods and pathology 2021 (PubMed)- GeneRIF: LINC01419-mediated epigenetic silencing of ZIC1 promotes metastasis in hepatocellular carcinoma through the PI3K/Akt signaling pathway.
- Transcriptional expression of ZICs as an independent indicator of survival in gliomas.
Han, Scientific reports 2021 - GeneRIF: Transcriptional expression of ZICs as an independent indicator of survival in gliomas.
- Zic1 suppresses gastric cancer metastasis by regulating Wnt/β-catenin signaling and epithelial-mesenchymal transition.
Ge, FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2020 (PubMed)- GeneRIF: Zic1 suppresses gastric cancer metastasis by regulating Wnt/beta-catenin signaling and epithelial-mesenchymal transition.
- Roles and correlation of FOXA1 and ZIC1 in breast cancer.
Zhang, Current problems in cancer 2020 (PubMed)- GeneRIF: Roles and correlation of FOXA1 and ZIC1 in breast cancer.
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- A survey of well conserved families of C2H2 zinc-finger genes in Daphnia
Seetharam, BMC genomics 2010 - “...CG11984 (NP_731306) ZK652.6 (NP_001023029) KCMF (Dappu-310981) 3:2220789-2222830 CG31642 (NP_723159) CG31835 (NP_723881) CG15286 (NP_609706) ZIC ZIC1 (Q15915) OPA (P39768) REF2 (Q94178) OPA (Dappu-290567) 104:131019-135418 ZIC2 (O95409) SUG (Q7K0S9) ZIC3 (O60481) ZIC4(Q8N9L1) ZIC5(Q96T25) OVO OVOL1 (O14753) OVOrb (P51521) LIN48 (Q19996) OVO (Dappu-290491) 191:57-1323 OVOL2 (Q9BRP0) SNAIL SNAIL3 (NP_840101)...”
ZIC1_MOUSE / P46684 Zinc finger protein ZIC 1; Zinc finger protein of the cerebellum 1 from Mus musculus (Mouse) (see 7 papers)
XP_008764676 zinc finger protein ZIC 1 isoform X1 from Rattus norvegicus
41% identity, 17% coverage
- function: Acts as a transcriptional activator. Involved in neurogenesis. Plays important roles in the early stage of organogenesis of the CNS, as well as during dorsal spinal cord development and maturation of the cerebellum. Involved in the spatial distribution of mossy fiber (MF) neurons within the pontine gray nucleus (PGN). Plays a role in the regulation of MF axon pathway choice. Promotes MF migration towards ipsilaterally-located cerebellar territories. May have a role in shear flow mechanotransduction in osteocytes. Retains nuclear GLI1 and GLI3 in the cytoplasm. Binds to the minimal GLI-consensus sequence 5'-TGGGTGGTC-3'.
subunit: Interacts (via the C2H2-type domains 3, 4 and 5) with MDFIC (via the C2H2-type domains 3, 4 and 5). Interacts with GLI1; the interaction enhances transcription activation. Interacts with GLI2. Interacts with GLI3; the interaction enhances transcription activation.
disruption phenotype: Mice show a cell mass decrease of the spinal dorsal horn, hypoplasia and abnormal foliation patterns in the cerebellum. - Behavioral effects of neonatal lesions on the cerebellar system.
Lalonde, International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience 2015 (PubMed)- GeneRIF: This study showed that spontaneous Zic1 mutations causing cerebellar pathology are impaired in motor functions during the neonatal period.
KLF6_HUMAN / Q99612 Krueppel-like factor 6; B-cell-derived protein 1; Core promoter element-binding protein; GC-rich sites-binding factor GBF; Proto-oncogene BCD1; Suppressor of tumorigenicity 12 protein; Transcription factor Zf9 from Homo sapiens (Human) (see 4 papers)
46% identity, 25% coverage
- function: Transcriptional activator (By similarity). Binds a GC box motif. Could play a role in B-cell growth and development.
subunit: Interacts with ZZEF1. - Computational identification of host genomic biomarkers highlighting their functions, pathways and regulators that influence SARS-CoV-2 infections and drug repurposing.
Mosharaf, Scientific reports 2022 - “...(KLF6, USP53, GUCY1A2, and PAG1) were downloaded from SWISS-MODEL 52 using UniProt 53 ID of Q99612, Q70EK8, P33402, and Q9NWQ8, respectively. The 3D structure of 3 TFs proteins (GATA2, SRF and YY1) were downloaded from PDB with source codes 5o9b, 1hbx, and 1ubd, respectively, and the...”
- Quantitative proteomic analysis of aberrant expressed lysine acetylation in gastrointestinal stromal tumors
Wang, Clinical proteomics 2021 - “...0.043665 Q96TA1 Niban-like protein 1 OS=Homo sapiens OX=9606 GN=FAM129B PE=1 SV=3 479 0.344 Down 0.0158443 Q99612 Krueppel-like factor 6 OS=Homo sapiens OX=9606 GN=KLF6 PE=1 SV=3 228 1.553 Up 0.045342 Q9BR76 Coronin-1B OS=Homo sapiens OX=9606 GN=CORO1B PE=1 SV=1 21 0.279 Down 0.043319 Q9BUL5 PHD finger protein 23...”
- SP and KLF Transcription Factors in Digestive Physiology and Diseases.
Kim, Gastroenterology 2017 - “...SP8 (Q8IXZ3), SP9 (P0CG40), KLF1 (Q13351), KLF2 (Q9Y5W3), KLF3 (P57682), KLF4 (Q43474), KLF5 (Q13887), KLF6 (Q99612), KLF7 (O75840), KLF8 (O95600), KLF9 (Q13886), KLF10 (Q13118), KLF11 (O14901), KLF12 (Q9Y4X4), KLF13 (Q9Y2Y9), KLF14 (Q8TD49), KLF15 (Q9UIH9), KLF16 (Q9BXK1), and KLF17 (Q5JT82). Figure 2 Post-translational Modifications and Co-factors That...”
- Krüppel-like factors in cancer progression: three fingers on the steering wheel.
Limame, Oncotarget 2014 - “...KLF5 I-KLF, C-KLF, BTEB2 AF287272 Q13887 457 50.8 KLF6 BCD1, COBEP, CBPB, ST12, GBF AF284036 Q99612 283 31.9 KLF7 U-KLF O75840 302 33.4 KLF8 BKLF3, ZNF741 NM_007250 O95600 359 39.3 KLF9 BTEB, BTEB1 NM_001206 Q13886 244 27.2 KLF10 TIEG, TIEG1, EGR NM_005655 Q13118 480 52.6 KLF11...”
- A survey of well conserved families of C2H2 zinc-finger genes in Daphnia
Seetharam, BMC genomics 2010 - “...KLF4 (O43474) CABUT (NP_608529) KLF1D (Dappu-262353) scaffold_168:128271-129531 KLF5 (Q13887) LUNA (NP_995811) KLF3 (Dappu-27999) scaffold_1:1214746-1215144 KLF6 (Q99612) BTEB2 (NP_572185) LUNA (Dappu-310992) scaffold_3:2311937-2324470 KLF7 (O75840) CABUT (Dappu-312628) scaffold_6:1962325-1965508 KLF8 (O95600) KLF9 (Dappu-315814) scaffold_15:985228-986723 KLF9 (Q13886) BTEB2 (Dappu-50068) scaffold_21:551156-551927 KLF10 (Q13118) KLF1E (Dappu-262162) scaffold_164:255538-257421 KLF11 (O14901) KLF12 (NP_009180) KLF13...”
- Gene expression pattern in Caco-2 cells following rotavirus infection
Cuadras, Journal of virology 2002 - “...2.4 5.4 3.8 2.6 2.3 2.4 Q9BYH8 Q03060 6.4 5.4 Q99612 4.3 2.8 Q13118 O00472 2.9 2.9 P05455 P20694 O76080 ZNF313 P35638 P41738 Q64127 Q9UKY1 P13941 P50539 P24468...”
P52741 Zinc finger protein 134 from Homo sapiens
45% identity, 18% coverage
- Mycobacterial and HIV infections up-regulated human zinc finger protein 134, a novel positive regulator of HIV-1 LTR activity and viral propagation.
Benjamin, PloS one 2014 - “...to UniProt database, hZNF-134 is classified as a Kruppel C2H2-type zinc-finger transcriptional regulator (UniProt ID: P52741) with 11 C2H2-type zinc finger domains ( Figure S3 ); however, its precise function in human cells is still not clear. Over-expression of hZNF-134 increased while siRNA mediated knockdown reduced...”
- “...S1 ). UniProt database classified hZNF-134 as a Kruppel C2H2-type zinc-finger transcriptional regulator (UniProt ID: P52741) with 11 C2H2-type zinc finger domains ( Figure S3 ). Though hZNF-134 was initially identified from the astrocyte cell lysate, the transcript levels of hZNF-134 were present in different HIV-1...”
- Comparative proteomics analysis of human gastric cancer
Li, World journal of gastroenterology 2008 - “...Theoretic pI Theoretic Mr (Da) Q03001 Q15771 Q14587 Q9NP86 P49796 Q13368 P52741 P04270 P20929 Q9H267 85 64 57 61 62 45 57 154 59 54 6.38 4.91 9.14 4.46 4.79...”
C4PGM0 Specificity protein 1 from Homo sapiens
38% identity, 24% coverage
NP_958869 Krueppel-like factor 6a from Danio rerio
46% identity, 25% coverage
NP_035933 Krueppel-like factor 6 from Mus musculus
46% identity, 23% coverage
Q5T619 Zinc finger protein 648 from Homo sapiens
XP_024309028 zinc finger protein 648 isoform X1 from Homo sapiens
42% identity, 14% coverage
- Differential Plasma Proteins Identified via iTRAQ-Based Analysis Serve as Diagnostic Markers of Pancreatic Ductal Adenocarcinoma
Chen, Disease markers 2023 - “...1 0.004223 0.812415 20 P52272 Heterogeneous nuclear ribonucleoprotein M (HNRNPM) 2 1 0.042055 0.778395 21 Q5T619 Zinc finger protein 648 (ZNF648) 2 1 0.002492 0.612377 22 P01009 Alpha-1-antitrypsin (SERPINA1) 68 35 0.035057 1.212389 23 P02748 Complement component C9 (C9) 32 17 0.021767 1.20568 24 P02545 Prelamin-A/C...”
- iTRAQ and PRM-Based Proteomic Analysis Provides New Insights into Mechanisms of Response to Triple Therapy in Patients with Rheumatoid Arthritis
Chen, Journal of inflammation research 2021 - “...14 Weeks Treatment UniProtKB ID Protein Name Protein Description Fold Change a p-value Reference Up-regulation Q5T619 ZNF648 Zinc finger protein 648 2.725262 1.46E-13 Q6VFQ6 HBB Hemoglobin beta chain (Fragment) 2.587354 2.41E-12 D3GKD8 HBG1 A-gamma globin Osilo variant 2.56063 4.16E-12 A0A0K0K1L1 HEL-S-282 Epididymis secretory protein Li 282...”
- Proteomic analysis of decidua in patients with recurrent pregnancy loss (RPL) reveals mitochondrial oxidative stress dysfunction
Yin, Clinical proteomics 2021 - “...erythrocytic 0.522704837 0.00569253 Q9NZD4 Alpha-hemoglobin-stabilizing protein 0.495830711 0.0123884 Q96T46 Hemoglobin alpha 2 (Fragment) 0.492646003 0.00386368 Q5T619 Zinc finger protein 648 0.492249489 0.000922952 B3VL05 Beta globin (Fragment) 0.483155107 0.00346729 Q53EU6 Glycerol-3-phosphate acyltransferase 3 0.477888471 0.00394492 B3KUX0 cDNA FLJ40831 fis, clone TRACH2012138, highly similar to Homo sapiens regulator...”
- Integrated Metabolomics and Proteomics Analysis Reveals Plasma Lipid Metabolic Disturbance in Patients With Parkinson's Disease
Hu, Frontiers in molecular neuroscience 2020 - “...intermediate layer protein 1 (CILP) 132.48 1.247 0.003 A9UFC0 Caspase 14 (CASP14) 27.65 2.077 0.010 Q5T619 Zinc finger protein 648 (ZNF648) 62.30 1.276 0.010 Q04756 Hepatocyte growth factor activator (HGFAC) 70.64 1.605 0.013 Q9UQ05 Potassium voltage-gated channel subfamily H member 4 (KCNH4) 111.62 1.213 0.014 E5RIF9...”
- Identification and Verification of the Main Differentially Expressed Proteins in Gastric Cancer via iTRAQ Combined with Liquid Chromatography-Mass Spectrometry
Gao, Analytical cellular pathology (Amsterdam) 2019 - “...H0YJL6 Ena/VASP-like protein (fragment) OS=Homo sapiens GN=EVL PE=1 SV=1 (H0YJL6_HUMAN) 2.036708 1.64 E -06 13 Q5T619 Zinc finger protein 648 OS=Homo sapiens GN=ZNF648 PE=2 SV=1 (ZN648_HUMAN) 2.035727 1.67 E -06 14 Q658S4 Putative uncharacterized protein DKFZp666N164 (fragment) OS=Homo sapiens GN=DKFZp666N164 PE=2 SV=1 (Q658S4_HUMAN) 1.990709 3.53 E...”
- iTRAQ and PRM-based quantitative proteomics in early recurrent spontaneous abortion: biomarkers discovery
Cui, Clinical proteomics 2019 - “...1 1.37 0.0164 B7Z3I9 Delta-aminolevulinic acid dehydratase OS=Homo sapiens PE=2 SV=1-[B7Z3I9_HUMAN] 3.19 1 1.27 0.0271 Q5T619 Zinc finger protein 648 OS=Homo sapiens GN=ZNF648 PE=2 SV=1-[ZN648_HUMAN] 2.11 1 1.92 0.0407 B4E3Q1 cDNA FLJ61580, highly similar to Calsyntenin-1 OS=Homo sapiens PE=2 SV=1-[B4E3Q1_HUMAN] 1.35 2 1.33 0.0336 F6UYG0 Serine/threonine-protein...”
- Evaluation of liver cirrhosis and hepatocellular carcinoma using Protein-Protein Interaction Networks.
Ehsani, Gastroenterology and hepatology from bed to bench 2016 - “...b Uniprotcode Gene name Degree Betweenness centrally P04792 HSP27 846 0.444179 Q14790 CASP8 544 0.162997 Q5T619 ZNF648 400 0.361564 Q14008 CKAP5 271 0.19395 P02647 APOA1 238 0.159222 P01023 A2M 230 0.131263 P10909 CLU 216 0.101279 P02786 TFRC 146 0.076278 P04275 VWF 146 0.093813 P02766 TTR 136...”
- Quantitative proteomic analysis for high-throughput screening of differential glycoproteins in hepatocellular carcinoma serum
Gao, Cancer biology & medicine 2015 - “...3.29 0.14 P02042 Hemoglobin subunit 8 278 2.94 1.35 Q5KTC1 SSF-TRPM2 2 4 2.81 0.84 Q5T619 Zinc finger protein 648 1 4 2.81 0.23 B4DVE1 Galectin-3-binding protein 3 12 2.71 0.73 Q59FC6 Tumor rejection antigen (Gp96) 1 variant 4 7 2.54 0.91 Q96JG9 Zinc finger protein...”
- “...87 OS=Homo sapiens GN=WDR87 PE=2 SV=3 - [WDR87_HUMAN] 0.24 2 1 1 2,873 333.0 7.28 Q5T619 Zinc finger protein 648 OS=Homo sapiens GN=ZNF648 PE=1 SV=1 - [ZN648_HUMAN] 2.11 1 1 1 568 62.3 8.62 B1AL55 EDAR-associated death domain (Fragment) OS=Homo sapiens GN=EDARADD PE=4 SV=1 - [B1AL55_HUMAN]...”
- Characterization and evolutionary origin of novel C2H2 zinc finger protein (ZNF648) required for both erythroid and megakaryocyte differentiation in humans.
Ferguson, Haematologica 2021 - GeneRIF: Characterization and evolutionary origin of novel C2H2 zinc finger protein (ZNF648) required for both erythroid and megakaryocyte differentiation in humans.
AO090003000678 No description from Aspergillus oryzae RIB40
44% identity, 9% coverage
- Forced Recycling of an AMA1-Based Genome-Editing Plasmid Allows for Efficient Multiple Gene Deletion/Integration in the Industrial Filamentous Fungus Aspergillus oryzae
Katayama, Applied and environmental microbiology 2019 - “...a transcription factor screen, we have previously identified AO090003000678 as a gene whose deletion leads to hyperproduction of sclerotia (H. Nakamura and J....”
- “...Maruyama, unpublished data). Since the orthologues of AO090003000678 are conserved in filamentous fungi, including Aspergillus fumigatus, of which Ace2 was...”
- Analysis of the Transcriptome in Aspergillus tamarii During Enzymatic Degradation of Sugarcane Bagasse
Midorikawa, Frontiers in bioengineering and biotechnology 2018 - “...transcription factor CreA (AO090026000464) (Ruijter and Visser, 1997 ), together with Ace1 (AO090005001502) and Ace2 (AO090003000678), whilst observed amongst the unigenes identified in the A. tamarii transcriptome, were not significantly differentially expressed on sugarcane bagasse in comparison to growth on glucose as carbon source. A total...”
LOC107437305 zinc finger protein ZIC 4-like from Parasteatoda tepidariorum
41% identity, 17% coverage
MAC_04654 Metallothionein expression activator from Metarhizium acridum
42% identity, 9% coverage
NP_001018479 Krueppel-like factor 7a from Danio rerio
46% identity, 25% coverage
- Krüpple-like factors 7 and 6a mRNA expression in adult zebrafish central nervous system.
Bhattarai, Gene expression patterns : GEP 2016 - GeneRIF: In the spinal cord, klf7- and klf6a-expressing cells are found in both the dorsal and ventral horns. Numerous sensory structures (e.g. auditory, lateral line, olfactory and visual) and several motor nuclei (e.g. oculomotor, trigeminal, and vagal motor nuclei) contain klf7- and/or klf6a-expressing cells
- Expression of ventral diencephalon-enriched genes in zebrafish.
Li, Developmental dynamics : an official publication of the American Association of Anatomists 2010 (PubMed)- GeneRIF: Data revealed that expression of DNA binding inhibitor 3, early B cell factor 2, Ebf3, Iroquois related homeobox 1, Kruppel-like factor 7 , mab-21-like 1 , fatty acid binding protein 7 and stathmin-like 4,were enriched in the diencephalon of zebrafish.
NP_524221 huckebein from Drosophila melanogaster
42% identity, 26% coverage
NP_001311268 zinc finger protein 354A isoform 2 from Homo sapiens
42% identity, 14% coverage
Z354A_HUMAN / O60765 Zinc finger protein 354A; Transcription factor 17; TCF-17; Zinc finger protein eZNF from Homo sapiens (Human) (see paper)
42% identity, 13% coverage
NP_991290 zinc finger protein ZIC 5 from Danio rerio
39% identity, 14% coverage
XP_040556013 zinc finger protein ZIC 3 from Gallus gallus
41% identity, 17% coverage
2i13B / Q07230 Aart, a six finger zinc finger designed to recognize ann triplets (see paper)
43% identity, 53% coverage
- Ligands: dna; zinc ion (2i13B)
ZN256_HUMAN / Q9Y2P7 Zinc finger protein 256; Bone marrow zinc finger 3; BMZF-3 from Homo sapiens (Human) (see paper)
43% identity, 12% coverage
- function: Transcriptional repressor that plays a role in cell proliferation. Requires TRIM28 for its activity.
subunit: Interacts with TRIM28. - Silencing of carbonic anhydrase I enhances the malignant potential of exosomes secreted by prostatic tumour cells
Bánová, Journal of cellular and molecular medicine 2019 - “...1.95 0.96 Xray repair crosscomplementing protein 5 OS=Homo sapiens GN=XRCC5 PE=1 SV=3 1029.18 2002.42 Nucleus Q9Y2P7 2 (1) 18.82 1.41E04 3.75 1.91 Zinc finger protein 256 OS=Homo sapiens GN=ZNF256 PE=4 SV=1 19.27 72.33 Nucleus Catalytic activity P43686 4 (4) 33.23 7.16E03 2.16 1.11 26S protease regulatory...”
Q96LW1 Zinc finger protein 354B from Homo sapiens
42% identity, 13% coverage
XP_011516617 zinc finger protein 782 isoform X1 from Homo sapiens
Q6ZMW2 Zinc finger protein 782 from Homo sapiens
43% identity, 11% coverage
XP_063119020 gonadotropin inducible ovarian transcription factor 1 isoform X1 from Rattus norvegicus
44% identity, 12% coverage
2i13A / Q07230 Aart, a six finger zinc finger designed to recognize ann triplets (see paper)
43% identity, 51% coverage
- Ligands: dna; glycerol; zinc ion (2i13A)
E9Q6Y4 Zinc finger protein 94 from Mus musculus
44% identity, 16% coverage
- Proteomic Analysis of Cardiac Adaptation to Exercise by High Resolution Mass Spectrometry
Al-Menhali, Frontiers in molecular biosciences 2021 - “...Ifi207 Interferon-activated gene 207 978 104.4 6 Q78Y63 Pdcl2 Phosducin-like protein 2 240 27.8 6 E9Q6Y4 Zfp94 Zinc finger protein 94 486 55.5 6 P51163 Uros Uroporphyrinogen-III synthase 265 28.5 6 P11352 Gpx1 Glutathione peroxidase 1 201 22.3 6 A2A432 Cul4b Cullin-4B 970 110.6 6 Q923D2...”
- Comparative proteomic analysis identifies age-dependent increases in the abundance of specific proteins after deletion of the small heat shock proteins αA- and αB-crystallin.
Andley, Biochemistry 2013 - “...factor HIVEP2, Q3UHF7 4 267 Myeloperoxidase, P11247 3 81 Alpha-2-macroglobulin, Q61838 2 166 Uncharacterized protein, E9Q6Y4 2 56 Protein S100-A6 P14069 2 10 1093 Spectrin 2, A3KG45 29 283 1.65 4.52 2.6 Titin, A2ASS6 5 3906 Catenin 1, Q02248 4 85 serrate RNA effector molecule homolog,...”
NP_033600 zinc finger protein ZIC 2 from Mus musculus
39% identity, 15% coverage
- SUMOylation Potentiates ZIC Protein Activity to Influence Murine Neural Crest Cell Specification.
Bellchambers, International journal of molecular sciences 2021 - GeneRIF: SUMOylation Potentiates ZIC Protein Activity to Influence Murine Neural Crest Cell Specification.
- Sox2 gene regulation via the D1 enhancer in embryonic neural tube and neural crest by the combined action of SOX2 and ZIC2.
Iida, Genes to cells : devoted to molecular & cellular mechanisms 2020 (PubMed)- GeneRIF: Sox2 gene regulation via the D1 enhancer in embryonic neural tube and neural crest by the combined action of SOX2 and ZIC2.
- Link between the causative genes of holoprosencephaly: Zic2 directly regulates Tgif1 expression.
Ishiguro, Scientific reports 2018 - GeneRIF: Loss of ZIC2 expression is associated with holoprosencephaly.
- Roles of ZIC2 in Regulation of Pluripotent Stem Cells.
Kondoh, Advances in experimental medicine and biology 2018 (PubMed)- GeneRIF: The major acting transcription factors shift from SOX2/POU5F1 in mouse ESCs to ZIC2/OTX2 in EpiSCs, and this shift is primed in ESCs by binding of ZIC2 at relevant genomic positions that later function as enhancers.
- Spina bifida-predisposing heterozygous mutations in Planar Cell Polarity genes and Zic2 reduce bone mass in young mice.
Orriss, Scientific reports 2018 - GeneRIF: Zic2 mutations significantly reduced trabecular bone mass and distal tibial cortical thickness.
- A Requirement for Zic2 in the Regulation of Nodal Expression Underlies the Establishment of Left-Sided Identity.
Dykes, Scientific reports 2018 - GeneRIF: ZIC2 is required for correct Nodal expression at the node and suggest a model in which ZIC2 acts at different levels to establish LR asymmetry, promoting both the production of the signal that induces left side identity and the morphogenesis of the cilia that bias its distribution.
- ChIP-seq analysis of genomic binding regions of five major transcription factors highlights a central role for ZIC2 in the mouse epiblast stem cell gene regulatory network.
Matsuda, Development (Cambridge, England) 2017 - GeneRIF: This shift in the major acting transcription factors appears to be primed by binding of ZIC2 in embryonic stem cells at relevant genomic positions.
- Zic-Proteins Are Repressors of Dopaminergic Forebrain Fate in Mice and C. elegans.
Tiveron, The Journal of neuroscience : the official journal of the Society for Neuroscience 2017 - GeneRIF: Zic2 and Zic1 proteins are essential to control the balance between two defined neuron types in the postnatal forebrain.
- More
ZIC2_MOUSE / Q62520 Zinc finger protein ZIC 2; Zinc finger protein of the cerebellum 2 from Mus musculus (Mouse) (see 12 papers)
39% identity, 15% coverage
- function: Acts as a transcriptional activator or repressor. Plays important roles in the early stage of organogenesis of the CNS. Activates the transcription of the serotonin transporter SERT in uncrossed ipsilateral retinal ganglion cells (iRGCs) to refine eye- specific projections in primary visual targets. Its transcriptional activity is repressed by MDFIC. Involved in the formation of the ipsilateral retinal projection at the optic chiasm midline. Drives the expression of EPHB1 on ipsilaterally projecting growth cones. Binds to the minimal GLI-consensus sequence 5'-TGGGTGGTC-3'. Associates to the basal SERT promoter region from ventrotemporal retinal segments of retinal embryos.
subunit: Interacts with RNF180 (PubMed:18363970). Interacts (via the C2H2-type domains 3, 4 and 5) with MDFIC (via the C2H2-type domains 3, 4 and 5); the interaction reduces its transcriptional activity (PubMed:15207726, PubMed:15465018). Interacts (via C2H2-type domain 3) with DHX9 (PubMed:18068128). Interacts with GLI1 and GLI2 (PubMed:11238441).
disruption phenotype: Mice show impaired dorsal forebrain development and insufficient closure of the posterior neuropore. Mice survive with holoprosencephaly (HPE) and spina bifida.
NP_033594 zinc finger protein 45 isoform 2 from Mus musculus
44% identity, 16% coverage
NP_571633 zinc finger protein ZIC 2a from Danio rerio
39% identity, 17% coverage
- Comparative sequence analysis and functional validation identified a retina-specific enhancer around zic5 and zic2a.
Zhang, Gene expression patterns : GEP 2021 (PubMed)- GeneRIF: Comparative sequence analysis and functional validation identified a retina-specific enhancer around zic5 and zic2a.
- Zebrafish zic2 controls formation of periocular neural crest and choroid fissure morphogenesis.
Sedykh, Developmental biology 2017 - GeneRIF: these data establish zic2 mutant zebrafish as a powerful new genetic model for in-depth dissection of cell interactions and genetic controls during craniofacial complex development.
- Zebrafish Zic2a and Zic2b regulate neural crest and craniofacial development.
Teslaa, Developmental biology 2013 - GeneRIF: Zic2a and Zic2b play a dual role during craniofacial development, in neural crest induction and migration, and in craniofacial chondrogenesis patterning
- A novel genetic mechanism regulates dorsolateral hinge-point formation during zebrafish cranial neurulation.
Nyholm, Journal of cell science 2009 - GeneRIF: Zic2a and zic5 as crucial players in the genetic network linking patterned gene expression to morphogenetic changes during neurulation.
- Zebrafish zic2a patterns the forebrain through modulation of Hedgehog-activated gene expression.
Sanek, Development (Cambridge, England) 2009 - GeneRIF: These data uncover a novel, essential role for Zic2a as a modulator of Hedgehog-activated gene expression in the developing forebrain
- A novel role for zebrafish zic2a during forebrain development.
Sanek, Developmental biology 2008 - GeneRIF: the results identify Zic2a as a novel regulator of prethalamic development, and show that it functions independently of hedgehog signaling.
- The zebrafish zic2a-zic5 gene pair acts downstream of canonical Wnt signaling to control cell proliferation in the developing tectum.
Nyholm, Development (Cambridge, England) 2007 (PubMed)- GeneRIF: Zic2a and Zic5 have essential, cooperative roles in promoting cell proliferation in the tectum, but lack obvious patterning functions.
Smp_068240 putative zinc finger protein from Schistosoma mansoni
41% identity, 14% coverage
KLF1_DANRE / Q90XE6 Kruppel-like factor 1; Erythroid krueppel-like transcription factor; Kruppel-like factor d from Danio rerio (Zebrafish) (Brachydanio rerio) (see 3 papers)
NP_571011 Kruppel-like factor 1 from Danio rerio
43% identity, 20% coverage
- function: Transcription regulator (PubMed:18941117, PubMed:33833125). Plays a role in erythropoiesis, binding to promoters and activating transcription of embryonic alpha globin e1 hbae1.1 and microRNA mir- 144, in erythroid progenitors; perhaps acting as part of a negative feedback loop with mir-144 (PubMed:18941117, PubMed:33833125). May coordinate repression of genes controlling myocardial differentiation and mitochondrial metabolism with positive modulation of cell proliferation genes (PubMed:33833125). Required for regeneration of the myocardium after injury, probably acting by stimulating renewal of preexisting cardiomyocytes in adult hearts (PubMed:33833125).
disruption phenotype: Morpholino knockdown causes significant reduction in expression of embryonic alpha globin e1 hbae1.1 in 22 hpf (hours post fertilization) and 36 hpf embryos. - Cooperative contributions of the klf1 and klf17 genes in zebrafish primitive erythropoiesis.
Suzuki, Scientific reports 2023 - GeneRIF: Cooperative contributions of the klf1 and klf17 genes in zebrafish primitive erythropoiesis.
- Krüppel-like factor 1 is a core cardiomyogenic trigger in zebrafish.
Ogawa, Science (New York, N.Y.) 2021 (PubMed)- GeneRIF: Kruppel-like factor 1 is a core cardiomyogenic trigger in zebrafish.
NP_476601 worniu from Drosophila melanogaster
40% identity, 14% coverage
- Drosophila Neuroblast Selection Is Gated by Notch, Snail, SoxB, and EMT Gene Interplay.
Arefin, Cell reports 2019 (PubMed)- GeneRIF: Drosophila Neuroblast Selection Is Gated by Notch, Snail, SoxB, and EMT Gene Interplay.
- The Snail family member Worniu is continuously required in neuroblasts to prevent Elav-induced premature differentiation.
Lai, Developmental cell 2012 - GeneRIF: The Worniu is continuously required in neuroblasts to maintain self-renewal by promoting cell-cycle progression and inhibiting premature differentiation.
- A survey of well conserved families of C2H2 zinc-finger genes in Daphnia
Seetharam, BMC genomics 2010 - “...(NP_499902) Dappu- 53927 39:954341-955431 SNAIL2 (O43623) ESG (P25932) SCRT1(NP_491001) Dappu- 129982 110:193847-194734 SNAIL1 (O95863) WOR (NP_476601) CES1 (NP_492338) ESG (Dappu-347447) 23:1247838-1249532 hSCRT1 (Q9BWW7) SCRT (Q24140) Dappu- 61957 110:238640-239641 hSCRT2 (Q9NQ03) CG12605 (NP_995996) CG12391 (NP_610639) CG17181 (NP_612040) GLI GLI1 (P08151) CI (P19538) TRA1(NP_001022880) CI (Dappu-346973) 3:880659-885822 GLI2...”
- The repressor function of snail is required for Drosophila gastrulation and is not replaceable by Escargot or Worniu.
Hemavathy, Developmental biology 2004 (PubMed)- GeneRIF: snail is required for Drosophila gastrulation and is not replaceable by Escargot or Worniu.
- Worniu, a Snail family zinc-finger protein, is required for brain development in Drosophila.
Ashraf, Developmental dynamics : an official publication of the American Association of Anatomists 2004 (PubMed)- GeneRIF: Results suggest that the loss of Worniu function within the neuroblasts ultimately causes the larval brainstem to fail to go through shortening during development.
ZIC2_HUMAN / O95409 Zinc finger protein ZIC 2; Zinc finger protein of the cerebellum 2 from Homo sapiens (Human) (see 6 papers)
NP_009060 zinc finger protein ZIC 2 from Homo sapiens
39% identity, 14% coverage
- function: Acts as a transcriptional activator or repressor. Plays important roles in the early stage of organogenesis of the CNS. Activates the transcription of the serotonin transporter SERT in uncrossed ipsilateral retinal ganglion cells (iRGCs) to refine eye- specific projections in primary visual targets. Its transcriptional activity is repressed by MDFIC. Involved in the formation of the ipsilateral retinal projection at the optic chiasm midline. Drives the expression of EPHB1 on ipsilaterally projecting growth cones. Binds to the minimal GLI-consensus sequence 5'-TGGGTGGTC-3'. Associates to the basal SERT promoter region from ventrotemporal retinal segments of retinal embryos
subunit: Interacts with RNF180. Interacts (via the C2H2-type domains 3, 4 and 5) with MDFIC (via the C2H2-type domains 3, 4 and 5); the interaction reduces its transcriptional activity. Interacts with GLI1 and GLI2 (By similarity). Interacts (via C2H2-type domain 3) with DHX9 (PubMed:17251188). - Transcription factor ZIC2 regulates the tumorigenic phenotypes associated with both bulk and cancer stem cells in epithelial ovarian cancer.
Chen, Oncogene 2024 (PubMed)- GeneRIF: Transcription factor ZIC2 regulates the tumorigenic phenotypes associated with both bulk and cancer stem cells in epithelial ovarian cancer.
- ZIC2 and ZIC3 promote SWI/SNF recruitment to safeguard progression towards human primed pluripotency.
Hossain, Nature communications 2024 - GeneRIF: ZIC2 and ZIC3 promote SWI/SNF recruitment to safeguard progression towards human primed pluripotency.
- ZIC2 induces pro-tumor macrophage polarization in nasopharyngeal carcinoma by activating the JUNB/MCSF axis.
Liu, Cell death & disease 2023 - GeneRIF: ZIC2 induces pro-tumor macrophage polarization in nasopharyngeal carcinoma by activating the JUNB/MCSF axis.
- FOXM1-regulated ZIC2 promotes the malignant phenotype of renal clear cell carcinoma by activating UBE2C/mTOR signaling pathway.
Lv, International journal of biological sciences 2023 - GeneRIF: FOXM1-regulated ZIC2 promotes the malignant phenotype of renal clear cell carcinoma by activating UBE2C/mTOR signaling pathway.
- ZIC2 accelerates growth and stemness in gastric cancer through the Wnt/β-catenin pathway.
Yu, Tissue & cell 2023 (PubMed)- GeneRIF: ZIC2 accelerates growth and stemness in gastric cancer through the Wnt/beta-catenin pathway.
- ZIC2 promotes colorectal cancer growth and metastasis through the TGF-β signaling pathway.
Liu, Experimental cell research 2022 (PubMed)- GeneRIF: ZIC2 promotes colorectal cancer growth and metastasis through the TGF-beta signaling pathway.
- The tumor-suppressive role of microRNA-873 in nasopharyngeal carcinoma correlates with downregulation of ZIC2 and inhibition of AKT signaling pathway.
Lv, Cancer gene therapy 2021 (PubMed)- GeneRIF: The tumor-suppressive role of microRNA-873 in nasopharyngeal carcinoma correlates with downregulation of ZIC2 and inhibition of AKT signaling pathway.
- Correlation of zinc finger protein 2, a prognostic biomarker, with immune infiltrates in liver cancer.
Sun, Bioscience reports 2021 - GeneRIF: Correlation of zinc finger protein 2, a prognostic biomarker, with immune infiltrates in liver cancer.
- More
- Structure analysis of the proteins associated with polyA repeat expansion disorders.
Hernandez, Journal of biomolecular structure & dynamics 2022 - “...(Tract 1) P41225 15 22 XH; (OMIM #300123) SOX3 (Tract 2) P41225 7 26 ZIC2 O95409 9 19 HPE5; (OMIM #609637) 1 WTTL : Wild Type Tract Length. 2 MPTL : Minimum Pathological Tract Length. 3 For details of the disease nomenclature, see Ref. ( 16...”
- Brain and testis: more alike than previously thought?
Matos, Open biology 2021 - “...1 brain development ; cell fate specification; regulation of axon guidance ; regulation of transcription O95409 ZIC2 zinc finger protein ZIC 2 brain development ; cell differentiation; positive regulation of transcription O96T25 ZIC5 zinc finger protein ZIC 5 cell differentiation; CNS development 2.3 . Why do...”
- Brainstem Organoids From Human Pluripotent Stem Cells.
Eura, Frontiers in neuroscience 2020 - “...HIST3H2BB Q8N257 4.40083852 1.304593593 19.49310574 0.0000101 0.00020181 HELLS Q9NRZ9 2.112404374 6.517273007 12.01916385 0.000526563 0.004961459 ZIC2 O95409 1.958589485 3.966265294 7.992220317 0.004697877 0.026045008 Cerebellum, midbrain, pons, medulla MAB21L1 Q13394 3.26983685 1.866012194 13.63006394 0.000222592 0.002412928 Basal ganglia PCP4 P48539 2.607799879 3.661385349 10.15879101 0.001436148 0.010890787 To assess the electrical functionality...”
- Intrinsic Disorder in Proteins with Pathogenic Repeat Expansions
Darling, Molecules (Basel, Switzerland) 2017 - “...manner related to intramembranous bone ossification [ 243 ]. Zinc finger protein ZIC2 (UniProt ID: O95409) has a MobiDB-defined disorder content of 54.89%. Figure 2 D and Figure S1D illustrate that this protein has long IDPRs located in its N- and C-terminal tails. The protein is...”
- “...factor 2, RUNX2 (UniProt ID: Q13950); ( D ) Zinc finger protein ZIC2 (UniProt ID: O95409); ( E ) Paired mesoderm homeobox protein 2B (UniProt ID: Q99453); ( F ) Transcription factor SOX3 (UniProt ID: P41225); ( G ) Homeobox protein ARX (UniProt ID: Q96QS3); (...”
- Trinucleotide repeats: a structural perspective.
Almeida, Frontiers in neurology 2013 - “...No structural information Holoprosencephaly (ZIC2) GCG Protein coding region (polyA) ZIC2 Zinc-finger protein ZIC 2 (O95409, 532 residues) Differentiation, neurogenesis, transcription, transcription regulation 15 25 No structural information Hand-Foot-Genital Syndrome/HOXA13) GCG Protein coding region (polyA) HOXA13 homeobox A13 (P31271, 388 residues) Transcription, transcription regulation 18 2426...”
- A survey of well conserved families of C2H2 zinc-finger genes in Daphnia
Seetharam, BMC genomics 2010 - “...CG31835 (NP_723881) CG15286 (NP_609706) ZIC ZIC1 (Q15915) OPA (P39768) REF2 (Q94178) OPA (Dappu-290567) 104:131019-135418 ZIC2 (O95409) SUG (Q7K0S9) ZIC3 (O60481) ZIC4(Q8N9L1) ZIC5(Q96T25) OVO OVOL1 (O14753) OVOrb (P51521) LIN48 (Q19996) OVO (Dappu-290491) 191:57-1323 OVOL2 (Q9BRP0) SNAIL SNAIL3 (NP_840101) SNAIL (P08044) K02D7 (NP_499902) Dappu- 53927 39:954341-955431 SNAIL2 (O43623)...”
XP_009475765 zinc finger protein SNAI3 from Nipponia nippon
45% identity, 36% coverage
- Potential Involvement of Snail Members in Neuronal Survival and Astrocytic Migration during the Gecko Spinal Cord Regeneration
Shen, Frontiers in cellular neuroscience 2017 - “...vexillifer Snail1 (XP_007446447), Snail2 (XP_007464078), Snail3 (XP_007468498); bird Nipponia nippon Snail1 (XP_009463837), Snail2 (XP_009471359), Snail3 (XP_009475765); bird Haliaeetus leucocephalus Snail1 (XP_010567958), Snail2 (XP_010572691), Snail3 (XP_010578013); bird Serinus canaria Snail1 (XP_009091543), Snail2 (XP_009101147); green anole Anolis carolinensis Snail1 (XP_003220701), Snail2 (XP_003223554), Snail3 (XP_003228606); turtle Pelodiscus sinensis Snail2...”
A8KAD2 cDNA FLJ77477, highly similar to Homo sapiens zinc finger protein 484 (ZNF484), transcript variant 2, mRNA from Homo sapiens
44% identity, 9% coverage
8e3eF / O95365 Zbtb7a zinc finger domain bound to DNA duplex containing cast sequence (#10) (see paper)
47% identity, 64% coverage
- Ligands: dna; zinc ion (8e3eF)
CG42741, NP_611747 uncharacterized protein from Drosophila melanogaster
43% identity, 21% coverage
- Natural variation in the regulation of neurodevelopmental genes modifies flight performance in Drosophila
Spierer, PLoS genetics 2021 - “...variants that mapped to several intergenic variants and six genes ( CG6123 , CG7573 , CG42741 , ppk23 , Src64B , twi ). Most notably, four variants mapped to a 1,002 bp region downstream of pickpocket 23 ( ppk23 ; human homologs in ASIC gene family)...”
- “...( Art2 , CG10936 , CG15630 , CG15651 , CG18507 , CG3921 , CG42671 , CG42741 , CG5645 , CG6123 , CG9313 , CR44176 , cv-c , Fad2 , natalisin , ppk23 , Rbfox1 , Rgk1 , Src64B , twi ; Fig 4A ). Of the...”
- Natural genetic variation in Drosophila melanogaster reveals genes associated with Coxiella burnetii infection
Guzman, Genetics 2021 - “...synonymous 6.1 10 -6 Male 1.5 Euchromatin transcriptionally silent or dynamic Beta 1,3-glucan recognition/binding CRYBG1 CG42741 2R_18904195_SNP Intronic 5.3 10 -6 Difference 10 Transcriptionally silent Zinc finger C2H2 transcription factor KLF3 trh 3L_376337_SNP Intronic 4.4 10 -7 Difference 2.6 TFBS bHLH-PAS transcription factor NPAS1 CG32264 3L_3750617_SNP...”
- “...definite cause. Validating genes from the difference category have higher differential sex expression, such as CG42741 and CG42673 , which are 10 and 4.5-times more expressed in males than females, respectively. In contrast, validating genes in average category have closer relative expression, such as Pura and...”
- Gene activation by dCas9-CBP and the SAM system differ in target preference
Sajwan, Scientific reports 2019 - “...flank the silent loci that are activated by promoter-bound dCas9-CBP. This showed that expression of CG42741 that is located 3.2kb from the twi transcription start site (TSS) could be weakly activated by dCas9-CBP bound to the twi promoter (Fig. 3A ). CG42741 is poorly expressed in...”
- “...S4 ). Figure 3 Promoter-bound dCas9-CBP and SAM can activate nearby genes. ( A ) CG42741 and Fatp2 expression in S2 cells transfected with dCas9 fusions and control or gRNA targeting the twi promoter (same as in Fig. 1B ). ( B ) Expression of invected...”
- Correction: Genome-Wide Association Study on Male Genital Shape and Size in Drosophila melanogaster
Takahara, PloS one 2018 - “...CG4770 Sec13 RpS3 X RunxB PC2 2L Hel25E 2R Obp58d Obp58c CR43735 CD30275 CG42260 twi CG42741 CG13197 3L unc-13-4A 3R CG5404 Osi17 Q3 X hang Size 2L CG31933 CG31664 2R HLH54F 3L CG43693 Q2 Nrx-IV Q2 CAH2 Q2 bru-3 CG17145 Q3 cdi Reference 1 Takahara B...”
- A comparison of nucleosome organization in Drosophila cell lines
Martin, PloS one 2017 - “...GGGGGGA AGGGGGG ACCCCCC CCCACCC CCCCCCA CACCCCC CCACCCC CCCCCGC CACCCCC CG3065 CCCCGCC CGCGCCC GCCCCCC CACCCCC CCACCCC CG42741 CCCCGCC Crol CCCCGCC CCCCCCC GGGGGGA AGGGGGG CCCTCCC CCTCCCC ACCCCCC CACCCCC Hnf4 CCCCGCC Lmd CCCCGCC CCCCCCC ACCCCCC CCCCCCA GCCCCCC CCCCCCG CCCCCGC CACCCCC Luna CCCCGCC Opa CCCCGCC CCCCCCC GGGGGGA ACCCCCC CCCCCCA GCCCCCC...”
- KLF/SP Transcription Factor Family Evolution: Expansion, Diversification, and Innovation in Eukaryotes
Presnell, Genome biology and evolution 2015 - “...0.95; fig. 2 ). Notably, the Drosophila KLF sequence that contains a PVDLS domain ( CG42741 ) falls outside of the KLF3/8/12 clade which consists exclusively of vertebrate sequences. Within this clade the KLF8 orthologs are recovered with BPP = 1. Despite poor annotation in the...”
- “...in vertebrate KLFs defining the 3/8/12 architecture group and in a lone Drosophila KLF ( CG42741 ). Our phylogenetic analyses suggest, however, that the fly sequence is not nested within the highly supported KLF3/8/12 clade ( supplementary figs. S2 and S3 , Supplementary Material online). To...”
- C2H2 zinc finger proteins of the SP/KLF, Wilms tumor, EGR, Huckebein, and Klumpfuss families in metazoans and beyond
Pei, Gene 2015 - “...The model organism Drosophila melanogaster of the Ecdysozoa group has only five KLF proteins (KLFB: CG42741, KLFC: dar1, KLFD: luna, KLFF: cabut, and KLFG: bteb2) and lacks KLFA and KLFE. The other surveyed insect species, Tribolium castaneum ( Tribolium Genome Sequencing et al. 2008 ), has...”
- A survey of well conserved families of C2H2 zinc-finger genes in Daphnia
Seetharam, BMC genomics 2010 - “...SP8 (Q8IXZ3) KLF KLF1 (Q13351) CG12029 (NP_647822) KLF1 (NP_497632) KLF1A (Dappu-48391) scaffold_16:1551074-1551469 KLF2 (Q9Y5W3) CG9895 (NP_611747) F53F8.1 (NP_507995) KLF1B (Dappu-51551) scaffold_26:196741-197325 KLF3 (P57682) CG3065 (NP_726393) MUA1 (AAU20846) KLF1C (Dappu-243802) scaffold_26:237754-238940 KLF4 (O43474) CABUT (NP_608529) KLF1D (Dappu-262353) scaffold_168:128271-129531 KLF5 (Q13887) LUNA (NP_995811) KLF3 (Dappu-27999) scaffold_1:1214746-1215144 KLF6 (Q99612)...”
XP_021701249 Krueppel homolog 1 isoform X2 from Aedes aegypti
48% identity, 9% coverage
F1LX23 Zinc finger protein 267 from Rattus norvegicus
45% identity, 9% coverage
- DPCfam: Unsupervised protein family classification by Density Peak Clustering of large sequence datasets.
Russo, PLoS computational biology 2022 - “...seed sequences carries a Pfam annotation. A) MC and Pfam family architecture of DNA-binding protein F1LX23, a representative of seed sequence of MC12287. The thin black like represents the full length protein sequence. Boxes above the sequence represent DPCfam MC annotations: MC434132 from aa 22 to...”
- “...(the image is generated by the DPCfam website, https://dpcfam.areasciencepark.it/ ). B) Three-dimensional structure of protein F1LX23 as predicted by AlphaFold2 (Cramer, Patrick. AlphaFold2 and the future of structural biology. Nature Structural & Molecular Biology 28(9) (2021): 704705.). Colors indicate where DPCfam annotations map onto the protein...”
ZN300_HUMAN / Q96RE9 Zinc finger protein 300 from Homo sapiens (Human) (see 3 papers)
40% identity, 13% coverage
- function: Has a transcriptional repressor activity.
subunit: Interacts (via the KRAB domain) with TRIM28 (via the RBCC domain). - Data on the impact of the blood sample collection methods on blood protein profiling studies.
Ilies, Data in brief 2017 - “...0.17 P24043 LAMA2 Laminin subunit alpha-2 Secreted 11392 12288 14534 17688 16610 15376 14648 0.17 Q96RE9 ZN300 Zinc finger protein 300 Leakage 7134 11365 11937 20051 15033 15472 13499 0.33 Q9P0W5 SCHI1 Schwannomin-interacting protein 1 Leakage 17022 10273 10231 14051 10710 10656 12157 0.23 Q5RL73 RBM48...”
ZBT7A_HUMAN / O95365 Zinc finger and BTB domain-containing protein 7A; Factor binding IST protein 1; FBI-1; Factor that binds to inducer of short transcripts protein 1; HIV-1 1st-binding protein 1; Leukemia/lymphoma-related factor; POZ and Krueppel erythroid myeloid ontogenic factor; POK erythroid myeloid ontogenic factor; Pokemon; Pokemon 1; TTF-I-interacting peptide 21; TIP21; Zinc finger protein 857A from Homo sapiens (Human) (see 15 papers)
NP_056982 zinc finger and BTB domain-containing protein 7A from Homo sapiens
47% identity, 13% coverage
- function: Transcription factor that represses the transcription of a wide range of genes involved in cell proliferation and differentiation (PubMed:14701838, PubMed:17595526, PubMed:20812024, PubMed:25514493, PubMed:26455326, PubMed:26816381). Directly and specifically binds to the consensus sequence 5'-[GA][CA]GACCCCCCCCC-3' and represses transcription both by regulating the organization of chromatin and through the direct recruitment of transcription factors to gene regulatory regions (PubMed:12004059, PubMed:17595526, PubMed:20812024, PubMed:25514493, PubMed:26816381). Negatively regulates SMAD4 transcriptional activity in the TGF-beta signaling pathway through these two mechanisms (PubMed:25514493). That is, recruits the chromatin regulator HDAC1 to the SMAD4-DNA complex and in parallel prevents the recruitment of the transcriptional activators CREBBP and EP300 (PubMed:25514493). Collaborates with transcription factors like RELA to modify the accessibility of gene transcription regulatory regions to secondary transcription factors (By similarity). Also directly interacts with transcription factors like SP1 to prevent their binding to DNA (PubMed:12004059). Functions as an androgen receptor/AR transcriptional corepressor by recruiting NCOR1 and NCOR2 to the androgen response elements/ARE on target genes (PubMed:20812024). Thereby, negatively regulates androgen receptor signaling and androgen- induced cell proliferation (PubMed:20812024). Involved in the switch between fetal and adult globin expression during erythroid cells maturation (PubMed:26816381). Through its interaction with the NuRD complex regulates chromatin at the fetal globin genes to repress their transcription (PubMed:26816381). Specifically represses the transcription of the tumor suppressor ARF isoform from the CDKN2A gene (By similarity). Efficiently abrogates E2F1-dependent CDKN2A transactivation (By similarity). Regulates chondrogenesis through the transcriptional repression of specific genes via a mechanism that also requires histone deacetylation (By similarity). Regulates cell proliferation through the transcriptional regulation of genes involved in glycolysis (PubMed:26455326). Involved in adipogenesis through the regulation of genes involved in adipocyte differentiation (PubMed:14701838). Plays a key role in the differentiation of lymphoid progenitors into B and T lineages (By similarity). Promotes differentiation towards the B lineage by inhibiting the T-cell instructive Notch signaling pathway through the specific transcriptional repression of Notch downstream target genes (By similarity). Also regulates osteoclast differentiation (By similarity). May also play a role, independently of its transcriptional activity, in double-strand break repair via classical non-homologous end joining/cNHEJ (By similarity). Recruited to double-strand break sites on damage DNA, interacts with the DNA-dependent protein kinase complex and directly regulates its stability and activity in DNA repair (By similarity). May also modulate the splicing activity of KHDRBS1 toward BCL2L1 in a mechanism which is histone deacetylase-dependent and thereby negatively regulates the pro-apoptotic effect of KHDRBS1 (PubMed:24514149).
subunit: Homodimer (PubMed:9973611). Interacts with BCL6 (By similarity). Interacts with RELA; involved in the control by RELA of the accessibility of target gene promoters (PubMed:29813070). Interacts with AR (via NR LBD domain); the interaction is direct and androgen- dependent (PubMed:20812024). Interacts with NCOR1 (PubMed:20812024). Interacts with NCOR2 (PubMed:20812024). Interacts with SMAD4; the interaction is direct and stimulated by TGFB1 (PubMed:25514493). Interacts with HDAC1 (PubMed:25514493). Interacts with SP1; ZBTB7A prevents the binding to GC-rich motifs in promoters and represses the transcriptional activity of SP1 (PubMed:12004059). Interacts with the DNA-dependent protein kinase complex/DNA-PKc (PubMed:26446488). Interacts with KHDRBS1; negatively regulates KHDRBS1 splicing activity (PubMed:24514149). - Proteomic analysis of holocarboxylase synthetase deficient-MDA-MB-231 breast cancer cells revealed the biochemical changes associated with cell death, impaired growth signaling, and metabolism.
Sukjoi, Frontiers in molecular biosciences 2023 - “...subunit 29 1.7 3.0 1.1 1.6 O60907 TBL1X F-box-like/WD repeat-containing protein 2.6 7.4 1.2 1.8 O95365 ZBTB7A Zinc finger and BTB domain-containing protein 7A 1.2 1.5 1.6 2.5 Q16594 TAF9 Transcription initiation factor TFIID subunit 9 1.7 2.6 3.1 14.9 Q5JXX2 MORF4L2 Mortality factor 4-like protein...”
- Non-thermal plasma modulates cellular markers associated with immunogenicity in a model of latent HIV-1 infection.
Mohamed, PloS one 2021 - “...P35269 T2FA 0.42 HLA-A0301 HVIKPVLP Q13395 TARB1 0.02 HLA-A0301 EQLMGAVVM Q9UN37 VPS4A 1.2 HLA-B3501 DATKEAVAA O95365 ZBT7A 1.98 HLA-B3501 Discussion ART has been very successful in reducing the burden of HIV infection and prolonging the lives of HIV-1 infected subjects, but is associated with serious side...”
- dagLogo: An R/Bioconductor package for identifying and visualizing differential amino acid group usage in proteomics data.
Ou, PloS one 2020 - “...to their current UniProt Swiss-Prot IDs; and iii) six substrates without current Swiss-Prot records (O55106, O95365, P78559, Q00839, Q06210 and Q149F1) were removed. These manipulations resulted in 416 human protein substrates of the human GRB for the case study. The processed data are included as S3...”
- Functionally Annotating Regulatory Elements in the Equine Genome Using Histone Mark ChIP-Seq.
Kingsley, Genes 2019 - “...8 Q92731 4 Zfx SSSGCCBVGGCCTS 1.44 10 8 P17010 5 ZBTB7A NVCCGGAAGTGSV 1.46 10 8 O95365 6 TFAP2A(var.2) YGCCCBVRGGCR 6.51 10 8 P05549 Muscle 1 SP1 GCCCCKCCCCC 1.45 10 9 P08047 2 SP2 GYCCCGCCYCYBSSS 4.21 10 9 Q02086 3 SP8 RCCACGCCCMCY 1.15 10 8 Q8IXZ3 4...”
- Defining the human C2H2 zinc finger degrome targeted by thalidomide analogs through CRBN.
Sievers, Science (New York, N.Y.) 2018 - “...DDB1 (Uniprot entry Q16531), CRBN (Q96SW2), IKZF1 (Q13422), ZNF692 (Q9BU19), BCL6 (P41182), BCL6B (Q8N143), ZBT7A (O95365), ZBT7B (O15156), GZF1 (Q9H116), ZBT16 (Q05516), HIC1 (Q14526), HIC2 (Q96JB3), WIZ (O95785), SALL1 (Q9NSC2), SALL2 (Q9Y467), SALL3 (Q9BXA9), SALL4 (Q9UJQ4), EGR1 (P18146), EGR4 (Q05215), OSR1 (Q8TAX0) and OSR2 (Q8N2R0) were...”
- Probing the efficiency of proteolytic events by positional proteomics.
Plasman, Molecular & cellular proteomics : MCP 2011 - Complementary quantitative proteomics reveals that transcription factor AP-4 mediates E-box-dependent complex formation for transcriptional repression of HDM2
Ku, Molecular & cellular proteomics : MCP 2009 - “...RAD50 153797 N/A N/A N/A 83 4 1.96 0.27 1.81 0.25 O95365 ZBTB7A 61401 886 15 5.66 1.90 56 2 3.32 0.26 3.09 0.17 Q13363 O95785 P49711 Q9NZI6 CTBP1 WIZ CTCF...”
- Pokemon inhibits Bim transcription to promote the proliferation, anti-anoikis, invasion, histological grade, and dukes stage of colorectal neoplasms.
Wang, Journal of cancer research and clinical oncology 2024 - GeneRIF: Pokemon inhibits Bim transcription to promote the proliferation, anti-anoikis, invasion, histological grade, and dukes stage of colorectal neoplasms.
- ZBTB7A forms a heterodimer with ZBTB2 and inhibits ZBTB2 homodimerization required for full activation of HIF-1.
Kambe, Biochemical and biophysical research communications 2024 (PubMed)- GeneRIF: ZBTB7A forms a heterodimer with ZBTB2 and inhibits ZBTB2 homodimerization required for full activation of HIF-1.
- Microcribriform Adenocarcinoma of Salivary Glands: A Unique Tumor Entity Characterized by an SS18::ZBTB7A Fusion.
Weinreb, The American journal of surgical pathology 2023 (PubMed)- GeneRIF: Microcribriform Adenocarcinoma of Salivary Glands: A Unique Tumor Entity Characterized by an SS18::ZBTB7A Fusion.
- ZBTB7A suppresses glioblastoma tumorigenesis through the transcriptional repression of EPB41L5.
Jeong, Experimental & molecular medicine 2023 - GeneRIF: ZBTB7A suppresses glioblastoma tumorigenesis through the transcriptional repression of EPB41L5.
- Structural basis for transcription factor ZBTB7A recognition of DNA and effects of ZBTB7A somatic mutations that occur in human acute myeloid leukemia.
Ren, The Journal of biological chemistry 2023 - GeneRIF: Structural basis for transcription factor ZBTB7A recognition of DNA and effects of ZBTB7A somatic mutations that occur in human acute myeloid leukemia.
- Post-translational regulation of proto-oncogene ZBTB7A expression by p53 status in cancer cells: HSP90-dependent stabilization vs. p53-KLHL20-ubiquitin proteasomal degradation.
Choi, Biochimica et biophysica acta. Gene regulatory mechanisms 2023 (PubMed)- GeneRIF: Post-translational regulation of proto-oncogene ZBTB7A expression by p53 status in cancer cells: HSP90-dependent stabilization vs. p53-KLHL20-ubiquitin proteasomal degradation.
- ZBTB7A as a novel vulnerability in neuroendocrine prostate cancer.
Bae, Frontiers in endocrinology 2023 - GeneRIF: ZBTB7A as a novel vulnerability in neuroendocrine prostate cancer.
- Targeting Pokemon is a novel strategy to suppress cancer aggressiveness of non-small cell lung cancer: Identification of Pokemon as ideal target for developing anti-NSCLC drugs.
Chang, Archives of biochemistry and biophysics 2023 (PubMed)- GeneRIF: Targeting Pokemon is a novel strategy to suppress cancer aggressiveness of non-small cell lung cancer: Identification of Pokemon as ideal target for developing anti-NSCLC drugs.
- More
ZBT7A_MOUSE / O88939 Zinc finger and BTB domain-containing protein 7A; Leukemia/lymphoma-related factor; POZ and Krueppel erythroid myeloid ontogenic factor; POK erythroid myeloid ontogenic factor; Pokemon from Mus musculus (Mouse) (see 8 papers)
47% identity, 14% coverage
- function: Transcription factor that represses the transcription of a wide range of genes involved in cell proliferation and differentiation (PubMed:15337766, PubMed:15662416, PubMed:17495164, PubMed:26816381, PubMed:29813070). Directly and specifically binds to the consensus sequence 5'-[GA][CA]GACCCCCCCCC-3' and represses transcription both by regulating the organization of chromatin and through the direct recruitment of transcription factors to gene regulatory regions (PubMed:15337766, PubMed:15662416, PubMed:26816381, PubMed:29813070). Negatively regulates SMAD4 transcriptional activity in the TGF-beta signaling pathway through these two mechanisms (By similarity). That is, recruits the chromatin regulator HDAC1 to the SMAD4-DNA complex and in parallel prevents the recruitment of the transcriptional activators CREBBP and EP300 (By similarity). Collaborates with transcription factors like RELA to modify the accessibility of gene transcription regulatory regions to secondary transcription factors (PubMed:29813070). Also directly interacts with transcription factors like SP1 to prevent their binding to DNA (By similarity). Functions as an androgen receptor/AR transcriptional corepressor by recruiting NCOR1 and NCOR2 to the androgen response elements/ARE on target genes (By similarity). Thereby, negatively regulates androgen receptor signaling and androgen-induced cell proliferation (By similarity). Involved in the switch between fetal and adult globin expression during erythroid cells maturation (PubMed:26816381). Through its interaction with the NuRD complex regulates chromatin at the fetal globin genes to repress their transcription (PubMed:26816381). Specifically represses the transcription of the tumor suppressor ARF isoform from the CDKN2A gene (PubMed:15662416). Efficiently abrogates E2F1-dependent CDKN2A transactivation (PubMed:15662416). Regulates chondrogenesis through the transcriptional repression of specific genes via a mechanism that also requires histone deacetylation (PubMed:15337766). Regulates cell proliferation through the transcriptional regulation of genes involved in glycolysis (By similarity). Involved in adipogenesis through the regulation of genes involved in adipocyte differentiation (By similarity). Plays a key role in the differentiation of lymphoid progenitors into B and T lineages (PubMed:17495164). Promotes differentiation towards the B lineage by inhibiting the T-cell instructive Notch signaling pathway through the specific transcriptional repression of Notch downstream target genes (PubMed:17495164). Also regulates osteoclast differentiation (By similarity). May also play a role, independently of its transcriptional activity, in double-strand break repair via classical non-homologous end joining/cNHEJ (PubMed:26446488). Recruited to double-strand break sites on damage DNA, interacts with the DNA-dependent protein kinase complex and directly regulates its stability and activity in DNA repair (PubMed:26446488). May also modulate the splicing activity of KHDRBS1 toward BCL2L1 in a mechanism which is histone deacetylase-dependent and thereby negatively regulates the pro-apoptotic effect of KHDRBS1 (By similarity).
subunit: Homodimer (By similarity). Interacts with BCL6 (PubMed:9927193). Interacts with RELA; involved in the control by RELA of the accessibility of target gene promoters (PubMed:29813070). Interacts with AR (via NR LBD domain); the interaction is direct and androgen-dependent (By similarity). Interacts with NCOR1 (By similarity). Interacts with NCOR2 (By similarity). Interacts with SMAD4; the interaction is direct and stimulated by TGFB1 (By similarity). Interacts with HDAC1 (By similarity). Interacts with SP1; ZBTB7A prevents the binding to GC-rich motifs in promoters and represses the transcriptional activity of SP1 (By similarity). Interacts with the DNA-dependent protein kinase complex/DNA-PKc (PubMed:26446488). Interacts with KHDRBS1; negatively regulates KHDRBS1 splicing activity (By similarity).
disruption phenotype: Death around 16.5 dpc because of severe anemia with a profound block in early B-cell development (PubMed:17495164). Conditional knockout in erythroid cells, leads to the expression of fetal globin in peripheral blood of adult mice and inefficient erythroid terminal differentiation (PubMed:26816381).
ZBT7A_RAT / Q9QZ48 Zinc finger and BTB domain-containing protein 7A; Leukemia/lymphoma-related factor; Osteoclast-derived zinc finger protein from Rattus norvegicus (Rat) (see paper)
47% identity, 14% coverage
- function: Transcription factor that represses the transcription of a wide range of genes involved in cell proliferation and differentiation (By similarity) (PubMed:10477728). Directly and specifically binds to the consensus sequence 5'-[GA][CA]GACCCCCCCCC-3' and represses transcription both by regulating the organization of chromatin and through the direct recruitment of transcription factors to gene regulatory regions (By similarity) (PubMed:10477728). Negatively regulates SMAD4 transcriptional activity in the TGF-beta signaling pathway through these two mechanisms. That is, recruits the chromatin regulator HDAC1 to the SMAD4-DNA complex and in parallel prevents the recruitment of the transcriptional activators CREBBP and EP300 (By similarity). Collaborates with transcription factors like RELA to modify the accessibility of gene transcription regulatory regions to secondary transcription factors (By similarity). Also directly interacts with transcription factors like SP1 to prevent their binding to DNA. Functions as an androgen receptor/AR transcriptional corepressor by recruiting NCOR1 and NCOR2 to the androgen response elements/ARE on target genes. Thereby, negatively regulates androgen receptor signaling and androgen-induced cell proliferation. Involved in the switch between fetal and adult globin expression during erythroid cells maturation. Through its interaction with the NuRD complex regulates chromatin at the fetal globin genes to repress their transcription (By similarity). Specifically represses the transcription of the tumor suppressor ARF isoform from the CDKN2A gene. Efficiently abrogates E2F1-dependent CDKN2A transactivation. Regulates chondrogenesis through the transcriptional repression of specific genes via a mechanism that also requires histone deacetylation (By similarity). Regulates cell proliferation through the transcriptional regulation of genes involved in glycolysis. Involved in adipogenesis through the regulation of genes involved in adipocyte differentiation (By similarity). Plays a key role in the differentiation of lymphoid progenitors into B and T lineages. Promotes differentiation towards the B lineage by inhibiting the T-cell instructive Notch signaling pathway through the specific transcriptional repression of Notch downstream target genes (By similarity). Also regulates osteoclast differentiation (PubMed:10477728). May also play a role, independently of its transcriptional activity, in double-strand break repair via classical non-homologous end joining/cNHEJ. Recruited to double-strand break sites on damage DNA, interacts with the DNA-dependent protein kinase complex and directly regulates its stability and activity in DNA repair (By similarity). May also modulate the splicing activity of KHDRBS1 toward BCL2L1 in a mechanism which is histone deacetylase-dependent and thereby negatively regulates the pro-apoptotic effect of KHDRBS1 (By similarity).
subunit: Homodimer (By similarity). Interacts with BCL6 (By similarity). Interacts with RELA; involved in the control by RELA of the accessibility of target gene promoters (By similarity). Interacts with AR (via NR LBD domain); the interaction is direct and androgen- dependent (By similarity). Interacts with NCOR1 (By similarity). Interacts with NCOR2 (By similarity). Interacts with SMAD4; the interaction is direct and stimulated by TGFB1 (By similarity). Interacts with HDAC1 (By similarity). Interacts with SP1; ZBTB7A prevents the binding to GC-rich motifs in promoters and represses the transcriptional activity of SP1 (By similarity). Interacts with the DNA-dependent protein kinase complex/DNA-PKc (By similarity). Interacts with KHDRBS1; negatively regulates KHDRBS1 splicing activity (By similarity). - Alterations in the rat serum proteome induced by prepubertal exposure to bisphenol a and genistein.
Betancourt, Journal of proteome research 2014 - “...-acetylmuramoyl-tripeptide- d -alanyl- d -alanineligase 0.94 2 +1.70 1.11 D3ZYV1 WDrepeat-containingprotein60 0.81 4 1.76 0.82 Q9QZ48 zincfingerandBTBdomain-containingprotein7A 1.00 3 +3.14 0.89 a Proteins in bold are carcinogenesis-related proteins. b Positive- and a negative-fold change in protein expression indicate up- and down-regulation of protein expression relative to...”
XP_006240900 zinc finger and BTB domain-containing protein 7A isoform X2 from Rattus norvegicus
47% identity, 14% coverage
XP_011241884 PR domain zinc finger protein 4 isoform X1 from Mus musculus
Q80V63 PR domain zinc finger protein 4 from Mus musculus
40% identity, 10% coverage
NP_034765 Krueppel-like factor 1 from Mus musculus
46% identity, 21% coverage
P0DKX0 Zinc finger protein 728 from Homo sapiens
44% identity, 12% coverage
NP_995997 uncharacterized protein, isoform A from Drosophila melanogaster
40% identity, 12% coverage
- XenDB: full length cDNA prediction and cross species mapping in Xenopus laevis
Sczyrba, BMC genomics 2005 - “...AAG46059 SKELETOR 68 NP_611728 CG13532-PA 57 AAN61340 BcDNA:GH10711 69 NP_651343 CG13651-PA 58 NP_729183 CG10121-PA 70 NP_995997 CG12605-PA 59 AAO39528 RE22242p 71 NP_610067 CG9335-PA Discussion Comparative approaches to important biological problems have resulted in enormous progress in the past decades. The advent of genomic and proteomic approaches...”
NP_001308451 zinc finger protein 845 from Homo sapiens
45% identity, 8% coverage
Q6NSZ9 Zinc finger and SCAN domain-containing protein 25 from Homo sapiens
44% identity, 14% coverage
ZNF93_HUMAN / P35789 Zinc finger protein 93; Zinc finger protein 505; Zinc finger protein HTF34 from Homo sapiens (Human) (see paper)
NP_112495 zinc finger protein 93 from Homo sapiens
40% identity, 12% coverage
- function: Transcription factor specifically required to repress long interspersed nuclear element 1 (L1) retrotransposons: recognizes and binds L1 sequences and repress their expression by recruiting a repressive complex containing TRIM28/KAP1 (PubMed:25274305). Not able to repress expression of all subtypes of L1 elements. Binds to the 5' end of L1PA4, L1PA5 and L1PA6 subtypes, and some L1PA3 subtypes. Does not bind to L1PA7 or older subtypes nor at the most recently evolved L1PA2 and L1Hs. 50% of L1PA3 elements have lost the ZNF93-binding site, explaining why ZNF93 is not able to repress their expression (PubMed:25274305).
- ZNF93 increases resistance to ET-743 (Trabectedin; Yondelis) and PM00104 (Zalypsis) in human cancer cell lines.
Duan, PloS one 2009 - GeneRIF: zinc finger proteins, and ZNF93 in particular, are involved in resistance to ET-743 and PM00104
- Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
Rose, Molecular medicine (Cambridge, Mass.) - GeneRIF: Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
- Structure and functional mapping of the KRAB-KAP1 repressor complex.
Stoll, The EMBO journal 2022 - “...was deleted, generating the T4LRBCCB1 plasmid. A codonoptimized gene encoding residues 271 of ZNF93 (UniProt P35789) was cloned into MCS1 of pCDFDuet, preceded by TwinStrepII and MBP purification tags and a HRV 3C protease cleavage site. For expression in mammalian cells, fulllength KAP1 (UniProt Q13263) with...”
- “...structure prediction for ZNF93 was obtained from the EMBLEBI AlphaFold Protein Structure Database, accession number P35789 (Jumper etal , 2021 ; Varadi etal , 2022 ). The structure of the ZNF93 KRABKAP1 RBCC complex was predicted by submitting the sequences from ZNF93 (amino acids 271) and...”
- Structure of KAP1 tripartite motif identifies molecular interfaces required for retroelement silencing.
Stoll, Proceedings of the National Academy of Sciences of the United States of America 2019 - “...residue. A synthetic gene encoding the KRAB domain (residues 171) from ZNF93 (UniProt ID code P35789) codon-optimized for E. coli was expressed from the pET20 plasmid (Novagen) with N-terminal Twin-StrepII and maltose binding protein (MBP) affinity tags (the MBP tag was also required for protein solubility)....”
SS1G_01109 hypothetical protein from Sclerotinia sclerotiorum 1980 UF-70
45% identity, 16% coverage
- Changes in the Sclerotinia sclerotiorum transcriptome during infection of Brassica napus
Seifbarghi, BMC genomics 2017 - “...2.3 SS1G_06361 fungal specific transcription factor domain - - - - - 2.1 2. Cys2His2 SS1G_01109 C2H2 transcription factor 19.8 26.1 26.6 15.6 - - SS1G_01684 C2H2 transcription factor 2.6 3.1 2.7 2.0 - - SS1G_04676 C2H2 transcription factor 2.0 - - - - 7.3 SS1G_07355...”
- “...Pcz1 were differentially expressed at various stages of infection in the current study, including SS1G_10532, SS1G_01109 and SS1G_02054 (Table 6 ). Several genes encoding other types of TFs involved in fungal development were also up-regulated and are discussed below. 6.2 Phosphorylation-dependent signaling The S. sclerotiorum genome...”
NP_476732 snail from Drosophila melanogaster
P08044 Protein snail from Drosophila melanogaster
39% identity, 19% coverage
- Snail synchronizes endocycling in a TOR-dependent manner to coordinate entry and escape from endoreplication pausing during the Drosophila critical weight checkpoint.
Zeng, PLoS biology 2020 - GeneRIF: Before and during the critical weight (CW) checkpoint, Drosophila transcription factor Snail is highly expressed in the larval prothoracic gland (PG). Snail peaks coincide with two peaks of PG cells entering S phase and a slowing of DNA synthesis between the peaks. The synchronization of PG cells into S phase via Snail represents the mechanistic link used to terminate the CW checkpoint.
- Collective cell migration and metastases induced by an epithelial-to-mesenchymal transition in Drosophila intestinal tumors.
Campbell, Nature communications 2019 - GeneRIF: Study finds that expression of Snail (Sna) in adult Drosophila intestinal Apc-Ras tumors leads to the formation of macrometastases, which shows remarkable parallels to human metastases and reveals that Snail activates a partial epithelial-to-mesenchymal transition in tumor cells and that tumor cells undergo collective cell migration and seed polyclonal metastases.
- Cardiac Snail family of transcription factors directs systemic lipid metabolism in Drosophila.
Liu, PLoS genetics 2019 - GeneRIF: our results reveal a novel and specific role of Sna TFs in the heart on systemic lipid homeostasis maintenance that is independent of cardiac development and function and involves the governance of triglyceride synthesis and breakdown, energy utilization, and lipid droplet dynamics in the fat body.
- Snail modulates JNK-mediated cell death in Drosophila.
Wu, Cell death & disease 2019 - GeneRIF: Snail modulates JNK-mediated cell death in Drosophila.
- Differential roles of the Drosophila EMT-inducing transcription factors Snail and Serpent in driving primary tumour growth.
Campbell, PLoS genetics 2018 - GeneRIF: While either Snail or Serpent induced a profound loss of epithelial polarity and tissue organisation, Serpent but not Snail also induced an increase in the size of wing discs. Furthermore, the Serpent-induced tumour-like tissues were able to grow extensively when transplanted into the abdomen of adult hosts.
- Polarity protein Par3/Bazooka follows myosin-dependent junction repositioning.
Weng, Developmental biology 2017 - GeneRIF: during gastrulation of Drosophila embryos, Sna expression downregulates polarity protein Baz which in turn results in junction disassembly at protein levels.
- Myosin-dependent remodeling of adherens junctions protects junctions from Snail-dependent disassembly.
Weng, The Journal of cell biology 2016 - GeneRIF: evidence for mechanosensitivity of cell-cell junctions and implications that myosin-mediated tension can prevent Snail-driven Eepithelial-mesenchymal transitions
- Snail controls proliferation of Drosophila ovarian epithelial follicle stem cells, independently of E-cadherin.
Tseng, Developmental biology 2016 (PubMed)- GeneRIF: Disruption of Snail expression in follicle stem cells compromises proliferation, but not maintenance. FSCs with excessive Snail expression had increased proliferation and lifespan, accompanied by a moderate decrease inE-cadherin expression (required for adhesion of FSCs to their niche) at the junction between their adjacent cells, indicating a conserved role of Snail in E-cadherin inhibition.
- More
- High-resolution line-scan Brillouin microscopy for live imaging of mechanical properties during embryo development
Bevilacqua, Nature methods 2023 - “...S-transferase (GST)-tagged portion of the Drosophila Snail protein (encompassing amino acids 1200 of Uniprot ID P08044 ) was expressed in Escherichia coli and purified from lysates of bacteria expressing the SnailGST fusion protein using beads with immobilized glutathione. The fusion protein was eluted from beads using...”
- Identification of protein related to dietary vitamin B<sub>3</sub> deficiency in Mediterranean fruit fly larvae
Cho, Analytical science advances 2021 - “...Chitinaselike protein Idgf4 4 36 (32) Q9W303 Chitin catabolic process Protein snail 2 39 (32) P08044 Dorsal/ventral axis specification Protein winged eye 5 58 (32) Q3LHL9 Imaginal disc morphogenesis Protein tumorous imaginal discs ( DNAJA3 ) 3 46 (32) Q27237 Tumor suppressor in larval imaginal disks...”
- A survey of well conserved families of C2H2 zinc-finger genes in Daphnia
Seetharam, BMC genomics 2010 - “...OVOL1 (O14753) OVOrb (P51521) LIN48 (Q19996) OVO (Dappu-290491) 191:57-1323 OVOL2 (Q9BRP0) SNAIL SNAIL3 (NP_840101) SNAIL (P08044) K02D7 (NP_499902) Dappu- 53927 39:954341-955431 SNAIL2 (O43623) ESG (P25932) SCRT1(NP_491001) Dappu- 129982 110:193847-194734 SNAIL1 (O95863) WOR (NP_476601) CES1 (NP_492338) ESG (Dappu-347447) 23:1247838-1249532 hSCRT1 (Q9BWW7) SCRT (Q24140) Dappu- 61957 110:238640-239641 hSCRT2...”
ZN768_HUMAN / Q9H5H4 Zinc finger protein 768 from Homo sapiens (Human) (see 2 papers)
NP_078947 zinc finger protein 768 from Homo sapiens
45% identity, 14% coverage
- function: Binds to mammalian-wide interspersed repeat (MIRs) sequences in euchromatin and promoter regions of genes at the consensus sequence 5'-GCTGTGTG-[N20]-CCTCTCTG-3', consisting of two anchor regions connected by a linker region; the linker region probably does not contribute to the binding specificity (PubMed:30476274). Required for cell homeostasis (PubMed:34404770). May be involved in transcriptional regulation (Probable).
subunit: Interacts (via zinc-finger domains) with TP53 (via N- terminus); interaction might be facilitated by TP53 oligomerization state (PubMed:34404770). Interacts with ELP3 (PubMed:30476274). - Quantitative proteomics analysis in small cell carcinoma of cervix reveals novel therapeutic targets.
Qiu, Clinical proteomics 2023 - “...ASF1B Histone chaperone ASF1B ASF1B_HUMAN 4.550893393 23.43988185 0.004111323 0.046576686 4228.997559 99,127.20313 4228.997559 117,532.7544 0 82,982.34381 Q9H5H4 ZNF768 Zinc finger protein 768 ZN768_HUMAN 4.421533747 21.42961086 0.007044493 0.060974403 1769.069214 37,910.46485 1769.069214 33,820.35429 2.27E-13 25,296.06673 Q9NX00 TMEM160 Transmembrane protein 160 TM160_HUMAN 4.409021661 21.2445615 0.04356989 0.16138934 88,124.80078 1,872,172.75 649,803.9105 1,881,539.407...”
- MIR sequences recruit zinc finger protein ZNF768 to expressed genes.
Rohrmoser, Nucleic acids research 2019 - “...to the manufacturer's protocol. Purification of ZNF768 Expression plasmids of human ZNF768 (UniProt accession number Q9H5H4) were cloned from a synthetic gene that was codon optimized for expression in Escherichia coli cells (Gene Art, Regensburg). A full length ZNF768 (1540) construct and a construct consisting of...”
- Identification of CTCF as a master regulator of the clustered protocadherin genes.
Golan-Mashiach, Nucleic acids research 2012 - “...chaperoning, histone assembly, cell proliferation, and regulation of tumor suppressors TP53/p53 and ARF 2 10 Q9H5H4 Zinc finger protein 768 ZN768 May be involved in transcriptional regulation 2 11 O60828 Polyglutamine-binding protein PQBP1 Involved with transcription activation 2 12 Q6DD87 Zinc finger protein 787 ZN787 May...”
- Splicing factor 2-associated protein p32 participates in ribosome biogenesis by regulating the binding of Nop52 and fibrillarin to preribosome particles
Yoshikawa, Molecular & cellular proteomics : MCP 2011 - “...108 109 110 111 112 113 Unknown Q96JP5 Q9H5H4 Q14966 Q8NAF0 Q5VZL5 Q8N9Z2 Q9Y4P3 Q9UJZ1 Q9P2N5 Q5T8P6 Q9NWS8 ZFP91_HUMAN ZN768_HUMAN ZN638_HUMAN ZN579_HUMAN...”
- MIR sequences recruit zinc finger protein ZNF768 to expressed genes.
Rohrmoser, Nucleic acids research 2019 - GeneRIF: A report on the specific binding of zinc finger protein ZNF768 to the sequence motif GCTGTGTG (N20) CCTCTCTG in the core region of mammalian-wide interspersed repeats.
- Diagnostic potential of zinc finger protein-specific autoantibodies and associated linear B-cell epitopes in colorectal cancer.
O'Reilly, PloS one 2015 - GeneRIF: High ZNF768 expression is associated with colorectal cancer.
Q9HBT8 Zinc finger protein 286A from Homo sapiens
42% identity, 15% coverage
- Serum Proteomic Analysis of Cannabis Use Disorder in Male Patients
Alasmari, Molecules (Basel, Switzerland) 2021 - “...0.04 1.6 UP 56 1669 P02753 Retinol-binding protein 4 RET4_HUMAN 0.02 1.6 UP 35 1473 Q9HBT8 Zinc finger protein 286A Z286A_HUMAN 0.04 1.6 UP 55 1138 Q6ZN19 Zinc finger protein 841 ZN841_HUMAN 0.02 1.6 UP 105 788 A8TX70 Collagen alpha-5(VI) chain CO6A5_HUMAN 0.04 1.5 UP 97...”
Zfp768 zinc finger protein 768 from Mus musculus
45% identity, 13% coverage
Gm14325 novel KRAB box and zinc finger, C2H2 type domain containing protein from Mus musculus
43% identity, 15% coverage
- Genome-wide Methylation Dynamics and Context-dependent Gene Expression Variability in Differentiating Preadipocytes
Yadav, Journal of the Endocrine Society 2024 - “...the promoters of the genes MBD1, MBD3, DNMT3A, LYZ2, CD36 , TET1 , GM10354, and GM14325 ( Fig. 5 ). In previous studies and based on qRT-PCR expression analysis here, entrenched upregulation of DNA methylation often leads to gene repression. However, in the case of Lyz2,...”
- “...(A) MBD1, (B) MBD3, (C) DNMT3A, (D) Lyz2, (E) CD36, (F) Tet1, (G) GM10354, (H) GM14325, and average DNA methylation level at the promoters of these genes along with genes expression profiles at indicated time points. Identification and Validation of Differentially Expressed Genes The comparative cycle...”
- Structural and molecular characterization of paraventricular thalamic glucokinase-expressing neuronal circuits in the mouse
Gaspari, The Journal of comparative neurology 2022 - “...6.335414 Kinesin family member 3B (Kif3b) Rnf31 0.51 .040984338 4.278394 Ring finger protein 31 (Rnf31) Gm14325 0.51 .02836186 2.765817 Predicted gene 14325 (Gm14325) Hs3st5 0.51 .037133655 2.99095 Heparan sulfate (glucosamine) 3Osulfotransferase 5 (Hs3st5) 1700017B05Rik 0.51 .003441896 4.646979 RIKEN cDNA 1700017B05 gene (1700017B05Rik) Rhof 0.51 .015257988 4.340154...”
- Cryptic sequence features in the active postmortem transcriptome
Noble, BMC genomics 2018 - “...average. ( a ) Mouse: Open circle, represents Gm11007, Gm2007, Gm4631, Gm14434, Gm2026, Gm14305, Gm14399, Gm14325, Zfp969, Gm4724, Gm14326 transcripts; closed circle, Zfp967, Zfp969, Zfp968; open square, Gm14410; closed square, Gm14305; open triangle, Gm14322; closed triangle, Gm14308; closed diamond, Gm14412. All points are the average of...”
ZN658_HUMAN / Q5TYW1 Zinc finger protein 658 from Homo sapiens (Human) (see paper)
NP_001304845 zinc finger protein 658 from Homo sapiens
43% identity, 7% coverage
For advice on how to use these tools together, see
Interactive tools for functional annotation of bacterial genomes.
The PaperBLAST database links 793,807 different protein sequences to 1,259,118 scientific articles. Searches against EuropePMC were last performed on March 13 2025.
PaperBLAST builds a database of protein sequences that are linked
to scientific articles. These links come from automated text searches
against the articles in EuropePMC
and from manually-curated information from GeneRIF, UniProtKB/Swiss-Prot,
BRENDA,
CAZy (as made available by dbCAN),
BioLiP,
CharProtDB,
MetaCyc,
EcoCyc,
TCDB,
REBASE,
the Fitness Browser,
and a subset of the European Nucleotide Archive with the /experiment tag.
Given this database and a protein sequence query,
PaperBLAST uses protein-protein BLAST
to find similar sequences with E < 0.001.
To build the database, we query EuropePMC with locus tags, with RefSeq protein
identifiers, and with UniProt
accessions. We obtain the locus tags from RefSeq or from MicrobesOnline. We use
queries of the form "locus_tag AND genus_name" to try to ensure that
the paper is actually discussing that gene. Because EuropePMC indexes
most recent biomedical papers, even if they are not open access, some
of the links may be to papers that you cannot read or that our
computers cannot read. We query each of these identifiers that
appears in the open access part of EuropePMC, as well as every locus
tag that appears in the 500 most-referenced genomes, so that a gene
may appear in the PaperBLAST results even though none of the papers
that mention it are open access. We also incorporate text-mined links
from EuropePMC that link open access articles to UniProt or RefSeq
identifiers. (This yields some additional links because EuropePMC
uses different heuristics for their text mining than we do.)
For every article that mentions a locus tag, a RefSeq protein
identifier, or a UniProt accession, we try to select one or two
snippets of text that refer to the protein. If we cannot get access to
the full text, we try to select a snippet from the abstract, but
unfortunately, unique identifiers such as locus tags are rarely
provided in abstracts.
PaperBLAST also incorporates manually-curated protein functions:
- Proteins from NCBI's RefSeq are included if a
GeneRIF
entry links the gene to an article in
PubMed®.
GeneRIF also provides a short summary of the article's claim about the
protein, which is shown instead of a snippet.
- Proteins from Swiss-Prot (the curated part of UniProt)
are included if the curators
identified experimental evidence for the protein's function (evidence
code ECO:0000269). For these proteins, the fields of the Swiss-Prot entry that
describe the protein's function are shown (with bold headings).
- Proteins from BRENDA,
a curated database of enzymes, are included if they are linked to a paper in PubMed
and their full sequence is known.
- Every protein from the non-redundant subset of
BioLiP,
a database
of ligand-binding sites and catalytic residues in protein structures, is included. Since BioLiP itself
does not include descriptions of the proteins, those are taken from the
Protein Data Bank.
Descriptions from PDB rely on the original submitter of the
structure and cannot be updated by others, so they may be less reliable.
(For SitesBLAST and Sites on a Tree, we use a larger subset of BioLiP so that every
ligand is represented among a group of structures with similar sequences, but for
PaperBLAST, we use the non-redundant set provided by BioLiP.)
- Every protein from EcoCyc, a curated
database of the proteins in Escherichia coli K-12, is included, regardless
of whether they are characterized or not.
- Proteins from the MetaCyc metabolic pathway database
are included if they are linked to a paper in PubMed and their full sequence is known.
- Proteins from the Transport Classification Database (TCDB)
are included if they have known substrate(s), have reference(s),
and are not described as uncharacterized or putative.
(Some of the references are not visible on the PaperBLAST web site.)
- Every protein from CharProtDB,
a database of experimentally characterized protein annotations, is included.
- Proteins from the CAZy database of carbohydrate-active enzymes
are included if they are associated with an Enzyme Classification number.
Even though CAZy does not provide links from individual protein sequences to papers,
these should all be experimentally-characterized proteins.
- Proteins from the REBASE database
of restriction enzymes are included if they have known specificity.
- Every protein with an evidence-based reannotation (based on mutant phenotypes)
in the Fitness Browser is included.
- Sequence-specific transcription factors (including sigma factors and DNA-binding response regulators)
with experimentally-determined DNA binding sites from the
PRODORIC database of gene regulation in prokaryotes.
- Putative transcription factors from RegPrecise
that have manually-curated predictions for their binding sites. These predictions are based on
conserved putative regulatory sites across genomes that contain similar transcription factors,
so PaperBLAST clusters the TFs at 70% identity and retains just one member of each cluster.
- Coding sequence (CDS) features from the
European Nucleotide Archive (ENA)
are included if the /experiment tag is set (implying that there is experimental evidence for the annotation),
the nucleotide entry links to paper(s) in PubMed,
and the nucleotide entry is from the STD data class
(implying that these are targeted annotated sequences, not from shotgun sequencing).
Also, to filter out genes whose transcription or translation was detected, but whose function
was not studied, nucleotide entries or papers with more than 25 such proteins are excluded.
Descriptions from ENA rely on the original submitter of the
sequence and cannot be updated by others, so they may be less reliable.
Except for GeneRIF and ENA,
the curated entries include a short curated
description of the protein's function.
For entries from BioLiP, the protein's function may not be known beyond binding to the ligand.
Many of these entries also link to articles in PubMed.
For more information see the
PaperBLAST paper (mSystems 2017)
or the code.
You can download PaperBLAST's database here.
Changes to PaperBLAST since the paper was written:
- November 2023: incorporated PRODORIC and RegPrecise. Many PRODORIC entries were not linked to a protein sequence (no UniProt identifier), so we added this information.
- February 2023: BioLiP changed their download format. PaperBLAST now includes their non-redundant subset. SitesBLAST and Sites on a Tree use a larger non-redundant subset that ensures that every ligand is represented within each cluster. This should ensure that every binding site is represented.
- June 2022: incorporated some coding sequences from ENA with the /experiment tag.
- March 2022: incorporated BioLiP.
- April 2020: incorporated TCDB.
- April 2019: EuropePMC now returns table entries in their search results. This has expanded PaperBLAST's database, but most of the new entries are of low relevance, and the resulting snippets are often just lists of locus tags with annotations.
- February 2018: the alignment page reports the conservation of the hit's functional sites (if available from from Swiss-Prot or UniProt)
- January 2018: incorporated BRENDA.
- December 2017: incorporated MetaCyc, CharProtDB, CAZy, REBASE, and the reannotations from the Fitness Browser.
- September 2017: EuropePMC no longer returns some table entries in their search results. This has shrunk PaperBLAST's database, but has also reduced the number of low-relevance hits.
Many of these changes are described in Interactive tools for functional annotation of bacterial genomes.
PaperBLAST cannot provide snippets for many of the papers that are
published in non-open-access journals. This limitation applies even if
the paper is marked as "free" on the publisher's web site and is
available in PubmedCentral or EuropePMC. If a journal that you publish
in is marked as "secret," please consider publishing elsewhere.
Many important articles are missing from PaperBLAST, either because
the article's full text is not in EuropePMC (as for many older
articles), or because the paper does not mention a protein identifier such as a locus tag, or because of PaperBLAST's heuristics. If you notice an
article that characterizes a protein's function but is missing from
PaperBLAST, please notify the curators at UniProt
or add an entry to GeneRIF.
Entries in either of these databases will eventually be incorporated
into PaperBLAST. Note that to add an entry to UniProt, you will need
to find the UniProt identifier for the protein. If the protein is not
already in UniProt, you can ask them to create an entry. To add an
entry to GeneRIF, you will need an NCBI Gene identifier, but
unfortunately many prokaryotic proteins in RefSeq do not have
corresponding Gene identifers.
References
PaperBLAST: Text-mining papers for information about homologs.
M. N. Price and A. P. Arkin (2017). mSystems, 10.1128/mSystems.00039-17.
Europe PMC in 2017.
M. Levchenko et al (2017). Nucleic Acids Research, 10.1093/nar/gkx1005.
Gene indexing: characterization and analysis of NLM's GeneRIFs.
J. A. Mitchell et al (2003). AMIA Annu Symp Proc 2003:460-464.
UniProt: the universal protein knowledgebase.
The UniProt Consortium (2016). Nucleic Acids Research, 10.1093/nar/gkw1099.
BRENDA in 2017: new perspectives and new tools in BRENDA.
S. Placzek et al (2017). Nucleic Acids Research, 10.1093/nar/gkw952.
The EcoCyc database: reflecting new knowledge about Escherichia coli K-12.
I. M. Keeseler et al (2016). Nucleic Acids Research, 10.1093/nar/gkw1003.
The MetaCyc database of metabolic pathways and enzymes.
R. Caspi et al (2018). Nucleic Acids Research, 10.1093/nar/gkx935.
CharProtDB: a database of experimentally characterized protein annotations.
R. Madupu et al (2012). Nucleic Acids Research, 10.1093/nar/gkr1133.
The carbohydrate-active enzymes database (CAZy) in 2013.
V. Lombard et al (2014). Nucleic Acids Research, 10.1093/nar/gkt1178.
The Transporter Classification Database (TCDB): recent advances
M. H. Saier, Jr. et al (2016). Nucleic Acids Research, 10.1093/nar/gkv1103.
REBASE - a database for DNA restriction and modification: enzymes, genes and genomes.
R. J. Roberts et al (2015). Nucleic Acids Research, 10.1093/nar/gku1046.
Deep annotation of protein function across diverse bacteria from mutant phenotypes.
M. N. Price et al (2016). bioRxiv, 10.1101/072470.
by Morgan Price,
Arkin group
Lawrence Berkeley National Laboratory