PaperBLAST
PaperBLAST Hits for 58 a.a. (ERKRMRNRIA...)
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>58 a.a. (ERKRMRNRIA...)
ERKRMRNRIAASKSRKRKLERIARLEEKVKTLKAQNSELASTANMLREQVAQLKQKVM
Running BLASTp...
Found 50 similar proteins in the literature:
NP_001185876 transcription factor Jun from Oryctolagus cuniculus
98% identity, 17% coverage
- [Expression of intercellular cell adhesion molecule-1, interleukin-10 and the activation of activator protein-1 in ventilator-induced lung injury in rabbits].
Zhang, Zhonghua jie he he hu xi za zhi = Zhonghua jiehe he huxi zazhi = Chinese journal of tuberculosis and respiratory diseases 2010 (PubMed)- GeneRIF: ICAM1 and IL10 were upregulated in ventilator-induced lung injury. Nuclear transcription factor AP-1 may be responsible for this upregulation.
NP_001252779 transcription factor AP-1 from Macaca mulatta
98% identity, 17% coverage
- Arthropod transcriptional activator protein-1 (AP-1) aids tick-rickettsial pathogen survival in the cold
Khanal, Scientific reports 2018 - “...acc. no. NP_068607) AP-1 and 44% with Macaca mulatta (Rhesus monkey) AP-1 (GenBank acc. no. NP_001252779) and 46% with Homo sapiens (human) AP-1 (GenBank acc. no. NP_002219) orthologs (Fig. 2B ). ClustalW alignment also showed absence of some of the sequences at the N-terminal end of...”
- “...microplus c-Jun AP-1), NP_068607 ( R . norvegicus AP-1), NP_034721 ( M . musculus AP-1), NP_001252779 ( M . mulatta AP-1) and NP_002219 ( H . sapiens AP-1). Statistics Statistical analysis was performed using GraphPad Prism6 software and Microsoft Excel 2016. The average means from the...”
XP_005620302 transcription factor AP-1 from Canis lupus familiaris
98% identity, 17% coverage
JUN_MOUSE / P05627 Transcription factor Jun; AH119; Activator protein 1; AP1; Proto-oncogene c-Jun; Transcription factor AP-1 subunit Jun; V-jun avian sarcoma virus 17 oncogene homolog; Jun A from Mus musculus (Mouse) (see 9 papers)
NP_034721 transcription factor Jun from Mus musculus
98% identity, 17% coverage
- function: Transcription factor that recognizes and binds to the AP-1 consensus motif 5'-TGA[GC]TCA-3' (PubMed:14707112). Heterodimerizes with proteins of the FOS family to form an AP-1 transcription factor complex, thereby enhancing its DNA binding activity to the AP-1 consensus sequence 5'-TGA[GC]TCA-3' and enhancing its transcriptional activity (PubMed:2498083). Together with FOSB, plays a role in activation-induced cell death of T cells by binding to the AP-1 promoter site of FASLG/CD95L, and inducing its transcription in response to activation of the TCR/CD3 signaling pathway (By similarity). Promotes activity of NR5A1 when phosphorylated by HIPK3 leading to increased steroidogenic gene expression upon cAMP signaling pathway stimulation (PubMed:17210646). Involved in activated KRAS- mediated transcriptional activation of USP28 (By similarity). Binds to the USP28 promoter (By similarity).
subunit: Heterodimer with either BATF3 or ATF7 (By similarity). Heterodimer with FOS (PubMed:29272704). Heterodimer with FOSB isoform 1 and 2 (PubMed:29272704). Component of an AP-1 transcription factor complex composed of JUN-FOS heterodimers (PubMed:2498083). As part of the AP-1 transcription factor complex, forms heterodimers with FOSB, thereby binding to the AP-1 consensus sequence and stimulating transcription (PubMed:2498083). The ATF7/JUN heterodimer is essential for ATF7 transactivation activity. Interacts with SP1, SPIB and TCF20. Interacts with COPS5; the interaction leads indirectly to its phosphorylation. Component of the SMAD3/SMAD4/JUN/FOS/complex which forms at the AP1 promoter site. The SMAD3/SMAD4 heterodimer acts synergistically with the JUN/FOS heterodimer to activate transcription in response to TGF-beta (By similarity). Interacts (via its basic DNA binding and leucine zipper domains) with SMAD3 (via an N-terminal domain); the interaction is required for TGF-beta-mediated transactivation of the SMAD3/SMAD4/JUN/FOS/complex (By similarity). Interacts with TSC22D3 (via N-terminus); the interaction inhibits the binding of active AP1 to its target DNA (PubMed:11397794). Interacts with HIVEP3 and MYBBP1A (PubMed:14707112, PubMed:9447996). Interacts with methylated RNF187 (PubMed:20852630). Binds to HIPK3. Interacts (when phosphorylated) with FBXW7 (By similarity). Interacts with PRR7 (PubMed:27458189). Found in a complex with PRR7 and FBXW7 (By similarity). Interacts with PRR7 and FBXW7; the interaction inhibits ubiquitination-mediated JUN degradation promoting its phosphorylation and transcriptional activity (By similarity). Interacts with RBM39 (PubMed:11704680). Interacts with PAGE4 (By similarity). Interacts with FOSL1 and FOSL2 (PubMed:29272704). Interacts with ARK2N and CSNK2B; the interaction with ARK2N is mediated by CSNK2B (By similarity). - Clonal memory of colitis accumulates and promotes tumor growth.
Buenrostro, Research square 2025 - “...AlphaFold3-based structure prediction The full amino acid sequences and features of murine Fos (P01101), Jun (P05627), Foxp1 (P58462), Foxa1 (P35582), Foxn2 (E9Q7L6), and Foxj2 (Q9ES18) were downloaded from UniProt. Structures were predicted using Alphafold3 through Alphafold Server by combining nucleotide sequences and amino acid sequences. Each...”
- Puerarin Induces Molecular Details of Ferroptosis-Associated Anti-Inflammatory on RAW264.7 Macrophages
Zeng, Metabolites 2022 - “...anti-inflammatory. Gene Symbol Uniprot ID Protein Name Degree Akt1 P31750 RAC-alpha serine/threonine-protein kinase 30 Jun P05627 Transcription factor Jun 26 Stat3 P42227 Signal transducer and activator of transcription 3 24 Esr1 P19785 Estrogen receptor 20 Hsp90aa1 P07901 Heat shock protein HSP 90-alpha 20 Tnf P06804 Tumor...”
- Safety switch optimization enhances antibody-mediated elimination of CAR T cells.
Shabaneh, Frontiers in molecular medicine 2022 - “...(NWSHPQFEK) and (G4S)2 linked the scFv to hinge. To generate tricistronic constructs, murine c-Jun (Uniprot P05627 aa1-334) was cloned upstream of m19.CAR, linked by a T2A sequence. Retrovirus production Lentivirus was produced by transient transduction of transfer plasmid and 3rd generation helper plasmids using polyethylenimine (Polyplus)...”
- Functional prediction of de novo uni-genes from chicken transcriptomic data following infectious bursal disease virus at 3-days post-infection.
Azli, BMC genomics 2021 - “...Up 1 0.965 ccgccgGCTTTaatt Barbie box n/a 1_CL41Contig6 Up 1 1 tgACGTCa c-Jun / AP-1 P05627 1_CL1576Contig1 Down 0.997 0.893 cctcctttctCTTCT HSF1 P10961 1_CL1679Contig3 Down 1 1 tGACGTta c-Jun / AP-1 P05627 1_CL2484Contig1 Down 1 1 cgtgACCCC CF-1 / USP P20153 1_CL2572Contig1 Down 0.953 0.983 gttCCGGAacgttct...”
- Integrated network pharmacology and targeted metabolomics to reveal the mechanism of nephrotoxicity of triptolide.
Huang, Toxicology research 2019 - The Progestin Receptor Interactome in the Female Mouse Hypothalamus: Interactions with Synaptic Proteins Are Isoform Specific and Ligand Dependent.
Acharya, eNeuro 2017 - “...hormone receptor-associated protein complex MED12 A2AGH6 + c-Fos p FOS P01101 + c-Jun p JUN P05627 + Kruppel-like factor 4 KLF4 Q60793 + Autophagy-related protein 3 ATG3 Q9CPX6 + Autophagy related protein 12 ATG12 Q9CQY1 + BCL2 antagonist/killer 1 BAK O08734 + + Forkhead box O1...”
- CR3 and Dectin-1 Collaborate in Macrophage Cytokine Response through Association on Lipid Rafts and Activation of Syk-JNK-AP-1 Pathway.
Huang, PLoS pathogens 2015 - “...CD18, P11835; Dectin-1, Q6QLQ4; Syk, P43404; JNK, Q91Y86 (JNK1) and Q9WTU6 (JNK2); c-Fos, P01101; c-Jun, P05627; Raf-1, Q99N57; PLC2, Q8CIH5; Akt, P31750; ERK, Q63844 (ERK1) and P63085 (ERK2); p38, P47811; IKK, Q60680; IKK, O88351; IB, Q9Z1E3; NF-Bp65, Q04207; PKC, P16054; PKC, P23298; PKC, Q02111; -actin, P60710;...”
- The MEKK1 SWIM domain is a novel substrate receptor for c-Jun ubiquitylation.
Rieger, The Biochemical journal 2012 - “...were selected for mutagenesis in c-Jun. UniProt accession numbers for the sequences are as follows: P05627 (c-Jun), P09450 (JunB), P15066 (JunD), P01101 (c-Fos), and P47930 (Fra2). ( C ) GST-SWIM pulldown assay using c-Jun and mutant c-Jun proteins from transfected 293T cells. The upper panel shows...”
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- Knockdown of BUB1B Inhibits the Proliferation, Migration, and Invasion of Colorectal Cancer by Regulating the JNK/c-Jun Signaling Pathway.
Zeng, Cancer biotherapy & radiopharmaceuticals 2024 (PubMed)- GeneRIF: Knockdown of BUB1B Inhibits the Proliferation, Migration, and Invasion of Colorectal Cancer by Regulating the JNK/c-Jun Signaling Pathway.
- Gasdermin E promotes translocation of p65 and c-jun into nucleus in keratinocytes for progression of psoriatic skin inflammation.
Long, Cell death & disease 2024 - GeneRIF: Gasdermin E promotes translocation of p65 and c-jun into nucleus in keratinocytes for progression of psoriatic skin inflammation.
- The Role of Activator Protein-1 Complex in Diabetes-Associated Atherosclerosis: Insights From Single-Cell RNA Sequencing.
Khan, Diabetes 2024 (PubMed)- GeneRIF: The Role of Activator Protein-1 Complex in Diabetes-Associated Atherosclerosis: Insights From Single-Cell RNA Sequencing.
- Hsp90aa1/JUN/Ccl2 regulatory axis mediates migration and differentiation of NSPCs, promoting the onset and progression of early post-ischemic stroke epilepsy.
Hu, Neurobiology of disease 2024 (PubMed)- GeneRIF: Hsp90aa1/JUN/Ccl2 regulatory axis mediates migration and differentiation of NSPCs, promoting the onset and progression of early post-ischemic stroke epilepsy.
- Jun-activated SOCS1 enhances ubiquitination and degradation of CCAAT/enhancer-binding protein β to ameliorate cerebral ischaemia/reperfusion injury.
He, The Journal of physiology 2024 (PubMed)- GeneRIF: Jun-activated SOCS1 enhances ubiquitination and degradation of CCAAT/enhancer-binding protein beta to ameliorate cerebral ischaemia/reperfusion injury.
- Hepatocytic AP-1 and STAT3 contribute to chemotaxis in alphanaphthylisothiocyanate-induced cholestatic liver injury.
Luo, Toxicology letters 2023 (PubMed)- GeneRIF: Hepatocytic AP-1 and STAT3 contribute to chemotaxis in alphanaphthylisothiocyanate-induced cholestatic liver injury.
- Dach1 deficiency drives alveolar epithelium apoptosis in pulmonary fibrosis via modulating C-Jun/Bim activity.
Lu, Translational research : the journal of laboratory and clinical medicine 2023 (PubMed)- GeneRIF: Dach1 deficiency drives alveolar epithelium apoptosis in pulmonary fibrosis via modulating C-Jun/Bim activity.
- JNK-JUN-NCOA4 axis contributes to chondrocyte ferroptosis and aggravates osteoarthritis via ferritinophagy.
Sun, Free radical biology & medicine 2023 (PubMed)- GeneRIF: JNK-JUN-NCOA4 axis contributes to chondrocyte ferroptosis and aggravates osteoarthritis via ferritinophagy.
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XP_011283269 transcription factor AP-1 from Felis catus
98% identity, 17% coverage
JUN_RAT / P17325 Transcription factor Jun; Activator protein 1; AP1; Proto-oncogene c-Jun; Transcription factor AP-1 subunit Jun; V-jun avian sarcoma virus 17 oncogene homolog from Rattus norvegicus (Rat) (see 3 papers)
NP_068607 transcription factor Jun from Rattus norvegicus
98% identity, 17% coverage
- function: Transcription factor that recognizes and binds to the AP-1 consensus motif 5'-TGA[GC]TCA-3' (By similarity). Heterodimerizes with proteins of the FOS family to form an AP-1 transcription complex, thereby enhancing its DNA binding activity to the AP-1 consensus sequence 5'-TGA[GC]TCA-3' and enhancing its transcriptional activity (By similarity). Together with FOSB, plays a role in activation-induced cell death of T cells by binding to the AP-1 promoter site of FASLG/CD95L, and inducing its transcription in response to activation of the TCR/CD3 signaling pathway (By similarity). Promotes activity of NR5A1 when phosphorylated by HIPK3 leading to increased steroidogenic gene expression upon cAMP signaling pathway stimulation. Involved in activated KRAS-mediated transcriptional activation of USP28. Binds to the USP28 promoter (By similarity).
subunit: Heterodimer with either BATF3 or ATF7 (PubMed:9154808). Heterodimer with FOS (By similarity). Heterodimer with FOSB (By similarity). Component of an AP-1 transcription factor complex composed of JUN-FOS heterodimers (By similarity). As part of the AP-1 transcription factor complex, forms heterodimers with FOSB, thereby binding to the AP-1 consensus sequence and stimulating transcription (By similarity). Interacts with FOS and FOSB (By similarity). The ATF7/JUN heterodimer is essential for ATF7 transactivation activity. Interacts with MYBBP1A, SP1, SPIB and TCF20. Interacts with COPS5; indirectly leading to its phosphorylation. Interacts with TSC22D3 (via N-terminus); this interaction inhibits the binding of active AP1 to its target DNA. Interacts with HIVEP3. Component of the SMAD3/SMAD4/JUN/FOS/complex which forms at the AP1 promoter site. The SMAD3/SMAD4 heterodimer acts synergistically with the JUN/FOS heterodimer to activate transcription in response to TGF-beta. Interacts (via its basic DNA binding and leucine zipper domains) with SMAD3 (via an N-terminal domain); the interaction is required for TGF- beta-mediated transactivation of the SMAD3/SMAD4/JUN/FOS/complex (By similarity). Binds to HIPK3 (By similarity). Interacts with methylated RNF187 (PubMed:20852630). Interacts (when phosphorylated) with FBXW7 (By similarity). Interacts with PRR7 (PubMed:27458189). Found in a complex with PRR7 and FBXW7 (By similarity). Interacts with PRR7 and FBXW7; the interaction inhibits ubiquitination-mediated JUN degradation promoting its phosphorylation and transcriptional activity (By similarity). Interacts with RBM39 (By similarity). Interacts with PAGE4 (By similarity). Interacts with ARK2N and CSNK2B; the interaction with ARK2N is mediated by CSNK2B (By similarity). - RING Finger Protein 10 Regulates AP-1/Meox2 to Mediate Pirarubicin-Induced Cardiomyocyte Apoptosis.
Shi, Oxidative medicine and cellular longevity 2023 - GeneRIF: RING Finger Protein 10 Regulates AP-1/Meox2 to Mediate Pirarubicin-Induced Cardiomyocyte Apoptosis.
- JUN Regulation of Injury-Induced Enhancers in Schwann Cells.
Ramesh, The Journal of neuroscience : the official journal of the Society for Neuroscience 2022 - GeneRIF: JUN Regulation of Injury-Induced Enhancers in Schwann Cells.
- Pemafibrate prevents retinal neuronal cell death in NMDA-induced excitotoxicity via inhibition of p-c-Jun expression.
Fujita, Molecular biology reports 2021 - GeneRIF: Pemafibrate prevents retinal neuronal cell death in NMDA-induced excitotoxicity via inhibition of p-c-Jun expression.
- The role of transcription factor Ap1 in the activation of the Nrf2/ARE pathway through TET1 in diabetic nephropathy.
Tan, Cell biology international 2021 (PubMed)- GeneRIF: The role of transcription factor Ap1 in the activation of the Nrf2/ARE pathway through TET1 in diabetic nephropathy.
- Upregulation of Mlxipl induced by cJun in the spinal dorsal horn after peripheral nerve injury counteracts mechanical allodynia by inhibiting neuroinflammation.
Zhan, Aging 2020 - GeneRIF: Upregulation of Mlxipl induced by cJun in the spinal dorsal horn after peripheral nerve injury counteracts mechanical allodynia by inhibiting neuroinflammation.
- c-Jun promotes the survival of H9c2 cells under hypoxia via PTEN/Akt signaling pathway.
Wu, Journal of physiology and biochemistry 2019 (PubMed)- GeneRIF: The authors show that c-Jun protected H9c2 cells from apoptosis and promoted the survival of H9c2 cells under hypoxia via PTEN/Akt signaling pathway.
- Arthropod transcriptional activator protein-1 (AP-1) aids tick-rickettsial pathogen survival in the cold
Khanal, Scientific reports 2018 - “...Mus musculus (house mouse, GenBank acc. no. NP_034721) and Rattus norvegicus (rat, GenBank acc. no. NP_068607) AP-1 and 44% with Macaca mulatta (Rhesus monkey) AP-1 (GenBank acc. no. NP_001252779) and 46% with Homo sapiens (human) AP-1 (GenBank acc. no. NP_002219) orthologs (Fig. 2B ). ClustalW alignment...”
- “...ricinus AP-1), JAC33128 ( A . triste AP-1), AIT40211 ( R . microplus c-Jun AP-1), NP_068607 ( R . norvegicus AP-1), NP_034721 ( M . musculus AP-1), NP_001252779 ( M . mulatta AP-1) and NP_002219 ( H . sapiens AP-1). Statistics Statistical analysis was performed using...”
- Stimulation of B-Raf increases c-Jun and c-Fos expression and upregulates AP-1-regulated gene transcription in insulinoma cells.
Langfermann, Molecular and cellular endocrinology 2018 (PubMed)- GeneRIF: stimulation of B-Raf strongly activated the transcription factor AP-1 which is accompanied by increased c-Jun and c-Fos promoter activities, an upregulation of c-Jun and c-Fos biosynthesis, and elevated transcriptional activation potentials of c-Jun and c-Fos.
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- A microarray study of gene and protein regulation in human and rat brain following middle cerebral artery occlusion.
Mitsios, BMC neuroscience 2007 - “...Gene name GenBank SwissProt GenBank SwissProt Max/min Days Max/min Time c-jun proto-oncogene J04111 P05412 X17163 P17325 4.4-fold 9 20 3.5-fold 1 h 24 h Matrix metalloproteinase 11 X57766 P24347 U46034 P97568 3.2-fold 2 20 2.6-fold 3 days Calcium/calmodulin-dependent kinase (CAMK1) L41816 Q14012 L24907 Q63450 17.2-fold 2...”
JUN_HUMAN / P05412 Transcription factor Jun; Activator protein 1; AP1; Proto-oncogene c-Jun; Transcription factor AP-1 subunit Jun; V-jun avian sarcoma virus 17 oncogene homolog; p39 from Homo sapiens (Human) (see 30 papers)
NP_002219 transcription factor Jun from Homo sapiens
98% identity, 18% coverage
- function: Transcription factor that recognizes and binds to the AP-1 consensus motif 5'-TGA[GC]TCA-3' (PubMed:10995748, PubMed:22083952). Heterodimerizes with proteins of the FOS family to form an AP-1 transcription complex, thereby enhancing its DNA binding activity to the AP-1 consensus sequence 5'-TGA[GC]TCA-3' and enhancing its transcriptional activity (By similarity). Together with FOSB, plays a role in activation-induced cell death of T cells by binding to the AP-1 promoter site of FASLG/CD95L, and inducing its transcription in response to activation of the TCR/CD3 signaling pathway (PubMed:12618758). Promotes activity of NR5A1 when phosphorylated by HIPK3 leading to increased steroidogenic gene expression upon cAMP signaling pathway stimulation (PubMed:17210646). Involved in activated KRAS-mediated transcriptional activation of USP28 in colorectal cancer (CRC) cells (PubMed:24623306). Binds to the USP28 promoter in colorectal cancer (CRC) cells (PubMed:24623306).
function: (Microbial infection) Upon Epstein-Barr virus (EBV) infection, binds to viral BZLF1 Z promoter and activates viral BZLF1 expression.
subunit: Heterodimer with either BATF3 or ATF7 (PubMed:10376527, PubMed:12087103, PubMed:15467742). Heterodimer with FOS (By similarity). Heterodimer with FOSB isoform 1 and 2 (By similarity). Component of an AP-1 transcription factor complex composed of JUN-FOS heterodimers (By similarity). As part of the AP-1 transcription factor complex, forms heterodimers with FOSB, thereby binding to the AP-1 consensus sequence and stimulating transcription (By similarity). Interacts with FOS and FOSB isoform 1 and 2 (By similarity). The ATF7/JUN heterodimer is essential for ATF7 transactivation activity (PubMed:10376527). Interacts with TSC22D3 (via N-terminus); the interaction inhibits the binding of active AP1 to its target DNA (By similarity). Interacts with HIVEP3 and MYBBP1A (By similarity). Interacts with SP1, SPIB and TCF20 (PubMed:10196196, PubMed:16478997, PubMed:8663478). Interacts with COPS5; the interaction leads indirectly to its phosphorylation (PubMed:8837781). Component of the SMAD3/SMAD4/JUN/FOS/complex which forms at the AP1 promoter site (PubMed:10995748). The SMAD3/SMAD4 heterodimer acts synergistically with the JUN/FOS heterodimer to activate transcription in response to TGF-beta (PubMed:9732876). Interacts (via its basic DNA binding and leucine zipper domains) with SMAD3 (via an N-terminal domain); the interaction is required for TGF-beta-mediated transactivation of the SMAD3/SMAD4/JUN/FOS/complex (PubMed:10995748). Interacts with methylated RNF187 (PubMed:20852630, PubMed:23624934). Binds to HIPK3. Interacts (when phosphorylated) with FBXW7 (PubMed:14739463). Found in a complex with PRR7 and FBXW7 (PubMed:27458189). Interacts with PRR7 and FBXW7; the interaction inhibits ubiquitination-mediated JUN degradation promoting its phosphorylation and transcriptional activity (PubMed:27458189). Interacts with RBM39 (By similarity). Interacts with PAGE4 (PubMed:24263171, PubMed:24559171, PubMed:26242913). Interacts with ARK2N and CSNK2B; the interaction with ARK2N is mediated by CSNK2B (PubMed:31341047). - Knockdown of BUB1B Inhibits the Proliferation, Migration, and Invasion of Colorectal Cancer by Regulating the JNK/c-Jun Signaling Pathway.
Zeng, Cancer biotherapy & radiopharmaceuticals 2024 (PubMed)- GeneRIF: Knockdown of BUB1B Inhibits the Proliferation, Migration, and Invasion of Colorectal Cancer by Regulating the JNK/c-Jun Signaling Pathway.
- Inhibition of ATM promotes PD-L1 expression by activating JNK/c-Jun/TNF-α signaling axis in triple-negative breast cancer.
Liu, Cancer letters 2024 (PubMed)- GeneRIF: Inhibition of ATM promotes PD-L1 expression by activating JNK/c-Jun/TNF-alpha signaling axis in triple-negative breast cancer.
- ANKRD1 is a mesenchymal-specific driver of cancer-associated fibroblast activation bridging androgen receptor loss to AP-1 activation.
Mazzeo, Nature communications 2024 - GeneRIF: ANKRD1 is a mesenchymal-specific driver of cancer-associated fibroblast activation bridging androgen receptor loss to AP-1 activation.
- Single cell RNA-seq identifies a FOS/JUN-related monocyte signature associated with clinical response of heart failure patients with mesenchymal stem cell therapy.
Yuan, Aging 2024 - GeneRIF: Single cell RNA-seq identifies a FOS/JUN-related monocyte signature associated with clinical response of heart failure patients with mesenchymal stem cell therapy.
- SIAH2 suppresses c-JUN pathway by promoting the polyubiquitination and degradation of HBx in hepatocellular carcinoma.
Hu, Journal of cellular and molecular medicine 2024 - GeneRIF: SIAH2 suppresses c-JUN pathway by promoting the polyubiquitination and degradation of HBx in hepatocellular carcinoma.
- FOXA2 rewires AP-1 for transcriptional reprogramming and lineage plasticity in prostate cancer.
Wang, Nature communications 2024 - GeneRIF: FOXA2 rewires AP-1 for transcriptional reprogramming and lineage plasticity in prostate cancer.
- The Role of Activator Protein-1 Complex in Diabetes-Associated Atherosclerosis: Insights From Single-Cell RNA Sequencing.
Khan, Diabetes 2024 (PubMed)- GeneRIF: The Role of Activator Protein-1 Complex in Diabetes-Associated Atherosclerosis: Insights From Single-Cell RNA Sequencing.
- Interferon subverts an AHR-JUN axis to promote CXCL13+ T cells in lupus.
Law, Nature 2024 - GeneRIF: Interferon subverts an AHR-JUN axis to promote CXCL13[+] T cells in lupus.
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- The mechanism of Weiqi decoction treating gastric cancer: a work based on network pharmacology and experimental verification
Huang, Hereditas 2025 (no snippet) - Bioinformatics Approach to Identifying Molecular Targets of Isoliquiritigenin Affecting Chronic Obstructive Pulmonary Disease: A Machine Learning Pharmacology Study
Huang, International journal of molecular sciences 2025 - Mechanistic Insights Into <i>Ganoderma Lucidum</i> for Diabetes Treatment via Network Pharmacology and Validation
Guo, Diabetes, metabolic syndrome and obesity : targets and therapy 2025 (no snippet) - Innovative Application of Medicinal Insects: Employing UHPLC-MS, Bioinformatics, In Silico Studies and <i>In Vitro</i> Experiments to Elucidate the Multi-Target Hemostatic Mechanism of <i>Glenea cantor</i> (Coleoptera: Cerambycidae) Charcoal-Based Medicine
Zhong, Pharmaceuticals (Basel, Switzerland) 2025 (no snippet) - Combining Experimental Validation and Network Pharmacology to Reveal the Action Mechanism of Panax Notoginseng-Radix Salviae on Atherosclerosis
Song, Journal of inflammation research 2025 - “...the PPI Network Gene names UniProt ID Protein Names RELA Q04206 Transcription factor p65 JUN P05412 Transcription factor Jun TNF P01375 Tumor necrosis factor IL6 P05231 Interleukin-6 IL1B P01584 Interleukin-1 beta IL1A P01583 Interleukin-1 alpha CCL2 P13500 C-C motif chemokine 2 CXCL8 P10145 Interleukin-8 IL4 p05112...”
- Kaempferol Mitigates <i>Pseudomonas aeruginosa</i>-Induced Acute Lung Inflammation Through Suppressing GSK3β/JNK/c-Jun Signaling Pathway and NF-κB Activation
Wang, Pharmaceuticals (Basel, Switzerland) 2025 - “...EGFR 52 3 P31749 AKT1 51 4 P10415 BCL2 50 5 P14780 MMP9 49 6 P05412 JUN 47 7 P42574 CASP3 47 8 P12931 SRC 45 9 P35354 PTGS2 45 10 P03372 ESR1 44 11 P07900 HSP90AA1 43 12 P37231 PPARG 42 13 P49841 GSK3B 38...”
- The Potential of Siraitia grosvenorii to Promote Bone Regeneration via Modulating Macrophage Polarization: A Network Pharmacology and Experimental Study
Mai, International journal of molecular sciences 2025 - Exploring the mechanism of action of Lobetyolin in the treatment of allergic rhinitis based on network pharmacology and molecular docking
Hou, Medicine 2025 - “...CMA1 Chymase 1 P23946 12 TNF Tumor necrosis factor P01375 13 JUN Transcription factor AP-1 P05412 14 CHRM4 Muscarinic acetylcholine receptor M4 P08173 15 CHRM5 Muscarinic acetylcholine receptor M5 P08912 16 CHRM2 Muscarinic acetylcholine receptor M2 P08172 17 CHRM3 Muscarinic acetylcholine receptor M3 P20309 18 CHIA...”
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P56432 Transcription factor Jun from Sus scrofa
NP_999045 transcription factor AP-1 from Sus scrofa
98% identity, 18% coverage
NP_001071295 transcription factor Jun from Bos taurus
98% identity, 19% coverage
NP_001026460 transcription factor AP-1 from Gallus gallus
98% identity, 18% coverage
JUN_CHICK / P18870 Transcription factor Jun; Proto-oncogene c-Jun; Transcription factor AP-1 subunit Jun from Gallus gallus (Chicken) (see paper)
98% identity, 18% coverage
- function: Transcription factor that recognizes and binds to the enhancer heptamer motif 5'-TGA[CG]TCA-3'. May be involved in activated KRAS-mediated transcriptional activation of USP28. May bind to the USP28 promoter.
subunit: Interacts with FOS to form a dimer. Interacts with Gallid herpesvirus 2 MEQ protein. - Baicalin inhibits inflammation caused by coinfection of Mycoplasma gallisepticum and Escherichia coli involving IL-17 signaling pathway
Wu, Poultry science 2020 - “...2018 ). The UniProtKB IDs were as follows: TRAF6, E1C626; CIKS, F1NQU5; NF-B, Q04861; AP-1, P18870; and C/EBP, Q05826. As the 3D structure of these 5 proteins ( Gallus gallus ) has not been elucidated yet, method of comparative modeling was used for their 3D structure....”
P54864 Transcription factor Jun from Serinus canaria
98% identity, 18% coverage
- The Stress Response of the Holothurian Central Nervous System: A Transcriptomic Analysis.
Cruz-González, International journal of molecular sciences 2022 - “...metabolism Upregulated NEURL1 Q0MW30 E3 ubiquitin ligase Upregulated HSPA2 P54652 Unfolded protein binding Upregulated JUN P54864 Transcription factor Upregulated CBLIF P27352 Cobalamin binding Downregulated RPS5 P46782 Structural constituent of ribosome Downregulated MRPL12 Q7YR75 Structural constituent of ribosome Downregulated SPDEF O95238 Transcription factor Downregulated DMBT1 Q9UGM3 DNA...”
LOC100703685 transcription factor AP-1 from Oreochromis niloticus
95% identity, 18% coverage
5t01A / P05412 Human c-jun DNA binding domain homodimer in complex with methylated DNA (see paper)
100% identity, 94% coverage
NP_956281 transcription factor AP-1 from Danio rerio
93% identity, 19% coverage
NP_001084266 jun proto-oncogene L homeolog from Xenopus laevis
91% identity, 18% coverage
NP_001087435 jun D proto-oncogene S homeolog from Xenopus laevis
88% identity, 19% coverage
JUND_HUMAN / P17535 Transcription factor JunD; Transcription factor AP-1 subunit JunD from Homo sapiens (Human) (see 3 papers)
NP_005345 transcription factor JunD isoform JunD-FL from Homo sapiens
86% identity, 17% coverage
- function: Transcription factor binding AP-1 sites (PubMed:9989505). Heterodimerizes with proteins of the FOS family to form an AP-1 transcription factor complex, thereby enhancing their DNA binding activity to an AP-1 consensus sequence 3'-TGA[GC]TCA-5' and enhancing their transcriptional activity (PubMed:28981703, PubMed:9989505).
subunit: Heterodimer; binds DNA as a heterodimer (PubMed:28981703). Component of an AP-1 transcription factor complex composed of JUN-FOS heterodimers (By similarity). As part of the AP-1 transcription factor complex, forms heterodimers with FOS proteins, thereby binding to the AP-1 consensus sequence and stimulating transcription (By similarity). Forms heterodimers with FOSB; thereby binding to the AP-1 consensus sequence (PubMed:28981703). Interacts (via MBM motif) with MEN1; this interaction represses transcriptional activation (PubMed:22327296, PubMed:9989505). Interacts with MAPK10; this interaction is inhibited in the presence of MEN1 (PubMed:22327296). - JUND facilitates proliferation and angiogenesis of esophageal squamous cell carcinoma cell via MAPRE2 up-regulation.
Zhang, Tissue & cell 2023 (PubMed)- GeneRIF: JUND facilitates proliferation and angiogenesis of esophageal squamous cell carcinoma cell via MAPRE2 up-regulation.
- USP7-mediated JUND suppresses RCAN2 transcription and elevates NFATC1 to enhance stem cell property in colorectal cancer.
Chang, Cell biology and toxicology 2023 (PubMed)- GeneRIF: USP7-mediated JUND suppresses RCAN2 transcription and elevates NFATC1 to enhance stem cell property in colorectal cancer.
- AP-1 transcription factors in cytotoxic lymphocyte development and antitumor immunity.
Schnoegl, Current opinion in immunology 2023 (PubMed)- GeneRIF: AP-1 transcription factors in cytotoxic lymphocyte development and antitumor immunity.
- JUND-dependent up-regulation of HMOX1 is associated with cisplatin resistance in muscle-invasive bladder cancer.
Peng, Journal of biochemistry 2020 (PubMed)- GeneRIF: JUND-dependent up-regulation of HMOX1 is associated with cisplatin resistance in muscle-invasive bladder cancer.
- The mRNA encoding the JUND tumor suppressor detains nuclear RNA-binding proteins to assemble polysomes that are unaffected by mTOR.
Singh, The Journal of biological chemistry 2020 - GeneRIF: The mRNA encoding the JUND tumor suppressor detains nuclear RNA-binding proteins to assemble polysomes that are unaffected by mTOR.
- LncRNA LOXL1-AS1 is transcriptionally activated by JUND and contributes to osteoarthritis progression via targeting the miR-423-5p/KDM5C axis.
Chen, Life sciences 2020 (PubMed)- GeneRIF: LncRNA LOXL1-AS1 is transcriptionally activated by JUND and contributes to osteoarthritis progression via targeting the miR-423-5p/KDM5C axis.
- Immediate-Early Promoter-Driven Transgenic Reporter System for Neuroethological Research in a Hemimetabolous Insect
Watanabe, eNeuro 2018 - “...D. melanogaster Jra, NP_476586; H. sapience c-Jun, NP_002219; H. sapience Jun-B, NP_002220; H. sapience Jun-D, NP_005345. Download Figure 1-3, EPS file . 10.1523/ENEURO.0061-18.2018.f1-4 Figure 1-4 Gryllus egr gene encodes a protein closely related to insect and vertebrate Egr-1 homologs. A , Protein domain structures of Gryllus...”
- HBZ-mediated shift of JunD from growth suppressor to tumor promoter in leukemic cells by inhibition of ribosomal protein S25 expression.
Terol, Leukemia 2017 (PubMed)- GeneRIF: In T cells, after serum deprivation HBZ induces the expression of Delta JunD isoform. Unlike JunD, Delta JunD induces proliferation and transformation of cells. HBZ bypasses translational control of JunD uORF and favors the expression of Delta JunD. The truncated isoform Delta JunD has a central role in the oncogenic process leading to adult T-cell leukemia .
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- Assessing the Validity of Leucine Zipper Constructs Predicted in AlphaFold2
Mitic, 2024 - Blood Plasma Circulating DNA-Protein Complexes: Involvement in Carcinogenesis and Prospects for Liquid Biopsy of Breast Cancer.
Shefer, Journal of personalized medicine 2023 - “...66 Q7Z422 SUZ domain-containing protein 1 SZRD1 58 Q9H2G4 Testis-specific Y-encoded-like protein 2 TSPYL2 79 P17535 Transcription factor jun-D JUND 68 + Q15629 Translocating chain-associated membrane protein 1 TRAM1 73 Q8N609 Translocating chain-associated membrane protein 1-like 1 TRAM1L1 62 + Q9UPT9 Ubiquitin carboxyl-terminal hydrolase 22 UBP22...”
- “...O75912 O95236 O95260 O95837 O96004 O96020 P02795 P06858 P08311 P08588 P11233 P14316 P15692 P17482 P17483 P17535 P17812 P17987 P20592 P23443 P23942 P24844 P29371 P29466 P31271 P34896 P43487 P46777 P48163 P48995 P49137 P49757 P50454 P51665 P55010 P60059 P60608 P62314 Q01081 Q02108 Q03060 Q03252 Q05215 Q06416 Q13033 Q13111...”
- In silico structural analysis of sequences containing 5-hydroxymethylcytosine reveals its potential as binding regulator for development, ageing and cancer-related transcription factors.
Malousi, Epigenetics 2021 - Computational and In Vitro Analysis of Plumbagin's Molecular Mechanism for the Treatment of Hepatocellular Carcinoma.
Wei, Frontiers in pharmacology 2021 - “...factor NF-kappa-B p65 subunit RELA Q04206 Transcription factor AP-1 JUN P05412 Transcription factor jun-D JUND P17535 Estrogen receptor, ER ESR1 P03372 Dual specificity mitogen-activated protein kinase kinase 4 MAP2K4 P45985 Signal transducer and activator of transcription 3 STAT3 P40763 Tyrosine-protein phosphatase non-receptor type 1 PTPN1 P18031...”
- Unveiling the Mechanism of Principal Drugs of Lianpu Drink on Chronic Gastritis by Network Pharmacology.
Zhou, Evidence-based complementary and alternative medicine : eCAM 2021 - “...name Closeness centrality Degree Betweenness centrality P41182 B-cell lymphoma 6 protein BCL6 0.2056 8 0.0369 P17535 Transcription factor jun-D JUND 0.1857 4 0.0023 P15941 Mucin-1 MUC1 0.2361 3 0.0339 Q14164 Inhibitor of nuclear factor kappa-B kinase subunit epsilon IKBKE 0.1967 5 0.0052 Q16539 Mitogen-activated protein kinase...”
- Cytosolic phospholipase A2α modulates cell-matrix adhesion via the FAK/paxillin pathway in hepatocellular carcinoma.
Guo, Cancer biology & medicine 2019 - “...P05412, Q01201, P16949, Q04206, P45985, Q16539, P04792, P49407, P11362, O14920, P17252, Q02750, O15111, P09619, P31751, P17535, P01106, Q12968, P11831, P01100, P46108, Q9Y6K9, P46734, P41279, P10636, P18848, Q13972, P15336, P19838, Q13177, P04049, Q16620, Q06413, P42574, O75582, O14733, P00533, P31749 2.12E-24 hsa05205:proteoglycans in cancer 50 5.08E-28 P24385, P12931,...”
- “...1.81E-21 P17275, P06239, P42224, P07333, O14920, Q02750, Q06187, O75030, O15111, O43318, Q13094, P16885, P43405, P31751, P17535, P37231, P01100, Q9Y6K9, P15260, Q9UQC2, P23458, P25963, P19838, P05106, Q16566, Q8WV28, P16220, P63000, P05412, Q01201, P52630, Q04206, Q16539, P53539, O14733, P31749 2.27E-18 hsa04660:T cell receptor signaling pathway 33 6.49E-22 P20963,...”
- A census of P. longum's phytochemicals and their network pharmacological evaluation for identifying novel drug-like molecules against various diseases, with a special focus on neurological disorders
Choudhary, PloS one 2018 - “...Q15759, O15264, P53779, Q8TD08, P45984, Q16659, P45983, P35354, Q13164, Q14790, P45452, P08254, P03956, P42574, P53778, P17535, P05412, Q04206, P49841, P28482, P31152, P04141, P01100, P27361, P13500, P25963. Th1 and Th2 cell differentiation path:hsa04658 18 O14920, P60568, P19838, P06239, Q16539, Q15759, O15264, P53779, P45984, P45983, P53778, P05412, Q04206,...”
- MiR-206 is expressed in pancreatic islets and regulates glucokinase activity.
Vinod, American journal of physiology. Endocrinology and metabolism 2016 - “...Symbol Name Q92922 SMARCC1 SWI/SNF complex subunit SMARCC1 Q16875 PFKFB3 6-Phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 P53539 FOSB ProteinfosB P17535 JUND Transcription factor jun-D Q9UGR2 ZC3H7B Zinc finger CCCH domain-containing protein 7B Q92841 DDX17 Probable ATP-dependent RNA helicase DDX17 O14617 AP3D1 AP-3 complex subunit-1 P24385 CCND1 G1/S-specific cyclin-D1 O95544 NADK...”
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P52909 Transcription factor JunD from Rattus norvegicus
NP_620230 transcription factor JunD isoform JunD-FL from Rattus norvegicus
86% identity, 17% coverage
- Peptidomic profiles of post myocardial infarction rats affinity depleted plasma using matrix-assisted laser desorption/ionization time of flight (MALDI-ToF) mass spectrometry.
Wang, Clinical and translational medicine 2012 - “...(%) 1955.9184 Q63537 SYN2_RAT Synapsin-2 33 2041.0374 P70478 APC_RAT Adenomatous polyposis coli protein 81 2041.023 P52909 JUND_RAT Transcription factor jun-D 98.6 2799.3203 Q68FU4 CG010_RAT CaiB/baiF CoA-transferase family protein C7orf10 homolog 43.5 3488.7876 P51657 DHB1_RAT Estradiol 17-beta-dehydrogenase 1 34 3503.7307 P05545 CPI1_RAT Contrapsin-like protease inhibitor 1 precursor...”
- JunD enhances miR-29b levels transcriptionally and posttranscriptionally to inhibit proliferation of intestinal epithelial cells.
Zou, American journal of physiology. Cell physiology 2015 - GeneRIF: JunD activates miR-29b by enhancing its transcription and processing, which contribute to the inhibitory effect of JunD
- Selective up-regulation of JunD transcript and protein expression in vasopressinergic supraoptic nucleus neurones in water-deprived rats.
Yao, Journal of neuroendocrinology 2012 - GeneRIF: JunD is highly co-expressed with c-Fos in magnocellular neurons of the supraoptic nucleus following dehydration.
- Induced ATF-2 represses CDK4 transcription through dimerization with JunD inhibiting intestinal epithelial cell growth after polyamine depletion.
Xiao, American journal of physiology. Cell physiology 2010 - GeneRIF: These results indicate that induced ATF-2/JunD association following polyamine depletion represses CDK4 transcription, thus contributing to the inhibition of intestinal epithelial cell growth.
- Jund is a determinant of macrophage activation and is associated with glomerulonephritis susceptibility.
Behmoaras, Nature genetics 2008 - GeneRIF: JunD is a major determinant of macrophage activity and is associated with glomerulonephritis susceptibility.
- Induced JunD in intestinal epithelial cells represses CDK4 transcription through its proximal promoter region following polyamine depletion.
Xiao, The Biochemical journal 2007 - GeneRIF: JunD bound to the proximal region of the CDK4-promoter in vitro as well as in vivo. transcriptional repression of CDK4 by JunD was mediated through an AP-1 binding site within this proximal sequence of the CDK4-promoter.
- Heterodimerization with Jun family members regulates c-Fos nucleocytoplasmic traffic.
Malnou, The Journal of biological chemistry 2007 (PubMed)- GeneRIF: Dimerization with the Jun proteins inhibits c-Fos nuclear exit.
- Fos- and Jun-related transcription factors are involved in the signal transduction pathway of mechanical loading in condylar chondrocytes.
Papachristou, European journal of orthodontics 2006 (PubMed)- GeneRIF: plays key role in remodelling phenomena of bone and cartilage
- Translational regulation of the JunD messenger RNA.
Short, The Journal of biological chemistry 2002 (PubMed)- GeneRIF: Translation initiation from alternative AUG and non-AUG sites in human, mouse and rat.
JUND_MOUSE / P15066 Transcription factor JunD; Transcription factor AP-1 subunit JunD from Mus musculus (Mouse) (see paper)
NP_034722 transcription factor JunD isoform JunD-FL from Mus musculus
86% identity, 17% coverage
- function: Transcription factor binding AP-1 sites (By similarity). Heterodimerizes with proteins of the FOS family to form an AP-1 transcription factor complex, thereby enhancing its DNA binding activity to an AP-1 consensus sequence 3'-TGA[GC]TCA-5' and enhancing its transcriptional activity (By similarity).
subunit: Heterodimer; binds DNA as a heterodimer (By similarity). Component of an AP-1 transcription factor complex composed of JUN-FOS heterodimers (By similarity). As part of the AP-1 transcription factor complex, forms heterodimers with FOS proteins, thereby binding to the AP-1 consensus sequence and stimulating transcription (By similarity). Forms heterodimers with FOSB; thereby binding to the AP-1 consensus sequence (By similarity). Interacts (via MBM motif) with MEN1; this interaction represses transcriptional activation (PubMed:9989505). Interacts with MAPK10; this interaction is inhibited in the presence of MEN1 (By similarity). - Using CRISPR-Cas9/phosphoproteomics to identify substrates of calcium/calmodulin-dependent kinase 2δ.
Park, The Journal of biological chemistry 2023 - “...Q6ZPV2 Ino80 DNA helicase INO80 S470 HQA R TR S F D EDAK 0.43 0.0000 P15066 Jund Transcription factor AP-1; transcription factor jun-D S100 GLL K LA S P E LERL 0.68 0.0000 Q5SVQ0 Kat7 Histone acetyltransferase KAT7 S228 CKV R AQ S R D KQIE...”
- Protein kinase A catalytic-α and catalytic-β proteins have nonredundant regulatory functions
Raghuram, American journal of physiology. Renal physiology 2020 (secret) - The MEKK1 SWIM domain is a novel substrate receptor for c-Jun ubiquitylation.
Rieger, The Biochemical journal 2012 - “...in c-Jun. UniProt accession numbers for the sequences are as follows: P05627 (c-Jun), P09450 (JunB), P15066 (JunD), P01101 (c-Fos), and P47930 (Fra2). ( C ) GST-SWIM pulldown assay using c-Jun and mutant c-Jun proteins from transfected 293T cells. The upper panel shows an anti-FLAG immunoblot of...”
- JunD Regulates Pancreatic β-Cells Function by Altering Lipid Accumulation.
Wang, Frontiers in endocrinology 2021 - GeneRIF: JunD Regulates Pancreatic beta-Cells Function by Altering Lipid Accumulation.
- Cardiomyocyte-Specific JunD Overexpression Increases Infarct Size following Ischemia/Reperfusion Cardiac Injury by Downregulating Sirt3.
Akhmedov, Thrombosis and haemostasis 2020 (PubMed)- GeneRIF: this study shows that cardiomyocyte-specific JunD overexpression increases infarct size following ischemia/reperfusion cardiac injury by downregulating Sirt3
- Rutin protects against pirarubicin-induced cardiotoxicity by adjusting microRNA-125b-1-3p-mediated JunD signaling pathway.
Li, Molecular and cellular biochemistry 2020 (PubMed)- GeneRIF: Rutin protects against pirarubicin-induced cardiotoxicity by adjusting microRNA-125b-1-3p-mediated JunD signaling pathway.
- Hyperglycemia Induces Myocardial Dysfunction via Epigenetic Regulation of JunD.
Hussain, Circulation research 2020 (PubMed)- GeneRIF: Hyperglycemia Induces Myocardial Dysfunction via Epigenetic Regulation of JunD.
- AP-1 (Activated Protein-1) Transcription Factor JunD Regulates Ischemia/Reperfusion Brain Damage via IL-1β (Interleukin-1β).
Diaz-Cañestro, Stroke 2019 (PubMed)- GeneRIF: JunD blunts ischemia/reperfusion-induced brain injury via suppression of IL-1beta.
- Obesity-induced activation of JunD promotes myocardial lipid accumulation and metabolic cardiomyopathy.
Costantino, European heart journal 2019 (PubMed)- GeneRIF: Obesity-induced activation of JunD promotes myocardial lipid accumulation and metabolic cardiomyopathy.
- AP-1-mediated expression of brain-specific class IVa β-tubulin in P19 embryonal carcinoma cells.
Maruyama, The Journal of veterinary medical science 2014 - GeneRIF: Differentiation-mediated activation of JunD results in enhanced TUBB4a expression in P19 embryonal carcinoma cells.
- Transcriptional regulation of the mouse CD11c promoter by AP-1 complex with JunD and Fra2 in dendritic cells.
Hara, Molecular immunology 2013 (PubMed)- GeneRIF: AP-1 composed with JunD and Fra2 protein plays a primary role in enhancing the transcription level of the CD11c gene in dendritic cells
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NP_001096723 transcription factor JunD from Bos taurus
86% identity, 17% coverage
NP_068608 transcription factor JunB from Rattus norvegicus
81% identity, 17% coverage
- MicroRNA 199a-5p induces apoptosis by targeting JunB.
Yan, Scientific reports 2018 - GeneRIF: Based on these findings, miR-199a-5p induces apoptosis by targeting JunB.
- JunB is a repressor of MMP-9 transcription in depolarized rat brain neurons.
Rylski, Molecular and cellular neurosciences 2009 (PubMed)- GeneRIF: This study documents the active repressive influence of AP-1 onto MMP-9 transcriptional regulation by the engagement of JunB.
- Time-course of immediate early gene expression in hippocampal subregions of adrenalectomized rats after acute corticosterone challenge.
Hansson, Brain research 2008 - GeneRIF: Corticosterone treatment gave rise to a delayed and significant reduction of junB mRNA signals after 2 h in all hippocampal regions, which reversed to increase at 4 h.
- Heterodimerization with Jun family members regulates c-Fos nucleocytoplasmic traffic.
Malnou, The Journal of biological chemistry 2007 (PubMed)- GeneRIF: Dimerization with the Jun proteins inhibits c-Fos nuclear exit.
- Fos- and Jun-related transcription factors are involved in the signal transduction pathway of mechanical loading in condylar chondrocytes.
Papachristou, European journal of orthodontics 2006 (PubMed)- GeneRIF: plays key role in remodelling phenomena of bone and cartilage
- Expressions of junB and c-fos are enhanced in 4-nitroquinoline 1-oxide-induced rat tongue cancers.
Ohyama, Pathology international 2004 (PubMed)- GeneRIF: Expressions of junB and c-fos were enhanced stepwise in 4NQO-induced carcinogenesis of rat tongue.
- Expression of c-Fos, ICER, Krox-24 and JunB in the whisker-to-barrel pathway of rats: time course of induction upon whisker stimulation by tactile exploration of an enriched environment.
Bisler, Journal of chemical neuroanatomy 2002 (PubMed)- GeneRIF: upon whisker stimulation by exploration of a novel, enriched environment, in the barrel cortex JunB, is differentially regulated in the temporal domain
5vpeD / P17535 Transcription factor fosb/jund bzip domain in complex with cognate DNA, type-i crystal (see paper)
86% identity, 87% coverage
JUNB_MOUSE / P09450 Transcription factor JunB; MyD21; Transcription factor AP-1 subunit JunB from Mus musculus (Mouse) (see paper)
NP_032442 transcription factor JunB from Mus musculus
79% identity, 17% coverage
- function: Transcription factor involved in regulating gene activity following the primary growth factor response. Binds to the DNA sequence 5'-TGA[GC]TCA-3'. Heterodimerizes with proteins of the FOS family to form an AP-1 transcription complex, thereby enhancing its DNA binding activity to an AP-1 consensus sequence 5'-TGA[GC]TCA-3' and enhancing its transcriptional activity (PubMed:2498083).
subunit: Binds DNA as a homodimer or as a heterodimer with another member of the Jun/Fos family (By similarity). Component of an AP-1 transcription factor complex composed of JUN-FOS heterodimers (PubMed:2498083). As part of the AP-1 transcription factor complex, forms heterodimers with FOSB, thereby binding to the AP-1 consensus sequence and stimulating transcription (PubMed:2498083). Interacts with NFE2 (via its WW domains) (By similarity). - Norbergenin prevents LPS-induced inflammatory responses in macrophages through inhibiting NFκB, MAPK and STAT3 activation and blocking metabolic reprogramming.
Li, Frontiers in immunology 2023 - “...chemokine 10 -5.978 Down Ccl2 P10148 C-C motif chemokine 2 -4.226 Down TNF-NFB pathway Junb P09450 Transcription factor jun-B -1.937 Down Plek Q9JHK5 Pleckstrin -0.696 Down Tnfaip2 Q61333 Tumor necrosis factor alpha-induced protein 2 -1.515 Down Ifih1 Q8R5F7 Interferon-induced helicase C domain-containing protein 1 -1.914 Down...”
- Cutting Edge: Synchronization of IRF1, JunB, and C/EBPβ Activities during TLR3-TLR7 Cross-Talk Orchestrates Timely Cytokine Synergy in the Proinflammatory Response.
Liu, Journal of immunology (Baltimore, Md. : 1950) 2015 - The MEKK1 SWIM domain is a novel substrate receptor for c-Jun ubiquitylation.
Rieger, The Biochemical journal 2012 - “...for mutagenesis in c-Jun. UniProt accession numbers for the sequences are as follows: P05627 (c-Jun), P09450 (JunB), P15066 (JunD), P01101 (c-Fos), and P47930 (Fra2). ( C ) GST-SWIM pulldown assay using c-Jun and mutant c-Jun proteins from transfected 293T cells. The upper panel shows an anti-FLAG...”
- Directional responses following recombinant cytokine stimulation of rainbow trout (Oncorhynchus mykiss) RTS-11 macrophage cells as revealed by transcriptome profiling.
Martin, BMC genomics 2007 - “...(Asp-Glu-Ala-Asp) box polypeptide 5 P17844 GO:0016049: cell growth 6.8 3.7 CA056715 (3) Transcription factor JUN-B P09450 GO:0045449: regulation of transcription 6.5 0.7 CA063635* Ssa.5016 N/A 6.5 3.4 CB514104 Adipophilin (Adipose differentiation-related protein) P43883 GO:0006810: transport 6.3 0.7 CA038364 Similar to ubiquinol-cytochrome c reductase complex P00130 GO:0044237:...”
- Testosterone suppresses protective responses of the liver to blood-stage malaria.
Krücken, Infection and immunity 2005 - Depletion of JunB increases adipocyte thermogenic capacity and ameliorates diet-induced insulin resistance.
Zhang, Nature metabolism 2024 - GeneRIF: Depletion of JunB increases adipocyte thermogenic capacity and ameliorates diet-induced insulin resistance.
- The transcription factors NR5A1 and JUNB cooperate to activate the Axl promoter in mouse Sertoli cell lines.
Diawara, Molecular biology reports 2024 (PubMed)- GeneRIF: The transcription factors NR5A1 and JUNB cooperate to activate the Axl promoter in mouse Sertoli cell lines.
- The transcription factors Junb and Fosl2 cooperate to regulate Cdh3 expression in 15P-1 Sertoli cells.
Nguyen, Molecular reproduction and development 2023 (PubMed)- GeneRIF: The transcription factors Junb and Fosl2 cooperate to regulate Cdh3 expression in 15P-1 Sertoli cells.
- Integrated analysis reveals Atf3 promotes neuropathic pain via orchestrating JunB mediated release of inflammatory cytokines in DRG macrophage.
Deng, Life sciences 2023 (PubMed)- GeneRIF: Integrated analysis reveals Atf3 promotes neuropathic pain via orchestrating JunB mediated release of inflammatory cytokines in DRG macrophage.
- Shock drives a STAT3 and JunB-mediated coordinated transcriptional and DNA methylation response in the endothelium.
Ramos, Journal of cell science 2023 - GeneRIF: Shock drives a STAT3 and JunB-mediated coordinated transcriptional and DNA methylation response in the endothelium.
- JunB Is Critical for Survival of T Helper Cells.
Hsieh, Frontiers in immunology 2022 - GeneRIF: JunB Is Critical for Survival of T Helper Cells.
- New roles for AP-1/JUNB in cell cycle control and tumorigenic cell invasion via regulation of cyclin E1 and TGF-β2.
Pérez-Benavente, Genome biology 2022 - GeneRIF: New roles for AP-1/JUNB in cell cycle control and tumorigenic cell invasion via regulation of cyclin E1 and TGF-beta2.
- The basal transcriptional activity of the murine Klf10 gene is regulated by the transcriptional factor JunB.
Memon, Genes & genomics 2021 (PubMed)- GeneRIF: The basal transcriptional activity of the murine Klf10 gene is regulated by the transcriptional factor JunB.
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NP_001069124 transcription factor JunB from Bos taurus
81% identity, 17% coverage
JUNB_HUMAN / P17275 Transcription factor JunB; Transcription factor AP-1 subunit JunB from Homo sapiens (Human) (see paper)
Q5U079 Transcription factor JunB from Homo sapiens
NP_002220 transcription factor JunB from Homo sapiens
81% identity, 17% coverage
- function: Transcription factor involved in regulating gene activity following the primary growth factor response. Binds to the DNA sequence 5'-TGA[GC]TCA-3'. Heterodimerizes with proteins of the FOS family to form an AP-1 transcription complex, thereby enhancing its DNA binding activity to an AP-1 consensus sequence and its transcriptional activity (By similarity).
subunit: Binds DNA as a homodimer or as a heterodimer with another member of the Jun/Fos family. Component of an AP-1 transcription factor complex composed of JUN-FOS heterodimers composed of JUN-FOS heterodimers (By similarity). As part of the AP-1 transcription factor complex, forms heterodimers with FOSB, thereby binding to the AP-1 consensus sequence and stimulating transcription (By similarity). Interacts with ITCH (via its WW domains). - Docetaxel Resistance in Castration-Resistant Prostate Cancer: Transcriptomic Determinants and the Effect of Inhibiting Wnt/β-Catenin Signaling by XAV939.
Pudova, International journal of molecular sciences 2022 - “...A6QRI9 181 UBC-201 ENSP00000344818 P0CG48 - 685 SQSTM1-202 ENSP00000374455 Q13501 - 440 JUNB-201 ENSP00000303315 P17275 Q5U079 347 CFL1-201 ENSP00000309629 P23528 V9HWI5 166 TUBB4B-201 ENSP00000341289 P68371 - 445 TUBB-205 ENSP00000339001 P07437 Q5SU16 444 S100A6-201 ENSP00000357708 P06703 - 90 TUBB3-201 ENSP00000320295 Q13509 - 450 ijms-23-12837-t007_Table 7 Table 7...”
- Spatiotemporal Transcriptome Analysis Reveals Activation of the AP1 Pathway in the Ovarian Microenvironment during the Transition from Premenopause to Postmenopause.
Pei, Aging and disease 2024 - GeneRIF: Spatiotemporal Transcriptome Analysis Reveals Activation of the AP1 Pathway in the Ovarian Microenvironment during the Transition from Premenopause to Postmenopause.
- The activator protein-1 complex governs a vascular degenerative transcriptional programme in smooth muscle cells to trigger aortic dissection and rupture.
Luo, European heart journal 2024 (PubMed)- GeneRIF: The activator protein-1 complex governs a vascular degenerative transcriptional programme in smooth muscle cells to trigger aortic dissection and rupture.
- JunB condensation attenuates vascular endothelial damage under hyperglycemic condition.
Ren, Journal of molecular cell biology 2024 - GeneRIF: JunB condensation attenuates vascular endothelial damage under hyperglycemic condition.
- Comprehensive Analysis of CXCR4, JUNB, and PD-L1 Expression in Circulating Tumor Cells (CTCs) from Prostate Cancer Patients.
Roumeliotou, Cells 2024 - GeneRIF: Comprehensive Analysis of CXCR4, JUNB, and PD-L1 Expression in Circulating Tumor Cells (CTCs) from Prostate Cancer Patients.
- Dual therapeutic targeting of MYC and JUNB transcriptional programs for enhanced anti-myeloma activity.
Lind, Blood cancer journal 2024 - GeneRIF: Dual therapeutic targeting of MYC and JUNB transcriptional programs for enhanced anti-myeloma activity.
- JUNB mediates oxaliplatin resistance via the MAPK signaling pathway in gastric cancer by chromatin accessibility and transcriptomic analysis.
Li, Acta biochimica et biophysica Sinica 2023 - GeneRIF: JUNB mediates oxaliplatin resistance via the MAPK signaling pathway in gastric cancer by chromatin accessibility and transcriptomic analysis.
- ZIC2 induces pro-tumor macrophage polarization in nasopharyngeal carcinoma by activating the JUNB/MCSF axis.
Liu, Cell death & disease 2023 - GeneRIF: ZIC2 induces pro-tumor macrophage polarization in nasopharyngeal carcinoma by activating the JUNB/MCSF axis.
- Transcription Factor JunB Suppresses Hepatitis C Virus Replication.
Ariffianto, The Kobe journal of medical sciences 2023 - GeneRIF: Transcription Factor JunB Suppresses Hepatitis C Virus Replication.
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- SILAC-based quantitative proteomics and microscopy analysis of cancer cells treated with the N-glycolyl GM3-specific anti-tumor antibody 14F7
Bousquet, Frontiers in immunology 2022 - “...and STAT are associated with interferon regulation and cell survival. Another transcription factor (JunB, ID: P17275) was directly down-regulated, by 1.4-fold, with 43 identified peptides (although slightly missing our criteria concerning p-value, with p=0.062. This transcription factor is involved in regulating gene activity following primary growth...”
- Docetaxel Resistance in Castration-Resistant Prostate Cancer: Transcriptomic Determinants and the Effect of Inhibiting Wnt/β-Catenin Signaling by XAV939.
Pudova, International journal of molecular sciences 2022 - “...- A6QRI9 181 UBC-201 ENSP00000344818 P0CG48 - 685 SQSTM1-202 ENSP00000374455 Q13501 - 440 JUNB-201 ENSP00000303315 P17275 Q5U079 347 CFL1-201 ENSP00000309629 P23528 V9HWI5 166 TUBB4B-201 ENSP00000341289 P68371 - 445 TUBB-205 ENSP00000339001 P07437 Q5SU16 444 S100A6-201 ENSP00000357708 P06703 - 90 TUBB3-201 ENSP00000320295 Q13509 - 450 ijms-23-12837-t007_Table 7 Table...”
- The perinuclear region concentrates disordered proteins with predicted phase separation distributed in a 3D network of cytoskeletal filaments and organelles.
do, Biochimica et biophysica acta. Molecular cell research 2022 - “...1.4 5.01 174 Q08379 GM130 92.22 0.6 1.21 175 Q14677 EpsinR 82.88 1.1 3.84 176 P17275 JunB 81.56 1.8 3.66 177 Q09472 Histone acetyltransferase p300 (p300) 77.55 6.90 1.1 4.67 178 Q92793 CREB-binding protein (CBP)/p300 76.58 25.10 (protein binding) 1.1 3.67 Zhang et al., 2021 (PMID:...”
- Proximity-Labeling Reveals Novel Host and Parasite Proteins at the Toxoplasma Parasitophorous Vacuole Membrane.
Cygan, mBio 2021 - “...USP20 0.95 Q8TEY7 Ubiquitin carboxyl-terminal hydrolase 33 USP33 0.85 P15408 Fos-related antigen 2 FOSL2 0.84 P17275 Transcription factor jun-B JUNB 0.78 P15407 Fos-related antigen 1 FOSL1 0.75 Q8WUM4 Programmed cell death 6-interacting protein PDCD6IP 0.72 Q14BN4 Sarcolemmal membrane-associated protein SLMAP 0.71 Q9UK41 Vacuolar protein sorting-associated protein...”
- A Multiplex Assay for the Stratification of Patients with Primary Central Nervous System Lymphoma Using Targeted Mass Spectrometry.
Waldera-Lupa, Cancers 2020 - “...1347 TALALEVGELVK b P46108 CRK Adapter molecule crk 0.00631 0.83 PS Medium 2253 LEDKVK a P17275 JUNB Transcription factor jun-B 0.02260 0.82 PS Medium 7149 VFINLLDSYSSGNIGK b Q96M32 AK7 Adenylate kinase 7 0.01150 0.78 PG Medium 8945 TAAQNLYEK P02655 APOC2 Apolipoprotein C-II 0.02180 0.83 PM Medium...”
- Hypocrellin A-based photodynamic action induces apoptosis in A549 cells through ROS-mediated mitochondrial signaling pathway
Qi, Acta pharmaceutica Sinica. B 2019 - “...1.28 0.06 0.022 P35354 Prostaglandin G/H synthase 2 (COX-2) 3 68.95 6.79 1.47 0.09 0.019 P17275 Transcription factor jun-B (Jun-B) 1 35.86 4.03 1.32 0.02 0.003 a P < 0.05 is considered as statistically significant when compared with control. 3.4 Mitochondrial involvement in apoptosis after HA-mediated...”
- JUNB, DUSP2, SGK1, SOCS1 and CREBBP are frequently mutated in T-cell/histiocyte-rich large B-cell lymphoma.
Schuhmacher, Haematologica 2019 - “...adopted from the Uniprot database ( www.uniprot.org ) and refer to the canonical sequences (JUNB: P17275, DUSP2: Q05923, SGK1: O00141, SOCS1: O15524, CREBBP: Q92793, FN1: P02751, TRRAP: Q9Y4A5). bZIP: basic leucine zipper motif; DsPc: dual specific phosphatase, catalytic domain; Pkinase: protein kinase domain; AGC-kinase C: AGC-kinase...”
- Integrated network pharmacology and targeted metabolomics to reveal the mechanism of nephrotoxicity of triptolide.
Huang, Toxicology research 2019 - More
XP_017208972 junB proto-oncogene, AP-1 transcription factor subunit a isoform X1 from Danio rerio
74% identity, 20% coverage
XP_010795740 transcription factor AP-1-like from Notothenia coriiceps
74% identity, 18% coverage
Q800B3 JunB protein from Takifugu rubripes
76% identity, 18% coverage
- Rainbow trout (Oncorhynchus mykiss) and ultra-low dose cancer studies.
Williams, Comparative biochemistry and physiology. Toxicology & pharmacology : CBP 2009 - “...Cell proliferation (signal transduction, transcription factors) Transmembrane 4 superfamily (AF281357) 5.44 (0.008) Transcription factor JunB (Q800B3,) 3.52 (0.005) Calmodulin (X61432) 3.11 (0.035) Estrogen receptor beta (AJ289883) 2.94 (<0.001) Protein/Ion stability and transport Cathepsin L-like cysteine peptidase (AY332270) 3.82 (0.027) Hepcidin (AF281354) 8.33 (<0.001) Extracellular matrix and...”
YP_007003813 protein ORF151D from Cyprinid herpesvirus 1
71% identity, 66% coverage
- Nach Is a Novel Subgroup at an Early Evolutionary Stage of the CNC-bZIP Subfamily Transcription Factors from the Marine Bacteria to Humans
Zhu, International journal of molecular sciences 2018 - “...Another homologous protein of Jun was also found in Cyprinid herpesvirus 1 (with accession No. YP_007003813 in GenBank), with an 87.5% BRLZ sequence consistency with human Jun ( Figure S1 b). More interestingly, additional two bZIP proteins were found in these two marine bacteria strains E...”
- “...former representative is Vb -bZIP-TF2/3 in the XBP1 clade, whilst the latter representative is Ch1 -(YP_007003813) in the Jun subgroup. More interestingly, the BATF and Jun subfamilies (including other AP-1 family members Fos and ATF2) are inferable to be originated from the putative earliest primogenitor existing...”
A0A221I039 AP-1 transcription factor subunit from Macrobrachium nipponense
69% identity, 20% coverage
NP_997915 JunB proto-oncogene, AP-1 transcription factor subunit b from Danio rerio
72% identity, 19% coverage
LOC101164062 transcription factor jun-B from Oryzias latipes
72% identity, 18% coverage
JRA_DROME / P18289 Transcription factor Jra; Jun-related antigen; Transcription factor AP-1 subunit Jra; dJRA; dJun from Drosophila melanogaster (Fruit fly) (see 4 papers)
NP_476586 Jun-related antigen, isoform A from Drosophila melanogaster
NP_724882 Jun-related antigen, isoform B from Drosophila melanogaster
66% identity, 20% coverage
- function: Transcription factor that recognizes and binds to the enhancer heptamer motif 5'-TGA[CG]TCA-3' (PubMed:1696724, PubMed:2116361). Plays a role in dorsal closure (PubMed:9224723).
subunit: Heterodimer with kay/Fra (PubMed:1696724, PubMed:2116361). The kay-Jra complex is bound more stably to the AP-1 site than either of the two proteins alone (PubMed:2116361). Interacts with Atf3; the interaction enhances the DNA-binding activity of Atf3 (PubMed:20023169).
disruption phenotype: Death in mid to late embryogenesis with large anterior and dorsal holes. - Immediate-Early Promoter-Driven Transgenic Reporter System for Neuroethological Research in a Hemimetabolous Insect
Watanabe, eNeuro 2018 - “...indicated by bars under the alignment. GenBank IDs of proteins are following: D. melanogaster Jra, NP_476586; H. sapience c-Jun, NP_002219; H. sapience Jun-B, NP_002220; H. sapience Jun-D, NP_005345. Download Figure 1-3, EPS file . 10.1523/ENEURO.0061-18.2018.f1-4 Figure 1-4 Gryllus egr gene encodes a protein closely related to...”
- Glial AP1 is activated with aging and accelerated by traumatic brain injury.
Byrns, Nature aging 2021 - GeneRIF: Glial AP1 is activated with aging and accelerated by traumatic brain injury.
- Drosophila microRNA modulates viral replication by targeting a homologue of mammalian cJun.
Monsanto-Hearne, The Journal of general virology 2017 (PubMed)- GeneRIF: Mir-8 modulates Drosophila C virus replication by negative regulation of dJun.
- Tau and spectraplakins promote synapse formation and maintenance through Jun kinase and neuronal trafficking.
Voelzmann, eLife 2016 - GeneRIF: Tau and spectraplakin promote synapse formation and maintenance through Jun kinase and neuronal trafficking.
- HP1a/KDM4A is involved in the autoregulatory loop of the oncogene gene c-Jun.
Liu, Epigenetics 2015 - GeneRIF: Jra recruits the HP1a/KDM4A complex to its gene body region upon osmotic stress to reduce H3K36 methylation levels and disrupt H3K36 methylation-dependent histone deacetylation
- Interaction between Drosophila bZIP proteins Atf3 and Jun prevents replacement of epithelial cells during metamorphosis.
Sekyrova, Development (Cambridge, England) 2010 - GeneRIF: Data thus identify Atf3 as a new functional partner of Drosophila Jun during development.
- Fos and Jun potentiate individual release sites and mobilize the reserve synaptic vesicle pool at the Drosophila larval motor synapse.
Kim, Proceedings of the National Academy of Sciences of the United States of America 2009 - GeneRIF: AP-1 mediated synapse enhancement and its relationship to increases in synapse number, Ca2+ influx, Ca2+ sensitivity of vesicle fusion or synaptic vesicle number, were examined.
- Genetic interactions between Drosophila melanogaster menin and Jun/Fos.
Cerrato, Developmental biology 2006 - GeneRIF: We observed complex genetic interactions between mnn1 and jun in different developmental settings. Our data support the idea that one function of menin is to modulate Jun activity in a manner dependent on the cellular context.
- Downregulation of lipopolysaccharide response in Drosophila by negative crosstalk between the AP1 and NF-kappaB signaling modules.
Kim, Nature immunology 2005 (PubMed)- GeneRIF: AP1 acts as a repressor by recruiting the deacetylase complex to terminate activation of a group of NF-kappaB target genes
- More
- Fly-DPI: database of protein interactomes for D. melanogaster in the approach of systems biology
Lin, BMC bioinformatics 2006 - “...indicates that the interaction has a probability score below 1. In the example case (Jra, P18289 or CG2275, with an interaction probability of 0.4, Fig. 1 ), the central node is shown as a red node. Moreover, every putative interacting edge of Jra is colored red....”
- Reciprocal regulation of glutathione S-transferase spliceforms and the Drosophila c-Jun N-terminal kinase pathway components
Udomsinprasert, The Biochemical journal 2004 - “...acids 1-104; Jun 1-104; GenBank(R) accession number P18289) were obtained by reverse transcriptase-PCR from adult Drosophila melanogaster. The PCR products were...”
NP_001037955 transcription factor jun-B from Xenopus tropicalis
70% identity, 19% coverage
NP_001090504 jun B proto-oncogene S homeolog from Xenopus laevis
68% identity, 19% coverage
LOC726289 transcription factor AP-1 from Apis mellifera
64% identity, 21% coverage
Jun / CAA73154.1 Jun from Drosophila melanogaster (see 2 papers)
62% identity, 20% coverage
LOC101736835 transcription factor JunD from Bombyx mori
62% identity, 24% coverage
- MiRNA Omics Reveal the Mechanisms of the Dual Effects of Selenium Supplementation on the Development of the Silkworm (<i>Bombyx mori</i>)
Ge, International journal of molecular sciences 2025 - “..., Ubc13 , lic , Jnk , LOC100862753 , eff , Atf-2 , Tab2 , LOC101736835 , P38mapkz , and kay . Conversely, the F_200 M group comprised the following hub genes: SmB , snf , Sf3b2 , LOC101736447 , Phf5a , LOC692813 , SmD3 ,...”
5fv8E / P05412 Structure of cjun-fosw coiled coil complex.
97% identity, 55% coverage
- Ligand: o-(o-(2-aminopropyl)-o'-(2-methoxyethyl)polypropylene glycol 500) (5fv8E)
XP_011394512 ascospore lethal-1, variant from Neurospora crassa OR74A
45% identity, 9% coverage
NP_001035403 transcription regulator protein BACH1a from Danio rerio
43% identity, 8% coverage
An02g07070 uncharacterized protein from Aspergillus niger
43% identity, 9% coverage
NP_001296999 cyclic AMP-dependent transcription factor ATF-7 isoform 2 from Mus musculus
40% identity, 14% coverage
- HNEAP Regulates Necroptosis of Cardiomyocytes by Suppressing the m5 C Methylation of Atf7 mRNA.
Wang, Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2023 - GeneRIF: HNEAP Regulates Necroptosis of Cardiomyocytes by Suppressing the m[5] C Methylation of Atf7 mRNA.
- ATF2 and ATF7 Are Critical Mediators of Intestinal Epithelial Repair.
Meijer, Cellular and molecular gastroenterology and hepatology 2020 - GeneRIF: ATF2 and ATF7 Are Critical Mediators of Intestinal Epithelial Repair.
- ATF7-Dependent Epigenetic Changes Are Required for the Intergenerational Effect of a Paternal Low-Protein Diet.
Yoshida, Molecular cell 2020 (PubMed)- GeneRIF: ATF7-Dependent Epigenetic Changes Are Required for the Intergenerational Effect of a Paternal Low-Protein Diet.
- Telomere shortening by transgenerational transmission of TNF-α-induced TERRA via ATF7.
Liu, Nucleic acids research 2019 - GeneRIF: Here, we show that TNF-alpha, which is induced by various psychological stresses, induces the p38-dependent phosphorylation of ATF7, a stress-responsive chromatin regulator, in mouse testicular germ cells. This caused a release of ATF7 from the TERRA gene promoter in the subtelomeric region, which disrupted heterochromatin and induced TERRA.
- Stress-induced and ATF7-dependent epigenetic change influences cellular senescence.
Maekawa, Genes to cells : devoted to molecular & cellular mechanisms 2019 (PubMed)- GeneRIF: ATF7 is involved in regulating lifespan and stress-induced senescence via p16Ink4a gene transcription.
- ATF7 mediates TNF-α-induced telomere shortening.
Maekawa, Nucleic acids research 2018 - GeneRIF: A decrease of ATF7 and telomerase on telomeres in response to stress causes telomere shortening, as observed in ATF7-deficient mice.
- ATF7 ablation prevents diet-induced obesity and insulin resistance.
Liu, Biochemical and biophysical research communications 2016 (PubMed)- GeneRIF: ATF7 ablation prevents diet-induced obesity and insulin resistance.
- Role of ATF7-TAF12 interactions in the vitamin D response hypersensitivity of osteoclast precursors in Paget's disease.
Teramachi, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2013 - GeneRIF: ATF7 interacts with TAF12 and contributes to the hypersensitivity of OCL precursors to 1,25-(OH)D in PD.
- More
ATF7_MOUSE / Q8R0S1 Cyclic AMP-dependent transcription factor ATF-7; cAMP-dependent transcription factor ATF-7; Activating transcription factor 7; Transcription factor ATF-A from Mus musculus (Mouse) (see 5 papers)
40% identity, 14% coverage
- function: Stress-responsive chromatin regulator that plays a role in various biological processes including innate immunological memory, adipocyte differentiation or telomerase regulation (PubMed:29490055). In absence of stress, contributes to the formation of heterochromatin and heterochromatin-like structure by recruiting histone H3K9 tri- and di-methyltransferases thus silencing the transcription of target genes such as Htr5b, STAT1 in adipocytes, or genes involved in innate immunity in macrophages and adipocytes (PubMed:19893493, PubMed:30826729, PubMed:31294895). Phosphorylation of ATF7 disrupts interactions with histone methyltransferase and enhances the association with coactivators containing histone acetyltransferase and/or histone demethylase, leading to disruption of the heterochromatin-like structure and subsequently transcriptional activation (PubMed:19893493). In response to TNF-alpha, which is induced by various stresses, phosphorylated ATF7 and telomerase are released from telomeres leading to telomere shortening (PubMed:29490055). Also plays a role in maintaining epithelial regenerative capacity and protecting against cell death during intestinal epithelial damage and repair (PubMed:31958521).
subunit: Homodimer; binds DNA as homodimer. Heterodimer; heterodimerizes with other members of ATF family and with JUN family members. Interacts with JNK2; the interaction does not phosphorylate ATF7 but acts as a docking site for other ATF-associated partners such as JUN family members. Interacts (via its transactivation domain) with TAF12 the interaction potentiates the transactivation activity and is inhibited by ATF7 sumoylation. Interacts with TAF4; the interaction inhibits the TAF12-dependent transactivation. Interacts with MAPK9; the interaction does not phosphorylate ATF7 but acts as a docking site for ATF7-associated partners such as JUN. Interacts with Ku complex components XRCC6 and XRCC7. Interacts with TERT.
disruption phenotype: Mice exhibit abnormal behaviors and increased 5- HT receptor 5B (Htr5b) mRNA levels in the dorsal raphe nuclei (PubMed:19893493). They also exhibit reduced adipose tissue mass, showing a role for ATF7 in adipocyte differentiation (PubMed:30826729). They develop severe ulceration and inflammation associated with increased epithelial apoptosis on dextran-sulfate sodium (DSS) exposure and were less able to regenerate colonic crypts on irradiation (PubMed:31294895). When combined with loss of ATF2, mice show even more epithelial damage in response to DSS (PubMed:31958521). In addition, loss of ATF7 leads to telomere shortening and chromosome instability (PubMed:29490055).
Q3US59 Predicted gene, 28047 from Mus musculus
40% identity, 14% coverage
AFUA_3G11330, Afu3g11330 bZIP transcription factor (AtfA), putative from Aspergillus fumigatus Af293
43% identity, 9% coverage
- Genome-wide patterns of noncoding and protein-coding sequence variation in the major fungal pathogen Aspergillus fumigatus
Brown, G3 (Bethesda, Md.) 2024 - “...al . 2016 ). Another gene with evidence of selection in its noncoding region is AFUA_3G11330 , which encodes the putative transcription factor AftA involved in stress response and spore viability in Aspergillus ( Lara-Rojas et al . 2011 ). The AFUA_3G11330 noncoding region exhibits a...”
- “...region present in A. fumigatus Af293 but absent in several other strains, including BA78_1337. b) AFUA_3G11330 (transcription factor AtfA) exhibits a 6-bp region absent in A. fumigatus Af293 but present in several other strains, including KXX37_005875. c) AFUA_6G03660 (predicted to be involved in the production of...”
- Distinct transcriptional responses to fludioxonil in Aspergillus fumigatus and its ΔtcsC and Δskn7 mutants reveal a crucial role for Skn7 in the cell wall reorganizations triggered by this antifungal
Schruefer, BMC genomics 2023 - “...in the wild type (log 2 FC value: -1.75 at 1h and -2.11 at 3h). Afu3g11330 encodes the transcription factor AtfA, which operates downstream of SakA [ 16 ]. This gene showed no differential expression in response to fludioxonil. In the sorbitol data set, ypd 1...”
- Aspergillus fumigatus versus Genus Aspergillus: Conservation, Adaptive Evolution and Specific Virulence Genes
Gupta, Microorganisms 2021 - “...16 h of growth. Highly downregulated PSGs at 8 h were the bZIP transcription factor Afua_3g11330 ( atfA ), followed by the ammonium transporter Afua_1g10930 ( mep2 ), while highly upregulated PSGs were 40S ribosomal protein S9-coding gene Afua_3g06970 ( rps9a ), followed by GDP-mannose pyrophosphorylase...”
- Genetic Interactions Between Aspergillus fumigatus Basic Leucine Zipper (bZIP) Transcription Factors AtfA, AtfB, AtfC, and AtfD
Silva, Frontiers in fungal biology 2021 - “...wild-type and atfA-D mutants. (A) A. fumigatus protein structure of AtfA-D family. Protein sequence AtfA (Afu3g11330), length 555 aminoacids (aa), conserved bZip domain sequence between aa 441 and 505; AtfB (Afu5g12960), length 328 aa, conserved bZip domain sequence between aa 161 and 225; AtfC (Afu1g17360), length...”
- Aspergillus fumigatus In-Host HOG Pathway Mutation for Cystic Fibrosis Lung Microenvironment Persistence
Ross, mBio 2021 - “...The HOG target genes were chosen based on their roles in response to different stresses: Afu3g11330 ( atfA ), a bZIP transcription factor required for oxidative and heat stress resistance, Afu6g09930 ( yap1 ), a key regulator of the oxidative stress response, Afu2g08250, a homolog of...”
- Phosphoproteomics of Aspergillus fumigatus Exposed to the Antifungal Drug Caspofungin
Mattos, mSphere 2020 - “...a hapB mutant (AFUA_2G14720, encoding a CAAT-binding TF) ( 30 ) and a atfA mutant (AFUA_3G11330) were more susceptible to caspofungin at 0.2g/ml than the wild-type strain and showed reduced CPE ( Fig.6 ). A pacC mutant (AFUA_3G11970, encoding a TF that undergoes activation in response...”
- “...mpkA caspo/ WT caspo sakA caspo/ WT caspo AFUA_3G11970 pacC C2H2 transcription factor PacC, putative AFUA_3G11330 atfA BZIP transcription factor (AtfA), putative AFUA_1G09670 glcD HLH transcription factor (GlcD gamma), putative AFUA_3G02340 ncb2 b CBF/NF-Y family transcription factor, putative AFUA_2G14720 hapB CCAAT-binding transcription factor subunit HAPB AFUA_2G03280...”
- Molecular Mechanisms of Conidial Germination in Aspergillus spp
Baltussen, Microbiology and molecular biology reviews : MMBR 2020 (secret) - Global gene expression reveals stress-responsive genes in Aspergillus fumigatus mycelia
Takahashi, BMC genomics 2017 - “...atfB (Afu5g12960), atfC (Afu1g17360), and atfD under the OS condition, while the expression of atfA (Afu3g11330) was 2.6-fold changed at 15min [ 28 , 35 ]. Comparing the genes observed in SS and OS, three (Afu1g01560, Afu2g03490, and Afu5g08480) and seven (Afu1g05150, Afu1g10760, Afu2g01520, Afu2g10770, azf1...”
- More
atfA AtfA from Emericella nidulans (see 2 papers)
43% identity, 10% coverage
- CharProtDB Description: Basic-region leucine zipper transcription factor; plays a role in the response of conidia to stress; Source:AspGD
AO090003000685, XP_001819834 uncharacterized protein from Aspergillus oryzae RIB40
43% identity, 10% coverage
- Molecular Mechanisms of Conidial Germination in Aspergillus spp
Baltussen, Microbiology and molecular biology reviews : MMBR 2020 (secret) - Aspergillus oryzae spore germination is enhanced by non-thermal atmospheric pressure plasma
Veerana, Scientific reports 2019 - “...(Tbf1), putative Forward-ACATCATCAGGAAGGCCAAC Reverse-GGCAATGAAAGCCTGTGTTT AO090003000611 Hydroxymethylglutaryl-CoA synthase Forward-TGCTCGTCCTCAGAACATTG Reverse-TGTCCCAGACCGATTGTGTA AO090003001496 Conserved hypothetical protein Forward-CCACTGGCCTCACTACCATT Reverse-TACAGGTTGAGGGCCAAGAC AO090003000685 ATF/CREB family transcription factor, AtfA Forward-GTCGCCAGAGGAAGAAACAG Reverse- AGAAACCGGGCAGTCCTTAT AO090206r00001 18S ribosomal RNA Forward-GGAAACTCACCAGGTCCAGA Reverse-AGCCGATAGTCCCCCTAAGA * Ten putative genes related to A . oryzae spore germination were selected for qPCR based...”
- “...highly following plasma treatment throughout the incubation period (04h; Fig. 8 ). The expression of AO090003000685 (AtfA) was significantly higher in the plasma-treated spores in both PBS and PDB at 0h, and this transcription level was maintained throughout the incubation period in PDB ( p <0.05...”
- Functional analysis of atfA gene to stress response in pathogenic thermal dimorphic fungus Penicillium marneffei
Nimmanee, PloS one 2014 - “...67.24% identical to A. fumigatus Af293 AtfA (EAL92448), 65.77% identical to A. oryzae RIB40 AtfA (XP_001819834), 65.04% identical to AtfA of A. nidulans FGSC A4 (CBF83765) and 29.83% identical to Atf1 of S . pombe 972h- (NP_595652). The conserved basic-leucine zipper (bZip) domain found in the...”
CCM_09124 bZIP transcription factor (AtfA), putative from Cordyceps militaris CM01
45% identity, 10% coverage
For advice on how to use these tools together, see
Interactive tools for functional annotation of bacterial genomes.
The PaperBLAST database links 798,070 different protein sequences to 1,261,478 scientific articles. Searches against EuropePMC were last performed on May 12 2025.
PaperBLAST builds a database of protein sequences that are linked
to scientific articles. These links come from automated text searches
against the articles in EuropePMC
and from manually-curated information from GeneRIF, UniProtKB/Swiss-Prot,
BRENDA,
CAZy (as made available by dbCAN),
BioLiP,
CharProtDB,
MetaCyc,
EcoCyc,
TCDB,
REBASE,
the Fitness Browser,
and a subset of the European Nucleotide Archive with the /experiment tag.
Given this database and a protein sequence query,
PaperBLAST uses protein-protein BLAST
to find similar sequences with E < 0.001.
To build the database, we query EuropePMC with locus tags, with RefSeq protein
identifiers, and with UniProt
accessions. We obtain the locus tags from RefSeq or from MicrobesOnline. We use
queries of the form "locus_tag AND genus_name" to try to ensure that
the paper is actually discussing that gene. Because EuropePMC indexes
most recent biomedical papers, even if they are not open access, some
of the links may be to papers that you cannot read or that our
computers cannot read. We query each of these identifiers that
appears in the open access part of EuropePMC, as well as every locus
tag that appears in the 500 most-referenced genomes, so that a gene
may appear in the PaperBLAST results even though none of the papers
that mention it are open access. We also incorporate text-mined links
from EuropePMC that link open access articles to UniProt or RefSeq
identifiers. (This yields some additional links because EuropePMC
uses different heuristics for their text mining than we do.)
For every article that mentions a locus tag, a RefSeq protein
identifier, or a UniProt accession, we try to select one or two
snippets of text that refer to the protein. If we cannot get access to
the full text, we try to select a snippet from the abstract, but
unfortunately, unique identifiers such as locus tags are rarely
provided in abstracts.
PaperBLAST also incorporates manually-curated protein functions:
- Proteins from NCBI's RefSeq are included if a
GeneRIF
entry links the gene to an article in
PubMed®.
GeneRIF also provides a short summary of the article's claim about the
protein, which is shown instead of a snippet.
- Proteins from Swiss-Prot (the curated part of UniProt)
are included if the curators
identified experimental evidence for the protein's function (evidence
code ECO:0000269). For these proteins, the fields of the Swiss-Prot entry that
describe the protein's function are shown (with bold headings).
- Proteins from BRENDA,
a curated database of enzymes, are included if they are linked to a paper in PubMed
and their full sequence is known.
- Every protein from the non-redundant subset of
BioLiP,
a database
of ligand-binding sites and catalytic residues in protein structures, is included. Since BioLiP itself
does not include descriptions of the proteins, those are taken from the
Protein Data Bank.
Descriptions from PDB rely on the original submitter of the
structure and cannot be updated by others, so they may be less reliable.
(For SitesBLAST and Sites on a Tree, we use a larger subset of BioLiP so that every
ligand is represented among a group of structures with similar sequences, but for
PaperBLAST, we use the non-redundant set provided by BioLiP.)
- Every protein from EcoCyc, a curated
database of the proteins in Escherichia coli K-12, is included, regardless
of whether they are characterized or not.
- Proteins from the MetaCyc metabolic pathway database
are included if they are linked to a paper in PubMed and their full sequence is known.
- Proteins from the Transport Classification Database (TCDB)
are included if they have known substrate(s), have reference(s),
and are not described as uncharacterized or putative.
(Some of the references are not visible on the PaperBLAST web site.)
- Every protein from CharProtDB,
a database of experimentally characterized protein annotations, is included.
- Proteins from the CAZy database of carbohydrate-active enzymes
are included if they are associated with an Enzyme Classification number.
Even though CAZy does not provide links from individual protein sequences to papers,
these should all be experimentally-characterized proteins.
- Proteins from the REBASE database
of restriction enzymes are included if they have known specificity.
- Every protein with an evidence-based reannotation (based on mutant phenotypes)
in the Fitness Browser is included.
- Sequence-specific transcription factors (including sigma factors and DNA-binding response regulators)
with experimentally-determined DNA binding sites from the
PRODORIC database of gene regulation in prokaryotes.
- Putative transcription factors from RegPrecise
that have manually-curated predictions for their binding sites. These predictions are based on
conserved putative regulatory sites across genomes that contain similar transcription factors,
so PaperBLAST clusters the TFs at 70% identity and retains just one member of each cluster.
- Coding sequence (CDS) features from the
European Nucleotide Archive (ENA)
are included if the /experiment tag is set (implying that there is experimental evidence for the annotation),
the nucleotide entry links to paper(s) in PubMed,
and the nucleotide entry is from the STD data class
(implying that these are targeted annotated sequences, not from shotgun sequencing).
Also, to filter out genes whose transcription or translation was detected, but whose function
was not studied, nucleotide entries or papers with more than 25 such proteins are excluded.
Descriptions from ENA rely on the original submitter of the
sequence and cannot be updated by others, so they may be less reliable.
Except for GeneRIF and ENA,
the curated entries include a short curated
description of the protein's function.
For entries from BioLiP, the protein's function may not be known beyond binding to the ligand.
Many of these entries also link to articles in PubMed.
For more information see the
PaperBLAST paper (mSystems 2017)
or the code.
You can download PaperBLAST's database here.
Changes to PaperBLAST since the paper was written:
- November 2023: incorporated PRODORIC and RegPrecise. Many PRODORIC entries were not linked to a protein sequence (no UniProt identifier), so we added this information.
- February 2023: BioLiP changed their download format. PaperBLAST now includes their non-redundant subset. SitesBLAST and Sites on a Tree use a larger non-redundant subset that ensures that every ligand is represented within each cluster. This should ensure that every binding site is represented.
- June 2022: incorporated some coding sequences from ENA with the /experiment tag.
- March 2022: incorporated BioLiP.
- April 2020: incorporated TCDB.
- April 2019: EuropePMC now returns table entries in their search results. This has expanded PaperBLAST's database, but most of the new entries are of low relevance, and the resulting snippets are often just lists of locus tags with annotations.
- February 2018: the alignment page reports the conservation of the hit's functional sites (if available from from Swiss-Prot or UniProt)
- January 2018: incorporated BRENDA.
- December 2017: incorporated MetaCyc, CharProtDB, CAZy, REBASE, and the reannotations from the Fitness Browser.
- September 2017: EuropePMC no longer returns some table entries in their search results. This has shrunk PaperBLAST's database, but has also reduced the number of low-relevance hits.
Many of these changes are described in Interactive tools for functional annotation of bacterial genomes.
PaperBLAST cannot provide snippets for many of the papers that are
published in non-open-access journals. This limitation applies even if
the paper is marked as "free" on the publisher's web site and is
available in PubmedCentral or EuropePMC. If a journal that you publish
in is marked as "secret," please consider publishing elsewhere.
Many important articles are missing from PaperBLAST, either because
the article's full text is not in EuropePMC (as for many older
articles), or because the paper does not mention a protein identifier such as a locus tag, or because of PaperBLAST's heuristics. If you notice an
article that characterizes a protein's function but is missing from
PaperBLAST, please notify the curators at UniProt
or add an entry to GeneRIF.
Entries in either of these databases will eventually be incorporated
into PaperBLAST. Note that to add an entry to UniProt, you will need
to find the UniProt identifier for the protein. If the protein is not
already in UniProt, you can ask them to create an entry. To add an
entry to GeneRIF, you will need an NCBI Gene identifier, but
unfortunately many prokaryotic proteins in RefSeq do not have
corresponding Gene identifers.
References
PaperBLAST: Text-mining papers for information about homologs.
M. N. Price and A. P. Arkin (2017). mSystems, 10.1128/mSystems.00039-17.
Europe PMC in 2017.
M. Levchenko et al (2017). Nucleic Acids Research, 10.1093/nar/gkx1005.
Gene indexing: characterization and analysis of NLM's GeneRIFs.
J. A. Mitchell et al (2003). AMIA Annu Symp Proc 2003:460-464.
UniProt: the universal protein knowledgebase.
The UniProt Consortium (2016). Nucleic Acids Research, 10.1093/nar/gkw1099.
BRENDA in 2017: new perspectives and new tools in BRENDA.
S. Placzek et al (2017). Nucleic Acids Research, 10.1093/nar/gkw952.
The EcoCyc database: reflecting new knowledge about Escherichia coli K-12.
I. M. Keeseler et al (2016). Nucleic Acids Research, 10.1093/nar/gkw1003.
The MetaCyc database of metabolic pathways and enzymes.
R. Caspi et al (2018). Nucleic Acids Research, 10.1093/nar/gkx935.
CharProtDB: a database of experimentally characterized protein annotations.
R. Madupu et al (2012). Nucleic Acids Research, 10.1093/nar/gkr1133.
The carbohydrate-active enzymes database (CAZy) in 2013.
V. Lombard et al (2014). Nucleic Acids Research, 10.1093/nar/gkt1178.
The Transporter Classification Database (TCDB): recent advances
M. H. Saier, Jr. et al (2016). Nucleic Acids Research, 10.1093/nar/gkv1103.
REBASE - a database for DNA restriction and modification: enzymes, genes and genomes.
R. J. Roberts et al (2015). Nucleic Acids Research, 10.1093/nar/gku1046.
Deep annotation of protein function across diverse bacteria from mutant phenotypes.
M. N. Price et al (2016). bioRxiv, 10.1101/072470.
by Morgan Price,
Arkin group
Lawrence Berkeley National Laboratory