PaperBLAST
PaperBLAST Hits for 89 a.a. (SAITLWQFLL...)
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>89 a.a. (SAITLWQFLL...)
SAITLWQFLLQLLQKPQNKHMICWTSNDGQFKLLQAEEVARLWGIRKNKPNMNYDKLSRA
LRYYYVKNIIKKVNGQKFVYKFVSYPEIL
Running BLASTp...
Found 185 similar proteins in the literature:
ELK4_HUMAN / P28324 ETS domain-containing protein Elk-4; Serum response factor accessory protein 1; SAP-1; SRF accessory protein 1 from Homo sapiens (Human) (see paper)
NP_001964 ETS domain-containing protein Elk-4 isoform a from Homo sapiens
100% identity, 21% coverage
- function: Involved in both transcriptional activation and repression. Interaction with SIRT7 leads to recruitment and stabilization of SIRT7 at promoters, followed by deacetylation of histone H3 at 'Lys-18' (H3K18Ac) and subsequent transcription repression. Forms a ternary complex with the serum response factor (SRF). Requires DNA-bound SRF for ternary complex formation and makes extensive DNA contacts to the 5'side of SRF, but does not bind DNA autonomously.
subunit: Interacts with SIRT7. - The HLA Ligandome Comprises a Limited Repertoire of O-GlcNAcylated Antigens Preferentially Associated With HLA-B*07:02.
Mukherjee, Frontiers in immunology 2021 - “...E3 Ubiquitin-protein ligase synoviolin Endoplasmic reticulum HLA-B*07:02 742 405414 ( 26 ) 13 APTSASNVM 9 P28324 ETS domain-containing protein Elk-4 Nucleus HLA-B*07:02 22 238-246 CS 14 VLTSNVQTI 9 P32519 ETS-related transcription factor Elf-1 Nucleus HLA-A*02:01 376 507-515 CS 15 RPPSSSQQL 9 Q8WYB5 Histone acetyltransferase KAT6B Nucleus...”
- Deep sequencing reveals novel Set7 networks.
Keating, Cellular and molecular life sciences : CMLS 2014 - ELK4 targets CHMP6 to inhibit ferroptosis and enhance malignant properties of skin cutaneous melanoma cells.
Li, Archives of dermatological research 2024 (PubMed)- GeneRIF: ELK4 targets CHMP6 to inhibit ferroptosis and enhance malignant properties of skin cutaneous melanoma cells.
- ELK4 Promotes Cell Cycle Progression and Stem Cell-like Characteristics in HPV-associated Cervical Cancer by Regulating the FBXO22/PTEN Axis
Gao, Balkan medical journal 2023 - GeneRIF: ELK4 Promotes Cell Cycle Progression and Stem Cell-like Characteristics in HPV-associated Cervical Cancer by Regulating the FBXO22/PTEN Axis.
- IGF1R-phosphorylated PYCR1 facilitates ELK4 transcriptional activity and sustains tumor growth under hypoxia.
Zheng, Nature communications 2023 - GeneRIF: IGF1R-phosphorylated PYCR1 facilitates ELK4 transcriptional activity and sustains tumor growth under hypoxia.
- ELK4 promotes the development of gastric cancer by inducing M2 polarization of macrophages through regulation of the KDM5A-PJA2-KSR1 axis.
Zheng, Journal of translational medicine 2021 - GeneRIF: ELK4 promotes the development of gastric cancer by inducing M2 polarization of macrophages through regulation of the KDM5A-PJA2-KSR1 axis.
- ELK4-mediated lncRNA SNHG22 promotes gastric cancer progression through interacting with EZH2 and regulating miR-200c-3p/Notch1 axis.
Mao, Cell death & disease 2021 - GeneRIF: ELK4-mediated lncRNA SNHG22 promotes gastric cancer progression through interacting with EZH2 and regulating miR-200c-3p/Notch1 axis.
- TRA2A-induced upregulation of LINC00662 regulates blood-brain barrier permeability by affecting ELK4 mRNA stability in Alzheimer's microenvironment.
Liu, RNA biology 2020 - GeneRIF: TRA2A-induced upregulation of LINC00662 regulates blood-brain barrier permeability by affecting ELK4 mRNA stability in Alzheimer's microenvironment.
- Ubiquitin-specific peptidase 7 (USP7)-mediated deubiquitination of the histone deacetylase SIRT7 regulates gluconeogenesis.
Jiang, The Journal of biological chemistry 2017 - GeneRIF: Data suggest that SIRT7 undergoes Lys-63 polyubiquitination, later removed by USP7 to repress enzymatic activity of SIRT7; USP7 and SIRT7 regulate gluconeogenesis via expression of glucose-6-phosphatase catalytic subunit (G6PC); SIRT7 targets G6PC promoter through ELK4. (SIRT7 = sirtuin 7; USP7 = ubiquitin specific peptidase 7; G6PC = glucose-6-phosphatase catalytic subunit; ELK4 = transcription factor ELK4)
- Cyclin-dependent kinase 2 (CDK2) is a key mediator for EGF-induced cell transformation mediated through the ELK4/c-Fos signaling pathway.
Peng, Oncogene 2016 - GeneRIF: ELK4 is overexpressed in melanoma and knocking down the ELK4 or CDK2 expression significantly attenuated the malignant phenotype of melanoma cells
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1hbxG / P28324 Ternary complex of sap-1 and srf with specific sre DNA (see paper)
100% identity, 79% coverage
NP_031949 ETS domain-containing protein Elk-4 isoform 1 from Mus musculus
96% identity, 21% coverage
- ELK4 ameliorates cognitive impairment and neuroinflammation induced by obstructive sleep apnea.
Yang, Brain research bulletin 2024 (PubMed)- GeneRIF: ELK4 ameliorates cognitive impairment and neuroinflammation induced by obstructive sleep apnea.
- CircELK4 Contributes to Lupus Nephritis by Acting as a miR-27b-3p Sponge to Regulate STING/IRF3/IFN-I Signaling.
Xu, Inflammation 2021 (PubMed)- GeneRIF: CircELK4 Contributes to Lupus Nephritis by Acting as a miR-27b-3p Sponge to Regulate STING/IRF3/IFN-I Signaling.
- ERK Signaling Controls Innate-like CD8+ T Cell Differentiation via the ELK4 (SAP-1) and ELK1 Transcription Factors.
Maurice, Journal of immunology (Baltimore, Md. : 1950) 2018 - GeneRIF: These data establish that low-level ERK signaling through ELK4 (and ELK1) promotes innate-like alphabeta CD8(+) T cell differentiation, tuning conventional versus innate-like development.
- Binding and inhibition of the ternary complex factor Elk-4/Sap1 by the adapter protein Dok-4.
Hooker, The Biochemical journal 2017 (PubMed)- GeneRIF: Dok-4 can target Elk-4 activity through multiple mechanisms, including binding of the transactivation domain, nuclear exclusion and protein destabilization.
- MKL1/2 and ELK4 co-regulate distinct serum response factor (SRF) transcription programs in macrophages.
Xie, BMC genomics 2014 - GeneRIF: MKL1/2 and ELK4 co-regulate distinct serum response factor (SRF) transcription programs in macrophages.
- Ternary complex factors SAP-1 and Elk-1, but not net, are functionally equivalent in thymocyte development.
Costello, Journal of immunology (Baltimore, Md. : 1950) 2010 (PubMed)- GeneRIF: Data show that Elk-1 and Net do not contribute significantly to thymocyte development in the presence of SAP-1.
- Raf signaling but not the ERK effector SAP-1 is required for regulatory T cell development.
Willoughby, Journal of immunology (Baltimore, Md. : 1950) 2007 - GeneRIF: T cell positive selection, and ERK signaling to SAP-1 is not required for the suppressive activity of T(reg) cells.
- Ternary complex factor SAP-1 is required for Erk-mediated thymocyte positive selection.
Costello, Nature immunology 2004 (PubMed)- GeneRIF: SAP-1 is required for Erk-mediated transcriptional events in thymocyte development.
XP_018087290 ELK1, member of ETS oncogene family S homeolog isoform X2 from Xenopus laevis
80% identity, 21% coverage
P41971 ETS domain-containing protein Elk-3 from Mus musculus
81% identity, 22% coverage
- Genome-Scale Phylogeny and Evolutionary Analysis of Ross River Virus Reveals Periodic Sweeps of Lineage Dominance in Western Australia, 1977-2014.
Michie, Journal of virology 2020 - “...G2: SW12358, K3011, WK20, AN572.2 G3: AN572.1, AN205, SW2089, P42134, P41472, P41453, P42161, P42273, P42115, P41971 G4: P5131, QML1, SW99359, SE1168, DC59627, SW94735, MIDI13, SW94735, SW97414, DC55607, RRV_TT, K79390, K78118, K76352, K80776, K80535, K67847, K65195, K61297, DC36486, SW72780, SW72209, SW64247, DC29695 441 0.085 0.158 0.042 0.982...”
- Pulmonary Proteome and Protein Networks in Response to the Herbicide Paraquat in Rats.
Cho, Journal of proteomics & bioinformatics 2015 - “...) 13 249 (33) Q80W87 Angiogenesis ETS domain-containing protein ( ELK3 ) 14 145 (33) P41971 Angiogenesis Collagen alpha-2 (IV) chain ( COL4A2 ) 12 140 (30) P08122 Angiogenesis Nitric oxide synthase 3 ( NOS3 ) 12 140 (30) P70313 Lung development/Cardiovascular-cancer-respiratory pathway Neurotransmitters Glutamate receptor,...”
NP_031948 ETS domain-containing protein Elk-1 from Mus musculus
77% identity, 20% coverage
- Vascular injury activates the ELK1/SND1/SRF pathway to promote vascular smooth muscle cell proliferative phenotype and neointimal hyperplasia.
Su, Cellular and molecular life sciences : CMLS 2024 - GeneRIF: Vascular injury activates the ELK1/SND1/SRF pathway to promote vascular smooth muscle cell proliferative phenotype and neointimal hyperplasia.
- ANXA3 interference inactivates ERK/ELK1 pathway to mitigate inflammation and apoptosis in sepsis-associated acute lung injury.
Liang, Molecular immunology 2024 (PubMed)- GeneRIF: ANXA3 interference inactivates ERK/ELK1 pathway to mitigate inflammation and apoptosis in sepsis-associated acute lung injury.
- BMAL1 inhibits renal fibrosis and renal interstitial inflammation by targeting the ERK1/2/ELK-1/Egr-1 axis.
Chen, International immunopharmacology 2023 (PubMed)- GeneRIF: BMAL1 inhibits renal fibrosis and renal interstitial inflammation by targeting the ERK1/2/ELK-1/Egr-1 axis.
- The Elk1/MMP-9 axis regulates E-cadherin and occludin in ventilator-induced lung injury.
Tao, Respiratory research 2021 - GeneRIF: The Elk1/MMP-9 axis regulates E-cadherin and occludin in ventilator-induced lung injury.
- Critical Protein-Protein Interactions Determine the Biological Activity of Elk-1, a Master Regulator of Stimulus-Induced Gene Transcription.
Thiel, Molecules (Basel, Switzerland) 2021 - GeneRIF: Critical Protein-Protein Interactions Determine the Biological Activity of Elk-1, a Master Regulator of Stimulus-Induced Gene Transcription.
- MicroRNA-150 and its target ETS-domain transcription factor 1 contribute to inflammation in diabetic photoreceptors.
Yu, Journal of cellular and molecular medicine 2021 - GeneRIF: MicroRNA-150 and its target ETS-domain transcription factor 1 contribute to inflammation in diabetic photoreceptors.
- Loss of ELK1 has differential effects on age-dependent organ fibrosis.
Cairns, The international journal of biochemistry & cell biology 2020 - GeneRIF: Loss of ELK1 has differential effects on age-dependent organ fibrosis.
- Elk-1 transcriptionally regulates ZC3H4 expression to promote silica-induced epithelial-mesenchymal transition.
Jiang, Laboratory investigation; a journal of technical methods and pathology 2020 (PubMed)- GeneRIF: Elk-1 transcriptionally regulates ZC3H4 expression to promote silica-induced epithelial-mesenchymal transition.
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ELK1_RAT / A4GTP4 ETS domain-containing protein Elk-1 from Rattus norvegicus (Rat) (see paper)
XP_006256676 ETS domain-containing protein Elk-1 isoform X1 from Rattus norvegicus
77% identity, 20% coverage
- function: Transcription factor that binds to purine-rich DNA sequences. Forms a ternary complex with SRF and the ETS and SRF motifs of the serum response element (SRE) on the promoter region of immediate early genes such as FOS and IER2 (By similarity) (PubMed:17156131). Induces target gene transcription upon JNK and MAPK-signaling pathways stimulation (PubMed:17156131).
subunit: Interacts in its sumoylated form with PIAS2/PIASX which enhances its transcriptional activator activity. Interacts with MAD2L2; the interaction is direct and promotes phosphorylation by the kinases MAPK8 and/or MAPK9. Interacts with POU1F1. - Elk1 enhances inflammatory cell infiltration and exacerbates acute lung injury/acute respiratory distress syndrome by suppressing Fcgr2b transcription.
Wei, Molecular medicine (Cambridge, Mass.) 2024 - GeneRIF: Elk1 enhances inflammatory cell infiltration and exacerbates acute lung injury/acute respiratory distress syndrome by suppressing Fcgr2b transcription.
- ETS-domain containing protein (Elk1) suppression protects cortical neurons against oxygen-glucose deprivation injury.
Lu, Experimental cell research 2018 (PubMed)- GeneRIF: Elk1 suppression protects cortical neurons against oxygen-glucose deprivation injury.
- Insulin-activated Elk-1 recruits the TIP60/NuA4 complex to increase prolactin gene transcription.
Mahajan, Molecular and cellular endocrinology 2014 (PubMed)- GeneRIF: insulin activates prolactin gene transcription by activating Elk-1 that recruits the NuA4 complex to the promoter.
- Centaurin-α1-Ras-Elk-1 signaling at mitochondria mediates β-amyloid-induced synaptic dysfunction.
Szatmari, The Journal of neuroscience : the official journal of the Society for Neuroscience 2013 - GeneRIF: The CentA1-Ras-Elk-1 signaling pathway acts on mitochondria to regulate dendritic spine density and synaptic plasticity in response to Abeta in hippocampal neurons.
- Morphine activates the E twenty six-like transcription factor-1/serum response factor pathway via extracellular signal-regulated kinases 1/2 in F11 cells derived from dorsal root ganglia neurons.
Rothe, The Journal of pharmacology and experimental therapeutics 2012 (PubMed)- GeneRIF: Morphine activates ELK-1 via ERK-1/2 in DRG-derived F11 cells endogenously expressing mu and delta ORs.
- ETS-domain transcription factor Elk-1 mediates neuronal survival: SMN as a potential target.
Demir, Biochimica et biophysica acta 2011 (PubMed)- GeneRIF: RNAi-mediated depletion of endogenous Elk-1 results in increased caspase activity
- Estrogen receptor beta stimulates Egr-1 transcription via MEK1/Erk/Elk-1 cascade in C6 glioma cells.
Kim, BMB reports 2011 (PubMed)- GeneRIF: ERbeta promoted up-regulation of Egr-1 expression via a non-genomic mechanism involving the Raf/MEK1/Erk/Elk-1 signaling cascade.
- Elk-1 interacts with neuronal microtubules and relocalizes to the nucleus upon phosphorylation.
Demir, Molecular and cellular neurosciences 2009 (PubMed)- GeneRIF: Results suggest that Elk-1 is anchored to neuronal microtubules in resting or unstimulated cells, and upon stimulation is phosphorylated, which relocalizes phospho-Elk-1 to the nucleus in neurons.
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ELK1_HUMAN / P19419 ETS domain-containing protein Elk-1 from Homo sapiens (Human) (see 9 papers)
NP_005220 ETS domain-containing protein Elk-1 isoform a from Homo sapiens
77% identity, 20% coverage
- function: Transcription factor that binds to purine-rich DNA sequences (PubMed:10799319, PubMed:7889942). Forms a ternary complex with SRF and the ETS and SRF motifs of the serum response element (SRE) on the promoter region of immediate early genes such as FOS and IER2 (PubMed:1630903). Induces target gene transcription upon JNK and MAPK- signaling pathways stimulation (PubMed:7889942).
subunit: Interacts in its sumoylated form with PIAS2/PIASX which enhances its transcriptional activator activity (PubMed:15920481). Interacts with MAD2L2; the interaction is direct and promotes phosphorylation by the kinases MAPK8 and/or MAPK9 (PubMed:17296730). Interacts with POU1F1 (PubMed:26612202). - A-Kinase Anchor Protein 95 Is Involved in ERK1/2-Elk-1 Signal Transduction in Colon Cancer.
Kong, Analytical cellular pathology (Amsterdam) 2023 - GeneRIF: A-Kinase Anchor Protein 95 Is Involved in ERK1/2-Elk-1 Signal Transduction in Colon Cancer.
- Role of ELK1 in regulating colorectal cancer progression: miR-31-5p/CDIP1 axis in CRC pathogenesis.
Yan, PeerJ 2023 - GeneRIF: Role of ELK1 in regulating colorectal cancer progression: miR-31-5p/CDIP1 axis in CRC pathogenesis.
- Knockdown of lncRNA LINC00662 suppresses malignant behaviour of osteosarcoma cells via competition with miR-30b-3p to regulate ELK1 expression.
Wang, Journal of orthopaedic surgery and research 2022 - GeneRIF: Knockdown of lncRNA LINC00662 suppresses malignant behaviour of osteosarcoma cells via competition with miR-30b-3p to regulate ELK1 expression.
- Sirt7 associates with ELK1 to participate in hyperglycemia memory and diabetic nephropathy via modulation of DAPK3 expression and endothelial inflammation.
Li, Translational research : the journal of laboratory and clinical medicine 2022 (PubMed)- GeneRIF: Sirt7 associates with ELK1 to participate in hyperglycemia memory and diabetic nephropathy via modulation of DAPK3 expression and endothelial inflammation.
- ELK1 suppresses SYTL1 expression by recruiting HDAC2 in bladder cancer progression.
Wang, Human cell 2022 (PubMed)- GeneRIF: ELK1 suppresses SYTL1 expression by recruiting HDAC2 in bladder cancer progression.
- The autism risk factor CHD8 is a chromatin activator in human neurons and functionally dependent on the ERK-MAPK pathway effector ELK1.
Haddad, Scientific reports 2022 - GeneRIF: The autism risk factor CHD8 is a chromatin activator in human neurons and functionally dependent on the ERK-MAPK pathway effector ELK1.
- ELK1 activated-long noncoding RNA LBX2-AS1 aggravates the progression of ovarian cancer through targeting miR-4784/KDM5C axis.
Gu, Journal of molecular histology 2021 (PubMed)- GeneRIF: ELK1 activated-long noncoding RNA LBX2-AS1 aggravates the progression of ovarian cancer through targeting miR-4784/KDM5C axis.
- c-KIT-ERK1/2 signaling activated ELK1 and upregulated carcinoembryonic antigen expression to promote colorectal cancer progression.
Ma, Cancer science 2021 - GeneRIF: c-KIT-ERK1/2 signaling activated ELK1 and upregulated carcinoembryonic antigen expression to promote colorectal cancer progression.
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- Insulin signaling and pharmacology in humans and in corals
Murthy, PeerJ 2024 - “...translation initiation factor 4E P06730 (IF4E_HUMAN) Yanagiya et al. (2012) Elk1 ETS domain-containing protein Elk-1 P19419 (ELK1_HUMAN) Gille et al. (1995) FAS Tumor necrosis factor receptor superfamily member 6 P25445 (TNR6_HUMAN) Cascino et al. (1995) FBP Fructose-1,6-bisphosphatase 1 Fructose-1,6-bisphosphatase isozyme 2 P09467 (F16P1_HUMAN) O00757 (F16P2_HUMAN) El-Maghrabi...”
- “...translation initiation factor 4E 217 pdam_00019745 100 1.10E43 2.50E47 186 32217 37232 (232) 63 Elk1 P19419 ETS domain-containing protein Elk-1 428 pdam_00014011 100 6.60E39 1.30E42 163 4177 14181 (204) 41 FAS P25445 Tumor necrosis factor receptor superfamily member 6 335 pdam_00022994 99.9 4.20E28 8.90E32 242 60317...”
- Exploration of the effect and mechanism of Scutellaria barbata D. Don in the treatment of ovarian cancer based on network pharmacology and in vitro experimental verification
Zhang, Medicine 2023 - “...factor P01133 94 CDKN2A Cyclin-dependent kinase inhibitor 2A P42771 95 ELK1 ETS domain-containing protein Elk-1 P19419 96 ODC1 Ornithine decarboxylase P11926 97 RAF1 RAF proto-oncogene serine/threonine-protein kinase P04049 98 SOD1 Superoxide dismutase P00441 99 STAT1 Signal transducer and activator of transcription 1-alpha/beta P42224 100 HSPA5 Endoplasmic...”
- TGF-β phospho antibody array identifies altered SMAD2, PI3K/AKT/SMAD, and RAC signaling contribute to the pathogenesis of myxomatous mitral valve disease.
McNair, Frontiers in veterinary science 2023 - “...16 BRAF H P15056 60 c-RAF HMR P04049 61 CREB HMR P16220 1 Elk1 H,M,R P19419 20 ERK1 H P27361 33 ERK2 H P28482 22 ERK3 H P16659 21 ERK4 H P31152 9 ERK7 H Q8TD08 10 GSK3 alpha H P49840 15 GSK3 beta H,M,R P49841...”
- Investigation of the anti-tumor mechanism of tirabrutinib, a highly selective Bruton's tyrosine kinase inhibitor, by phosphoproteomics and transcriptomics.
Kozaki, PloS one 2023 - “...of the erythroblast transformation-specific (ETS) domain-containing protein Elk-1 (corresponds to Ser-422 in the UniProtKB entry P19419), a member of the ETS family. This residue is known to be phosphorylated by ERK1 and involves ternary complex formation, which is a prerequisite for manifesting transactivation potential [ 46...”
- Repurposing of a human antibody-based microarray to explore conserved components of the signalome of the parasitic nematode Haemonchus contortus
Adderley, Parasites & vectors 2022 - “...a Stage p70 S6K T252 TL(pS)PI P23443 31.62 HCON_00079680 0.71201 Yes Adult ELK1 S383 MA(pS)GVA P19419 2.61 HCON_00127560 0.3449 No Adult eIF4E S209 KSG(pS)TTK P06730 2.38 HCON_00133690 0.81774 Yes Adult Integrin a4 S1021 RRD(pS)WSY P13612 2.23 HCON_00080620 0.50131 Yes Adult Histone H3 S28 ARK(pS)APS P84243 2.21...”
- Ribosomal protein L5 facilitates rDNA-bundled condensate and nucleolar assembly.
Matsumori, Life science alliance 2022 - “...lipid metabolism Cell membrane O14939 ELK1 ETS domain-containing protein Elk-1 Activator, transcription, transcription regulation Nucleus P19419 TRIM28 Transcription intermediary factor 1-beta Ligase, repressor, transcription regulation, Ubl conjugation pathway Nucleus Q13263 WBP11 WW domain-binding protein 11 mRNA processing, mRNA splicing, rRNA processing Cytoplasm, nucleus Q9Y2W2 To quantitatively...”
- Enhanced Anti-Cancer Effects of Conditioned Medium from Hypoxic Human Adult Dermal Fibroblasts on Cervical Cancer Cells.
Han, International journal of molecular sciences 2022 - “...Q70CQ3 ADH7 1 2.264 () P40394 DNM1 1 2.071 (-) Q05193 ELK1 1 2.165 (-) P19419 GAD1 1 2.075 (+) Q99259 GPRIN2 1 3.252 (+) O60269 GPR18 1 2.408 () Q14330 GRTP1 1 3.786 (+) Q5TC63 IAPP 1 2.501 () P10997 IP6K2 1 2.393 () Q9UHH9...”
- Network pharmacology based research into the effect and mechanism of Yinchenhao Decoction against Cholangiocarcinoma
Chen, Chinese medicine 2021 - “...P05412 45 TP53 P04637 69 ALOX5 P09917 93 MAPK8 P45983 22 CASP3 P42574 46 ELK1 P19419 70 PTEN P60484 94 SLPI P03973 23 CASP8 Q14790 47 RAF1 P04049 71 MPO P05164 95 ADH1C P00326 24 PRKCA P17252 48 MMP1 P03956 72 ABCG2 Q9UNQ0 96 MAOA P21397...”
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1duxC / P19419 Elk-1/DNA structure reveals how residues distal from DNA-binding surface affect DNA-recognition (see paper)
79% identity, 96% coverage
NP_005221 ETS domain-containing protein Elk-3 isoform 1 from Homo sapiens
P41970 ETS domain-containing protein Elk-3 from Homo sapiens
83% identity, 22% coverage
- ELK3 destabilization by speckle-type POZ protein suppresses prostate cancer progression and docetaxel resistance.
Lee, Cell death & disease 2024 - GeneRIF: ELK3 destabilization by speckle-type POZ protein suppresses prostate cancer progression and docetaxel resistance.
- ELK3-CXCL16 axis determines natural killer cell cytotoxicity via the chemotactic activity of CXCL16 in triple negative breast cancer.
Jung, Oncoimmunology 2023 - GeneRIF: ELK3-CXCL16 axis determines natural killer cell cytotoxicity via the chemotactic activity of CXCL16 in triple negative breast cancer.
- ELK3 Targeting AEG1 Promotes Migration and Invasion of Ovarian Cancer Cells under Hypoxia.
Yu, Biological & pharmaceutical bulletin 2023 (PubMed)- GeneRIF: ELK3 Targeting AEG1 Promotes Migration and Invasion of Ovarian Cancer Cells under Hypoxia.
- ETS transcription factor ELK3 in human cancers: An emerging therapeutic target.
Al-Hawary, Pathology, research and practice 2023 (PubMed)- GeneRIF: ETS transcription factor ELK3 in human cancers: An emerging therapeutic target.
- ELK3-ID4 axis governs the metastatic features of triple negative breast cancer.
Choi, Oncology research 2023 - GeneRIF: ELK3-ID4 axis governs the metastatic features of triple negative breast cancer.
- ELK3 Controls Gastric Cancer Cell Migration and Invasion by Regulating ECM Remodeling-Related Genes.
Lee, International journal of molecular sciences 2022 - GeneRIF: ELK3 Controls Gastric Cancer Cell Migration and Invasion by Regulating ECM Remodeling-Related Genes.
- Molecular and clinical features of a potential immunotherapy target ELK3 in glioma.
Xu, Medicine 2022 - GeneRIF: Molecular and clinical features of a potential immunotherapy target ELK3 in glioma.
- Circular RNA hsa_circ_0000144 aggravates ovarian Cancer progression by regulating ELK3 via sponging miR-610.
Wu, Journal of ovarian research 2022 - GeneRIF: Circular RNA hsa_circ_0000144 aggravates ovarian Cancer progression by regulating ELK3 via sponging miR-610.
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- Active DHEA uptake in the prostate gland correlates with aggressive prostate cancer.
Zhang, The Journal of clinical investigation 2023 - “...the manufacturers instructions. Firstly, purified 3HSD1 protein solution was added into 1 PBS Buffer (Abcone, P41970) containing 0.1% BSA (Thermo Fisher Scientific, 37525) and 10 M inhibitors from the small-molecule library. The reaction was incubated for 30 minutes at 4C. Secondly, 1 mM NAD + and...”
- “...HPLC technology in vitro. Purified 3HSD1 protein solution was added into 1 PBS Buffer (Abcone, P41970) containing 200 M NAD + , 1 M inhibitors, [ 3 H]-labeled DHEA, and 0.1% BSA. Reactions were allowed to proceed at 37C for 30 minutes. Statistics. Unpaired 1-tailed and...”
- Sequence and structural analyses of nuclear export signals in the NESdb database
Xu, Molecular biology of the cell 2012 - “...F VK V LEK V D V 185 + 2CT9 EEHHHHHHCCCCCCH 0.34 0.25 Net 98 P41970 1 MES A IT L WQF L LQ L 14 + 1HBX CCCCHHHHCCCCC 0.32 0.23 Hxk2 120 P04807 19 VPKE L MQQ I EN F EK I 33 1IG8 CCHHHHHHHHHHHHH...”
NP_001025920 ETS domain-containing protein Elk-3 from Gallus gallus
83% identity, 22% coverage
ETV4_MOUSE / P28322 ETS translocation variant 4; Polyomavirus enhancer activator 3; Protein PEA3 from Mus musculus (Mouse) (see paper)
62% identity, 18% coverage
- function: Transcriptional activator (PubMed:1547944). May play a role in keratinocyte differentiation (By similarity).
XP_006532523 ETS translocation variant 4 isoform X3 from Mus musculus
62% identity, 17% coverage
- ETV4 mediates dosage-dependent prostate tumor initiation and cooperates with p53 loss to generate prostate cancer.
Li, Science advances 2023 - GeneRIF: ETV4 mediates dosage-dependent prostate tumor initiation and cooperates with p53 loss to generate prostate cancer.
- Etv4 regulates nociception by controlling peptidergic sensory neuron development and peripheral tissue innervation.
Ríos, Development (Cambridge, England) 2022 (PubMed)- GeneRIF: Etv4 regulates nociception by controlling peptidergic sensory neuron development and peripheral tissue innervation.
- Transcription factor gene Pea3 regulates erectile function during copulation in mice.
Weinrich, PloS one 2022 - GeneRIF: Transcription factor gene Pea3 regulates erectile function during copulation in mice.
- Amniotic fluid mesenchymal stem cells repair mouse corneal cold injury by promoting mRNA N4-acetylcytidine modification and ETV4/JUN/CCND2 signal axis activation.
Fei, Human cell 2021 - GeneRIF: Amniotic fluid mesenchymal stem cells repair mouse corneal cold injury by promoting mRNA N4-acetylcytidine modification and ETV4/JUN/CCND2 signal axis activation.
- Etv transcription factors functionally diverge from their upstream FGF signaling in lens development.
Garg, eLife 2020 - GeneRIF: Etv transcription factors functionally diverge from their upstream FGF signaling in lens development.
- Pea3 Transcription Factors, Etv4 and Etv5, Are Required for Proper Hippocampal Dendrite Development and Plasticity.
Fontanet, Cerebral cortex (New York, N.Y. : 1991) 2018 (PubMed)- GeneRIF: This study demonstrates that Etv4 and Etv5 transcription factors are expressed in hippocampal pyramidal neurons during the main period of dendritogenesis; reveals a novel role for Etv4 and Etv5 transcription factors for hippocampal circuit development and the coordination of synaptic maturation; and indicates that both factors are essential in the transcriptional program linking BDNF signaling to dendrite development.
- Phosphorylation of ETV4 at Ser73 by ERK kinase could block ETV4 ubiquitination degradation in colorectal cancer.
Xiao, Biochemical and biophysical research communications 2017 (PubMed)- GeneRIF: Our results will help understand the mechanism of ETV4 overexpression in CRC patients and provide a clue to search new therapeutic target to treat the related tumors in clinical practice.
- Fibroblast growth factors (FGFs) prime the limb specific Shh enhancer for chromatin changes that balance histone acetylation mediated by E26 transformation-specific (ETS) factors.
Peluso, eLife 2017 - GeneRIF: The E26 transformation-specific transcription factor, ETV4, which is induced by fibroblast growth factor signalling and acts as a repressor of ZRS activity, interacts with the histone deacetylase HDAC2 and ensures that the poised ZRS remains transcriptionally inactive.
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NP_001248366 ETS translocation variant 4 isoform 2 from Homo sapiens
62% identity, 20% coverage
- The Mediating Role of miR-451/ETV4/MMP13 Signaling Axis on Epithelialmesenchymal Transition in Promoting Non-small Cell Lung Cancer Progression.
Qian, Current molecular pharmacology 2024 (PubMed)- GeneRIF: The Mediating Role of miR-451/ETV4/MMP13 Signaling Axis on Epithelialmesenchymal Transition in Promoting Non-small Cell Lung Cancer Progression.
- ETV4-Dependent Transcriptional Plasticity Maintains MYC Expression and Results in IMiD Resistance in Multiple Myeloma.
Neri, Blood cancer discovery 2024 - GeneRIF: ETV4-Dependent Transcriptional Plasticity Maintains MYC Expression and Results in IMiD Resistance in Multiple Myeloma.
- ETV4 is a mechanical transducer linking cell crowding dynamics to lineage specification.
Yang, Nature cell biology 2024 - GeneRIF: ETV4 is a mechanical transducer linking cell crowding dynamics to lineage specification.
- Transcription Factor ETV4 Activates AURKA to Promote PD-L1 Expression and Mediate Immune Escape in Lung Adenocarcinoma.
Yang, International archives of allergy and immunology 2024 (PubMed)- GeneRIF: Transcription Factor ETV4 Activates AURKA to Promote PD-L1 Expression and Mediate Immune Escape in Lung Adenocarcinoma.
- An oncogenic enhancer promotes melanoma progression via regulating ETV4 expression.
Zhang, Journal of translational medicine 2024 - GeneRIF: An oncogenic enhancer promotes melanoma progression via regulating ETV4 expression.
- ETV4 Mediated Tumor-Associated Neutrophil Infiltration Facilitates Lymphangiogenesis and Lymphatic Metastasis of Bladder Cancer.
Zhang, Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2023 - GeneRIF: ETV4 Mediated Tumor-Associated Neutrophil Infiltration Facilitates Lymphangiogenesis and Lymphatic Metastasis of Bladder Cancer.
- A homozygous truncating ETV4 variant in a Nigerian family with congenital anomalies of the kidney and urinary tract.
Kolvenbach, American journal of medical genetics. Part A 2023 - GeneRIF: A homozygous truncating ETV4 variant in a Nigerian family with congenital anomalies of the kidney and urinary tract.
- Identification and characterization of novel ETV4 splice variants in prostate cancer.
Cosi, Scientific reports 2023 - GeneRIF: Identification and characterization of novel ETV4 splice variants in prostate cancer.
- More
NP_001101769 ETS translocation variant 4 from Rattus norvegicus
62% identity, 18% coverage
- Expression of Pea3 protein subfamily members in hippocampus and potential regulation following neuronal stimulation.
Kandemir, Neuroscience letters 2020 (PubMed)- GeneRIF: Expression of Pea3 protein subfamily members in hippocampus and potential regulation following neuronal stimulation.
- Pea3 Transcription Factors, Etv4 and Etv5, Are Required for Proper Hippocampal Dendrite Development and Plasticity.
Fontanet, Cerebral cortex (New York, N.Y. : 1991) 2018 (PubMed)- GeneRIF: This study demonstrates that Etv4 and Etv5 transcription factors are expressed in hippocampal pyramidal neurons during the main period of dendritogenesis; reveals a novel role for Etv4 and Etv5 transcription factors for hippocampal circuit development and the coordination of synaptic maturation; and indicates that both factors are essential in the transcriptional program linking BDNF signaling to dendrite development.
- Pea3 transcription factor family members Etv4 and Etv5 mediate retrograde signaling and axonal growth of DRG sensory neurons in response to NGF.
Fontanet, The Journal of neuroscience : the official journal of the Society for Neuroscience 2013 - GeneRIF: these data establish Etv4 and Etv5 as essential molecules of the transcriptional program linking neurotrophin signaling to sensory neuronal differentiation
- Suppression subtractive hybridization analysis of gene expression during late kidney development identifies the developmentally regulated gene rPEA3.
Chen, Nephron. Experimental nephrology 2009 (PubMed)- GeneRIF: Newly identified gene rat PEA3 may play an important role in kidney development and differentiation.
- Putative regulation of expression of members of the Ets variant 4 transcription factor family and their downstream targets in the rat epididymis.
Yang, Biology of reproduction 2006 (PubMed)- GeneRIF: The data suggest that ETV4 family members regulate their own expression, and that they regulate transcription of a subset of genes that are dependent upon testicular luminal fluid factors.
- PEA3 transactivates the Muc4/sialomucin complex promoter in mammary epithelial and tumor cells.
Perez, The Journal of biological chemistry 2003 (PubMed)- GeneRIF: expression of PEA3 in mammary tumors leads to up-regulation of Muc4/SMC transcription, the gene product of which may contribute to the metastatic potential of mammary tumors.
ETV4_HUMAN / P43268 ETS translocation variant 4; Adenovirus E1A enhancer-binding protein; E1A-F; Polyomavirus enhancer activator 3 homolog; Protein PEA3 from Homo sapiens (Human) (see 3 papers)
62% identity, 18% coverage
- function: Transcriptional activator (PubMed:19307308, PubMed:31552090). May play a role in keratinocyte differentiation (PubMed:31552090).
function: (Microbial infection) Binds to the enhancer of the adenovirus E1A gene and acts as a transcriptional activator; the core-binding sequence is 5'-[AC]GGA[AT]GT-3'. - ATXN1 N-terminal region explains the binding differences of wild-type and expanded forms
Rocha, BMC medical genomics 2019 - “...Q8N5I4); DHX37 (57647; Q8IY37); DIXDC1 (85458; Q155Q3); EIF3F (8665; O00303); ESRRA (2101; P11474); ETV4 (2118; P43268); FAM46B (115572; Q96A09); FAR1 (84188; Q8WVX9); FOSL1 (8061; P15407); GATAD1 (57798; Q8WUU5); HEY2 (23493; Q9UBP5); HEYL (26508; Q9NQ87); HNRPLL (92906; Q8WVV9); ILVBL (10994; A1L0T0); IMMT (10989; Q16891); KCTD15 (79047; Q96SI1);...”
- “...P08243); CAMK2B (816; Q13554); DHX37 (57647; Q8IY37); DIXDC1 (85458; Q155Q3); EIF3F (8665; O00303); ETV4 (2118; P43268); HEYL (26508; Q9NQ87); ILVBL (10994; A1L0T0); MAGEB18 (286514; Q96M61); MAGEB2 (4113; O15479); MAGEB6 (158809; Q8N7X4); WBSCR16 (81554; Q96I51) expanded no preference ARID5A (10865; Q03989); CHRNA7 (1139; P36544); FOSL1 (8061; P15407);...”
- Reduced dosage of ERF causes complex craniosynostosis in humans and mice and links ERK1/2 signaling to regulation of osteogenesis.
Twigg, Nature genetics 2013 - “...proteins (Swissprot): ERF, P50548; SPI1, P17947; ETV6, P41212; ELF3; P78545; ELF1, P32519; SPDEF, O95238; ETV4, P43268; ELK1, P19419; ETS1, P14921; ETV2, O00321; ERG, P11308; GABP, Q06546. Erf ChIP-Seq data: GSE42936 (GEO). References 1 Plotnikov A Zehorai E Procaccia S Seger R The MAPK cascades: signaling components,...”
- Acetylation Increases EWS-FLI1 DNA Binding and Transcriptional Activity.
Schlottmann, Frontiers in oncology 2012 - “...ETS2 (P15036), ETV6 (P41212), ETV7 (Q9Y603), SPIB (Q01892), SPI1 (P17947), ETV1 (P50549), ETV5 (P41161), ETV4 (P43268), ERG (P11308), FLI1 (Q01543), FEV (Q99581), and ETV2 (O00321) were aligned using UniProt, to reveal conservation of Lysine positions K240, K252, K380, and K397. (C,D) Acetylation mutants were in vitro...”
- PDSM, a motif for phosphorylation-dependent SUMO modification.
Hietakangas, Proceedings of the National Academy of Sciences of the United States of America 2006
XP_015154938 ETS translocation variant 4 isoform X3 from Gallus gallus
61% identity, 20% coverage
NP_001023051 ETS domain-containing protein from Caenorhabditis elegans
71% identity, 19% coverage
- Integration of EGFR and LIN-12/Notch Signaling by LIN-1/Elk1, the Cdk8 Kinase Module, and SUR-2/Med23 in Vulval Precursor Cell Fate Patterning in Caenorhabditis elegans.
Underwood, Genetics 2017 - GeneRIF: we investigate orthologs of a transcription complex that acts in mammalian EGFR signaling-lin-1/Elk1, sur-2/Med23, and the Cdk8 Kinase module (CKM).our analysis using cell fate reporters reveals that both EGFR and LIN-12/Notch signal transduction pathways are active in all VPCs in lin-1/Elk1 mutants
- Conversion of the LIN-1 ETS protein of Caenorhabditis elegans from a SUMOylated transcriptional repressor to a phosphorylated transcriptional activator.
Leight, Genetics 2015 - GeneRIF: A model is proposed in which LIN-1 recruits multiple transcriptional repressors to inhibit the 1 degrees vulval cell fate, and phosphorylation by ERK converts LIN-1 to a transcriptional activator that promotes the 1 degrees vulval cell fate.
- Allele-specific suppressors of lin-1(R175Opal) identify functions of MOC-3 and DPH-3 in tRNA modification complexes in Caenorhabditis elegans.
Kim, Genetics 2010 - GeneRIF: Data show that loss-of-function mutations of moc-3 and dph-3 effectively suppress the Multivulva (Muv) phenotype of the lin-1(e1275, R175Opal) mutation.
- The Mi-2 nucleosome-remodeling protein LET-418 is targeted via LIN-1/ETS to the promoter of lin-39/Hox during vulval development in C. elegans.
Guerry, Developmental biology 2007 (PubMed)- GeneRIF: the interaction between LIN-1 and LET-418/Mi-2 may link RTK/Ras signaling with chromatin remodeling and gene expression
- Identification of cis-regulatory elements from the C. elegans Hox gene lin-39 required for embryonic expression and for regulation by the transcription factors LIN-1, LIN-31 and LIN-39.
Wagmaister, Developmental biology 2006 (PubMed)- GeneRIF: lin-39 is a direct target of the Ras pathway acting via LIN-1 and LIN-31
- Sumoylation of LIN-1 promotes transcriptional repression and inhibition of vulval cell fates.
Leight, Development (Cambridge, England) 2005 (PubMed)- GeneRIF: sumoylation of LIN-1 mediates an interaction with MEP-1 that contributes to transcriptional repression of genes that promote vulval cell fates
- lin-1 has both positive and negative functions in specifying multiple cell fates induced by Ras/MAP kinase signaling in C. elegans.
Tiensuu, Developmental biology 2005 (PubMed)- GeneRIF: lin-1 is required positively for the proper expression of several genes regulated by the pathway in cells adopting the 1 degrees cell fate.
- Identification of residues of the Caenorhabditis elegans LIN-1 ETS domain that are necessary for DNA binding and regulation of vulval cell fates.
Miley, Genetics 2004 - GeneRIF: The identification of multiple mutations that reduce the function of lin-1 as an inhibitor of the primary vulval cell fate and also reduce DNA binding suggest that DNA binding is essential for LIN-1 function in Caenorhabditis.
ETV4_DANRE / Q9PUQ1 ETS translocation variant 4; Polyomavirus enhancer activator 3 homolog; Protein PEA3 from Danio rerio (Zebrafish) (Brachydanio rerio) (see 4 papers)
61% identity, 18% coverage
- function: Transcriptional activator that binds to the (5'-CCGGA[AT]-3') motif. May control the acquisition of specific cell fates at an early stage during development of the somites and nervous system. May mediate the cellular effects of the fibroblast growth factors on embryogenesis
XP_009304861 ETS translocation variant 4 isoform X1 from Danio rerio
60% identity, 18% coverage
XP_005157691 ETS translocation variant 1 isoform X1 from Danio rerio
60% identity, 18% coverage
NP_001315521 ETS translocation variant 5a isoform 2 from Danio rerio
60% identity, 17% coverage
ETV1_MOUSE / P41164 ETS translocation variant 1; Ets-related protein 81 from Mus musculus (Mouse) (see 2 papers)
60% identity, 18% coverage
- function: Transcriptional activator that binds to DNA sequences containing the consensus pentanucleotide 5'-CGGA[AT]-3' (PubMed:1340465). Required for olfactory dopaminergic neuron differentiation; may directly activate expression of tyrosine hydroxylase (TH) (PubMed:19287374).
disruption phenotype: Significant reduction in the number of tyrosine hydroxylase (TH)-positive cells in the olfactory bulb. - Mitochondrial Membrane Potential Regulates Nuclear Gene Expression in Macrophages Exposed to Prostaglandin E2.
Sanin, Immunity 2018 - “...ETV1 is regulated by m . Consistent with its annotation in curated databases (UniProt ID: P41164), we found ETV1 to be inherently nuclear-localized. With the caveat that we used an over-expression vector, this intimates that regulated movement between the cytoplasm and nucleus is not responsible for...”
Gm5454 ETS translocation variant 1-like from Mus musculus
60% identity, 18% coverage
- Altered vitamin B12 metabolism in the central nervous system is associated with the modification of ribosomal gene expression: new insights from comparative RNA dataset analysis
Mathew, Functional & integrative genomics 2023 - “...Etv1, Etv4, Sp100, Elk1, Elf5, IRC900814, Etv6, Etv3, Cenpb, Elf3, Elk4, Elf2, Etv5, Gm4881, Kdm2b, Gm5454, Pax4, Glis2, Elk3 Rat 21 D3ZXG8_RAT, Egr2, E2f3, Zfp161, Klf7, Klf14, Tcfap2d, LOC100363771, Gmeb2, Gmeb1, Sp6, Cxxc1, D3ZGU0_RAT, RGD1305899, Klf12, D3ZQL2_RAT, Klf4, D3ZLI0_RAT, Zfx, Egr4, Sp2 Transcription factors and Ribosome...”
- Analysis of the peroxisome proliferator-activated receptor-β/δ (PPARβ/δ) cistrome reveals novel co-regulatory role of ATF4
Khozoie, BMC genomics 2012 - “...high percentage (68.8 90.1%) of consensus binding sites for ELK3, ELK4, ERG, TS1, FLI1, and GM5454 were also found in ChIP-seq peaks in chromatin from wild-type keratinocytes for genes exhibiting a type II response (Figure 8 A). For genes exhibiting a type III response, a high...”
G7Y944 ETS translocation variant 1/4/5 (Fragment) from Clonorchis sinensis
59% identity, 32% coverage
- In silico prediction of secretory proteins of Opisthorchis viverrini, Clonorchis sinensis and Fasciola hepatica that target the host cell nucleus
Machicado, Heliyon 2021 - “...csin110788 + - G7YTV9 Transcription factor HES-4 9.60 37.08 protein dimerization activity csin103118 - + G7Y944 ETS translocation variant 1/4/5 6.66 29.96 sequence-specific DNA binding regulation of transcription, DNA-dependent nucleus sequence-specific DNA binding transcription factor activity DNA binding csin100942 - + G7Y4L2 STARP antigen 11.27 17.01...”
- “...G7YY80 Histone H3 H2KPV8 Zinc finger protein 629 G7Y7Y9 Peptidyl-prolyl isomerase E (Cyclophilin E) 4 G7Y944 ETS translocation variant 1/4/5 6.629E-05 sequence-specific DNA binding Not applicable G7YQ06 Protein giant G7YJK7 Homeobox protein MSX-2 G7YLP5 Visual system homeobox 1 5 G7Y944 ETS translocation variant 1/4/5 1.750E-04 DNA...”
ETV5_MOUSE / Q9CXC9 ETS translocation variant 5 from Mus musculus (Mouse) (see paper)
NP_076283 ETS translocation variant 5 from Mus musculus
59% identity, 17% coverage
- function: Binds to DNA sequences containing the consensus nucleotide core sequence 5'-GGAA.-3'.
subunit: Interacts (via C-terminal) with ZMYM5 (via N-terminal 120 amino acid region). - Sertoli Cell-Germ Cell Interactions Within the Niche: Paracrine and Juxtacrine Molecular Communications.
Hofmann, Frontiers in endocrinology 2022 - “...Mitogen-Activated Protein Kinase 7. Proliferation, differentiation, transcription regulation and development of Sertoli cells. 30 ETV5 Q9CXC9 Sertoli cells ETS Variant Transcription Factor 5 . Induces the production of chemokines and maintains SSC homing within the niche 42 , 60 , 61 ETV5 Q9CXC9 Spermatogonial stem cells...”
- ETV5 promotes lupus pathogenesis and follicular helper T cell differentiation by inducing osteopontin expression.
Park, Proceedings of the National Academy of Sciences of the United States of America 2024 - GeneRIF: ETV5 promotes lupus pathogenesis and follicular helper T cell differentiation by inducing osteopontin expression.
- ETV5 Regulates Hepatic Fatty Acid Metabolism Through PPAR Signaling Pathway.
Mao, Diabetes 2021 (PubMed)- GeneRIF: ETV5 Regulates Hepatic Fatty Acid Metabolism Through PPAR Signaling Pathway.
- Establishment of Etv5 gene knockout mice as a recipient model for spermatogonial stem cell transplantation.
Zhang, Biology open 2021 - GeneRIF: Establishment of Etv5 gene knockout mice as a recipient model for spermatogonial stem cell transplantation.
- Chromatin accessibility analysis identifies the transcription factor ETV5 as a suppressor of adipose tissue macrophage activation in obesity.
Hu, Cell death & disease 2021 - GeneRIF: Chromatin accessibility analysis identifies the transcription factor ETV5 as a suppressor of adipose tissue macrophage activation in obesity.
- Etv transcription factors functionally diverge from their upstream FGF signaling in lens development.
Garg, eLife 2020 - GeneRIF: Etv transcription factors functionally diverge from their upstream FGF signaling in lens development.
- Etv5 safeguards trophoblast stem cells differentiation from mouse EPSCs by regulating fibroblast growth factor receptor 2.
Zhu, Molecular biology reports 2020 (PubMed)- GeneRIF: Etv5 safeguards trophoblast stem cells differentiation from mouse EPSCs by regulating fibroblast growth factor receptor 2.
- ETV5 regulates GOAT/ghrelin system in an mTORC1-dependent manner.
Mao, Molecular and cellular endocrinology 2019 (PubMed)- GeneRIF: Study found that ETV5 increased acyl ghrelin but not its total production; through the enhanced expression of GOAT enzyme. ETV5 transactivated GOAT promoter, leading to the subsequent increase of its expression. mTORC1 signaling inhibited the expression of ETV5 which deficiency attenuated the effect of mTORC1 signaling on GOAT/ghrelin. Therefore, ETV5 is a new transcription factor regulating GOAT expression.
- The Capicua/ETS Translocation Variant 5 Axis Regulates Liver-Resident Memory CD8+ T-Cell Development and the Pathogenesis of Liver Injury.
Park, Hepatology (Baltimore, Md.) 2019 (PubMed)- GeneRIF: Derepression of Etv5 increases Hobit expression in Cic -deficient CD8+ T cells and consequently enhances CD8+ T memory cell formation in liver, thereby leading to liver injury.
- More
4uuvA / P43268 Structure of the DNA binding ets domain of human etv4 in complex with DNA (see paper)
61% identity, 93% coverage
NP_001156620 ETS translocation variant 1 isoform c from Homo sapiens
60% identity, 19% coverage
- Reduction of ETV1 is Identified as a Prominent Feature of Age-Related Cataract.
Qiu, Current eye research 2024 (PubMed)- GeneRIF: Reduction of ETV1 is Identified as a Prominent Feature of Age-Related Cataract.
- Transcription factor ETV1-induced lncRNA MAFG-AS1 promotes migration, invasion, and epithelial-mesenchymal transition of pancreatic cancer cells by recruiting IGF2BP2 to stabilize ETV1 expression.
Weng, Growth factors (Chur, Switzerland) 2023 (PubMed)- GeneRIF: Transcription factor ETV1-induced lncRNA MAFG-AS1 promotes migration, invasion, and epithelial-mesenchymal transition of pancreatic cancer cells by recruiting IGF2BP2 to stabilize ETV1 expression.
- ETV1 Positively Correlated With Immune Infiltration and Poor Clinical Prognosis in Colorectal Cancer.
Shen, Frontiers in immunology 2022 - GeneRIF: ETV1 Positively Correlated With Immune Infiltration and Poor Clinical Prognosis in Colorectal Cancer.
- HGF-mediated elevation of ETV1 facilitates hepatocellular carcinoma metastasis through upregulating PTK2 and c-MET.
Zhang, Journal of experimental & clinical cancer research : CR 2022 - GeneRIF: HGF-mediated elevation of ETV1 facilitates hepatocellular carcinoma metastasis through upregulating PTK2 and c-MET.
- Identification of regulatory mRNA and microRNA for differentiation into cementoblasts and periodontal ligament cells.
Iwata, Journal of periodontal research 2021 (PubMed)- GeneRIF: Identification of regulatory mRNA and microRNA for differentiation into cementoblasts and periodontal ligament cells.
- A novel PTPRZ1-ETV1 fusion in gliomas.
Matjašič, Brain pathology (Zurich, Switzerland) 2020 - GeneRIF: A novel PTPRZ1-ETV1 fusion in gliomas.
- Clonal evaluation of early onset prostate cancer by expression profiling of ERG, SPINK1, ETV1, and ETV4 on whole-mount radical prostatectomy tissue.
Lu, The Prostate 2020 (PubMed)- GeneRIF: ERG overexpression was observed in 85 of 151 (56%) cases, followed by SPINK1 in 61 of 151 (40%), ETV1 in 9 of 149 (6%), and ETV4 in 4 of 141 (3%). There were 25 of 151 (17%) cases showing both ERG and SPINK1 overexpression within different regions of either the same tumor focus or different foci.
- Frequent copy number gains of SLC2A3 and ETV1 in testicular embryonal carcinomas.
Hoff, Endocrine-related cancer 2020 - GeneRIF: Frequent copy number gains of SLC2A3 and ETV1 in testicular embryonal carcinomas.
- More
ETV1_HUMAN / P50549 ETS translocation variant 1; Ets-related protein 81 from Homo sapiens (Human) (see 5 papers)
60% identity, 18% coverage
- function: Transcriptional activator that binds to DNA sequences containing the consensus pentanucleotide 5'-CGGA[AT]-3' (PubMed:7651741). Required for olfactory dopaminergic neuron differentiation; may directly activate expression of tyrosine hydroxylase (TH) (By similarity).
- Count Dracula Resurrected: Proteomic Analysis of Vlad III the Impaler's Documents by EVA Technology and Mass Spectrometry.
Pittalà, Analytical chemistry 2023 - “...of eccrine sweat glands) YES YES x x QKENAGEDPGLAR C TriOx YDPEAASAPGSGNPCHEASAAQKENAGEDPGLAR ASAAQKENAGEDPGLAR SAAQKENAGEDPGLAR ETV1 P50549 ETS translocation variant 1 AFPAHLPPSQSIPDSSYPMDHR M ox NA x MDGFYDQQVPYMVTNSQRGR 2 M ox 2 Y DOPA AHNAK Q09666 neuroblast differentiation-associated protein AHNAK MPDMHFKAPNISMPDVDLNLK 2 M ox low tissue specificity (including...”
- Defined PEG smears as an alternative approach to enhance the search for crystallization conditions and crystal-quality improvement in reduced screens.
Chaikuad, Acta crystallographica. Section D, Biological crystallography 2015 - “...with inhibitor ERK2VTX-11e complex P28482 41.5 28, 47 MMW ETS translocation variant 1 ETV1DNA complex P50549 12.4 5, 31, 39, 40, 49, 52, 53, 55, 57, 62, 68, 73, 78, 79, 81, 83, 84, 85, 89, 92, 93, 96 LMW, MMW, HMW, BMW Guanylate cyclase soluble...”
- Expressing the human proteome for affinity proteomics: optimising expression of soluble protein domains and in vivo biotinylation.
Keates, New biotechnology 2012 - “...identity to human Bin1 [21] CNO/ Q9NUP1 2/7 0/9 5/7 3/7 (aa1217) None reported ETV1/ P50549 5/8 0 7/7 7/7 PEA3, ETS-N-terminal domain (aa223326) Short homology to ets-1 HCK (SH2-SH3)/ P08631 6/8 2/8 5/8 4/7 SH3 domain (aa72138) Structure solved (PDB:3NHN) [22] HMHA1/ Q8IYN3 3/13 (weak)...”
- Acetylation Increases EWS-FLI1 DNA Binding and Transcriptional Activity.
Schlottmann, Frontiers in oncology 2012 - “...sequences of ETS1 (P14921), ETS2 (P15036), ETV6 (P41212), ETV7 (Q9Y603), SPIB (Q01892), SPI1 (P17947), ETV1 (P50549), ETV5 (P41161), ETV4 (P43268), ERG (P11308), FLI1 (Q01543), FEV (Q99581), and ETV2 (O00321) were aligned using UniProt, to reveal conservation of Lysine positions K240, K252, K380, and K397. (C,D) Acetylation...”
- PDSM, a motif for phosphorylation-dependent SUMO modification.
Hietakangas, Proceedings of the National Academy of Sciences of the United States of America 2006
NP_001100552 ETS translocation variant 5 from Rattus norvegicus
59% identity, 17% coverage
- ETV5 regulates proliferation and cell cycle genes in the INS-1 (832/13) cell line independently of the concentration of secreted insulin.
Díaz-López, FEBS open bio 2023 - GeneRIF: ETV5 regulates proliferation and cell cycle genes in the INS-1 (832/13) cell line independently of the concentration of secreted insulin.
- Maternal undernutrition during pregnancy and lactation increases transcription factors, ETV5 and GDNF, and alters regulation of apoptosis and heat shock proteins in the testis of adult offspring in the rat.
Pedrana, Reproduction, fertility, and development 2021 (PubMed)- GeneRIF: Maternal undernutrition during pregnancy and lactation increases transcription factors, ETV5 and GDNF, and alters regulation of apoptosis and heat shock proteins in the testis of adult offspring in the rat.
- Pea3 Transcription Factors, Etv4 and Etv5, Are Required for Proper Hippocampal Dendrite Development and Plasticity.
Fontanet, Cerebral cortex (New York, N.Y. : 1991) 2018 (PubMed)- GeneRIF: This study demonstrates that Etv4 and Etv5 transcription factors are expressed in hippocampal pyramidal neurons during the main period of dendritogenesis; reveals a novel role for Etv4 and Etv5 transcription factors for hippocampal circuit development and the coordination of synaptic maturation; and indicates that both factors are essential in the transcriptional program linking BDNF signaling to dendrite development.
- AAV-mediated gene transfer of the obesity-associated gene Etv5 in rat midbrain does not affect energy balance or motivated behavior.
Boender, PloS one 2014 - GeneRIF: gene transfer of Etv5 in the VTA/SNpc did not affect measures of energy balance or performances in a progressive ratio schedule
- Pea3 transcription factor family members Etv4 and Etv5 mediate retrograde signaling and axonal growth of DRG sensory neurons in response to NGF.
Fontanet, The Journal of neuroscience : the official journal of the Society for Neuroscience 2013 - GeneRIF: these data establish Etv4 and Etv5 as essential molecules of the transcriptional program linking neurotrophin signaling to sensory neuronal differentiation
- Expression of new loci associated with obesity in diet-induced obese rats: from genetics to physiology.
Gutierrez-Aguilar, Obesity (Silver Spring, Md.) 2012 (PubMed)- GeneRIF: Long-Evans rats maintained on chow or a high-fat diet (HFD) for 6 weeks. From a total of 19 genes analyzed, seven genes (ETV5, FTO, GNPDA2, KCTD15, TMEM18, MC4R, and SH2B1) were down-regulated in the hypothalamus of HFD compared to chow-fed rats
- Putative regulation of expression of members of the Ets variant 4 transcription factor family and their downstream targets in the rat epididymis.
Yang, Biology of reproduction 2006 (PubMed)- GeneRIF: The data suggest that ETV4 family members regulate their own expression, and that they regulate transcription of a subset of genes that are dependent upon testicular luminal fluid factors.
XP_015136780 ETS translocation variant 1 isoform X1 from Gallus gallus
60% identity, 18% coverage
ETV5_HUMAN / P41161 ETS translocation variant 5; Ets-related protein ERM from Homo sapiens (Human) (see 3 papers)
NP_004445 ETS translocation variant 5 from Homo sapiens
59% identity, 17% coverage
- function: Binds to DNA sequences containing the consensus nucleotide core sequence 5'-GGAA.-3'.
subunit: Interacts (via C-terminal) with ZMYM5 (via N-terminal 120 amino acid region). - ETV5 facilitates tumor progression in head-neck squamous cell carcinoma.
Yu, Oral diseases 2024 (PubMed)- GeneRIF: ETV5 facilitates tumor progression in head-neck squamous cell carcinoma.
- YTHDF2 Is a Therapeutic Target for HCC by Suppressing Immune Evasion and Angiogenesis Through ETV5/PD-L1/VEGFA Axis.
Wen, Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 - GeneRIF: YTHDF2 Is a Therapeutic Target for HCC by Suppressing Immune Evasion and Angiogenesis Through ETV5/PD-L1/VEGFA Axis.
- ETV5 promotes lupus pathogenesis and follicular helper T cell differentiation by inducing osteopontin expression.
Park, Proceedings of the National Academy of Sciences of the United States of America 2024 - GeneRIF: ETV5 promotes lupus pathogenesis and follicular helper T cell differentiation by inducing osteopontin expression.
- E26 transformation-specific transcription variant 5 in development and cancer: modification, regulation and function.
Wei, Journal of biomedical science 2023 - GeneRIF: E26 transformation-specific transcription variant 5 in development and cancer: modification, regulation and function.
- ETV5 transcriptionally activates TGFβ1 and promotes cancer cell invasion and migration of NSCLC.
Li, Journal of molecular histology 2023 (PubMed)- GeneRIF: ETV5 transcriptionally activates TGFbeta1 and promotes cancer cell invasion and migration of NSCLC.
- Human Islet MicroRNA-200c Is Elevated in Type 2 Diabetes and Targets the Transcription Factor ETV5 to Reduce Insulin Secretion.
Ofori, Diabetes 2022 - GeneRIF: Human Islet MicroRNA-200c Is Elevated in Type 2 Diabetes and Targets the Transcription Factor ETV5 to Reduce Insulin Secretion.
- ETV5 overexpression promotes progression of esophageal squamous cell carcinoma by upregulating SKA1 and TRPV2.
Sun, International journal of medical sciences 2022 - GeneRIF: ETV5 overexpression promotes progression of esophageal squamous cell carcinoma by upregulating SKA1 and TRPV2.
- The role of E26 transformation-specific variant transcription factor 5 in colorectal cancer cell proliferation and cell cycle progression.
Peng, Cell death & disease 2021 - GeneRIF: The role of E26 transformation-specific variant transcription factor 5 in colorectal cancer cell proliferation and cell cycle progression.
- More
- Tumour-associated antigenic peptides are present in the HLA class I ligandome of cancer cell line derived extracellular vesicles.
Kumar, Immunology 2022 - The Transcription Factor ETV5 Mediates BRAFV600E-Induced Proliferation and TWIST1 Expression in Papillary Thyroid Cancer Cells
Puli, Neoplasia (New York, N.Y.) 2018 - “...both ETV5 isoforms produced by alternative splicing at kDa 57.8 and kDa 62.4 (UNIPROT ID P41161 - 1 and P41161 -2). Further, exposure to 1.0M vemurafenib, a potent and specific inhibitor of BRAF (V600E), caused a significant downregulation of ETV5 expression at the mRNA level (...”
- Expression, Localization of SUMO-1, and Analyses of Potential SUMOylated Proteins in Bubalus bubalis Spermatozoa
Brohi, Frontiers in physiology 2017 - “...2-like 16 SC K212 SC-Direct M. musculus [(P15806), Mitf (Q08874), Ncor1 (Q60974)]- Homo sapiens [ETV5 (P41161), MITF (075030), TFE3 (P19532)]-S.cerevisiae [SGS1 (P35187)] 17 Dynein heavy chain 2, axonemal 3 SI AA 4266-4269 SIM Type Epstein-Barr virus [(POC6Z8), BGLF4(P13288)] CT,N,EC Z 17 Dynein heavy chain 2, axonemal...”
- Acetylation Increases EWS-FLI1 DNA Binding and Transcriptional Activity.
Schlottmann, Frontiers in oncology 2012 - “...ETS1 (P14921), ETS2 (P15036), ETV6 (P41212), ETV7 (Q9Y603), SPIB (Q01892), SPI1 (P17947), ETV1 (P50549), ETV5 (P41161), ETV4 (P43268), ERG (P11308), FLI1 (Q01543), FEV (Q99581), and ETV2 (O00321) were aligned using UniProt, to reveal conservation of Lysine positions K240, K252, K380, and K397. (C,D) Acetylation mutants were...”
- PDSM, a motif for phosphorylation-dependent SUMO modification.
Hietakangas, Proceedings of the National Academy of Sciences of the United States of America 2006
XP_005165918 ETS translocation variant 5b isoform X2 from Danio rerio
59% identity, 17% coverage
XP_018124693 ETS translocation variant 1 isoform X1 from Xenopus laevis
60% identity, 18% coverage
NP_001122332 Ets protein from Ciona intestinalis
61% identity, 12% coverage
ETS5_CAEEL / Q18579 ETS domain-containing transcription factor ets-5 from Caenorhabditis elegans (see 4 papers)
64% identity, 38% coverage
- function: Transcription factor that plays a role in the differentiation and function of the CO(2)- and O(2)-sensing BAG neurons (PubMed:21954162, PubMed:22479504, PubMed:30890567). The BAG neurons are required for the behavioral avoidance of environmental CO(2) and the sensing of decreased O(2) levels (PubMed:21954162, PubMed:22479504, PubMed:28193866). Promotes the expression of genes that play a role in CO(2)- and O(2)-sensing and in egg-laying in the BAG neurons (PubMed:21954162). Positively regulates the transcription of the receptor-type guanylate cyclase gcy-9, which is a critical component of the CO(2) transduction pathway, in the BAG neurons (PubMed:22479504). May mediate transcriptional activation by binding to the motif 5'- ACTTCCG-3' (PubMed:22479504, PubMed:30890567). Acts in the BAG and ASG neurons to regulate intestinal fat levels and to promote exploratory behavior, possibly by regulating neuropeptidergic signaling (PubMed:28193866).
disruption phenotype: Lack of CO(2) avoidance behavior (PubMed:21954162, PubMed:22479504). Down-regulation of genes required for BAG neuron differentiation and function (PubMed:21954162, PubMed:22479504). Reduction in exploratory behavior and an increase of animals in the quiescent state (PubMed:28193866). Unable to sense downsteps of O(2) (PubMed:28193866). Increased intestinal fat storage (PubMed:28193866).
NP_001263956 ETS domain-containing protein from Caenorhabditis elegans
64% identity, 33% coverage
ETS3_DROME / P29774 DNA-binding protein D-ETS-3 from Drosophila melanogaster (Fruit fly) (see paper)
62% identity, 16% coverage
LOC663364 DNA-binding protein D-ETS-6 from Tribolium castaneum
62% identity, 16% coverage
NP_651286 Ets96B, isoform C from Drosophila melanogaster
55% identity, 14% coverage
ET96B_DROME / Q8MRW5 ETV5-related protein Ets96B from Drosophila melanogaster (Fruit fly) (see paper)
55% identity, 14% coverage
- function: Required in dopaminergic neurons to regulate expression of genes involved in dopamine signaling. Decreases expression of the dopamine transporter DAT and increases expression of the dopamine transporter Vmat and the tyrosine 3-monooxygenase ple which is involved in dopamine biosynthesis. Also involved in negatively regulating the expression of a group of endoplasmic reticulum proteins, the molecular chaperone Calr and the protein disulfide isomerases CaBP1 and ERp60.
disruption phenotype: RNAi-mediated knockdown in the central nervous system (CNS) during development increases the expression of CaBP1, Calr and ERp60 and regulates expression of other genes involved in a variety of processes including oxidative phosphorylation and redox reactions, lipid and sugar homeostasis, and translation. It increases susceptibility to starvation but has no effect on feeding behavior. It increases triacylglyceride (TAG) levels in normal-fed flies but has no effect on TAG levels 12 or 24 hours after starvation. It also induces a heightened startle-response, increases hyperactivity and reduces sleep. RNAi-mediated knockdown specifically in dopaminergic neurons throughout development influences the expression of genes involved in dopamine signaling by increasing expression of ple and Vmat and decreasing expression of DAT. It also recapitulates the effects seen following CNS knockdown, namely increased susceptibility to starvation, heightened startle-response and reduced sleep. RNAi-mediated knockdown specifically in the adult CNS increases resistance to starvation with no effect on feeding behavior, decreases TAG levels in normal-fed flies and has no effect on hyperactivity or sleep.
ERG_MOUSE / P81270 Transcriptional regulator ERG from Mus musculus (Mouse) (see paper)
61% identity, 16% coverage
- function: Transcriptional regulator. May participate in transcriptional regulation through the recruitment of SETDB1 histone methyltransferase and subsequent modification of local chromatin structure
subunit: Identified in a IGF2BP1-dependent mRNP granule complex containing untranslated mRNAs. Interacts with SETDB1.
ETS6_DROME / P29776 DNA-binding protein D-ETS-6 from Drosophila melanogaster (Fruit fly) (see paper)
NP_001285547 Ets at 21C, isoform C from Drosophila melanogaster
61% identity, 17% coverage
- Hippo signaling promotes Ets21c-dependent apical cell extrusion in the Drosophila wing disc.
Ai, Development (Cambridge, England) 2020 (PubMed)- GeneRIF: Hippo signaling promotes Ets21c-dependent apical cell extrusion in the Drosophila wing disc.
- Ets21c Governs Tissue Renewal, Stress Tolerance, and Aging in the Drosophila Intestine.
Mundorf, Cell reports 2019 - GeneRIF: Ets21c controls ISC proliferation as well as EC apoptosis through distinct sets of target genes that orchestrate cellular behaviors via intrinsic and non-autonomous signaling mechanisms.
- The transcription factor Ets21C drives tumor growth by cooperating with AP-1.
Toggweiler, Scientific reports 2016 - GeneRIF: Data show that Ets21C has a crucial role in the regulation of tumor growth as a loss of function critically reduced tumor growth, whereas an excess of Ets21C further increased tumor size. While Ets21C was shown only with a role in fine-tuning the transcriptional program of neoplastic tumors, results point towards a more fundamental role as activator of a specific set of target genes driving tumor growth and invasion.
- Interplay among Drosophila transcription factors Ets21c, Fos and Ftz-F1 drives JNK-mediated tumor malignancy.
Külshammer, Disease models & mechanisms 2015 - GeneRIF: malignant transformation of the ras(V12)scrib(1) tumors requires bZIP protein Fos, the ETS-domain factor Ets21c and the nuclear receptor Ftz-F1, all acting downstream of Jun-N-terminal kinase.
- EGFR/Ras Signaling Controls Drosophila Intestinal Stem Cell Proliferation via Capicua-Regulated Genes.
Jin, PLoS genetics 2015 - GeneRIF: These studies identify Cic, Pnt, and Ets21C as critical downstream effectors of EGFR signaling in Drosophila Intestinal Stem Cells
NP_001008616 transcriptional regulator ERG from Danio rerio
61% identity, 19% coverage
A8MZ24 ETS transcription factor ERG from Homo sapiens
61% identity, 17% coverage
NP_001289081 transcriptional regulator ERG isoform 2 from Mus musculus
61% identity, 17% coverage
- ERG mediates the inhibition of NK cell cytotoxicity through the HLX/STAT4/Perforin signaling pathway, thereby promoting the progression of myocardial infarction.
Guo, Journal of physiology and biochemistry 2024 (PubMed)- GeneRIF: ERG mediates the inhibition of NK cell cytotoxicity through the HLX/STAT4/Perforin signaling pathway, thereby promoting the progression of myocardial infarction.
- ERG Regulates Lymphatic Vessel Specification Genes and Its Deficiency Impairs Wound Healing-Associated Lymphangiogenesis.
Yamashita, Arthritis & rheumatology (Hoboken, N.J.) 2024 - GeneRIF: ERG Regulates Lymphatic Vessel Specification Genes and Its Deficiency Impairs Wound Healing-Associated Lymphangiogenesis.
- EVI1 exerts distinct roles in AML via ERG and cyclin D1 promoting a chemoresistant and immune-suppressive environment.
Masamoto, Blood advances 2023 - GeneRIF: EVI1 exerts distinct roles in AML via ERG and cyclin D1 promoting a chemoresistant and immune-suppressive environment.
- ERG Functionally Overlaps with Other Ets Proteins in Promoting TH9 Cell Expression of Il9 during Allergic Lung Inflammation.
Kharwadkar, Journal of immunology (Baltimore, Md. : 1950) 2023 - GeneRIF: ERG Functionally Overlaps with Other Ets Proteins in Promoting TH9 Cell Expression of Il9 during Allergic Lung Inflammation.
- Cytokine-Mediated Degradation of the Transcription Factor ERG Impacts the Pulmonary Vascular Response to Systemic Inflammatory Challenge.
Schafer, Arteriosclerosis, thrombosis, and vascular biology 2023 - GeneRIF: Cytokine-Mediated Degradation of the Transcription Factor ERG Impacts the Pulmonary Vascular Response to Systemic Inflammatory Challenge.
- Oxidative Stress Induces E-Selectin Expression through Repression of Endothelial Transcription Factor ERG.
Zhang, Journal of immunology (Baltimore, Md. : 1950) 2023 - GeneRIF: Oxidative Stress Induces E-Selectin Expression through Repression of Endothelial Transcription Factor ERG.
- SND1 binds to ERG and promotes tumor growth in genetic mouse models of prostate cancer.
Liao, Nature communications 2023 - GeneRIF: SND1 binds to ERG and promotes tumor growth in genetic mouse models of prostate cancer.
- ETS-related gene (ERG) undermines genome stability in mouse prostate progenitors via Gsk3β dependent Nkx3.1 degradation.
Lorenzoni, Cancer letters 2022 - GeneRIF: ETS-related gene (ERG) undermines genome stability in mouse prostate progenitors via Gsk3beta dependent Nkx3.1 degradation.
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ERG_HUMAN / P11308 Transcriptional regulator ERG; Transforming protein ERG from Homo sapiens (Human) (see 5 papers)
61% identity, 17% coverage
- function: Transcriptional regulator. May participate in transcriptional regulation through the recruitment of SETDB1 histone methyltransferase and subsequent modification of local chromatin structure
subunit: Identified in a IGF2BP1-dependent mRNP granule complex containing untranslated mRNAs. Interacts with SETDB1. - miR-4482 and miR-3912 aim for 3'UTR of ERG mRNA in prostate cancer.
Mumtaz, PloS one 2023 - “...It was mapped on chromosome 21 (21q22.2). It encodes a 54 kDa (kilo Dalton) protein (P11308) [ 1 ]. ETS proteins are nuclear DNA-binding phosphoproteins that act as activators or repressors of transcription [ 2 ]. ERG is expressed in endothelial cells (ECs) [ 3 ],...”
- Licorice extract inhibits growth of non-small cell lung cancer by down-regulating CDK4-Cyclin D1 complex and increasing CD8+ T cell infiltration
Zhu, Cancer cell international 2021 - “...Tubulin beta-1 chain TUBB1 5 Homo sapiens P12268 Inosine-5'-monophosphate dehydrogenase 2 IMPDH2 1 Homo sapiens P11308 Transcriptional regulator ERG ERG 1 Homo sapiens P45985 Dual specificity mitogen-activated protein kinase kinase 4 MAP2K4 1 Homo sapiens P25100 Alpha-1D adrenergic receptor ADRA1D 2 Homo sapiens P36544 Neuronal acetylcholine...”
- Allosteric interference in oncogenic FLI1 and ERG transactions by mithramycins.
Hou, Structure (London, England : 1993) 2021 - “...mutant ( Hou and Tsodikov, 2015 ) NCBI: Q01543 Human ERG (residues 306429) NCBI NCBI: P11308 Human Runx2 (residues 111233) NCBI NCBI: Q13950 Human Runx2 (residues 111287) NCBI NCBI: Q13950 Human Cbf (residues 1142) NCBI NCBI: Q13951 Deposited Data Coordinates/diffraction data: FLI1-DNA (16-mer) This study PDB:...”
- Identification of potential biomarkers and immune cell infiltration in acute myocardial infarction (AMI) using bioinformatics strategy.
Xie, Bioengineered 2021 - “...0.0345036 0.026288457 E7DVW4, P15090, I3WAC9, P01308 hsa05215 Prostate cancer 0.0345036 0.026288457 B2RBI8, P37275, I3WAC9, P01308, P11308 hsa04810 Regulation of actin cytoskeleton 0.049184985 0.037474274 Q8N8S7, P02751, Q6MZM7, Q9UQS6, P52735, I3WAC9, P01308 hsa04960 Aldosterone-regulated sodium reabsorption 0.049184985 0.037474274 I3WAC9, P01308, Q15599 hsa00982 Drug metabolism cytochrome P450 0.049184985 0.037474274...”
- Gene-methylation interactions: discovering region-wise DNA methylation levels that modify SNP-associated disease risk.
Romanowska, Clinical epigenetics 2020 - “...are predicted to bind to the sequence containing CpG cg03309455: ETS-related gene (ERG; uniprot ID: P11308) and Neurogenic differentiation factor 2 (NEUROD2; uniprot ID: Q15784). While ERG is a general factor expressed in 197 tissue types, according to a search in the bgee database ( https://bgee.org/?page=gene&gene_id=ENSG00000157554...”
- Comparative structure analysis of the ETSi domain of ERG3 and its complex with the E74 promoter DNA sequence.
Sharma, Acta crystallographica. Section F, Structural biology communications 2018 - Prediction of the anti-inflammatory mechanisms of curcumin by module-based protein interaction network analysis.
Gan, Acta pharmaceutica Sinica. B 2015 - “...SNCA P37840 PTGS2 a P35354 EHMT2 Q96KQ7 LMNA P02545 TARDBP Q13148 STAT3 a P40763 ERG P11308 MAPK1 P28482 TDP1 Q9NUW8 AHR P35869 ESR1 P03372 MAPT P10636 THRB P10828 ALDH1A1 P00352 FEN1 P39748 MBNL1 Q9NR56 TLR9 Q9NR96 ALOX12 P18054 GAA P10253 MLL Q03164 TP53 P04637 ALOX15 P16050...”
- 5' UTR control of native ERG and of Tmprss2:ERG variants activity in prostate cancer.
Zammarchi, PloS one 2013 - “...The structure is mainly based on the 11 exons of Refseq entry NM_004449.4 (Uniprot entry P11308 for ERG2), and incorporates the exon numbering used in the seminal Tomlins paper [2] , [22] first describing the Tmprss2:ERG fusion. In short, we maintained as exon 4 the 218nt...”
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A8MX39 ETS transcription factor ERG from Homo sapiens
61% identity, 18% coverage
B5MDW0 ETS transcription factor ERG from Homo sapiens
61% identity, 18% coverage
NP_999698 ets homolog from Strongylocentrotus purpuratus
60% identity, 14% coverage
Q01414 Transcriptional regulator ERG homolog (Fragment) from Lytechinus variegatus
61% identity, 46% coverage
- Active Notch signaling is required for arm regeneration in a brittle star
Mashanov, PloS one 2020 - “...GO:0006520cellular amino acid metabolic process 2.17 TRINITY_DN111554_c1_g1_i4 A7X3X8 C-type lectin lectoxin-Enh5 GO:0030246carbohydrate binding 6.7 TRINITY_DN88709_c0_g1_i1 Q01414 Transcriptional regulator ERG homolog GO:0003700DNA-binding transcription factor activity 5.90 TRINITY_DN105897_c0_g3_i1 Q8TQD0 Macrodomain-containing protein MA_1614 NA 5.62 TRINITY_DN91758_c0_g1_i1 C0HL13 Low-density lipoprotein receptor-related protein 2 GO:0006898receptor-mediated endocytosis 5.20 The down-regulated genes clustered...”
XP_005158257 fli-1 proto-oncogene, ETS transcription factor-related sequence isoform X3 from Danio rerio
60% identity, 16% coverage
LOC725629 DNA-binding protein D-ETS-6-like from Apis mellifera
61% identity, 25% coverage
- Transcriptomic Responses Underlying the High Virulence of Black Queen Cell Virus and Sacbrood Virus following a Change in Their Mode of Transmission in Honey Bees (Apis mellifera)
Al, Viruses 2023 - “...Table 3 ). Other genes that were either differentially upregulated (Y-e3, CPR1, LOC107964791, LOC100578352, and LOC725629) ( Table 2 ) or downregulated (Est-6, Eth, LOC406114, LOC100576797, and LOC408603) ( Table 3 ) in response to BQCV and SBV infection, whether or not the bees were exposed...”
- “...Signaling receptor activity - - 2.12 - LOC100578352 ionotropic receptor 75a-like - - 3.19 3.36 LOC725629 DNA-binding protein D-ETS-6-like - - 4.50 4.03 5-ht7 serotonin receptor 7 Signaling receptor activity - - - 2.42 CPR17 cuticular protein 17 Structural constituent of cuticle - - - 3.12...”
FEV_DANRE / A3FEM2 Protein FEV; Protein Pet-1 from Danio rerio (Zebrafish) (Brachydanio rerio) (see paper)
NP_001315078 protein FEV isoform 1 from Danio rerio
62% identity, 34% coverage
NP_001008780 Fli-1 proto-oncogene, ETS transcription factor-related sequence from Danio rerio
60% identity, 17% coverage
- The role of the ETS factor erg in zebrafish vasculogenesis
Ellett, Mechanisms of development 2009 - “...Numbers: zf Erg: BC086811.1; mm Erg: BAC34461; hu ERG: BC040168; zf Fli1a: AAH66571, zf Fli1b: NP_001008780; mm Fli1: NP_032052; mm FEV: NP_694751; mm ETS-1: NP_035938; zf Etsrp: AAY89037 and zf Spi1: NP_932328). Full-length sequence divergence analysis and domain-restricted alignments were performed with DNAstar Lasergene MegAlign. ETS...”
XP_018080116 ETS variant transcription factor 2L homeolog isoform X1 from Xenopus laevis
63% identity, 27% coverage
XP_005159335 Friend leukemia integration 1 transcription factor isoform X4 from Danio rerio
61% identity, 17% coverage
- Fli1 acts in parallel with Pu.1 to control macrophage and neutrophil fate in zebrafish.
Zhang, Journal of genetics and genomics = Yi chuan xue bao 2024 (PubMed)- GeneRIF: Fli1 acts in parallel with Pu.1 to control macrophage and neutrophil fate in zebrafish.
- Wnt signaling positively regulates endothelial cell fate specification in the Fli1a-positive progenitor population via Lef1.
Hübner, Developmental biology 2017 (PubMed)- GeneRIF: mesodermal Wnt3a-mediated signaling via the transcription factor Lef1 positively regulates EC specification (defined by kdrl expression) at the expense of primitive erythrocyte specification (defined by gata1 expression) in zebrafish embryos.
- Fli+ etsrp+ hemato-vascular progenitor cells proliferate at the lateral plate mesoderm during vasculogenesis in zebrafish.
Chun, PloS one 2011 - GeneRIF: Fli+ etsrp+ hemato-vascular progenitor cells proliferate at the lateral plate mesoderm during vasculogenesis in zebrafish.
- Loss of GATA1 and gain of FLI1 expression during thrombocyte maturation.
Jagadeeswaran, Blood cells, molecules & diseases 2010 - GeneRIF: These results showed that young thrombocytes have higher GATA1 promoter activity, while mature thrombocytes have more fli1 gene promoter transcription.
- Ewing sarcoma fusion protein EWSR1/FLI1 interacts with EWSR1 leading to mitotic defects in zebrafish embryos and human cell lines.
Embree, Cancer research 2009 - GeneRIF: Interaction between EWSR1/FLI1 and EWSR1 in Ewing sarcoma may induce mitotic defects leading to genomic instability and subsequent malignant transformation.
- Genome-wide analysis of the zebrafish ETS family identifies three genes required for hemangioblast differentiation or angiogenesis.
Liu, Circulation research 2008 (PubMed)- GeneRIF: fli1, and etsrp, demonstrated that erg and fli1 act cooperatively and are required for angiogenesis possibly via direct regulation of an endothelial cell junction molecule, VE-cadherin
FLI1_HUMAN / Q01543 Friend leukemia integration 1 transcription factor; Proto-oncogene Fli-1; Transcription factor ERGB from Homo sapiens (Human) (see 5 papers)
61% identity, 18% coverage
- function: Sequence-specific transcriptional activator (PubMed:24100448, PubMed:26316623, PubMed:28255014). Recognizes the DNA sequence 5'- C[CA]GGAAGT-3'.
subunit: Can form homodimers or heterodimers with ETV6/TEL1 - Hydrophilic Components as Key Active Ingredients in Adipose-Derived Matrix Bioscaffolds for Inducing Fat Regeneration.
Ma, Advanced healthcare materials 2024 - “...1.45926E06 1.053 18 Q15139 PRKD1 6.19 0.002079801 0.285 19 P60509 ERVPABLB1 6.14 2.1856E06 0.203 20 Q01543 FLI1 6.13 3.70133E05 0.794 21 Q6ZN30 BNC2 6.13 3.25991E06 0.612 22 Q6UWE0 LRSAM1 6.10 2.64352E05 0.585 23 Q14031 COL4A6 6.08 0.000116837 0.427 24 Q6IN85 PPP4R3A 6.05 2.17093E06 0.441 25 Q5SYE7...”
- Baseline Levels of Circulating Inflammatory Biomarkers Stratify Patients with Vitiligo Who Significantly Repigment after Treatment with Ruxolitinib Cream.
Howell, JID innovations : skin science from molecules to population health 2023 - “...0.61 CD160 CD160 antigen O88875 1.182 0.049 0.71 FLI1 Friend leukemia integration 1 transcription factor Q01543 1.179 0.026 0.61 S100A11 Protein S100-A11 P31949 1.166 0.033 0.63 TGFR-2 TGF- receptor type-2 P37173 1.163 0.036 0.63 PSME1 Proteasome activator complex subunit 1 Q06323 1.159 0.026 0.61 TRAIL-R2 TNF...”
- Nuclear Proteomics of Induced Leukemia Cell Differentiation.
Novikova, Cells 2022 - “...cyclin-B1 P14635 CCNB1 Cell cycle progression, p53 regulation + Friend leukemia integration 1 transcription factor Q01543 FLI1 MDM2 transcription regulation +(72 h) Mothers against decapentaplegic homolog 4 Q13485 SMAD4 MDM2 transcription regulation +(6, 12, and 72 h) Lupus La protein P05455 SSB MDM2 regulation + Serine-protein...”
- Allosteric interference in oncogenic FLI1 and ERG transactions by mithramycins.
Hou, Structure (London, England : 1993) 2021 - “...al., 2018 ) N/A Human FLI1 (residues 276375) ( Hou and Tsodikov, 2015 ) NCBI: Q01543 Human FLI1 (residues 276399) ( Hou and Tsodikov, 2015 ) NCBI: Q01543 Human FLI1 (residues 276399), F362A mutant ( Hou and Tsodikov, 2015 ) NCBI: Q01543 Human ERG (residues 306429)...”
- The Role of C-X-C Chemokine Receptor Type 4 (CXCR4) in Cell Adherence and Spheroid Formation of Human Ewing's Sarcoma Cells under Simulated Microgravity.
Romswinkel, International journal of molecular sciences 2019 - “...following gene were integrated into the STRING Network with their UniProtKB identifiers: EWSR1 Q01844), FLI1 (Q01543), CAV1 (Q03135), CXCR4 (P61073), DKK2 (Q9UBU2), VEGFA (P15692), CD44 (P16070), IGFLR1 (Q9H665), MMP9 (P14780), LOXL1 (Q08397), NKX2.2 (O95096), ZEB2 (O60315), ERBB4 (Q15303), ACKR3 (P25106), CD99 (P14209), CDH1 (P12830). The STRING...”
- Angiogenic and Immunologic Proteins Identified by Deep Proteomic Profiling of Human Retinal and Choroidal Vascular Endothelial Cells: Potential Targets for New Biologic Drugs.
Smith, American journal of ophthalmology 2018 - “...8.6255E-07 Lymphokine-activated killer T-cell-originated protein kinase Q96KB5 4.09 2.3746E-03 Friend leukemia integration 1 transcription factor Q01543 4.07 9.1066E-05 Cohesin subunit SA-2 Q8N3U4 4.04 2.6038E-03 Structural maintenance of chromosomes protein 4 (SMC protein 4; SMC-4) Q9NTJ3 3.92 4.8729E-08 Histone-lysine N-methyltransferase EHMT1 Q9H9B1 3.75 8.4456E-03 Condensin complex subunit...”
- Acetylation Increases EWS-FLI1 DNA Binding and Transcriptional Activity.
Schlottmann, Frontiers in oncology 2012 - “...ETV7 (Q9Y603), SPIB (Q01892), SPI1 (P17947), ETV1 (P50549), ETV5 (P41161), ETV4 (P43268), ERG (P11308), FLI1 (Q01543), FEV (Q99581), and ETV2 (O00321) were aligned using UniProt, to reveal conservation of Lysine positions K240, K252, K380, and K397. (C,D) Acetylation mutants were in vitro acetylated by CBP (C)...”
FLI1_MOUSE / P26323 Friend leukemia integration 1 transcription factor; Retroviral integration site protein Fli-1 from Mus musculus (Mouse) (see paper)
NP_032052 Friend leukemia integration 1 transcription factor isoform 1 from Mus musculus
61% identity, 18% coverage
- function: Sequence-specific transcriptional activator. Recognizes the DNA sequence 5'-C[CA]GGAAGT-3'.
subunit: Can form homodimers or heterodimers with ETV6/TEL1. - The role of the ETS factor erg in zebrafish vasculogenesis
Ellett, Mechanisms of development 2009 - “...BC086811.1; mm Erg: BAC34461; hu ERG: BC040168; zf Fli1a: AAH66571, zf Fli1b: NP_001008780; mm Fli1: NP_032052; mm FEV: NP_694751; mm ETS-1: NP_035938; zf Etsrp: AAY89037 and zf Spi1: NP_932328). Full-length sequence divergence analysis and domain-restricted alignments were performed with DNAstar Lasergene MegAlign. ETS DNA-binding domain restrictions...”
- NEAT1 inhibits the angiogenic activity of cerebral arterial endothelial cells by inducing the M1 polarization of microglia through the AMPK signaling pathway.
Chen, Cellular & molecular biology letters 2024 - “...P51908 Apobec1 apolipoprotein B mRNA editing enzyme, catalytic polypeptide 1 2.99 Q80WT5 Aftph Aftiphilin 2.89 P26323 Fli1 Friend leukemia integration 1 transcription factor 2.82 Table2 Information of top 20 down-regulated proteins Accession Gene Description Fold change (log2) Q8R0W0 Eppk1 Epiplakin 6.09 Q91VR8 Brk1 Protein BRICK1 5.41...”
- Identification of soluble protein fragments by gene fragmentation and genetic selection.
Dyson, Nucleic acids research 2008 - “...for protein solubility selections. The proto-oncogene Fli1 (Friend leukemia integration 1 transcription factor, UNIPROT accession P26323) was chosen as the initial target because previous studies showed that even when expressed with the N-terminal solubility enhancing fusions maltose binding-protein (MBP) and thioredoxin (Trx), extensive proteolytic cleavage of...”
- Production of soluble mammalian proteins in Escherichia coli: identification of protein features that correlate with successful expression
Dyson, BMC biotechnology 2004 - “...0.0 0.0 51 Gata2 O09100 GATA 2 275402/480 14.2 1.0 1.0 0.0 0.0 52 Fli1 P26323 SAM_PNT, Ets 2452/452 50.9 3.0 1.0 0.0 0.0 53 Fli1 P26323 SAM_PNT, Ets 2363/452 41.7 3.0 0.0 134.5 61.0 54 Fli1 P26323 SAM_PNT 2198/452 22.2 3.0 0.0 121.2 86.8 55...”
- “...1.0 61.0 38.2 56 Fli1 P26323 SAM+ETS 114363/452 29.4 3.0 0.0 96.5 73.1 57 Fli1 P26323 SAM_PNT 114196/452 10.0 3.0 0.0 71.8 51.7 58 Fli1 P26323 Ets 280452/452 20.1 3.0 1.0 28.6 16.3 59 Fli1 P26323 Ets 280363/452 10.9 3.0 0.0 23.4 23.0 60 Lmo2 P25801...”
B1PRL2 EWS/FLI fusion protein from Homo sapiens
61% identity, 16% coverage
FEV_HUMAN / Q99581 Protein FEV; Fifth Ewing variant protein; PC12 ETS domain-containing transcription factor 1; PC12 ETS factor 1; Pet-1 from Homo sapiens (Human) (see 5 papers)
NP_059991 protein FEV from Homo sapiens
61% identity, 34% coverage
- function: Functions as a transcriptional regulator. According to PubMed:12761502, it functions as a transcriptional repressor. Functions in the differentiation and the maintenance of the central serotonergic neurons. May play a role in cell growth.
- TMPRSS2-ERG fusion protein regulates insulin-like growth factor-1 receptor (IGF1R) gene expression in prostate cancer: involvement of transcription factor Sp1.
Meisel, Oncotarget 2016 - “...ETV6 P41212 5.912296 0.019847 BCCIP BRCA2 and CDKN1A-interacting protein Q9P287 4.570442 0.001063 FEV Protein FEV Q99581 4.39208 0.026563 EIF3M Eukaryotic translation initiation factor 3 subunit M Q7L2H7 3.941612 0.000997 CAV1 Caveolin-1;Caveolin Q03135 3.797178 0.004396 ZNF710 Zinc finger protein 710 Q8N1W2 3.739227 0.050713 ARMC8 Armadillo repeat-containing protein...”
- Acetylation Increases EWS-FLI1 DNA Binding and Transcriptional Activity.
Schlottmann, Frontiers in oncology 2012 - “...SPIB (Q01892), SPI1 (P17947), ETV1 (P50549), ETV5 (P41161), ETV4 (P43268), ERG (P11308), FLI1 (Q01543), FEV (Q99581), and ETV2 (O00321) were aligned using UniProt, to reveal conservation of Lysine positions K240, K252, K380, and K397. (C,D) Acetylation mutants were in vitro acetylated by CBP (C) or PCAF...”
- Tumor Suppressor Role and Clinical Significance of the FEV Gene in Prostate Cancer.
Liang, Disease markers 2022 - GeneRIF: Tumor Suppressor Role and Clinical Significance of the FEV Gene in Prostate Cancer.
- Ewing sarcoma with FEV gene rearrangements is a rare subset with predilection for extraskeletal locations and aggressive behavior.
Tsuda, Genes, chromosomes & cancer 2020 - GeneRIF: Ewing sarcoma with FEV gene rearrangements is a rare subset with predilection for extraskeletal locations and aggressive behavior.
- Association of genetic variations in the serotonin and dopamine systems with aggressive behavior in the Chinese adolescent population: Single- and multiple-risk genetic variants.
Chang, Journal of affective disorders 2018 (PubMed)- GeneRIF: This study adds to the growing evidence on the association of single- and multiple-risk variants in DRD3, DRD4, and FEV with aggressive behavior in Chinese adolescents.
- Expression of the fetal hematopoiesis regulator FEV indicates leukemias of prenatal origin.
Liu, Leukemia 2017 (PubMed)- GeneRIF: identified FEV is unique to fetal HSCs and stably expressed in leukemic cells of prenatal origin
- Association of 25-Hydroxyvitamin D status and genetic variation in the vitamin D metabolic pathway with FEV1 in the Framingham Heart Study.
Hansen, Respiratory research 2015 - GeneRIF: Genetic variation in FEV1 was associated with serum 25-Hydroxyvitamin D status.
- Fev regulates hematopoietic stem cell development via ERK signaling.
Wang, Blood 2013 (PubMed)- GeneRIF: Fev-ERK signaling is essential for hemogenic endothelium-based hematopoietic stem cell development.
- Convergent effects of mouse Pet-1 deletion and human PET-1 variation on amygdala fear and threat processing.
Wellman, Experimental neurology 2013 - GeneRIF: novel evidence for the role of Pet-1 in human amygdala threat processing extends literature demonstrating the influence of genetic variation in the serotonin system on emotional regulation
- The ETS oncogene family transcription factor FEV identifies serotonin-producing cells in normal and neoplastic small intestine.
Wang, Endocrine-related cancer 2010 (PubMed)- GeneRIF: FEV identifies serotonin-producing cells in normal and neoplastic small intestine.
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FEV_RAT / O70132 Protein FEV; PC12 ETS domain-containing transcription factor 1; PC12 ETS factor 1; Pet-1 from Rattus norvegicus (Rat) (see 2 papers)
FEV_MOUSE / Q8QZW2 Protein FEV; PC12 ETS domain-containing transcription factor 1; PC12 ETS factor 1; Pet-1; mPet-1 from Mus musculus (Mouse) (see 4 papers)
NP_694751 protein FEV from Mus musculus
NP_653354 protein FEV from Rattus norvegicus
61% identity, 34% coverage
- function: Functions as a transcriptional regulator. May function as a transcriptional repressor. Functions in the differentiation and the maintenance of the central serotonergic neurons. May play a role in cell growth.
- function: Functions as a transcriptional regulator. May function as a transcriptional repressor. Functions in the differentiation and the maintenance of the central serotonergic neurons. May play a role in cell growth.
disruption phenotype: Mice display heightened aggressive and anxiety- like behaviors. They also display an extended and exacerbated period of breathing instability immediately after birth which results in an increased risk of death. This is associated with loss of the differentiation of a large number of the serotonin (5-HT) neurons without major structural abnormalities of the brain. - The role of the ETS factor erg in zebrafish vasculogenesis
Ellett, Mechanisms of development 2009 - “...BAC34461; hu ERG: BC040168; zf Fli1a: AAH66571, zf Fli1b: NP_001008780; mm Fli1: NP_032052; mm FEV: NP_694751; mm ETS-1: NP_035938; zf Etsrp: AAY89037 and zf Spi1: NP_932328). Full-length sequence divergence analysis and domain-restricted alignments were performed with DNAstar Lasergene MegAlign. ETS DNA-binding domain restrictions were defined by...”
- Estradiol increases Pet-1 and serotonin transporter mRNA in the midbrain raphe nuclei of ovariectomized rats.
Rivera, Brain research 2009 - GeneRIF: We conclude that a physiologically relevant regimen of estradiol treatment in ovariectomized rats increases Pet-1 and 5-HTT mRNA levels in the midbrain raphe nuclei at a time when the anorexigenic effect of estradiol is apparent.
6vgdA / Q01543 Crystal structure of the DNA binding domain (dbd) of human fli1 and the complex of the dbd of human runx2 with core binding factor beta (cbfb), in complex with 16mer DNA cagaggatgtggcttc (see paper)
61% identity, 82% coverage
NP_001269896 ETS domain-containing protein Elk-3 isoform Elk3d from Mus musculus
78% identity, 48% coverage
XP_016872894 Friend leukemia integration 1 transcription factor isoform X1 from Homo sapiens
61% identity, 19% coverage
NP_001243224 protein C-ets-2 isoform 2 from Homo sapiens
59% identity, 13% coverage
XP_018082366 retroviral integration site protein Fli-1 homolog isoform X1 from Xenopus laevis
60% identity, 17% coverage
AST1_CAEEL / Q22355 Transcription factor ast-1; axon steering defect-1 from Caenorhabditis elegans (see 4 papers)
NP_001022326 Transcription factor ast-1 from Caenorhabditis elegans
60% identity, 21% coverage
- function: Transcription factor (PubMed:16584723, PubMed:19287374, PubMed:23788625). Probably binds to DNA sequences containing the consensus motif 5'-CGGA[AT][AG]-3' (PubMed:19287374). Positively modulates expression of dopamine pathway genes, acting as a terminal selector for differentiation of dopaminergic neurons; may act in concert with homeobox proteins ceh-40, ceh-43 and ceh-20 (PubMed:19287374, PubMed:22069471, PubMed:23788625). Required for axon navigation in some interneurons, perhaps acting in the same pathways as basement membrane protein nid-1 and unc-6/netrin (PubMed:16584723). Plays a role in the differentiation of the ventral cord pioneer neuron AVG (PubMed:16584723). Required for morphogenesis of the pharynx (PubMed:16584723).
disruption phenotype: RNAi-mediated knockdown abolishes expression of tyrosine monooxygenase cat-2 in neurons in the male-specific genital sensilla (simple sense organs) known as rays. - A passport to neurotransmitter identity.
Smidt, Genome biology 2009 - GeneRIF: Studies indicate that Loss- and gain-of-function studies defined ast-1 as necessary and sufficient for the induction and maintenance of the dopaminergic identity of these neurons.
- AST-1, a novel ETS-box transcription factor, controls axon guidance and pharynx development in C. elegans.
Schmid, Developmental biology 2006 (PubMed)- GeneRIF: AST-1 is specifically required for axon navigation in certain classes of interneurons
3zp5A / Q99581 Crystal structure of the DNA binding ets domain of the human protein fev in complex with DNA (see paper)
61% identity, 87% coverage
NP_034285 ETS domain-containing transcription factor ERF isoform b from Mus musculus
53% identity, 16% coverage
- Development of Erf-Mediated Craniosynostosis and Pharmacological Amelioration.
Vogiatzi, International journal of molecular sciences 2023 - GeneRIF: Development of Erf-Mediated Craniosynostosis and Pharmacological Amelioration.
- ETS2 repressor factor (ERF) is involved in T lymphocyte maturation acting as regulator of thymocyte lineage commitment.
Tsiomita, Journal of leukocyte biology 2022 (PubMed)- GeneRIF: ETS2 repressor factor (ERF) is involved in T lymphocyte maturation acting as regulator of thymocyte lineage commitment.
- ERF deletion rescues RAS deficiency in mouse embryonic stem cells.
Mayor-Ruiz, Genes & development 2018 - GeneRIF: deletion of Erf rescues the proliferative defects of RAS-devoid embryonic stem cells and restores their capacity to differentiate.
- ERF mutations reveal a balance of ETS factors controlling prostate oncogenesis.
Bose, Nature 2017 - GeneRIF: data provide evidence that the oncogenicity of ERG is mediated, in part, by competition with ERF and they raise the larger question of whether other gain-of-function oncogenic transcription factors might also inactivate endogenous tumour suppressors
- The Ets2 Repressor Factor (Erf) Is Required for Effective Primitive and Definitive Hematopoiesis.
Peraki, Molecular and cellular biology 2017 - GeneRIF: Results provide evidence that Erf is required for both primitive and erythromyeloid progenitor waves of hematopoietic stem cell (HSC)-independent hematopoiesis as well as for the normal function of HSCs.
- Semaphorin-7a reverses the ERF-induced inhibition of EMT in Ras-dependent mouse mammary epithelial cells.
Allegra, Molecular biology of the cell 2012 - GeneRIF: Oncogenic Ras may play a role in epithelial mesenchymal transition via the ERF and regulation of Semaphorin-7a.
- Transcriptional repressor erf determines extraembryonic ectoderm differentiation.
Papadaki, Molecular and cellular biology 2007 - GeneRIF: These data suggest that attenuation of FGF/Erk signaling and consecutive Erf nuclear localization and function is required for extraembryonic ectoderm differentiation, ectoplacental cone cavity closure, and chorioallantoic attachment.
- Ets-2 repressor factor silences extrasynaptic utrophin by N-box mediated repression in skeletal muscle.
Perkins, Molecular biology of the cell 2007 - GeneRIF: These studies suggest "repressing repressors" as a potential strategy for achieving utrophin up-regulation in Duchenne's muscular dystrophy, and they provide a model for utrophin-A regulation in muscle.
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ERF_HUMAN / P50548 ETS domain-containing transcription factor ERF; Ets2 repressor factor; PE-2 from Homo sapiens (Human) (see 4 papers)
53% identity, 16% coverage
- function: Potent transcriptional repressor that binds to the H1 element of the Ets2 promoter. May regulate other genes involved in cellular proliferation. Required for extraembryonic ectoderm differentiation, ectoplacental cone cavity closure, and chorioallantoic attachment (By similarity). May be important for regulating trophoblast stem cell differentiation (By similarity).
- Identification of Novel Substrates for cGMP Dependent Protein Kinase (PKG) through Kinase Activity Profiling to Understand Its Putative Role in Inherited Retinal Degeneration.
Roy, International journal of molecular sciences 2021 - “...Poor substrate. Peptide ID UniProt ID Peptide Sequence Description PKGI Score PKGII Score Ref. ERF_519_531 P50548 GEAGGPLTPRRVS ETS domain-containing transcription factor ERF 10 9 VASP_232_244 P50552 GAKLRKVSKQEEA Vasodilator-stimulated phosphoprotein 10 8 A (PKGI) CREB1_126_138 P16220 EILSRRPSYRKIL cAMP response element-binding protein 10 6 A, B, C (PKGI)...”
- A Rare Variant in ERF (rs144812092) Predisposes to Prostate and Bladder Cancers in an Extended Pedigree.
Cannon-Albright, Cancers 2021 - “...23 ], the canonical/reference sequence for the ERF protein was retrieved from UniProt (Uniprot ID: P50548) [ 24 ]. The variant sequence was manually modified and the two resulting sequences were submitted to the Phyre2 server [ 25 ] on intensive mode for structure prediction. Two...”
- “...multiple primary melanomas Pigment. Cell Melanoma Res. 2019 32 734 738 10.1111/pcmr.12787 31001908 24. UNIProtKB P50548 Available online: https://www.uniprot.org/uniprot/P50548#function (accessed on 13 May 2021) 25. Kelley L.A. Mezulis S. Yates C.M. Wass M.N. Sternberg M.J. The Phyre2 web portal for protein modeling, prediction and analysis Nat....”
- Reduced dosage of ERF causes complex craniosynostosis in humans and mice and links ERK1/2 signaling to regulation of osteogenesis.
Twigg, Nature genetics 2013 - “...respectively. Murine Erf mRNA sequence: NCBI reference sequence NM_010155.3. Human ETS DNA-binding proteins (Swissprot): ERF, P50548; SPI1, P17947; ETV6, P41212; ELF3; P78545; ELF1, P32519; SPDEF, O95238; ETV4, P43268; ELK1, P19419; ETS1, P14921; ETV2, O00321; ERG, P11308; GABP, Q06546. Erf ChIP-Seq data: GSE42936 (GEO). References 1 Plotnikov...”
ERF_MOUSE / P70459 ETS domain-containing transcription factor ERF from Mus musculus (Mouse) (see 2 papers)
53% identity, 16% coverage
- function: Potent transcriptional repressor that binds to the H1 element of the Ets2 promoter. May regulate other genes involved in cellular proliferation (By similarity). Required for extraembryonic ectoderm differentiation, ectoplacental cone cavity closure, and chorioallantoic attachment. May be important for regulating trophoblast stem cell differentiation.
disruption phenotype: Mice fail to undergo chorioallantoic attachment and labyrinth development and die in utero due to severe placenta defects. - The Fgf/Erf/NCoR1/2 repressive axis controls trophoblast cell fate.
Lackner, Nature communications 2023 - “...sequences used in the AlphaFold2 interaction screen were retrieved from UniProt and full-length Erf (UniProt: P70459) was used as bait for all models. See Supplementary Data 2 for details on the iPTM and PTM values of each model. Due to memory limitations of our GPU servers,...”
XP_014948195 protein C-ets-2 isoform X1 from Ovis aries
59% identity, 17% coverage
ETV3_HUMAN / P41162 ETS translocation variant 3; ETS domain transcriptional repressor PE1; PE-1; Mitogenic Ets transcriptional suppressor from Homo sapiens (Human) (see paper)
XP_006711273 ETS translocation variant 3 isoform X1 from Homo sapiens
58% identity, 16% coverage
- function: Transcriptional repressor that contribute to growth arrest during terminal macrophage differentiation by repressing target genes involved in Ras-dependent proliferation. Represses MMP1 promoter activity.
- ETV3 and ETV6 enable monocyte differentiation into dendritic cells by repressing macrophage fate commitment.
Villar, Nature immunology 2023 - GeneRIF: ETV3 and ETV6 enable monocyte differentiation into dendritic cells by repressing macrophage fate commitment.
- Indeterminate Dendritic Cell Tumor: A Report of Two New Cases Lacking the ETV3-NCOA2 Translocation and a Literature Review.
Davick, The American Journal of dermatopathology 2018 (PubMed)- GeneRIF: Case Reports/Review: indeterminate dendritic cell tumor lacking the ETV3-NCOA2 translocation.
- Frequent copy number gains at 1q21 and 1q32 are associated with overexpression of the ETS transcription factors ETV3 and ELF3 in breast cancer irrespective of molecular subtypes.
Mesquita, Breast cancer research and treatment 2013 (PubMed)- GeneRIF: Frequent copy number gains at 1q21 and 1q32 are associated with overexpression of the ETS transcription factors ETV3 and ELF3 in breast cancer irrespective of molecular subtypes.
- Differential repression of c-myc and cdc2 gene expression by ERF and PE-1/METS.
Hester, Cell cycle (Georgetown, Tex.) 2007 (PubMed)- GeneRIF: Differential repression of c-myc and cdc2 gene expression by ERF and PE-1/METS.
- Cutting edge: A transcriptional repressor and corepressor induced by the STAT3-regulated anti-inflammatory signaling pathway.
El, Journal of immunology (Baltimore, Md. : 1950) 2007 (PubMed)- GeneRIF: The ETV3 expression was strongly induced by the STAT3 pathway regulated by IL-10 but not by STAT3 signaling activated by IL-6, which cannot activate the anti-inflammatory signaling pathway.
- PE-1/METS, an antiproliferative Ets repressor factor, is induced by CREB-1/CREM-1 during macrophage differentiation.
Sawka-Verhelle, The Journal of biological chemistry 2004 (PubMed)- GeneRIF: PE-1/METS is an antiproliferative Ets repressor factor induced by CREB-1/CREM-1 during macrophage differentiation
ETV3_MOUSE / Q8R4Z4 ETS translocation variant 3; ETS domain transcriptional repressor PE1; PE-1; Mitogenic Ets transcriptional suppressor from Mus musculus (Mouse) (see 2 papers)
58% identity, 16% coverage
NP_001073683 protein C-ets-2 from Bos taurus
59% identity, 17% coverage
NP_001100577 protein C-ets-2 from Rattus norvegicus
59% identity, 17% coverage
XP_006522969 GA-binding protein alpha chain isoform X1 from Mus musculus
60% identity, 18% coverage
- Epigenetically active chromatin in neonatal iWAT reveals GABPα as a potential regulator of beige adipogenesis.
Mooli, Frontiers in endocrinology 2024 - GeneRIF: Epigenetically active chromatin in neonatal iWAT reveals GABPalpha as a potential regulator of beige adipogenesis.
- Ets transcription factor GABP controls T cell homeostasis and immunity.
Luo, Nature communications 2017 - GeneRIF: Depletion of GABPalpha impairs T-cell homeostatic survival, proliferation, and antigen-induced responses in vivo.
- GABPα Binding to Overlapping ETS and CRE DNA Motifs Is Enhanced by CREB1: Custom DNA Microarrays.
He, G3 (Bethesda, Md.) 2015 - GeneRIF: GABPalpha Binding to Overlapping ETS and CRE DNA Motifs Is Enhanced by CREB1
- GABP transcription factor (nuclear respiratory factor 2) is required for mitochondrial biogenesis.
Yang, Molecular and cellular biology 2014 - GeneRIF: conditionally deleted Gabpa, the DNA-binding component of this transcription factor complex, from embryonic fibroblasts to examine the role of Gabp in mitochondrial biogenesis, function, and gene expression
- Nuclear respiratory factor 2 regulates the expression of the same NMDA receptor subunit genes as NRF-1: both factors act by a concurrent and parallel mechanism to couple energy metabolism and synaptic transmission.
Priya, Biochimica et biophysica acta 2013 - GeneRIF: NRF-2 and NRF-1 operate in a concurrent and parallel manner in mediating the tight coupling between energy metabolism and neuronal activity at the molecular level.
- GABP transcription factor is required for development of chronic myelogenous leukemia via its control of PRKD2.
Yang, Proceedings of the National Academy of Sciences of the United States of America 2013 - GeneRIF: Loss of Gabpalpha prevented development of CML, although mice continued to generate BCR-ABL-expressing Gabpalpha-null cells for months that were serially transplantable and contributed to all lineages in secondary recipients.
- GABP controls a critical transcription regulatory module that is essential for maintenance and differentiation of hematopoietic stem/progenitor cells.
Yu, Blood 2011 - GeneRIF: Through genome-wide mapping of GABPalpha binding and transcriptomic analysis of GABPalpha-deficient HSCs, we identified Zfx and Etv6 transcription factors and prosurvival Bcl-2 family members including Bcl-2, Bcl-X(L), and Mcl-1 as direct GABP target genes.
- GABP transcription factor is required for myeloid differentiation, in part, through its control of Gfi-1 expression.
Yang, Blood 2011 - GeneRIF: Disruption of Gabpa was associated with a marked reduction in myeloid progenitor cells, and Gabpalpha null myeloid cells express reduced levels of the transcriptional repressor, Gfi-1.
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XP_015153454 protein C-ets-1 isoform X3 from Gallus gallus
59% identity, 17% coverage
Q00422 GA-binding protein alpha chain from Mus musculus
60% identity, 18% coverage
- Carcinogenic Helicobacter pylori Strains Selectively Dysregulate the In Vivo Gastric Proteome, Which May Be Associated with Stomach Cancer Progression
Noto, Molecular & cellular proteomics : MCP 2019 (secret) - 3DTF: a web server for predicting transcription factor PWMs using 3D structure-based energy calculations
Gabdoulline, Nucleic acids research 2012 - “...(UP00321/UP00398 for Rap1, Saccharomyces cerevisiae , P11938) and 0.993 (UP00013/UP00408 for Gabpa, Mus musculus , Q00422). On average, 3DTF-derived PWMs were less similar to respective Uniprobe PWMs, as in comparisons with TRANSFAC data, possibly indicating importance of several factors such as 3D modeling quality or differences...”
NP_001080391 ETS variant transcription factor 3 L homeolog from Xenopus laevis
58% identity, 15% coverage
XP_020926645 protein C-ets-2 from Sus scrofa
59% identity, 17% coverage
XP_017450940 protein C-ets-1 isoform X1 from Rattus norvegicus
59% identity, 15% coverage
- The Transcription Factor Ets1 Influences Axonal Growth via Regulation of Lcn2.
Gu, Molecular neurobiology 2024 - GeneRIF: The Transcription Factor Ets1 Influences Axonal Growth via Regulation of Lcn2.
- The histone demthylase KDM3A protects the myocardium from ischemia/reperfusion injury via promotion of ETS1 expression.
Guo, Communications biology 2022 - GeneRIF: The histone demthylase KDM3A protects the myocardium from ischemia/reperfusion injury via promotion of ETS1 expression.
- Avian erythroblastosis virus E26 oncogene homolog-1 (ETS-1) plays a role in renal microvascular pathophysiology in the Dahl salt-sensitive rat.
Feng, Kidney international 2020 - GeneRIF: Avian erythroblastosis virus E26 oncogene homolog-1 (ETS-1) plays a role in renal microvascular pathophysiology in the Dahl salt-sensitive rat.
- Transcriptomic analysis of neuregulin-1 regulated genes following ischemic stroke by computational identification of promoter binding sites: A role for the ETS-1 transcription factor.
Surles-Zeigler, PloS one 2018 - GeneRIF: Transcriptomic analysis of neuregulin-1 regulated genes following ischemic stroke by computational identification of promoter binding sites: A role for the ETS-1 transcription factor.
- Characterization of the Rat GAL2R Promoter: Positive Role of ETS-1 in Regulation of the Rat GAL2R Gene in PC12 Cells.
Yang, Molecular neurobiology 2017 (PubMed)- GeneRIF: data indicate a role for ETS-1 in the control of the GAL2R gene expression.
- miR-125a-5p Modulates Phenotypic Switch of Vascular Smooth Muscle Cells by Targeting ETS-1.
Gareri, Journal of molecular biology 2017 (PubMed)- GeneRIF: miR-125a-5p directly targets ETS-1, a transcription factor implicated in cell proliferation and migration and is crucial in PDGF-BB pathway in vascular smooth muscle cells.
- Haploinsufficiency of the Transcription Factor Ets-1 Is Renoprotective in Dahl Salt-Sensitive Rats.
Feng, Journal of the American Society of Nephrology : JASN 2017 - GeneRIF: Reduced renal expression of ETS-1 prevented hypertension-associated kidney injury in SS rats
- Transcription factor avian erythroblastosis virus E26 oncogen homolog-1 is a novel mediator of renal injury in salt-sensitive hypertension.
Feng, Hypertension (Dallas, Tex. : 1979) 2015 - GeneRIF: that salt-sensitive hypertension results in increased glomerular expression of phosphorylated ETS-1 and suggested that ETS-1 plays an important role in the pathogenesis of end-organ injury in salt-sensitive hypertension.
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XP_005226883 protein C-ets-1 isoform X1 from Bos taurus
59% identity, 17% coverage
GABPA_HUMAN / Q06546 GA-binding protein alpha chain; GABP subunit alpha; Nuclear respiratory factor 2 subunit alpha; Transcription factor E4TF1-60 from Homo sapiens (Human) (see paper)
NP_001184226 GA-binding protein alpha chain from Homo sapiens
60% identity, 18% coverage
- function: Transcription factor capable of interacting with purine rich repeats (GA repeats). Positively regulates transcription of transcriptional repressor RHIT/ZNF205 (PubMed:22306510).
function: (Microbial infection) Necessary for the expression of the Adenovirus E4 gene
subunit: Heterotetramer of two alpha and two beta subunits - GABPA inhibits tumorigenesis in clear cell renal cell carcinoma by regulating ferroptosis through ACSL4.
Wu, Scientific reports 2024 - GeneRIF: GABPA inhibits tumorigenesis in clear cell renal cell carcinoma by regulating ferroptosis through ACSL4.
- GABPA-activated TGFBR2 transcription inhibits aggressiveness but is epigenetically erased by oncometabolites in renal cell carcinoma.
Fang, Journal of experimental & clinical cancer research : CR 2022 - GeneRIF: GABPA-activated TGFBR2 transcription inhibits aggressiveness but is epigenetically erased by oncometabolites in renal cell carcinoma.
- GABPA Expression in Endometrial Carcinoma: A Prognostic Marker.
Ma, Disease markers 2021 - GeneRIF: GABPA Expression in Endometrial Carcinoma: A Prognostic Marker.
- TERT promoter mutations and GABP transcription factors in carcinogenesis: More foes than friends.
Yuan, Cancer letters 2020 (PubMed)- GeneRIF: TERT promoter mutations and GABP transcription factors in carcinogenesis: More foes than friends.
- GABPA inhibits invasion/metastasis in papillary thyroid carcinoma by regulating DICER1 expression.
Yuan, Oncogene 2019 (PubMed)- GeneRIF: a positive correlation between GABPA and DICER1 expression was seen in multiple types of malignancies. Taken together, despite its stimulatory effect on the mutant TERT promoter and telomerase activation, GABPA may itself act as a tumor suppressor rather than an oncogenic factor to inhibit invasion/metastasis in thyroid carcinomas.
- Identification of GA-Binding Protein Transcription Factor Alpha Subunit (GABPA) as a Novel Bookmarking Factor.
Goto, International journal of molecular sciences 2019 - GeneRIF: Therefore, we proposed that GABPA cooperates with the states of histone acetylation to act as a novel bookmarking factor which, may negatively regulate transcription during the early G1 phase.
- Golgi stress-induced transcriptional changes mediated by MAPK signaling and three ETS transcription factors regulate MCL1 splicing.
Baumann, Molecular biology of the cell 2018 - GeneRIF: enhanced ETS factor activity and the transcription of ETS family target genes related to spliceosome function and cell death induction via alternate MCL1 splicing, is reported.
- Expression of the human TIMM23 and TIMM23B genes is regulated by the GABP transcription factor.
Prieto-Ruiz, Biochimica et biophysica acta. Gene regulatory mechanisms 2018 (PubMed)- GeneRIF: Data indicate the essential role of the GABP transcription factor in activating translocase of inner mitochondrial membrane 23 TIMM23 and TIMM23B expression.
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- Quantitative proteomic analyses of CD4+ and CD8+ T cells reveal differentially expressed proteins in multiple sclerosis patients and healthy controls.
Berge, Clinical proteomics 2019 - “...dipeptidyl peptidase 1 light chain CTSC 0.006992 0.36305 20.5409 0.54754 20.90395 0.10359 19.9 7 0.81 Q06546 GA-binding protein alpha chain GABPA 0.006996 0.2074 21.3763 0.1983 21.1689 0.20734 28 8 0.8 P21399 Cytoplasmic aconitate hydratase ACO1 0.008051 0.1699 21.4757 0.14153 21.3058 0.20875 20.4 11 0.82 Q9H400 Lck-interacting...”
- Reduced dosage of ERF causes complex craniosynostosis in humans and mice and links ERK1/2 signaling to regulation of osteogenesis.
Twigg, Nature genetics 2013 - “...ELF1, P32519; SPDEF, O95238; ETV4, P43268; ELK1, P19419; ETS1, P14921; ETV2, O00321; ERG, P11308; GABP, Q06546. Erf ChIP-Seq data: GSE42936 (GEO). References 1 Plotnikov A Zehorai E Procaccia S Seger R The MAPK cascades: signaling components, nuclear roles and mechanisms of nuclear translocation Biochim. Biophys. Acta...”
P15037 Protein C-ets-2 from Mus musculus
NP_035939 protein C-ets-2 from Mus musculus
59% identity, 17% coverage
- Proteins with two SUMO-like domains in chromatin-associated complexes: the RENi (Rad60-Esc2-NIP45) family
Novatchkova, BMC bioinformatics 2005 - “...Academy of Science, Boehringer Ingelheim, by the Fonds zur Frderung der wissenschaftlichen Forschung sterreichs (FWF P15037) and by the Austrian Gen-AU bioinformatics integration network sponsored by BM-BWK. Jentsch S Pyrowolakis G Ubiquitin and its kin: how close are the family ties? Trends Cell Biol 2000 10...”
- Refinement and prediction of protein prenylation motifs
Maurer-Stroh, Genome biology 2005 - “...has been partly funded by the Fonds zur Frderung der wissenschaftlichen Forschung sterreichs (FWF grant P15037), the Austrian National Bank (sterreichische Nationalbank) and by the bioinformatics contract study 2002-2004 for Bundesministerium fuer Wirtschaft und Arbeit. Casey PJ Seabra MC Protein prenyltransferases. J Biol Chem 1996 271...”
- Protein prenyltransferases
Maurer-Stroh, Genome biology 2003 - “...has been partly funded by the Fonds zur Frderung der wissenschaftlichen Forschung sterreichs (FWF grant P15037) and by the Austrian National Bank (OeNB). Casey PJ Seabra MC Protein prenyltransferases. J Biol Chem 1996 271 5289 5292 A short minireview describing protein prenyltransferases, written before the structure...”
- ETS2 alleviates acute-on-chronic liver failure by suppressing excessive inflammation.
He, Journal of medical virology 2023 (PubMed)- GeneRIF: ETS2 alleviates acute-on-chronic liver failure by suppressing excessive inflammation.
- ETS2 overexpression ameliorates cartilage injury in osteoarthritis by the ETS2/miR-155/STAT1/DNMT1 feedback loop pathway.
Chen, Biochimica et biophysica acta. Gene regulatory mechanisms 2023 (PubMed)- GeneRIF: ETS2 overexpression ameliorates cartilage injury in osteoarthritis by the ETS2/miR-155/STAT1/DNMT1 feedback loop pathway.
- Ets-2 deletion in myeloid cells attenuates IL-1α-mediated inflammatory disease caused by a Ptpn6 point mutation.
Tartey, Cellular & molecular immunology 2021 - GeneRIF: Ets-2 deletion in myeloid cells attenuates IL-1alpha-mediated inflammatory disease caused by a Ptpn6 point mutation.
- Cooperative Binding of ETS2 and NFAT Links Erk1/2 and Calcineurin Signaling in the Pathogenesis of Cardiac Hypertrophy.
Luo, Circulation 2021 - GeneRIF: Cooperative Binding of ETS2 and NFAT Links Erk1/2 and Calcineurin Signaling in the Pathogenesis of Cardiac Hypertrophy.
- Protein C-ets-2 epigenetically suppresses TLRs-induced interleukin 6 production in macrophages.
Zhao, Biochemical and biophysical research communications 2020 (PubMed)- GeneRIF: Protein C-ets-2 epigenetically suppresses TLRs-induced interleukin 6 production in macrophages.
- EGF suppresses the expression of miR-124a in pancreatic β cell lines via ETS2 activation through the MEK and PI3K signaling pathways.
Yang, International journal of biological sciences 2019 - GeneRIF: ETS2 is identified as a novel regulator of insulin production and a potential therapeutic target for diabetes mellitus treatment.
- Ets2 suppresses inflammatory cytokines through MAPK/NF-κB signaling and directly binds to the IL-6 promoter in macrophages.
Ma, Aging 2019 - GeneRIF: Ets2 suppresses inflammatory cytokines through MAPK/NF-kappaB signaling and directly binds to the IL-6 promoter in macrophages.
- Suppression of Fgf2 by ETS2 repressor factor (ERF) is required for chorionic trophoblast differentiation.
Vorgia, Molecular reproduction and development 2017 (PubMed)- GeneRIF: The differentiation of ERF-overexpressing trophoblast stem cell lines also suggests that ERF may have an FGF2-independent effect during the commitment towards syncytiotrophoblasts.
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ETS2_HUMAN / P15036 Protein C-ets-2 from Homo sapiens (Human) (see 2 papers)
59% identity, 17% coverage
- function: Transcription factor activating transcription. Binds specifically the DNA GGAA/T core motif (Ets-binding site or EBS) in gene promoters and stimulates transcription.
- The role of HR-HPV integration in the progression of premalignant lesions into different cancer types.
Catalán-Castorena, Heliyon 2024 - “...( WGS ) E1, E4 and E5 Introns, exons, the promoter region RAD51B ((O15315) ETS2 (P15036) PDL1 (Q9NZQ7) NR4A2 (P43354) TP63 (O88898) KLF5 (Q13887) BARX2 (Q9UMQ3) [ 104 ] 7 head and neck cancer cell lines (HPV 16 and 18) Whole-genome sequencing ( WGS ) *Does...”
- Comprehensive Statistical and Bioinformatics Analysis in the Deciphering of Putative Mechanisms by Which Lipid-Associated GWAS Loci Contribute to Coronary Artery Disease.
Lazarenko, Biomedicines 2022 - “...predicting that five transcription activators such as E2F2 (UniProtKB-Q14209), ETS1 (UniProtKB-P14921), ETS2 (UniProtKB-P15036) and HNF4BA (P15036) and HNF4BA (P15036), and HNF4BA (UniProt35) have an affinity for binding to a DNA motif in the presence of the rs3136441-C allele of the F2 gene. ETS1 is a transcription...”
- Acetylation Increases EWS-FLI1 DNA Binding and Transcriptional Activity.
Schlottmann, Frontiers in oncology 2012 - “...of different ets family members at relevant lysine positions. Protein sequences of ETS1 (P14921), ETS2 (P15036), ETV6 (P41212), ETV7 (Q9Y603), SPIB (Q01892), SPI1 (P17947), ETV1 (P50549), ETV5 (P41161), ETV4 (P43268), ERG (P11308), FLI1 (Q01543), FEV (Q99581), and ETV2 (O00321) were aligned using UniProt, to reveal conservation...”
NP_001137292 protein C-ets-1 isoform 1 from Homo sapiens
59% identity, 17% coverage
- ETS1 regulates NDRG1 to promote the proliferation, migration, and invasion of OSCC.
Sheng, Oral diseases 2024 (PubMed)- GeneRIF: ETS1 regulates NDRG1 to promote the proliferation, migration, and invasion of OSCC.
- ERK/MAPK Signalling Pathway Regulates MMP2 through ETS1 in Renal Clear Cell Carcinoma.
Chen, Current molecular medicine 2024 (PubMed)- GeneRIF: ERK/MAPK Signalling Pathway Regulates MMP2 through ETS1 in Renal Clear Cell Carcinoma.
- Allele-specific effect of various dietary fatty acids and ETS1 transcription factor on SCD1 expression.
Tibori, Scientific reports 2024 - GeneRIF: Allele-specific effect of various dietary fatty acids and ETS1 transcription factor on SCD1 expression.
- Downregulation of circular RNA ETS1 promotes SLE activity and inhibits Treg cell differentiation through miR-1205/FoxP3 molecular axis.
Zou, International immunopharmacology 2024 (PubMed)- GeneRIF: Downregulation of circular RNA ETS1 promotes SLE activity and inhibits Treg cell differentiation through miR-1205/FoxP3 molecular axis.
- HMGA1 sensitizes esophageal squamous cell carcinoma to mTOR inhibitors through the ETS1-FKBP12 axis.
Guo, International journal of biological sciences 2024 - GeneRIF: HMGA1 sensitizes esophageal squamous cell carcinoma to mTOR inhibitors through the ETS1-FKBP12 axis.
- Mechanoresponsive ETS1 causes endothelial dysfunction and arterialization in varicose veins via NOTCH4/DLL4 signaling.
Sreelakshmi, European journal of cell biology 2024 (PubMed)- GeneRIF: Mechanoresponsive ETS1 causes endothelial dysfunction and arterialization in varicose veins via NOTCH4/DLL4 signaling.
- ETS1 and RBPJ transcriptionally regulate METTL14 to suppress TGF-β1-induced epithelial-mesenchymal transition in human bronchial epithelial cells.
Chen, Biochimica et biophysica acta. Molecular basis of disease 2024 (PubMed)- GeneRIF: ETS1 and RBPJ transcriptionally regulate METTL14 to suppress TGF-beta1-induced epithelial-mesenchymal transition in human bronchial epithelial cells.
- Circ-PITX1 promotes non-small-cell lung cancer progression through regulating ETS1 expression via miR-615-5p.
Guo, Thoracic cancer 2024 - GeneRIF: Circ-PITX1 promotes non-small-cell lung cancer progression through regulating ETS1 expression via miR-615-5p.
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F6Q5G9 ETS variant transcription factor 2 from Equus caballus
56% identity, 25% coverage
NP_001081082 protein c-ets-1-A from Xenopus laevis
59% identity, 18% coverage
XP_060260246 protein C-ets-1 isoform X3 from Ovis aries
59% identity, 18% coverage
XP_012821643 protein C-ets-1 isoform X1 from Xenopus tropicalis
59% identity, 19% coverage
ETS1_MOUSE / P27577 Protein C-ets-1; p54 from Mus musculus (Mouse) (see 6 papers)
NP_035938 protein C-ets-1 isoform 1 from Mus musculus
59% identity, 18% coverage
- function: Transcription factor (PubMed:15994560). Directly controls the expression of cytokine and chemokine genes in a wide variety of different cellular contexts (By similarity). May control the differentiation, survival and proliferation of lymphoid cells (By similarity). May also regulate angiogenesis through regulation of expression of genes controlling endothelial cell migration and invasion (By similarity).
subunit: Binds DNA as a homodimer; homodimerization is required for transcription activation (PubMed:15591056). Interacts with MAF and MAFB (PubMed:10790365, PubMed:9566892). Interacts with PAX5; the interaction alters DNA-binding properties (PubMed:11779502). Interacts with DAXX. Interacts with UBE2I. Interacts with SP100; the interaction is direct and modulates ETS1 transcriptional activity (By similarity). - The role of the ETS factor erg in zebrafish vasculogenesis
Ellett, Mechanisms of development 2009 - “...BC040168; zf Fli1a: AAH66571, zf Fli1b: NP_001008780; mm Fli1: NP_032052; mm FEV: NP_694751; mm ETS-1: NP_035938; zf Etsrp: AAY89037 and zf Spi1: NP_932328). Full-length sequence divergence analysis and domain-restricted alignments were performed with DNAstar Lasergene MegAlign. ETS DNA-binding domain restrictions were defined by comparative alignment to...”
- Comparison of predicted and actual consequences of missense mutations
Miosge, Proceedings of the National Academy of Sciences of the United States of America 2015 - “...No No No No No No Q8K4J0 Q8C147 Q8C147 P27577 Q8R081 Q60769 Q60611 P35991 P97313 P16872 Q8BTF7 Q8C863 Q9JKD8 P97313 Q4VBF6 Q8C147 Q8C147 P15919 P01590 Q9Z1S3...”
- Cardiogenol C can induce Mouse Hair Bulge Progenitor Cells to Transdifferentiate into Cardiomyocyte-like Cells.
Yau, Proteome science 2011 - “...cross-links; highly expressed in heart, lung, kidney, eye, ovary, and placenta Protein C-ets-1 55/4.8 50.2/5.0 P27577 1.7 Transcription factor. Binds to DAXX. Interacts with UBE2I. Essential for normal coronary and myocardial development in chicken embryos Salt-inducible kinase (SIK1) 81/6.4 85.0/6.4 Q60670 3.8 Transient role during the...”
P41156 Protein C-ets-1 from Rattus norvegicus
59% identity, 18% coverage
- Gene analogue finder: a GRID solution for finding functionally analogous gene products
Tulipano, BMC bioinformatics 2007 - “...sapiens 50 38.0 14 BI1_HUMAN P55061 9345,2 34 UPF0005 Homo sapiens 155 19.4 15 Ets1 P41156 9302,5 42 Ets Rattus norvegicus 53 28.3 16 API5_CHICK Q5ZMW3 9245,1 34 API5 Gallus gallus 107 23.4 17 Bcl2l2 P70345 9232,3 30 Bcl-2 Mus musculus 235 37.0 18 Bnip1 Q8VHI8...”
- AntiJen: a quantitative immunology database integrating functional, thermodynamic, kinetic, biophysical, and cellular data.
Toseland, Immunome research 2005 - “...peptide sequence most closely matches (in the case of YTSDYFISY : C-ests-1 (p54), SWISS-PROT code P41156 ). The description of the antigen is, wherever possible, obtained directly from the literature. AntiJen is also linked to PUBMED. This allows us to record the original citation associated with...”
ETS1_HUMAN / P14921 Protein C-ets-1; p54 from Homo sapiens (Human) (see 8 papers)
59% identity, 18% coverage
- function: Transcription factor (PubMed:10698492, PubMed:11909962). Directly controls the expression of cytokine and chemokine genes in a wide variety of different cellular contexts (PubMed:20378371). May control the differentiation, survival and proliferation of lymphoid cells (PubMed:20378371). May also regulate angiogenesis through regulation of expression of genes controlling endothelial cell migration and invasion (PubMed:15247905, PubMed:15592518).
function: [Isoform Ets-1 p27]: Acts as a dominant-negative for isoform c-ETS-1A.
subunit: Binds DNA as a homodimer; homodimerization is required for transcription activation (PubMed:18566588). Interacts with MAF and MAFB (By similarity). Interacts with PAX5; the interaction alters DNA- binding properties (By similarity). Interacts with DAXX (PubMed:10698492). Interacts with UBE2I (PubMed:9333025). Interacts with SP100; the interaction is direct and modulates ETS1 transcriptional activity (PubMed:11909962, PubMed:15247905). - In Silico Modeling of Fabry Disease Pathophysiology for the Identification of Early Cellular Damage Biomarker Candidates
Gervas-Arruga, International journal of molecular sciences 2024 - “...75 NV SPP1 P10451 YES NO 75 N ANK3 Q12955 YES NO 74 N ETS1 P14921 YES NO 73 N PKN2 Q16513 YES NO 72 N YWHAQ P27348 YES NO 72 N HIPK2 Q9H2X6 YES NO 71 NV ANK2 Q01484 YES NO 71 NV DCC P43146...”
- Bioinformatic characterization of ENPEP, the gene encoding a potential cofactor for SARS-CoV-2 infection.
Arppo, PloS one 2024 - “...0.7812 3383 P27105 Erythrocyte band 7 integral membrane protein cytoskeletal protein Testis ETS1 0.7682 3488 P14921 Protein C-ets-1 winged helix/forkhead transcription factor Testis PDLIM5 0.7569 17468 Q96HC4 PDZ and LIM domain protein 5 actin or actin-binding cytoskeletal protein Testis IFI16 0.7557 5395 Q16666 Gamma-interferon-inducible protein 16...”
- Protein disorder and autoinhibition: The role of multivalency and effective concentration.
Fenton, Current opinion in structural biology 2023 - Accurate, high-coverage assignment of in vivo protein kinases to phosphosites from in vitro phosphoproteomic specificity data
Invergo, PLoS computational biology 2022 - “...example, sites S252, S257, S282, and S285 on transcription factor C-ets-1 ( ETS1 ; Uniprot: P14921 / ETS1_HUMAN) are all annotated to the most commonly studied subunit, , whereas IV-KAPhE indicates that the evidence supports the least commonly studied subunit, [ 29 ], as the causal...”
- Alendronate-induced Perturbation of the Bone Proteome and Microenvironmental Pathophysiology.
Kim, International journal of medical sciences 2021 - “...enzyme 1.2145 0.1359 0.0149 0.0103 Q9ULH7 MRTFB Myocardin-related transcription factor B 1.1752 0.1301 0.0877 0.0397 P14921 ETS1 Protein C-ets-1 1.1566 0.1653 0.0497 0.0319 Q9H0V9 LMAN2L VIP36-like protein 1.1446 0.013 0.1852 0.0136 Q15427 SF3B4 Splicing factor 3B subunit 4 1.0902 0.3234 0.0296 0.0487 Q9H223 EHD4 EH domain-containing...”
- Identification and host response interaction study of SARS-CoV-2 encoded miRNA-like sequences: an in silico approach.
Roy, Computers in biology and medicine 2021 - “...regulator Bcl-2 Tumorigenesis CTNNB1 ( P35222 ) Catenin beta-1 Tumorigenesis, Endocrine homeostasis Neuroinvasion ETS1 ( P14921 ) ETS proto-oncogene 1, transcription factor Tumorigenesis, Endocrine homeostasis AGUGUGCUUUUCCAUCAUGACA SARS-CoV-2-miR-077 IGF2 ( A0A2R8Y747 ) Insulin-like growth factor II Tumorigenesis UUGUUGUUGGCCUUUACCAGAC SARS-CoV-2-miR-084 CRKL ( P46109 ) CRK like proto-oncogene, adaptor...”
- Feeding of yeast cell wall extracts during a necrotic enteritis challenge enhances cell growth, survival and immune signaling in the jejunum of broiler chickens.
Johnson, Poultry science 2020 - “...S283 1.071 0.001 1.051 0.035 1.024 0.041 P12931 SRC S17 S17 1.032 0.037 1.030 0.016 P14921 ETS1 T38 T82 1.031 0.013 1.047 0 P31749 AKT1 T308 T74 1.045 0.020 1.054 0.008 P37231 PPARG S112 S82 1.042 0.032 1.084 0 P49840 GSK3A S278 S185 1.080 0.004 1.074...”
- System, Method and Software for Calculation of a Cannabis Drug Efficiency Index for the Reduction of Inflammation.
Borisov, International journal of molecular sciences 2020 - “...EPHA2 Ephrin type-A receptor 2 UniProtKB: P01588 EPO Erythropoietin UniProtKB: P03372 ESR1 Estrogen receptor UniProtKB: P14921 ETS1 Protein C-ets-1 UniProtKB: P15090 FABP4 Fatty acid-binding protein, adipocyte UniProtKB: O15360 FANCA Fanconi anemia group A protein UniProtKB: Q9BXW9 FANCD2 Fanconi anemia group D2 protein UniProtKB: P30273 FCER1G High...”
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P10157 Protein C-ets-2 from Gallus gallus
59% identity, 17% coverage
4bqaA / P15036 Crystal structure of the ets domain of human ets2 in complex with DNA (see paper)
58% identity, 63% coverage
A8K725 cDNA FLJ75737, highly similar to Homo sapiens v-ets erythroblastosis virus E26 oncogene homolog 1 (avian) (ETS1), mRNA from Homo sapiens
58% identity, 18% coverage
- Antitumor Effects and the Potential Mechanism of 10-HDA against SU-DHL-2 Cells.
Tian, Pharmaceuticals (Basel, Switzerland) 2024 - “...A0A3B3ITW1, B2R7U4, P02751, A0A024R728, Q92466, P63218, Q6TKP8, A0A2 0SFF5 B3KT21, A0A0U1RQC9, Q9HAV0, U6FVB0, X5D945, P11802, A8K725, P33552, A0A024R8H5, Q5T178, A0A024QYW7, B3KNJ3 Small-cell lung cancer 0.0147 0.5780 P02751, Q92466 A0A0U1RQC9, P11802, P33552, A0A024R8H5, Q5T178 Staphylococcus aureus infection 0.0161 0.5780 C9JC84 A0A0F7G8J1, B2R7F8 Pyrimidine metabolism 0.0210 0.6627 P36954...”
O00321 ETS translocation variant 2 from Homo sapiens
51% identity, 25% coverage
- Crystal Structure of FOXC2 in Complex with DNA Target.
Li, ACS omega 2019 - “...ETV2 have been identified. 40 We built a composite model of FOXC2 and ETV2 (UniProtKB O00321) DNA-binding domains bound to the FOXETS motif in the Mef2c enhancer sequence, based on the FOXO1 and ETS cocrystal structure (RCSB 4LG0). 41 We generated the FOXC2ETV2 complex model using...”
- Reduced dosage of ERF causes complex craniosynostosis in humans and mice and links ERK1/2 signaling to regulation of osteogenesis.
Twigg, Nature genetics 2013 - “...ETV6, P41212; ELF3; P78545; ELF1, P32519; SPDEF, O95238; ETV4, P43268; ELK1, P19419; ETS1, P14921; ETV2, O00321; ERG, P11308; GABP, Q06546. Erf ChIP-Seq data: GSE42936 (GEO). References 1 Plotnikov A Zehorai E Procaccia S Seger R The MAPK cascades: signaling components, nuclear roles and mechanisms of nuclear...”
- Acetylation Increases EWS-FLI1 DNA Binding and Transcriptional Activity.
Schlottmann, Frontiers in oncology 2012 - “...(P17947), ETV1 (P50549), ETV5 (P41161), ETV4 (P43268), ERG (P11308), FLI1 (Q01543), FEV (Q99581), and ETV2 (O00321) were aligned using UniProt, to reveal conservation of Lysine positions K240, K252, K380, and K397. (C,D) Acetylation mutants were in vitro acetylated by CBP (C) or PCAF (D) . (E)...”
- Interplay among Etsrp/ER71, Scl, and Alk8 signaling controls endothelial and myeloid cell formation.
Sumanas, Blood 2008
1awcA / Q00422 Mouse gabp alpha/beta domain bound to DNA (see paper)
60% identity, 75% coverage
6da1B / P27577 Ets1 in complex with synthetic srr mimic (see paper)
58% identity, 60% coverage
XP_011524926 ETS translocation variant 2 isoform X3 from Homo sapiens
50% identity, 35% coverage
- SOX17/ETV2 improves the direct reprogramming of adult fibroblasts to endothelial cells.
Grath, Cell reports methods 2024 - GeneRIF: SOX17/ETV2 improves the direct reprogramming of adult fibroblasts to endothelial cells.
- BCL6B-dependent suppression of ETV2 hampers endothelial cell differentiation.
Li, Stem cell research & therapy 2024 - GeneRIF: BCL6B-dependent suppression of ETV2 hampers endothelial cell differentiation.
- A 3-Gene Random Forest Model to Diagnose Non-obstructive Azoospermia Based on Transcription Factor-Related Henes.
Zhou, Reproductive sciences (Thousand Oaks, Calif.) 2023 (PubMed)- GeneRIF: A 3-Gene Random Forest Model to Diagnose Non-obstructive Azoospermia Based on Transcription Factor-Related Henes.
- ETV2/ER71, the key factor leading the paths to vascular regeneration and angiogenic reprogramming.
Kim, Stem cell research & therapy 2023 - GeneRIF: ETV2/ER71, the key factor leading the paths to vascular regeneration and angiogenic reprogramming.
- ETV2 primes hematoendothelial gene enhancers prior to hematoendothelial fate commitment.
Steimle, Cell reports 2023 - GeneRIF: ETV2 primes hematoendothelial gene enhancers prior to hematoendothelial fate commitment.
- ETV2 regulates PARP-1 binding protein to induce ER stress-mediated death in tuberin-deficient cells.
Shrestha, Life science alliance 2022 - GeneRIF: ETV2 regulates PARP-1 binding protein to induce ER stress-mediated death in tuberin-deficient cells.
- ETV2 promotes osteogenic differentiation of human dental pulp stem cells through the ERK/MAPK and PI3K-Akt signaling pathways.
Li, Stem cell research & therapy 2022 - GeneRIF: ETV2 promotes osteogenic differentiation of human dental pulp stem cells through the ERK/MAPK and PI3K-Akt signaling pathways.
- FGF primes angioblast formation by inducing ETV2 and LMO2 via FGFR1/BRAF/MEK/ERK.
Chen, Cellular and molecular life sciences : CMLS 2021 - GeneRIF: FGF primes angioblast formation by inducing ETV2 and LMO2 via FGFR1/BRAF/MEK/ERK.
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XP_020952864 ETS translocation variant 2 from Sus scrofa
51% identity, 25% coverage
ELG_DROME / Q04688 DNA-binding protein Ets97D; D-elg from Drosophila melanogaster (Fruit fly) (see paper)
NP_524523 Ets at 97D, isoform A from Drosophila melanogaster
55% identity, 17% coverage
NP_031985 ETS translocation variant 2 from Mus musculus
55% identity, 24% coverage
- Overexpression of ETV2 in BMSCs promoted wound healing in cutaneous wound mice by triggering the differentiation of BMSCs into endothelial cells and modulating the transformation of M1 phenotype macrophages to M2 phenotype macrophages.
Shang, Tissue & cell 2024 (PubMed)- GeneRIF: Overexpression of ETV2 in BMSCs promoted wound healing in cutaneous wound mice by triggering the differentiation of BMSCs into endothelial cells and modulating the transformation of M1 phenotype macrophages to M2 phenotype macrophages.
- ETV2 Upregulation Marks the Specification of Early Cardiomyocytes and Endothelial Cells During Co-differentiation.
Cao, Stem cells (Dayton, Ohio) 2023 - GeneRIF: ETV2 Upregulation Marks the Specification of Early Cardiomyocytes and Endothelial Cells During Co-differentiation.
- Etv2 regulates enhancer chromatin status to initiate Shh expression in the limb bud.
Koyano-Nakagawa, Nature communications 2022 - GeneRIF: Etv2 regulates enhancer chromatin status to initiate Shh expression in the limb bud.
- ETV2 (Ets Variant Transcription Factor 2)-Rhoj Cascade Regulates Endothelial Progenitor Cell Migration During Embryogenesis.
Singh, Arteriosclerosis, thrombosis, and vascular biology 2020 (PubMed)- GeneRIF: ETV2 (Ets Variant Transcription Factor 2)-Rhoj Cascade Regulates Endothelial Progenitor Cell Migration During Embryogenesis.
- Etv2 transcriptionally regulates Yes1 and promotes cell proliferation during embryogenesis.
Singh, Scientific reports 2019 - GeneRIF: Etv2 transcriptionally regulates Yes1 and promotes cell proliferation during embryogenesis.
- ETV-2 activated proliferation of endothelial cells and attenuated acute hindlimb ischemia in mice.
Van, In vitro cellular & developmental biology. Animal 2017 (PubMed)- GeneRIF: This study aimed to evaluate the effects of the E-twenty six (ETS) factor Ets variant 2 (ETV2) gene expression in angiogenesis and the effect of ETV2 gene therapy in a mouse model of hindlimb ischemia.
- ETV2/ER71 regulates hematopoietic regeneration by promoting hematopoietic stem cell proliferation.
Xu, The Journal of experimental medicine 2017 - GeneRIF: These findings demonstrate that Etv2 is an important regulator of hematopoietic regeneration.
- Embryonic Stem Cell Differentiation to Functional Arterial Endothelial Cells through Sequential Activation of ETV2 and NOTCH1 Signaling by HIF1α.
Tsang, Stem cell reports 2017 - GeneRIF: HIF1alpha activation of Etv2 in embryonic stem cells followed by NOTCH1 signaling is required for the generation arterial endothelial cells that are capable of arteriogenesis and revascularization of ischemic tissue.
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E74EF_DROVI / Q7M3M6 Ecdysone-induced protein 74EF; ETS-related protein E74A from Drosophila virilis (Fruit fly) (see paper)
51% identity, 10% coverage
- function: Probably acts as a transcription factor during metamorphosis.
E74EA_DROME / P20105 Ecdysone-induced protein 74EF isoform A; ETS-related protein E74A from Drosophila melanogaster (Fruit fly) (see paper)
51% identity, 10% coverage
PNT_DROME / P51023 ETS-like protein pointed from Drosophila melanogaster (Fruit fly) (see 10 papers)
NP_524461 pointed, isoform B from Drosophila melanogaster
60% identity, 11% coverage
- function: ETS transcription factor with a prominent role during development of the eye and the nervous system (PubMed:23757412, PubMed:28245922, PubMed:8033205, PubMed:8223245). Required for glial- neuronal cell interactions at the ventral midline which are necessary for the proper elaboration of commissures in the embryonic CNS (PubMed:8223245).
function: [Isoform P2]: Required for normal EGFR-induced photoreceptor development probably as a downstream effector of Ras85D (PubMed:23757412, PubMed:8033205). In larval eye imaginal disks, activated by MAPK phosphorylation following EGFR activation, induces transcription of isoform P1 which in turn activates transcription of target genes essential for photoreceptor development (PubMed:23757412)
function: [Isoform P1]: Required for normal EGFR-induced photoreceptor development (PubMed:23757412). Following transcriptional activation by isoform P2, acts as a constitutive activator of transcription, leading to induction of target genes essential for photoreceptor development (PubMed:23757412, PubMed:8033205). In larval brains, involved in the maintenance of type II neuroblast self-renewal and identity together with brat, btd and pros; prevents intermediate neuronal progenitor (INP) dedifferentiation by regulating the expression of erm probably via Notch signaling; suppresses Ase expression in type II neuroblasts and promotes the generation of intermediate neuronal progenitors (PubMed:22143802, PubMed:27151950, PubMed:27510969, PubMed:28245922, PubMed:28899667).
disruption phenotype: Embryonic lethal showing loss of photoreceptors (PubMed:23757412, PubMed:8033205, PubMed:8223245). In larvae, RNAi- mediated knockdown results in a transformation of type II neuroblasts into type I neuroblasts, elimination of intermediary neuronal progenitors (INP) and generation of extra type II neuroblasts; in the ventral nerve cord, results in increased numbers of type I neuroblasts (PubMed:27151950, PubMed:27510969, PubMed:28899667). Simultaneous RNAi- mediated knockdown of the zinc-finger transcriptional repressor erm, the transcriptional repressor E(spl)mdelta-HLH or the transcriptional repressor dpn restore normal neuroblast numbers (PubMed:28899667). Simultaneous RNAi-mediated knockdown of N partially restores normal neuroblast numbers and inhibits ectopic erm expression in the central brain and ventral nerve cord (PubMed:27151950). - Integrative genomic analyses reveal putative cell type-specific targets of the Drosophila ets transcription factor Pointed.
Bollepogu, BMC genomics 2024 - GeneRIF: Integrative genomic analyses reveal putative cell type-specific targets of the Drosophila ets transcription factor Pointed.
- The Ets protein Pointed P1 represses Asense expression in type II neuroblasts by activating Tailless.
Chen, PLoS genetics 2022 - GeneRIF: The Ets protein Pointed P1 represses Asense expression in type II neuroblasts by activating Tailless.
- DamID transcriptional profiling identifies the Snail/Scratch transcription factor Kahuli as an Alk target in the Drosophila visceral mesoderm.
Mendoza-Garcia, Development (Cambridge, England) 2021 - GeneRIF: DamID transcriptional profiling identifies the Snail/Scratch transcription factor Kahuli as an Alk target in the Drosophila visceral mesoderm.
- The ETS-transcription factor Pointed is sufficient to regulate the posterior fate of the follicular epithelium.
Stevens, Development (Cambridge, England) 2020 - GeneRIF: The ETS-transcription factor Pointed is sufficient to regulate the posterior fate of the follicular epithelium.
- A context-dependent bifurcation in the Pointed transcriptional effector network contributes specificity and robustness to retinal cell fate acquisition.
Wu, PLoS genetics 2020 - GeneRIF: A context-dependent bifurcation in the Pointed transcriptional effector network contributes specificity and robustness to retinal cell fate acquisition.
- Longevity is determined by ETS transcription factors in multiple tissues and diverse species.
Dobson, PLoS genetics 2019 - GeneRIF: Pnt is important for adults facing nutritional variation or stress.
- Collaborative repressive action of the antagonistic ETS transcription factors Pointed and Yan fine-tunes gene expression to confer robustness in Drosophila.
Webber, Development (Cambridge, England) 2018 - GeneRIF: a new layer of regulation whereby Yan and Pointed co-occupy regulatory elements to repress gene expression in a coordinated manner, with Pointed being unexpectedly required for the genome-wide occupancy of both Yan and the co-repressor Groucho.
- A Hox complex activates and potentiates the Epidermal Growth Factor signaling pathway to specify Drosophila oenocytes.
Wang, PLoS genetics 2017 - GeneRIF: Both PntP1 and PntP2 are required for oenocyte specification. Since PntP1 is a downstream effector of EGF signaling, these findings provide insight into how a Hox factor can both trigger and potentiate the EGF signal to promote an essential cell fate along the body plan.
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7jsaJ / P50548 Crystal structure of the DNA binding domain of human transcription factor erf in the reduced form, in complex with double-stranded DNA accggaagtg (see paper)
56% identity, 90% coverage
NP_001037444 transcription factor E74 from Bombyx mori
Q1KLS0 Transcription factor E74 isoform A from Bombyx mori
51% identity, 17% coverage
LOC109418949 ecdysone-induced protein 74EF from Aedes albopictus
49% identity, 11% coverage
E74EB_DROME / P11536 Ecdysone-induced protein 74EF isoform B; ETS-related protein E74B from Drosophila melanogaster (Fruit fly) (see paper)
NP_001014590 Ecdysone-induced protein 74EF, isoform D from Drosophila melanogaster
51% identity, 10% coverage
- Eip74EF is a dominant modifier for ALS-FTD-linked VCPR152H phenotypes in the Drosophila eye model.
Chalmers, BMC research notes 2023 - GeneRIF: Eip74EF is a dominant modifier for ALS-FTD-linked VCP[R152H] phenotypes in the Drosophila eye model.
- A putative novel role for Eip74EF in male reproduction in promoting sperm elongation at the cost of male fecundity.
Chebbo, Journal of experimental zoology. Part B, Molecular and developmental evolution 2021 (PubMed)- GeneRIF: A putative novel role for Eip74EF in male reproduction in promoting sperm elongation at the cost of male fecundity.
- The Drosophila melanogaster Eip74EF-PA transcription factor directly binds the sciarid BhC4-1 promoter.
Frank, Genesis (New York, N.Y. : 2000) 2017 (PubMed)- GeneRIF: Eip74EF-PA physically interacts with the Bradysia hygida BhC4-1 promoter.
- The Drosophila nuclear receptors DHR3 and betaFTZ-F1 control overlapping developmental responses in late embryos.
Ruaud, Development (Cambridge, England) 2010 - GeneRIF: Mid-embryonic expression of DHR3 and betaFTZ-F1 is part of a 20-hydroxyecdysone (20E)-triggered transcriptional cascade, directing maximal expression of E74A and E75A during late embryogenesis.
- The LARK RNA-binding protein selectively regulates the circadian eclosion rhythm by controlling E74 protein expression.
Huang, PloS one 2007 - GeneRIF: LARK RNA-binding protein selectively regulates the circadian eclosion rhythm by controlling E74 protein expression
- Steroid regulation of midgut cell death during Drosophila development.
Lee, Developmental biology 2002 (PubMed)- GeneRIF: mutations in the ecdysone-regulated E74A and E74B genes do not appear to perturb midgut development during metamorphosis
Q1KLR9 Transcription factor from Bombyx mori
51% identity, 30% coverage
- Developmental Expression of Ecdysone-Related Genes Associated With Metamorphic Changes During Midgut Remodeling of Silkworm Bombyx mori (Lepidoptera:Bombycidae)
Goncu, Journal of insect science (Online) 2016 - “...5-CAGGAACTCCATAGACCG-3 USP-2 5-CAGTGTCACATGTAGAGTGCAAAGA-3 AB182582 FAM-GTTCAACGACCTTGTTGCTGACAGGTTC-Tamra 5-CCACTTTCATAGAACAGTTCAGTTGC-3 Taqman probe E74A 5-CCACCTATCGAGATAAAGCAAGA-3 Q1KLS0 141 5-CTTGCAGTTGACTGCTGGAC-3 E74B 5-ACCCGAGTGACTACGTGAGG-3 Q1KLR9 95 5-CGGAGTCTGTGCCTGAGTCT-3 E75A 5-TCGGTCGAGCTTGAGTGAG-3 AB024904 59 5-GATGAAGGTCGCTTGTCTCG-3 E75B 5-GGACAGCTCTCAAAGACGTGA-3 AB024905 91 5-CGCACCATTCACTACACTCG-3 BR-C Z1 5-TCTGCAGAGTCCTCTCGCTTC-3 AB166725 36 5-TACACGCGCTGGCAAATG-3 BR-C Z2 5-TCTGCAGAGTCCTCTCGCTTC-3 AB166726 99 5-GTGTATATGTGCGTCATCAGGGA-3 BR-C Z4 5-TCTGCAGAGTCCTCTCGCTTC-3 AB166727 56 5-TCTTGTGGTTGTTGAGCGAGTT-3...”
XP_023021977 ecdysone-induced protein 74EF from Leptinotarsa decemlineata
51% identity, 22% coverage
Q60775 ETS-related transcription factor Elf-1 from Mus musculus
NP_031946 ETS-related transcription factor Elf-1 isoform 1 from Mus musculus
52% identity, 14% coverage
- Production of soluble mammalian proteins in Escherichia coli: identification of protein features that correlate with successful expression
Dyson, BMC biotechnology 2004 - “...1.0 0.0 0.0 36 ELF1 P32519 Ets 204306/619 12.1 6.0 0.0 65.0 19.3 37 Elf1 Q60775 Ets 2612/612 66.1 6.0 4.0 24.0 23.5 38 Elf1 Q60775 Ets 2306/612 34.0 6.0 3.0 60.6 27.2 39 Elf1 Q60775 na 2167/612 17.8 4.0 2.0 8.6 8.4 40 Elf1 Q60775...”
- “...1.0 15.5 10.4 41 Elf1 Q60775 Ets 204306/612 12.1 6.0 0.0 18.5 12.1 42 Elf1 Q60775 na 316612/612 30.7 3.0 0.0 0.0 0.0 43 Gata1 P17679 GATA 2 2413/413 42.5 3.0 6.0 16.0 14.3 44 Gata1 P17679 GATA 2 2319/413 33.8 3.0 5.0 67.0 15.8 45...”
- E74-like factor 1 contributes to nerve trauma-induced nociceptive hypersensitivity through transcriptionally activating matrix metalloprotein-9 in dorsal root ganglion neurons.
Zhang, Pain 2023 - GeneRIF: E74-like factor 1 contributes to nerve trauma-induced nociceptive hypersensitivity through transcriptionally activating matrix metalloprotein-9 in dorsal root ganglion neurons.
- ELF1/PRR11/ARP2/3 promoted trophoblast cells proliferation and motility in early pregnancy.
Zhu, American journal of reproductive immunology (New York, N.Y. : 1989) 2023 (PubMed)- GeneRIF: ELF1/PRR11/ARP2/3 promoted trophoblast cells proliferation and motility in early pregnancy.
- Increased Resistance to Intradermal Francisella tularensis LVS Infection by Inactivation of the Sts Phosphatases.
Parashar, Infection and immunity 2017 - GeneRIF: Herein, the authors demonstrate that mice lacking Sts expression are significantly resistant to infection by the live vaccine strain of Francisella tularensis.
- Green Tea Polyphenol EGCG Upregulates Tollip Expression by Suppressing Elf-1 Expression.
Kumazoe, Journal of immunology (Baltimore, Md. : 1950) 2017 (PubMed)- GeneRIF: Green Tea Polyphenol EGCG Upregulates Tollip Expression by Suppressing Elf-1 Expression
- Differential requirements for the Ets transcription factor Elf-1 in the development of NKT cells and NK cells.
Choi, Blood 2011 - GeneRIF: Whereas the proportion of NK cells in Elf-1(-/-) mice was normal, the proportion of NKT cells was significantly reduced in the thymus and periphery of Elf-1(-/-) mice compared with wild-type mice.
- The 1.35 A resolution structure of the phosphatase domain of the suppressor of T-cell receptor signaling protein in complex with sulfate.
Jakoncic, Acta crystallographica. Section F, Structural biology and crystallization communications 2010 - GeneRIF: crystal structure of the phosphatase domain of Sts-1, Sts-1(PGM), was determined at pH 4.6.The asymmetric unit contains two independent molecules and each active site is occupied by a sulfate ion.
- The Sts proteins target tyrosine phosphorylated, ubiquitinated proteins within TCR signaling pathways.
Carpino, Molecular immunology 2009 - GeneRIF: The Sts-1,2 proteins target tyrosine phosphorylated, ubiquitinated proteins within TCR signaling pathways.
- Ets factors and a newly identified polymorphism regulate Fli1 promoter activity in lymphocytes.
Nowling, Molecular immunology 2008 - GeneRIF: These results suggest that several Ets factors, including Fli1 itself, are involved in the transcriptional regulation of Fli1 in lymphocytes.
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ELF1_HUMAN / P32519 ETS-related transcription factor Elf-1; E74-like factor 1 from Homo sapiens (Human) (see 4 papers)
NP_758961 ETS-related transcription factor Elf-1 isoform a from Homo sapiens
52% identity, 14% coverage
- function: Transcription factor that activates the LYN and BLK promoters. Appears to be required for the T-cell-receptor-mediated trans activation of HIV-2 gene expression. Binds specifically to two purine-rich motifs in the HIV-2 enhancer.
subunit: Binds to the underphosphorylated form of RB. May interact with other transcription factors in order to regulate specific genes. Interacts with RUNX1. - The HLA Ligandome Comprises a Limited Repertoire of O-GlcNAcylated Antigens Preferentially Associated With HLA-B*07:02.
Mukherjee, Frontiers in immunology 2021 - “...APTSASNVM 9 P28324 ETS domain-containing protein Elk-4 Nucleus HLA-B*07:02 22 238-246 CS 14 VLTSNVQTI 9 P32519 ETS-related transcription factor Elf-1 Nucleus HLA-A*02:01 376 507-515 CS 15 RPPSSSQQL 9 Q8WYB5 Histone acetyltransferase KAT6B Nucleus HLA-B*07:02 70 17581766 ( 26 ) 16 LPRGSSPSVL 10 Q9GZN2 Homeobox protein TGIF2...”
- Reduced dosage of ERF causes complex craniosynostosis in humans and mice and links ERK1/2 signaling to regulation of osteogenesis.
Twigg, Nature genetics 2013 - “...NM_010155.3. Human ETS DNA-binding proteins (Swissprot): ERF, P50548; SPI1, P17947; ETV6, P41212; ELF3; P78545; ELF1, P32519; SPDEF, O95238; ETV4, P43268; ELK1, P19419; ETS1, P14921; ETV2, O00321; ERG, P11308; GABP, Q06546. Erf ChIP-Seq data: GSE42936 (GEO). References 1 Plotnikov A Zehorai E Procaccia S Seger R The...”
- Production of soluble mammalian proteins in Escherichia coli: identification of protein features that correlate with successful expression
Dyson, BMC biotechnology 2004 - “...(mg / l) 31 TAL1 P17542 HLH 179331/331 16.5 3.0 1.0 13.2 8.3 32 ELF1 P32519 Ets 2619/619 67.4 6.0 5.0 0.0 0.0 33 ELF1 P32519 na b 2167/619 18.0 4.0 2.0 14.6 14.6 34 ELF1 P32519 Ets 204619/619 45.4 6.0 2.0 0.0 0.0 35 ELF1...”
- Transcription Factor ELF1 Modulates Cisplatin Sensitivity in Prostate Cancer by Targeting MEIS Homeobox 2.
Han, Chemical research in toxicology 2023 (PubMed)- GeneRIF: Transcription Factor ELF1 Modulates Cisplatin Sensitivity in Prostate Cancer by Targeting MEIS Homeobox 2.
- ELF1 suppresses autophagy to reduce cisplatin resistance via the miR-152-3p/NCAM1/ERK axis in lung cancer cells.
Zhao, Cancer science 2023 - GeneRIF: ELF1 suppresses autophagy to reduce cisplatin resistance via the miR-152-3p/NCAM1/ERK axis in lung cancer cells.
- ELF1/PRR11/ARP2/3 promoted trophoblast cells proliferation and motility in early pregnancy.
Zhu, American journal of reproductive immunology (New York, N.Y. : 1989) 2023 (PubMed)- GeneRIF: ELF1/PRR11/ARP2/3 promoted trophoblast cells proliferation and motility in early pregnancy.
- ELF1 Transcription Factor Enhances the Progression of Glioma via ATF5 promoter.
Hu, ACS chemical neuroscience 2021 (PubMed)- GeneRIF: ELF1 Transcription Factor Enhances the Progression of Glioma via ATF5 promoter.
- ELF1-mediated LUCAT1 promotes choroidal melanoma by modulating RBX1 expression.
Wang, Cancer medicine 2020 - GeneRIF: ELF1-mediated LUCAT1 promotes choroidal melanoma by modulating RBX1 expression.
- ELF1 activated long non-coding RNA CASC2 inhibits cisplatin resistance of non-small cell lung cancer via the miR-18a/IRF-2 signaling pathway.
Xiao, European review for medical and pharmacological sciences 2020 (PubMed)- GeneRIF: ELF1 activated long non-coding RNA CASC2 inhibits cisplatin resistance of non-small cell lung cancer via the miR-18a/IRF-2 signaling pathway.
- Transcriptomic Analysis of Naïve Human Embryonic Stem Cells Cultured in Three-Dimensional PEG Scaffolds.
McKee, Biomolecules 2020 - GeneRIF: Transcriptomic Analysis of Naive Human Embryonic Stem Cells Cultured in Three-Dimensional PEG Scaffolds.
- Expression of ELF1, a lymphoid ETS domain-containing transcription factor, is recurrently lost in classical Hodgkin lymphoma.
Paczkowska, British journal of haematology 2019 (PubMed)- GeneRIF: We demonstrate that expression of ELF1 is impaired in cHL through genetic and epigenetic alterations, and thus, it may represent an additional member of a TF network whose downregulation contributes to the loss of B-cell phenotype of HRS cells.
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D3ZWM8 E74 like ETS transcription factor 4 from Rattus norvegicus
49% identity, 13% coverage
ELF4_HUMAN / Q99607 ETS-related transcription factor Elf-4; E74-like factor 4; Myeloid Elf-1-like factor from Homo sapiens (Human) (see 9 papers)
NP_001120669 ETS-related transcription factor Elf-4 from Homo sapiens
49% identity, 13% coverage
- function: Transcriptional activator that binds to DNA sequences containing the consensus 5'-WGGA-3'. Transactivates promoters of the hematopoietic growth factor genes CSF2, IL3, IL8, and of the bovine lysozyme gene. Acts synergistically with RUNX1 to transactivate the IL3 promoter (By similarity). Transactivates the PRF1 promoter in natural killer (NK) cells and CD8+ T cells (PubMed:34326534). Plays a role in the development and function of NK and NK T-cells and in innate immunity. Controls the proliferation and homing of CD8+ T-cells via the Kruppel-like factors KLF4 and KLF2 (By similarity). Controls cell senescence in a p53-dependent manner. Can also promote cellular transformation through inhibition of the p16 pathway. Is a transcriptional regulator of inflammation, controlling T-helper 17 (Th17) cells and macrophage inflammatory responses. Required for sustained transcription of anti-inflammatory genes, including IL1RN (PubMed:34326534, PubMed:35266071). Is a negative regulator of pro- inflammatory cytokines expression including IL17A, IL1B, IL6, TNFA and CXCL1 (PubMed:34326534, PubMed:35266071). Down-regulates expression of TREM1, a cell surface receptor involved in the amplification of inflammatory responses (By similarity) (PubMed:34326534, PubMed:35266071).
subunit: Interacts with RUNX1 (via the Runt domain); the interaction transactivates the IL3 promoter. Interacts (via its C-terminus) with PML; the interaction translocates ELF4 to PML nuclear bodies and enhances transactivation of LYZ. - ELF4 contributes to esophageal squamous cell carcinoma growth and metastasis by augmenting cancer stemness via FUT9.
Xu, Acta biochimica et biophysica Sinica 2024 - GeneRIF: ELF4 contributes to esophageal squamous cell carcinoma growth and metastasis by augmenting cancer stemness via FUT9.
- Reciprocal regulation of lncRNA MEF and c-Myc drives colorectal cancer tumorigenesis.
Wu, Neoplasia (New York, N.Y.) 2024 - GeneRIF: Reciprocal regulation of lncRNA MEF and c-Myc drives colorectal cancer tumorigenesis.
- A Novel Frameshift Variant of the ELF4 Gene in a Patient with Autoinflammatory Disease: Clinical Features, Transcriptomic Profiling and Functional Studies.
Sun, Journal of clinical immunology 2024 (PubMed)- GeneRIF: A Novel Frameshift Variant of the ELF4 Gene in a Patient with Autoinflammatory Disease: Clinical Features, Transcriptomic Profiling and Functional Studies.
- ELF4 is a critical component of a miRNA-transcription factor network and is a bridge regulator of glioblastoma receptor signaling and lipid dynamics.
Kosti, Neuro-oncology 2023 - GeneRIF: ELF4 is a critical component of a miRNA-transcription factor network and is a bridge regulator of glioblastoma receptor signaling and lipid dynamics.
- A Multicenter Cohort Study of Immune Dysregulation Disorders Caused by ELF4 Variants in China.
Sun, Journal of clinical immunology 2023 (PubMed)- GeneRIF: A Multicenter Cohort Study of Immune Dysregulation Disorders Caused by ELF4 Variants in China.
- FGF19-mediated ELF4 overexpression promotes colorectal cancer metastasis through transactivating FGFR4 and SRC.
Chen, Theranostics 2023 - GeneRIF: FGF19-mediated ELF4 overexpression promotes colorectal cancer metastasis through transactivating FGFR4 and SRC.
- Loss of Function Mutation in ELF4 Causes Autoinflammatory and Immunodeficiency Disease in Human.
Sun, Journal of clinical immunology 2022 (PubMed)- GeneRIF: Loss of Function Mutation in ELF4 Causes Autoinflammatory and Immunodeficiency Disease in Human.
- An ELF4 hypomorphic variant results in NK cell deficiency.
Salinas, JCI insight 2022 - GeneRIF: An ELF4 hypomorphic variant results in NK cell deficiency.
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- Ethinylestradiol in combined hormonal contraceptive has a broader effect on serum proteome compared with estradiol valerate: a randomized controlled trial.
Kangasniemi, Human reproduction (Oxford, England) 2023 - “...S NS P22460 KCNA5 Voltage-gated potassium channel HK2 Q8N1V2 CFAP52 Cilia- and flagella-associated protein 52 Q99607 ELF4 ETS-related transcription factor Elf-4 Q9UH62 ARMCX3 Armadillo repeat-containing X-linked protein 3 Q9Y2M5 KLHL20 Kelch-like protein 20 HIGH P01009 SERPINA1 Alpha-1-antitrypsin 1.4 * 1.0 1.0 S S NS LOW A5A3E0...”
- A manually curated network of the PML nuclear body interactome reveals an important role for PML-NBs in SUMOylation dynamics
Van, International journal of biological sciences 2010 - “...binding form 134 + Q9UJU2 LEF1 SUMOylation induces potent repression of LEF1 activity 135 - Q99607 MEF/ELF4 K657 SUMOylation down-regulates ELF4 activity 136 - Q15596 NCOA2 (human, GRIP1 mouse NDSM K239, K731, K788 SUMOylation of GRIP1 (mouse equivalent of NCOA2) enhances binding to the androgen receptor...”
ELF4_MOUSE / Q9Z2U4 ETS-related transcription factor Elf-4; E74-like factor 4; Myeloid Elf-1-like factor from Mus musculus (Mouse) (see 5 papers)
NP_062654 ETS-related transcription factor Elf-4 from Mus musculus
49% identity, 14% coverage
- function: Transcriptional activator that binds to DNA sequences containing the consensus 5'-WGGA-3'. Transactivates promoters of the hematopoietic growth factor genes CSF2, IL3, IL8, and of LYZ. Acts synergistically with RUNX1 to transactivate the IL3 promoter (By similarity). Transactivates the PRF1 promoter in natural killer (NK) cells and in CD8+ T cells (PubMed:34326534). Plays a role in the development and function of NK and NK T-cells and in innate immunity. Controls the proliferation and homing of CD8+ T-cells via the Kruppel- like factors KLF4 and KLF2. Controls cell senescence in a p53-dependent manner. Can also promote cellular transformation through inhibition of the p16 pathway. Is a transcriptional regulator of inflammation, controlling T-helper 17 (Th17) cells and macrophage inflammatory responses. Required for sustained transcription of anti-inflammatory genes, including IL1RN (PubMed:34326534, PubMed:35266071). Is a negative regulator of pro-inflammatory cytokines expression, including IL17A, IL1B, IL6, TNFA and CXCL1 (PubMed:34326534, PubMed:35266071). Down-regulates expression of TREM1, a cell surface receptor involved in the amplification of inflammatory responses (PubMed:34326534, PubMed:35266071).
subunit: Interacts with RUNX1 (via the Runt domain); the interaction transactivates the IL3 promoter. Interacts (via its C-terminus) with PML; the interaction translocates ELF4 to PML nuclear bodies and enhances transactivation of LYZ (By similarity). - The construction of an EST database for Bombyx mori and its application.
Mita, Proceedings of the National Academy of Sciences of the United States of America 2003 - White adipocyte-derived exosomal miR-23b inhibits thermogenesis by targeting Elf4 to regulate GLP-1R transcription.
Wang, Naunyn-Schmiedeberg's archives of pharmacology 2024 (PubMed)- GeneRIF: White adipocyte-derived exosomal miR-23b inhibits thermogenesis by targeting Elf4 to regulate GLP-1R transcription.
- The transcription factor ELF4 alleviates inflammatory bowel disease by activating IL1RN transcription, suppressing inflammatory TH17 cell activity, and inducing macrophage M2 polarization.
Cao, Frontiers in immunology 2023 - GeneRIF: The transcription factor ELF4 alleviates inflammatory bowel disease by activating IL1RN transcription, suppressing inflammatory TH17 cell activity, and inducing macrophage M2 polarization.
- An ELF4 hypomorphic variant results in NK cell deficiency.
Salinas, JCI insight 2022 - GeneRIF: An ELF4 hypomorphic variant results in NK cell deficiency.
- ELF4 facilitates innate host defenses against Plasmodium by activating transcription of Pf4 and Ppbp.
Wang, The Journal of biological chemistry 2019 - GeneRIF: that E74, like ETS transcription factor 4 (ELF4), a type I interferon activator, can help protect the host from Plasmodium yoelii infection.
- The transcription factor E74-like factor 4 suppresses differentiation of proliferating CD4+ T cells to the Th17 lineage.
Lee, Journal of immunology (Baltimore, Md. : 1950) 2014 - GeneRIF: ELF4 restrains Th17 differentiation in dividing CD4(+) T cells by regulating commitment to the Th17 differentiation program.
- Transcription factor ELF4 promotes development and function of memory CD8(+) T cells in Listeria monocytogenes infection.
Mamonkin, European journal of immunology 2014 (PubMed)- GeneRIF: Transcription factor ELF4 promotes development and function of memory CD8(+) T cells in Listeria monocytogenes infection.
- ELF4 is critical for induction of type I interferon and the host antiviral response.
You, Nature immunology 2013 - GeneRIF: Data indicate that ELF4 is an type I interferon stimulator and binds to STING.
- Integration of Elf-4 into stem/progenitor and erythroid regulatory networks through locus-wide chromatin studies coupled with in vivo functional validation.
Smith, Molecular and cellular biology 2012 - GeneRIF: transcriptional control of Elf-4 within the hematopoietic system and integration of Elf-4 into the wider transcriptional regulatory networks that govern hematopoietic development
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LOC113216945 ecdysone-induced protein 74EF from Frankliniella occidentalis
51% identity, 49% coverage
NP_001277988 ETS-related transcription factor Elf-2 isoform 2 from Mus musculus
51% identity, 14% coverage
XP_006232387 ETS-related transcription factor Elf-2 isoform X1 from Rattus norvegicus
51% identity, 14% coverage
NP_973728 ETS-related transcription factor Elf-2 isoform 1 from Homo sapiens
51% identity, 14% coverage
- c-Myc-induced long noncoding RNA MIRE cooperates with hnRNPK to stabilize ELF2 mRNA and promotes clear cell renal cell carcinogenesis.
Li, Cancer gene therapy 2023 (PubMed)- GeneRIF: c-Myc-induced long noncoding RNA MIRE cooperates with hnRNPK to stabilize ELF2 mRNA and promotes clear cell renal cell carcinogenesis.
- Circ_0028007 Aggravates the Malignancy of Nasopharyngeal Carcinoma by Regulating miR-656-3p/ELF2 Axis.
Ma, Biochemical genetics 2022 (PubMed)- GeneRIF: Circ_0028007 Aggravates the Malignancy of Nasopharyngeal Carcinoma by Regulating miR-656-3p/ELF2 Axis.
- EIF2B2 mutations in vanishing white matter disease hypersuppress translation and delay recovery during the integrated stress response.
Moon, RNA (New York, N.Y.) 2018 - GeneRIF: Mutations in eIF2B genes cause vanishing white matter disease due to translation defects.
- Long non-coding RNA PCAT7 regulates ELF2 signaling through inhibition of miR-134-5p in nasopharyngeal carcinoma.
Liu, Biochemical and biophysical research communications 2017 (PubMed)- GeneRIF: PCAT7 contributed to the progression of nasopharyngeal carcinoma through regulating miR-134-5p/ELF2 signaling pathway.
- ChIP-on-chip analysis of thyroid hormone-regulated genes and their physiological significance.
Chung, Oncotarget 2016 - GeneRIF: Our findings collectively support a potential role of triiodothyronine and its receptor in tumor growth inhibition through regulation of ELF2
- E74-like factor 2 transactivates valosin-containing protein gene, a gene involved in cancer growth.
Qiu, Experimental and molecular pathology 2008 (PubMed)- GeneRIF: ELF2 transactivates VCP promoter through binding to two motifs, with a predominant contribution of the upstream one.
- The relative binding affinities of PDZ partners for CFTR: a biochemical basis for efficient endocytic recycling.
Cushing, Biochemistry 2008 - GeneRIF: Affinity of the CAL PDZ domain for the cystic fibrosis transmembrane conductance regulator (CFTR) C-terminus is much weaker than that of the NHERF1/NHERF2 domains, enabling wild-type CFTR to avoid premature entrapment in the lysosomal pathway.
- E74-like factor 2 regulates valosin-containing protein expression.
Zhang, Biochemical and biophysical research communications 2007 (PubMed)- GeneRIF: These findings indicate that ELF2/NERF promotes VCP transcription and that ELF2/NERF-VCP pathway might be important for cell survival and proliferation under cytokine stress.
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ELF2_HUMAN / Q15723 ETS-related transcription factor Elf-2; E74-like factor 2; New ETS-related factor from Homo sapiens (Human) (see 3 papers)
51% identity, 14% coverage
- function: Isoform 1 transcriptionally activates the LYN and BLK promoters and acts synergistically with RUNX1 to transactivate the BLK promoter
function: Isoform 2 may function in repression of RUNX1-mediated transactivation
subunit: Interacts with the LIM domains of LMO2 (By similarity). Interacts via its N-terminal region with RUNX1.
ELF2_MOUSE / Q9JHC9 ETS-related transcription factor Elf-2; E74-like factor 2; New ETS-related factor from Mus musculus (Mouse) (see paper)
51% identity, 14% coverage
- function: Probably transcriptionally activates the LYN and BLK promoters and acts synergistically with RUNX1 to transactivate the BLK promoter.
subunit: Interacts with LIM domains of LMO2. Interacts via its N- terminal region with RUNX1.
NP_001266436 ets DNA-binding protein pokkuri-like from Bombyx mori
49% identity, 17% coverage
SPDEF_HUMAN / O95238 SAM pointed domain-containing Ets transcription factor; Prostate epithelium-specific Ets transcription factor; Prostate-specific Ets; Prostate-derived Ets factor from Homo sapiens (Human) (see 3 papers)
55% identity, 24% coverage
- function: May function as an androgen-independent transactivator of the prostate-specific antigen (PSA) promoter. Binds to 5'-GGAT-3' DNA sequences. May play a role in the regulation of the prostate gland and/or prostate cancer development. Acts as a transcriptional activator for SERPINB5 promoter.
subunit: Interacts with the DNA-binding domain of the androgen receptor. Interacts with NKX3-1. - The Stress Response of the Holothurian Central Nervous System: A Transcriptomic Analysis.
Cruz-González, International journal of molecular sciences 2022 - “...RPS5 P46782 Structural constituent of ribosome Downregulated MRPL12 Q7YR75 Structural constituent of ribosome Downregulated SPDEF O95238 Transcription factor Downregulated DMBT1 Q9UGM3 DNA binding Upregulated BAG3 O95817 Heat shock protein binding Upregulated DYRK2 Q5ZIU3 Regulation of cell growth and development Upregulated WARS2 Q9UGM6 Mitochondrial tRNA ligase (tryptophan)...”
- Circulating Levels of Interferon Regulatory Factor-5 Associates With Subgroups of Systemic Lupus Erythematosus Patients.
Idborg, Frontiers in immunology 2019 - “...interstitial collagenase) P03956 0.63 0.17 3.2E-06 SPDEF * SAM pointed domain containing ETS transcription factor O95238 0.87 0.14 1.3E-02 UBAC1 UBA domain containing 1 Q9BSL1 0.71 0.13 1.4E-04 TRIM33 Tripartite motif containing 33 Q9UPN9 0.84 0.13 3.0E-03 CFI Complement factor I P05156 0.65 0.13 2.9E-02 APOL6...”
- Reduced dosage of ERF causes complex craniosynostosis in humans and mice and links ERK1/2 signaling to regulation of osteogenesis.
Twigg, Nature genetics 2013 - “...ETS DNA-binding proteins (Swissprot): ERF, P50548; SPI1, P17947; ETV6, P41212; ELF3; P78545; ELF1, P32519; SPDEF, O95238; ETV4, P43268; ELK1, P19419; ETS1, P14921; ETV2, O00321; ERG, P11308; GABP, Q06546. Erf ChIP-Seq data: GSE42936 (GEO). References 1 Plotnikov A Zehorai E Procaccia S Seger R The MAPK cascades:...”
NP_001239223 SAM pointed domain-containing Ets transcription factor isoform 2 from Homo sapiens
55% identity, 25% coverage
SPDEF_MOUSE / Q9WTP3 SAM pointed domain-containing Ets transcription factor; Prostate epithelium-specific Ets transcription factor; Prostate-specific Ets; Prostate-derived Ets factor from Mus musculus (Mouse) (see paper)
54% identity, 25% coverage
- function: May function as an androgen-independent transactivator of the prostate-specific antigen (PSA) promoter. Binds to 5'-GGAT-3' DNA sequences. May play a role in the regulation of the prostate gland and/or prostate cancer development. Acts as a transcriptional activator for SERPINB5 promoter (By similarity).
subunit: Interacts with the DNA-binding domain of the androgen receptor. Interacts with NKX3-1 (By similarity).
POK_DROME / Q01842 Ets DNA-binding protein pokkuri; Protein anterior open; Protein yan from Drosophila melanogaster (Fruit fly) (see 3 papers)
NP_523455 anterior open, isoform B from Drosophila melanogaster
49% identity, 11% coverage
- function: Ets-related protein that functions as a negative regulator of photoreceptor development acting antagonistically to pnt and the proneural signal mediated by RAS (PubMed:1495974, PubMed:1505027, PubMed:8033205). It acts upstream of SINA to inhibit R7 development (PubMed:1495974, PubMed:1505027).
- Longevity is determined by ETS transcription factors in multiple tissues and diverse species.
Dobson, PLoS genetics 2019 - GeneRIF: In Drosophila, reduced insulin/IGF signaling extends lifespan by coordinating activation of Aop and Foxo. Aop and Foxo bind the same genomic loci, and individually, they affect similar transcriptional programs in vivo. In combination, Aop can both moderate or synergise with Foxo, dependent on promoter context. Also, Foxo and Aop oppose the gene-regulatory activity of Pnt.
- Cooperative recruitment of Yan via a high-affinity ETS supersite organizes repression to confer specificity and robustness to cardiac cell fate specification.
Boisclair, Genes & development 2018 - GeneRIF: Yan recruitment promoted by this high-affinity ETS supersite not only biases Yan-Pnt competition at the specific CRM but also organizes Yan-repressive complexes in three dimensions across the eve locus
- Collaborative repressive action of the antagonistic ETS transcription factors Pointed and Yan fine-tunes gene expression to confer robustness in Drosophila.
Webber, Development (Cambridge, England) 2018 - GeneRIF: a new layer of regulation whereby Yan and Pointed co-occupy regulatory elements to repress gene expression in a coordinated manner, with Pointed being unexpectedly required for the genome-wide occupancy of both Yan and the co-repressor Groucho.
- Tuned polymerization of the transcription factor Yan limits off-DNA sequestration to confer context-specific repression.
Hope, eLife 2018 - GeneRIF: a spectacular range of affinities lies latent within the SAM domain of Yan, and that these affinities must be tuned to preserve transcriptional repression and biological function during development.
- DNA Occupancy of Polymerizing Transcription Factors: A Chemical Model of the ETS Family Factor Yan.
Hope, Biophysical journal 2017 - GeneRIF: DNA Occupancy of Polymerizing Transcription Factors
- acal is a long non-coding RNA in JNK signaling in epithelial shape changes during drosophila dorsal closure.
Ríos-Barrera, PLoS genetics 2015 - GeneRIF: We show that acal lies downstream of raw, a pioneer protein and interacts genetically with two genes involved in JNK signaling and dorsal closure: Connector of kinase to AP1 (Cka) and anterior open.
- The Ras-Erk-ETS-Signaling Pathway Is a Drug Target for Longevity.
Slack, Cell 2015 - GeneRIF: Study identifies the E-twenty six (ETS) transcriptional repressor, Anterior open (Aop), as central to lifespan extension caused by reduced insulin/IGF-1 or Ras attenuation.
- A comparative study of Pointed and Yan expression reveals new complexity to the transcriptional networks downstream of receptor tyrosine kinase signaling.
Boisclair, Developmental biology 2014 - GeneRIF: instances of co-expressed Yan and Pnt-GFP in tissues with high RTK signaling cannot be explained by the current model, and thus they provide important contexts for future investigation of how context-specific differences in RTK signaling
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- The transcriptome of Icerya aegyptiaca (Hemiptera: Monophlebidae) and comparison with neococcoids reveal genetic clues of evolution in the scale insects
Tang, BMC genomics 2023 - “...epsilon DNA replication and repair [ 52 ] OG0004313 I. aegyptiaca Positive selection <0.001 0.003 Q01842 Ets DNA-binding protein pokkuri early development of compound eyes [ 53 ] OG0006586 I. aegyptiaca Positive selection <0.001 0.046 Q8IMC6 Tau-tubulin kinase homolog Asator activation of spindle in mitosis [...”
- “...A1Z6E0 Protein Gustavus Arthropod reproduction [ 55 ] OG0004313 Neococcoid ancestor Positive selection <0.001 0.026 Q01842 Ets DNA-binding protein pokkuri early development of compound eyes [ 53 ] OG0006586 Neococcoid ancestor Positive selection <0.001 0.033 Q8IMC6 Tau-tubulin kinase homolog Asator activation of spindle in mitosis [...”
- Trinucleotide repeats and long homopeptides in genes and proteins associated with nervous system disease and development
Karlin, Proceedings of the National Academy of Sciences of the United States of America 1996 - “...(P10105) GRH/ELF1 (P13002) Suppressor 2 of zeste (P25172) Yan (Q01842) Daughterless (P11420) Stubble (Q05319) Empty spiracles 549 483 590 517 429 671 972 G6 A8,...”
Q30JB6 ETS variant transcription factor 2 from Danio rerio
56% identity, 22% coverage
- Crystal Structure of FOXC2 in Complex with DNA Target.
Li, ACS omega 2019 - “...synergistically activate downstream targets. 40 In zebrafish, FOXC2 together with ETS variant 2 (ETV2, UniProtKB Q30JB6) transcription factors control angiogenetic processes, and the two proteins are required for blood vessel formation. 40 One of the downstream targets activated by FOXC2 and ETV2 is the myocyte-specific enhancer...”
pok / BAA01080.1 Ets domain protein from Drosophila melanogaster (see paper)
49% identity, 11% coverage
XP_005158270 ETS1-related protein isoform X1 from Danio rerio
56% identity, 23% coverage
- Single-cell transcriptomic analysis identifies the conversion of zebrafish Etv2-deficient vascular progenitors into skeletal muscle.
Chestnut, Nature communications 2020 - GeneRIF: Single-cell transcriptomic analysis identifies the conversion of zebrafish Etv2-deficient vascular progenitors into skeletal muscle.
- Ets1 functions partially redundantly with Etv2 to promote embryonic vasculogenesis and angiogenesis in zebrafish.
Casie, Developmental biology 2020 - GeneRIF: Ets1 functions partially redundantly with Etv2 to promote embryonic vasculogenesis and angiogenesis in zebrafish.
- ETS transcription factors Etv2 and Fli1b are required for tumor angiogenesis.
Baltrunaite, Angiogenesis 2017 - GeneRIF: These results demonstrate the requirement for Etv2 and Fli1b in tumor angiogenesis.
- Vegf signaling promotes vascular endothelial differentiation by modulating etv2 expression.
Casie, Developmental biology 2017 - GeneRIF: low levels of Vegf signaling promote overall vascular endothelial differentiation and cell survival by upregulating etv2 expression, while high levels of Vegf signaling promote arterial and inhibit venous specification.
- Etv2 and fli1b function together as key regulators of vasculogenesis and angiogenesis.
Craig, Arteriosclerosis, thrombosis, and vascular biology 2015 - GeneRIF: Etv2 alone is required for early vasculogenesis, whereas Etv2 and Fli1b function redundantly during late vasculogenesis and early embryonic angiogenesis.
- LSD1/KDM1A promotes hematopoietic commitment of hemangioblasts through downregulation of Etv2.
Takeuchi, Proceedings of the National Academy of Sciences of the United States of America 2015 - GeneRIF: results suggest that the LSD1-dependent shutdown of Etv2 gene expression may be a significant event required for hemangioblasts to initiate hematopoietic differentiation
- Distinct regulation of the anterior and posterior myeloperoxidase expression by Etv2 and Gata1 during primitive Granulopoiesis in zebrafish.
Glenn, Developmental biology 2014 - GeneRIF: etv2 has a critical cell autonomous requirement during neutropoiesis in the anterior lateral plate mesoderm.
- Transcriptional inhibition of etv2 expression is essential for embryonic cardiac development.
Schupp, Developmental biology 2014 - GeneRIF: The results identify an etv2 cis-regulatory mechanism controlling cardiovascular fate choice implying that etv2 participates in a transcriptional network mediating developmental plasticity of endothelial progenitor cells during embryonic development.
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8bzmH / P32519 Foxk1-elf1-heterodimer bound to DNA
51% identity, 97% coverage
ELF3_HUMAN / P78545 ETS-related transcription factor Elf-3; E74-like factor 3; Epithelial-restricted with serine box; Epithelium-restricted Ets protein ESX; Epithelium-specific Ets transcription factor 1; ESE-1 from Homo sapiens (Human) (see 24 papers)
46% identity, 21% coverage
- function: Transcriptional activator that binds and transactivates ETS sequences containing the consensus nucleotide core sequence GGA[AT]. Acts synergistically with POU2F3 to transactivate the SPRR2A promoter and with RUNX1 to transactivate the ANGPT1 promoter. Also transactivates collagenase, CCL20, CLND7, FLG, KRT8, NOS2, PTGS2, SPRR2B, TGFBR2 and TGM3 promoters. Represses KRT4 promoter activity. Involved in mediating vascular inflammation. May play an important role in epithelial cell differentiation and tumorigenesis. May be a critical downstream effector of the ERBB2 signaling pathway. May be associated with mammary gland development and involution. Plays an important role in the regulation of transcription with TATA-less promoters in preimplantation embryos, which is essential in preimplantation development (By similarity).
subunit: Interacts with TBP. Interacts with CREBBP and EP300; these act as transcriptional coactivators of ELF3 and positively modulate its function. Interacts with XRCC5/KU86 and XRCC6/KU70; these inhibit the ability of ELF3 to bind DNA and negatively modulate its transcriptional activity. Associated with CLND7 and POU2F3. Interacts with ZNF768 (PubMed:30476274). - A virus-target host proteins recognition method based on integrated complexes data and seed extension.
Xia, BMC bioinformatics 2022 - “...GO:0005829; GO:0043547; 1(RALBP1) GO:0042910; GO:0016020; GO:0007264; GO:0005096; GO:1990961; GO:0042626; GO:0051056; GO:0022857; GO:0043087; GO:0006935; GO:0006897; GO:0055085; P78545 E74 like ETS transcription GO:0005515; GO:0005654; GO:0045892; Factor 3(ELF3) GO:0000978; GO:0005829; GO:0045944; GO:0001228; GO:0005634; GO:0006366; GO:1990837; GO:0005794; GO:0045747; GO:0003700; GO:0006357; GO:0000981; GO:0030855; GO:0060056; GO:0006954; GO:0001824; GO:0030198; GO:0030154; To verify the...”
- Deciphering the mechanism of Indirubin and its derivatives in the inhibition of Imatinib resistance using a "drug target prediction-gene microarray analysis-protein network construction" strategy
Li, BMC complementary and alternative medicine 2019 - “...Substance-P receptor P25103 TACR1 MT26 Wilms tumor protein P19544 WT1 MT27 ETS-related transcription factor Elf-3 P78545 ELF3 MT28 G1/S-specific cyclin-D2 P30279 CCND2 MT29 Amine oxidase [flavin-containing] A P21397 MAOA MT30 Metalloproteinase inhibitor 1 P20414 TIMP1 MT31 Kinesin-like protein KIF11 P52732 KIF11 MT32 Cell division cycle protein...”
- Comparison of protein expression during wild-type, and E1B-55k-deletion, adenovirus infection using quantitative time-course proteomics.
Fu, The Journal of general virology 2017 - “...MAP3K7 0.7 P35869 Aryl hydrocarbon receptor AHR 0.29 Q8NCD3 Holliday junction recognition protein HJURP 0.11 P78545 ETS-related transcription factor Elf-3 ELF3 0.07 Q07973 1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial CYP24A1 0.18 A0A087WWW9 B-cell lymphoma/leukaemia 10 BCL10 0.31 P35354 Prostaglandin G/H synthase 2 PTGS2 0 Q59GZ8 Urokinase plasminogen activator...”
- High-throughput quantitative proteomic analysis of dengue virus type 2 infected A549 cells.
Chiu, PloS one 2014 - “...Rab-8B 0.16 2 7.6310 104 May be involved in vesicular trafficking and neurotransmitter release. ELF3 P78545 ETS-related transcription factor Elf-3 0.27 2 1.5310 7 Transcriptional activator that binds and transactivates sequences containing the consensus nucleotide core sequence GGA[AT]. BRD8 Q9H0E9 Bromodomain-containing protein 8 0.31 2 2.9710...”
- Reduced dosage of ERF causes complex craniosynostosis in humans and mice and links ERK1/2 signaling to regulation of osteogenesis.
Twigg, Nature genetics 2013 - “...reference sequence NM_010155.3. Human ETS DNA-binding proteins (Swissprot): ERF, P50548; SPI1, P17947; ETV6, P41212; ELF3; P78545; ELF1, P32519; SPDEF, O95238; ETV4, P43268; ELK1, P19419; ETS1, P14921; ETV2, O00321; ERG, P11308; GABP, Q06546. Erf ChIP-Seq data: GSE42936 (GEO). References 1 Plotnikov A Zehorai E Procaccia S Seger...”
- Gene expression pattern in Caco-2 cells following rotavirus infection
Cuadras, Journal of virology 2002 - “...2.3 2.4 2.5 0.5 Q14188 P01100 P15407 P05412 P18848 P19838 O00221 P78545 Q15652 P57722 Q9UIG1 2.5 6.6 15 17 2.7 2.4 5.4 3.8 2.6 2.3 2.4 Q9BYH8 Q03060 6.4 5.4...”
1yo5C / O95238 Analysis of the 2.0a crystal structure of the protein-DNA complex of human pdef ets domain bound to the prostate specific antigen regulatory site (see paper)
54% identity, 92% coverage
ELF3_MOUSE / Q3UPW2 ETS-related transcription factor Elf-3; E74-like factor 3; Epithelial-restricted with serine box; Epithelium-restricted Ets protein ESX; Epithelium-specific Ets transcription factor 1; ESE-1 from Mus musculus (Mouse) (see 8 papers)
46% identity, 20% coverage
- function: Transcriptional activator that binds and transactivates ETS sequences containing the consensus nucleotide core sequence GGA[AT]. Acts synergistically with POU2F3 to transactivate the SPRR2A promoter and with RUNX1 to transactivate the ANGPT1 promoter (By similarity). Also transactivates collagenase, CCL20, CLND7, FLG, KRT8, NOS2, PTGS2, SPRR2B, TGFBR2 and TGM3 promoters. Represses KRT4 promoter activity (By similarity). Involved in mediating vascular inflammation. May play an important role in epithelial cell differentiation and tumorigenesis. May be a critical downstream effector of the ERBB2 signaling pathway (By similarity). May be associated with mammary gland development and involution. Plays an important role in the regulation of transcription with TATA-less promoters in preimplantation embryos, which is essential in preimplantation development.
subunit: Interacts with TBP. Interacts with CREBBP and EP300; these act as transcriptional coactivators of ELF3 and positively modulate its function. Interacts with XRCC5/KU86 and XRCC6/KU70; these inhibit the ability of ELF3 to bind DNA and negatively modulate its transcriptional activity. Associated with CLND7 and POU2F3 (By similarity). Interacts with ZNF768 (By similarity).
disruption phenotype: Mice show about 30% fetal lethality at around 11.5 dpc. Approximately 70% of the mutant progeny are born and display severe alterations in tissue architecture in the small intestine. Elf3- deficient enterocytes express markedly reduced levels of TGFBR2. - Transcription Factor Elf3 Modulates Vasopressin-Induced Aquaporin-2 Gene Expression in Kidney Collecting Duct Cells.
Lin, Frontiers in physiology 2019 - “...Elf3 isoform 2 is shorter than isoform 1 by 20 amino acids (5473, Uniprot accession Q3UPW2) in the pointed domain that is not involved in DNA binding. To examine their functions in vasopressin-induced AQP2 gene expression, V5-tagged Elf3 isoform 1 or 2 was selectively overexpressed in...”
ETS4_DROME / P29775 DNA-binding protein D-ETS-4 from Drosophila melanogaster (Fruit fly) (see paper)
NP_524535 Ets at 98B, isoform A from Drosophila melanogaster
53% identity, 16% coverage
XP_006249945 ETS-related transcription factor Elf-3 isoform X4 from Rattus norvegicus
46% identity, 21% coverage
XP_002666146 ETS-related transcription factor Elf-3 from Danio rerio
48% identity, 21% coverage
3jtgA / Q3UPW2 Crystal structure of mouse elf3 c-terminal DNA-binding domain in complex with type ii tgf-beta receptor promoter DNA (see paper)
45% identity, 85% coverage
XP_018109474 ETS variant transcription factor 6 S homeolog isoform X2 from Xenopus laevis
42% identity, 21% coverage
Q9Y603 Transcription factor ETV7 from Homo sapiens
45% identity, 24% coverage
- Combining patient proteomics and in vitro cardiomyocyte phenotype testing to identify potential mediators of heart failure with preserved ejection fraction
Raphael, Journal of translational medicine 2016 - “...Q9NR50 Translation initiation factor eIF-2B subunit gamma NBPFL A6NDD8 Neuroblastoma breakpoint family member 21 ETV7 Q9Y603 Transcription factor ETV7 Table4 Proteins preferential to either HFpEF or control groups Protein Accession Description p value Proteins preferentially found in HFpEF group SAA2 P0DJI9 Serum amyloid A-2 protein 0.0019...”
- Comparative proteome analysis of Tumor necrosis factor α-stimulated human Vascular Smooth Muscle Cells in response to melittin.
Cho, Proteome science 2013 - “...subunit beta - 3 CM Transport 920 31 6. 9 0. 589 2. 289 16 Q9Y603 Transcription factor ETV7 N Repressor 142 38 8. 3 3. 929 0. 39 17 Q17RB8 LON peptidase N - terminal domain and RING finger protein 1 M Proteolysis 133 47...”
- Acetylation Increases EWS-FLI1 DNA Binding and Transcriptional Activity.
Schlottmann, Frontiers in oncology 2012 - “...members at relevant lysine positions. Protein sequences of ETS1 (P14921), ETS2 (P15036), ETV6 (P41212), ETV7 (Q9Y603), SPIB (Q01892), SPI1 (P17947), ETV1 (P50549), ETV5 (P41161), ETV4 (P43268), ERG (P11308), FLI1 (Q01543), FEV (Q99581), and ETV2 (O00321) were aligned using UniProt, to reveal conservation of Lysine positions K240,...”
NP_571907 transcription factor ETV6 from Danio rerio
42% identity, 19% coverage
EHF_MOUSE / O70273 ETS homologous factor; ETS domain-containing transcription factor from Mus musculus (Mouse) (see 3 papers)
45% identity, 27% coverage
- function: Transcriptional activator that may play a role in regulating epithelial cell differentiation and proliferation. May act as a repressor for a specific subset of ETS/AP-1-responsive genes, and as a modulator of the nuclear response to mitogen-activated protein kinase signaling cascades. Binds to DNA sequences containing the consensus nucleotide core sequence GGAA. Involved in regulation of TNFRSF10B/DR5 expression through Ets-binding sequences on the TNFRSF10B/DR5 promoter (By similarity).
XP_006498766 ETS homologous factor isoform X3 from Mus musculus
45% identity, 27% coverage
EHF_HUMAN / Q9NZC4 ETS homologous factor; hEHF; ETS domain-containing transcription factor; Epithelium-specific Ets transcription factor 3; ESE-3 from Homo sapiens (Human) (see 6 papers)
NP_036285 ETS homologous factor isoform 2 from Homo sapiens
45% identity, 27% coverage
- function: Transcriptional activator that may play a role in regulating epithelial cell differentiation and proliferation. May act as a repressor for a specific subset of ETS/AP-1-responsive genes and as a modulator of the nuclear response to mitogen-activated protein kinase signaling cascades. Binds to DNA sequences containing the consensus nucleotide core sequence GGAA. Involved in regulation of TNFRSF10B/DR5 expression through Ets-binding sequences on the TNFRSF10B/DR5 promoter. May contribute to development and carcinogenesis by acting as a tumor suppressor gene or anti-oncogene.
- Ehf controls mammary alveolar lineage differentiation and is a putative suppressor of breast tumorigenesis.
Nightingale, Developmental cell 2024 (PubMed)- GeneRIF: Ehf controls mammary alveolar lineage differentiation and is a putative suppressor of breast tumorigenesis.
- ETS homologous factor, controlled by lysine-specific demethylase 5B, suppresses clear cell renal cell carcinoma by inducing Filamin-B.
Wang, Gene 2024 (PubMed)- GeneRIF: ETS homologous factor, controlled by lysine-specific demethylase 5B, suppresses clear cell renal cell carcinoma by inducing Filamin-B.
- Loss of EHF facilitates the development of treatment-induced neuroendocrine prostate cancer.
Long, Cell death & disease 2021 - GeneRIF: Loss of EHF facilitates the development of treatment-induced neuroendocrine prostate cancer.
- EHF enhances malignancy by modulating AKT and MAPK/ERK signaling in non‑small cell lung cancer cells.
Gao, Oncology reports 2021 - GeneRIF: EHF enhances malignancy by modulating AKT and MAPK/ERK signaling in nonsmall cell lung cancer cells.
- Activation of EHF via STAT3 phosphorylation by LMP2A in Epstein-Barr virus-positive gastric cancer.
Li, Cancer science 2021 - GeneRIF: Activation of EHF via STAT3 phosphorylation by LMP2A in Epstein-Barr virus-positive gastric cancer.
- Ese-3 Inhibits the Proliferation, Migration, and Invasion of HaCaT Cells by Downregulating PSIP1 and NUCKS1.
Zhang, Annals of clinical and laboratory science 2021 (PubMed)- GeneRIF: Ese-3 Inhibits the Proliferation, Migration, and Invasion of HaCaT Cells by Downregulating PSIP1 and NUCKS1.
- Pancreatic cancer cell-derived microRNA-155-5p-containing extracellular vesicles promote immune evasion by triggering EHF-dependent activation of Akt/NF-κB signaling pathway.
Wang, International immunopharmacology 2021 (PubMed)- GeneRIF: Pancreatic cancer cell-derived microRNA-155-5p-containing extracellular vesicles promote immune evasion by triggering EHF-dependent activation of Akt/NF-kappaB signaling pathway.
- Expression and prognostic significance of epithelial tissue-specific transcription factor ESE3 in hepatocellular carcinoma.
Lyu, International journal of clinical oncology 2020 (PubMed)- GeneRIF: Expression and prognostic significance of epithelial tissue-specific transcription factor ESE3 in hepatocellular carcinoma.
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- Quantitative proteomic analysis identifies proteins and pathways related to neuronal development in differentiated SH-SY5Y neuroblastoma cells
Murillo, EuPA open proteomics 2017 - “...O95343 Homeobox protein SIX3 (SIX3) 0.62 2.16E-04 Q71RC2 La-related protein 4 (LARP4) 0.63 3.70E-02 Ser583(0.63) Q9NZC4 ETS homologous factor (EHF) 0.64 1.29E-02 P20839 Inosine-5-monophosphate dehydrogenase 1 (IMPDH1) 0.64 1.13E-03 Q08211 ATP-dependent RNA helicase A (DHX9) 0.64 2.16E-02 Ser87(0.64) P53804 E3 ubiquitin-protein ligase TTC3 (TTC3) 0.65 2.43E-02...”
P97360 Transcription factor ETV6 from Mus musculus
40% identity, 17% coverage
LOC107451717, XP_015923392 SAM pointed domain-containing Ets transcription factor from Parasteatoda tepidariorum
52% identity, 19% coverage
- Reconstruction of the Global Polarity of an Early Spider Embryo by Single-Cell and Single-Nucleus Transcriptome Analysis
Akiyama-Oda, Frontiers in cell and developmental biology 2022 - “...in dendrograms with the heatmap showing normalized counts. Identification of CM-Cell Markers The expression of LOC107451717 ( Pt-Ets4 ) ( Pechmann et al., 2017 ) was used to identify a putative CM cell (#614005), and genes that showed specific expression at this cell were searched based...”
- “...Known markers for this cell type include Pt-dpp (LOC107442925), Pt-fascin (singed) (At_eW_022_P10, LOC107440147), and Pt-ets4 (LOC107451717) ( Pechmann et al., 2017 ) ( Figure 5A ). To examine the comprehensiveness and practical use of our single-cell transcriptome data, we searched for additional CM-cell marker genes. Highly...”
- A SoxB gene acts as an anterior gap gene and regulates posterior segment addition in a spider
Paese, eLife 2018 - “...Gene ( P. tepidariorum ) engrailed NA AB125741 Gene ( P. tepidariorum ) ets4 NA XP_015923392 Gene ( P. tepidariorum ) forkhead NA AB096073 Gene ( P. tepidariorum ) hairy NA AB125743 Gene ( P. tepidariorum ) hedgehog NA AB125742 Gene ( P. tepidariorum ) labial...”
XP_016874479 transcription factor ETV6 isoform X2 from Homo sapiens
40% identity, 20% coverage
- ETV6::ACSL6 translocation-driven super-enhancer activation leads to eosinophilia in acute lymphoblastic leukemia through IL-3 overexpression.
Xu, Haematologica 2024 - GeneRIF: ETV6::ACSL6 translocation-driven super-enhancer activation leads to eosinophilia in acute lymphoblastic leukemia through IL-3 overexpression.
- Characteristics and literature review of ETV6::ABL1 fusion gene-positive acute myeloid leukemia.
Xue, International journal of hematology 2024 (PubMed)- GeneRIF: Characteristics and literature review of ETV6::ABL1 fusion gene-positive acute myeloid leukemia.
- ETV3 and ETV6 enable monocyte differentiation into dendritic cells by repressing macrophage fate commitment.
Villar, Nature immunology 2023 - GeneRIF: ETV3 and ETV6 enable monocyte differentiation into dendritic cells by repressing macrophage fate commitment.
- Fishing for ETV6/RUNX1 fusion and MLL gene rearrangements and their additional abnormalities in childhood acute lymphoblastic leukemia patients of Kashmir.
Mohiuddin, Gene 2023 (PubMed)- GeneRIF: Fishing for ETV6/RUNX1 fusion and MLL gene rearrangements and their additional abnormalities in childhood acute lymphoblastic leukemia patients of Kashmir.
- Hereditary platelet disorders associated with germ line variants in RUNX1, ETV6, and ANKRD26.
Homan, Blood 2023 - GeneRIF: Hereditary platelet disorders associated with germ line variants in RUNX1, ETV6, and ANKRD26.
- The ETS transcription factor ETV6 constrains the transcriptional activity of EWS-FLI to promote Ewing sarcoma.
Lu, Nature cell biology 2023 - GeneRIF: The ETS transcription factor ETV6 constrains the transcriptional activity of EWS-FLI to promote Ewing sarcoma.
- Functional damaging germline variants in ETV6, IKZF1, PAX5 and RUNX1 predisposing to B-cell precursor acute lymphoblastic leukemia.
Wagener, European journal of medical genetics 2023 (PubMed)- GeneRIF: Functional damaging germline variants in ETV6, IKZF1, PAX5 and RUNX1 predisposing to B-cell precursor acute lymphoblastic leukemia.
- Description of an Institutional Cohort of Myeloid Neoplasms Carrying ETV6-Locus Deletions or ETV6 Rearrangements.
Papadopoulou, Acta haematologica 2023 - GeneRIF: Description of an Institutional Cohort of Myeloid Neoplasms Carrying ETV6-Locus Deletions or ETV6 Rearrangements.
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ETV6_HUMAN / P41212 Transcription factor ETV6; ETS translocation variant 6; ETS-related protein Tel1; Tel from Homo sapiens (Human) (see 14 papers)
40% identity, 18% coverage
- function: Transcriptional repressor; binds to the DNA sequence 5'- CCGGAAGT-3'. Plays a role in hematopoiesis and malignant transformation.
subunit: Can form homodimers or heterodimers with TEL2 or FLI1. Interacts with L3MBTL1 and HDAC9. - Filamin C dimerisation is regulated by HSPB7
Wang, Nature communications 2025 - Cardiac stress leads to regulation of Filamin C dimerisation via an ancient phosphorylation-modulated interaction with HSPB7
Wang, 2024 - Revisiting Homochiral versus Heterochiral Interactions through a Long Detective Story of a Useful Azobis-Nitrile and Puzzling Racemate
García, Crystal growth & design 2023 (no snippet) - Increasing the bulk of the 1TEL-target linker and retaining the 10×His tag in a 1TEL-CMG2-vWa construct improves crystal order and diffraction limits.
Gajjar, Acta crystallographica. Section D, Structural biology 2023 - “...ETV6 (ETS variant transcription factor 6, also known as translocation ETS leukaemia protein, TEL; UniProt P41212). The pH-sensitive variant of this SAM domain is hereafter referred to as 1TEL. An alanine linker was placed between the two domains and substitutions relative to the wild-type proteins included...”
- Fusion crystallization reveals the behavior of both the 1TEL crystallization chaperone and the TNK1 UBA domain.
Nawarathnage, Structure (London, England : 1993) 2023 - Fusion crystallization reveals the behavior of both the 1TEL crystallization chaperone and the TNK1 UBA domain.
Nawarathnage, bioRxiv : the preprint server for biology 2023 - “...Q13470) were inserted after residues 48123 of human ETV6/TEL (the sterile alpha motif/SAM domain, Uniprot P41212), both of which were inserted downstream of the 10xHis-SUMO domain in the pET42-SUMO vector 68 . Residues 122123 of the TELSAM domain were substituted with glycines to impart flexibility to...”
- High-Resolution Crystal Structure of Muscle Phosphoglycerate Mutase Provides Insight into Its Nuclear Import and Role
Wiśniewski, International journal of molecular sciences 2022 - “...This is the first structure of the muscle isoenzyme of PGAM. PGAM2 crystallized in the P41212 space group, with one protein chain in the asymmetric unit ( Figure 1 A). The quality of the electron density is excellent ( Figure 1 D), except for the C-terminal...”
- Crystals of TELSAM-target protein fusions that exhibit minimal crystal contacts and lack direct inter-TELSAM contacts.
Nawarathnage, Open biology 2022 - “...(the SAM domain) of human ETS variant transcription factor 6 (also known as TEL, Uniprot: P41212) was designed and cloned as described above. The TEL SAM domain (TELSAM) arginine 49 was mutated to alanine to alleviate a potential clash with the vWa domain. Other mutations in...”
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NP_001290031 transcription factor ETV6 isoform 2 from Mus musculus
40% identity, 19% coverage
- ETV3 and ETV6 enable monocyte differentiation into dendritic cells by repressing macrophage fate commitment.
Villar, Nature immunology 2023 - GeneRIF: ETV3 and ETV6 enable monocyte differentiation into dendritic cells by repressing macrophage fate commitment.
- ETV6 represses inflammatory response genes and regulates HSPC function during stress hematopoiesis in mice.
Bloom, Blood advances 2023 - GeneRIF: ETV6 represses inflammatory response genes and regulates HSPC function during stress hematopoiesis in mice.
- RNA binding protein IGF2BP1 synergizes with ETV6-RUNX1 to drive oncogenic signaling in B-cell Acute Lymphoblastic Leukemia.
Sharma, Journal of experimental & clinical cancer research : CR 2023 - GeneRIF: RNA binding protein IGF2BP1 synergizes with ETV6-RUNX1 to drive oncogenic signaling in B-cell Acute Lymphoblastic Leukemia.
- Transcription factor Etv6 regulates functional differentiation of cross-presenting classical dendritic cells.
Lau, The Journal of experimental medicine 2018 - GeneRIF: Etv6 optimizes the resolution of cDC1 and pDC expression programs and the functional fitness of cDC1, thereby facilitating T cell cross-priming and tumor-specific responses.
- Molecular role of the PAX5-ETV6 oncoprotein in promoting B-cell acute lymphoblastic leukemia.
Smeenk, The EMBO journal 2017 - GeneRIF: Together with similar observations made in human PAX5-ETV6(+) B-ALLs, these data identified PAX5-ETV6 fusion as a potent oncoprotein that drives B-cell leukemia development.
- Cooperation of ETV6/RUNX1 and BCL2 enhances immunoglobulin production and accelerates glomerulonephritis in transgenic mice.
Bauer, Oncotarget 2016 - GeneRIF: Study reveals a previously unrecognized synergism between ETV6/RUNX1 and BCL2 impacting on malignant disease and autoimmunity.
- Autoinhibition of ETV6 DNA Binding Is Established by the Stability of Its Inhibitory Helix.
De, Journal of molecular biology 2016 - GeneRIF: ETV6 DNA binding inhibition is established by the stability of its inhibitory helix
- Somatic drivers of B-ALL in a model of ETV6-RUNX1; Pax5(+/-) leukemia.
van, BMC cancer 2015 - GeneRIF: Studied the combination of Etv6-RUNX1 and Pax5(+/-) alleles, they generated a transplantable B220 + CD19+ B-ALL with a significant disease incidence; RNA-seq analysis showed a gene expression pattern consistent with arrest at the pre-B stage.
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LOC104916915 ETS domain-containing transcription factor ERF-like from Meleagris gallopavo
57% identity, 67% coverage
8e67F / P97360 Etv6 h396y variant bound to DNA containing the sequence ggat
42% identity, 86% coverage
ETS7_CAEEL / O01519 ETS domain-containing protein ets-7; ETS class transcription factor ets-7 from Caenorhabditis elegans (see paper)
42% identity, 38% coverage
- function: Probable transcription factor (By similarity). Involved in responses to oxidative stress (PubMed:27514077).
ETS4_CAEEL / A8WFJ9 Transcription factor ets-4 from Caenorhabditis elegans (see 3 papers)
49% identity, 19% coverage
- function: Transcription factor which binds to 5'-GGAA/T-3' DNA consensus sequences (PubMed:20862312, PubMed:26484536). Both positively and negatively regulates the expression of target genes (PubMed:20862312). Plays a role in the regulation of adult lifespan, which may in part be through modulation of daf-16 activity (PubMed:20862312). Regulates the expression of genes such as svh-2 in response to axon injury and in addition, may function downstream of the cAMP signaling pathway to promote axon regeneration (PubMed:26484536). Regulates the expression of lipid metabolism genes and may also control the expression of the RNA-binding protein rege-1 which too has been implicated in the control of fat accumulation (PubMed:27746047).
subunit: May interact with cebp-1.
disruption phenotype: Delayed larval development and increased lifespan, but overall resulting animals have normal morphology and fecundity (PubMed:20862312). Reduced egg-laying rate, but older hermaphrodites produce more progeny (PubMed:20862312). Both decreased expression of genes, such as the lipoprotein vit-5, which is related to life span regulation, and increased expression of genes such as lys-7, which is a lysosomal protein (PubMed:20862312). Reduced expression of genes such as svh-2 in response to axon injury and as a result, there is reduced axon regeneration of D-type motor neurons (PubMed:26484536). RNAi-mediated knockdown results in reduced expression of the RNA- binding protein rege-1 (PubMed:27746047).
LOC552797 ETS-related transcription factor Elf-5 from Apis mellifera
41% identity, 27% coverage
- A postmeiotically bifurcated roadmap of honeybee spermatogenesis marked by phylogenetically restricted genes
Yin, PLoS genetics 2023 - “...were excluded from this analysis. (G) The consensus recognition motif of the two ETS-domain TFs, LOC552797 and LOC100576369, on the target genes in the sSPT network. In the sSPT network, 5 out of the 139 active TFs had target genes with relatively high HRG/pre-HRG ratios (outside...”
- “...TF, orthologous to Dmel \ FoxP ), LOC411104 (a Homeobox TF, Dmel \ scro ), LOC552797 (an ETS-domain TF, Dmel \ edl ), LOC100576369 (an ETS-domain TF, Dmel \ aop ), and LOC100577909 (predicted as high mobility group protein I). Among them, LOC552797 and LOC100576369 ,...”
LOC105674532 ETS homologous factor-like from Linepithema humile
41% identity, 28% coverage
- Social environment affects the transcriptomic response to bacteria in ant queens
Viljakainen, Ecology and evolution 2018 - “...LOC105677852 Uncharacterized LOC105677852 (LOC105677852) 1.05 3.56E06 2.10E03 LOC105677615 Alphatocopherol transfer proteinlike (LOC105677615) 1.08 3.51E04 7.94E02 LOC105674532 ETS homologous factorlike (LOC105674532) 1.10 3.64E08 9.11E05 LOC105677500 Glucosylceramidaselike (LOC105677500) 1.15 2.75E04 7.60E02 LOC105671381 Uncharacterized LOC105671381 (LOC105671381) 1.16 8.44E06 4.69E03 LOC105668572 Uncharacterized LOC105668572 (LOC105668572) 1.18 2.42E07 2.69E04 LOC105673352 Sodiumcoupled neutral...”
- “...synthase 2, mitochondrial (LOC105668941) 0.86 3.49E05 6.23E03 LOC105669588 Apoptosisinducing factor 3 (LOC105669588) 0.85 2.78E07 1.03E04 LOC105674532 ETS homologous factorlike (LOC105674532) 0.84 3.01E04 4.05E02 LOC105678679 AN1type zinc finger protein 2Alike (LOC105678679) 0.84 5.66E04 6.38E02 LOC105677494 Annexin B9 (LOC105677494) 0.83 7.92E06 1.97E03 LOC105670266 Sodium/potassium/calcium exchanger 3like (LOC105670266) 0.81...”
NP_001193968 transcription factor ETV7 isoform 6 from Homo sapiens
45% identity, 29% coverage
XP_005216443 ETS-related transcription factor Elf-5 isoform X1 from Bos taurus
Q58DT0 ETS-related transcription factor Elf-5 from Bos taurus
42% identity, 31% coverage
ELF5_MOUSE / Q8VDK3 ETS-related transcription factor Elf-5; E74-like factor 5 from Mus musculus (Mouse) (see 2 papers)
42% identity, 31% coverage
- function: Transcriptionally activator that may play a role in regulating the later stages of keratinocytes terminal differentiation (By similarity). Binds to DNA sequences containing the consensus nucleotide core sequence GGA[AT]. Transcriptionally activates the TK promoter.
ELF5_HUMAN / Q9UKW6 ETS-related transcription factor Elf-5; E74-like factor 5; Epithelium-restricted ESE-1-related Ets factor; Epithelium-specific Ets transcription factor 2; ESE-2 from Homo sapiens (Human) (see 2 papers)
42% identity, 29% coverage
- function: Transcriptionally activator that may play a role in regulating the later stages of keratinocytes terminal differentiation.
function: Isoform 2 binds to DNA sequences containing the consensus nucleotide core sequence GGA[AT]. Transcriptionally activates SPRR2A and the parotid gland-specific PSP promoters.
XP_016872797 ETS-related transcription factor Elf-5 isoform X1 from Homo sapiens
42% identity, 33% coverage
- ELF5 is a potential respiratory epithelial cell-specific risk gene for severe COVID-19.
Pietzner, Nature communications 2022 - GeneRIF: ELF5 is a potential respiratory epithelial cell-specific risk gene for severe COVID-19.
- Breast-Specific Molecular Clocks Comprised of ELF5 Expression and Promoter Methylation Identify Individuals Susceptible to Cancer Initiation.
Miyano, Cancer prevention research (Philadelphia, Pa.) 2021 - GeneRIF: Breast-Specific Molecular Clocks Comprised of ELF5 Expression and Promoter Methylation Identify Individuals Susceptible to Cancer Initiation.
- ELF5 inhibits the proliferation and invasion of breast cancer cells by regulating CD24.
Qu, Molecular biology reports 2021 (PubMed)- GeneRIF: ELF5 inhibits the proliferation and invasion of breast cancer cells by regulating CD24.
- ELF5 modulates the estrogen receptor cistrome in breast cancer.
Piggin, PLoS genetics 2020 - GeneRIF: ELF5 alters ER-driven gene expression via ER/FOXA1 cistrome and by modulating the expression of members of the ER transcriptional complex in breast cancer cells.
- WWOX regulates the Elf5/Snail1 pathway to affect epithelial-mesenchymal transition of ovarian carcinoma cells in vitro.
Xu, European review for medical and pharmacological sciences 2020 (PubMed)- GeneRIF: WWOX regulates the Elf5/Snail1 pathway to affect epithelial-mesenchymal transition of ovarian carcinoma cells in vitro.
- Loss of ELF5-FBXW7 stabilizes IFNGR1 to promote the growth and metastasis of triple-negative breast cancer through interferon-γ signalling.
Singh, Nature cell biology 2020 - GeneRIF: A negative correlation between ELF5, FBXW7 and IFNGR1 expression in the tumours of patients with TNBC.
- Overexpression of E74-Like Factor 5 (ELF5) Inhibits Migration and Invasion of Ovarian Cancer Cells.
Zhang, Medical science monitor : international medical journal of experimental and clinical research 2019 - GeneRIF: Authors found that expression of ELF5 was obviously decreased in ovarian cancer cell lines. The cells viability, invasion and metastasis were inhibited by overexpression ELF5.
- Coordinate regulation of ELF5 and EHF at the chr11p13 CF modifier region.
Swahn, Journal of cellular and molecular medicine 2019 - GeneRIF: Coordinate regulation of ELF5 and EHF at the chr11p13 CF modifier region.
- More
Bm1_27305 Ets-domain containing protein from Brugia malayi
40% identity, 25% coverage
- A novel member of the let-7 microRNA family is associated with developmental transitions in filarial nematode parasites
Winter, BMC genomics 2015 - “...2 and Additional file 6 ). Three of these genes were chosen for further study; Bm1_27305 (encoding an ETS-domain containing protein), Bm1_05425 (encoding a Zinc finger in N-recognin family protein) and Bm1_25620 (which encodes a putative high mobility group, HMG, protein). For Bm1_27305 and Bm1_05425 the...”
- “...represented bona fide miR-5364 targets was provided by searching for sites in the orthologs of Bm1_27305, Bm1_05425 and Bm1_25620 in the clade III parasitic nematodes L. loa , W. bancrofti and L. sigmodontis (see Additional file 7 ). 3 RACE was performed for the three proposed...”
NP_001036902 transcription factor Ets from Bombyx mori
35% identity, 21% coverage
SPI1_RAT / Q6BDS1 Transcription factor PU.1 from Rattus norvegicus (Rat) (see paper)
42% identity, 30% coverage
- function: Pioneer transcription factor, which controls hematopoietic cell fate by decompacting stem cell heterochromatin and allowing other transcription factors to enter otherwise inaccessible genomic sites. Once in open chromatin, can directly control gene expression by binding genetic regulatory elements and can also more broadly influence transcription by recruiting transcription factors, such as interferon regulatory factors (IRFs), to otherwise inaccessible genomic regions (By similarity). Transcriptionally activates genes important for myeloid and lymphoid lineages, such as CSF1R or FCER1A (PubMed:15304324). Transcriptional activation from certain promoters, possibly containing low affinity binding sites, is achieved cooperatively with other transcription factors. FCER1A transactivation is achieved in cooperation with GATA1 (PubMed:15304324). May be particularly important for the pro- to pre-B cell transition. Binds (via the ETS domain) onto the purine-rich DNA core sequence 5'-GAGGAA- 3', also known as the PU-box (By similarity). In vitro can bind RNA and interfere with pre-mRNA splicing (By similarity).
subunit: Binds DNA as a monomer. Can form homomers (By similarity). Directly interacts with CEBPD/NF-IL6-beta; this interaction does not affect DNA-binding properties of each partner. Interacts with NONO/p54(nrb) (By similarity). Interacts with RUNX1/AML1. Interacts with GFI1; the interaction represses SPI1 transcriptional activity, hence blocks SPI1-induced macrophage differentiation of myeloid progenitor cells. Interacts with CEBPE. Interacts with IRF4/Pip and IRF8. Interacts with JUN. Interacts with RB1. Interacts with TBP (By similarity).
XP_006234594 transcription factor PU.1 isoform X1 from Rattus norvegicus
42% identity, 29% coverage
- PU.1 interaction with p50 promotes microglial-mediated inflammation in secondary spinal cord injury in SCI rats.
Yu, The International journal of neuroscience 2023 (PubMed)- GeneRIF: PU.1 interaction with p50 promotes microglial-mediated inflammation in secondary spinal cord injury in SCI rats.
- Salmonella pathogenicity island 1 knockdown confers protection against myocardial fibrosis and inflammation in uremic cardiomyopathy via down-regulation of S100 Calcium Binding Protein A8/A9 transcription.
Cai, Renal failure 2022 - GeneRIF: Salmonella pathogenicity island 1 knockdown confers protection against myocardial fibrosis and inflammation in uremic cardiomyopathy via down-regulation of S100 Calcium Binding Protein A8/A9 transcription.
- Transcription factors Tp73, Cebpd, Pax6, and Spi1 rather than DNA methylation regulate chronic transcriptomics changes after experimental traumatic brain injury.
Lipponen, Acta neuropathologica communications 2018 - GeneRIF: Four upregulated transcription factors Pax6, Tp73, Cebpd, and Spi1, appeared as potent regulators of chronic post-traumatic brain injury (TBI) gene expression. They regulate molecular networks contributing to post-injury secondary damage, including apoptosis and inflammation, strengthening the feasibility of therapeutically targeting these molecular networks even after the acute post-TBI period.
- Nrf2 regulates PU.1 expression and activity in the alveolar macrophage.
Staitieh, American journal of physiology. Lung cellular and molecular physiology 2015 - GeneRIF: Nrf2 regulates the expression and activity of PU.1 and that antioxidant response and immune activation are coordinately regulated within the AM.
- PU.1-silenced dendritic cells prolong allograft survival in rats receiving intestinal transplantation.
Xu, World journal of gastroenterology 2013 - GeneRIF: PU.1-silenced semi-mature dendritic cells induced partial immune tolerance both in vitro and in vivo, which could be used as a new strategy to promote intestinal transplantation tolerance.
- Analysis of PU.1/ICSBP (IRF-8) complex formation with various PU.1 mutants: molecular cloning of rat Icsbp (Irf-8) cDNA.
Nakano, Immunogenetics 2005 (PubMed)- GeneRIF: interaction of mutants with IRF-8
XP_005660978 transcription factor PU.1 isoform X1 from Sus scrofa
42% identity, 30% coverage
SPI1_MOUSE / P17433 Transcription factor PU.1; 31 kDa-transforming protein; SFFV proviral integration 1 protein from Mus musculus (Mouse) (see 7 papers)
42% identity, 29% coverage
- function: Pioneer transcription factor, which controls hematopoietic cell fate by decompacting stem cell heterochromatin and allowing other transcription factors to enter otherwise inaccessible genomic sites (PubMed:8079170). Once in open chromatin, can directly control gene expression by binding genetic regulatory elements and can also more broadly influence transcription by recruiting transcription factors, such as interferon regulatory factors (IRFs), to otherwise inaccessible genomic regions (By similarity). Transcriptionally activates genes important for myeloid and lymphoid lineages, such as CSF1R (By similarity). Transcriptional activation from certain promoters, possibly containing low affinity binding sites, is achieved cooperatively with other transcription factors. FCER1A transactivation is achieved in cooperation with GATA1 (By similarity). May be particularly important for the pro- to pre-B cell transition (PubMed:8079170). Binds (via the ETS domain) onto the purine-rich DNA core sequence 5'-GAGGAA-3', also known as the PU-box (PubMed:2180582). In vitro can bind RNA and interfere with pre-mRNA splicing (PubMed:8626664).
subunit: Binds DNA as a monomer. Can form homomers (By similarity). Directly interacts with CEBPD/NF-IL6-beta; this interaction does not affect DNA-binding properties of each partner (PubMed:7594592). Interacts with NONO/p54(nrb) (PubMed:8626664). Interacts with RUNX1/AML1 (By similarity). Interacts with GFI1; the interaction represses SPI1 transcriptional activity, hence blocks SPI1-induced macrophage differentiation of myeloid progenitor cells (PubMed:17197705). Interacts with CEBPE (By similarity). Interacts with IRF4/Pip and IRF8 (By similarity). Interacts with JUN (By similarity). Interacts with RB1 (By similarity). Interacts with TBP (By similarity).
disruption phenotype: Knockout embryos die at a late gestational stage, with no viable embryo after day 18 of gestation. Mutant embryos produce normal numbers of megakaryocytes and erythroid progenitors, but some show an impairment of erythroblast maturation. They exhibit a multilineage defect in the generation of progenitors for B and T lymphocytes, monocytes and granulocytes. - Proteomic analysis reveals semaglutide impacts lipogenic protein expression in epididymal adipose tissue of obese mice.
Zhu, Frontiers in endocrinology 2023 - “...O35904 A3KGF7 Q9EP53 up Acute myeloid leukemia 6 0.003441545 0.13284056 0.15384615 P42232 P31938 P10810 P31750 P17433 O35904 up Cell adhesion molecules 7 0.003512205 0.13284056 0.13461539 P01899 P06339 P13597 P15702 P06332 Q9Z261 P27573 up Primary immunodeficiency 3 0.003983193 0.13284056 0.33333333 P36371 P21958 P06332 up Natural killer cell...”
- “...leukemia virus 1 infection 10 0.005680549 0.150034667 0.09803922 P01899 P42232 P06339 P31938 P13597 P31750 P27931 P17433 P06332 O35904 up Fc gamma R-mediated phagocytosis 8 0.006148962 0.150034667 0.11111111 Q8CIH5 Q05144 P08101 P31938 P28667 P31750 Q7TQF7 O35904 up ECM-receptor interaction 10 3.35E-05 0.008284126 0.2173913 Q05793 Q61292 P97927 P02469...”
- MEF2C and EBF1 Co-regulate B Cell-Specific Transcription.
Kong, PLoS genetics 2016 - “...transcription factors to direct B cell development. Mice lacking E12, PAX5 (UniProt Q02650), PU.1 (UniProt P17433), or EBF1 have defects in B cell development or reduction of early lymphoid/myeloid progenitors [ 21 ] [ 22 ] [ 23 ] [ 24 ] [ 25 ]. Therefore,...”
- spib is required for primitive myeloid development in Xenopus.
Costa, Blood 2008 - “...Xl spiba BC046671, Xl spibb BC130210, Xt spib IMAGE 7023083, Hs spi1 P17947, Mm spi1 P17433, Gg spi1 NP_990354, Xt spi1 BC098077, and Dr spi1 CAD58735 (outgroup NP_001008139 and P14921). Using WMISH, we determined the expression pattern of Xenopus laevis spib paralogs and Xenopus tropicalis spib...”
NP_001376298 transcription factor PU.1 isoform 1 from Gallus gallus
40% identity, 22% coverage
- PU.1 Regulates Cathepsin S Expression in Large Yellow Croaker (Larimichthys crocea) Macrophages
Zhang, Frontiers in immunology 2021 - “...H sapiens PU.1, NP_001074016; M. musculus PU.1, NP_001365827; R. norvegicus PU.1, NP_001005892; G gallus PU.1, NP_001376298; X. tropicalis PU.1, NP_001139455; D rerio PU.1, NP_001315297; O. mykiss PU.1, NP_001117985; L. crocea PU.1a, XM_010748147; L. crocea PU.1b, XM_010748147; H sapiens SPI-B, NP_001230927; M. musculus SPI-B, NP_063919; R. norvegicus...”
XP_021049567 transcription factor PU.1 from Mus pahari
42% identity, 30% coverage
SPI1_HUMAN / P17947 Transcription factor PU.1; 31 kDa-transforming protein from Homo sapiens (Human) (see 7 papers)
NP_003111 transcription factor PU.1 isoform 2 from Homo sapiens
42% identity, 30% coverage
- function: Pioneer transcription factor, which controls hematopoietic cell fate by decompacting stem cell heterochromatin and allowing other transcription factors to enter otherwise inaccessible genomic sites. Once in open chromatin, can directly control gene expression by binding genetic regulatory elements and can also more broadly influence transcription by recruiting transcription factors, such as interferon regulatory factors (IRFs), to otherwise inaccessible genomic regions (PubMed:23658224, PubMed:33951726). Transcriptionally activates genes important for myeloid and lymphoid lineages, such as CSF1R (By similarity). Transcriptional activation from certain promoters, possibly containing low affinity binding sites, is achieved cooperatively with other transcription factors. FCER1A transactivation is achieved in cooperation with GATA1 (By similarity). May be particularly important for the pro- to pre-B cell transition (PubMed:33951726). Binds (via the ETS domain) onto the purine-rich DNA core sequence 5'-GAGGAA-3', also known as the PU-box (PubMed:33951726). In vitro can bind RNA and interfere with pre-mRNA splicing (By similarity).
subunit: Binds DNA as a monomer. Can form homomers (PubMed:10196196). Directly interacts with CEBPD/NF-IL6-beta; this interaction does not affect DNA-binding properties of each partner (By similarity). Interacts with NONO/p54(nrb) (By similarity). Interacts with RUNX1/AML1 (PubMed:10207087). Interacts with GFI1; the interaction represses SPI1 transcriptional activity, hence blocks SPI1-induced macrophage differentiation of myeloid progenitor cells (PubMed:17197705). Interacts with CEBPE (PubMed:26019275). Interacts with IRF4/Pip and IRF8 (PubMed:10196196, PubMed:33951726). Interacts with JUN (PubMed:10196196). Interacts with RB1 (PubMed:10196196). Interacts with TBP (PubMed:10196196). - Role of LINC00240 on T-helper 9 differentiation in allergic rhinitis through influencing DNMT1-dependent methylation of PU.1.
Liu, Immunologic research 2024 (PubMed)- GeneRIF: Role of LINC00240 on T-helper 9 differentiation in allergic rhinitis through influencing DNMT1-dependent methylation of PU.1.
- Transcriptional regulation of the HIV-1 inhibitory factor human mannose receptor 1 by the myeloid-specific transcription factor PU.1.
Mallorson, Journal of virology 2024 - GeneRIF: Transcriptional regulation of the HIV-1 inhibitory factor human mannose receptor 1 by the myeloid-specific transcription factor PU.1.
- HIV-1 Vpr combats the PU.1-driven antiviral response in primary human macrophages.
Virgilio, Nature communications 2024 - GeneRIF: HIV-1 Vpr combats the PU.1-driven antiviral response in primary human macrophages.
- SPI1-mediated transcriptional activation of CEP55 promotes the malignant growth of triple-negative breast cancer and M2 macrophage polarization.
Liu, Pathology, research and practice 2024 (PubMed)- GeneRIF: SPI1-mediated transcriptional activation of CEP55 promotes the malignant growth of triple-negative breast cancer and M2 macrophage polarization.
- PU.1 negatively regulates tumorigenesis in non-small-cell lung cancer.
Liu, Medical oncology (Northwood, London, England) 2023 (PubMed)- GeneRIF: PU.1 negatively regulates tumorigenesis in non-small-cell lung cancer.
- LINC01004-SPI1 axis-activated SIGLEC9 in tumor-associated macrophages induces radioresistance and the formation of immunosuppressive tumor microenvironment in esophageal squamous cell carcinoma.
Zhao, Cancer immunology, immunotherapy : CII 2023 - GeneRIF: LINC01004-SPI1 axis-activated SIGLEC9 in tumor-associated macrophages induces radioresistance and the formation of immunosuppressive tumor microenvironment in esophageal squamous cell carcinoma.
- SPI1 Mediates N-Myristoyltransferase 1 to Advance Gastric Cancer Progression via PI3K/AKT/mTOR Pathway.
Qiu, Canadian journal of gastroenterology & hepatology 2023 - GeneRIF: SPI1 Mediates N-Myristoyltransferase 1 to Advance Gastric Cancer Progression via PI3K/AKT/mTOR Pathway.
- SPI1-mediated autophagy of peripheral blood monocyte cells as a mechanism for sepsis based on single-cell RNA sequencing.
Xie, International immunopharmacology 2023 (PubMed)- GeneRIF: SPI1-mediated autophagy of peripheral blood monocyte cells as a mechanism for sepsis based on single-cell RNA sequencing.
- More
- Multi-Target Effect of Aloeresin-A against Bacterial and Host Inflammatory Targets Benefits Contact Lens-Related Keratitis: A Multi-Omics and Quantum Chemical Investigation
Roshni, Molecules (Basel, Switzerland) 2023 - “...associated with the inflammatory processes. Hence, the 3D structure of host target SPI1 (Accession ID: P17947) was retrieved from the Alpha-Fold database for the subsequent molecular docking studies. 2.4. Inhibitory Potential of A. vera Phytochemicals against Keratitis Targets The A. vera -derived phytochemicals ( n =...”
- Integrated analysis of microbe-host interactions in Crohn's disease reveals potential mechanisms of microbial proteins on host gene expression.
Sudhakar, iScience 2022 - “...factors STAT3 (UniProt: P40763), TP53 (UniProt: P04637), ESR1 (UniProt: P03372), STAT1 (UniProt: P42224), SPI1 (UniProt: P17947), SMAD3 (UniProt: P84022), and MYC (UniProt: P01106)( Table 1) in addition to signaling proteins represented by SOCS3 (UniProt: O14543), SRC (UniProt: P12931), NCOA1 (UniProt: Q15788), CTNNB1 (UniProt: P35222), and PRKACA...”
- The EBV Latent Antigen 3C Inhibits Apoptosis through Targeted Regulation of Interferon Regulatory Factors 4 and 8
Banerjee, PLoS pathogens 2013 - “...IRF8 protein (Homo sapiens)-NCBI Reference Sequence: NP_002154.1, EBNA3C protein- UniProtKB/Swiss-Prot: P03204.1, Spi-1 protein- UniProtKB/Swiss-Prot: SPI1_HUMAN, P17947, Spi-B protein- UniProtKB/Swiss-Prot: SPIB_HUMAN, Q01892. Supporting Information Figure S1 Quantitation of Irf4 and Irf8 mRNA expression in EBV positive and EBNA3C expressing cells. Total RNA was isolated from BAC-GFP EBV...”
- Reduced dosage of ERF causes complex craniosynostosis in humans and mice and links ERK1/2 signaling to regulation of osteogenesis.
Twigg, Nature genetics 2013 - “...Erf mRNA sequence: NCBI reference sequence NM_010155.3. Human ETS DNA-binding proteins (Swissprot): ERF, P50548; SPI1, P17947; ETV6, P41212; ELF3; P78545; ELF1, P32519; SPDEF, O95238; ETV4, P43268; ELK1, P19419; ETS1, P14921; ETV2, O00321; ERG, P11308; GABP, Q06546. Erf ChIP-Seq data: GSE42936 (GEO). References 1 Plotnikov A Zehorai...”
- Use of biotinylated plasmid DNA as a surrogate for HSV DNA to identify proteins that repress or activate viral gene expression
Mallon, Proceedings of the National Academy of Sciences of the United States of America 2012 - “...binding proteins Q6FI13 HIST2H2AA3 Q15233 NONO Q9P0M6 H2AFY P17947 SPI1 Q86WZ6 ZNF227 Q9Y6Y1 CAMTA1 Q9UIF9 BAZ2A Q92576 PHF3 O94986 CEP152 Q8TEK3 DOT1L RNA...”
- Acetylation Increases EWS-FLI1 DNA Binding and Transcriptional Activity.
Schlottmann, Frontiers in oncology 2012 - “...positions. Protein sequences of ETS1 (P14921), ETS2 (P15036), ETV6 (P41212), ETV7 (Q9Y603), SPIB (Q01892), SPI1 (P17947), ETV1 (P50549), ETV5 (P41161), ETV4 (P43268), ERG (P11308), FLI1 (Q01543), FEV (Q99581), and ETV2 (O00321) were aligned using UniProt, to reveal conservation of Lysine positions K240, K252, K380, and K397....”
- spib is required for primitive myeloid development in Xenopus.
Costa, Blood 2008 - “...Mm spib O35906, Xl spiba BC046671, Xl spibb BC130210, Xt spib IMAGE 7023083, Hs spi1 P17947, Mm spi1 P17433, Gg spi1 NP_990354, Xt spi1 BC098077, and Dr spi1 CAD58735 (outgroup NP_001008139 and P14921). Using WMISH, we determined the expression pattern of Xenopus laevis spib paralogs and...”
NP_001117985 Spi-1/PU.1 transcription factor from Oncorhynchus mykiss
40% identity, 30% coverage
- PU.1 Regulates Cathepsin S Expression in Large Yellow Croaker (Larimichthys crocea) Macrophages
Zhang, Frontiers in immunology 2021 - “...G gallus PU.1, NP_001376298; X. tropicalis PU.1, NP_001139455; D rerio PU.1, NP_001315297; O. mykiss PU.1, NP_001117985; L. crocea PU.1a, XM_010748147; L. crocea PU.1b, XM_010748147; H sapiens SPI-B, NP_001230927; M. musculus SPI-B, NP_063919; R. norvegicus SPI-B, NP_001019457; H sapiens SPI-C, NP_689536; M. musculus SPI-C, NP_035591; R. norvegicus...”
- Characterization and expression of the transcription factor PU.1 during LPS-induced inflammation in the rainbow trout (Oncorhynchus mykiss).
Ribas, Fish & shellfish immunology 2008 (PubMed)- GeneRIF: In trout, the PU.1 mRNA shows a tissue-specific expression pattern and is induced in vivo by LPS in muscle, liver, intestine and brain. Furthermore PU.1 is highly expressed in trout macrophages in primary culture.
XP_018082532 ETS2 repressor factor S homeolog isoform X1 from Xenopus laevis
59% identity, 9% coverage
NP_001299585 ETS domain-containing transcription factor ERF isoform 2 from Homo sapiens
59% identity, 8% coverage
- Activation of γ-globin expression by LncRNA-mediated ERF promoter hypermethylation in β-thalassemia.
Bao, Clinical epigenetics 2024 - GeneRIF: Activation of gamma-globin expression by LncRNA-mediated ERF promoter hypermethylation in beta-thalassemia.
- Loss-of-function variants in ERF are associated with a Noonan syndrome-like phenotype with or without craniosynostosis.
Dentici, European journal of human genetics : EJHG 2024 - GeneRIF: Loss-of-function variants in ERF are associated with a Noonan syndrome-like phenotype with or without craniosynostosis.
- Cognitive, Behavioural, Speech, Language and Developmental Outcomes Associated with Pathogenic Variants in the ERF Gene.
Care, The Journal of craniofacial surgery 2022 (PubMed)- GeneRIF: Cognitive, Behavioural, Speech, Language and Developmental Outcomes Associated with Pathogenic Variants in the ERF Gene.
- The CIC-ERF co-deletion underlies fusion-independent activation of ETS family member, ETV1, to drive prostate cancer progression.
Gupta, eLife 2022 - GeneRIF: The CIC-ERF co-deletion underlies fusion-independent activation of ETS family member, ETV1, to drive prostate cancer progression.
- Dissection of contiguous gene effects for deletions around ERF on chromosome 19.
Calpena, Human mutation 2021 (PubMed)- GeneRIF: Dissection of contiguous gene effects for deletions around ERF on chromosome 19.
- Deletion of ERF and CIC causes abnormal skull morphology and global developmental delay.
Singh, Cold Spring Harbor molecular case studies 2021 - GeneRIF: Deletion of ERF and CIC causes abnormal skull morphology and global developmental delay.
- A progressive and complex clinical course in two family members with ERF-related craniosynostosis: a case report.
Körberg, BMC medical genetics 2020 - GeneRIF: Here we describe a boy and his mother with different craniosynostosis patterns, but both with verified intracranial hypertension and heterozygosity for a truncating variant of ERF c.1201_1202delAA (p.Lys401Glufs*10).
- Variable pulmonary manifestations in Chitayat syndrome: Six additional affected individuals.
Suter, American journal of medical genetics. Part A 2020 (PubMed)- GeneRIF: Variable pulmonary manifestations in Chitayat syndrome: Six additional affected individuals.
- More
XP_009294897 transcription factor PU.1 from Danio rerio
42% identity, 31% coverage
XP_017176291 protein FEV isoform X1 from Mus musculus
71% identity, 22% coverage
- Neurochemically and Hodologically Distinct Ascending VGLUT3 versus Serotonin Subsystems Comprise the r2-Pet1 Median Raphe.
Senft, The Journal of neuroscience : the official journal of the Society for Neuroscience 2021 - GeneRIF: Neurochemically and Hodologically Distinct Ascending VGLUT3 versus Serotonin Subsystems Comprise the r2-Pet1 Median Raphe.
- Abnormal cell-intrinsic and network excitability in the neocortex of serotonin-deficient Pet-1 knockout mice.
Puzerey, Journal of neurophysiology 2016 - GeneRIF: Pet1 knockout leads to significant changes of cell-intrinsic excitability in cortical pyramidal cells and increase in spontaneous synaptic excitation through 5-HT3 receptors.
- Pet-1 Switches Transcriptional Targets Postnatally to Regulate Maturation of Serotonin Neuron Excitability.
Wyler, The Journal of neuroscience : the official journal of the Society for Neuroscience 2016 - GeneRIF: Pet-1 coordinates postmitotic expression of genes necessary for maturation of serotonin neuron.
- Pet-1 Controls Tetrahydrobiopterin Pathway and Slc22a3 Transporter Genes in Serotonin Neurons.
Wyler, ACS chemical neuroscience 2015 - GeneRIF: Findings indicated that while some 5-HT neurons are not absolutely dependent on Pet-1 for expression of Tph2 virtually all dorsal raphe 5-HT neurons require Pet-1 for expression of other key identity genes
- Pet-1 deficiency alters the circadian clock and its temporal organization of behavior.
Ciarleglio, PloS one 2014 - GeneRIF: Pet-1 regulation of raphe neuron serotonin phenotype contributes to the period, precision and light/dark partitioning of locomotor behavioral rhythms by the circadian clock through direct actions on the SCN clock itself and through non-clock effects
- Postnatal maintenance of the 5-Ht1a-Pet1 autoregulatory loop by serotonin in the raphe nuclei of the brainstem.
Kim, Molecular brain 2014 - GeneRIF: These results suggest a causal relationship between 5-HT1A and Pet1, and reveal a potential mechanism by which 5-HT1A-Pet1 autoregulatory loop is maintained by serotonin.
- Generation of Pet1210-Cre transgenic mouse line reveals non-serotonergic expression domains of Pet1 both in CNS and periphery.
Pelosi, PloS one 2014 - GeneRIF: Thus, Pet1(210)-Cre transgenic mouse line faithfully drives Cre-mediated recombination in all Pet1 expression domains representing a valuable tool to genetically manipulate serotonergic and non-serotonergic Pet1 cell lineages.
- Photic and nonphotic responses of the circadian clock in serotonin-deficient Pet-1 knockout mice.
Paulus, Chronobiology international 2013 (PubMed)- GeneRIF: Pet-1 knockout mice show significantly decreased phase delays of the circadian clock in response to light pulses in the early night
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8eo4F / P17947 Human pu.1 ets-domain (165-270) bound to d(aataagcggaagtggg) with di- methylated cpg sites (see paper)
42% identity, 84% coverage
D4AAH4 ETS proto-oncogene 2, transcription factor from Rattus norvegicus
38% identity, 19% coverage
- Stress alters the expression of cancer-related genes in the prostate.
Flores, BMC cancer 2017 - “...Arnt P41739 Aryl hydrocarbon receptor nuclear translocator 1.51 1.23 (ns) Transcription factor/response to hypoxia Ets2 D4AAH4 V-ets erythroblastosis virus E26 oncogene homolog 2 (avian) 1.83 1.93 Transcription factor/cell differentiation Krt14 Q6IFV1 Keratin 14 2.27 2.27 Cytoskeleton/maintenance of cell morphology Serpinb2 P29524 Serpin peptidase inhibitor, clade B...”
NP_932328 transcription factor PU.1b isoform 1 from Danio rerio
39% identity, 27% coverage
- The role of the ETS factor erg in zebrafish vasculogenesis
Ellett, Mechanisms of development 2009 - “...mm Fli1: NP_032052; mm FEV: NP_694751; mm ETS-1: NP_035938; zf Etsrp: AAY89037 and zf Spi1: NP_932328). Full-length sequence divergence analysis and domain-restricted alignments were performed with DNAstar Lasergene MegAlign. ETS DNA-binding domain restrictions were defined by comparative alignment to the DNA-binding domain of zebrafish Erg: G(254)-F(339)....”
Q6MZZ4 Uncharacterized protein DKFZp686H0575 from Homo sapiens
53% identity, 11% coverage
NP_001315297 transcription factor PU.1b isoform 2 from Danio rerio
39% identity, 30% coverage
- PU.1 Regulates Cathepsin S Expression in Large Yellow Croaker (Larimichthys crocea) Macrophages
Zhang, Frontiers in immunology 2021 - “...R. norvegicus PU.1, NP_001005892; G gallus PU.1, NP_001376298; X. tropicalis PU.1, NP_001139455; D rerio PU.1, NP_001315297; O. mykiss PU.1, NP_001117985; L. crocea PU.1a, XM_010748147; L. crocea PU.1b, XM_010748147; H sapiens SPI-B, NP_001230927; M. musculus SPI-B, NP_063919; R. norvegicus SPI-B, NP_001019457; H sapiens SPI-C, NP_689536; M. musculus...”
NP_001315298 transcription factor PU.1b isoform 3 from Danio rerio
39% identity, 30% coverage
SPIB_HUMAN / Q01892 Transcription factor Spi-B from Homo sapiens (Human) (see 6 papers)
NP_003112 transcription factor Spi-B isoform 1 from Homo sapiens
38% identity, 31% coverage
- function: Sequence specific transcriptional activator which binds to the PU-box, a purine-rich DNA sequence (5'-GAGGAA-3') that can act as a lymphoid-specific enhancer. Promotes development of plasmacytoid dendritic cells (pDCs), also known as type 2 DC precursors (pre-DC2) or natural interferon (IFN)-producing cells. These cells have the capacity to produce large amounts of interferon and block viral replication. May be required for B-cell receptor (BCR) signaling, which is necessary for normal B-cell development and antigenic stimulation.
subunit: Can form homotypic interactions (PubMed:10196196). Interacts with IRF4/Pip (PubMed:10196196). Interacts with JUN (PubMed:10196196). Interacts with TBP (PubMed:10196196). May also interact with CREBBP and EP300 (PubMed:11864910). Interacts with NONO/p54(nrb) (By similarity). - The EBV Latent Antigen 3C Inhibits Apoptosis through Targeted Regulation of Interferon Regulatory Factors 4 and 8
Banerjee, PLoS pathogens 2013 - “...Sequence: NP_002154.1, EBNA3C protein- UniProtKB/Swiss-Prot: P03204.1, Spi-1 protein- UniProtKB/Swiss-Prot: SPI1_HUMAN, P17947, Spi-B protein- UniProtKB/Swiss-Prot: SPIB_HUMAN, Q01892. Supporting Information Figure S1 Quantitation of Irf4 and Irf8 mRNA expression in EBV positive and EBNA3C expressing cells. Total RNA was isolated from BAC-GFP EBV infected PBMC cells (at different...”
- Acetylation Increases EWS-FLI1 DNA Binding and Transcriptional Activity.
Schlottmann, Frontiers in oncology 2012 - “...relevant lysine positions. Protein sequences of ETS1 (P14921), ETS2 (P15036), ETV6 (P41212), ETV7 (Q9Y603), SPIB (Q01892), SPI1 (P17947), ETV1 (P50549), ETV5 (P41161), ETV4 (P43268), ERG (P11308), FLI1 (Q01543), FEV (Q99581), and ETV2 (O00321) were aligned using UniProt, to reveal conservation of Lysine positions K240, K252, K380,...”
- spib is required for primitive myeloid development in Xenopus.
Costa, Blood 2008 - “...D, G, and I,J represent ventral views. The following database sequences were used: Hs spib Q01892, Mm spib O35906, Xl spiba BC046671, Xl spibb BC130210, Xt spib IMAGE 7023083, Hs spi1 P17947, Mm spi1 P17433, Gg spi1 NP_990354, Xt spi1 BC098077, and Dr spi1 CAD58735 (outgroup...”
- IGSF10 inhibits the metastasis of lung adenocarcinoma via the Spi-B/Integrin-β1 signaling pathway.
Ling, Journal of biochemical and molecular toxicology 2024 (PubMed)- GeneRIF: IGSF10 inhibits the metastasis of lung adenocarcinoma via the Spi-B/Integrin-beta1 signaling pathway.
- Peroxiredoxin2 regulates trophoblast proliferation and migration through SPIB-HDAC2 pathway.
Wu, Experimental cell research 2023 (PubMed)- GeneRIF: Peroxiredoxin2 regulates trophoblast proliferation and migration through SPIB-HDAC2 pathway.
- SPIB Knockdown Inhibits the Immune Escape of Ovarian Cancer Cells by Reducing PD-L1 (CD274) Expression and Inactivating the JAK/STAT Pathway.
Gu, Iranian journal of immunology : IJI 2023 (PubMed)- GeneRIF: SPIB Knockdown Inhibits the Immune Escape of Ovarian Cancer Cells by Reducing PD-L1 (CD274) Expression and Inactivating the JAK/STAT Pathway.
- SPI1-related protein inhibits cervical cancer cell progression and prevents macrophage cell migration.
Jin, The journal of obstetrics and gynaecology research 2022 (PubMed)- GeneRIF: SPI1-related protein inhibits cervical cancer cell progression and prevents macrophage cell migration.
- Integrated transcriptomic and regulatory network analyses uncovers the role of let-7b-5p, SPIB, and HLA-DPB1 in sepsis.
Mohsin, Scientific reports 2022 - GeneRIF: Integrated transcriptomic and regulatory network analyses uncovers the role of let-7b-5p, SPIB, and HLA-DPB1 in sepsis.
- Comprehensive pan-cancer analysis reveals the prognostic value and immunological role of SPIB.
Ding, Aging 2022 - GeneRIF: Comprehensive pan-cancer analysis reveals the prognostic value and immunological role of SPIB.
- SPIB acts as a tumor suppressor by activating the NFkB and JNK signaling pathways through MAP4K1 in colorectal cancer cells.
Zhao, Cellular signalling 2021 (PubMed)- GeneRIF: SPIB acts as a tumor suppressor by activating the NFkB and JNK signaling pathways through MAP4K1 in colorectal cancer cells.
- SPIB promotes anoikis resistance via elevated autolysosomal process in lung cancer cells.
Zhang, The FEBS journal 2020 (PubMed)- GeneRIF: SPIB promotes anoikis resistance via elevated autolysosomal process in lung cancer cells.
- More
XP_021432878 transcription factor Spi-C isoform X1 from Oncorhynchus mykiss
36% identity, 30% coverage
For advice on how to use these tools together, see
Interactive tools for functional annotation of bacterial genomes.
The PaperBLAST database links 798,070 different protein sequences to 1,261,478 scientific articles. Searches against EuropePMC were last performed on May 12 2025.
PaperBLAST builds a database of protein sequences that are linked
to scientific articles. These links come from automated text searches
against the articles in EuropePMC
and from manually-curated information from GeneRIF, UniProtKB/Swiss-Prot,
BRENDA,
CAZy (as made available by dbCAN),
BioLiP,
CharProtDB,
MetaCyc,
EcoCyc,
TCDB,
REBASE,
the Fitness Browser,
and a subset of the European Nucleotide Archive with the /experiment tag.
Given this database and a protein sequence query,
PaperBLAST uses protein-protein BLAST
to find similar sequences with E < 0.001.
To build the database, we query EuropePMC with locus tags, with RefSeq protein
identifiers, and with UniProt
accessions. We obtain the locus tags from RefSeq or from MicrobesOnline. We use
queries of the form "locus_tag AND genus_name" to try to ensure that
the paper is actually discussing that gene. Because EuropePMC indexes
most recent biomedical papers, even if they are not open access, some
of the links may be to papers that you cannot read or that our
computers cannot read. We query each of these identifiers that
appears in the open access part of EuropePMC, as well as every locus
tag that appears in the 500 most-referenced genomes, so that a gene
may appear in the PaperBLAST results even though none of the papers
that mention it are open access. We also incorporate text-mined links
from EuropePMC that link open access articles to UniProt or RefSeq
identifiers. (This yields some additional links because EuropePMC
uses different heuristics for their text mining than we do.)
For every article that mentions a locus tag, a RefSeq protein
identifier, or a UniProt accession, we try to select one or two
snippets of text that refer to the protein. If we cannot get access to
the full text, we try to select a snippet from the abstract, but
unfortunately, unique identifiers such as locus tags are rarely
provided in abstracts.
PaperBLAST also incorporates manually-curated protein functions:
- Proteins from NCBI's RefSeq are included if a
GeneRIF
entry links the gene to an article in
PubMed®.
GeneRIF also provides a short summary of the article's claim about the
protein, which is shown instead of a snippet.
- Proteins from Swiss-Prot (the curated part of UniProt)
are included if the curators
identified experimental evidence for the protein's function (evidence
code ECO:0000269). For these proteins, the fields of the Swiss-Prot entry that
describe the protein's function are shown (with bold headings).
- Proteins from BRENDA,
a curated database of enzymes, are included if they are linked to a paper in PubMed
and their full sequence is known.
- Every protein from the non-redundant subset of
BioLiP,
a database
of ligand-binding sites and catalytic residues in protein structures, is included. Since BioLiP itself
does not include descriptions of the proteins, those are taken from the
Protein Data Bank.
Descriptions from PDB rely on the original submitter of the
structure and cannot be updated by others, so they may be less reliable.
(For SitesBLAST and Sites on a Tree, we use a larger subset of BioLiP so that every
ligand is represented among a group of structures with similar sequences, but for
PaperBLAST, we use the non-redundant set provided by BioLiP.)
- Every protein from EcoCyc, a curated
database of the proteins in Escherichia coli K-12, is included, regardless
of whether they are characterized or not.
- Proteins from the MetaCyc metabolic pathway database
are included if they are linked to a paper in PubMed and their full sequence is known.
- Proteins from the Transport Classification Database (TCDB)
are included if they have known substrate(s), have reference(s),
and are not described as uncharacterized or putative.
(Some of the references are not visible on the PaperBLAST web site.)
- Every protein from CharProtDB,
a database of experimentally characterized protein annotations, is included.
- Proteins from the CAZy database of carbohydrate-active enzymes
are included if they are associated with an Enzyme Classification number.
Even though CAZy does not provide links from individual protein sequences to papers,
these should all be experimentally-characterized proteins.
- Proteins from the REBASE database
of restriction enzymes are included if they have known specificity.
- Every protein with an evidence-based reannotation (based on mutant phenotypes)
in the Fitness Browser is included.
- Sequence-specific transcription factors (including sigma factors and DNA-binding response regulators)
with experimentally-determined DNA binding sites from the
PRODORIC database of gene regulation in prokaryotes.
- Putative transcription factors from RegPrecise
that have manually-curated predictions for their binding sites. These predictions are based on
conserved putative regulatory sites across genomes that contain similar transcription factors,
so PaperBLAST clusters the TFs at 70% identity and retains just one member of each cluster.
- Coding sequence (CDS) features from the
European Nucleotide Archive (ENA)
are included if the /experiment tag is set (implying that there is experimental evidence for the annotation),
the nucleotide entry links to paper(s) in PubMed,
and the nucleotide entry is from the STD data class
(implying that these are targeted annotated sequences, not from shotgun sequencing).
Also, to filter out genes whose transcription or translation was detected, but whose function
was not studied, nucleotide entries or papers with more than 25 such proteins are excluded.
Descriptions from ENA rely on the original submitter of the
sequence and cannot be updated by others, so they may be less reliable.
Except for GeneRIF and ENA,
the curated entries include a short curated
description of the protein's function.
For entries from BioLiP, the protein's function may not be known beyond binding to the ligand.
Many of these entries also link to articles in PubMed.
For more information see the
PaperBLAST paper (mSystems 2017)
or the code.
You can download PaperBLAST's database here.
Changes to PaperBLAST since the paper was written:
- November 2023: incorporated PRODORIC and RegPrecise. Many PRODORIC entries were not linked to a protein sequence (no UniProt identifier), so we added this information.
- February 2023: BioLiP changed their download format. PaperBLAST now includes their non-redundant subset. SitesBLAST and Sites on a Tree use a larger non-redundant subset that ensures that every ligand is represented within each cluster. This should ensure that every binding site is represented.
- June 2022: incorporated some coding sequences from ENA with the /experiment tag.
- March 2022: incorporated BioLiP.
- April 2020: incorporated TCDB.
- April 2019: EuropePMC now returns table entries in their search results. This has expanded PaperBLAST's database, but most of the new entries are of low relevance, and the resulting snippets are often just lists of locus tags with annotations.
- February 2018: the alignment page reports the conservation of the hit's functional sites (if available from from Swiss-Prot or UniProt)
- January 2018: incorporated BRENDA.
- December 2017: incorporated MetaCyc, CharProtDB, CAZy, REBASE, and the reannotations from the Fitness Browser.
- September 2017: EuropePMC no longer returns some table entries in their search results. This has shrunk PaperBLAST's database, but has also reduced the number of low-relevance hits.
Many of these changes are described in Interactive tools for functional annotation of bacterial genomes.
PaperBLAST cannot provide snippets for many of the papers that are
published in non-open-access journals. This limitation applies even if
the paper is marked as "free" on the publisher's web site and is
available in PubmedCentral or EuropePMC. If a journal that you publish
in is marked as "secret," please consider publishing elsewhere.
Many important articles are missing from PaperBLAST, either because
the article's full text is not in EuropePMC (as for many older
articles), or because the paper does not mention a protein identifier such as a locus tag, or because of PaperBLAST's heuristics. If you notice an
article that characterizes a protein's function but is missing from
PaperBLAST, please notify the curators at UniProt
or add an entry to GeneRIF.
Entries in either of these databases will eventually be incorporated
into PaperBLAST. Note that to add an entry to UniProt, you will need
to find the UniProt identifier for the protein. If the protein is not
already in UniProt, you can ask them to create an entry. To add an
entry to GeneRIF, you will need an NCBI Gene identifier, but
unfortunately many prokaryotic proteins in RefSeq do not have
corresponding Gene identifers.
References
PaperBLAST: Text-mining papers for information about homologs.
M. N. Price and A. P. Arkin (2017). mSystems, 10.1128/mSystems.00039-17.
Europe PMC in 2017.
M. Levchenko et al (2017). Nucleic Acids Research, 10.1093/nar/gkx1005.
Gene indexing: characterization and analysis of NLM's GeneRIFs.
J. A. Mitchell et al (2003). AMIA Annu Symp Proc 2003:460-464.
UniProt: the universal protein knowledgebase.
The UniProt Consortium (2016). Nucleic Acids Research, 10.1093/nar/gkw1099.
BRENDA in 2017: new perspectives and new tools in BRENDA.
S. Placzek et al (2017). Nucleic Acids Research, 10.1093/nar/gkw952.
The EcoCyc database: reflecting new knowledge about Escherichia coli K-12.
I. M. Keeseler et al (2016). Nucleic Acids Research, 10.1093/nar/gkw1003.
The MetaCyc database of metabolic pathways and enzymes.
R. Caspi et al (2018). Nucleic Acids Research, 10.1093/nar/gkx935.
CharProtDB: a database of experimentally characterized protein annotations.
R. Madupu et al (2012). Nucleic Acids Research, 10.1093/nar/gkr1133.
The carbohydrate-active enzymes database (CAZy) in 2013.
V. Lombard et al (2014). Nucleic Acids Research, 10.1093/nar/gkt1178.
The Transporter Classification Database (TCDB): recent advances
M. H. Saier, Jr. et al (2016). Nucleic Acids Research, 10.1093/nar/gkv1103.
REBASE - a database for DNA restriction and modification: enzymes, genes and genomes.
R. J. Roberts et al (2015). Nucleic Acids Research, 10.1093/nar/gku1046.
Deep annotation of protein function across diverse bacteria from mutant phenotypes.
M. N. Price et al (2016). bioRxiv, 10.1101/072470.
by Morgan Price,
Arkin group
Lawrence Berkeley National Laboratory