PaperBLAST
PaperBLAST Hits for 62 a.a. (SDEYKIRRER...)
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>62 a.a. (SDEYKIRRER...)
SDEYKIRRERNNIAVRKSRDKAKMRNLETQHKVLELTAENERLQKKVEQLSRELSTLRNL
FK
Running BLASTp...
Found 54 similar proteins in the literature:
XP_004014932 CCAAT/enhancer-binding protein beta from Ovis aries
100% identity, 18% coverage
XP_003467861 CCAAT/enhancer-binding protein beta from Cavia porcellus
100% identity, 18% coverage
NP_001186818 CCAAT/enhancer-binding protein beta from Sus scrofa
100% identity, 18% coverage
XP_015004272 CCAAT/enhancer-binding protein beta from Macaca mulatta
100% identity, 18% coverage
CEBPB_HUMAN / P17676 CCAAT/enhancer-binding protein beta; C/EBP beta; Liver activator protein; LAP; Liver-enriched inhibitory protein; LIP; Nuclear factor NF-IL6; Transcription factor 5; TCF-5 from Homo sapiens (Human) (see 13 papers)
NP_005185 CCAAT/enhancer-binding protein beta isoform a from Homo sapiens
100% identity, 18% coverage
- function: Important transcription factor regulating the expression of genes involved in immune and inflammatory responses (PubMed:12048245, PubMed:1741402, PubMed:18647749, PubMed:9374525). Also plays a significant role in adipogenesis, as well as in the gluconeogenic pathway, liver regeneration, and hematopoiesis. The consensus recognition site is 5'-T[TG]NNGNAA[TG]-3'. Its functional capacity is governed by protein interactions and post-translational protein modifications. During early embryogenesis, plays essential and redundant roles with CEBPA. Has a promitotic effect on many cell types such as hepatocytes and adipocytes but has an antiproliferative effect on T-cells by repressing MYC expression, facilitating differentiation along the T-helper 2 lineage. Binds to regulatory regions of several acute-phase and cytokines genes and plays a role in the regulation of acute-phase reaction and inflammation. Also plays a role in intracellular bacteria killing (By similarity). During adipogenesis, is rapidly expressed and, after activation by phosphorylation, induces CEBPA and PPARG, which turn on the series of adipocyte genes that give rise to the adipocyte phenotype. The delayed transactivation of the CEBPA and PPARG genes by CEBPB appears necessary to allow mitotic clonal expansion and thereby progression of terminal differentiation (PubMed:20829347). Essential for female reproduction because of a critical role in ovarian follicle development (By similarity). Restricts osteoclastogenesis: together with NFE2L1; represses expression of DSPP during odontoblast differentiation (By similarity).
function: [Isoform 2]: Essential for gene expression induction in activated macrophages. Plays a major role in immune responses such as CD4(+) T-cell response, granuloma formation and endotoxin shock. Not essential for intracellular bacteria killing.
function: [Isoform 3]: Acts as a dominant negative through heterodimerization with isoform 2 (PubMed:11741938). Promotes osteoblast differentiation and osteoclastogenesis (By similarity).
subunit: Binds DNA as a homodimer and as a heterodimer (PubMed:11018027, PubMed:11257229, PubMed:11792321). Interacts with ATF4. Binds DNA as a heterodimer with ATF4 (PubMed:11018027). Interacts with MYB; within the complex, MYB and CEBPB bind to different promoter regions (PubMed:11792321). Can form stable heterodimers with CEBPD (PubMed:1741402). Can form stable heterodimers with CEBPA and CEBPE (By similarity). Interacts with SIX1 (PubMed:27923061). Isoform 2 and isoform 3 also form heterodimers. Interacts with TRIM28 and PTGES2. Interacts with PRDM16. Interacts with CCDC85B. Forms a complex with THOC5. Interacts with ZNF638; this interaction increases transcriptional activation. Interacts with CIDEA and CIDEC; these interactions increase transcriptional activation of a subset of CEBPB downstream target genes (By similarity). Interacts with DDIT3/CHOP (PubMed:20829347). Interacts with EP300; recruits EP300 to chromatin. Interacts with RORA; the interaction disrupts interaction with EP300. Interacts (not methylated) with MED23, MED26, SMARCA2, SMARCB1 and SMARCC1 (PubMed:20111005). Interacts with KAT2A and KAT2B (By similarity). Interacts with ATF5; EP300 is required for ATF5 and CEBPB interaction and DNA binding (By similarity). Interacts with NFE2L1; the heterodimer represses expression of DSPP during odontoblast differentiation (By similarity). - [C/EBPβ mediates expressions of downstream inflammatory factors of the tumor necrosis factor-α signaling pathway in renal tubular epithelial cells with NPHP1 knockdown].
Huang, Nan fang yi ke da xue xue bao = Journal of Southern Medical University 2024 - GeneRIF: [C/EBPbeta mediates expressions of downstream inflammatory factors of the tumor necrosis factor-alpha signaling pathway in renal tubular epithelial cells with NPHP1 knockdown].
- MiR-155-5p improves the insulin sensitivity of trophoblasts by targeting CEBPB in gestational diabetes mellitus.
Zhang, Placenta 2024 (PubMed)- GeneRIF: MiR-155-5p improves the insulin sensitivity of trophoblasts by targeting CEBPB in gestational diabetes mellitus.
- rs822336 binding to C/EBPβ and NFIC modulates induction of PD-L1 expression and predicts anti-PD-1/PD-L1 therapy in advanced NSCLC.
Polcaro, Molecular cancer 2024 - GeneRIF: rs822336 binding to C/EBPbeta and NFIC modulates induction of PD-L1 expression and predicts anti-PD-1/PD-L1 therapy in advanced NSCLC.
- Dysregulation of TNF-induced protein 3 and CCAAT/enhancer-binding protein β in alveolar macrophages: Implications for systemic sclerosis-associated interstitial lung disease.
Hua, International journal of rheumatic diseases 2024 (PubMed)- GeneRIF: Dysregulation of TNF-induced protein 3 and CCAAT/enhancer-binding protein beta in alveolar macrophages: Implications for systemic sclerosis-associated interstitial lung disease.
- Genetic disruption of ATAT1 causes RhoA downregulation through abnormal truncation of C/EBPβ.
Choi, BMB reports 2024 - GeneRIF: Genetic disruption of ATAT1 causes RhoA downregulation through abnormal truncation of C/EBPbeta.
- C/EBPβ Regulates TFAM Expression, Mitochondrial Function and Autophagy in Cellular Models of Parkinson's Disease.
Sierra-Magro, International journal of molecular sciences 2023 - GeneRIF: C/EBPbeta Regulates TFAM Expression, Mitochondrial Function and Autophagy in Cellular Models of Parkinson's Disease.
- C/EBP-Family Redundancy Determines Patient Survival and Lymph Node Involvement in PDAC.
Hartl, International journal of molecular sciences 2023 - GeneRIF: C/EBP-Family Redundancy Determines Patient Survival and Lymph Node Involvement in PDAC.
- C/EBPβ expression decreases in cervical cancer and leads to tumorigenesis.
Long, BMC cancer 2023 - GeneRIF: C/EBPbeta expression decreases in cervical cancer and leads to tumorigenesis.
- More
- Structural basis for specific DNA sequence recognition by the transcription factor NFIL3.
Chen, The Journal of biological chemistry 2024 - “...Q16649); TEF (UniProt: Q10587); HLF (UniProt: Q16534); DBP (UniProt: Q10586); C/EBP (UniProt: P49715); C/EBP (UniProt: P17676); C/EBP (UniProt: P49716); C/EBP (UniProt: Q15744); C/EBP (UniProt: P53567); C/EBP (UniProt: P35638). bZIP: basic region-leucine zipper domain. The phylogenetic tree was generated using the amino acid sequences of the bZIP...”
- Blood Proteome Profiling Reveals Biomarkers and Pathway Alterations in Fragile X PM at Risk for Developing FXTAS.
Zafarullah, International journal of molecular sciences 2023 - “...0.002199 0.421168 0.055764 0.3596959 10 P42025 ACTR1B Beta-centractin 0.7463896 0.0034287 0.0000198 0.920365 0.498285 0.2063338 11 P17676 CEBPB CCAAT/enhancer-binding protein beta 0.3772653 0.0006946 0.0443946 0.649723 0.035408 0.7433883 12 Q6P1A2 LPCAT3 Lysophospholipid acyltransferase 5 0.2781298 0.0015861 0.077895 0.783158 0.008247 0.499658 13 O00422 SAP18 Histone deacetylase complex subunit SAP18...”
- “...protein YY1 10 Q96N66 MBOAT7 1.49 13.45 3.48 10 6 0.0006946 Lysophospholipid acyltransferase 7 11 P17676 CEBPB 2.16 13.57 3.67 10 6 0.0006946 CCAAT/enhancer-binding protein beta 12 P50552 VASP 0.45 15.4 3.90 10 6 0.0006946 Vasodilator-stimulated phosphoprotein 13 Q96CN7 ISOC1 1.29 13.18 4.39 10 6 0.0006946...”
- Andrographolide in atherosclerosis: integrating network pharmacology and in vitro pharmacological evaluation
Shi, Bioscience reports 2022 - “...dependent kinase inhibitor 1A CTD 18 P49715 CEBPA CCAAT enhancer binding protein alpha CTD 19 P17676 CEBPB CCAAT enhancer binding protein beta CTD 20 Q6UWW8 CES3 Carboxylesterase 3 CTD 21 Q9NSE2 CISH Cytokine inducible SH2 containing protein CTD 22 Q99439 CNN2 Calponin 2 CTD 23 P08123...”
- Identifying potential drug targets and candidate drugs for COVID-19: biological networks and structural modeling approaches
Selvaraj, F1000Research 2021 - “...81 6405.31 1.046 P22681 5HKX -285.74 -257.97 -244.71 CEBPB N, NP, CP 28 2647.13 -1.869 P17676 3A5T -235.81 -220.39 -227.41 CRKL EN, C, EX 32 1158.21 1.081 P46108 2EYZ -302.98 -273.78 -276.28 ERBB4 * N, NP, M, C, PM 34 3037.11 -2.052 Q15303 3U9U -289.18 -280.6...”
- The Protective Effect of Liquiritin in Hypoxia/Reoxygenation-Induced Disruption on Blood Brain Barrier.
Li, Frontiers in pharmacology 2021 - “...Lanosterol 14-alpha demethylase Q9UKR5 ERG28 Ergosterol biosynthetic protein 28 Q6P0Q8 MAST2 Microtubule-associated serine/threonine-protein kinase 2 P17676 CEBPB CCAAT/enhancer-binding protein beta P78383 SLC35B1 Solute carrier family 35 member B1 Q8TCD5 NT5C 5 (3)-deoxyribonucleotidase, cytosolic type Q99759 MAP3K3 Mitogen-activated protein kinase kinase 3 Q04206 RELA Transcription factor p65...”
- Data on bioactive peptides derived from chicken hydrolysate with potential alcohol dehydrogenase stabilizing activity and in silico analysis of their potential activity and applicability.
Xiao, Data in brief 2020 - “...Amphipa thicity Hydropho bicity pI Molecular Weight (Da) 1 DPDDFPL 0.91 non-allergen UniProtKB accession number P17676 Non-Toxin 0.88 0.6 0 0.17 3.43 817.35 2 NKISVVGVGAVGMACAISILMKDLA 0.86 non-allergen UniProtKB accession number Q10ST8 Non-Toxin 1.47 0.65 0.29 0.13 8.54 2459.33 3 DPQYPPGPPAFP 0.85 non-allergen UniProtKB accession number Q9S8M0...”
- Structural basis for effects of CpA modifications on C/EBPβ binding of DNA
Yang, Nucleic acids research 2019 - “...expression and purification We prepared C-terminal bZIP domain of human C/EBP (residues 269344; UniProtKB/ Swiss-Prot: P17676) ( Supplementary Figure S1 ). The DNA binding domain (pXC1599) and its variant V285A (pXC2027) were expressed as N-terminal 6xHis-SUMO fusion proteins ( 39 ), via a modified pET28b vector...”
- Comparison of protein expression during wild-type, and E1B-55k-deletion, adenovirus infection using quantitative time-course proteomics.
Fu, The Journal of general virology 2017 - “...Q7Z5L9 Interferon regulatory factor 2-binding protein 2 IRF2BP2 0.61 P15428 15-hydroxyprostaglandin dehydrogenase [NAD(+)] HPGD 0.72 P17676 CCAAT/enhancer-binding protein beta CEBPB 0.24 H0Y485 Insulin-like growth factor-binding protein 3 IGFBP3 0.87 P40189 Interleukin-6 receptor subunit beta IL6ST 0.97 A0A087WV90 Dystrophin DMD 1.19 Q12860 Contactin-1 CNTN1 Not detected Q8IY57...”
- More
XP_021139454 CCAAT/enhancer-binding protein beta from Columba livia
98% identity, 19% coverage
- Molecular cloning, characterisation, and expression patterns of pigeon CCAAT/enhancer binding protein-α and -β genes.
Tian, British poultry science 2019 (PubMed)- GeneRIF: The mRNA expression levels of pigeon C/EBP-alpha in descending order, were in spleen, heart, liver, lung, kidney and muscle. The pigeon C/EBP-beta gene had the most abundant expression in lung, followed by the kidney, with minimal expression detected in muscle.
CEBPB_CHICK / Q05826 CCAAT/enhancer-binding protein beta; C/EBP beta; Transcription factor NF-M; CCR protein from Gallus gallus (Chicken) (see 3 papers)
NP_990584 CCAAT/enhancer-binding protein beta from Gallus gallus
98% identity, 19% coverage
- function: Important transcriptional activator regulating the expression of genes involved in immune and inflammatory responses. Binds to regulatory regions of several acute-phase and cytokines genes and probably plays a role in the regulation of acute-phase reaction, inflammation and hemopoiesis. The consensus recognition site is 5'- T[TG]NNGNAA[TG]-3'. Functions in brown adipose tissue (BAT) differentiation. Regulates the transcriptional induction of peroxisome proliferator-activated receptor gamma (PPARG). Binds to the MGF and MIM-1 promoters and activates the transcription of these genes.
function: Important transcription factor regulating the expression of genes involved in immune and inflammatory responses (PubMed:8467792). Also plays a significant role in adipogenesis, as well as in the gluconeogenic pathway, liver regeneration, and hematopoiesis. The consensus recognition site is 5'-T[TG]NNGNAA[TG]-3'. Its functional capacity is governed by protein interactions and post-translational protein modifications.
subunit: Binds DNA as a dimer. Interacts (not methylated) with MED23, MED26, SMARCA2, SMARCB1 and SMARCC1 (PubMed:20111005). - Expression profiles of key transcription factors involved in lipid metabolism in Beijing-You chickens.
Fu, Gene 2014 (PubMed)- GeneRIF: C-EBP beta involved in lipid metabolism in Beijing-You chickens.
- v-Myc inhibits C/EBPbeta activity by preventing C/EBPbeta-induced phosphorylation of the co-activator p300.
Steinmann, Oncogene 2009 (PubMed)- GeneRIF: modulation of the C/EBPbeta-induced phosphorylation of p300 is a new mechanism of transcriptional suppression by v-Myc.
- C/EBPbeta induces chromatin opening at a cell-type-specific enhancer.
Plachetka, Molecular and cellular biology 2008 - GeneRIF: In the absence of Myb, C/EBPbeta triggers the initial steps of chromatin opening at the mim-1 enhancer without inducing transcription of the gene.
- Regulation of C/EBPbeta mRNA expression and C/EBPbeta promoter activity by protein kinases A and C in a myelomonocytic cell line (HD11).
Goethe, Inflammation research : official journal of the European Histamine Research Society ... [et al.] 2007 (PubMed)- GeneRIF: Results indicate that the C/EBPbeta gene is regulated transcriptionally as well as post-transcriptionally in response to forskolin and PMA, and the forskolin responsiveness of the C/EBPbeta promoter seems to depend on cellular cAMP turnover.
- Identification of a Myb-responsive enhancer of the chicken C/EBPbeta gene.
Kintscher, Oncogene 2004 (PubMed)- GeneRIF: Myb activation of the promoter requires the cooperation with C/EBPbeta, activation of the enhancer by Myb is independent of CCAAT box/enhancer binding protein beta
- Baicalin inhibits inflammation caused by coinfection of Mycoplasma gallisepticum and Escherichia coli involving IL-17 signaling pathway
Wu, Poultry science 2020 - “...UniProtKB IDs were as follows: TRAF6, E1C626; CIKS, F1NQU5; NF-B, Q04861; AP-1, P18870; and C/EBP, Q05826. As the 3D structure of these 5 proteins ( Gallus gallus ) has not been elucidated yet, method of comparative modeling was used for their 3D structure. This alignment was...”
- The functional diversity of protein lysine methylation
Lanouette, Molecular systems biology 2014 - “...? viv; MS, AB* Negatively regulates hypoxiaresponsive genes Lee ( 2010 ) Mol. Cell C/EBP Q05826, P28033, P21272 39 ? Mm, Rn G9a ? viv, vit; RD Inhibition of transactivation potential Pless ( 2008 ) JBC ARID5B Q14865 336 2Me Hs ? PHF2 viv; MS, AB...”
- A salmonid EST genomic study: genes, duplications, phylogeny and microarrays.
Koop, BMC genomics 2008 - “...- - - Q8VHZ7 1.0E-125 U3 small nucleolar ribonucleoprotein 19 10 314 - - yes Q05826 1.0E-35 CCAAT/enhancer-binding protein beta 20 18 313 - - yes P97371 1.0E-68 Proteasome activator complex subunit 1 21 10 505 - C/T yes Q96GG9 1.0E-135 DCN1-like protein 1 22 10...”
NP_001274667 CCAAT/enhancer-binding protein beta isoform b from Mus musculus
98% identity, 23% coverage
CEBPB_MOUSE / P28033 CCAAT/enhancer-binding protein beta; C/EBP beta; AGP/EBP; Interleukin-6-dependent-binding protein; IL-6DBP; Liver-enriched transcriptional activator; LAP from Mus musculus (Mouse) (see 28 papers)
98% identity, 21% coverage
- function: Important transcription factor regulating the expression of genes involved in immune and inflammatory responses (PubMed:16585579, PubMed:17911624, PubMed:18486321, PubMed:20111005). Also plays a significant role in adipogenesis, as well as in the gluconeogenic pathway, liver regeneration, and hematopoiesis (PubMed:10635333, PubMed:17301242, PubMed:17601773, PubMed:19478079, PubMed:24061474, PubMed:24216764, PubMed:9727068). The consensus recognition site is 5'- T[TG]NNGNAA[TG]-3'. Its functional capacity is governed by protein interactions and post-translational protein modifications. During early embryogenesis, plays essential and redundant roles with CEBPA (PubMed:15509779). Has a promitotic effect on many cell types such as hepatocytes and adipocytes but has an antiproliferative effect on T- cells by repressing MYC expression, facilitating differentiation along the T-helper 2 lineage (PubMed:10635333, PubMed:16585579, PubMed:9727068). Binds to regulatory regions of several acute-phase and cytokines genes and plays a role in the regulation of acute-phase reaction and inflammation. Also plays a role in intracellular bacteria killing (PubMed:17911624). During adipogenesis, is rapidly expressed and, after activation by phosphorylation, induces CEBPA and PPARG, which turn on the series of adipocyte genes that give rise to the adipocyte phenotype. The delayed transactivation of the CEBPA and PPARG genes by CEBPB appears necessary to allow mitotic clonal expansion and thereby progression of terminal differentiation (PubMed:15985551, PubMed:17301242, PubMed:17601773, PubMed:20194620). Essential for female reproduction because of a critical role in ovarian follicle development (PubMed:9303532). Restricts osteoclastogenesis (PubMed:19440205). Together with NFE2L1; represses expression of DSPP during odontoblast differentiation (By similarity).
function: [Isoform 2]: Essential for gene expression induction in activated macrophages. Plays a major role in immune responses such as CD4(+) T-cell response, granuloma formation and endotoxin shock. Not essential for intracellular bacteria killing.
function: [Isoform 3]: Acts as a dominant negative through heterodimerization with isoform 2 (By similarity). Promotes osteoblast differentiation and osteoclastogenesis (PubMed:19440205).
subunit: Binds DNA as a homodimer and as a heterodimer. Interacts with ATF4. Binds DNA as a heterodimer with ATF4 (PubMed:11018027). Interacts with MYB; within the complex, MYB and CEBPB bind to different promoter regions (PubMed:11792321). Can form stable heterodimers with CEBPA, CEBPD and CEBPE (By similarity). Interacts with SIX1 (PubMed:27923061). Isoform 2 and isoform 3 also form heterodimers (By similarity). Interacts with TRIM28 and PTGES2 (PubMed:15879117, PubMed:9742105). Interacts with PRDM16 (PubMed:19641492). Interacts with CCDC85B (PubMed:15644333). Forms a complex with THOC5 (PubMed:19015024). Interacts with ZNF638; this interaction increases transcriptional activation (PubMed:21602272). Interacts with CIDEA and CIDEC (PubMed:22245780). Interaction with CIDEA increases transcriptional activation of a subset of CEBPB downstream target genes, including ID2, IGF1, PRLR, SOCS1, SOCS3, XDH. Interaction with CIDEC increases transcriptional activation of SOCS1, SOCS3, TGFB1, TGFBR1, ID2 and XDH. Interacts with DDIT3/CHOP. Interacts with EP300; recruits EP300 to chromatin. Interacts with RORA; the interaction disrupts interaction with EP300 (PubMed:19324970). Interacts (not methylated) with MED23, MED26, SMARCA2, SMARCB1 and SMARCC1 (PubMed:20111005). Interacts with KAT2A and KAT2B (PubMed:17301242). Interacts with ATF5; EP300 is required for ATF5 and CEBPB interaction and DNA binding (PubMed:24216764). Interacts with NFE2L1; the heterodimer represses expression of DSPP during odontoblast differentiation (By similarity).
disruption phenotype: Embryos display defects in brown fat tissue development (PubMed:19641492). Females are sterile, ovaries lack corpora lutea (PubMed:9303532). Upon bacterial infection, animals show impaired bactericidal activity and die within 3 days (PubMed:17911624). Posthepatectomy, animals show a reduced regenerative response with DNA synthesis decreased to 25% of normal in hepatocytes and a prolonged period of hypoglycemia (PubMed:9727068). Animals show osteopenia with decreased bone formation and enhanced ostecolastogenesis. Long bones have a 1.6 fold diminished bone volume with a reduction of the number and thickness of bone trabeculae (PubMed:19440205). Mutants of isoform 2 show impaired CSF3/G-CSF production by macrophages, IFNG production by CD4(+) T-cells and granuloma formation in liver. Upon bacterial infection, mutants of isoform 2 die within 6 days. Resistant to LPS- induced endotoxin shock (PubMed:17911624). Double knockout CEBPA and CEBPB results in embryonic developmental arrest and death at around 10 dpc to 11 dpc, associated with a gross placenta failure (PubMed:15509779). - Norbergenin prevents LPS-induced inflammatory responses in macrophages through inhibiting NFκB, MAPK and STAT3 activation and blocking metabolic reprogramming.
Li, Frontiers in immunology 2023 - “...Cyclin-dependent kinase inhibitor 1 -0.908 Down Icam1 P13597 Intercellular adhesion molecule 1 -1.082 Down Cebpb P28033 CCAAT/enhancer-binding protein beta -1.082 Down Cxcl10 P17515 C-X-C motif chemokine 10 -5.978 Down Ccl2 P10148 C-C motif chemokine 2 -4.226 Down Sqstm1 Q64337 Sequestosome-1 -1.309 Down Metabolic pathway Cmpk2 Q3U5Q7...”
- Intra- and Inter-individual Differences in the Human Intestinal Microbial Conversion of (-)-Epicatechin and Bioactivity of Its Major Colonic Metabolite 5-(3',4'-Dihydroxy-Phenyl)-γ-Valerolactone in Regulating Nrf2-Mediated Gene Expression.
Liu, Frontiers in nutrition 2022 - “...Phgdh 1.05 (0.608) 1.20 (0.089) P39689 Cyclin-dependent kinase inhibitor 1 Cdkn1a 2.32 (0.513) 6.16 (0.093) P28033 CCAAT/enhancer-binding protein beta Cebpb 1.20 (0.427) 1.04 (0.868) O54790 Transcription factor MafG Mafg 1.23 (0.249) 1.06 (0.718) (B) Caco-2 cell samples Q53FA7 Quinone oxidoreductase PIG3 TP53I3 1.74 (0.577) 3.53 (0.130)...”
- Proteomics Landscape of Host-Pathogen Interaction in Acinetobacter baumannii Infected Mouse Lung
Li, Frontiers in genetics 2021 - “...Quiescin Q6 sulfhydryl oxidase 1 1.29 1.42 Q3U2S8 Hvcn1 Hydrogen voltage-gated channel 1 1.60 1.35 P28033 Cebpb CCAAT/enhancer binding protein (C/EBP), beta 1.26 1.32 Validation The validation using Elisa kits found that key proteins Mmp9 and S100a8/a9 were significantly increased in mouse lung tissue during A....”
- Identification of chronic brain protein changes and protein targets of serum auto-antibodies after blast-mediated traumatic brain injury
Harper, Heliyon 2020 - “...IPI00555113 (+1) 22 kDa 1 P35980 Rpl18 CCAAT/enhancer-binding protein beta IPI00116613 (+3) 31 kDa 1 P28033 Cebpb 60S ribosomal protein L8 IPI00137787 28 kDa 1 P62918 Rpl8 60S ribosomal protein L35 IPI00263879 (+1) 15 kDa 1 Q6ZWV7 Rpl35 Histone H1.3 IPI00331597 22 kDa 1 P43277 Hist1h1d...”
- Activating transcription factor 4 (ATF4) promotes skeletal muscle atrophy by forming a heterodimer with the transcriptional regulator C/EBPβ
Ebert, The Journal of biological chemistry 2020 - “...S2 ). B, tandem mass spectrum (MS/MS) from a representative C/EBP peptide VLELTAENER (SwissProt accession P28033) spanning residues 254263 with the precursor ion at m/z 587.31 2 + identified in the ATF4 bZIP affinity-enrichment sample. C, left , quantification of C/EBP peptide VLELTAENER using DIA MS2-based...”
- iTRAQ-Based Quantitative Proteomic Analysis of Intestines in Murine Polymicrobial Sepsis with Hydrogen Gas Treatment.
Jiang, Drug design, development and therapy 2020 - “...Lithostathine-2 Q08731 Reg2 2.0655 1.2855 Sodium/nucleoside cotransporter 2 O88627 Slc28a2 2.009 1.2005 CCAAT/enhancer-binding protein beta P28033 Cebpb 1.8885 1.216 Protein DPCD Q8BPA8 Dpcd 1.8235 1.0625 Alpha-2-antiplasmin Q61247 Serpinf2 1.8155 0.9275 Ribosome biogenesis protein BOP1 P97452 Bop1 1.7595 1.204 Insulin receptor substrate 2 P81122 Irs2 1.7455 1.0835...”
- β-actin contributes to open chromatin for activation of the adipogenic pioneer factor CEBPA during transcriptional reprograming.
Al-Sayegh, Molecular biology of the cell 2020 - “...range. Gene body position (exon: box, intron: line), CEBPB consensus binding motif 5-T[TG]NNGNAA[TG]-3 (UniProtKB - P28033), and positions of the primers for qPCR analysis described in panel B are shown below the tracks. ChIP-Seq profile data for each assay are presented as individual points consisting of...”
- Cutting Edge: Synchronization of IRF1, JunB, and C/EBPβ Activities during TLR3-TLR7 Cross-Talk Orchestrates Timely Cytokine Synergy in the Proinflammatory Response.
Liu, Journal of immunology (Baltimore, Md. : 1950) 2015 - More
CEBPB_RAT / P21272 CCAAT/enhancer-binding protein beta; C/EBP beta; C/EBP-related protein 2; Interleukin-6-dependent-binding protein; IL-6DBP; Liver-enriched inhibitory protein; LIP; Liver-enriched transcriptional activator; LAP; Silencer factor B; SF-B from Rattus norvegicus (Rat) (see 6 papers)
NP_077039 CCAAT/enhancer-binding protein beta isoform LAP1 from Rattus norvegicus
98% identity, 21% coverage
- function: Important transcription factor regulating the expression of genes involved in immune and inflammatory responses (PubMed:8336793). Also plays a significant role in adipogenesis, as well as in the gluconeogenic pathway, liver regeneration, and hematopoiesis (PubMed:10635333). The consensus recognition site is 5'- T[TG]NNGNAA[TG]-3'. Its functional capacity is governed by protein interactions and post-translational protein modifications. During early embryogenesis, plays essential and redundant roles with CEBPA (By similarity). Has a promitotic effect on many cell types such as hepatocytes and adipocytes but has an antiproliferative effect on T- cells by repressing MYC expression, facilitating differentiation along the T-helper 2 lineage (PubMed:10635333). Binds to regulatory regions of several acute-phase and cytokines genes and plays a role in the regulation of acute-phase reaction and inflammation. Also plays a role in intracellular bacteria killing (By similarity). During adipogenesis, is rapidly expressed and, after activation by phosphorylation, induces CEBPA and PPARG, which turn on the series of adipocyte genes that give rise to the adipocyte phenotype. The delayed transactivation of the CEBPA and PPARG genes by CEBPB appears necessary to allow mitotic clonal expansion and thereby progression of terminal differentiation (By similarity). Essential for female reproduction because of a critical role in ovarian follicle development (By similarity). Restricts osteoclastogenesis: together with NFE2L1; represses expression of DSPP during odontoblast differentiation (PubMed:15308669).
function: [Isoform 2]: Essential for gene expression induction in activated macrophages. Plays a major role in immune responses such as CD4(+) T-cell response, granuloma formation and endotoxin shock. Not essential for intracellular bacteria killing.
function: [Isoform 3]: Acts as a dominant negative through heterodimerization with isoform 2 (PubMed:1934061). Promotes osteoblast differentiation and osteoclastogenesis (By similarity).
subunit: Binds DNA as a homodimer and as a heterodimer (PubMed:1934061). Interacts with MYB; within the complex, MYB and CEBPB bind to different promoter regions. Interacts with ATF4. Binds DNA as a heterodimer with ATF4 (By similarity). Can form stable heterodimers with CEBPA, CEBPD, CEBPE and CEBPG (PubMed:1377818, PubMed:1884998). Interacts with SIX1 (By similarity). Isoform 2 and isoform 3 also form heterodimers (PubMed:1934061). Interacts with TRIM28 and PTGES2. Interacts with PRDM16. Interacts with CCDC85B. Forms a complex with THOC5. Interacts with ZNF638; this interaction increases transcriptional activation. Interacts with CIDEA and CIDEC; these interactions increase transcriptional activation of a subset of CEBPB downstream target genes. Interacts with DDIT3/CHOP. Interacts with EP300; recruits EP300 to chromatin. Interacts with RORA; the interaction disrupts interaction with EP300. Interacts (not methylated) with MED23, MED26, SMARCA2, SMARCB1 and SMARCC1 (By similarity). Interacts with KAT2A and KAT2B (By similarity). Interacts with ATF5; EP300 is required for ATF5 and CEBPB interaction and DNA binding (By similarity). Interacts with NFE2L1; the heterodimer represses expression of DSPP during odontoblast differentiation (PubMed:15308669). - A Single-Cell Atlas of the Substantia Nigra Reveals Therapeutic Effects of Icaritin in a Rat Model of Parkinson's Disease.
Wu, Antioxidants (Basel, Switzerland) 2024 - “...cell CLL/lymphoma 11A (zinc finger protein) Rat D3ZSY3 8.56 2 Icaritin CCAAT/enhancer-binding protein beta Rat P21272 6.59 3 Icaritin Mineralocorticoid receptor Rat P22199 10.21 4 Icaritin Mothers against decapentaplegic homolog 3 Rat P84025 9.51 5 Icaritin Transcription factor 4 Rat Q62655 6.15...”
- Space Radiation-Induced Alterations in the Hippocampal Ubiquitin-Proteome System
Tidmore, International journal of molecular sciences 2021 - “...D4AE41 * P18163 P61227 Q505J8 Q7TQ94 F1LNJ2 * P20171 * P62024 Q569C2 Q80W89 F1M386 * P21272 * P62250 Q5HZA6 Q8VHW5 O35179 P29101 P62914 Q5U216 Q9JHL4 O35314 P31647 P63045 Q5XIE8 Q9JJ31 * O35346 * P37285 P69682 Q5XIF3 Q9JKE3 P02650 P40307 P70619 Q5XIG8 Q9JMJ4 P04631 P47863 P84092 Q5XIT1...”
- “...Q80W83 Q9R085 Q9Z269 F1LQ48 P48679 P62243 Q4KLM4 Q68FS2 B0BN85 D4AE41 F1LNJ2 F1M386 O35346 P07153 P20171 P21272 Q62829 Q9JJ31 D3ZBM7 O35821 P10686 P41123 P62268 P62890 Q6RUV5 B0BN85 D4AE41 F1LNJ2 F1LQ48 F1M386 O35346 P07153 P20171 P21272 P48679 P62243 Q4KLM4 Q62829 Q68FS2 Q9JJ31 D3ZBM7 F1LQ48 O35821 P10686 P41123 P48679...”
- Loss of LBP triggers lipid metabolic disorder through H3K27 acetylation-mediated C/EBPβ- SCD activation in non-alcoholic fatty liver disease.
Zhu, Zoological research 2024 - GeneRIF: Loss of LBP triggers lipid metabolic disorder through H3K27 acetylation-mediated C/EBPbeta- SCD activation in non-alcoholic fatty liver disease.
- MOTS-c and aerobic exercise induce cardiac physiological adaptation via NRG1/ErbB4/CEBPβ modification in rats.
Yuan, Life sciences 2023 (PubMed)- GeneRIF: MOTS-c and aerobic exercise induce cardiac physiological adaptation via NRG1/ErbB4/CEBPbeta modification in rats.
- Soluble epoxide hydrolase and TRPC3 channels jointly contribute to homocysteine-induced cardiac hypertrophy: Interrelation and regulation by C/EBPβ.
Zhou, Biochimica et biophysica acta. Molecular basis of disease 2023 (PubMed)- GeneRIF: Soluble epoxide hydrolase and TRPC3 channels jointly contribute to homocysteine-induced cardiac hypertrophy: Interrelation and regulation by C/EBPbeta.
- CEBPB/POU2F2 modulates endothelin 1 expression in prehypertensive SHR vascular smooth muscle cells.
Yang, Journal of molecular endocrinology 2023 - GeneRIF: CEBPB/POU2F2 modulates endothelin 1 expression in prehypertensive SHR vascular smooth muscle cells.
- P53 regulates CCAAT/Enhancer binding protein β gene expression.
Hu, Gene 2023 (PubMed)- GeneRIF: P53 regulates CCAAT/Enhancer binding protein beta gene expression.
- CEBPβ regulation of endogenous IGF-1 in adult sensory neurons can be mobilized to overcome diabetes-induced deficits in bioenergetics and axonal outgrowth.
Aghanoori, Cellular and molecular life sciences : CMLS 2022 - GeneRIF: CEBPbeta regulation of endogenous IGF-1 in adult sensory neurons can be mobilized to overcome diabetes-induced deficits in bioenergetics and axonal outgrowth.
- Metabolic impairment in response to early induction of C/EBPβ leads to compromised cardiac function during pathological hypertrophy.
Banerjee, Journal of molecular and cellular cardiology 2020 (PubMed)- GeneRIF: Metabolic impairment in response to early induction of C/EBPbeta leads to compromised cardiac function during pathological hypertrophy.
- CCAAT/Enhancer-Binding Protein β Mediates Oxygen-Induced Retinal Neovascularization via Retinal Vascular Damage and Vascular Endothelial Growth Factor.
Li, Journal of diabetes research 2020 - GeneRIF: CCAAT/Enhancer-Binding Protein beta Mediates Oxygen-Induced Retinal Neovascularization via Retinal Vascular Damage and Vascular Endothelial Growth Factor.
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Q9BSC0 CEBPB protein (Fragment) from Homo sapiens
100% identity, 45% coverage
1h88B / P17676 Crystal structure of ternary protein-DNA complex1 (see paper)
100% identity, 87% coverage
O02755 CCAAT/enhancer-binding protein beta from Bos taurus
NP_789745 CCAAT/enhancer-binding protein beta from Bos taurus
97% identity, 18% coverage
- Comprehensive EST analysis of the symbiotic sea anemone, Anemonia viridis
Sabourault, BMC genomics 2009 - “...top hit (Uniprot ID) Accession Name Organism E-value CL1Contig11 828 478 CCAAT/enhancer-binding protein beta A7S4U3_NEMVE O02755 CEBPB_BOVIN Bos taurus 5E-17 CL1Contig8 482 1892 Elongation factor 1-alpha A7SSW8_NEMVE P19039 EF1A_APIME Apis mellifera 0 CL2Contig7 340 1411 Actin, cytoplasmic A7SCN8_NEMVE Q964E3 ACTC_BIOAL Biomphalaria alexandrina 0 CL3Contig4 334 764...”
- Overexpression of C/EBPβ Affects The Cell Cycle Regulators and Spermatogenesis Related Genes Expression And Function of Bovine Sertoli Cells.
Tang, Reproduction in domestic animals = Zuchthygiene 2016 (PubMed)- GeneRIF: These results indicate that the C/EBPbeta gene plays an important regulatory role in regulation of the cell cycle regulators and spermatogenesis-related genes expression and function of bovine SCs.
- Stearoyl-CoA desaturase 1 expression is downregulated in liver and udder during E. coli mastitis through enhanced expression of repressive C/EBP factors and reduced expression of the inducer SREBP1A.
Xu, BMC molecular biology 2016 - GeneRIF: SREBP1a activated while C/EBP factors downregulated the activity of the SCD1 promoter.
- Abomasal infusion of arginine stimulates SCD and C/EBPß gene expression, and decreases CPT1ß gene expression in bovine adipose tissue independent of conjugated linoleic acid.
Choi, Amino acids 2014 (PubMed)- GeneRIF: Suppression of CPT1B and induction of SCD and CEBPB by supplemental arginine promotes increased adiposity in Angus steers.
- Co-culture of bovine muscle satellite cells with preadipocytes increases PPARγ and C/EBPβ gene expression in differentiated myoblasts and increases GPR43 gene expression in adipocytes.
Choi, The Journal of nutritional biochemistry 2013 (PubMed)- GeneRIF: Co-culture of adipocytes and myoblasts elicited an increase in C/EBPbeta and PPAR-gamma gene expression in differentiated myoblasts and an increase in GPR43 gene expression in adipocytes.
- Interaction of C/EBP-beta and NF-Y factors constrains activity levels of the nutritionally controlled promoter IA expressing the acetyl-CoA carboxylase-alpha gene in cattle.
Shi, BMC molecular biology 2012 - GeneRIF: Interaction of C/EBP-beta and NF-Y factors constrains activity levels of the nutritionally controlled promoter IA expressing the acetyl-CoA carboxylase-alpha gene in cattle.
- Lingual antimicrobial peptide and IL-8 expression are oppositely regulated by the antagonistic effects of NF-κB p65 and C/EBPβ in mammary epithelial cells.
Liu, Molecular immunology 2011 (PubMed)- GeneRIF: The role of NF-kappaB and C/EBP factors in regulating basal and pathogen-induced expression of both genes from cattle, is investigated.
- Dual effect of a single nucleotide polymorphism in the first intron of the porcine secreted phosphoprotein 1 gene: allele-specific binding of C/EBP beta and activation of aberrant splicing.
Muráni, BMC molecular biology 2009 - GeneRIF: The 3' terminal end of the first intron of porcine SPP1 harbors a C/EBPbeta binding site and this binding site is negatively affected by the mutant G allele.
NP_571959 CCAAT/enhancer-binding protein beta from Danio rerio
87% identity, 22% coverage
Q99557 NF-IL6 (Fragment) from Homo sapiens
100% identity, 62% coverage
NP_001117919 CCAAT enhancer binding protein beta from Oncorhynchus mykiss
85% identity, 21% coverage
Q6P3S4 CEBPA protein from Homo sapiens
76% identity, 44% coverage
XP_003127063 CCAAT/enhancer-binding protein alpha from Sus scrofa
76% identity, 18% coverage
NP_001026630 CCAAT/enhancer-binding protein alpha from Gallus gallus
77% identity, 19% coverage
- CpG site DNA methylation of the CCAAT/enhancer-binding protein, alpha promoter in chicken lines divergently selected for fatness.
Gao, Animal genetics 2015 (PubMed)- GeneRIF: CEBPA promoter is methylated in adipose tissue and may regulate chicken early adipose development
- Expression profiles of key transcription factors involved in lipid metabolism in Beijing-You chickens.
Fu, Gene 2014 (PubMed)- GeneRIF: CEBPA involved in lipid metabolism in Beijing-You chickens.
- Transcriptional regulation of chicken cytochrome P450 2D49 basal expression by CCAAT/enhancer-binding protein α and hepatocyte nuclear factor 4α.
Yang, The FEBS journal 2014 (PubMed)- GeneRIF: The results of overexpressing C/EBPalpha and HNF4alpha in cultured cells confirmed that both C/EBPalpha and HNF4alpha contribute significantly to sustaining a high level of CYP2D49 transcription.
- Folate supplementation modifies CCAAT/enhancer-binding protein α methylation to mediate differentiation of preadipocytes in chickens.
Yu, Poultry science 2014 (PubMed)- GeneRIF: Folate caused a dose-dependent decrease in transcript abundance of peroxisome proliferator-activated receptor gamma (PPARgamma), CCAAT/enhancer-binding protein alpha (C/EBPalpha) gene expression, and the downstream enzyme fatty acid synthase.
- Transdifferentiation of fibroblasts into adipocyte-like cells by chicken adipogenic transcription factors.
Liu, Comparative biochemistry and physiology. Part A, Molecular & integrative physiology 2010 (PubMed)- GeneRIF: The result showed C-EBP alpha was sufficient to trigger the adipogenic program in chicken embryo fibroblasts, as demonstrated by accumulation of cytoplasmic lipid droplets and expression of the adipocyte marker gene.
NP_001165967 CCAAT/enhancer binding protein alpha from Oncorhynchus mykiss
73% identity, 19% coverage
XP_064884492 CCAAT/enhancer-binding protein alpha from Columba livia
76% identity, 19% coverage
- Molecular cloning, characterisation, and expression patterns of pigeon CCAAT/enhancer binding protein-α and -β genes.
Tian, British poultry science 2019 (PubMed)- GeneRIF: The mRNA expression levels of pigeon C/EBP-alpha in descending order, were in spleen, heart, liver, lung, kidney and muscle. The pigeon C/EBP-beta gene had the most abundant expression in lung, followed by the kidney, with minimal expression detected in muscle.
NP_001080275 CCAAT enhancer binding protein alpha L homeolog from Xenopus laevis
73% identity, 20% coverage
CEBPA_RAT / P05554 CCAAT/enhancer-binding protein alpha; C/EBP alpha from Rattus norvegicus (Rat) (see 8 papers)
76% identity, 17% coverage
- function: Transcription factor that coordinates proliferation arrest and the differentiation of myeloid progenitors, adipocytes, hepatocytes, and cells of the lung and the placenta (PubMed:11672531, PubMed:16735515, PubMed:20176812, PubMed:8367486). Binds directly to the consensus DNA sequence 5'-T[TG]NNGNAA[TG]-3' acting as an activator on distinct target genes. During early embryogenesis, plays essential and redundant functions with CEBPB (By similarity). Essential for the transition from common myeloid progenitors (CMP) to granulocyte/monocyte progenitors (GMP) (PubMed:11672531). Critical for the proper development of the liver and the lung (By similarity). Necessary for terminal adipocyte differentiation, is required for postnatal maintenance of systemic energy homeostasis and lipid storage (PubMed:11672531). To regulate these different processes at the proper moment and tissue, interplays with other transcription factors and modulators. Down-regulates the expression of genes that maintain cells in an undifferentiated and proliferative state through E2F1 repression, which is critical for its ability to induce adipocyte and granulocyte terminal differentiation. Reciprocally E2F1 blocks adipocyte differentiation by binding to specific promoters and repressing CEBPA binding to its target gene promoters (PubMed:11672531). Proliferation arrest also depends on a functional binding to SWI/SNF complex (By similarity). In liver, regulates gluconeogenesis and lipogenesis through different mechanisms. To regulate gluconeogenesis, functionally cooperates with FOXO1 binding to IRE-controlled promoters and regulating the expression of target genes such as PCK1 or G6PC1. To modulate lipogenesis, interacts and transcriptionally synergizes with SREBF1 in promoter activation of specific lipogenic target genes such as ACAS2. In adipose tissue, seems to act as FOXO1 coactivator accessing to ADIPOQ promoter through FOXO1 binding sites (By similarity).
function: [Isoform 3]: Can act as dominant-negative. Binds DNA and have transctivation activity, even if much less efficiently than isoform 2. Does not inhibit cell proliferation.
function: [Isoform 4]: Directly and specifically enhances ribosomal DNA transcription interacting with RNA polymerase I-specific cofactors and inducing histone acetylation.
subunit: Binds DNA as a homodimer and as a heterodimer (PubMed:12578822, PubMed:1884998, PubMed:8367486). Can form stable heterodimers with CEBPB, CEBPD, CEBPE and CEBPG (PubMed:1377818, PubMed:1884998). Can form stable homodimers (also isoform 2 and isoform 3 dimers) and heterodimers with CEBPB (with isoform 2 and isoform 3) and CEBPG (PubMed:1377818, PubMed:8367486). Interacts with PRDM16 (By similarity). Interacts with UBN1 (By similarity). Interacts with ZNF638; this interaction increases transcriptional activation (By similarity). Interacts with the complex TFDP2:E2F1; the interaction prevents CEBPA binding to target gene promoters and represses its transcriptional activity (By similarity). Interacts with RB1 (By similarity). Interacts (when phosphorylated at Ser-193) with CDK2, CDK4, E2F4 and SMARCA2 (By similarity). Interacts with SREBPF1 (By similarity). Interacts with FOXO1 (via the Fork-head domain); the interaction increases when FOXO1 is deacetylated (By similarity). Interacts with SIX1 (By similarity). Interacts (via recognition sequence) with TRIB1 (By similarity).
subunit: [Isoform 1]: Interacts with TAF1A and UBTF.
subunit: [Isoform 4]: Interacts with NPM1.
CEBPA_HUMAN / P49715 CCAAT/enhancer-binding protein alpha; C/EBP alpha from Homo sapiens (Human) (see 13 papers)
NP_004355 CCAAT/enhancer-binding protein alpha isoform a from Homo sapiens
76% identity, 17% coverage
- function: Transcription factor that coordinates proliferation arrest and the differentiation of myeloid progenitors, adipocytes, hepatocytes, and cells of the lung and the placenta. Binds directly to the consensus DNA sequence 5'-T[TG]NNGNAA[TG]-3' acting as an activator on distinct target genes (PubMed:11242107). During early embryogenesis, plays essential and redundant functions with CEBPB. Essential for the transition from common myeloid progenitors (CMP) to granulocyte/monocyte progenitors (GMP). Critical for the proper development of the liver and the lung (By similarity). Necessary for terminal adipocyte differentiation, is required for postnatal maintenance of systemic energy homeostasis and lipid storage (By similarity). To regulate these different processes at the proper moment and tissue, interplays with other transcription factors and modulators. Down-regulates the expression of genes that maintain cells in an undifferentiated and proliferative state through E2F1 repression, which is critical for its ability to induce adipocyte and granulocyte terminal differentiation. Reciprocally E2F1 blocks adipocyte differentiation by binding to specific promoters and repressing CEBPA binding to its target gene promoters. Proliferation arrest also depends on a functional binding to SWI/SNF complex (PubMed:14660596). In liver, regulates gluconeogenesis and lipogenesis through different mechanisms. To regulate gluconeogenesis, functionally cooperates with FOXO1 binding to IRE-controlled promoters and regulating the expression of target genes such as PCK1 or G6PC1. To modulate lipogenesis, interacts and transcriptionally synergizes with SREBF1 in promoter activation of specific lipogenic target genes such as ACAS2. In adipose tissue, seems to act as FOXO1 coactivator accessing to ADIPOQ promoter through FOXO1 binding sites (By similarity).
function: [Isoform 3]: Can act as dominant-negative. Binds DNA and have transctivation activity, even if much less efficiently than isoform 2. Does not inhibit cell proliferation (PubMed:14660596).
function: [Isoform 4]: Directly and specifically enhances ribosomal DNA transcription interacting with RNA polymerase I-specific cofactors and inducing histone acetylation.
subunit: Binds DNA as a homodimer and as a heterodimer. Can form stable heterodimers with CEBPB, CEBPD, CEBPE and CEBPG (By similarity). Interacts with PRDM16 (By similarity). Interacts with UBN1 (PubMed:10725330). Interacts with ZNF638; this interaction increases transcriptional activation (By similarity). Interacts with the complex TFDP2:E2F1; the interaction prevents CEBPA binding to target gene promoters and represses its transcriptional activity (PubMed:20176812). Interacts with RB1 (PubMed:15107404). Interacts (when phosphorylated at Ser-190) with CDK2, CDK4, E2F4 and SMARCA2 (PubMed:15107404). Interacts with SREBPF1 (By similarity). Interacts with FOXO1 (via the Fork-head domain); the interaction increases when FOXO1 is deacetylated (By similarity). Interacts with SIX1 (PubMed:27923061). Interacts (via recognition sequence) with TRIB1 (PubMed:20410507, PubMed:26455797). Interacts (via bZIP domain) with OVOL2 (via zinc-finger domains); the interaction inhibits the transcription factor activity of CEBPA and is required to repress adipogenesis (By similarity).
subunit: [Isoform 1]: Interacts with TAF1A and UBTF.
subunit: [Isoform 4]: Interacts with TAF1A and UBTF (PubMed:20075868). Interacts with NPM1 (PubMed:20075868).
subunit: (Microbial infection) Interacts with HBV protein X.
subunit: (Microbial infection) Interacts with Epstein-Barr virus lytic switch protein BZLF1; this interaction induces G1 cell cycle arrest. - In-silico discovery of common molecular signatures for which SARS-CoV-2 infections and lung diseases stimulate each other, and drug repurposing
Alamin, PloS one 2024 - “...proteins (CEBPA, CXCL10, IRF7, IRF9, MSX1, MX2) were obtained from AlphaFold source using Uniprot IDs P49715, P02778, Q92985, Q00978, P28360, P20592. Then molecular docking analyses were performed between m = 17 drug target proteins and n = 184 drug agents to obtain the binding affinity score...”
- Structural basis for specific DNA sequence recognition by the transcription factor NFIL3.
Chen, The Journal of biological chemistry 2024 - “...proteins. NFIL3 (UniProt: Q16649); TEF (UniProt: Q10587); HLF (UniProt: Q16534); DBP (UniProt: Q10586); C/EBP (UniProt: P49715); C/EBP (UniProt: P17676); C/EBP (UniProt: P49716); C/EBP (UniProt: Q15744); C/EBP (UniProt: P53567); C/EBP (UniProt: P35638). bZIP: basic region-leucine zipper domain. The phylogenetic tree was generated using the amino acid sequences...”
- Analysis of the Genetic Relationship between Atherosclerosis and Non-Alcoholic Fatty Liver Disease through Biological Interaction Networks
Andújar-Vera, International journal of molecular sciences 2023 - “...Spondin 2 314,440 28.0 6 ITGAM P11215 Integrin Subunit Alpha M 304,704 14.0 7 CEBPA P49715 CCAAT Enhancer Binding Protein Alpha 292,120 8.0 8 TGFB1 P01137 Transforming Growth Factor Beta 1 287,228 12.0 9 RUNX1 Q16285 RUNX Family Transcription Factor 1 256,626 4.0 10 EGFR Q9H2C9...”
- Andrographolide in atherosclerosis: integrating network pharmacology and in vitro pharmacological evaluation
Shi, Bioscience reports 2022 - “...Cyclin dependent kinase 2 CTD 17 P38936 CDKN1A Cyclin dependent kinase inhibitor 1A CTD 18 P49715 CEBPA CCAAT enhancer binding protein alpha CTD 19 P17676 CEBPB CCAAT enhancer binding protein beta CTD 20 Q6UWW8 CES3 Carboxylesterase 3 CTD 21 Q9NSE2 CISH Cytokine inducible SH2 containing protein...”
- High ETV6 Levels Support Aggressive B Lymphoma Cell Survival and Predict Poor Outcome in Diffuse Large B-Cell Lymphoma Patients.
Marino, Cancers 2022 - “...CCL3 4.1361 0.0105 P32248 CCR7 3.5845 <0.0001 P26842 CD27 6.0218 0.0064 P60033 CD81 7.0502 0.0006 P49715 CEBPA 4.0571 0.0527 P04141 CSF2/GMCSF 10.0918 0.0032 P29279 CTGF/IGFBP-8 7.2609 0.0138 P49961 ENTP1/CD39 4.3636 0.0176 P41212 ETV6/TEL1 1.6527 0.0017 cancers-14-00338-t003_Table 3 Table 3 Proteins selected as prognostic factors in the...”
- Trametenolic Acid B Triggers HSP90AA4P and Autophagy in HepG2/2.2.15 Cells by Proteomic Analysis.
Shi, ACS omega 2020 - “...SERPINE1 2.451743869 0.000184744 Q58FG1 HSP90AA4P 9.012655171 0.038730637 E9PQH6 RHOC 0.535146891 0.032874584 Q5EC54 HNRPK 0.555578714 0.000443851 P49715 CEBPA 0.597202485 0.024468918 J3KQ66 RELN 0.626574895 0.004123722 A0A024R4P4 ZNF444 0.630660267 0.006206777 Q562M3 ACT 0.64158601 0.011433265 P20290 BTF3 0.643345699 0.04588412 O00767 SCD 0.648399493 0.000845196 E5RGR5 C8orf59 0.650300672 0.047407105 Differential Expression Proteins...”
- Levels of human proteins in plasma associated with acute paediatric malaria.
Reuterswärd, Malaria journal 2018 - “...factor 1E 75 HPA002082+ Acute phase response CD14 P08571 CD14 molecule 6E 31 HPA001887+ CEBPA P49715 CCAAT/enhancer binding protein alpha 5E 83 HPA052734 CRP P02741 C-reactive protein 7E 109 HPA027396+ LBP P18428 Lipopolysaccharide binding protein 4E 87 HPA001508 ORM1/ORM2 P02763, P19652 Orosomucoid 1/2 5E 27 HPA047725...”
- “...Matrix metallopeptidase 9 3E02 HPA001238 Acute phase response CD14 P08571 CD14 molecule 3E02 HPA001887+ CEBPA P49715 CCAAT/enhancer binding protein alpha 3E02 HPA052734 CRP P02741 C-reactive protein 3E02 HPA027396 LBP P18428 Lipopolysaccharide binding protein 3E02 HPA001508 TNF P01375 Tumour necrosis factor 5E02 HPA077901+ Apoptosis DAPK1 P53355 Death...”
- Integrating sequence and gene expression information predicts genome-wide DNA-binding proteins and suggests a cooperative mechanism.
Ahmad, Nucleic acids research 2018 - “...annotated in PDB. This list contains several known DNA-binding proteins such as CCAAT/enhancer-binding proteins and (P49715 and P23771) and Trans -acting T-cell-specific TF GATA-3, which further supports the effectiveness of our method, because these proteins are generally missed by a standard UniProt search for the DNA-binding...”
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- A blastic plasmacytoid dendritic cell neoplasm-like immunophenotype is negatively associated with CEBPA bZIP mutation and predicts unfavorable prognosis in acute myeloid leukemia.
Song, Annals of hematology 2024 (PubMed)- GeneRIF: A blastic plasmacytoid dendritic cell neoplasm-like immunophenotype is negatively associated with CEBPA bZIP mutation and predicts unfavorable prognosis in acute myeloid leukemia.
- C/EBPα mediates the maturation and antitumor functions of macrophages in human hepatocellular carcinoma.
Wang, Cancer letters 2024 (PubMed)- GeneRIF: C/EBPalpha mediates the maturation and antitumor functions of macrophages in human hepatocellular carcinoma.
- miR-942-5p Regulates Proliferation, Invasion and EMT of Trophoblast Cells in Gestational Diabetes by Targeting the CEBPA.
Chu, Alternative therapies in health and medicine 2024 (PubMed)- GeneRIF: miR-942-5p Regulates Proliferation, Invasion and EMT of Trophoblast Cells in Gestational Diabetes by Targeting the CEBPA.
- CEBPA double mutations associated with ABO antigen weakness in hematologic diseases.
Choi, Blood advances 2024 - GeneRIF: CEBPA double mutations associated with ABO antigen weakness in hematologic diseases.
- Clinical features and management of germline CEBPA-mutated carriers.
Pan, Leukemia research 2024 (PubMed)- GeneRIF: Clinical features and management of germline CEBPA-mutated carriers.
- C/EBPα-p30 confers AML cell susceptibility to the terminal unfolded protein response and resistance to Venetoclax by activating DDIT3 transcription.
Du, Journal of experimental & clinical cancer research : CR 2024 - GeneRIF: C/EBPalpha-p30 confers AML cell susceptibility to the terminal unfolded protein response and resistance to Venetoclax by activating DDIT3 transcription.
- Targeting the nuclear long noncoding transcript LSP1P5 abrogates extracellular matrix deposition by trans-upregulating CEBPA in keloids.
Gu, Molecular therapy : the journal of the American Society of Gene Therapy 2024 - GeneRIF: Targeting the nuclear long noncoding transcript LSP1P5 abrogates extracellular matrix deposition by trans-upregulating CEBPA in keloids.
- Ring finger protein 138 inhibits transcription factor C/EBPα protein turnover leading to differentiation arrest in acute myeloid leukemia.
Singh, The Biochemical journal 2024 (PubMed)- GeneRIF: Ring finger protein 138 inhibits transcription factor C/EBPalpha protein turnover leading to differentiation arrest in acute myeloid leukemia.
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NP_001274506 CCAAT/enhancer-binding protein alpha isoform c from Rattus norvegicus
76% identity, 16% coverage
- C/EBPα involvement in microglial polarization via HDAC1/STAT3 pathway aggravated sevoflurane-induced cognitive impairment in aged rats.
Xu, PeerJ 2023 - GeneRIF: C/EBPalpha involvement in microglial polarization via HDAC1/STAT3 pathway aggravated sevoflurane-induced cognitive impairment in aged rats.
- The CEBPA-FGF21 regulatory network may participate in the T2DM-induced skeletal muscle atrophy by regulating the autophagy-lysosomal pathway.
Wu, Acta diabetologica 2023 (PubMed)- GeneRIF: The CEBPA-FGF21 regulatory network may participate in the T2DM-induced skeletal muscle atrophy by regulating the autophagy-lysosomal pathway.
- C/EBPα regulates the fate of bone marrow mesenchymal stem cells and steroid-induced avascular necrosis of the femoral head by targeting the PPARγ signalling pathway.
Duan, Stem cell research & therapy 2022 - GeneRIF: C/EBPalpha regulates the fate of bone marrow mesenchymal stem cells and steroid-induced avascular necrosis of the femoral head by targeting the PPARgamma signalling pathway.
- C/EBPα-Mediated Transcriptional Activation of PIK3C2A Regulates Autophagy, Matrix Metalloproteinase Expression, and Phenotypic of Vascular Smooth Muscle Cells in Aortic Dissection.
Lu, Journal of immunology research 2022 - GeneRIF: C/EBPalpha-Mediated Transcriptional Activation of PIK3C2A Regulates Autophagy, Matrix Metalloproteinase Expression, and Phenotypic of Vascular Smooth Muscle Cells in Aortic Dissection.
- C/EBP-α induces autophagy by binding to Beclin1 through its own acetylation modification in activated hepatic stellate cells.
Hou, Experimental cell research 2021 (PubMed)- GeneRIF: C/EBP-alpha induces autophagy by binding to Beclin1 through its own acetylation modification in activated hepatic stellate cells.
- Sumoylation of CCAAT-enhancer-binding protein α inhibits lung differentiation in Bronchopulmonary Dysplasia model rats.
Zhu, Journal of cellular and molecular medicine 2020 - GeneRIF: Sumoylation of CCAAT-enhancer-binding protein alpha inhibits lung differentiation in Bronchopulmonary Dysplasia model rats.
- C/EBPα-mediated transcriptional activation of miR-134-5p entails KPNA3 inhibition and modulates focal hypoxic-ischemic brain damage in neonatal rats.
Chen, Brain research bulletin 2020 (PubMed)- GeneRIF: C/EBPalpha-mediated transcriptional activation of miR-134-5p entails KPNA3 inhibition and modulates focal hypoxic-ischemic brain damage in neonatal rats.
- Functional roles of C/EBPα and SUMO‑modification in lung development.
Chen, International journal of molecular medicine 2017 - GeneRIF: C/EBPalpha played a role in lung development and provided the insight into the mechanism underlying SUMO-modification.
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NP_571960 CCAAT/enhancer-binding protein alpha from Danio rerio
73% identity, 22% coverage
- Genetic and epigenetic orchestration of Gfi1aa-Lsd1-cebpa in zebrafish neutrophil development.
Wu, Development (Cambridge, England) 2021 (PubMed)- GeneRIF: Genetic and epigenetic orchestration of Gfi1aa-Lsd1-cebpa in zebrafish neutrophil development.
- Cebpα is essential for the embryonic myeloid progenitor and neutrophil maintenance in zebrafish.
Dai, Journal of genetics and genomics = Yi chuan xue bao 2016 (PubMed)- GeneRIF: a new role of Cebpalpha in embryonic myelopoiesis
- DNA methyltransferase 1 functions through C/ebpa to maintain hematopoietic stem and progenitor cells in zebrafish.
Liu, Journal of hematology & oncology 2015 - GeneRIF: Dnmt1 is required for hematopoietic stem and progenitor cells maintenance via cebpa regulation during definitive hematopoiesis in zebrafish
- CCAAT/enhancer-binding protein α is required for hepatic outgrowth via the p53 pathway in zebrafish.
Yuan, Scientific reports 2015 - GeneRIF: C/ebpalpha plays a role in liver growth regulation via the p53 pathway.
- Ethanol-induced upregulation of 10-formyltetrahydrofolate dehydrogenase helps relieve ethanol-induced oxidative stress.
Hsiao, Molecular and cellular biology 2014 - GeneRIF: Data suggest that upregulation of 10-formyltetrahydrofolate dehydrogenase (FDH) involving CEBPalpha helps relieve embryonic oxidative stress induced by ethanol exposure.
- Sumoylation of CCAAT/enhancer-binding protein α promotes the biased primitive hematopoiesis of zebrafish.
Yuan, Blood 2011 (PubMed)- GeneRIF: Results provide first evidence that sumoylation of Cebp-alpha (via SUMO1, SUMO2, and SUMO3) might contribute to cell fate decision of myelo-erythroid progenitor cells in intermediate cell mass during primitive [extramedullary] hematopoiesis.
- Dominant-negative C/ebpα and polycomb group protein Bmi1 extend short-lived hematopoietic stem/progenitor cell life span and induce lethal dyserythropoiesis.
Zhou, Blood 2011 (PubMed)- GeneRIF: Bmi1 acts immediately downstream of CCAAT enhancer binding protein-alpha to regulate the survival and self-renewal of hematopoietic stem cells and contribute to the erythropoietic dysplasia.
- An evolutionarily conserved PTEN-C/EBPalpha-CTNNA1 axis controls myeloid development and transformation.
Fu, Blood 2010 - GeneRIF: An evolutionarily conserved PTEN-C/EBPalpha-CTNNA1 axis controls myeloid development and transformation.
CEBPE_HUMAN / Q15744 CCAAT/enhancer-binding protein epsilon; C/EBP epsilon from Homo sapiens (Human) (see 9 papers)
NP_001796 CCAAT/enhancer-binding protein epsilon from Homo sapiens
76% identity, 22% coverage
- function: Transcriptional activator (PubMed:26019275). C/EBP are DNA- binding proteins that recognize two different motifs: the CCAAT homology common to many promoters and the enhanced core homology common to many enhancers. Required for the promyelocyte-myelocyte transition in myeloid differentiation (PubMed:10359588).
subunit: Binds DNA as a homodimer and as a heterodimer (PubMed:26019275). Can form stable heterodimers with CEBPA, CEBPB and CEBPD (By similarity). Interacts with GATA1 and SPI1 (PubMed:26019275). Interacts with SMARCD2 (PubMed:28369036). - ARID5B, IKZF1, GATA3, CEBPE, and CDKN2A germline polymorphisms and predisposition to childhood acute lymphoblastic leukemia.
Al-Zayan, Pediatric hematology and oncology 2024 (PubMed)- GeneRIF: ARID5B, IKZF1, GATA3, CEBPE, and CDKN2A germline polymorphisms and predisposition to childhood acute lymphoblastic leukemia.
- Significance of CEBPE Gene Promoter Polymorphism (Rs2239630 G > A ) Assessment in Childhood B-cell Acute Lymphoblastic Leukemia.
Aref, Journal of pediatric hematology/oncology 2023 (PubMed)- GeneRIF: Significance of CEBPE Gene Promoter Polymorphism (Rs2239630 G > A) Assessment in Childhood B-cell Acute Lymphoblastic Leukemia.
- The CEBPE rs2239633 genetic polymorphism on susceptibility to childhood acute lymphoblastic leukemia: an updated meta-analysis.
Liu, Environmental health and preventive medicine 2021 - GeneRIF: The CEBPE rs2239633 genetic polymorphism on susceptibility to childhood acute lymphoblastic leukemia: an updated meta-analysis.
- Loss of myeloid-specific lamin A/C drives lung metastasis through Gfi-1 and C/EBPε-mediated granulocytic differentiation.
Ishii, Molecular carcinogenesis 2020 - GeneRIF: Loss of myeloid-specific lamin A/C drives lung metastasis through Gfi-1 and C/EBPepsilon-mediated granulocytic differentiation.
- Identification and genomic analysis of pedigrees with exceptional longevity identifies candidate rare variants.
Miller, Neurobiology of disease 2020 - GeneRIF: Identification and genomic analysis of pedigrees with exceptional longevity identifies candidate rare variants.
- Genetic predisposition to B-cell acute lymphoblastic leukemia at 14q11.2 is mediated by a CEBPE promoter polymorphism.
Studd, Leukemia 2019 - GeneRIF: CEBPE promoter polymorphism is associated with B-cell acute lymphoblastic leukemia.
- CEBPE expression is an independent prognostic factor for acute myeloid leukemia.
Li, Journal of translational medicine 2019 - GeneRIF: CEBPE expression was an independent prognostic factor for Acute Myeloid Leukemia survival, relapse and allogeneic transplantation, which will provide useful information for outcome prediction and therapeutic decisions.
- Gain-of-function CEBPE mutation causes noncanonical autoinflammatory inflammasomopathy.
Göös, The Journal of allergy and clinical immunology 2019 - GeneRIF: this study shows that gain-of-function CEBPE mutation causes noncanonical autoinflammatory inflammasomopathy
- More
- Structural basis for specific DNA sequence recognition by the transcription factor NFIL3.
Chen, The Journal of biological chemistry 2024 - “...Q16534); DBP (UniProt: Q10586); C/EBP (UniProt: P49715); C/EBP (UniProt: P17676); C/EBP (UniProt: P49716); C/EBP (UniProt: Q15744); C/EBP (UniProt: P53567); C/EBP (UniProt: P35638). bZIP: basic region-leucine zipper domain. The phylogenetic tree was generated using the amino acid sequences of the bZIP domain by MEGA11 ( 63 )....”
- The zinc proteome of SARS-CoV-2
Andreini, Metallomics : integrated biometal science 2022 - “...sapiens DPH3 homolog (Q96FX2) Nsp3 H2399, C2404, C2409, C2412 3t92_3 Homo sapiens CCAAT/enhancer-binding protein epsilon (Q15744) Nsp10 C4327, C4330, C4336, C4343 3mhs_2 Saccharomyces cerevisiae b Ubiquitin carboxyl-terminal hydrolase 8 (P50102) Nsp10 C4370, C4373, C4381, C4383 2ctu_1 Homo sapiens Zinc finger protein 483 (Q8TF39) Nsp13 C5329, H5332,...”
- iTRAQ-based quantitative proteomic analysis provides insight for molecular mechanism of neuroticism.
Tian, Clinical proteomics 2019 - “...Myeloperoxidase 1.74 3.18E10** A2J1N6 Rheumatoid factor RF-ET9 1.23 0.03918** B2MUD5 ELA2 Neutrophil elastase 2.05 3.34E09** Q15744 CEBPE CCAAT/enhancer-binding protein epsilon 0.79 5.47E09** P04438 Ig heavy chain V-II region SESS 1.68 2.01E05** P14780 MMP9 Matrix metalloproteinase-9 1.87 1.61E07** Q93079 HIST1H2BH Histone H2B type 1-H 4.31 3.00E14** S6BGD4...”
CEBPA_MOUSE / P53566 CCAAT/enhancer-binding protein alpha; C/EBP alpha from Mus musculus (Mouse) (see 17 papers)
NP_031704 CCAAT/enhancer-binding protein alpha isoform a from Mus musculus
76% identity, 17% coverage
- function: Transcription factor that coordinates proliferation arrest and the differentiation of myeloid progenitors, adipocytes, hepatocytes, and cells of the lung and the placenta (PubMed:15107404, PubMed:15589173, PubMed:36228616, PubMed:8415748). Binds directly to the consensus DNA sequence 5'-T[TG]NNGNAA[TG]-3' acting as an activator on distinct target genes. During early embryogenesis, plays essential and redundant functions with CEBPB (PubMed:15509779). Essential for the transition from common myeloid progenitors (CMP) to granulocyte/monocyte progenitors (GMP) (PubMed:24367003). Critical for the proper development of the liver and the lung (PubMed:8798745). Necessary for terminal adipocyte differentiation, is required for postnatal maintenance of systemic energy homeostasis and lipid storage (PubMed:1935900, PubMed:8090719). To regulate these different processes at the proper moment and tissue, interplays with other transcription factors and modulators. Down-regulates the expression of genes that maintain cells in an undifferentiated and proliferative state through E2F1 repression, which is critical for its ability to induce adipocyte and granulocyte terminal differentiation. Reciprocally E2F1 blocks adipocyte differentiation by binding to specific promoters and repressing CEBPA binding to its target gene promoters (PubMed:11672531). Proliferation arrest also depends on a functional binding to SWI/SNF complex (PubMed:14660596). In liver, regulates gluconeogenesis and lipogenesis through different mechanisms. To regulate gluconeogenesis, functionally cooperates with FOXO1 binding to IRE-controlled promoters and regulating the expression of target genes such as PCK1 or G6PC1 (PubMed:17627282). To modulate lipogenesis, interacts and transcriptionally synergizes with SREBF1 in promoter activation of specific lipogenic target genes such as ACAS2 (PubMed:17290224). In adipose tissue, seems to act as FOXO1 coactivator accessing to ADIPOQ promoter through FOXO1 binding sites (PubMed:17090532).
function: [Isoform 3]: Can act as dominant-negative. Binds DNA and have transctivation activity, even if much less efficiently than isoform 2. Does not inhibit cell proliferation.
function: [Isoform 4]: Directly and specifically enhances ribosomal DNA transcription interacting with RNA polymerase I-specific cofactors and inducing histone acetylation.
subunit: Binds DNA as a homodimer and as a heterodimer. Can form stable heterodimers with CEBPB, CEBPD, CEBPE and CEBPG (By similarity). Interacts with PRDM16 (PubMed:19641492). Interacts with UBN1 (By similarity). Interacts with ZNF638; this interaction increases transcriptional activation (PubMed:21602272). Interacts with the complex TFDP2:E2F1; the interaction prevents CEBPA binding to target gene promoters and represses its transcriptional activity (By similarity). Interacts with RB1 (PubMed:15107404). Interacts (when phosphorylated at Ser-193) with CDK2, CDK4, E2F4 and SMARCA2 (PubMed:15107404). Interacts with SREBPF1 (PubMed:17290224). Interacts with FOXO1 (via the Fork-head domain); the interaction increases when FOXO1 is deacetylated (PubMed:17090532, PubMed:17627282). Interacts with SIX1 (PubMed:27923061). Interacts (via recognition sequence) with TRIB1 (By similarity). Interacts (via bZIP domain) with OVOL2 (via zinc-finger domains); the interaction inhibits the transcription factor activity of CEBPA and is required to repress adipogenesis (PubMed:36228616).
subunit: [Isoform 1]: Interacts with TAF1A and UBTF.
subunit: [Isoform 4]: Interacts with TAF1A and UBTF (By similarity). Interacts with NPM1 (By similarity).
disruption phenotype: Mutants die of hypoglycemia at 7-10 hours after birth. They have defects in the control of hepatic growth and lung development. The liver architecture is disturbed with acinar formation. They show hyperproliferation of type II pneumocytes and disturbed alveolar architecture. At the molecular level, accumulation of glycogen and lipids in the liver and adipose tissues is impaired, and the mutant animals are severely hypoglycemic (PubMed:8798745). In very few cases (less than 1%) mutants are able to survive up to 4 weeks but they are sevrely retarded in development. At 2 weeks, they are about half the size of their littermates, very thin and with skin problems. Conditional knockout in adults leads to a lack of granulopoiesis in all hematopoietic organs with no mature peripheral blood granulocytes and the presence of >30% immature myeloid cells in the bone marrow, but without anemia or thrombocytopenia. Animals rarely survive 4 to 5 weeks of age due to sepsis as a result of granulocytopenia (PubMed:15589173). Double knockout CEBPA and CEBPB results in embryonic developmental arrest and death at around 10 dpc to 11 dpc, associated with a gross placenta failure (PubMed:15509779). - An intronic enhancer of Cebpa regulates adipocyte differentiation and adipose tissue development via long-range loop formation.
Li, Cell proliferation 2024 - GeneRIF: An intronic enhancer of Cebpa regulates adipocyte differentiation and adipose tissue development via long-range loop formation.
- C/EBPα alleviates hepatic ischemia-reperfusion injury by inhibiting endoplasmic reticulum stress via HDAC1-mediated deacetylation of ATF4.
Li, Journal of biochemical and molecular toxicology 2024 (PubMed)- GeneRIF: C/EBPalpha alleviates hepatic ischemia-reperfusion injury by inhibiting endoplasmic reticulum stress via HDAC1-mediated deacetylation of ATF4.
- C/EBPα aggravates renal fibrosis in CKD through the NOX4-ROS-apoptosis pathway in tubular epithelial cells.
Xia, Biochimica et biophysica acta. Molecular basis of disease 2024 (PubMed)- GeneRIF: C/EBPalpha aggravates renal fibrosis in CKD through the NOX4-ROS-apoptosis pathway in tubular epithelial cells.
- C/EBPα-p30 confers AML cell susceptibility to the terminal unfolded protein response and resistance to Venetoclax by activating DDIT3 transcription.
Du, Journal of experimental & clinical cancer research : CR 2024 - GeneRIF: C/EBPalpha-p30 confers AML cell susceptibility to the terminal unfolded protein response and resistance to Venetoclax by activating DDIT3 transcription.
- Transcription factor C/EBPα is required for the development of Ly6Chi monocytes but not Ly6Clo monocytes.
Kim, Proceedings of the National Academy of Sciences of the United States of America 2024 - GeneRIF: Transcription factor C/EBPalpha is required for the development of Ly6C[hi] monocytes but not Ly6C[lo] monocytes.
- CEBPA restricts alveolar type 2 cell plasticity during development and injury-repair.
Hassan, Nature communications 2024 - GeneRIF: CEBPA restricts alveolar type 2 cell plasticity during development and injury-repair.
- Targeting CEBPA to restore cellular identity and tissue homeostasis in pulmonary fibrosis.
Tan, JCI insight 2024 - GeneRIF: Targeting CEBPA to restore cellular identity and tissue homeostasis in pulmonary fibrosis.
- CEBPα/miR-101b-3p promotes meningoencephalitis in mice infected with Angiostrongylus cantonensis by promoting microglial pyroptosis.
Zeng, Cell communication and signaling : CCS 2023 - GeneRIF: CEBPalpha/miR-101b-3p promotes meningoencephalitis in mice infected with Angiostrongylus cantonensis by promoting microglial pyroptosis.
- More
- Adipose-specific overexpression of human AGPAT2 in mice causes increased adiposity and mild hepatic dysfunction.
Agarwal, iScience 2024 - “...SIITLDGGALVQVQK [8397] 2071 14 1.00 0.53 2790 18 1.00 1.27 2216 17 1.00 0.88 Cebp P53566 TGGGGGGSGAGAGK [261274]; VLELTSDNDR [315324] 1 1 1.00 0.36 4 2 1.00 1.14 1 1 1.00 0.99 Perilipin 1 Q8CGN5 ETAEYAANTR [159168] 172 31 1.00 0.84 171 29 1.00 0.94 329...”
- Regulated adipose tissue-specific expression of human AGPAT2 in lipodystrophic Agpat2-null mice results in regeneration of adipose tissue.
Agarwal, iScience 2023 - “...SIITLDGGALVQVQK [8397] 2071 14 1.00 0.16* 2790 18 1.00 0.59 2216 17 1.00 0.34$ Cebp P53566 TGGGGGGSGAGAGK [261274] ; VLELTSDNDR [315324] 1 1 1.00 0.23 4 2 1.00 0.56 1 1 1.00 0.34* Perilipin 1 Q8CGN5 ETAEYAANTR [159168] 172 31 1.00 0.38 171 29 1.00 1.24...”
- Proteomic analysis of 3T3-L1 preadipocytes having a higher cell proliferation rate after treatment with low-molecular-weight silk fibroin peptides
Huang, Cell proliferation 2010 (secret) - Proteomic analysis of interchromatin granule clusters.
Saitoh, Molecular biology of the cell 2004
XP_016888138 CCAAT/enhancer-binding protein alpha from Cynoglossus semilaevis
70% identity, 19% coverage
8k8cA / P49715 Crystal structure of c/ebpalpha bzip domain bound to a high affinity DNA (see paper)
79% identity, 94% coverage
NP_789741 CCAAT/enhancer-binding protein alpha from Bos taurus
76% identity, 18% coverage
- ACOX1, regulated by C/EBPα and miR-25-3p, promotes bovine preadipocyte adipogenesis.
Zhang, Journal of molecular endocrinology 2021 - GeneRIF: ACOX1, regulated by C/EBPalpha and miR-25-3p, promotes bovine preadipocyte adipogenesis.
- Investigation of high correlation with carcass traits of SNPs of the PLCB1, C/EBPα, and TDRKH genes and the combinations of SNPs using the MDR method in the Hanwoo.
Kim, Genes & genomics 2021 (PubMed)- GeneRIF: Investigation of high correlation with carcass traits of SNPs of the PLCB1, C/EBPalpha, and TDRKH genes and the combinations of SNPs using the MDR method in the Hanwoo.
- Effect of genetic variation of CEBPA gene on body measurement and carcass traits of Qinchuan cattle.
He, Molecular biology reports 2011 (PubMed)- GeneRIF: These results suggest that the CEBPA gene is a strong candidate gene that affects carcass traits in Qinchuan cattle.
- Influence of different feeding systems on the growth performance and muscle development of Japanese Black steers.
Shibata, Meat science 2011 (PubMed)- GeneRIF: Expressions of C-EBPalpha and myostatin in muscles were higher in the concentrate-fed group than in the grass hay-fed group.
CEBPD_HUMAN / P49716 CCAAT/enhancer-binding protein delta; C/EBP delta; Nuclear factor NF-IL6-beta; NF-IL6-beta from Homo sapiens (Human) (see paper)
NP_005186 CCAAT/enhancer-binding protein delta from Homo sapiens
68% identity, 23% coverage
- function: Transcription activator that recognizes two different DNA motifs: the CCAAT homology common to many promoters and the enhanced core homology common to many enhancers (PubMed:16397300). Important transcription factor regulating the expression of genes involved in immune and inflammatory responses (PubMed:16397300, PubMed:1741402). Transcriptional activator that enhances IL6 transcription alone and as heterodimer with CEBPB (PubMed:1741402).
subunit: Binds DNA as a homodimer and as a heterodimer (PubMed:1741402). Can form stable heterodimers with CEBPB (PubMed:1741402). Can form stable heterodimers with CEBPA and CEBPE. Directly interacts with SPI1/PU.1; this interaction does not affect DNA-binding properties of each partner. Interacts with PRDM16. - Inhibition of MMP8 effectively alleviates manic-like behavior and reduces neuroinflammation by modulating astrocytic CEBPD.
Wang, Journal of neuroinflammation 2024 - GeneRIF: Inhibition of MMP8 effectively alleviates manic-like behavior and reduces neuroinflammation by modulating astrocytic CEBPD.
- CCAAT enhancer binding protein delta activates vesicle associated membrane protein 3 transcription to enhance chemoresistance and extracellular PD-L1 expression in triple-negative breast cancer.
Zhao, Journal of experimental & clinical cancer research : CR 2024 - GeneRIF: CCAAT enhancer binding protein delta activates vesicle associated membrane protein 3 transcription to enhance chemoresistance and extracellular PD-L1 expression in triple-negative breast cancer.
- Systematic transcriptome profiling of hPSC-derived osteoblasts unveils CORIN's mastery in governing osteogenesis through CEBPD modulation.
Zhu, The Journal of biological chemistry 2024 - GeneRIF: Systematic transcriptome profiling of hPSC-derived osteoblasts unveils CORIN's mastery in governing osteogenesis through CEBPD modulation.
- C/EBP-Family Redundancy Determines Patient Survival and Lymph Node Involvement in PDAC.
Hartl, International journal of molecular sciences 2023 - GeneRIF: C/EBP-Family Redundancy Determines Patient Survival and Lymph Node Involvement in PDAC.
- CCAAT/enhancer binding protein (C/EBP) delta promotes the expression of PTX3 and macrophage phagocytosis during A. fumigatus infection.
Liu, Journal of leukocyte biology 2022 (PubMed)- GeneRIF: CCAAT/enhancer binding protein (C/EBP) delta promotes the expression of PTX3 and macrophage phagocytosis during A. fumigatus infection.
- Angiogenesis Driven by the CEBPD-hsa-miR-429-VEGFA Signaling Axis Promotes Urothelial Carcinoma Progression.
Chan, Cells 2022 - GeneRIF: Angiogenesis Driven by the CEBPD-hsa-miR-429-VEGFA Signaling Axis Promotes Urothelial Carcinoma Progression.
- C/EBPδ Suppresses Motility-Associated Gene Signatures and Reduces PDAC Cell Migration.
Hartl, Cells 2022 - GeneRIF: C/EBPdelta Suppresses Motility-Associated Gene Signatures and Reduces PDAC Cell Migration.
- C/EBPδ drives key endocrine signals in the human amnion at parturition.
Lu, Clinical and translational medicine 2021 - GeneRIF: C/EBPdelta drives key endocrine signals in the human amnion at parturition.
- More
- Structural basis for specific DNA sequence recognition by the transcription factor NFIL3.
Chen, The Journal of biological chemistry 2024 - “...Q10587); HLF (UniProt: Q16534); DBP (UniProt: Q10586); C/EBP (UniProt: P49715); C/EBP (UniProt: P17676); C/EBP (UniProt: P49716); C/EBP (UniProt: Q15744); C/EBP (UniProt: P53567); C/EBP (UniProt: P35638). bZIP: basic region-leucine zipper domain. The phylogenetic tree was generated using the amino acid sequences of the bZIP domain by MEGA11...”
- Identification of Blood Biomarkers for Alzheimer's Disease Through Computational Prediction and Experimental Validation.
Yao, Frontiers in neurology 2018 - “...interacting protein ITPRIP Q9UQE7 Structural maintenance of chromosomes protein 3 SMC3 P25774 Cathepsin S CTSS P49716 CCAAT/enhancer-binding protein delta CEBPD Q9Y2G2 Caspase recruitment domain-containing protein 8 CARD8 P36894 Bone morphogenetic protein receptor type-1A BMPR1A P49755 Transmembrane emp24 domain-containing protein 10 TMED10 Q9Y2J8 Protein-arginine deiminase type-2 PADI2...”
- The Chromatin Assembly Factor Complex 1 (CAF1) and 5-Azacytidine (5-AzaC) Affect Cell Motility in Src-transformed Human Epithelial Cells.
Endo, The Journal of biological chemistry 2017 - “...P98179 RBM3 Putative RNA-binding protein 3 1.052 0.034 Q9ULX9 MAFF Transcription factor MafF 1.042 0.022 P49716 CEBPD CCAAT/enhancer-binding protein delta 1.039 0.006 Q14676 MDC1 Mediator of DNA damage checkpoint protein 1.005 0.005 Proteins up-regulated upon 4-OHT treatment P14618 PKM2 Pyruvate kinase isozymes M1/M2 1.376 0.023 P78371...”
CEBPD_RAT / Q03484 CCAAT/enhancer-binding protein delta; C/EBP delta; Transcription factor CELF from Rattus norvegicus (Rat) (see paper)
NP_037286 CCAAT/enhancer-binding protein delta from Rattus norvegicus
68% identity, 23% coverage
- function: Transcription activator that recognizes two different DNA motifs: the CCAAT homology common to many promoters and the enhanced core homology common to many enhancers (PubMed:1714459). Important transcription factor regulating the expression of genes involved in immune and inflammatory responses. Transcriptional activator that enhances IL6 transcription alone and as heterodimer with CEBPB (By similarity).
subunit: Binds DNA as a homodimer and as a heterodimer. Can form stable heterodimers with CEBPA, CEBPB and CEBPE. Directly interacts with SPI1/PU.1; this interaction does not affect DNA-binding properties of each partner. Interacts with PRDM16. - CEBPD aggravates apoptosis and oxidative stress of neuron after ischemic stroke by Nrf2/HO-1 pathway.
Chen, Experimental cell research 2024 (PubMed)- GeneRIF: CEBPD aggravates apoptosis and oxidative stress of neuron after ischemic stroke by Nrf2/HO-1 pathway.
- Transcription factors Tp73, Cebpd, Pax6, and Spi1 rather than DNA methylation regulate chronic transcriptomics changes after experimental traumatic brain injury.
Lipponen, Acta neuropathologica communications 2018 - GeneRIF: Four upregulated transcription factors Pax6, Tp73, Cebpd, and Spi1, appeared as potent regulators of chronic post-traumatic brain injury (TBI) gene expression. They regulate molecular networks contributing to post-injury secondary damage, including apoptosis and inflammation, strengthening the feasibility of therapeutically targeting these molecular networks even after the acute post-TBI period.
- Androgen receptor activation integrates complex transcriptional effects in osteoblasts, involving the growth factors TGF-β and IGF-I, and transcription factor C/EBPδ.
McCarthy, Gene 2015 (PubMed)- GeneRIF: DHT activated AR inhibits gene transactivation by C/EBPdelta, and transgenic C/EBPdelta expression inhibits AR activity
- CCAAT enhancer binding protein δ plays an essential role in memory consolidation and reconsolidation.
Arguello, The Journal of neuroscience : the official journal of the Society for Neuroscience 2013 - GeneRIF: C/EBPdelta plays a critical role in both memory consolidation and reconsolidation.
- The transcription factor C/EBP delta has anti-apoptotic and anti-inflammatory roles in pancreatic beta cells.
Moore, PloS one 2012 - GeneRIF: novel function of C/EBPdelta as a modulatory transcription factor that inhibits the pro-apoptotic and pro-inflammatory gene networks activated by cytokines in pancreatic beta-cells.
- Changes of CCAAT enhancer-binding proteins (CEBPs) in the lung of streptozotocin-induced diabetic rats.
Fong, Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme 2011 (PubMed)- GeneRIF: Increase of plasma glucose is related to the lower expression of C/EBPbeta and C/EBPdelta proteins in the lung of STZ-diabetic rats.
- The CCAAT/enhancer binding protein (C/EBP) δ is differently regulated by fibrillar and oligomeric forms of the Alzheimer amyloid-β peptide.
Ramberg, Journal of neuroinflammation 2011 - GeneRIF: These data suggest that both expression and function of C/EBPdelta are dysregulated in Alzheimer's disease.
- CEBPD suppresses prolactin expression and prolactinoma cell proliferation.
Tong, Molecular endocrinology (Baltimore, Md.) 2011 - GeneRIF: The results show that PRL expression and cell proliferation are controlled in part by CEBPD.
- More
CEBPE_RAT / P56261 CCAAT/enhancer-binding protein epsilon; C/EBP epsilon; C/EBP-related protein 1 from Rattus norvegicus (Rat) (see paper)
73% identity, 22% coverage
- function: Transcriptional activator. C/EBP are DNA-binding proteins that recognize two different motifs: the CCAAT homology common to many promoters and the enhanced core homology common to many enhancers. Required for the promyelocyte-myelocyte transition in myeloid differentiation.
subunit: Binds DNA as a homodimer and as a heterodimer. Can form stable heterodimers with CEBPA, CEBPB and CEBPD (PubMed:1884998). Interacts with GATA1 and SPI1 (By similarity). Interacts with SMARCD2 (By similarity).
NP_997014 CCAAT/enhancer-binding protein epsilon from Mus musculus
73% identity, 22% coverage
- Identification of a novel enhancer of CEBPE essential for granulocytic differentiation.
Shyamsunder, Blood 2019 (PubMed)- GeneRIF: we have identified a novel enhancer crucial for regulating expression of Cebpe and required for normal granulocytic differentiation
- Deficiency of CCAAT/enhancer binding protein-epsilon reduces atherosclerotic lesions in LDLR-/- mice.
Okamoto, PloS one 2014 - GeneRIF: study suggests that the myeloid specific factor C/EBPepsilon is involved in systemic lipid metabolism and that silencing of C/EBPepsilon could decrease the development of atherosclerosis.
- C/EBPepsilon directs granulocytic-vs-monocytic lineage determination and confers chemotactic function via Hlx.
Halene, Experimental hematology 2010 - GeneRIF: in the absence of CCAAT enhancer binding protein epsilon (C/EBPepsilon), there is not only incomplete differentiation of granulocytes, but myelopoiesis is disrupted and neutrophils have abnormal chemotaxis
- In vivo deficiency of both C/EBPβ and C/EBPε results in highly defective myeloid differentiation and lack of cytokine response.
Akagi, PloS one 2010 - GeneRIF: Data show that macrophages from bbee compared to single knockout mice revealed decreased expression of essential immune response-related genes and networks.
- Phosphorylation of PML is essential for activation of C/EBP epsilon and PU.1 to accelerate granulocytic differentiation.
Tagata, Leukemia 2008 (PubMed)- GeneRIF: Phosphorylation of PML was required for stimulating C/EBP epsilon-dependent transcription and accelerating C/EBP epsilon-induced granulocytic differentiation.
- The lamin B receptor under transcriptional control of C/EBPepsilon is required for morphological but not functional maturation of neutrophils.
Cohen, Human molecular genetics 2008 - GeneRIF: Lbr, under transcriptional regulation of C/EBPepsilon, is necessary for morphological but not necessarily functional granulocyte
- Expression of bactericidal/permeability-increasing protein requires C/EBP epsilon.
Tanaka, International journal of hematology 2007 (PubMed)- GeneRIF: the requirement for C/EBP epsilon in mediating BPI gene expression in myeloid cells in vitro and in vivo.
- PML-retinoic acid receptor alpha inhibits PML IV enhancement of PU.1-induced C/EBPepsilon expression in myeloid differentiation.
Yoshida, Molecular and cellular biology 2007 - GeneRIF: The type IV isoform of PML interacted with PU.1, promoted its association with p300, and then enhanced PU.1-induced transcription and granulocytic differentiation and PU.1 directly activates the transcription of the C/EBPepsilon gene.
- More
CEBPD_MOUSE / Q00322 CCAAT/enhancer-binding protein delta; C/EBP delta; C/EBP-related protein 3 from Mus musculus (Mouse) (see 3 papers)
NP_031705 CCAAT/enhancer-binding protein delta from Mus musculus
68% identity, 23% coverage
- function: Transcription activator that recognizes two different DNA motifs: the CCAAT homology common to many promoters and the enhanced core homology common to many enhancers (PubMed:19641492, PubMed:7594592). Important transcription factor regulating the expression of genes involved in immune and inflammatory responses. Transcriptional activator that enhances IL6 transcription alone and as heterodimer with CEBPB (By similarity).
subunit: Binds DNA as a homodimer and as a heterodimer. Can form stable heterodimers with CEBPA, CEBPB and CEBPE (PubMed:1884998). Directly interacts with SPI1/PU.1; this interaction does not affect DNA-binding properties of each partner (PubMed:7594592). Interacts with PRDM16 (PubMed:19641492). - Norbergenin prevents LPS-induced inflammatory responses in macrophages through inhibiting NFκB, MAPK and STAT3 activation and blocking metabolic reprogramming.
Li, Frontiers in immunology 2023 - “...C domain-containing protein 1 -1.914 Down Ptgs2 Q05769 Prostaglandin G/H synthase 2 -2.469 Down Cebpd Q00322 CCAAT/enhancer-binding protein delta -1.263 Down Cdkn1A P39689 Cyclin-dependent kinase inhibitor 1 -0.908 Down Icam1 P13597 Intercellular adhesion molecule 1 -1.082 Down Cebpb P28033 CCAAT/enhancer-binding protein beta -1.082 Down Cxcl10 P17515...”
- Proteomic analysis of 3T3-L1 preadipocytes having a higher cell proliferation rate after treatment with low-molecular-weight silk fibroin peptides
Huang, Cell proliferation 2010 (secret) - Inhibition of MMP8 effectively alleviates manic-like behavior and reduces neuroinflammation by modulating astrocytic CEBPD.
Wang, Journal of neuroinflammation 2024 - GeneRIF: Inhibition of MMP8 effectively alleviates manic-like behavior and reduces neuroinflammation by modulating astrocytic CEBPD.
- PPA1 promotes adipogenesis by regulating the stability of C/EBPs.
Wu, Cell death and differentiation 2024 - GeneRIF: PPA1 promotes adipogenesis by regulating the stability of C/EBPs.
- C/EBPδ Mediates Immunity to Renal Autoinflammatory Disorders in a Stage-specific Manner.
Dey, Journal of immunology (Baltimore, Md. : 1950) 2024 - GeneRIF: C/EBPdelta Mediates Immunity to Renal Autoinflammatory Disorders in a Stage-specific Manner.
- Hypoxia Abrogates Tumor-Suppressive Activities of C/EBPδ in Pancreatic Cancer.
Hartl, International journal of molecular sciences 2024 - GeneRIF: Hypoxia Abrogates Tumor-Suppressive Activities of C/EBPdelta in Pancreatic Cancer.
- CEBPD REGULATES OXIDATIVE STRESS AND INFLAMMATORY RESPONSES IN HYPERTENSIVE CARDIAC REMODELING.
Zhao, Shock (Augusta, Ga.) 2023 (PubMed)- GeneRIF: CEBPD REGULATES OXIDATIVE STRESS AND INFLAMMATORY RESPONSES IN HYPERTENSIVE CARDIAC REMODELING.
- FOXO1 cooperates with C/EBPδ and ATF4 to regulate skeletal muscle atrophy transcriptional program during fasting.
Oyabu, FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2022 (PubMed)- GeneRIF: FOXO1 cooperates with C/EBPdelta and ATF4 to regulate skeletal muscle atrophy transcriptional program during fasting.
- C/EBPδ-induced epigenetic changes control the dynamic gene transcription of S100a8 and S100a9.
Jauch-Speer, eLife 2022 - GeneRIF: C/EBPdelta-induced epigenetic changes control the dynamic gene transcription of S100a8 and S100a9.
- Activation of the β-adrenergic receptor exacerbates lipopolysaccharide-induced wasting of skeletal muscle cells by increasing interleukin-6 production.
Matsukawa, PloS one 2021 - GeneRIF: Activation of the beta-adrenergic receptor exacerbates lipopolysaccharide-induced wasting of skeletal muscle cells by increasing interleukin-6 production.
- More
CEBPD_SHEEP / Q9N0J3 CCAAT/enhancer-binding protein delta; C/EBP delta from Ovis aries (Sheep) (see paper)
69% identity, 24% coverage
- function: Transcription activator that recognizes two different DNA motifs: the CCAAT homology common to many promoters and the enhanced core homology common to many enhancers (PubMed:10799300). Important transcription factor regulating the expression of genes involved in immune and inflammatory responses. Transcriptional activator that enhances IL6 transcription alone and as heterodimer with CEBPB (By similarity).
subunit: Binds DNA as a homodimer and as a heterodimer. Can form stable heterodimers with CEBPA, CEBPB and CEBPE. Directly interacts with SPI1/PU.1; this interaction does not affect DNA-binding properties of each partner. Interacts with PRDM16.
XP_027828734 CCAAT/enhancer-binding protein delta from Ovis aries
69% identity, 24% coverage
NP_776692 CCAAT/enhancer-binding protein delta from Bos taurus
70% identity, 23% coverage
NP_001083076 CCAAT/enhancer binding protein delta L homeolog from Xenopus laevis
68% identity, 22% coverage
B9ENT4 CCAAT/enhancer-binding protein from Salmo salar
65% identity, 20% coverage
CEBPG_MOUSE / P53568 CCAAT/enhancer-binding protein gamma; C/EBP gamma; Granulocyte colony-stimulating factor promoter element 1-binding protein; GPE1-BP; GPE1-binding protein; Immunoglobulin enhancer-binding protein 1; IG/EBP-1 from Mus musculus (Mouse) (see 3 papers)
NP_034014 CCAAT/enhancer-binding protein gamma from Mus musculus
54% identity, 41% coverage
- function: Transcription factor that binds to the promoter and the enhancer regions of target genes (PubMed:21602272). Binds to the promoter and the enhancer of the immunoglobulin heavy chain (PubMed:2121606). Binds to GPE1, a cis-acting element in the G-CSF gene promoter (PubMed:1709121). Binds to the enhancer element PRE-I (positive regulatory element-I) of the IL-4 gene (By similarity). Binds to the promoter and the enhancer of the alpha-1-fetoprotein gene (By similarity).
subunit: Binds DNA as a dimer and can form stable heterodimers with CEBPA (PubMed:2121606). Can form stable heterodimers with CEBPB (By similarity). Interacts with ZNF638; this interaction increases transcriptional activation (PubMed:21602272). - CEBPG suppresses ferroptosis through transcriptional control of SLC7A11 in ovarian cancer.
Zhang, Journal of translational medicine 2023 - GeneRIF: CEBPG suppresses ferroptosis through transcriptional control of SLC7A11 in ovarian cancer.
- Systemic approaches using single cell transcriptome reveal that C/EBPγ regulates autophagy under amino acid starved condition.
Kim, Nucleic acids research 2022 - GeneRIF: Systemic approaches using single cell transcriptome reveal that C/EBPgamma regulates autophagy under amino acid starved condition.
- Co-expression of C/EBPγ and ATF5 in mouse vomeronasal sensory neurons during early postnatal development.
Nakano, Cell and tissue research 2019 (PubMed)- GeneRIF: The results suggest the role of C/EBPgamma on ATF5 (activating transcription factor 5)-regulated vomeronasal sensory neurons differentiation in early postnatal development.
- C/EBPγ is dispensable for steady-state and emergency granulopoiesis.
Kardosova, Haematologica 2018 - GeneRIF: specific deletion of Cebpg in the murine hematopoietic system did not alter hematopoietic stem and progenitor cell properties, their ability to commit to the myeloid lineage, and produce granulocytes in normal and stress conditions.
- C/EBPγ Is a Critical Regulator of Cellular Stress Response Networks through Heterodimerization with ATF4.
Huggins, Molecular and cellular biology 2015 - GeneRIF: Adult Cebpg-/- mice on a mixed strain background show increased early mortality and altered cancer incidence.
- C/EBPγ suppresses senescence and inflammatory gene expression by heterodimerizing with C/EBPβ.
Huggins, Molecular and cellular biology 2013 - GeneRIF: The senescence-suppressing activity of C/EBPgamma required its ability to heterodimerize with C/EBPbeta.
- HIV-1 Tat-mediated induction of CCL5 in astrocytes involves NF-κB, AP-1, C/EBPα and C/EBPγ transcription factors and JAK, PI3K/Akt and p38 MAPK signaling pathways.
Nookala, PloS one 2013 - GeneRIF: HIV-1 Tat-mediated induction of CCL5 in astrocytes involves NF-kappaB, AP-1, C/EBPalpha and C/EBPgamma transcription factors and JAK, PI3K/Akt and p38 MAPK signaling pathways
- CCAAT/enhancer-binding protein γ is a critical regulator of IL-1β-induced IL-6 production in alveolar epithelial cells.
Yan, PloS one 2012 - GeneRIF: CCAAT/enhancer-binding protein gamma is a critical regulator of IL-1beta-induced IL-6 production in alveolar epithelial cells.
CEBPG_HUMAN / P53567 CCAAT/enhancer-binding protein gamma; C/EBP gamma from Homo sapiens (Human) (see paper)
NP_001797 CCAAT/enhancer-binding protein gamma from Homo sapiens
54% identity, 41% coverage
- function: Transcription factor that binds to the promoter and the enhancer regions of target genes. Binds to the enhancer element PRE-I (positive regulatory element-I) of the IL-4 gene (PubMed:7665092). Binds to the promoter and the enhancer of the immunoglobulin heavy chain. Binds to GPE1, a cis-acting element in the G-CSF gene promoter.
subunit: Binds DNA as a dimer and can form stable heterodimers with CEBPA and CEBPB. Interacts with ZNF638; this interaction increases transcriptional activation. - C/EBP-Family Redundancy Determines Patient Survival and Lymph Node Involvement in PDAC.
Hartl, International journal of molecular sciences 2023 - GeneRIF: C/EBP-Family Redundancy Determines Patient Survival and Lymph Node Involvement in PDAC.
- C/EBPγ is a critical negative regulator of LPS-/IgG immune complex-induced acute lung injury through the downregulation of C/EBPβ-/C/EBPδ-dependent C/EBP transcription activation.
Yan, FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2020 (PubMed)- GeneRIF: C/EBPgamma is a critical negative regulator of LPS-/IgG immune complex-induced acute lung injury through the downregulation of C/EBPbeta-/C/EBPdelta-dependent C/EBP transcription activation.
- Genetic signatures of heroin addiction.
Chen, Medicine 2016 - GeneRIF: The study aimed to identify a small set of genetic signatures that may reliably predict the individuals with a high genetic propensity to heroin addiction. A set of 4 genes (JUN, CEBPB, PRKCB, ENO2, or CEBPG) could predict the diagnosis of heroin addiction with the accuracy rate around 85% in our dataset.
- B-cell precursor acute lymphoblastic leukemia with isolated t(14;19)(q32;q13) abnormality involving the CEBPG gene.
Haghi, Leukemia & lymphoma 2015 (PubMed)- GeneRIF: These findings suggest that CEBPG may play an oncogenic role in BCP-ALL and relies on a mechanism different from CEBPA.
- C/EBPγ suppresses senescence and inflammatory gene expression by heterodimerizing with C/EBPβ.
Huggins, Molecular and cellular biology 2013 - GeneRIF: High CEBPG expression correlated with poorer clinical prognoses in several human cancers, and C/EBP gamma depletion decreased proliferation and induced senescence in lung tumor cells.
- HIV-1 Tat-mediated induction of CCL5 in astrocytes involves NF-κB, AP-1, C/EBPα and C/EBPγ transcription factors and JAK, PI3K/Akt and p38 MAPK signaling pathways.
Nookala, PloS one 2013 - GeneRIF: HIV-1 Tat-mediated induction of CCL5 in astrocytes involves NF-kappaB, AP-1, C/EBPalpha and C/EBPgamma transcription factors and JAK, PI3K/Akt and p38 MAPK signaling pathways
- C/EBPγ regulates wound repair and EGF receptor signaling.
Melchionna, The Journal of investigative dermatology 2012 (PubMed)- GeneRIF: C/EBPgamma positively regulates wound repair both in vitro and in vivo, at least in part, by affecting EGFR signaling.
- C/EBPγ deregulation results in differentiation arrest in acute myeloid leukemia.
Alberich-Jordà, The Journal of clinical investigation 2012 - GeneRIF: CEBPG mediates the myeloid differentiation arrest induced by CEBPA deficiency in acute myeloid leukemia.
- More
- Structural basis for specific DNA sequence recognition by the transcription factor NFIL3.
Chen, The Journal of biological chemistry 2024 - “...Q10586); C/EBP (UniProt: P49715); C/EBP (UniProt: P17676); C/EBP (UniProt: P49716); C/EBP (UniProt: Q15744); C/EBP (UniProt: P53567); C/EBP (UniProt: P35638). bZIP: basic region-leucine zipper domain. The phylogenetic tree was generated using the amino acid sequences of the bZIP domain by MEGA11 ( 63 ). NFIL3, TEF, HLF,...”
- Automatic Text-Mining Approach to Identify Molecular Target Candidates Associated with Metabolic Processes for Myotonic Dystrophy Type 1
Kuntawala, International journal of environmental research and public health 2023 - “...breast cancer and causes mutations in different human malignancies. 38 [ 57 , 74 ] P53567 CEBPG CCAAT/enhancer-binding protein gamma mRNA metabolic process, positive regulation of DNA binding and repair - Potential biomarkers for cancer prognosis. - Plays a role in gastric cancer progression and breast...”
- Global Lysine Acetylome Analysis of LPS-Stimulated HepG2 Cells Identified Hyperacetylation of PKM2 as a Metabolic Regulator in Sepsis.
Na, International journal of molecular sciences 2021 - “...3 Nucleoside diphosphate kinase Q32Q12 NME1-NME2 _FEQK(ac)GFR_ 100.19 K56 2 3.05 4 CCAAT/enhancer-binding protein gamma P53567 CEBPG _AVAPSK(ac)QSK_ 104.89 K50 2 2.75 5 Aldo-keto reductase family 1 member C3 P42330 AKR1C3 _SK(ac)IADGSVK_ 72.2 K68 2 2.63 6 Heterogeneous nuclear ribonucleoprotein U A0A1 7SBS1 HNRNPU _K(ac)AEVEGKDLPEHAVLK_ 68.751...”
CEBPG_RAT / P26801 CCAAT/enhancer-binding protein gamma; C/EBP gamma from Rattus norvegicus (Rat) (see paper)
54% identity, 41% coverage
- function: Transcription factor that binds to the promoter and the enhancer regions of target genes. Binds to the promoter and the enhancer of the alpha-1-fetoprotein gene (PubMed:1377818). Binds to the enhancer element PRE-I (positive regulatory element-I) of the IL-4 gene (By similarity). Binds to the promoter and the enhancer of the immunoglobulin heavy chain. Binds to GPE1, a cis-acting element in the G-CSF gene promoter (By similarity).
subunit: Binds DNA as a dimer and can form stable heterodimers with CEBPA and CEBPB (PubMed:1377818). Interacts with ZNF638; this interaction increases transcriptional activation (By similarity).
LOC105668437 CCAAT/enhancer-binding protein from Linepithema humile
61% identity, 18% coverage
- Social environment affects the transcriptomic response to bacteria in ant queens
Viljakainen, Ecology and evolution 2018 - “...1.15E02 LOC105674248 Branchedchainamino acid aminotransferase 1.35 2.78E05 8.59E03 LOC105680007 Protein toll (LOC105680007) 1.35 2.01E06 1.18E03 LOC105668437 CCAAT/enhancerbinding protein (LOC105668437) 1.33 1.81E04 3.35E02 LOC105675016 Peroxidaselike (LOC105675016) 1.27 7.08E04 9.94E02 LOC105677240 General odorantbinding protein 56dlike (LOC105677240) 1.18 1.06E04 2.33E02 LOC105677283 Alphaaminoadipic semialdehyde synthase 1.14 4.72E04 7.52E02 LOC105671238 Exosome...”
LOC105661976 LOW QUALITY PROTEIN: CCAAT/enhancer-binding protein-like from Megachile rotundata
61% identity, 24% coverage
- Immediate Transcriptional Response to a Temperature Pulse under a Fluctuating Thermal Regime
Melicher, Integrative and comparative biology 2019 - “...SIK3-like XM_003699760 LOC100880515 Bone morphogenetic protein receptor type-1B XM_012282783 LOC100881489 Nuclear hormone receptor FTZ-F1 XM_012281076 LOC105661976 CCAAT/enhancer-binding protein-like 2017Down in FTR XM_012288926 LOC100880270 Transmembrane protease serine 9-like XM_003700471 LOC100877574 Elongation of very long chain fatty acids protein 7-like XM_003703558 LOC100878819 Fatty acid synthase XM_003700398 LOC100878398 Heparan-alpha-glucosaminide...”
NP_571912 CCAAT/enhancer binding protein (C/EBP) 1 from Danio rerio
54% identity, 36% coverage
WP_062270874 CCAAT/enhancer-binding protein from Endozoicomonas arenosclerae
45% identity, 27% coverage
- Nach Is a Novel Subgroup at an Early Evolutionary Stage of the CNC-bZIP Subfamily Transcription Factors from the Marine Bacteria to Humans
Zhu, International journal of molecular sciences 2018 - “...of human C/EBP and its homologous protein from marine bacteria (with the GenBank accession No. WP_062270874) is determined ( Figure S1c ); both also share an evolutionary stem with Skn-1 (as a member of the CNC-bZIP subfamily) ( Figure 1 c and Figure S15 ). Two...”
- “...from marine bacteria to humans, the sequence conservation of Nach and other bacterial bZIP homologues (WP_062270874 and KRG21159) with human equivalents has been clearly established ( Figure 2 , Figures S1, S3S5, and S15 ), but is, by itself, a mystery, and therefore, it is interesting...”
CEBP2_CAEEL / Q8IG69 CCAAT/enhancer-binding protein homolog 2 from Caenorhabditis elegans (see 4 papers)
NP_871835 CCAAT/enhancer-binding protein homolog 2 from Caenorhabditis elegans
48% identity, 60% coverage
- function: Transcription factor that binds to the promoter and the enhancer regions of target genes (By similarity). Regulates expression of genes involved in fat metabolism, including ech-1.1 and fat-5 (PubMed:26505800). Has a protective role in response to infection by the Gram-negative bacterium P.aeruginosa (PubMed:26876169, PubMed:28662060, PubMed:34804026). Required for the activation of infection response gene irg-1 following P.aeruginosa infection (PubMed:26876169). Required to prevent P.aeruginosa ToxA-mediated lethality (PubMed:26876169). May also function in concert with transcription factor zip-11 to mediate immune responses, independently of the pmk-1/p38 MAPK pathway (PubMed:34804026). May act together with the bZIP transcription factor, zip-2 (PubMed:26876169).
subunit: Interacts with transcription factor zip-11.
disruption phenotype: RNAi-mediated knockdown reduces overall fat content (PubMed:26505800). Decreases survival upon infection with P.aeruginosa (PubMed:26876169, PubMed:28662060). Reduces induction of expression of infection response gene, irg-1, in response to P.aeruginosa (PubMed:26876169). The decrease in survival upon P.aeruginosa infection on a zip-11 mutant background is abolished by RNAi-mediated knockdown of cebp-2. - The C. elegans CCAAT-Enhancer-Binding Protein Gamma Is Required for Surveillance Immunity.
Reddy, Cell reports 2016 - GeneRIF: Cebp-2 is required for infection response gene induction upon Pseudomonas aeruginosa Infection.
- CCAAT/enhancer-binding protein CEBP-2 controls fat consumption and fatty acid desaturation in Caenorhabditis elegans.
Xu, Biochemical and biophysical research communications (PubMed)- GeneRIF: cebp-2 controls total body fat content by governing fatty acid mitochondrial beta-oxidation and desaturation in C. elegans.
NP_001037102 ovary C/EBPg transcription factor from Bombyx mori
52% identity, 53% coverage
NP_001037374 chorion specific C/EBP from Bombyx mori
54% identity, 22% coverage
LOC105380784 CCAAT/enhancer-binding protein from Plutella xylostella
52% identity, 22% coverage
LOC100122625 uncharacterized protein LOC100122625 from Nasonia vitripennis
41% identity, 11% coverage
LOC101898926 CCAAT/enhancer-binding protein from Musca domestica
44% identity, 14% coverage
For advice on how to use these tools together, see
Interactive tools for functional annotation of bacterial genomes.
The PaperBLAST database links 798,070 different protein sequences to 1,261,478 scientific articles. Searches against EuropePMC were last performed on May 12 2025.
PaperBLAST builds a database of protein sequences that are linked
to scientific articles. These links come from automated text searches
against the articles in EuropePMC
and from manually-curated information from GeneRIF, UniProtKB/Swiss-Prot,
BRENDA,
CAZy (as made available by dbCAN),
BioLiP,
CharProtDB,
MetaCyc,
EcoCyc,
TCDB,
REBASE,
the Fitness Browser,
and a subset of the European Nucleotide Archive with the /experiment tag.
Given this database and a protein sequence query,
PaperBLAST uses protein-protein BLAST
to find similar sequences with E < 0.001.
To build the database, we query EuropePMC with locus tags, with RefSeq protein
identifiers, and with UniProt
accessions. We obtain the locus tags from RefSeq or from MicrobesOnline. We use
queries of the form "locus_tag AND genus_name" to try to ensure that
the paper is actually discussing that gene. Because EuropePMC indexes
most recent biomedical papers, even if they are not open access, some
of the links may be to papers that you cannot read or that our
computers cannot read. We query each of these identifiers that
appears in the open access part of EuropePMC, as well as every locus
tag that appears in the 500 most-referenced genomes, so that a gene
may appear in the PaperBLAST results even though none of the papers
that mention it are open access. We also incorporate text-mined links
from EuropePMC that link open access articles to UniProt or RefSeq
identifiers. (This yields some additional links because EuropePMC
uses different heuristics for their text mining than we do.)
For every article that mentions a locus tag, a RefSeq protein
identifier, or a UniProt accession, we try to select one or two
snippets of text that refer to the protein. If we cannot get access to
the full text, we try to select a snippet from the abstract, but
unfortunately, unique identifiers such as locus tags are rarely
provided in abstracts.
PaperBLAST also incorporates manually-curated protein functions:
- Proteins from NCBI's RefSeq are included if a
GeneRIF
entry links the gene to an article in
PubMed®.
GeneRIF also provides a short summary of the article's claim about the
protein, which is shown instead of a snippet.
- Proteins from Swiss-Prot (the curated part of UniProt)
are included if the curators
identified experimental evidence for the protein's function (evidence
code ECO:0000269). For these proteins, the fields of the Swiss-Prot entry that
describe the protein's function are shown (with bold headings).
- Proteins from BRENDA,
a curated database of enzymes, are included if they are linked to a paper in PubMed
and their full sequence is known.
- Every protein from the non-redundant subset of
BioLiP,
a database
of ligand-binding sites and catalytic residues in protein structures, is included. Since BioLiP itself
does not include descriptions of the proteins, those are taken from the
Protein Data Bank.
Descriptions from PDB rely on the original submitter of the
structure and cannot be updated by others, so they may be less reliable.
(For SitesBLAST and Sites on a Tree, we use a larger subset of BioLiP so that every
ligand is represented among a group of structures with similar sequences, but for
PaperBLAST, we use the non-redundant set provided by BioLiP.)
- Every protein from EcoCyc, a curated
database of the proteins in Escherichia coli K-12, is included, regardless
of whether they are characterized or not.
- Proteins from the MetaCyc metabolic pathway database
are included if they are linked to a paper in PubMed and their full sequence is known.
- Proteins from the Transport Classification Database (TCDB)
are included if they have known substrate(s), have reference(s),
and are not described as uncharacterized or putative.
(Some of the references are not visible on the PaperBLAST web site.)
- Every protein from CharProtDB,
a database of experimentally characterized protein annotations, is included.
- Proteins from the CAZy database of carbohydrate-active enzymes
are included if they are associated with an Enzyme Classification number.
Even though CAZy does not provide links from individual protein sequences to papers,
these should all be experimentally-characterized proteins.
- Proteins from the REBASE database
of restriction enzymes are included if they have known specificity.
- Every protein with an evidence-based reannotation (based on mutant phenotypes)
in the Fitness Browser is included.
- Sequence-specific transcription factors (including sigma factors and DNA-binding response regulators)
with experimentally-determined DNA binding sites from the
PRODORIC database of gene regulation in prokaryotes.
- Putative transcription factors from RegPrecise
that have manually-curated predictions for their binding sites. These predictions are based on
conserved putative regulatory sites across genomes that contain similar transcription factors,
so PaperBLAST clusters the TFs at 70% identity and retains just one member of each cluster.
- Coding sequence (CDS) features from the
European Nucleotide Archive (ENA)
are included if the /experiment tag is set (implying that there is experimental evidence for the annotation),
the nucleotide entry links to paper(s) in PubMed,
and the nucleotide entry is from the STD data class
(implying that these are targeted annotated sequences, not from shotgun sequencing).
Also, to filter out genes whose transcription or translation was detected, but whose function
was not studied, nucleotide entries or papers with more than 25 such proteins are excluded.
Descriptions from ENA rely on the original submitter of the
sequence and cannot be updated by others, so they may be less reliable.
Except for GeneRIF and ENA,
the curated entries include a short curated
description of the protein's function.
For entries from BioLiP, the protein's function may not be known beyond binding to the ligand.
Many of these entries also link to articles in PubMed.
For more information see the
PaperBLAST paper (mSystems 2017)
or the code.
You can download PaperBLAST's database here.
Changes to PaperBLAST since the paper was written:
- November 2023: incorporated PRODORIC and RegPrecise. Many PRODORIC entries were not linked to a protein sequence (no UniProt identifier), so we added this information.
- February 2023: BioLiP changed their download format. PaperBLAST now includes their non-redundant subset. SitesBLAST and Sites on a Tree use a larger non-redundant subset that ensures that every ligand is represented within each cluster. This should ensure that every binding site is represented.
- June 2022: incorporated some coding sequences from ENA with the /experiment tag.
- March 2022: incorporated BioLiP.
- April 2020: incorporated TCDB.
- April 2019: EuropePMC now returns table entries in their search results. This has expanded PaperBLAST's database, but most of the new entries are of low relevance, and the resulting snippets are often just lists of locus tags with annotations.
- February 2018: the alignment page reports the conservation of the hit's functional sites (if available from from Swiss-Prot or UniProt)
- January 2018: incorporated BRENDA.
- December 2017: incorporated MetaCyc, CharProtDB, CAZy, REBASE, and the reannotations from the Fitness Browser.
- September 2017: EuropePMC no longer returns some table entries in their search results. This has shrunk PaperBLAST's database, but has also reduced the number of low-relevance hits.
Many of these changes are described in Interactive tools for functional annotation of bacterial genomes.
PaperBLAST cannot provide snippets for many of the papers that are
published in non-open-access journals. This limitation applies even if
the paper is marked as "free" on the publisher's web site and is
available in PubmedCentral or EuropePMC. If a journal that you publish
in is marked as "secret," please consider publishing elsewhere.
Many important articles are missing from PaperBLAST, either because
the article's full text is not in EuropePMC (as for many older
articles), or because the paper does not mention a protein identifier such as a locus tag, or because of PaperBLAST's heuristics. If you notice an
article that characterizes a protein's function but is missing from
PaperBLAST, please notify the curators at UniProt
or add an entry to GeneRIF.
Entries in either of these databases will eventually be incorporated
into PaperBLAST. Note that to add an entry to UniProt, you will need
to find the UniProt identifier for the protein. If the protein is not
already in UniProt, you can ask them to create an entry. To add an
entry to GeneRIF, you will need an NCBI Gene identifier, but
unfortunately many prokaryotic proteins in RefSeq do not have
corresponding Gene identifers.
References
PaperBLAST: Text-mining papers for information about homologs.
M. N. Price and A. P. Arkin (2017). mSystems, 10.1128/mSystems.00039-17.
Europe PMC in 2017.
M. Levchenko et al (2017). Nucleic Acids Research, 10.1093/nar/gkx1005.
Gene indexing: characterization and analysis of NLM's GeneRIFs.
J. A. Mitchell et al (2003). AMIA Annu Symp Proc 2003:460-464.
UniProt: the universal protein knowledgebase.
The UniProt Consortium (2016). Nucleic Acids Research, 10.1093/nar/gkw1099.
BRENDA in 2017: new perspectives and new tools in BRENDA.
S. Placzek et al (2017). Nucleic Acids Research, 10.1093/nar/gkw952.
The EcoCyc database: reflecting new knowledge about Escherichia coli K-12.
I. M. Keeseler et al (2016). Nucleic Acids Research, 10.1093/nar/gkw1003.
The MetaCyc database of metabolic pathways and enzymes.
R. Caspi et al (2018). Nucleic Acids Research, 10.1093/nar/gkx935.
CharProtDB: a database of experimentally characterized protein annotations.
R. Madupu et al (2012). Nucleic Acids Research, 10.1093/nar/gkr1133.
The carbohydrate-active enzymes database (CAZy) in 2013.
V. Lombard et al (2014). Nucleic Acids Research, 10.1093/nar/gkt1178.
The Transporter Classification Database (TCDB): recent advances
M. H. Saier, Jr. et al (2016). Nucleic Acids Research, 10.1093/nar/gkv1103.
REBASE - a database for DNA restriction and modification: enzymes, genes and genomes.
R. J. Roberts et al (2015). Nucleic Acids Research, 10.1093/nar/gku1046.
Deep annotation of protein function across diverse bacteria from mutant phenotypes.
M. N. Price et al (2016). bioRxiv, 10.1101/072470.
by Morgan Price,
Arkin group
Lawrence Berkeley National Laboratory