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DUFs with Characterized Representatives

These 606 PFams are annotated as domains of unknown function, yet they contain at least one protein that has been curated and appears to be characterized. These families may be good targets for curation or for biochemical study.

For each family, we show up to 20 characterized representatives. (Characterized members are excluded if they contain other domains that are characterized.) We also show the annotation of the PFam in InterPro, because sometimes a DUF has a more specific annotation in InterPro. And we show the overlapping families (if any) from the Conserved Domains Database. DUFs with the most papers about them are shown first.

Last updated on Nov. 15, 2018

DUF3652 (PF12372.8): Huntingtin protein region (41 a.a.), 713 papers
IPR024613: Huntingtin_middle-repeat. This repeated domain is less than 40 amino acids in length and is associated with the huntingtin protein. The protein is of unknown function, however it is known that an expansion of a polyglutamine (CAG) repeat in the gene coding for it results in the development of Huntington's disease.

Members of DUF3652 whose function may be known:

DUF3399 (PF11879.8): Domain of unknown function (DUF3399) (104 a.a.), 248 papers
IPR024587: K_chnl_volt-dep_Kv4_C. Potassium channels are the most diverse group of the ion channel family. They are important in shaping the action potential, and in neuronal excitability and plasticity. The potassium channel family is composed of several functionally distinct isoforms, which can be broadly separated into 2 groups: the practically non-inactivating 'delayed' group and the rapidly inactivating 'transient' group. These are all...

Members of DUF3399 whose function may be known:

UPF0020 (PF01170.18): Putative RNA methylase family UPF0020 (197 a.a.), 201 papers
IPR000241: RNA_methylase_dom. This domain is probably a methylase. It is associated with the THUMP domain that also occurs with RNA modification domains.
Overlapping families in CDD: AdoMet_MTases superfamily, N6_N4_Mtase, RlmL, TIGR01177, Trm11, Trm11 superfamily

Members of UPF0020 whose function may be known:

DUF21 (PF01595.20): Cyclin M transmembrane N-terminal domain (176 a.a.), 171 papers
IPR002550: CNNM. Proteins containing the ancient conserved domain protein/cyclin M (CNNM) are integral membrane proteins that are conserved from bacteria to humans. CNNM family members influence metal ion homeostasis through mechanisms that may not involve direct membrane transport of the ions. Structurally, CNNMs are complex proteins that contain an extracellular N-terminal domain preceding a transmembrane domain, a "Bateman module", which consists...
Overlapping families in CDD: CBS_pair superfamily, CBS_pair_CorC_HlyC_assoc, CorC_HlyC superfamily, GldE, PRK15094, TlyC

Members of DUF21 whose function may be known:

UPF0051 (PF01458.17): Uncharacterized protein family (UPF0051) (218 a.a.), 144 papers
IPR000825: SUF_FeS_clus_asmbl_SufBD. Iron-sulphur (FeS) clusters are important cofactors for numerous proteins involved in electron transfer, in redox and non-redox catalysis, in gene regulation, and as sensors of oxygen and iron. These functions depend on the various FeS cluster prosthetic groups, the most common being [2Fe-2S] and [4Fe-4S]. FeS cluster assembly is a complex process involving the mobilisation of Fe and S...
Overlapping families in CDD: PRK10948, PRK11814, SufB, sufB, sufD

Members of UPF0051 whose function may be known:

DUF836 (PF05768.14): Glutaredoxin-like domain (DUF836) (82 a.a.), 142 papers
IPR008554: Glutaredoxin-like. Glutaredoxins, also known as thioltransferases (disulphide reductases, are small proteins of approximately one hundred amino-acid residues which utilise glutathione and NADPH as cofactors. Oxidized glutathione is regenerated by glutathione reductase. Together these components compose the glutathione system. Glutaredoxin functions as an electron carrier in the glutathione-dependent synthesis of deoxyribonucleotides by the enzyme ribonucleotide reductase. Like thioredoxin (TRX), which functions...
Overlapping families in CDD: PHA03075, PHA03075 superfamily, Thioredoxin_like superfamily

Members of DUF836 whose function may be known:

DUF676 (PF05057.14): Putative serine esterase (DUF676) (219 a.a.), 119 papers
IPR007751: DUF676_lipase-like. This domain, whose function is unknown, is found within a group of putative lipases. Proteins containing this domain include YOR059C (Lpl1) from budding yeasts. Lpl1 has been identified as a phospholipase B.
Overlapping families in CDD: Abhydrolase superfamily

Members of DUF676 whose function may be known:

DUF758 (PF05527.11): Domain of unknown function (DUF758) (181 a.a.), 109 papers
IPR008477: TNFAIP8-like. Four tumor necrosis factor alpha-induced protein 8-like proteins have been identified: TNFAIP8 (also known as TIPE), TIPE1, TIPE2 and TIPE3. Overexpressed TIPE in cells can reduce cell death in vitro and increase tumor growth in vivo. By contrast, TIPE2 has been demonstrated to be an inhibitor of Ras and to have a pro-apoptotic ability. TIPE1 could upregulate the pro-apoptotic...

Members of DUF758 whose function may be known:

DUF1752 (PF08550.10): Fungal protein of unknown function (DUF1752) (28 a.a.), 106 papers
IPR013860: AreA_GATA. This entry represents fungal proteins containing GATA domains, including nitrogen regulatory protein areA, a transcription activator that binds the consensus DNA element 5'-CGATAG-3' and mediates nitrogen metabolite repression. The entry also contains that is thought to be a negative regulator of RAS-cAMP pathway in S. cerevisiae and the S. pombe member is a GAF1 transcription factor .

Members of DUF1752 whose function may be known:

DUF1471 (PF07338.13): Protein of unknown function (DUF1471) (56 a.a.), 94 papers
IPR010854: DUF1471. This entry consists of several hypothetical Enterobacterial proteins of around 90 residues in length. Some of the proteins are annotated as ydgH precursors and contain two copies of this region, one at the N terminus and the other at the C terminus. The function of this family is unknown.
Overlapping families in CDD: PRK09929, PRK10259, PRK14864

Members of DUF1471 whose function may be known:

DUF3585 (PF12130.8): Bivalent Mical/EHBP Rab binding domain (136 a.a.), 84 papers
IPR022735: bMERB_dom. A variety of different effector proteins interact specifically with GTP-bound Rab proteins and mediate their versatile roles in membrane trafficking, including budding of vesicles from a donor membrane, directed transport through the cell and finally tethering and fusion with a target membrane. The "bivalent Mical/EHBP Rab binding" (bMERB) domain is a Rab effector domain that is present in proteins...
Overlapping families in CDD: FinO_conjug_rep superfamily, GBP_C, GBP_C superfamily, Neuromodulin_N superfamily, PRK03918, PTZ00121, ProQ, SMC_N superfamily, SMC_prok_B, SbcC, Smc

Members of DUF3585 whose function may be known:

DUF1241 (PF06840.11): Protein of unknown function (DUF1241) (150 a.a.), 83 papers

Members of DUF1241 whose function may be known:

DUF4939 (PF16297.5): Domain of unknown function (DUF4939) (112 a.a.), 82 papers
IPR032549: DUF4939. This domain is found in some members of the Mart (mammalian retrotransposon-derived) family, including LDOC1/Mart7, LDOC1L/Mart6, RTL1/Mart1, PEG10/Mart2, FAM127/Cxx1/Mart8, ZCCHC5/Mart3 and RGAG4/Mart5. Its function is not known.
Overlapping families in CDD: Atrophin-1 superfamily, Neisseria_TspB, Neisseria_TspB superfamily, PHA03247, PRK06847, PRK06847 superfamily, UBQ superfamily, rad23

Members of DUF4939 whose function may be known:

DUF3456 (PF11938.8): TLR4 regulator and MIR-interacting MSAP (156 a.a.), 74 papers
IPR021852: DUF3456. This presumed domain is functionally uncharacterised. It is found in a number of proteins, including protein canopy homologues and CRELD1 and 2.

Members of DUF3456 whose function may be known:

DUF4683 (PF15735.5): Domain of unknown function (DUF4683) (400 a.a.), 73 papers
IPR032757: DUF4683. This domain is found in eukaryotes, and is typically between 384 and 400 amino acids in length.
Overlapping families in CDD: DNA_pol3_gamma3 superfamily, PRK12323

Members of DUF4683 whose function may be known:

SIMPL (PF04402.14): Protein of unknown function (DUF541) (200 a.a.), 71 papers
IPR007497: DUF541. Members of this family have been found in bacteria, archaea and animals. A mouse family member has been named SIMPL (signalling molecule that associates with mouse pelle-like kinase). SIMPL appears to facilitate and/or regulate complex formation between IRAK/mPLK (IL-1 receptor-associated kinase) and IKK (inhibitor of kappa-B kinase) containing complexes, and thus regulate NF-kappa-B activity. Separate experiments demonstrate that a...
Overlapping families in CDD: PRK11087, YggE

Members of SIMPL whose function may be known:

DUF732 (PF05305.14): Protein of unknown function (DUF732) (95 a.a.), 70 papers
IPR007969: DUF732. This entry represents several uncharacterised Mycobacterium tuberculosis proteins of unknown function.

Members of DUF732 whose function may be known:

DUF4704 (PF15787.5): Domain of unknown function (DUF4704) (279 a.a.), 70 papers
IPR031570: DUF4704. This domain of unknown function can be found in neurobeachin proteins from eukaryotes.

Members of DUF4704 whose function may be known:

DUF2781 (PF10914.8): Protein of unknown function (DUF2781) (147 a.a.), 69 papers

Members of DUF2781 whose function may be known:

DUF971 (PF06155.12): Protein of unknown function (DUF971) (85 a.a.), 65 papers
IPR010376: GBH-like_N. This domain is found in gamma-butyrobetaine dioxygenase, Fe-S cluster assembly factor HCF101 and trimethyllysine dioxygenase proteins. Gamma-butyrobetaine hydroxylase (GBBH) is a alpha-ketoglutarate-dependent dioxygenase that catalyzes the biosynthesis of L-carnitine by hydroxylation of gamma-butyrobetaine (GBB). GBBH is a dimeric enzyme. The monomer consists of a catalytic double-stranded beta-helix domain and a smaller N-terminal domain. The N-terminal domain has a bound...
Overlapping families in CDD: COG3536

Members of DUF971 whose function may be known:

UPF0054 (PF02130.17): Uncharacterized protein family UPF0054 (128 a.a.), 62 papers
IPR002036: YbeY. YbeY is a single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA. It acts together with the RNase R to eliminate defective 70S ribosomes, but not properly matured 70S ribosomes or individual subunits, by a process mediated specifically by the 30S ribosomal subunit. It is involved in...
Overlapping families in CDD: PRK00016, TIGR00043, YbeY

Members of UPF0054 whose function may be known:

DUF1011 (PF06237.12): Protein of unknown function (DUF1011) (99 a.a.), 60 papers
IPR009357: Riboflavin_transptr. This entry includes a group of animal riboflavin transporters, including SLC52A1, SLC52A2 and SLC52A3 from humans. They are plasma membrane proteins that transport vitamin B2 (riboflavin, RF) into cells. In case of infection by retroviruses, they act as cell receptors to retroviral envelopes similar to the porcine endogenous retrovirus (PERV-A).

Members of DUF1011 whose function may be known:

DUF1205 (PF06722.12): Protein of unknown function (DUF1205) (95 a.a.), 58 papers
IPR010610: DUF1205. This entry represents a conserved region of unknown function within bacterial glycosyl transferases. Many proteins containing this domain are members of the glycosyl transferase family 28 .
Overlapping families in CDD: GT1_Gtf_like, Glycosyltransferase_GTB_type superfamily, PRK13609, PRK13609 superfamily, UDPGT superfamily, YjiC, glycosyl_450act

Members of DUF1205 whose function may be known:

DUF218 (PF02698.17): DUF218 domain (131 a.a.), 57 papers
IPR003848: DUF218. This domain contains several highly conserved charged amino acids, suggesting this may be an enzymatic domain. It is found in Escherichia coli YdcF, which has been shown to bind S-adenosyl-L-methionine (AdoMet), but whose biochemical function has not been identified. It is also found in Escherichia coli SanA and Salmonella typhimurium SfiX, which are involved in vancomycin resistance. SfiX may...
Overlapping families in CDD: PRK10494, PRK10834, SanA, YdcF, YdcF-like, YdcF-like superfamily

Members of DUF218 whose function may be known:

DUF1100 (PF06500.11): Alpha/beta hydrolase of unknown function (DUF1100) (411 a.a.), 57 papers
IPR010520: UPF0255. Family UPF0255 includes FrsA, a decarboxylase found to have the alpha/beta-hydrolase fold. FrsA converts pyruvate to acetaldehyde and carbon dioxide in a cofactor-independent manner, and shows no hydrolytic activity. It also includes the hydrolytic polyketide shortening protein Ayg1 from fungi, and Fus2 from Gibberella species, which is part of the gene cluster that mediates the biosynthesis of the mycotoxin...
Overlapping families in CDD: Abhydrolase superfamily, FrsA, FrsA superfamily, frsA

Members of DUF1100 whose function may be known:

DUF2428 (PF10350.9): Putative death-receptor fusion protein (DUF2428) (275 a.a.), 56 papers
IPR019442: DUF2428_death-receptor-like. This domain is found in a family of proteins of unknown function that are conserved from plants to humans. Several of these proteins have been annotated as being HEAT repeat-containing proteins while others are designated as death-receptor interacting proteins, but neither of these has yet been confirmed. Aberrations in the genes encoding these proteins have been observed in benign...
Overlapping families in CDD: COG5543

Members of DUF2428 whose function may be known:

DUF4174 (PF13778.6): Domain of unknown function (DUF4174) (120 a.a.), 53 papers
IPR025232: DUF4174. This domain of unknown function is found in a putative tumour suppressor gene and in a ligand for the the urokinase-type plasminogen activator receptor, which plays a role in cellular migration and adhesion.
Overlapping families in CDD: Atrophin-1 superfamily, Mucin, Mucin superfamily, PHA03247

Members of DUF4174 whose function may be known:

DUF3223 (PF11523.8): Protein of unknown function (DUF3223) (75 a.a.), 52 papers

Members of DUF3223 whose function may be known:

DUF296 (PF03479.15): Plants and Prokaryotes Conserved (PCC) domain (107 a.a.), 51 papers
IPR005175: PPC_dom. The Plants and Prokaryotes Conserved (PPC) domain contains a hydrophobic region in the C-terminal, and in the case of plants, is often found in several proteins with the AT-hook motif. Proteins with PPC domains are found in Bacteria, Archaea and the plant kingdom. The PPC domain has a single alpha-helix packed against an antiparallel beta- sheet, which is formed...
Overlapping families in CDD: COG1661

Members of DUF296 whose function may be known:

Cas_Cas4 (PF01930.17): Domain of unknown function DUF83 (162 a.a.), 50 papers
IPR022765: Dna2/Cas4_DUF83. This entry represents an uncharacterised domain found in several proteins, including DNA replication helicase Dna2, clustered regularly interspaced short palindromic repeats (CRISPR)-associated exonuclease Cas4 and putative RecB family exonuclease proteins. Dna2 is a DNA replication factor with single-stranded DNA-dependent ATPase, ATP-dependent nuclease, (5'-flap endonuclease) and helicase activities. Cas4 has been shown to be a 5' to 3' single stranded...
Overlapping families in CDD: Cas4, Cas4_I-A_I-B_I-C_I-D_II-B, Cas4_I-A_I-B_I-C_I-D_II-B superfamily, PHA00619, cas4

Members of Cas_Cas4 whose function may be known:

UPF0016 (PF01169.19): Uncharacterized protein family UPF0016 (75 a.a.), 49 papers
IPR001727: Gdt1. Budding yeast Gdt1 is a Golgi-localized calcium transporter required for stress-induced calcium signalling and protein glycosylation. Its human homologue, TMEM165, may be a Golgi Ca2(+)/H(+) antiporter. Defects in the human protein TMEM165 cause a subtype of Congenital Disorders of Glycosylation. In Arabidopsis , this protein is variously known as CCHA1 (a chloroplast-localized potential Ca(2+)/H(+) antiporter), chloroplastic PAM71 (photosynthesis affected...
Overlapping families in CDD: Gdt1

Members of UPF0016 whose function may be known:

MAF_flag10 (PF01973.18): Protein of unknown function DUF115 (171 a.a.), 49 papers
IPR002826: MptE-like. The archaeal members of this family are known to represent a 6-hydroxymethylpterin diphosphokinase (6-HMDPK), known as MptE, which catalyses the formation of 6-hydroxymethyl-7,8-dihydropterin diphosphate (6-HMDP) from 6-HMD and ATP. 6-HMDP is the precursor of the pterin containing moiety of the essential C1-carriers tetrahydrofolate and tetrahydromethanopterin. The family also includes a number of uncharacterised proteins from bacteria.
Overlapping families in CDD: COG1634, Succ_DH_flav_C superfamily, TPK, TPK superfamily, TPK_B1_binding superfamily, sdhA, thi_PPkinase

Members of MAF_flag10 whose function may be known:

DUF5051 (PF16473.5): 3' exoribonuclease, RNase T-like (166 a.a.), 49 papers
IPR033390: Rv2179c-like. This entry represents a domain found in a group of divergent 3' exoribonucleases. The proteins constitute a typical RNase fold, where the active site residues form a magnesium catalytic centre. The protein of the solved structure readily cleaves 3' overhangs in a time-dependent manner. It is similar to DEDD-type RNases and is an unusual ATP-binding protein that binds ATP...
Overlapping families in CDD: DEDDh, DnaQ_like_exo superfamily, dexA

Members of DUF5051 whose function may be known:

UPF0052 (PF01933.18): Uncharacterised protein family UPF0052 (293 a.a.), 48 papers
IPR002882: CofD/UPF0052. This entry contains LPPG:Fo 2-phospho-L-lactate transferase (CofD) and related sequences of unknown function belong to unidentified protein family UPF0052. CofD catalyses the fourth step in the biosynthesis of coenzyme F420, which is the transfer of the 2-phospholactate moiety from lactyl (2) diphospho-(5')guanosine (LPPG) to 7,8-didemethyl-8-hydroxy-5-deazariboflavin (FO) with the formation of the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) and GMP. F420...
Overlapping families in CDD: CofD, CofD_YvcK superfamily, CofD_like, CofD_related, F420_cofD, PRK13606, YvcK_like

Members of UPF0052 whose function may be known:

DUF202 (PF02656.15): Domain of unknown function (DUF202) (68 a.a.), 48 papers
IPR003807: DUF202. This entry describes a domain of unknown function found in bacterial inner membrane proteins and yeast vacuolar transporter chaperones.
Overlapping families in CDD: VTC1, YidH

Members of DUF202 whose function may be known:

DUF481 (PF04338.12): Protein of unknown function, DUF481 (212 a.a.), 48 papers
IPR007433: DUF481. This family includes several proteins of uncharacterised function.
Overlapping families in CDD: YdiY

Members of DUF481 whose function may be known:

DUF2370 (PF10176.9): Protein of unknown function (DUF2370) (226 a.a.), 47 papers
IPR019325: NEDD4/Bsd2. Proteins in this entry include the human NEDD4 family-interacting protein 1/2 (Ndfip1 and Ndfip2) and the yeast Bsd2 metal homeostatis proteins. Ndfip1 and Ndfip2 are endosomal membrane proteins that bind to and activate members of the Nedd4 family of E3 ubiquitin ligases. Ndfip1 plays a role in regulating metal transport in human neurons. Bsd2 is required for the targeting...
Overlapping families in CDD: Atrophin-1, Atrophin-1 superfamily

Members of DUF2370 whose function may be known:

UPF0029 (PF01205.19): Uncharacterized protein family UPF0029 (105 a.a.), 46 papers
IPR001498: Impact_N. The Impact protein is a translational regulator that ensures constant high levels of translation under amino acid starvation. It acts by interacting with Gcn1/Gcn1L1, thereby preventing activation of Gcn2 protein kinases (EIF2AK1 to 4) and subsequent down-regulation of protein synthesis. It is evolutionary conserved from eukaryotes to archaea. This entry represents the N-terminal domain of the Impact proteins.
Overlapping families in CDD: IMPACT_YIGZ, PRK11568, YIH1

Members of UPF0029 whose function may be known:

DUF839 (PF05787.13): Bacterial protein of unknown function (DUF839) (524 a.a.), 46 papers
IPR008557: DUF839. This family consists of bacterial proteins of unknown function.
Overlapping families in CDD: PhoX

Members of DUF839 whose function may be known:

DUF2470 (PF10615.9): Protein of unknown function (DUF2470) (77 a.a.), 46 papers
IPR019595: DUF2470. This entry represents an uncharacterised domain that can be found in a group of putative haem-iron utilisation proteins. It can also be found in C-terminal of the glutamyl-tRNA reductase-binding (GluTRBP) protein from Arabidopsis. GluTRBP is involved in the regulation of glutamyl-tRNA reductase (GluTR) which is important for the synthesis and distribution of 5-aminolevulinate, a precursor in heme and chlorophyll...

Members of DUF2470 whose function may be known:

DUF1126 (PF06565.12): DUF1126 PH-like domain (105 a.a.), 43 papers
IPR010554: DUF1126. The structure of this domain shows that it has a PH-like fold.
Overlapping families in CDD: DM10, EF-hand_7, EFh, EFh superfamily, EFh_PEF superfamily, FRQ1, PTZ00184

Members of DUF1126 whose function may be known:

DUF525 (PF04379.14): ApaG domain (87 a.a.), 42 papers
IPR007474: ApaG_domain. The apaG domain is a ~125 amino acids domain present in bacterial apaG proteins and in eukaryotic F-box proteins. The domain is named after the bacterial apaG protein, of which it forms the core. The domain also occurs in the C-terminal part of eukaryotic proteins with an N-terminal F-box domain. The Salmonella typhimurium apaG domain protein corD is involved...
Overlapping families in CDD: ApaG, apaG

Members of DUF525 whose function may be known:

DUF4097 (PF13349.6): Putative adhesin (252 a.a.), 42 papers
IPR025164: DUF4097. This has a putative all-beta structure with a twenty-residue repeat with a highly conserved repeating GD, gly-asp, motif. It may form part of a bacterial adhesin.
Overlapping families in CDD: DUF2807 superfamily, YvlB

Members of DUF4097 whose function may be known:

DUF262 (PF03235.14): Protein of unknown function DUF262 (221 a.a.), 41 papers
IPR004919: DUF262. This entry is found in prokaryotic proteins of unknown function.
Overlapping families in CDD: COG1479, COG3472, COG3472 superfamily

Members of DUF262 whose function may be known:

DUF563 (PF04577.14): Protein of unknown function (DUF563) (209 a.a.), 41 papers
IPR007657: Glycosyltransferase_61. Glycosyltransferase 61 family members are further processed into a mature form. Proteins in this family includes O-linked-mannose beta-1,4-N-acetylglucosaminyltransferase 2 (POMGnT2, also known as EOGTL) and EGF domain-specific O-linked N-acetylglucosamine transferase (EOGT). This entry also includes plant beta-(1,2)-xylosyltransferase.
Overlapping families in CDD: COG4421, FN3, FN3 superfamily, Prothymosin, Prothymosin superfamily, TIGR00089, UPF0004 superfamily

Members of DUF563 whose function may be known:

DUF883 (PF05957.13): Bacterial protein of unknown function (DUF883) (94 a.a.), 41 papers
IPR010279: YqjD/ElaB. This family consists of several bacterial proteins and includes the Escherichia coli genes for ElaB, YgaM and YqjD. YqjD is an inner membrane and ribosome binding protein expressed during the stationary growth phase. It is possible that YqjD inactivates ribosomes by localizing a part of the ribosome to the membrane during the stationary phase. Its expression is regulated by...
Overlapping families in CDD: ElaB, PRK10132, PRK10404

Members of DUF883 whose function may be known:

DUF1524 (PF07510.11): Protein of unknown function (DUF1524) (139 a.a.), 41 papers
IPR011089: DUF1524. This domain contains a conserved HXXP motif. The function of the domain is unknown.
Overlapping families in CDD: HNHc superfamily

Members of DUF1524 whose function may be known:

DUF3453 (PF11935.8): Domain of unknown function (DUF3453) (226 a.a.), 39 papers
IPR032460: Symplekin/Pta1_N. This domain can be found in the symplekin protein from animals and Pta1 protein from budding yeasts. This domain is typically between 239 to 261 amino acids in length. Symplekin is a scaffold protein that functions as a component of a multimolecular complex involved in histone mRNA 3'-end processing. Pta1 is involved in pre-tRNA processing. Pta1 is a subunit...

Members of DUF3453 whose function may be known:

DUF1356 (PF07092.12): Protein of unknown function (DUF1356) (232 a.a.), 38 papers
IPR009790: DUF1356_TMEM106. This family consists of several hypothetical mammalian proteins of around 250 residues in length. The function of this family is unknown.

Members of DUF1356 whose function may be known:

DUF2236 (PF09995.9): Uncharacterized protein conserved in bacteria (DUF2236) (227 a.a.), 38 papers
IPR018713: DUF2236. This domain, found in various hypothetical bacterial proteins, has no known function. It contains a highly conserved arginine and histidine that may be active site residues for an as yet unknown catalytic activity.

Members of DUF2236 whose function may be known:

DUF892 (PF05974.12): Domain of unknown function (DUF892) (159 a.a.), 37 papers
IPR010287: DUF892. This domain is found in several hypothetical bacterial proteins of unknown function.
Overlapping families in CDD: Ferritin_like superfamily, YciE, YciF

Members of DUF892 whose function may be known:

DUF3522 (PF12036.8): Protein of unknown function (DUF3522) (188 a.a.), 37 papers
IPR021910: NGX6/PGAP6/MYMK. Proteins in this family include PGAP6 (also known as TMEM8A), NGX6 (also known as TMEM8B) and myomaker (also known as TMEM8C). TMEM8C is embedded in the plasma membrane with seven membrane-spanning regions and a required intracellular C-terminal tail. It is essential for myoblast fusion and sufficient to promote fusion of fibroblasts with muscle cells. TMEM8A and TMEM8B has no...

Members of DUF3522 whose function may be known:

DUF308 (PF03729.13): Short repeat of unknown function (DUF308) (73 a.a.), 36 papers
IPR005325: DUF308_memb. This represents a group of short repeats that occurs in a limited number of membrane proteins. It may divide further in short repeats of around 7-10 residues of the pattern G-#-X(2)-#(2)-X (#=hydrophobic).
Overlapping families in CDD: HdeD, PRK10209

Members of DUF308 whose function may be known:

DUF3416 (PF11896.8): Domain of unknown function (DUF3416) (179 a.a.), 36 papers
IPR021828: GlgE_dom_N/S. This entry represents domain N and S of GlgE. GlgE is a homodimer and a member of the GH13_3 CAZy subfamily. Each subunit of GlgE is composed of five domains, four of which have been observed before in members of the GH13 alpha-amylase family of enzymes in the GH-H clan. Domain A is a (beta/alpha)8 barrel, typical of the...
Overlapping families in CDD: Alpha-amylase, Alpha-amylase superfamily, AmyA, AmyAc_GlgE_like, AmyAc_family superfamily, DEXDc superfamily, Malt_amylase_C, Malt_amylase_C superfamily, PRK04537, PRK10933, treS_nterm

Members of DUF3416 whose function may be known:

UPF0086 (PF01868.16): Domain of unknown function UPF0086 (84 a.a.), 35 papers
IPR002730: RNase_P/MRP_p29. RNase P is a ubiquitous ribonucleoprotein enzyme primarily responsible for cleaving the 5' leader sequence during maturation of tRNAs in all three domains of life. In bacteria, the catalytic RNA (typically ~120 kDa) is aided by a small protein cofactor (~14 kDa), while eukaryotic RNase P is a large RNP complex containing at least nine protein components. Eukaryotic nuclear...
Overlapping families in CDD: KOW superfamily, KOW_Spt5_5, POP4, PRK03879

Members of UPF0086 whose function may be known:

DUF386 (PF04074.12): YhcH/YjgK/YiaL (148 a.a.), 35 papers
IPR004375: YhcH/YjgK/YiaL. This family consists of bacterial proteins. YjgK (TabA) influences biofilm formation by toxin-antitoxin systems. Another member of this family, YhcH, is a possible sugar isomerase of sialic acid catabolism.
Overlapping families in CDD: EbgC, TIGR00022, ebgC

Members of DUF386 whose function may be known:

DUF3533 (PF12051.8): Protein of unknown function (DUF3533) (378 a.a.), 35 papers
IPR022703: DUF3533. This transmembrane domain is functionally uncharacterised. It is found in bacterial and eukaryotic proteins.

Members of DUF3533 whose function may be known:

DUF89 (PF01937.19): Protein of unknown function DUF89 (353 a.a.), 33 papers
IPR002791: DUF89. This domain is found in putative carboxyl methyltransferase Armt1, uncharacterized budding yeast protein YMR027W (PDB code: 3PT1), At2g17340 from Arabidopsis thaliana, and it is also found at the C-terminal portion of eukaryotic pantothenate kinases. Despite the characterization of Armt1 as a carboxyl methyltransferase, a second study suggests that these proteins are hydrolases whose function is to limit potentially harmful...

Members of DUF89 whose function may be known:

DUF1325 (PF07039.11): SGF29 tudor-like domain (132 a.a.), 33 papers
IPR010750: SGF29_tudor-like_dom. SAGA-associated factor 29 is involved in transcriptional regulation, probably through association with histone acetyltransferase (HAT) complexes like the TFTC-HAT or STAGA complexes. It also may be involved in MYC-mediated oncogenic transformation. It is a component of the ATAC complex, which is a complex with histone acetyltransferase activity on histones H3 and H4. This entry represents a domain found in...
Overlapping families in CDD: TUDOR, TUDOR superfamily, ValS, tRNA-synt_1g superfamily, valS

Members of DUF1325 whose function may be known:

DUF2154 (PF09922.9): Cell wall-active antibiotics response 4TMS YvqF (114 a.a.), 32 papers
IPR024425: DUF2154. This domain is found in various prokaryotic proteins, including cell wall-active antibiotic response proteins. This entry includes protein product of the yvqF gene, located immediately upstream of vraS. It is associated with glycopeptide resistance in Staphylococcus aureus.
Overlapping families in CDD: LiaF

Members of DUF2154 whose function may be known:

DUF4962 (PF16332.5): Domain of unknown function (DUF4962) (476 a.a.), 32 papers
IPR032518: HepII_N. This domain can be found in the N terminus of dermatan-sulfate epimerase from mammals, and heparin and heparin-sulfate lyase (also known as heparinase II) from bacteria.

Members of DUF4962 whose function may be known:

DUF2401 (PF10287.9): Putative TOS1-like glycosyl hydrolase (DUF2401) (229 a.a.), 31 papers
IPR018805: YJL171C/Tos1_C. This entry represents a domain found in a group of fungal cell wall proteins, including Tos1 and YJL171C from budding yeasts. They contain 5 highly conserved cysteines, two of which form a characteristic CGC sequence motif. Their function is not clear.
Overlapping families in CDD: DUF2403, DUF2403 superfamily, GH16_laminarinase_like, LamG superfamily

Members of DUF2401 whose function may be known:

DUF1712 (PF08217.11): Fungal domain of unknown function (DUF1712) (609 a.a.), 30 papers
IPR013176: Ccz1. This entry includes the fungal vacuolar fusion protein Ccz1 which forms a complex with Mon1. The CCZ1-MON1 complex acts where vesicles fuse with the vacuole and is required in several vacuolar delivery pathways including autophagy, pexophagy and endocytosis as well cytoplasm to vacuole transport. Ccz1 interacts with a GTPase during fusion.

Members of DUF1712 whose function may be known:

DUF1772 (PF08592.11): Domain of unknown function (DUF1772) (137 a.a.), 30 papers

Members of DUF1772 whose function may be known:

DUF2403 (PF10290.9): Glycine-rich protein domain (DUF2403) (63 a.a.), 30 papers
IPR018807: YJL171C/Tos1_N. This entry represents a domain found in a group of fungal cell wall proteins, including Tos1 and YJL171C from budding yeasts. The function of this glycine-rich domain is unknown.
Overlapping families in CDD: DUF2401, DUF2401 superfamily, GH16_laminarinase_like, LamG superfamily

Members of DUF2403 whose function may be known:

DUF155 (PF02582.14): Uncharacterised ACR, YagE family COG1723 (176 a.a.), 29 papers
IPR003734: DUF155. This entry represents a domain found in RMND1 from mammals, Sif2/Sif3 from fission yeasts and Rmd1/Rmd8/YDR282C (Mrx10) from budding yeasts. RMND1 and its yeast homologue, Mrx10, are mitochondrial proteins required for mitochondrial translation. Rmd1 and Rmd8 are cytoplasmic protein required for sporulation.
Overlapping families in CDD: Rmd1

Members of DUF155 whose function may be known:

DUF520 (PF04461.13): Protein of unknown function (DUF520) (161 a.a.), 29 papers
IPR007551: DUF520. This entry represents the UPF0234 family of uncharacterised proteins, which includes YajQ. In Pseudomonas syringae, YajQ functions as a host protein involved in the temporal control of bacteriophage Phi6 gene transcription. It has been shown to bind to the phage's major structural core protein P1, most likely activating transcription by acting indirectly on the RNA polymerase. YajQ may remain...
Overlapping families in CDD: PRK05412, YajQ, YajQ_like, YajQ_like superfamily

Members of DUF520 whose function may be known:

DUF1624 (PF07786.12): Protein of unknown function (DUF1624) (223 a.a.), 29 papers
IPR012429: DUF1624. These sequences are found in hypothetical proteins of unknown function expressed by bacterial and archaeal species. The region in question is approximately 230 residues long.
Overlapping families in CDD: COG4299, DUF418 superfamily, DUF5009

Members of DUF1624 whose function may be known:

DUF2013 (PF09431.10): Protein of unknown function (DUF2013) (138 a.a.), 29 papers
IPR018556: DUF2013. This domain is found at the C terminus of some proteins, including Ldb17, NCK-interacting protein and uncharacterised proteins. Ldb17 is involved in the regulation of endocytosis in yeast. NCK-interacting protein (also known as WASP-interacting SH3-domain protein) induces microspike formation in vivo. In vitro, stimulates N-WASP-induced ARP2/3 complex activation in the absence of CDC42. It may play an important role...

Members of DUF2013 whose function may be known:

DUF4378 (PF14309.6): Domain of unknown function (DUF4378) (165 a.a.), 29 papers
IPR025486: DUF4378. This domain is found in protein LONGIFOLIA 2. The function of this domain is not known.

Members of DUF4378 whose function may be known:

UPF0061 (PF02696.14): Uncharacterized ACR, YdiU/UPF0061 family (468 a.a.), 27 papers
IPR003846: UPF0061. The proteins in this entry are functionally uncharacterised.
Overlapping families in CDD: PRK00029, YdiU

Members of UPF0061 whose function may be known:

DUF295 (PF03478.18): Protein of unknown function (DUF295) (55 a.a.), 27 papers
IPR005174: DUF295. This domain is found in plant proteins, many of which also contain an F-box domain.
Overlapping families in CDD: F-box superfamily, FBOX, PLN03215

Members of DUF295 whose function may be known:

DUF444 (PF04285.12): Protein of unknown function (DUF444) (421 a.a.), 27 papers
IPR006698: UPF0229. This family consists of bacterial proteins of unknown function.
Overlapping families in CDD: PRK05325, YeaH, spore_yhbH, vWFA superfamily

Members of DUF444 whose function may be known:

DUF588 (PF04535.12): Domain of unknown function (DUF588) (150 a.a.), 27 papers
IPR006702: CASP_dom. This domain is found mainly in plant proteins known as Casparian strip membrane proteins (CASPs). CASPs are four-membrane-span proteins that mediate the deposition of Casparian strips in the endodermis by recruiting the lignin polymerization machinery. Interestingly, the CASP first extracellular loop was found conserved in euphyllophytes but absent in plants lacking Casparian strips.
Overlapping families in CDD: A_tha_TIGR01569, MARVEL superfamily

Members of DUF588 whose function may be known:

DUF1127 (PF06568.11): Domain of unknown function (DUF1127) (37 a.a.), 27 papers
IPR009506: DUF1127. This family is found in several hypothetical bacterial proteins. In some cases it represents it represents the C-terminal region whereas in others it represents the whole sequence.
Overlapping families in CDD: YjiS

Members of DUF1127 whose function may be known:

DUF1771 (PF08590.10): Domain of unknown function (DUF1771) (64 a.a.), 27 papers
IPR013899: DUF1771. This domain is almost always found adjacent to .
Overlapping families in CDD: CUE_N4BP2, EGD2, NAC superfamily, SMR, Smr superfamily, UBA_like_SF superfamily

Members of DUF1771 whose function may be known:

DUF3808 (PF10300.9): Protein of unknown function (DUF3808) (477 a.a.), 27 papers
IPR019412: Iml2/TPR_39. This entry represents a family of proteins conserved from fungi to humans, including fungal Iml2 protein, animal tetratricopeptide repeat protein 39A/B/C (TT39A/B/C) and some characterised proteins. Members of this family carry a tetratricopeptide repeat at their C terminus. In Saccharomyces cerevisiae, Iml2 and its paralogue-YKR018C are included in this entry. Iml2 localises to the cytoplasm and nucleus, and its...

Members of DUF3808 whose function may be known:

DUF4101 (PF13355.6): Protein of unknown function (DUF4101) (117 a.a.), 27 papers
IPR025344: DUF4101. This presumed domain is functionally uncharacterised.

Members of DUF4101 whose function may be known:

DUF535 (PF04393.13): Protein of unknown function (DUF535) (281 a.a.), 26 papers
IPR007488: DUF535. Family member Shigella flexneri VirK is a virulence protein required for the expression, or correct membrane localisation of IcsA (VirG) on the bacterial cell surface. This family also includes Pasteurella haemolytica lapB, which is thought to be membrane-associated.
Overlapping families in CDD: VirK

Members of DUF535 whose function may be known:

DUF953 (PF06110.11): Eukaryotic protein of unknown function (DUF953) (119 a.a.), 26 papers
IPR010357: DUF953_thioredox. This family consists of several hypothetical eukaryotic proteins of unknown function that are thioredoxin-like.
Overlapping families in CDD: TRP14_like, Thioredoxin_like superfamily, TrxA

Members of DUF953 whose function may be known:

DUF1713 (PF08213.11): Mitochondrial domain of unknown function (DUF1713) (33 a.a.), 26 papers
IPR013177: DUF1713. This domain is found at the C-terminal end of mitochondrial mRNA-processing protein COX24, which is involved in the splicing of the COX1 mRNA. It is also found in aurora-A kinase interacting protein (AIP).

Members of DUF1713 whose function may be known:

DUF3697 (PF12478.8): Ubiquitin-associated protein 2 (35 a.a.), 26 papers
IPR022166: DUF3697_Uba2. This domain family is found in eukaryotes, and is approximately 30 amino acids in length. The family is found in association with . There are two conserved sequence motifs: AVEMPG and QFG.
Overlapping families in CDD: PRK12678, Rho superfamily, UBA, UBA_4, UBA_UBP2_like, UBA_like_SF superfamily

Members of DUF3697 whose function may be known:

Rv2175c_C (PF18367.1): Rv2175c C-terminal domain of unknown function (56 a.a.), 26 papers
Overlapping families in CDD: PBP2_TAXI_TRAP_like_2, Periplasmic_Binding_Protein_Type_2 superfamily

Members of Rv2175c_C whose function may be known:

DUF445 (PF04286.12): Protein of unknown function (DUF445) (367 a.a.), 25 papers
IPR007383: DUF445. This entry represents a large family of proteins with unknown function. They are predicted to be transmembrane (TM) proteins with 2 or 3 TM domains.
Overlapping families in CDD: YheB, YheB superfamily, YjiN

Members of DUF445 whose function may be known:

DUF485 (PF04341.12): Protein of unknown function, DUF485 (89 a.a.), 25 papers
IPR007436: DUF485. This family includes several putative integral membrane proteins.
Overlapping families in CDD: YjcH

Members of DUF485 whose function may be known:

DUF573 (PF04504.14): Protein of unknown function, DUF573 (95 a.a.), 25 papers
IPR007592: GEBP. This family of plant transcription factors includes GLABROUS1 enhancer-binding protein (GeBP) and GeBP-like proteins, and storekeeper and storekeeper-like (STKL) transcription factors. GeBP and GeBP-like proteins play a redundant role in cytokinin hormone pathway regulation. Storekeeper was identified as a B-box motif binding factor that regulates expression of patatin, a storage protein in potato. Storekeeper-like transcription factors STKL1 and STKL2...
Overlapping families in CDD: MDN1, MDN1 superfamily

Members of DUF573 whose function may be known:

DUF903 (PF06004.12): Bacterial protein of unknown function (DUF903) (49 a.a.), 25 papers
IPR010305: DUF903. This family consists of several small bacterial proteins several of which are classified as putative lipoproteins. The function of this family is unknown.
Overlapping families in CDD: Rotamase_2 superfamily, prsA

Members of DUF903 whose function may be known:

DUF1120 (PF06551.12): Protein of unknown function (DUF1120) (116 a.a.), 25 papers
IPR010546: DUF1120. This family consists of several bacterial proteins, at least one of which is involved in enzyme induction following nitrogen deprivation. The exact function of this family is unknown
Overlapping families in CDD: PRK15302, PRK15303

Members of DUF1120 whose function may be known:

DUF2046 (PF09755.9): Uncharacterized conserved protein H4 (DUF2046) (304 a.a.), 25 papers
IPR019152: DUF2046. This is the conserved N-terminal 350 residues of a family of proteins of unknown function possibly containing a coiled-coil domain.
Overlapping families in CDD: PRK03918, SMC_N superfamily, SMC_prok_A, Smc, TOP4c, TOP4c superfamily

Members of DUF2046 whose function may be known:

DUF4154 (PF13689.6): YfiR/HmsC-like (143 a.a.), 25 papers
IPR025293: YfiR/HmsC-like. YfiR has been shown to regulate YfiN, a diguanylate cyclase and a bifunctional protein that produces c-di-GMP in response to reductive stress and then dynamically relocates to the division site to arrest cell division in response to envelope stress in Escherichia coli. YfiR may serve as a periplasmic redox sensor that regulates YfiN activity in response to reducing conditions....

Members of DUF4154 whose function may be known:

DUF179 (PF02622.15): Uncharacterized ACR, COG1678 (160 a.a.), 24 papers
IPR003774: UPF0301. This entry describes proteins of unknown function. Proteins in this family include AlgH from Pseudomonas aeruginosa. AlgH is involved in the transcriptional regulation of alginate biosynthesis. However, there is no evidence for such function in proteins belonging to this family.
Overlapping families in CDD: AlgH, PRK00228

Members of DUF179 whose function may be known:

UPF0203 (PF05254.12): Uncharacterised protein family (UPF0203) (69 a.a.), 24 papers
IPR007918: MDM35_apoptosis. This is a family of small highly conserved proteins. In Saccharomyces cerevisiae (Baker's yeast) the gene YKL053C-A (MDM35) is one of the genes essential for maintenance of normal mitochondrial distribution and morphology (MDM); wherease in Homo sapiens (Human), p53CSV, is a direct transcriptional target for p53 and appears to be a cell-survival mediator in response to genotoxic stress including...
Overlapping families in CDD: PLN03079

Members of UPF0203 whose function may be known:

UPF0227 (PF05728.12): Uncharacterised protein family (UPF0227) (187 a.a.), 24 papers
IPR008886: UPF0227/Esterase_YqiA. Despite being classed as uncharacterised proteins, the members of this family are almost certainly enzymes in that they contain a domain distantly related to . One of the members of this family YqiA has been shown to be a esterase. Other members, which include the Escherichia coli (strain K12) YcfP protein are uncharacterised.
Overlapping families in CDD: Abhydrolase superfamily, PRK11071, ycfP

Members of UPF0227 whose function may be known:

DUF3421 (PF11901.8): Protein of unknown function (DUF3421) (115 a.a.), 24 papers
IPR024518: DUF3421. This domain of unknown function is found in the fish toxin Natterin and in uncharacterised proteins.
Overlapping families in CDD: DM9

Members of DUF3421 whose function may be known:

UPF0014 (PF03649.13): Uncharacterised protein family (UPF0014) (242 a.a.), 23 papers
IPR005226: UPF0014_fam. Characterised proteins in this family include probable iron export permease protein FetB, which is part of the ABC transporter complex FetAB, probably involved in iron export, and aluminum sensitive 3 protein, also part of an ABC transporter required for aluminum (Al) resistance. This family also includes integral membrane proteins currently uncharacterised.
Overlapping families in CDD: FetB, TIGR00245

Members of UPF0014 whose function may be known:

DUF692 (PF05114.13): Protein of unknown function (DUF692) (263 a.a.), 23 papers
IPR007801: UPF0276. The proteins in this entry are functionally uncharacterised.
Overlapping families in CDD: AP2Ec superfamily, COG3220, PRK05409

Members of DUF692 whose function may be known:

DUF773 (PF05600.12): CDK5 regulatory subunit-associated protein 3 (508 a.a.), 23 papers
IPR008491: CDK5RAP3. CDK5RAP3 (also known as C53 or LZAP) serves as a probable tumour suppressor initially identified as a CDK5R1 interactor controlling cell proliferation. It negatively regulates NF-kappa-B-mediated gene transcription through the control of RELA phosphorylation. It also regulates mitotic G2/M transition checkpoint and mitotic G2 DNA damage checkpoint. It has been shown to bind Wip1 and stimulates its phosphatase activity.
Overlapping families in CDD: Toprim_N superfamily, dnaG

Members of DUF773 whose function may be known:

DUF805 (PF05656.14): Protein of unknown function (DUF805) (105 a.a.), 23 papers
IPR008523: DUF805. This family consists of several bacterial proteins of unknown function.
Overlapping families in CDD: yhaH

Members of DUF805 whose function may be known:

DUF410 (PF04190.13): Protein of unknown function (DUF410) (255 a.a.), 22 papers
IPR007317: UPF0363. This is a family of conserved eukaryotic proteins with undetermined function.

Members of DUF410 whose function may be known:

DUF572 (PF04502.13): Family of unknown function (DUF572) (332 a.a.), 22 papers
IPR007590: CWC16. This entry includes CCDC130 and CCDC94 from humans, Cwf16 from fission yeasts and Yju2 from budding yeasts. Cwf16 is involved in mRNA splicing where it associates with cdc5 and the other cwf proteins as part of the spliceosome. Yju2 is a splicing factor that is associated with the Prp19-associated complex and acts after Prp2 in promoting the first catalytic...
Overlapping families in CDD: COG5134

Members of DUF572 whose function may be known:

DUF727 (PF05303.12): Protein of unknown function (DUF727) (105 a.a.), 22 papers
IPR007967: GSKIP_dom. This domain is found in GSK3-beta interaction protein (GSKIP), which binds to GSK3beta. It is also found as a short domain towards the N terminus in clustered mitochondria protein, also known as clueless in Drosophila, which is involved in proper cytoplasmic distribution of mitochondria.

Members of DUF727 whose function may be known:

DUF3692 (PF12469.8): CRISPR-associated protein (111 a.a.), 22 papers
IPR024615: CRISPR-assoc_Cmr2_N. This domain family is typically between 101 and 138 amino acids in length and is found in subunit Crm2 of the CRISPR RNA-Cas protein complex (Cmr complex).
Overlapping families in CDD: Cas10, Cas10 superfamily, Cas10_III, Cas10_III superfamily, GlgA superfamily, PLN02316, cas_TM1794_Cmr2

Members of DUF3692 whose function may be known:

DUF543 (PF04418.12): Domain of unknown function (DUF543) (74 a.a.), 21 papers
IPR007512: Mic10. Mic10 (also known as MINOS1) is a component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.

Members of DUF543 whose function may be known:

DUF775 (PF05603.12): Protein of unknown function (DUF775) (199 a.a.), 21 papers
IPR008493: DUF775. The function of the DUF775 domain is not clear.

Members of DUF775 whose function may be known:

DUF1375 (PF07119.12): Protein of unknown function (DUF1375) (53 a.a.), 21 papers
IPR010780: DUF1375. This family consists of several hypothetical, putative lipoproteins of around 80 residues in length. Members of this family seem to be specific to the class Gammaproteobacteria. The function of this family is unknown.
Overlapping families in CDD: PRK10175, PRK11616, YceK

Members of DUF1375 whose function may be known:

DUF2406 (PF10295.9): Uncharacterised protein (DUF2406) (64 a.a.), 21 papers
IPR018809: DUF2406. This entry represents a family of small proteins conserved in fungi. The function is not known.

Members of DUF2406 whose function may be known:

NTPase_I-T (PF01931.18): Protein of unknown function DUF84 (163 a.a.), 20 papers
IPR026533: NTPase/PRRC1. This entry represents a domain found in non-canonical purine NTP phosphatases and in PRRC1 (proline-rich and coiled-coil-containing protein 1). These phosphatases hydrolyse non-canonical purine nucleotides such as XTP and ITP to their respective diphosphates derivatives. PRRC1 is a Golgi-associated protein of unknown function.
Overlapping families in CDD: PRK03941, PRK05074, TIGR00258, YjjX

Members of NTPase_I-T whose function may be known:

DUF1307 (PF06998.11): Protein of unknown function (DUF1307) (123 a.a.), 20 papers
IPR009736: DUF1307. This family consists of several hypothetical bacterial proteins of around 150 residues in length. Some family members are described as putative lipoproteins but the function of the family is unknown.
Overlapping families in CDD: YehR

Members of DUF1307 whose function may be known:

DUF1328 (PF07043.13): Protein of unknown function (DUF1328) (39 a.a.), 20 papers
IPR009760: DUF1328. This entry represents several hypothetical bacterial proteins of around 50 residues in length. The function of this family is unknown but is thought to be a membrane protein.
Overlapping families in CDD: PRK13682, YtjA

Members of DUF1328 whose function may be known:

DUF1751 (PF08551.10): Eukaryotic integral membrane protein (DUF1751) (99 a.a.), 20 papers
IPR013861: DUF1751_Mem_euk. This entry represents a group of eukaryotic transmembrane proteins, including TMEM115 from animals, Pdh1 from fission yeasts and Rbl19 from Arabisopsis. Human TMEM115 is an integral membrane protein of the Golgi complex involved in retrograde transport. Budding yeast TMEM115 homologue, YOL107W, has been shown to localise COP II vesicles.
Overlapping families in CDD: Rhomboid superfamily

Members of DUF1751 whose function may be known:

DUF1971 (PF09313.11): Domain of unknown function (DUF1971) (80 a.a.), 20 papers
IPR015392: DUF1971. This uncharacterised domain is predominantly found in bacterial Tellurite resistance proteins.
Overlapping families in CDD: PRK12335, PRK12335 superfamily, TehB, cupin_like superfamily

Members of DUF1971 whose function may be known:

DUF3338 (PF11819.8): Domain of unknown function (DUF3338) (136 a.a.), 20 papers
IPR021774: DUF3338. This domain is functionally uncharacterised. It is found in eukaryotes. This presumed domain is about 130 amino acids in length.

Members of DUF3338 whose function may be known:

UPF0121 (PF03661.13): Uncharacterised protein family (UPF0121) (241 a.a.), 19 papers
IPR005344: TMEM33/Pom33. This entry represents the TMEM33/Pom33 family. Budding yeast Pom33 is a transmembrane nucleoporin that contributes to proper distribution and/or efficient assembly of nuclear pores. Proteins in this entry also include Tts1 from fission yeasts, Kr-h2 (krueppel homologue 2) from flies and TMEM33 from vertebrates. Tts1 is required for the correct positioning of the cellular division plane by delimiting the...

Members of UPF0121 whose function may be known:

DUF702 (PF05142.12): Domain of unknown function (DUF702) (150 a.a.), 19 papers
Overlapping families in CDD: LRP1_Cterm, LRP1_Cterm superfamily, put_zinc_LRP1

Members of DUF702 whose function may be known:

DUF747 (PF05346.11): Eukaryotic membrane protein family (319 a.a.), 19 papers
IPR008010: Tatp1. This family of membrane proteins is conserved in eukaryotes. It includes Tapt1 (transmembrane anterior posterior transformation 1) and homologues. Analysis of mouse Tapt1 has shown it to be involved in patterning of the vertebrate axial skeleton. Its cellular function is not known, but defective Tapt1 disrupts Golgi morphology and trafficking, and normal primary cilium formation. The homologues in yeast,...

Members of DUF747 whose function may be known:

DUF846 (PF05832.12): Eukaryotic protein of unknown function (DUF846) (139 a.a.), 19 papers
IPR008564: TVP23-like. Tvp23 is a Golgi membrane protein involved in vesicular trafficking.

Members of DUF846 whose function may be known:

UPF0047 (PF01894.17): Uncharacterised protein family UPF0047 (115 a.a.), 18 papers
IPR001602: UPF0047. This family contains small uncharacterised proteins of 14 to 16 kDa mainly from bacteria although the signatures also occur in a hypothetical protein from archaea and from yeast.
Overlapping families in CDD: TIGR00149_YjbQ, YjbQ

Members of UPF0047 whose function may be known:

DUF568 (PF04526.13): Protein of unknown function (DUF568) (101 a.a.), 18 papers
IPR005018: DOMON_domain. The DOMON domain is an 110-125 residue long domain which has been identified in the physiologically important enzyme dopamine beta-monooxygenase and in several other secreted and transmembrane proteins from both plants and animals. It has been named after DOpamine beta-MOnooxygenase N-terminal domain. The DOMON domain can be found in one to four copies and in association with other domains,...
Overlapping families in CDD: B561, Cyt_b561_FRRS1_like, Cytochrome_b_N superfamily, DOMON_CIL1_like, DOMON_like superfamily, DoH

Members of DUF568 whose function may be known:

DUF1338 (PF07063.13): Domain of unknown function (DUF1338) (324 a.a.), 18 papers
IPR009770: DUF1338. This domain is found in a variety of bacterial and fungal hypothetical proteins of unknown function. The structure of this domain has been solved by structural genomics. The structure implies a zinc-binding function, so it is a putative metal hydrolase (information derived from TOPSAN for PDB:3iuz).
Overlapping families in CDD: VOC superfamily, VOC_YdcJ_like, YdcJ

Members of DUF1338 whose function may be known:

DUF1906 (PF08924.11): Domain of unknown function (DUF1906) (198 a.a.), 18 papers
IPR015020: DUF1906. This entry represents a family of uncharacterised hypothetical bacterial proteins, including the putative peptidoglycan hydrolase Rv2525c from Mycobacterium tuberculosis.
Overlapping families in CDD: GH25_BacA-like, GH25_muramidase superfamily

Members of DUF1906 whose function may be known:

DUF2012 (PF09430.10): Protein of unknown function (DUF2012) (123 a.a.), 18 papers
IPR019008: DUF2012. This domain is found in different proteins, including uncharacterised protein family UPF0480 and nodal modulators. A nodal modulator has been identified as part of a protein complex that participates in the nodal signaling pathway during vertebrate development. This domain is also found in ER membrane protein complex subunit 7 (EMC7), which is a component of the endoplasmic reticulum membrane...
Overlapping families in CDD: Peptidase_M14NE-CP-C_like superfamily

Members of DUF2012 whose function may be known:

DUF2057 (PF09829.9): Uncharacterized protein conserved in bacteria (DUF2057) (193 a.a.), 18 papers
IPR018635: UPF0319. The proteins in this entry are functionally uncharacterised.
Overlapping families in CDD: PRK03641, YccT

Members of DUF2057 whose function may be known:

DUF3281 (PF11685.8): Protein of unknown function (DUF3281) (267 a.a.), 18 papers
IPR021699: DUF3281. This family of bacterial proteins has no known function. This entry includes bacterial lipoprotein FTN_103 from Francisella novicida.
Overlapping families in CDD: DUF1522 superfamily, PRK12688

Members of DUF3281 whose function may be known:

DUF1151 (PF06625.11): Protein of unknown function (DUF1151) (114 a.a.), 17 papers
IPR009533: FAM107. This entry includes FAM107A/B. FAM107A (also known as DRR1) is an actin-associated protein that plays important roles in tumor cell growth, neuron survival and spine formation. The function of FAM107B is not clear.
Overlapping families in CDD: EnvC, PRK05771, Peptidase_M23 superfamily, V_ATPase_I superfamily

Members of DUF1151 whose function may be known:

DUF2063 (PF09836.9): Putative DNA-binding domain (85 a.a.), 17 papers
IPR018640: DUF2063. This entry represents the N-terminal part of a Neisseria protein( ), PDB:3dee. It runs from residues 31-117 as a helical bundle with 4 main helices. From genomic context and the fold of the C-terminal part, it is suggested that this protein is involved in transcriptional regulation.
Overlapping families in CDD: COG3219

Members of DUF2063 whose function may be known:

UPF0060 (PF02694.15): Uncharacterised BCR, YnfA/UPF0060 family (107 a.a.), 16 papers
IPR003844: UPF0060. This entry describes a family of integral membrane proteins of unknown function.
Overlapping families in CDD: PRK02237, YnfA

Members of UPF0060 whose function may be known:

UPF0093 (PF03653.13): Uncharacterised protein family (UPF0093) (146 a.a.), 16 papers
IPR005265: HemJ-like. This entry includes HemJ from Synechocystis sp. (strain PCC 6803 / Kazusa). It is essential for protoporphyrinogen IX oxidase activity and is functionally coupled with coproporphyrinogen III oxidase.
Overlapping families in CDD: COG1981, CopD superfamily, TIGR00701

Members of UPF0093 whose function may be known:

DUF778 (PF05608.12): Protein of unknown function (DUF778) (189 a.a.), 16 papers
IPR008496: DUF778. This family consists of several eukaryotic proteins of unknown function.

Members of DUF778 whose function may be known:

DUF810 (PF05664.11): Plant family of unknown function (DUF810) (686 a.a.), 16 papers

Members of DUF810 whose function may be known:

DUF1279 (PF06916.13): Protein of unknown function (DUF1279) (92 a.a.), 16 papers
IPR009688: DUF1279. This entry represents the C terminus (approx. 120 residues) of a number of eukaryotic proteins of unknown function.
Overlapping families in CDD: Kri1, Kri1 superfamily, YtxH, YtxH superfamily

Members of DUF1279 whose function may be known:

DUF1302 (PF06980.11): Protein of unknown function (DUF1302) (570 a.a.), 16 papers
IPR010727: DUF1302. This family contains a number of hypothetical bacterial proteins of unknown function that are approximately 600 residues long. Most family members seem to be from Pseudomonas.

Members of DUF1302 whose function may be known:

DUF1440 (PF07274.12): Protein of unknown function (DUF1440) (135 a.a.), 16 papers
IPR009898: DUF1440. This family contains a number of bacterial proteins of unknown function approximately 180 residues long. These are possibly integral membrane proteins.
Overlapping families in CDD: YagU

Members of DUF1440 whose function may be known:

DUF1619 (PF07773.11): Protein of unknown function (DUF1619) (317 a.a.), 16 papers
IPR011677: DUF1619. This is a group of sequences derived from hypothetical eukaryotic proteins. The region in question is approximately 330 residues long and has a cysteine rich N terminus.

Members of DUF1619 whose function may be known:

DUF1640 (PF07798.11): Protein of unknown function (DUF1640) (175 a.a.), 16 papers
IPR024461: DUF1640. This entry includes coiled-coil domain-containing proteins 90 (CCDC90) and related proteins. CCDC90A was reported to be a regulator of the mitochondrial calcium uniporter (MCU) and hence was renamed MCUR1. However, studies in mammals and in yeast homologue fmp32 have shown that it is a cytochrome c oxidase assembly factor and does not directly regulate MCU. The role of CCDC90B...
Overlapping families in CDD: Mplasa_alph_rch, SMC_N superfamily

Members of DUF1640 whose function may be known:

DUF1656 (PF07869.12): Protein of unknown function (DUF1656) (56 a.a.), 16 papers
IPR012451: DUF1656. The proteins in this entry have no known function and belong to the AaeX family.
Overlapping families in CDD: PRK11594

Members of DUF1656 whose function may be known:

DUF1674 (PF07896.12): Protein of unknown function (DUF1674) (50 a.a.), 16 papers
IPR012875: DUF1674. The members of this family are sequences derived from hypothetical eukaryotic and bacterial proteins. The region in question is approximately 60 residues long.
Overlapping families in CDD: COG5508, YuxH, YuxH superfamily

Members of DUF1674 whose function may be known:

UPF0300 (PF08594.10): Uncharacterised protein family (UPF0300) (212 a.a.), 16 papers
IPR013903: Meiotic_expression. This family of proteins appear to be specific to Schizosaccharomyces (Fission yeast). Their exact function is unknown, but they are up-regulated in meiosis and some of them have been shown to be required for critical meiotic events.

Members of UPF0300 whose function may be known:

DUF1949 (PF09186.11): Domain of unknown function (DUF1949) (56 a.a.), 16 papers
IPR015269: UPF0029_Impact_C. Members of this entry are a set of functionally uncharacterised hypothetical bacterial proteins. They adopt a ferredoxin-like fold, with a beta-alpha-beta-beta-alpha-beta arrangement. This entry contains the protein Impact, which is a translational regulator that ensures constant high levels of translation under amino acid starvation. It acts by interacting with Gcn1/Gcn1L1, thereby preventing activation of Gcn2 protein kinases (EIF2AK1 to...
Overlapping families in CDD: IMPACT_YIGZ, PRK11568, UPF0029, UPF0029 superfamily, YIH1

Members of DUF1949 whose function may be known:

DUF2183 (PF09949.9): Uncharacterized conserved protein (DUF2183) (99 a.a.), 16 papers
IPR019236: DUF2183. This domain, found in various bacterial and fungal proteins, has no known function.
Overlapping families in CDD: App1

Members of DUF2183 whose function may be known:

UPF0564 (PF10595.9): Uncharacterised protein family UPF0564 (364 a.a.), 16 papers
IPR019579: UPF0564. This entry represents proteins with no known function.
Overlapping families in CDD: Neuromodulin_N superfamily, PTZ00121

Members of UPF0564 whose function may be known:

DUF2974 (PF11187.8): Protein of unknown function (DUF2974) (224 a.a.), 16 papers
IPR024499: DUF2974. This family of proteins has no known function.

Members of DUF2974 whose function may be known:

DUF3494 (PF11999.8): Protein of unknown function (DUF3494) (209 a.a.), 16 papers
IPR021884: Ice-bd_prot-like. This entry represents a group of proteins found in bacteria, archaea and eukaryotes, including ice-binding protein from fungi. In Antarctic bacterium Flavobacterium frigoris PS1, FfIBP is an ice-binding proteins (IBPs) that inhibit ice growth through direct interaction with ice crystals to permit the survival of polar organisms in extremely cold environments. In arctic yeast Leucosporidium sp, LeIBP, an ice-binding...

Members of DUF3494 whose function may be known:

DUF3589 (PF12141.8): Beta-mannosyltransferases (491 a.a.), 16 papers
IPR021988: BMT1. This entry represents a group of fungal beta-mannosyltransferase that is involved in cell wall biosynthesis.

Members of DUF3589 whose function may be known:

DUF72 (PF01904.18): Protein of unknown function DUF72 (218 a.a.), 15 papers
IPR002763: DUF72. The function of this family is unknown. Aquifex aeolicus has two copies of this protein. A probable aspartyl-tRNA synthetase from Escherichia coli belongs to this group.
Overlapping families in CDD: ICL_KPHMT superfamily, PRK10302, YecE, pyrF_sub2

Members of DUF72 whose function may be known:

DUF98 (PF01947.16): p-hydroxybenzoic acid synthase (149 a.a.), 15 papers
IPR002800: Rv2949c-like. This entry includes chorismate pyruvate-lyase Rv2949c from Mycobacterium tuberculosis. It removes the pyruvyl group from chorismate to provide 4-hydroxybenzoate (4HB).
Overlapping families in CDD: Chor_lyase superfamily, UbiC

Members of DUF98 whose function may be known:

UPF0126 (PF03458.13): UPF0126 domain (78 a.a.), 15 papers
IPR005115: UPF0126. This domain is duplicated in bacterial membrane proteins of unknown function and each domain contains three transmembrane helices. The conserved glycines are suggestive of an ion channel.
Overlapping families in CDD: PRK10578, YadS

Members of UPF0126 whose function may be known:

DUF333 (PF03891.15): Domain of unknown function (DUF333) (48 a.a.), 15 papers
IPR005590: DUF333. This family consists of functionally uncharacterised bacterial proteins.
Overlapping families in CDD: FlgH superfamily, Hlx, PRK10672, RlpA superfamily, flgH

Members of DUF333 whose function may be known:

DUF493 (PF04359.14): Protein of unknown function (DUF493) (84 a.a.), 15 papers
IPR007454: UPF0250. This family includes several proteins of uncharacterised function.
Overlapping families in CDD: PRK04998, YbeD

Members of DUF493 whose function may be known:

DUF559 (PF04480.12): Protein of unknown function (DUF559) (109 a.a.), 15 papers
IPR007569: DUF559. This entry represents a protein of unknown function, but is thought to be a DNA mismatch repair endonuclease.
Overlapping families in CDD: AsnC_trans_reg superfamily, Endonuclease_DUF559, HTH_ASNC, Restriction_endonuclease_like superfamily, Vsr

Members of DUF559 whose function may be known:

DUF697 (PF05128.12): Domain of unknown function (DUF697) (162 a.a.), 15 papers
IPR021147: DUF697. Proteins in this entry have no known function.
Overlapping families in CDD: PRK05415, YcjF, YcjF superfamily, hyp_HI0043

Members of DUF697 whose function may be known:

DUF737 (PF05300.11): Protein of unknown function (DUF737) (201 a.a.), 15 papers
IPR007964: MIC19/MIC25. MIC19 (also known as ChChd3) and MIC25 (also known as ChChd6) are components of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. MIC19 plays an important role in the maintenance of the MICOS...
Overlapping families in CDD: CHCH, CHCH superfamily, Neuromodulin_N superfamily, PTZ00121, SMC_N superfamily, SMC_prok_A

Members of DUF737 whose function may be known:

DUF935 (PF06074.12): Protein of unknown function (DUF935) (520 a.a.), 15 papers
IPR009279: DUF935. This family consists of several bacterial proteins of unknown function as well as the Bacteriophage Mu Gp29 protein .
Overlapping families in CDD: gp29

Members of DUF935 whose function may be known:

DUF1329 (PF07044.11): Protein of unknown function (DUF1329) (364 a.a.), 15 papers
IPR010752: DUF1329. This family consists of several hypothetical bacterial proteins of around 475 residues in length. The majority of family members are from Pseudomonas species but the family also contains sequences from Shewanella oneidensis and Thauera aromatica .
Overlapping families in CDD: LolA superfamily, LolA_fold-like superfamily, LolA_like

Members of DUF1329 whose function may be known:

DUF1398 (PF07166.11): Protein of unknown function (DUF1398) (119 a.a.), 15 papers
IPR009833: DUF1398. This family consists of several hypothetical bacterial proteins of around 130 residues in length. The function of this family is unknown.
Overlapping families in CDD: YbcV

Members of DUF1398 whose function may be known:

DUF1445 (PF07286.12): Protein of unknown function (DUF1445) (143 a.a.), 15 papers
IPR009906: D-Glu_cyclase. This family includes mitochondrial D-glutamate cyclase (EC:4.2.1.48), which converts D-glutamate to 5-oxo-D-proline. The family also includes numerous uncharacterized proteins from bacteria.
Overlapping families in CDD: DUF4392, DUF4392 superfamily, PRK05463, YcsI

Members of DUF1445 whose function may be known:

DUF2418 (PF10332.9): Protein of unknown function (DUF2418) (96 a.a.), 15 papers
IPR018819: DUF2418. This entry represents the conserved 100 residue central region from a family of proteins found in fungi. It carries a characteristic EYD sequence motif. The function is not known.

Members of DUF2418 whose function may be known:

DUF4149 (PF13664.6): Domain of unknown function (DUF4149) (102 a.a.), 15 papers
IPR025423: DUF4149. This presumed domain is functionally uncharacterised.

Members of DUF4149 whose function may be known:

DUF4188 (PF13826.6): Domain of unknown function (DUF4188) (117 a.a.), 15 papers
IPR025444: Monooxy_af470. This family consists of proteins from bacteria and fungi. It includes monooxygenase af470 from Aspergillus fumigatus, which is part of the fma gene cluster that mediates the biosynthesis of fumagillin, a meroterpenoid with numerous biological activities. It has been suggested that af470 mediates the oxidative cleavage of the terminal alkene of the dodecapentaenoate side chain into the carboxylic acid...

Members of DUF4188 whose function may be known:

DUF4200 (PF13863.6): Domain of unknown function (DUF4200) (119 a.a.), 15 papers
IPR025252: DUF4200. This entry represents a coiled-coil domain. Its function is unknown.
Overlapping families in CDD: Neuromodulin_N superfamily, PTZ00121, SMC_N superfamily, SMC_prok_A, SMC_prok_B, Smc, iSH2_PI3K_IA_R superfamily

Members of DUF4200 whose function may be known:

DUF406 (PF04175.12): Protein of unknown function (DUF406) (92 a.a.), 14 papers
IPR005272: CHP00743. These small proteins are approximately 100 amino acids in length and appear to be found only in gamma proteobacteria. The function of this protein family is unknown.
Overlapping families in CDD: PRK09981, TIGR00743, YfcZ

Members of DUF406 whose function may be known:

DUF454 (PF04304.13): Protein of unknown function (DUF454) (115 a.a.), 14 papers
IPR007401: DUF454. This is a predicted membrane protein.
Overlapping families in CDD: PRK10527, YbaN

Members of DUF454 whose function may be known:

DUF498 (PF04430.14): Protein of unknown function (DUF498/DUF598) (109 a.a.), 14 papers
IPR007523: NDUFAF3/AAMDC. This entry includes NDUFAF3, an essential factor for the assembly of mitochondrial NADH:ubiquinone oxidoreductase complex (complex I), and the Mth938 domain-containing protein. The crystal structure of NDUFAF3 revealed a 3-layer beta+alpha/beta/alpha topology. NADH:ubiquinone oxidoreductase (complex I) is a respiratory-chain enzyme that catalyses the transfer of two electrons from NADH to ubiquinone in a reaction that is associated with proton...
Overlapping families in CDD: COG1504, COG3737, Mth938, Mth938-like superfamily, Mth938_2P1-like

Members of DUF498 whose function may be known:

DUF1768 (PF08719.11): Domain of unknown function (DUF1768) (161 a.a.), 14 papers
IPR012816: NADAR. This family contains E. coli swarming motility protein YbiA. Mutations in YbiA cause defects in Escherichia coli swarming, but not necessarily in motility. This family was predicted to be involved in NAD-utilizing pathways, likely to act on ADP-ribose derivatives, and was been named NADAR (NAD and ADP-ribose). More recently, YbiA has been shown to be involved in the disposal...
Overlapping families in CDD: NADAR, NADAR superfamily, ribofla_fusion, ybiA

Members of DUF1768 whose function may be known:

DUF1794 (PF08768.11): Domain of unknown function (DUF1794) (149 a.a.), 14 papers
IPR014878: DUF1794. Nitrobindin is a heme-containing lipocalin that may reversibly bind nitric oxide. This heme-binding domain forms a beta barrel structure, and in a small family of proteins from tetrapods, it is found C-terminal to a THAP zinc finger domain (a sequence-specific DNA binding domain). Members of this group are putatively related to fatty acid-binding proteins (FABPs).
Overlapping families in CDD: EGF, EGF_CA, EGF_CA superfamily, nitrobindin, nitrobindin superfamily

Members of DUF1794 whose function may be known:

ABC_transp_aux (PF09822.9): ABC-type uncharacterized transport system (267 a.a.), 14 papers
IPR019196: ABC_transp_unknown. This domain is found in various eukaryotic and prokaryotic intra-flagellar transport proteins involved in gliding motility, as well as in several hypothetical proteins.

Members of ABC_transp_aux whose function may be known:

DUF2420 (PF10336.9): Protein of unknown function (DUF2420) (108 a.a.), 14 papers
IPR018822: UPF0646. This entry represents a family of proteins conserved in fungi. Their function is not known.

Members of DUF2420 whose function may be known:

DUF2431 (PF10354.9): Domain of unknown function (DUF2431) (168 a.a.), 14 papers
IPR019446: DUF2431. This entry represents the N-terminal domain of a family of proteins whose function is not known.
Overlapping families in CDD: AdoMet_MTases superfamily

Members of DUF2431 whose function may be known:

DUF188 (PF02639.14): Uncharacterized BCR, YaiI/YqxD family COG1671 (130 a.a.), 13 papers
IPR003791: UPF0178. This entry describes proteins of unknown function.
Overlapping families in CDD: PRK00124, YaiI

Members of DUF188 whose function may be known:

DUF440 (PF04269.12): Protein of unknown function, DUF440 (101 a.a.), 13 papers
IPR007376: dsDNA_mimic_put. This entry represents hypothetical proteins such as HI1450, which is believed to act as a putative dsDNA mimic. HI1450 is an acidic protein with a core structure consisting of alpha(2)-beta(4), where the alpha-helices are packed against the side of an anti-parallel 4-stranded beta meander. As such, it has some similarity to the dsDNA mimics uracil-DNA glycosylase inhibitor and nuclease...
Overlapping families in CDD: PRK05094, YciU

Members of DUF440 whose function may be known:

DUF488 (PF04343.13): Protein of unknown function, DUF488 (122 a.a.), 13 papers
IPR007438: DUF488. This family includes several proteins of uncharacterised function.
Overlapping families in CDD: YeaO

Members of DUF488 whose function may be known:

DUF725 (PF05267.12): Protein of unknown function (DUF725) (121 a.a.), 13 papers
IPR007931: TsetseEP. This domain can be found in tsetseEP, a gut protein from the tsetse Glossina morsitans. Towards the C terminus, the protein contains 59 (EP) repeats.

Members of DUF725 whose function may be known:

DUF934 (PF06073.12): Bacterial protein of unknown function (DUF934) (107 a.a.), 13 papers
IPR008318: UCP030820. There are currently no experimental data for members of this group or their homologues, nor do they exhibit features indicative of any function.
Overlapping families in CDD: COG3749

Members of DUF934 whose function may be known:

DUF945 (PF06097.11): Bacterial protein of unknown function (DUF945) (460 a.a.), 13 papers
IPR010352: DUF945. This entry consists of several hypothetical bacterial proteins of unknown function.
Overlapping families in CDD: PRK11367, YdgA

Members of DUF945 whose function may be known:

DUF1077 (PF06417.12): Protein of unknown function (DUF1077) (118 a.a.), 13 papers
IPR009445: TMEM85/Emc4. This entry includes TMEM85 from mammals and Emc4 from budding yeasts. They inhibit hydrogen peroxide mediated cell death in yeast. Emc4 is part of the ER membrane complex (EMC) that may play a role in protein folding.

Members of DUF1077 whose function may be known:

DUF1233 (PF06806.12): Putative excisionase (DUF1233) (70 a.a.), 13 papers
IPR009634: Put_exci. This family consists of several putative phage and prophage excisionase proteins of around 80 residues in length.

Members of DUF1233 whose function may be known:

DUF1266 (PF06889.11): Protein of unknown function (DUF1266) (176 a.a.), 13 papers
IPR009677: DUF1266. This family consists of several hypothetical bacterial proteins of unknown function.
Overlapping families in CDD: PRK11380

Members of DUF1266 whose function may be known:

DUF1425 (PF07233.12): Protein of unknown function (DUF1425) (92 a.a.), 13 papers
IPR010824: DUF1425. This family consists of several hypothetical bacterial proteins of around 125 residues in length. Several members of this family are described as putative lipoproteins and are often known as YcfL. The function of this family is unknown.
Overlapping families in CDD: YcfL

Members of DUF1425 whose function may be known:

DUF1689 (PF07954.11): Protein of unknown function (DUF1689) (146 a.a.), 13 papers
IPR012470: Pup1-like. This entry represents a group of fungal proteins, including Pup1 from Candida glabrata. Pup1 is a mitochondrial protein that contributes to the enhanced virulence of C.glabrata strains that acquired azole resistance.

Members of DUF1689 whose function may be known:

DUF1722 (PF08349.11): Protein of unknown function (DUF1722) (117 a.a.), 13 papers
IPR013560: DUF1722. This domain of unknown function is found in bacteria and archaea and is homologous to the hypothetical protein ybgA from Escherichia coli .
Overlapping families in CDD: PRK10167, YbgA

Members of DUF1722 whose function may be known:

DUF2313 (PF10076.9): Uncharacterised protein conserved in bacteria (DUF2313) (163 a.a.), 13 papers
IPR018755: Phage_Mu_Gp48. Members of this family of proteins comprise various hypothetical and putative bacteriophage tail proteins, including Gp48 from Bacteriophage Mu and other Mu-like prophages such as FluMu.
Overlapping families in CDD: YmfQ

Members of DUF2313 whose function may be known:

DUF3602 (PF12223.8): Protein of unknown function (DUF3602) (81 a.a.), 13 papers
IPR022024: DUF3602. This domain family is found in eukaryotes, and is typically between 78 and 89 amino acids in length. This entry include protein Par32 from Saccharomyces cerevisiae. Par32 is hyperphosphorylated after treatment with rapamycin in a TAP42-dependent manner. It is also involved in resistance to cisplatin.

Members of DUF3602 whose function may be known:

DUF4065 (PF13274.6): Protein of unknown function (DUF4065) (114 a.a.), 13 papers
IPR025272: DUF4065. This presumed domain is functionally uncharacterised.
Overlapping families in CDD: GepA

Members of DUF4065 whose function may be known:

DUF4772 (PF15997.5): Domain of unknown function (DUF4772) (117 a.a.), 13 papers
IPR031940: DUF4772. This presumed domain is functionally uncharacterised. This domain is found in eukaryotes, and is typically between 107 and 124 amino acids in length. There is a single completely conserved residue V that may be functionally important.

Members of DUF4772 whose function may be known:

DUF4922 (PF16269.5): Domain of unknown function (DUF4922) (193 a.a.), 13 papers
Overlapping families in CDD: PLN03103

Members of DUF4922 whose function may be known:

DUF417 (PF04224.12): Protein of unknown function, DUF417 (175 a.a.), 12 papers
IPR007339: RclC-like. This family of uncharacterised proteins appears to be restricted to proteobacteria. It includes inner membrane protein RclC (YkgD) from Escherichia coli , which is a reactive chlorine-specific transcription factor.
Overlapping families in CDD: YkgB

Members of DUF417 whose function may be known:

DUF418 (PF04235.12): Protein of unknown function (DUF418) (163 a.a.), 12 papers
IPR007349: DUF418. This domain of unknown function is found in probable integral membrane proteins.
Overlapping families in CDD: PRK10835, YeiB, YeiB superfamily

Members of DUF418 whose function may be known:

DUF496 (PF04363.12): Protein of unknown function (DUF496) (93 a.a.), 12 papers
IPR007458: DUF496. Members of this family are uncharacterised proteins.
Overlapping families in CDD: PRK05423, YeeX

Members of DUF496 whose function may be known:

DUF600 (PF04634.12): Protein of unknown function, DUF600 (146 a.a.), 12 papers
IPR006728: DUF600. Proteins in this entry include the YezG protein from Bacillus subtilis. YezG is probably the antitoxin component of a toxin-antitoxin (TA) module.
Overlapping families in CDD: staph_tand_hypo

Members of DUF600 whose function may be known:

DUF647 (PF04884.14): Vitamin B6 photo-protection and homoeostasis (241 a.a.), 12 papers
IPR006968: RUS_fam. This family is composed of root UVB sensitive proteins and their homologues. In Arabidopsis thaliana, proteins in this family are involved in UVB-sensing and in early seedling morphogenesis and development.

Members of DUF647 whose function may be known:

DUF667 (PF05018.13): Protein of unknown function (DUF667) (185 a.a.), 12 papers
IPR007714: CFA20_dom. This domain is characteristic of cilia- and flagella-associated protein 20 (CFA20). CFA20 is a cilium- and flagellum-specific protein that plays a role in axonemal structure organisation and motility. In Chlamydomonas reinhardtii, it stabilises outer doublet microtubules (DMTs) of the axoneme and may work as a scaffold for intratubular proteins, such as tektin and PACRG, to produce the beak structures...

Members of DUF667 whose function may be known:

UPF0220 (PF05255.11): Uncharacterised protein family (UPF0220) (166 a.a.), 12 papers
IPR007919: UPF0220. This family of proteins is functionally uncharacterised.

Members of UPF0220 whose function may be known:

DUF761 (PF05553.11): Cotton fibre expressed protein (36 a.a.), 12 papers
IPR008480: DUF761_pln. This family consists of several plant proteins of unknown function, including pathogen-associated molecular patterns-induced protein A70 from Arabidopsis thaliana, which is induced during Pseudomonas syringae infection by jasmonic acid and wounding.
Overlapping families in CDD: DUF4408, DUF4408 superfamily

Members of DUF761 whose function may be known:

DUF1107 (PF06526.12): Protein of unknown function (DUF1107) (63 a.a.), 12 papers
IPR009491: DUF1107. This family consists of several short, hypothetical bacterial proteins of unknown function.

Members of DUF1107 whose function may be known:

DUF1161 (PF06649.12): Protein of unknown function (DUF1161) (52 a.a.), 12 papers
IPR010595: DUF1161. This family consists of several short, hypothetical bacterial proteins of unknown function.

Members of DUF1161 whose function may be known:

DUF1211 (PF06736.11): Protein of unknown function (DUF1211) (85 a.a.), 12 papers
IPR010617: TMEM175. In animals, TMEM175 is an organelle-specific potassium channel specifically responsible for potassium conductance in endosomes and lysosomes. It forms a potassium-permeable leak-like channel, which regulates lumenal pH stability and is required for autophagosome-lysosome fusion. TMEM175 is the major lysosomal K+ conductance. This entry also includes TMEM175 homologues from bacteria and archaea.
Overlapping families in CDD: COG3548

Members of DUF1211 whose function may be known:

DUF1320 (PF07030.12): Protein of unknown function (DUF1320) (126 a.a.), 12 papers
IPR009752: Phage_Mu_Gp36. This entry is represented by the Bacteriophage Mu, Gp36. The characteristics of the protein distribution suggest prophage matches in addition to the phage matches.
Overlapping families in CDD: gp436

Members of DUF1320 whose function may be known:

DUF1327 (PF07041.11): Protein of unknown function (DUF1327) (113 a.a.), 12 papers
IPR009759: Phage_ES18_Gp24. This entry is represented by Bacteriophage ES18, Gp24. The characteristics of the protein distribution suggest prophage matches in addition to the phage matches. This family consists of several hypothetical bacterial proteins of around 115 residues in length, which seem to be specific to Escherichia coli . The function of this family is unknown.

Members of DUF1327 whose function may be known:

DUF1482 (PF07358.11): Protein of unknown function (DUF1482) (57 a.a.), 12 papers
IPR009954: DUF1482. This family consists of several Enterobacterial proteins of around 60 residues in length. The function of this family is unknown.

Members of DUF1482 whose function may be known:

DUF1681 (PF07933.14): Protein of unknown function (DUF1681) (148 a.a.), 12 papers
IPR012466: NECAP_PHear. This PH-like domain can be found in the N-terminal region of NECAPs (also known as adaptin ear-binding coat-associated proteins). NECAPs are alpha-ear-binding proteins that enrich on clathrin-coated vesicles (CCVs). NECAP-1 is expressed in brain and non-neuronal tissues and cells while NECAP-2 is ubiquitously expressed. The PH-like domain of NECAPs is a protein-binding interface that mimics the FxDxF motif binding...
Overlapping families in CDD: DNA_pol3_delta2 superfamily, PH-like superfamily, PHear_NECAP, PRK14959, PRK14971

Members of DUF1681 whose function may be known:

DUF1690 (PF07956.11): Protein of Unknown function (DUF1690) (139 a.a.), 12 papers
IPR012471: DUF1690. Family of uncharacterised fungal proteins.

Members of DUF1690 whose function may be known:

Cg6151-P (PF10233.9): Uncharacterized conserved protein CG6151-P (113 a.a.), 12 papers
IPR019365: TVP18/Ca-channel_flower. This is a family of small (less than 200 residue long) proteins that are conserved from fungi to humans. Family members include the TVP18 Golgi membrane proteins that are involved in vesicular trafficking and the calcium channel flower proteins, which form calcium channels that regulate synaptic endocytosis.

Members of Cg6151-P whose function may be known:

DUF2890 (PF11081.8): Protein of unknown function (DUF2890) (168 a.a.), 12 papers
IPR021304: Adeno_L4-33K/L4-22K. Adenoviruses express up to 20 distinct mRNAs from five major late transcription unit (MLTU) regions, L1 to L5. The L4 region expresses L4-33K and a related protein, L4-22K. L4-22K and L4-33K have complementary but not redundant functions that provide the normal pattern of mRNA production during the late phase of infection. L4-33K is an alternative RNA splicing factor that...
Overlapping families in CDD: Marek_A superfamily, PHA03269

Members of DUF2890 whose function may be known:

DUF3699 (PF12480.8): Protein of unknown function (DUF3699) (71 a.a.), 12 papers
IPR022168: DUF3699. This domain family is found in eukaryotes, and is approximately 80 amino acids in length.
Overlapping families in CDD: PRK13875, PRK13875 superfamily, TrbL, TrbL superfamily

Members of DUF3699 whose function may be known:

DUF3767 (PF12597.8): Protein of unknown function (DUF3767) (101 a.a.), 12 papers
IPR022533: Cox20. Complex IV (CIV) is a copper-heme oxidase that couples electron transfer from cytochrome c to oxygen with proton extrusion across the inner membrane to contribute to the proton gradient required for ATP generation. This entry includes fungal mitochondrial complex IV assembly factor Cox20 and its homologues (also known as (FAM36A) in metazoa. Human CIV is formed by three catalytic...

Members of DUF3767 whose function may be known:

DUF413 (PF04219.12): Protein of unknown function, DUF (90 a.a.), 11 papers
IPR007335: DUF413. This is a family of uncharacterised proteins.
Overlapping families in CDD: PRK11027, YifE

Members of DUF413 whose function may be known:

DUF463 (PF04317.12): YcjX-like family, DUF463 (444 a.a.), 11 papers
IPR007413: DUF463_YcjX. This family of proteins appear to possess a P-loop motif and may therefore bind ATP or GTP.
Overlapping families in CDD: YcjX

Members of DUF463 whose function may be known:

DUF533 (PF04391.12): Protein of unknown function (DUF533) (179 a.a.), 11 papers
IPR007486: YebE. Some family members may be secreted or integral membrane proteins. This entry includes the inner membrane protein YebE from Escherichia coli.
Overlapping families in CDD: YebE, terB_like superfamily, terB_like_YebE

Members of DUF533 whose function may be known:

DUF640 (PF04852.12): Protein of unknown function (DUF640) (126 a.a.), 11 papers
IPR006936: ALOG_dom. The 125-residue ALOG (Arabidopsis LSH1 and oryza G1) domain is rich in basic amino acids, especially arginine, and is highly conserved among land plants. Members of the ALOG family of proteins function as key developmental regulators. It has been proposed that the ALOG domain originated from the N- terminal DNA-binding domains of integrases belonging to the tyrosine recombinase superfamily...

Members of DUF640 whose function may be known:

DUF760 (PF05542.11): Protein of unknown function (DUF760) (84 a.a.), 11 papers
IPR008479: DUF760. This entry represents a family of uncharacterised proteins, including chloroplastic UV-B-induced protein At3g17800 from Arabidopsis.

Members of DUF760 whose function may be known:

DUF812 (PF05667.11): Protein of unknown function (DUF812) (595 a.a.), 11 papers
IPR008530: CCDC22. Human coiled-coil domain-containing protein 22 (CCDC22) is involved in regulation of NF-kappa-B signalling; the function may involve association with COMMD8 and a CUL1-dependent E3 ubiquitin ligase complex. It is part of the OMMD/CCDC22/CCDC93 (CCC) complex, which interacts with the multisubunit WASH complex required for endosomal deposition of F-actin and cargo trafficking in conjunction with the retromer. This entry also...
Overlapping families in CDD: PRK03918, SMC_N superfamily, SMC_prok_B, SbcC, Smc

Members of DUF812 whose function may be known:

DUF1264 (PF06884.11): Protein of unknown function (DUF1264) (171 a.a.), 11 papers
IPR010686: OBAP-like. This entry includes a group of oil body associated proteins (OBAPs) from plants and some uncharacterised proteins from fungi and bacteria. The plant obap proteins are predominantly expressed during embryo development and may be involved in the stability of oil bodies.

Members of DUF1264 whose function may be known:

DUF1735 (PF08522.10): Domain of unknown function (DUF1735) (120 a.a.), 11 papers
IPR013728: DUF1735. This domain of unknown function is found in a number of bacterial proteins including acylhydrolases.
Overlapping families in CDD: GH18_EndoS-like, GH18_chitinase-like superfamily, Glyco_hydro_18, Glyco_hydro_18 superfamily

Members of DUF1735 whose function may be known:

DUF1864 (PF08933.11): Domain of unknown function (DUF1864) (387 a.a.), 11 papers
IPR015029: DUF1864. This protein has no known function. It is found in various hypothetical and conserved domain proteins.
Overlapping families in CDD: IDO superfamily

Members of DUF1864 whose function may be known:

KxDL (PF10241.9): Uncharacterized conserved protein (86 a.a.), 11 papers
IPR019371: Uncharacterised_KxDL. This entry represents a conserved region of 80 residues which defines a family of short proteins. There is a characteristic KxDL motif towards the C terminus. The function is unknown.

Members of KxDL whose function may be known:

DUF2034 (PF10356.9): Protein of unknown function (DUF2034) (185 a.a.), 11 papers
IPR018828: DUF2034. This protein is expressed mainly in fungi but its function is unknown.
Overlapping families in CDD: Restriction_endonuclease_like superfamily

Members of DUF2034 whose function may be known:

DUF3367 (PF11847.8): Alpha-(1->3)-arabinofuranosyltransferase (667 a.a.), 11 papers
IPR021798: AftD. Alpha-(1->3)-arabinofuranosyltransferase is involved in the biosynthesis of the arabinogalactan (AG) region of the mycolylarabinogalactan-peptidoglycan (mAGP) complex, an essential component of the mycobacterial cell wall. It catalyzes the addition of an arabinofuranosyl (Araf) residue from the sugar donor decaprenyl-phospho-arabinose (DPA) on the C-3 of an alpha-(1->5)-linked Araf from the arabinan backbone of AG.
Overlapping families in CDD: F5_F8_type_C, F5_F8_type_C superfamily

Members of DUF3367 whose function may be known:

DUF3592 (PF12158.8): Protein of unknown function (DUF3592) (149 a.a.), 11 papers
IPR021994: DUF3592. This family of proteins is functionally uncharacterised.This family of proteins is found in bacteria, archaea, eukaryotes and viruses. Proteins in this family are typically between 150 and 242 amino acids in length.

Members of DUF3592 whose function may be known:

DUF3730 (PF12530.8): Protein of unknown function (DUF3730) (229 a.a.), 11 papers
IPR022542: DUF3730. This domain is found in eukaryotes, and is typically between 220 and 262 amino acids in length.

Members of DUF3730 whose function may be known:

DUF3987 (PF13148.6): Protein of unknown function (DUF3987) (365 a.a.), 11 papers
IPR025048: DUF3987. This entry represents a family of uncharacterised proteins that was originally found by clustering human gut metagenomic sequences.

Members of DUF3987 whose function may be known:

DUF92 (PF01940.16): Integral membrane protein DUF92 (236 a.a.), 10 papers
IPR002794: DUF92_TMEM19. Many members of this family have no known function and are predicted to be integral membrane proteins. One member of the family has been characterised as Protein PGR (AtPGR). PGR is suggested to be a potential glucose-responsive regulator in carbohydrate metabolism in plants.
Overlapping families in CDD: COG1836, TIGR00297

Members of DUF92 whose function may be known:

DUF615 (PF04751.14): Protein of unknown function (DUF615) (154 a.a.), 10 papers
IPR006839: Ribosome-assoc_YjgA. The proteins in this entry are functionally uncharacterised. The entry contains the Escherichia coli (strain K12) protein YjgA, which has been shown to comigrate with the mature 50S ribosome subunit. Therefore it either represents a novel ribosome-associated protein or it is associated with a different oligomeric complex that comigrates with ribosomal particles.
Overlapping families in CDD: PRK05255, YjgA, YjgA-like, YjgA-like superfamily

Members of DUF615 whose function may be known:

DUF617 (PF04759.13): Protein of unknown function, DUF617 (163 a.a.), 10 papers
IPR006460: MIZ1-like_pln. This entry includes Arabidopsis MIZU-KUSSEI 1 (MIZ1), which is an essential protein for hydrotropism in roots. It can be regulated by light signal and ABA signalling.
Overlapping families in CDD: A_thal_3588

Members of DUF617 whose function may be known:

DUF1018 (PF06252.12): Protein of unknown function (DUF1018) (119 a.a.), 10 papers
IPR009363: Phage_Mu_Gp16. This family consists of several bacterial and phage proteins, related to Gp16 of phage Mu, of unknown function.
Overlapping families in CDD: gp16

Members of DUF1018 whose function may be known:

DUF1043 (PF06295.12): Protein of unknown function (DUF1043) (123 a.a.), 10 papers
IPR009386: DUF1043. This entry consists of several hypothetical bacterial proteins of unknown function.
Overlapping families in CDD: PRK11677, YhcB

Members of DUF1043 whose function may be known:

DUF1084 (PF06454.11): Protein of unknown function (DUF1084) (273 a.a.), 10 papers
IPR009457: DUF1084. This entry consists of several hypothetical plant specific proteins of unknown function.

Members of DUF1084 whose function may be known:

DUF1187 (PF06688.11): Protein of unknown function (DUF1187) (61 a.a.), 10 papers
IPR009572: DUF1187. This family consists of several short, hypothetical bacterial proteins of around 62 residues in length. Members of this family are found in Escherichia coli and Salmonella typhi . The function of this family is unknown.
Overlapping families in CDD: PRK09750

Members of DUF1187 whose function may be known:

DUF1296 (PF06972.11): Protein of unknown function (DUF1296) (60 a.a.), 10 papers
IPR009719: GIP1. This entry represents a group of plant proteins, including GBF1-interacting protein 1 (GIP1, AT3G13222) from Arabidopsis. GIP1 may act as a coactivator that regulates transcription factors involved in lateral organ development of plants, such as bZIP transcription factors and LBD18.

Members of DUF1296 whose function may be known:

DUF1397 (PF07165.11): Protein of unknown function (DUF1397) (203 a.a.), 10 papers
IPR009832: DUF1397. This entry consists of several insect specific 27 kDa Haemolymph glycoprotein precursors. The function of this family is unknown.

Members of DUF1397 whose function may be known:

DUF1451 (PF07295.11): Zinc-ribbon containing domain (147 a.a.), 10 papers
IPR009912: DUF1451. This family consists of several hypothetical bacterial proteins of around 160 residues in length. Members of this family contain four highly conserved cysteine resides toward the C-terminal region of the protein.
Overlapping families in CDD: PRK11032

Members of DUF1451 whose function may be known:

DUF2263 (PF10021.9): Uncharacterized protein conserved in bacteria (DUF2263) (146 a.a.), 10 papers
IPR019261: DUF2263. This domain, found in various hypothetical bacterial and eukaryotic proteins, has no known function.
Overlapping families in CDD: COG4295, COG4295 superfamily, TIGR02452

Members of DUF2263 whose function may be known:

DUF2303 (PF10065.9): Uncharacterized conserved protein (DUF2303) (267 a.a.), 10 papers
IPR019276: DUF2303. Proteins in this entry are uncharacterised. The characteristics of the protein distribution suggest prophage matches in addition to the phage matches.
Overlapping families in CDD: yfdQ

Members of DUF2303 whose function may be known:

DUF2205 (PF10224.9): Short coiled-coil protein (75 a.a.), 10 papers
IPR019357: SCOC. This entry represents short coiled-coil protein (SCOC). In human, SCOC is required for autophagosome formation during amino acid starvation. It forms a starvation-sensitive trimeric complex with UVRAG (UV radiation resistance associated gene) and FEZ1 and may regulate ULK1 and Beclin 1 complex activities.

Members of DUF2205 whose function may be known:

DUF2527 (PF10736.9): Protein of unknown function (DUF2627) (38 a.a.), 10 papers
IPR019672: DUF2527. This entry represents small proteins with unknown function and appear to be restricted to a family of Enterobacterial proteins. It has a highly conserved sequence. Some proteins are annotated as YobF and may be involved in stress responses in E. coli.

Members of DUF2527 whose function may be known:

DUF2587 (PF10759.9): Protein of unknown function (DUF2587) (160 a.a.), 10 papers
IPR019695: Proteasome_act. This is a family of bacterial proteasome cofactors. The family member from Mycobacterium tuberculosis, protein Rv3780, was shown to form rings and cap proteasome core particles. It enhanced peptide and protein degradation by proteasomes in an adenosine triphosphate (ATP)-independent manner, promoting degradation of the heat shock protein repressor HspR.
Overlapping families in CDD: PRK12469, Sigma54_CBD superfamily

Members of DUF2587 whose function may be known:

DUF2946 (PF11162.8): Protein of unknown function (DUF2946) (115 a.a.), 10 papers
IPR021333: DUF2946. This family of proteins has no known function.

Members of DUF2946 whose function may be known:

DUF3507 (PF12015.8): Domain of unknown function (DUF3507) (182 a.a.), 10 papers
IPR021895: Bud3_N. This domain is found in the N-terminal of the yeast Bud3 protein. Bud3 is involved in bud-site selection in budding yeasts. This domain has a conserved ENL sequence motif.
Overlapping families in CDD: RhoGEF, RhoGEF superfamily

Members of DUF3507 whose function may be known:

DUF4033 (PF13225.6): Domain of unknown function (DUF4033) (89 a.a.), 10 papers
IPR025114: DUF4033. This presumed domain is functionally uncharacterised.

Members of DUF4033 whose function may be known:

DUF4156 (PF13698.6): Domain of unknown function (DUF4156) (91 a.a.), 10 papers
IPR025294: DUF4156. The function of this family is unknown but some members are annotated as putative lipoprotein outer membrane proteins.

Members of DUF4156 whose function may be known:

DUF43 (PF01861.16): Branched-chain polyamine synthase A C-terminal domain (243 a.a.), 9 papers
IPR002723: BpsA_C. This domain is found in the C terminus of N(4)-bis(aminopropyl)spermidine synthase (BpsA) from hyperthermophiles and in uncharacterised proteins from bacteria and archaea.
Overlapping families in CDD: AdoMet_MTases, AdoMet_MTases superfamily, COG1568, COG1568 superfamily

Members of DUF43 whose function may be known:

DUF167 (PF02594.16): Uncharacterised ACR, YggU family COG1872 (77 a.a.), 9 papers
IPR003746: DUF167. This entry describes proteins of unknown function. Structures for two of these proteins, YggU from Escherichia coli and MTH637 from the archaea Methanobacterium thermoautotrophicum , have been determined; they have a core 2-layer alpha/beta structure consisting of beta(2)-loop-alpha-beta(2)-alpha.
Overlapping families in CDD: PRK05090, TIGR00251, YggU

Members of DUF167 whose function may be known:

DUF350 (PF03994.14): Domain of Unknown Function (DUF350) (54 a.a.), 9 papers
IPR007140: DUF350. This motif occurs in a small set of bacterial proteins. It has two transmembrane regions, and often occurs as tandem repeats. The are no conserved catalytic residues.
Overlapping families in CDD: YjfL

Members of DUF350 whose function may be known:

DUF502 (PF04367.13): Protein of unknown function (DUF502) (106 a.a.), 9 papers
IPR007462: DUF502. This entry contains proteins that are predicted to be integral membrane proteins.
Overlapping families in CDD: COG2928

Members of DUF502 whose function may be known:

DUF966 (PF06136.13): Domain of unknown function (DUF966) (377 a.a.), 9 papers
IPR010369: DUF966. This is a family of plant proteins confined to monocotyledons and mosses, with unknown function

Members of DUF966 whose function may be known:

DUF999 (PF06198.11): Protein of unknown function (DUF999) (143 a.a.), 9 papers
IPR009340: DUF999. This is a family of conserved Schizosaccharomyces proteins with unknown function.
Overlapping families in CDD: HAD_like superfamily, P-type_ATPase_HM

Members of DUF999 whose function may be known:

DUF1075 (PF06388.11): Protein of unknown function (DUF1075) (121 a.a.), 9 papers
IPR009432: DUF1075. This family consists of several eukaryotic proteins of unknown function.

Members of DUF1075 whose function may be known:

DUF1190 (PF06693.11): Protein of unknown function (DUF1190) (161 a.a.), 9 papers
IPR009576: Biofilm_formation_YgiB. The proteins in this entry, which include YgiB, are functionally uncharacterised, however, transcription of ygiB is induced upon biofilm formation compared to planktonic growth in both exponential and stationary phase. Induction of expression was found to be dependent on the presence of the F plasmid. Biofilm formation is impaired in mutants of ygiB.
Overlapping families in CDD: PRK11653, YgiB

Members of DUF1190 whose function may be known:

DUF1213 (PF06740.12): Protein of unknown function (DUF1213) (33 a.a.), 9 papers
IPR009603: MAP_Futsch. The Drosophila protein Futsch has homology to MAP1B and controls synaptic growth at the Drosophila neuromuscular junction through the regulation of the synaptic microtubule cytoskeleton. Futsch protein colocalises with microtubules and identifies cytoskeletal loops that traverse the lateral margin of select synaptic boutons. Futsch mutations disrupt synaptic microtubule organisation, reduce bouton number, and increase bouton size. These deficits can...
Overlapping families in CDD: AF-4, AF-4 superfamily, Aim21, DUF4775 superfamily, Herpes_BLLF1, Herpes_BLLF1 superfamily, LGT superfamily, MDN1, MDN1 superfamily, Neuromodulin_N superfamily, PRK13108, PTZ00121, SMC_N, SMC_N superfamily, TolA, V-ATPase_G_2 superfamily, XPG_I superfamily, rad2

Members of DUF1213 whose function may be known:

UPF0240 (PF06784.11): Uncharacterised protein family (UPF0240) (174 a.a.), 9 papers
IPR009622: NDUFAF4. NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 4 (NDUFAF4, also known as HRPAP20) is involved in the assembly of mitochondrial NADH:ubiquinone oxidoreductase complex (complex I). It may be involved in cell proliferation and survival of hormone-dependent tumor cells.

Members of UPF0240 whose function may be known:

DUF1283 (PF06932.11): Protein of unknown function (DUF1283) (83 a.a.), 9 papers
IPR009700: DUF1283. This family consists of several hypothetical proteins of around 115 residues in length, which seem to be specific to Enterobacteria. The function of the family is unknown.
Overlapping families in CDD: PRK13659

Members of DUF1283 whose function may be known:

DUF1289 (PF06945.13): Protein of unknown function (DUF1289) (48 a.a.), 9 papers
IPR010710: DUF1289. This family consists of a number of hypothetical bacterial proteins. The aligned region spans around 56 residues and contains 4 highly conserved cysteine residues towards the N terminus. The function of this family is unknown.
Overlapping families in CDD: YdhL

Members of DUF1289 whose function may be known:

DUF1315 (PF07023.12): Protein of unknown function (DUF1315) (82 a.a.), 9 papers
IPR009749: DUF1315. This family consists of several bacterial proteins of around 90 residues in length. The function of this family is unknown.
Overlapping families in CDD: yeaC

Members of DUF1315 whose function may be known:

DUF1414 (PF07208.11): Protein of unknown function (DUF1414) (44 a.a.), 9 papers
IPR009857: UPF0352. This family consists of several hypothetical bacterial proteins of around 70 residues in length. Members of this family are often referred to as YejL. The function of this family is unknown.
Overlapping families in CDD: PRK13689, YejL

Members of DUF1414 whose function may be known:

DUF2043 (PF09740.9): Uncharacterized conserved protein (DUF2043) (106 a.a.), 9 papers
IPR018610: UVSSA. UVSSA is part of a UV-induced ubiquitinated protein complex involved in transcription-coupled nucleotide excision repair (TC-NER) in response to UV damage. It stabilise the TC-NER master organizing protein ERCC6 (also known as CSB) by delivering the deubiquitinating enzyme USP7 to TC-NER complexes.

Members of DUF2043 whose function may be known:

DUF2135 (PF09906.9): Uncharacterized protein conserved in bacteria (DUF2135) (52 a.a.), 9 papers
IPR019220: DUF2135. This entry, found in various hypothetical prokaryotic proteins, has no known function.
Overlapping families in CDD: YfaP

Members of DUF2135 whose function may be known:

DUF2151 (PF10221.9): Cell cycle and development regulator (688 a.a.), 9 papers
IPR019355: Cell_cycle_regulator_Mat89Bb. This entry represents the cell cycle regulator Mat89b (also known as protein asunder), which plays an evolutionarily conserved role as a crucial regulator of both cell cycle and development. Mat89Bb is a PNG kinase substrate that is essential for S-M cycles of early Drosophila embryogenesis, Xenopus embryonic cell cycles and morphogenesis, and cell division in cultured mammalian cells.

Members of DUF2151 whose function may be known:

DUF5427 (PF10310.9): Family of unknown function (DUF5427) (465 a.a.), 9 papers
IPR018814: DUF5427. In Saccharomyces cerevisiae, maintenance of telomere capping protein 1 (Mtc1) may interact with ribosomes and is synthetically lethal with cdc13-1 .
Overlapping families in CDD: Mtc1, Mtc1 superfamily

Members of DUF5427 whose function may be known:

DUF2520 (PF10728.9): Domain of unknown function (DUF2520) (127 a.a.), 9 papers
IPR018931: DUF2520. This presumed domain is found C-terminal to a Rossmann-like domain suggesting that these proteins are oxidoreductases.

Members of DUF2520 whose function may be known:

DUF3029 (PF11230.8): Protein of unknown function (DUF3029) (485 a.a.), 9 papers
IPR016905: Glycyl_radical_HI0521_prd. Members of this family are homologues to enzymes known to undergo activation by a radical SAM protein to create an active site glycyl radical. This family appears to be activated by the YjjW radical SAM protein, usually encoded by an adjacent gene.
Overlapping families in CDD: PRK10977, glycyl_YjjI

Members of DUF3029 whose function may be known:

DUF3251 (PF11622.8): Protein of unknown function (DUF3251) (165 a.a.), 9 papers
IPR021658: DUF3251. This entry represents a domain found in a group of bacterial lipoproteins, such as SadB from Salmonella typhimurium. SadB is required for proper surface expression of the autotransporter adhesin SadA.
Overlapping families in CDD: CwlO1, CwlO1 superfamily

Members of DUF3251 whose function may be known:

DUF3254 (PF11630.8): Protein of unknown function (DUF3254) (100 a.a.), 9 papers
IPR024509: Anti-LPS_factor/Scygonadin. Anti-lipopolysaccharide factor binds to bacterial LPS and may specifically inhibit the LPS-mediated activation of the hemolymph coagulation. It has a strong antibacterial effect, especially on the growth of Gram-negative bacteria. This entry also includes the antibacterial protein Scygonadin, which has antibacterial activity against the Gram-positive bacterium Micrococcus luteus.

Members of DUF3254 whose function may be known:

DUF3313 (PF11769.8): Protein of unknown function (DUF3313) (186 a.a.), 9 papers
IPR021747: DUF3313. This a bacterial family of proteins which are annotated as putative lipoproteins.

Members of DUF3313 whose function may be known:

DUF3419 (PF11899.8): Protein of unknown function (DUF3419) (385 a.a.), 9 papers
IPR021829: DUF3419. This family of proteins are functionally uncharacterised. This protein is found in bacteria and eukaryotes. Proteins in this family are typically between 398 to 802 amino acids in length.
Overlapping families in CDD: BtaA

Members of DUF3419 whose function may be known:

DUF3611 (PF12263.8): Protein of unknown function (DUF3611) (177 a.a.), 9 papers
IPR022051: DUF3611. This entry represents a group of proteins mostly from plants and Cyanobacteria (blue-green algae), including TIC21 from Arabidopsis. TIC21 is Involved in chloroplast protein import across the inner envelope membrane. It can acts as a chloroplast permease regulating the iron transport and homeostasis.
Overlapping families in CDD: SLAIN, SLAIN superfamily

Members of DUF3611 whose function may be known:

DUF3828 (PF12883.7): Protein of unknown function (DUF3828) (122 a.a.), 9 papers
IPR024289: DUF3828. This domain currently has no known function.
Overlapping families in CDD: PRK10533

Members of DUF3828 whose function may be known:

UPF0172 (PF03665.13): Uncharacterised protein family (UPF0172) (191 a.a.), 8 papers
IPR005366: EMC8/9. Saccharomyces cerevisiae ER membrane protein complex (EMC) comprises six subunits. Four and three additional subunits have been identified in mammals and Drosophila, respectively. EMC is required for protein folding in the endoplasmic reticulum (ER). It also facilitates lipid transfer from ER to mitochondria. This family includes mammalian subunits EMC8 and EMC9, and Drosophila EMC8/9 homologue. EMC8 is also known...
Overlapping families in CDD: MPN superfamily, MPN_UPF0172

Members of UPF0172 whose function may be known:

UPF0181 (PF03701.14): Uncharacterised protein family (UPF0181) (50 a.a.), 8 papers
IPR005371: UPF0181. This family contains small proteins of about 50 amino acids of unknown function. The family includes YoaH.
Overlapping families in CDD: GlgP superfamily, PRK05114, more_P_ylases, yoaH

Members of UPF0181 whose function may be known:

DUF374 (PF04028.13): Domain of unknown function (DUF374) (69 a.a.), 8 papers
IPR007172: DUF374. This is a bacterial domain of unknown function.
Overlapping families in CDD: COG2121, LPLAT superfamily, LPLAT_DUF374-like

Members of DUF374 whose function may be known:

DUF412 (PF04217.13): Protein of unknown function, DUF412 (141 a.a.), 8 papers
IPR007334: UPF0208. This family consists of bacterial uncharacterised proteins.
Overlapping families in CDD: PRK01816, YfbV

Members of DUF412 whose function may be known:

DUF421 (PF04239.12): Protein of unknown function (DUF421) (108 a.a.), 8 papers
IPR007353: DUF421. This family of uncharacterised proteins is known as YDFR family
Overlapping families in CDD: YcaP

Members of DUF421 whose function may be known:

DUF423 (PF04241.15): Protein of unknown function (DUF423) (88 a.a.), 8 papers
IPR006696: DUF423. This is a potential integral membrane protein with no known function.
Overlapping families in CDD: PRK10873, YgdD

Members of DUF423 whose function may be known:

DUF446 (PF04287.12): tRNA pseudouridine synthase C (98 a.a.), 8 papers
IPR023376: YqcC-like_dom. This entry represents the structural domain found in the N-terminal of some tRNA pseudouridine synthase C proteins, as well as other uncharacterised proteins.
Overlapping families in CDD: YqcC

Members of DUF446 whose function may be known:

DUF452 (PF04301.13): Protein of unknown function (DUF452) (213 a.a.), 8 papers
IPR007398: DUF452. This is a family of uncharacterised proteins.
Overlapping families in CDD: COG2830

Members of DUF452 whose function may be known:

DUF489 (PF04356.12): Protein of unknown function (DUF489) (192 a.a.), 8 papers
IPR007451: HflD. When bacteriophage lambda infects to the Escherichia coli cell, it undergoes either lytic growth or lysogenization. The lambda CII protein is a key determinant in the lysis-lysogeny decision. Escherichia coli HflD is a factor that may sequesters CII from the target promoters and recruits it to the membrane where the FtsH protease is localized.
Overlapping families in CDD: HflD, PRK00218

Members of DUF489 whose function may be known:

DUF632 (PF04782.12): Protein of unknown function (DUF632) (310 a.a.), 8 papers
IPR006867: DUF632. This conserved region contains a leucine zipper-like domain. The proteins are found only in plants and their functions are unknown.
Overlapping families in CDD: DUF630, DUF630 superfamily, PRK13729, PRK13729 superfamily

Members of DUF632 whose function may be known:

DUF630 (PF04783.12): Protein of unknown function (DUF630) (59 a.a.), 8 papers
IPR006868: DUF630. This region is sometimes found at the N terminus of putative plant bZIP proteins . The function of this conserved region is not known.
Overlapping families in CDD: DUF632, DUF632 superfamily, PRK13729, PRK13729 superfamily

Members of DUF630 whose function may be known:

DUF808 (PF05661.12): Protein of unknown function (DUF808) (304 a.a.), 8 papers
IPR008526: YedI. This family of proteins includes inner membrane protein YedI.
Overlapping families in CDD: MutK, PRK10062

Members of DUF808 whose function may be known:

DUF1376 (PF07120.11): Protein of unknown function (DUF1376) (87 a.a.), 8 papers
IPR010781: DUF1376. This entry includes Bacteriophage PBC5 (Sinorhizobium phage PBC5), Orf49. The characteristics of the protein distribution suggest prophage matches in addition to the phage matches. This family consists of several hypothetical bacterial proteins of around 95 residues in length. The function of this family is unknown.
Overlapping families in CDD: PRK02854, PhdYeFM_antitox superfamily, YdaU

Members of DUF1376 whose function may be known:

DUF1387 (PF07139.11): Protein of unknown function (DUF1387) (312 a.a.), 8 papers
IPR009816: DUF1387. This family represents a conserved region approximately 300 residues long within a number of hypothetical proteins of unknown function that seem to be restricted to mammals.
Overlapping families in CDD: SMC_N superfamily, SMC_prok_A

Members of DUF1387 whose function may be known:

DUF1391 (PF07151.12): Protein of unknown function (DUF1391) (48 a.a.), 8 papers
IPR009821: DUF1391. This family consists of several Enterobacterial proteins of around 50 residues in length. Members of this family are found in Escherichia coli and Salmonella typhi where they are often known as YdfA. The function of this family is unknown.

Members of DUF1391 whose function may be known:

DUF1508 (PF07411.12): Domain of unknown function (DUF1508) (48 a.a.), 8 papers
IPR010879: DUF1508. This is a uncharacterised domain. This domain are often found as tandem repeats and in some cases represent the whole protein. It can also be found in the C-terminal region of a putative tryptophan--tRNA ligase.
Overlapping families in CDD: YegP

Members of DUF1508 whose function may be known:

DUF1615 (PF07759.12): Protein of unknown function (DUF1615) (320 a.a.), 8 papers
IPR011673: DUF1615. This is a family of proteins of unknown function expressed by various bacterial species. Some members of this family (e.g. , ) are thought to be lipoproteins. Another member of this family is thought to be involved in photosynthesis.

Members of DUF1615 whose function may be known:

DUF1749 (PF08538.10): Protein of unknown function (DUF1749) (299 a.a.), 8 papers
IPR013744: SidJ. This entry includes fusarinine C esterase SidJ from the yeast Neosartorya fumigata . Fusarinine C is an intracellular siderophore (an iron-chelating compound that transports iron across membranes) that is crucial for virulence. The closely related siderophore triacetylfusarinine C is not hydrolysed by SidJ. Homologues of SidJ are found in plants and bacteria.
Overlapping families in CDD: Abhydrolase superfamily

Members of DUF1749 whose function may be known:

DUF1773 (PF08593.10): Domain of unknown function (58 a.a.), 8 papers
IPR013902: DUF1773. This entry represents a conserved domain found in certain meiotically up-regulated gene products (MUG) from fungi. The actual function is not yet known. The proteins are likely to be cell-surface glycoproteins and may be situated close to telomeres, hence their being expressed during meiosis.
Overlapping families in CDD: DDRGK, DDRGK superfamily, DUF3552 superfamily, Neuromodulin_N superfamily, PTZ00121, RNase_Y, SMC_N superfamily, SMC_prok_B

Members of DUF1773 whose function may be known:

DUF1869 (PF08956.10): Domain of unknown function (DUF1869) (59 a.a.), 8 papers
IPR015051: YoaG. This entry represents a group of uncharacterised bacterial proteins.

Members of DUF1869 whose function may be known:

DUF2058 (PF09831.9): Uncharacterized protein conserved in bacteria (DUF2058) (174 a.a.), 8 papers
IPR018636: DUF2058. This family, found in various prokaryotic proteins, has no known function.
Overlapping families in CDD: Neuromodulin_N superfamily, PTZ00121, YaiL

Members of DUF2058 whose function may be known:

DUF2170 (PF09938.9): Uncharacterized protein conserved in bacteria (DUF2170) (137 a.a.), 8 papers
IPR019231: DUF2170. This family of various hypothetical prokaryotic proteins has no known function.
Overlapping families in CDD: YjfI

Members of DUF2170 whose function may be known:

DUF2207 (PF09972.9): Predicted membrane protein (DUF2207) (492 a.a.), 8 papers
IPR018702: DUF2207_membrane. This domain has no known function.

Members of DUF2207 whose function may be known:

DUF2367 (PF10164.9): Uncharacterized conserved protein (DUF2367) (104 a.a.), 8 papers
IPR019317: Brain_I3. This is a highly conserved set of proteins which contains three pairs of cysteine residues within a length of 42 amino acids and is rich in proline residues towards the N terminus. It includes a membrane protein that has been found to be highly expressed in the mouse brain and consequently, several members have been assigned as brain protein...

Members of DUF2367 whose function may be known:

DUF2465 (PF10239.9): Protein of unknown function (DUF2465) (323 a.a.), 8 papers
IPR018797: FAM98. FAM98A, B and C are glycine-rich proteins found from worms to humans. FAM98A contains a tubulin-binding calponin homology domain. It interacts with PLEKHM1 and functions in lysosome positioning in osteoclasts. FAM98A and FAM98B are included in a novel complex with DDX1 and C14orf166 and are involved in colorectal cancer progression.

Members of DUF2465 whose function may be known:

DUF2464 (PF10240.9): Multivesicular body subunit 12 (258 a.a.), 8 papers
IPR018798: MVB12A/B. MVB12A (also known as CFBP) and MVB12B are subunits of the ESCRT-I complex, which mediates the sorting of ubiquitinated cargo protein from the plasma membrane to the endosomal vesicle. MVB12A plays a key role in the ligand-mediated internalization and down-regulation of the EGF receptor.

Members of DUF2464 whose function may be known:

UPF0556 (PF10572.9): Uncharacterised protein family UPF0556 (153 a.a.), 8 papers
IPR018887: MYDGF. The function of myeloid-derived growth factor is to protect and repair the heart after myocardial infarction.

Members of UPF0556 whose function may be known:

DUF2776 (PF10951.8): Protein of unknown function (DUF2776) (348 a.a.), 8 papers
IPR021240: DUF2776. This bacterial family of proteins has no known function.

Members of DUF2776 whose function may be known:

DUF2544 (PF11245.8): Protein of unknown function (DUF2544) (246 a.a.), 8 papers
IPR021407: DUF2544. This is a bacterial family of proteins with unknown function.

Members of DUF2544 whose function may be known:

DUF3053 (PF11254.8): Protein of unknown function (DUF3053) (220 a.a.), 8 papers
IPR021413: DUF3053. Some members in this family of proteins are annotated as the membrane protein YiaF. No function is currently known.

Members of DUF3053 whose function may be known:

DUF3310 (PF11753.8): Protein of unknwon function (DUF3310) (60 a.a.), 8 papers
IPR021739: SaV-like. This entry includes bacteriophage T7, Gp1.7, which is a nucleotide kinase that catalyzes the phosphorylation of dGMP and dTMP to dGDP and dTDP. It also includes SaV from Lactococcus phage p2, which is involved in sensitivity to the host abortive infection mechanism AbiV. The characteristics of the protein distribution suggest prophage matches in addition to the phage matches.

Members of DUF3310 whose function may be known:

DUF3328 (PF11807.8): Domain of unknown function (DUF3328) (220 a.a.), 8 papers
IPR021765: UstYa-like. Oxidase ustYa is involved in the the production of ustiloxins, toxic cyclic peptides, in fungi. Ustiloxins were found to be the first example of cyclic peptidyl secondary metabolites that are ribosomally synthesized in filamentous fungi. The homologous genes ustYa and ustYb (which are found in the gene cluster for ustiloxins) have been shown to be involved in cyclization of...

Members of DUF3328 whose function may be known:

DUF3605 (PF12239.8): Protein of unknown function (DUF3605) (153 a.a.), 8 papers
IPR022036: DUF3605. This family of proteins is found mostly in fungi, including N-acetylglucosamine-induced protein 1 (Gig1) from Candida albicans. Gig1 plays a role in the N-acetylglucosamine metabolic pathway.

Members of DUF3605 whose function may be known:

DUF3677 (PF12432.8): Protein of unknown function (DUF3677) (82 a.a.), 8 papers
IPR022145: DUF3677. This domain of unknown function is found in metazoan proteins. It is found in the subunit 1 of the Integrator complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing.

Members of DUF3677 whose function may be known:

DUF3689 (PF12463.8): Protein of unknown function (DUF3689) (311 a.a.), 8 papers
IPR022162: TRPC4AP. TRPC4AP is a substrate-specific adapter of a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex required for cell cycle control.

Members of DUF3689 whose function may be known:

DUF3736 (PF12540.8): Protein of unknown function (DUF3736) (135 a.a.), 8 papers
IPR022207: GSE-like. This domain is found in genetic suppressor element coiled-coil proteins.
Overlapping families in CDD: BST2, BST2 superfamily

Members of DUF3736 whose function may be known:

DUF4043 (PF13252.6): Protein of unknown function (DUF4043) (353 a.a.), 8 papers
IPR025267: DUF4043. This family of proteins is functionally uncharacterised. There is a single completely conserved residue G that may be functionally important. Proteins in this entry include major structural protein ORF14 from Helicobacter pylori bacteriophage KHP30 and ORF017 from Pseudomonas phage KPP25.
Overlapping families in CDD: P22_CoatProtein superfamily, capsid_maj_N4

Members of DUF4043 whose function may be known:

DUF4205 (PF13898.6): Domain of unknown function (DUF4205) (347 a.a.), 8 papers
IPR025257: DUF4205. The function of this domain is not known.

Members of DUF4205 whose function may be known:

DUF4422 (PF14393.6): Domain of unknown function (DUF4422) (229 a.a.), 8 papers
IPR025536: DUF4422. The function of this domain is not known.

Members of DUF4422 whose function may be known:

DUF4731 (PF15875.5): Domain of unknown function (DUF4731) (75 a.a.), 8 papers
IPR031744: SMIM1. SMIM1 is a small integral membrane protein that regulates red blood cell formation. The Vel blood group antigen is expressed on the red blood cells of most individuals. SMIM1 has been shown to encode the Vel blood group antigen.

Members of DUF4731 whose function may be known:

DUF111 (PF01969.17): Protein of unknown function DUF111 (373 a.a.), 7 papers
IPR002822: Ni_insertion. Members of this family may be involved in the activation of nickel-pincer cofactor-dependent enzymes. LarC from Lactobacillus plantarum is involved, together with LarB and LarE, in the synthesis of the enzyme-bound cofactor of lactate racemase (LarA). Larc C binds Ni2+, and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor.
Overlapping families in CDD: COG1641, PRK04194, TIGR00299

Members of DUF111 whose function may be known:

UPF0167 (PF03691.14): Uncharacterised protein family (UPF0167) (173 a.a.), 7 papers
IPR005363: UPF0167. The proteins in this family are about 200 amino acids long and each contain 3 CXXC motifs.
Overlapping families in CDD: CbrC

Members of UPF0167 whose function may be known:

DUF383 (PF04063.14): Domain of unknown function (DUF383) (190 a.a.), 7 papers
IPR007205: Protein_HGH1_N. This entry represents a domain within Protein HGH1, of unknown function. It is found N-terminal to another domain of unknown function.
Overlapping families in CDD: DUF384, DUF384 superfamily

Members of DUF383 whose function may be known:

DUF416 (PF04222.12): Protein of unknown function (DUF416) (188 a.a.), 7 papers
IPR007338: DUF416. This is a bacterial family of uncharacterised proteins.
Overlapping families in CDD: YjaG

Members of DUF416 whose function may be known:

DUF441 (PF04284.13): Protein of unknown function (DUF441) (139 a.a.), 7 papers
IPR007382: UPF0756_TM. This entry contains proteins of unknown function. They are predicted to be transmembrane proteins with 4 TM domains.
Overlapping families in CDD: YeaL

Members of DUF441 whose function may be known:

DUF484 (PF04340.12): Protein of unknown function, DUF484 (225 a.a.), 7 papers
IPR007435: DUF484. This family consists of several proteins of uncharacterised function.
Overlapping families in CDD: GAF superfamily, PRK10963, YigA

Members of DUF484 whose function may be known:

DUF937 (PF06078.11): Bacterial protein of unknown function (DUF937) (137 a.a.), 7 papers
IPR009282: DUF937. This entry consists of several hypothetical bacterial proteins of unknown function.
Overlapping families in CDD: PRK11426, YidB

Members of DUF937 whose function may be known:

DUF1131 (PF06572.12): Protein of unknown function (DUF1131) (170 a.a.), 7 papers
IPR010938: DUF1131. This entry consists of several hypothetical bacterial proteins of unknown function.
Overlapping families in CDD: PRK10718

Members of DUF1131 whose function may be known:

DUF1176 (PF06674.11): Protein of unknown function (DUF1176) (328 a.a.), 7 papers
IPR009560: DUF1176. This family consists of several hypothetical bacterial proteins of around 340 residues in length. Members of this family contain six highly conserved cysteine residues. The function of this family is unknown.

Members of DUF1176 whose function may be known:

UPF0257 (PF06788.13): Uncharacterised protein family (UPF0257) (236 a.a.), 7 papers
IPR010646: UPF0257. This is a group of proteins of unknown function.
Overlapping families in CDD: PRK02939

Members of UPF0257 whose function may be known:

DUF1488 (PF07369.11): Protein of unknown function (DUF1488) (82 a.a.), 7 papers
IPR009962: DUF1488. This family consists of several hypothetical bacterial proteins of around 85 residues in length. The function of this family is unknown.

Members of DUF1488 whose function may be known:

DUF1496 (PF07383.12): Protein of unknown function (DUF1496) (53 a.a.), 7 papers
IPR009971: DUF1496. This family consists of several bacterial proteins of around 90 residues in length. Members of this family seem to be found exclusively in the Orders Vibrionales and Enterobacteriales. The function of this family is unknown.

Members of DUF1496 whose function may be known:

DUF1682 (PF07946.14): Protein of unknown function (DUF1682) (323 a.a.), 7 papers
IPR012879: DUF1682. The members of this family are all hypothetical eukaryotic proteins of unknown function. One member is described as being an adipocyte-specific protein, but no evidence of this was found.
Overlapping families in CDD: PTZ00399, tRNA-synt_1e superfamily

Members of DUF1682 whose function may be known:

DUF1691 (PF07950.11): Protein of unknown function (DUF1691) (107 a.a.), 7 papers
IPR012472: DUF1691. This family of fungal proteins is uncharacterised. Each protein contains two copies of this region.

Members of DUF1691 whose function may be known:

DUF1687 (PF07955.11): Protein of unknown function (DUF1687) (128 a.a.), 7 papers
IPR012882: Fmp46. This entry includes a group of putative redox proteins from fungi, including Fmp46 from yeasts.

Members of DUF1687 whose function may be known:

DUF1746 (PF08508.10): Fungal domain of unknown function (DUF1746) (115 a.a.), 7 papers
IPR013715: DUF1746. This is a fungal domain of unknown function. This domain can be found in DSC E3 ubiquitin ligase complex subunit 4 (Dsc4) from S. pombe. It is a component of the DSC E3 ubiquitin ligase complex required for the sre1 transcriptional activator proteolytic cleavage to release the soluble transcription factor from the membrane in low oxygen or sterol conditions....

Members of DUF1746 whose function may be known:

DUF1834 (PF08873.11): Domain of unknown function (DUF1834) (204 a.a.), 7 papers
IPR014972: Phage_Mu_Gp37. This entry is represented by Bacteriophage Mu, Gp37. The characteristics of the protein distribution suggest prophage matches in addition to the phage matches. This group of proteins are functionally uncharacterised. One member is the Gp37 protein from the FluMu prophage.
Overlapping families in CDD: COG5003

Members of DUF1834 whose function may be known:

DUF1837 (PF08878.11): Domain of unknown function (DUF1837) (231 a.a.), 7 papers
IPR014976: DUF1837. This group of proteins are functionally uncharacterised.
Overlapping families in CDD: DUF4297, DUF4297 superfamily

Members of DUF1837 whose function may be known:

DUF2138 (PF09909.9): Uncharacterized protein conserved in bacteria (DUF2138) (552 a.a.), 7 papers
IPR018671: DUF2138. This family of conserved hypothetical proteins has no known function.
Overlapping families in CDD: PRK11410, YfaA

Members of DUF2138 whose function may be known:

DUF2369 (PF10179.9): Uncharacterised conserved protein (DUF2369) (95 a.a.), 7 papers
IPR019326: DUF2369. This is a proline-rich region of a group of proteins found from plants to fungi. The function is largely unknown, although the entry contains Fibronectin type-III domain-containing protein C4orf31, which promotes matrix assembly and cell adhesiveness.

Members of DUF2369 whose function may be known: