Other Characterized Proteins Similar to aceA

Finding the characterized proteins for aceA (isocitrate lyase) in glycine biosynthesis

Or see clustering for step aceA

Or see all steps for glycine biosynthesis

Or cluster curated proteins matching a keyword

Definition of aceA

• Curated proteins or TIGRFams with EC 4.1.3.1
• Curated sequence CH_123497: Isocitrate lyase
• Ignore hits to Q05957 when looking for 'other' hits (isocitrate lyase (EC 4.1.3.1). Petal death protein; (R)-2-methylmalate lyase; D-citramalate lyase; Oxalacetic hydrolase; PSR132; EC 3.7.1.1; EC 4.1.3.-)
• Ignore hits to P28467 when looking for 'other' hits (Isocitrate lyase; ICL; Isocitrase; Isocitratase; EC 4.1.3.1. isocitrate lyase; EC 4.1.3.1)
• Comment: CH_123497 is isocitrate lyase but is annotated without the EC number. Q05957 is misannotated in BRENDA as this function; it prefers other substrates (PMID:16342929) P28467 is annotated as this by two resources but is only 15 amino acids, so it is ignored.

Fetched 41 sequences

Running ublast to find other characterized proteins with 40% identity and 70% coverage

Found hits to 0 other characterized sequences. (Found 41 hits including self hits.)

There are also 6 HMM-only high-coverage hits.

HMM-only sequences

(Since these sequences' annotations are outside the definition for aceA, HMM hits that are over 40% similar to these sequences will be scored as moderate confidence.)

ACEB_YEAST / Q12031 Mitochondrial 2-methylisocitrate lyase ICL2; Methylisocitrate lyase; EC 4.1.3.30 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
PFams: ICL
575 amino acids: PaperBLAST, CDD

GI|61657961 methylisocitrate lyase precursor; EC 4.1.3.30 from Emericella nidulans
CH_122270 methylisocitrate lyase; EC 4.1.3.30 from Emericella nidulans
PFams: ICL
604 amino acids: PaperBLAST, CDD

ACEB_EMENI / C8V9Y5 Methylisocitrate lyase, mitochondrial; 2-methylisocitrate lyase, mitochondrial; EC 4.1.3.30 from Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
PFams: ICL
610 amino acids: PaperBLAST, CDD

ACEB_YARLI / Q6BZP5 2-methylisocitrate lyase, mitochondrial; EC 4.1.3.30 from Yarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica)
PFams: ICL
565 amino acids: PaperBLAST, CDD

ACEB_SCHPO / Q9P6J1 Mitochondrial 2-methylisocitrate lyase; Methylisocitrate lyase; EC 4.1.3.30 from Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
PFams: ICL
518 amino acids: PaperBLAST, CDD

ACEB_HYPAI / G9NNY7 2-methylisocitrate lyase, mitochondrial; EC 4.1.3.30 from Hypocrea atroviridis (strain ATCC 20476 / IMI 206040) (Trichoderma atroviride)
PFams: ICL, PEP_mutase
561 amino acids: PaperBLAST, CDD