Other Characterized Proteins Similar to split_metE_2

Finding the characterized proteins for split_metE_2 (vitamin B12-independent methionine synthase, catalytic component) in L-methionine biosynthesis

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Definition of split_metE_2

• Predicted: UniProt sequence G0EFB7_PYRF1: RecName: Full=Methionine synthase {ECO:0000256|HAMAP-Rule:MF_00288}; EC=2.1.1.- {ECO:0000256|HAMAP-Rule:MF_00288}; AltName: Full=Homocysteine methyltransferase {ECO:0000256|HAMAP-Rule:MF_00288};
• Predicted: UniProt sequence D4GW90: RecName: Full=Methionine synthase {ECO:0000256|HAMAP-Rule:MF_00288}; EC=2.1.1.- {ECO:0000256|HAMAP-Rule:MF_00288}; AltName: Full=Homocysteine methyltransferase {ECO:0000256|HAMAP-Rule:MF_00288};
• Comment: In many thermophilic archaea, MetE seems to be split into two pieces (see PMC7857596). The catalytic component has the necessary zinc-binding residues (H219, C221, C307) and homocysteine-binding residues (S20, E71, D185). We added the gene from Haloferax volcanii (D4GW90) as it has the correct functional residues and is conserved next to a potential folate-binding component (D4GW90).

Fetched 2 sequences

Running ublast to find other characterized proteins with 40% identity and 70% coverage

Found hits to 0 other characterized sequences. (Found 0 hits including self hits.)