Clusters of Characterized Proteins

GapMind for catabolism of small carbon sources

Clusters of Characterized Proteins

Clustering the characterized proteins for hcl (4-hydroxybenzoyl-CoA ligase) in 4-hydroxybenzoate catabolism

Or see other characterized proteins similar to hcl

Or see all steps for 4-hydroxybenzoate catabolism

Or cluster curated proteins matching a keyword

Definition of hcl

Curated proteins or TIGRFams with EC 6.2.1.27
Curated sequence Q8GQN9: Benzoate--CoA ligase; Benzoyl-CoA synthetase; EC 6.2.1.25. benzoate-CoA ligase (EC 6.2.1.25). benzoate-CoA ligase (EC 6.2.1.32; EC 6.2.1.25)
Ignore hits to items matching 6.2.1.25 when looking for 'other' hits
Ignore hits to Q8VUF1 when looking for 'other' hits (benzoyl-CoA reductase (EC 1.3.7.8))
Comment: benzoyl-CoA ligases (EC 6.2.1.25) may have this activity as well, i.e. see PMID:12897012 (discussing Q8GQN9). Q8VUF1 (probably a benzoyl-CoA ligase) is misannotated in BRENDA as benzoyl-CoA reductase.

Fetched 4 sequences

Running BLASTp

Found similarities, at above 30% identity and 75% coverage, for 4 of these sequences

Found 1 clusters of similar sequences. Download as table or as draft rules or view by organism

Cluster 1 493-539 amino acids (not heteromeric)

The first sequence in each cluster is the seed.

Q5P0J2 4-hydroxybenzoate-CoA ligase (EC 6.2.1.27); 3-hydroxybenzoate-CoA ligase (EC 6.2.1.37) from Azoarcus sp.
PFams: AMP-binding
493 amino acids: PaperBLAST, CDD, Compare to cluster

Q53005 4-hydroxybenzoate-CoA ligase subunit (EC 6.2.1.25; EC 6.2.1.27) from Rhodopseudomonas palustris (strain ATCC BAA-98 / CGA009)
4HBCL_RHOPA / Q53005 4-hydroxybenzoate--CoA/benzoate--CoA ligase; 4-hydroxybenzoyl-CoA synthetase; EC 6.2.1.25; EC 6.2.1.27 from Rhodopseudomonas palustris (strain ATCC BAA-98 / CGA009)
PFams: AMP-binding, AMP-binding_C
539 amino acids: PaperBLAST, CDD, Compare to cluster

Q8GQN9 benzoate-CoA ligase (EC 6.2.1.32; EC 6.2.1.25) from Thauera aromatica
BCLA_THAAR / Q8GQN9 Benzoate--CoA ligase; Benzoyl-CoA synthetase; EC 6.2.1.25 from Thauera aromatica
Q8GQN9 benzoate-CoA ligase (EC 6.2.1.25) from Thauera aromatica
PFams: AMP-binding, AMP-binding_C
527 amino acids: PaperBLAST, CDD, Compare to cluster

Q9AJS8 4-hydroxybenzoate-CoA ligase (EC 6.2.1.27) from Thauera aromatica
3HBCL_THAAR / Q9AJS8 3-hydroxybenzoate--CoA/4-hydroxybenzoate--CoA ligase; 3-hydroxybenzoyl-CoA synthetase; EC 6.2.1.27; EC 6.2.1.37 from Thauera aromatica
Q9AJS8 4-hydroxybenzoate-CoA ligase (EC 6.2.1.27); 3-hydroxybenzoate-CoA ligase (EC 6.2.1.37) from Thauera aromatica
PFams: AMP-binding, AMP-binding_C
523 amino acids: PaperBLAST, CDD, Compare to cluster