Clusters of Characterized Proteins

Clustering the characterized proteins for lctP (L-lactate:H+ symporter LctP or LidP) in L-lactate catabolism

Or see other characterized proteins similar to lctP

Or see all steps for L-lactate catabolism

Or cluster curated proteins matching a keyword

Definition of lctP

• Curated sequence P33231: L-lactate permease. Lactate permease, LctP or LidP (substrates: L-lactate, D-lactate and glycolate). lactate/glycolate:H⁺ symporter LldP. lactate/glycolate:H⁺ symporter LldP. (R)-lactate / (S)-lactate / glycolate:H+ symporter LldP
• Curated sequence P71067: L-lactate permease. L-lactate permease
• Curated sequence AO356_07550: L-lactate and D-lactate permease (lctP family)
• Curated sequence Q46839: Glycolate permease, GlcA or YghK (substrates: L-lactate, D-lactate and glycolate). glycolate/lactate:H⁺ symporter GlcA. glycolate/lactate:H⁺ symporter GlcA
• Ignore hits to GFF4712 when looking for 'other' hits (D-lactate transporter (lctP family))
• UniProt sequence Q8EGS2: RecName: Full=L-lactate permease {ECO:0000256|RuleBase:RU365092};
• UniProt sequence L0GFN1: RecName: Full=L-lactate permease {ECO:0000256|RuleBase:RU365092};
• Curated sequence P71067: L-lactate permease. L-lactate permease
• Comment: E. coli GlcA (Q46839) is similar to LctP and is reported to transport both L- and D-lactate. PS417_24105 (GFF4172) is important only for D-lactate utilization but is closely related to AO356_07550 and could be an L-lactate transporter as well. SO_1522 (Q8EGS2) and Psest_0955 (L0GFN1) probably transport both isomers. Bacillus subtilis LutP (P71067) is an L-lactate transporter.

Fetched 6 sequences

Running BLASTp

Found similarities, at above 30% identity and 75% coverage, for 6 of these sequences

Found 2 clusters of similar sequences. Download as table or as draft rules or view by organism

Cluster 1 551-564 amino acids (not heteromeric)

b3603 (R)-lactate / (S)-lactate / glycolate:H+ symporter LldP from Escherichia coli BW25113
b3603 lactate/glycolate:H⁺ symporter LldP from Escherichia coli K-12 substr. MG1655
P33231 lactate/glycolate:H⁺ symporter LldP from Escherichia coli (strain K12)
LLDP_ECOLI / P33231 L-lactate permease from Escherichia coli (strain K12)
TC 2.A.14.1.1 / P33231 Lactate permease, LctP or LidP (substrates: L-lactate, D-lactate and glycolate) from Escherichia coli
PFams: Lactate_perm
551 amino acids: PaperBLAST, CDD, Compare to cluster

LUTP_BACSU / P71067 L-lactate permease from Bacillus subtilis (strain 168)
TC 2.A.14.1.3 / P71067 L-lactate permease from Bacillus subtilis (strain 168)
PFams: Lactate_perm
563 amino acids: PaperBLAST, CDD, Compare to cluster

b2975 glycolate/lactate:H⁺ symporter GlcA from Escherichia coli K-12 substr. MG1655
Q46839 glycolate/lactate:H⁺ symporter GlcA from Escherichia coli (strain K12)
TC 2.A.14.1.2 / Q46839 Glycolate permease, GlcA or YghK (substrates: L-lactate, D-lactate and glycolate) from Escherichia coli
PFams: Lactate_perm
560 amino acids: PaperBLAST, CDD, Compare to cluster

AO356_07550 L-lactate and D-lactate permease (lctP family) from Pseudomonas fluorescens FW300-N2C3
PFams: Lactate_perm
564 amino acids: PaperBLAST, CDD, Compare to cluster

Cluster 2 547-564 amino acids (not heteromeric)

L0GFN1 L-lactate permease {ECO:0000256|RuleBase:RU365092}
564 amino acids: PaperBLAST, CDD, Compare to cluster

Q8EGS2 L-lactate permease {ECO:0000256|RuleBase:RU365092}
547 amino acids: PaperBLAST, CDD, Compare to cluster