Clusters of Characterized Proteins

Clustering the characterized proteins for maeN (malate transporter maeN) in L-malate catabolism

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Definition of maeN

• Curated sequence O05256: Na(+)-malate symporter; Sodium-dependent malate transporter. Malate:Na+ symporter
• Curated sequence O07032: Malate:lactate antiporter (substrates include: S-lactate, R-lactate, S-malate and S-citramalate)
• Curated sequence P94363: L-malate/citrate:H+ symporter (electroneutral)
• Curated sequence Q53787: L-Malate permease
• Comment: This cluster seems to include both H+ and Na+ dependent malate transporters, as well as Lactococcus lactis mleP or maeP (O07032) which also exports lactate.

Fetched 4 sequences

Running BLASTp

Found similarities, at above 30% identity and 75% coverage, for 4 of these sequences

Found 1 clusters of similar sequences. Download as table or as draft rules or view by organism

Cluster 1 425-450 amino acids (not heteromeric)

MAEN_BACSU / O05256 Na(+)-malate symporter; Sodium-dependent malate transporter from Bacillus subtilis (strain 168)
TC 2.A.24.2.3 / O05256 Malate:Na+ symporter from Bacillus subtilis
PFams: 2HCT
448 amino acids: PaperBLAST, CDD, Compare to cluster

TC 2.A.24.2.2 / O07032 Malate:lactate antiporter (substrates include: S-lactate, R-lactate, S-malate and S-citramalate) from Lactococcus lactis (subsp. lactis) (Streptococcus lactis)
PFams: 2HCT
425 amino acids: PaperBLAST, CDD, Compare to cluster

TC 2.A.24.2.4 / P94363 L-malate/citrate:H+ symporter (electroneutral) from Bacillus subtilis
PFams: 2HCT
450 amino acids: PaperBLAST, CDD, Compare to cluster

TC 2.A.24.2.1 / Q53787 L-Malate permease from Streptococcus bovis
PFams: 2HCT
441 amino acids: PaperBLAST, CDD, Compare to cluster