Clusters of Characterized Proteins

Clustering the characterized proteins for nagEIIA (N-acetylglucosamine phosphotransferase system, EII-A component (PtsG/YpqE/GamP)) in N-acetyl-D-glucosamine catabolism

Or see other characterized proteins similar to nagEIIA

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Definition of nagEIIA

• Curated sequence P20166: PTS system glucose-specific EIICBA component; EC 2.7.1.-; EC 2.7.1.69. The glucose IICBA porter (PtsG) 44% identical to 4.A.1.1.1)
• UniProt sequence P50829: RecName: Full=Putative phosphotransferase enzyme IIA component YpqE; AltName: Full=Putative PTS system EIIA component;
• Curated sequence P39816: Putative PTS system glucosamine-specific EIICBA component; EC 2.7.1.193. The glucosamine IICBA porter (GamP) (40% identical to 4.A.1.1.2) (Plumbridge 2015). The IIA domain in this protein can transfer the phosphoryl moiety to the maltose, N-acetylglucosamine, sucrose and trehalose PTS systems (MalP, NagP, SacP and TreP, respectively)
• Comment: Bacillus subtilis has EII-CB, known as nagP. The major EII-A is ptsG (P20166, see PMID:30038046), which is a bit surprising as ptsG has EII-B and EII-C domains as well and is thought to be specific for glucose; YpqE (P50829) or GamP (P39816) also suffice. (YpqE has EII-A only, while GamP is the EII-CBA protein for glucosamine)

Fetched 3 sequences

Running BLASTp

Found similarities, at above 30% identity and 75% coverage, for 2 of these sequences

Found 1 clusters of similar sequences. Another 1 sequences are not clustered. Download as table or as draft rules or view by organism

Cluster 1 631-699 amino acids (not heteromeric)

TC 4.A.1.1.9 / P20166 The glucose IICBA porter (PtsG) 44% identical to 4.A.1.1.1) from Bacillus subtilis
GB|CAB13262.1 PTS system glucose-specific EIICBA component; EC 2.7.1.-; EC 2.7.1.69 from Bacillus subtilis
PFams: PTS_EIIC, PTS_EIIB, PTS_EIIA_1
699 amino acids: PaperBLAST, CDD, Compare to cluster

PTW3C_BACSU / P39816 Putative PTS system glucosamine-specific EIICBA component; EC 2.7.1.193 from Bacillus subtilis (strain 168)
TC 4.A.1.1.6 / P39816 The glucosamine IICBA porter (GamP) (40% identical to 4.A.1.1.2) (Plumbridge 2015). The IIA domain in this protein can transfer the phosphoryl moiety to the maltose, N-acetylglucosamine, sucrose and trehalose PTS systems (MalP, NagP, SacP and TreP, respectively) from Bacillus subtilis
PFams: PTS_EIIC, PTS_EIIB, PTS_EIIA_1
631 amino acids: PaperBLAST, CDD, Compare to cluster

Singletons (0/1 heteromeric)

P50829 Putative phosphotransferase enzyme IIA component YpqE; Putative PTS system EIIA component
168 amino acids: PaperBLAST, CDD