Clusters of Characterized Proteins

Clustering the characterized proteins for nagK (N-acetylglucosamine kinase) in N-acetyl-D-glucosamine catabolism

Or see other characterized proteins similar to nagK

Or see all steps for N-acetyl-D-glucosamine catabolism

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Definition of nagK

• Curated proteins or TIGRFams with EC 2.7.1.59
• Ignore hits to CH_123431 when looking for 'other' hits (N-acetylglucosamine kinase)
• UniProt sequence Q8P6S9: SubName: Full=Glucose kinase {ECO:0000313|EMBL:AAM42158.1};
• UniProt sequence Q8P6M4: SubName: Full=Glucose kinase {ECO:0000313|EMBL:AAM42215.1};
• Comment: Ignore a putative enzyme from C. albicans, not given this EC number in CharProtDB. PMC2832512 identified two NAG kinases in Xanthomonas campestris, XCC2886 (Q8P6S9) and XCC2943 (Q8P6M4)

Fetched 18 sequences

Running BLASTp

Found similarities, at above 30% identity and 75% coverage, for 14 of these sequences

Found 4 clusters of similar sequences. Another 4 sequences are not clustered. Download as table or as draft rules or view by organism

Cluster 1 294-302 amino acids (not heteromeric)

SO3507 N-acetylglucosamine kinase (EC 2.7.1.59) from Shewanella oneidensis MR-1
PFams: BcrAD_BadFG
300 amino acids: PaperBLAST, CDD, Compare to cluster

Shewana3_3114 N-acetylglucosamine kinase (EC 2.7.1.59) from Shewanella sp. ANA-3
PFams: BcrAD_BadFG
302 amino acids: PaperBLAST, CDD, Compare to cluster

Shew_1116 N-acetylglucosamine kinase (EC 2.7.1.59) from Shewanella loihica PV-4
PFams: BcrAD_BadFG
299 amino acids: PaperBLAST, CDD, Compare to cluster

PGA1_c27910 N-acetylglucosamine kinase (EC 2.7.1.59) from Phaeobacter inhibens BS107
PFams: BcrAD_BadFG
300 amino acids: PaperBLAST, CDD, Compare to cluster

Sama_0944 N-acetylglucosamine kinase (EC 2.7.1.59) from Shewanella amazonensis SB2B
PFams: BcrAD_BadFG
301 amino acids: PaperBLAST, CDD, Compare to cluster

SMc02875 N-acetylglucosamine kinase (EC 2.7.1.59) from Sinorhizobium meliloti 1021
PFams: BcrAD_BadFG
294 amino acids: PaperBLAST, CDD, Compare to cluster

Cluster 2 303-308 amino acids (not heteromeric)

b1119 N-acetyl-D-glucosamine kinase (EC 2.7.1.59) from Escherichia coli K-12 substr. MG1655
P75959 N-acetyl-D-glucosamine kinase (EC 2.7.1.59) from Escherichia coli (strain K12)
NAGK_ECOLI / P75959 N-acetyl-D-glucosamine kinase; GlcNAc kinase; EC 2.7.1.59 from Escherichia coli (strain K12)
GB|ABB62126.1 N-acetyl-D-glucosamine kinase; EC 2.7.1.59 from Escherichia coli K12
PFams: ROK, Glucokinase
303 amino acids: PaperBLAST, CDD, Compare to cluster

A0KYQ6 N-acetylgalactosamine kinase from Shewanella sp. (strain ANA-3)
AGAK_SHESA / A0KYQ6 N-acetylgalactosamine kinase AgaK; GalNAc kinase; N-acetylglucosamine kinase; GlcNAc kinase; EC 2.7.1.-; EC 2.7.1.59 from Shewanella sp. (strain ANA-3)
PFams: ROK, Glucokinase
308 amino acids: PaperBLAST, CDD, Compare to cluster

NAGK_SALTY / Q8ZPZ9 N-acetyl-D-glucosamine kinase; GlcNAc kinase; EC 2.7.1.59 from Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
PFams: ROK, Glucokinase
303 amino acids: PaperBLAST, CDD, Compare to cluster

Cluster 3 343-344 amino acids (not heteromeric)

NAGK_RAT / P81799 N-acetyl-D-glucosamine kinase; N-acetylglucosamine kinase; GlcNAc kinase; EC 2.7.1.59 from Rattus norvegicus (Rat)
PFams: BcrAD_BadFG
343 amino acids: PaperBLAST, CDD, Compare to cluster

NAGK_MOUSE / Q9QZ08 N-acetyl-D-glucosamine kinase; N-acetylglucosamine kinase; GlcNAc kinase; EC 2.7.1.59 from Mus musculus (Mouse)
Q9QZ08 N-acetylglucosamine kinase (EC 2.7.1.59) from Mus musculus
PFams: BcrAD_BadFG
343 amino acids: PaperBLAST, CDD, Compare to cluster

NAGK_HUMAN / Q9UJ70 N-acetyl-D-glucosamine kinase; N-acetylglucosamine kinase; GlcNAc kinase; EC 2.7.1.59 from Homo sapiens (Human)
Q9UJ70 N-acetylglucosamine kinase (EC 2.7.1.59) from Homo sapiens
PFams: BcrAD_BadFG
344 amino acids: PaperBLAST, CDD, Compare to cluster

Cluster 4 338-344 amino acids (not heteromeric)

Q8P6M4 Glucose kinase
344 amino acids: PaperBLAST, CDD, Compare to cluster

Q8P6S9 Glucose kinase
338 amino acids: PaperBLAST, CDD, Compare to cluster

Singletons (0/4 heteromeric)

HXK1_CANAL / Q59RW5 N-acetylglucosamine kinase 1; GlcNAc kinase 1; Hexokinase 1; EC 2.7.1.59; EC 2.7.1.1 from Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
PFams: Hexokinase_1, Hexokinase_2
493 amino acids: PaperBLAST, CDD

MURK_CLOAB / Q97ML3 N-acetylmuramic acid/N-acetylglucosamine kinase; MurNAc/GlcNAc kinase; Murein sugar kinase; EC 2.7.1.-; EC 2.7.1.59 from Clostridium acetobutylicum (strain ATCC 824 / DSM 792 / JCM 1419 / LMG 5710 / VKM B-1787)
PFams: BcrAD_BadFG
306 amino acids: PaperBLAST, CDD

Q5GBH5 N-acetylglucosamine kinase (EC 2.7.1.59) from Bacteroides fragilis
PFams: ROK
326 amino acids: PaperBLAST, CDD

CA265_RS11300 N-acetylglucosamine kinase (EC 2.7.1.59) from Pedobacter sp. GW460-11-11-14-LB5
PFams: ROK
313 amino acids: PaperBLAST, CDD