Clusters of Characterized Proteins

GapMind for Amino acid biosynthesis

Clusters of Characterized Proteins

Clustering the characterized proteins for argB (N-acylglutamate kinase) in L-arginine biosynthesis

Or see other characterized proteins similar to argB

Or see all steps for L-arginine biosynthesis

Or cluster curated proteins matching a keyword

Definition of argB

Curated proteins or TIGRFams with EC 2.7.2.8
Curated proteins matching N-succinylglutamate kinase
Ignore hits to O67848 when looking for 'other' hits (UDP-3-O-acyl-N-acetylglucosamine deacetylase (EC 3.5.1.108))
Ignore hits to Q87EL2 when looking for 'other' hits (amino-acid N-acetyltransferase (EC 2.3.1.1))
Curated sequence CH_123299: arginine biosynthetic enzyme activities
Comment: ArgB includes Bacteroides proteins that act on N-succinylglutamate instead of the usual N-acetylglutamate (i.e. BT3395). See "Discovery of novel pathways of microbial arginine biosynthesis" (2010), PhD thesis of Juan Manuel Cabrera Luque, which shows that argB from B. fragilis is N-succinylglutamate kinase. O67848 in BRENDA seems likely to be argB but is misannotated as a deacetylase; also, Q87EL2 is likely to be argB as well as argA. CH_123299 has a broader annotation but probably has this activity.

Fetched 21 sequences

Running BLASTp

Found similarities, at above 30% identity and 75% coverage, for 21 of these sequences

Found 3 clusters of similar sequences. Download as table or as draft rules or view by organism

Cluster 1 248-347 amino acids (not heteromeric)

ARGB_THEMA / Q9X2A4 Acetylglutamate kinase; N-acetyl-L-glutamate 5-phosphotransferase; NAG kinase; NAGK; EC 2.7.2.8 from Thermotoga maritima (strain ATCC 43589 / DSM 3109 / JCM 10099 / NBRC 100826 / MSB8)
Q9X2A4 acetylglutamate kinase (EC 2.7.2.8) from Thermotoga maritima
PFams: AA_kinase
282 amino acids: PaperBLAST, CDD, Compare to cluster

b3959 acetylglutamate kinase (EC 2.7.2.8) from Escherichia coli K-12 substr. MG1655
P0A6C8 acetylglutamate kinase (EC 2.7.2.8) from Escherichia coli (strain K12)
ARGB_ECOLI / P0A6C8 Acetylglutamate kinase; N-acetyl-L-glutamate 5-phosphotransferase; NAG kinase; NAGK; EC 2.7.2.8 from Escherichia coli (strain K12)
A0A140NEG9 acetylglutamate kinase (EC 2.7.2.8) from Escherichia coli
SP|P0A6C8 acetylglutamate kinase; EC 2.7.2.8 from Escherichia coli
PFams: AA_kinase
258 amino acids: PaperBLAST, CDD, Compare to cluster

A0A1D6E3W6 acetylglutamate kinase (EC 2.7.2.8) from Zea mays
PFams: AA_kinase
345 amino acids: PaperBLAST, CDD, Compare to cluster

Q4JAQ2 [LysW}-glutamate/[LysW]-aminoadipate kinase (EC 2.7.2.17; EC 2.7.2.19) (from HMM only) from Sulfolobus acidocaldarius (strain ATCC 33909 / DSM 639 / JCM 8929 / NBRC 15157 / NCIMB 11770)
LYSZ_SULAC / Q4JAQ2 [LysW]-aminoadipate/[LysW]-glutamate kinase; EC 2.7.2.17; EC 2.7.2.19 from Sulfolobus acidocaldarius (strain ATCC 33909 / DSM 639 / JCM 8929 / NBRC 15157 / NCIMB 11770)
Q4JAQ2 [amino group carrier protein]-L-2-aminoadipate 6-kinase (EC 2.7.2.17) from Sulfolobus acidocaldarius
PFams: AA_kinase
261 amino acids: PaperBLAST, CDD, Compare to cluster

Q59281 acetylglutamate kinase (EC 2.7.2.8) from Corynebacterium glutamicum
PFams: AA_kinase
294 amino acids: PaperBLAST, CDD, Compare to cluster

Q6R6P5 acetylglutamate kinase (EC 2.7.2.8) from Corynebacterium crenatum
PFams: AA_kinase
317 amino acids: PaperBLAST, CDD, Compare to cluster

Q6V1L5 acetylglutamate kinase (EC 2.7.2.8) from Synechococcus elongatus
PFams: AA_kinase
301 amino acids: PaperBLAST, CDD, Compare to cluster

ARGB_PSEAE / Q9HTN2 Acetylglutamate kinase; N-acetyl-L-glutamate 5-phosphotransferase; NAG kinase; NAGK; EC 2.7.2.8 from Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
Q9HTN2 acetylglutamate kinase (EC 2.7.2.8) from Pseudomonas aeruginosa
PFams: AA_kinase
301 amino acids: PaperBLAST, CDD, Compare to cluster

NAGK_ARATH / Q9SCL7 Acetylglutamate kinase, chloroplastic; N-acetyl-L-glutamate 5-phosphotransferase; NAG kinase; AtNAGK; EC 2.7.2.8 from Arabidopsis thaliana (Mouse-ear cress)
Q9SCL7 acetylglutamate kinase (EC 2.7.2.8) from Arabidopsis thaliana
PFams: AA_kinase
347 amino acids: PaperBLAST, CDD, Compare to cluster

LYSZ_THET2 / O50147 [LysW]-aminoadipate kinase; EC 2.7.2.17 (from HMM only) from Thermus thermophilus (strain ATCC BAA-163 / DSM 7039 / HB27)
PFams: AA_kinase
269 amino acids: PaperBLAST, CDD, Compare to cluster

ARGB_MYCTU / P9WQ01 Acetylglutamate kinase; N-acetyl-L-glutamate 5-phosphotransferase; NAG kinase; NAGK; EC 2.7.2.8 from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
PFams: AA_kinase
294 amino acids: PaperBLAST, CDD, Compare to cluster

ARGB_THET2 / Q72HA9 Acetylglutamate kinase; N-acetyl-L-glutamate 5-phosphotransferase; NAG kinase; NAGK; EC 2.7.2.8 from Thermus thermophilus (strain ATCC BAA-163 / DSM 7039 / HB27)
PFams: AA_kinase
248 amino acids: PaperBLAST, CDD, Compare to cluster

Q5SH27 [LysW]-L-2-aminoadipate 6-kinase monomer (EC 2.7.2.17) (from HMM only) from Thermus thermophilus (strain ATCC 27634 / DSM 579 / HB8)
PFams: AA_kinase
269 amino acids: PaperBLAST, CDD, Compare to cluster

BT3395 N-succinylglutamate kinase (EC 2.7.2.-) from Bacteroides thetaiotaomicron VPI-5482
PFams: AA_kinase
257 amino acids: PaperBLAST, CDD, Compare to cluster

Cluster 2 426-447 amino acids (not heteromeric)

A0A0H2X8L7 acetylglutamate kinase (EC 2.7.2.8) from Xanthomonas campestris
PFams: AA_kinase, NAT
447 amino acids: PaperBLAST, CDD, Compare to cluster

Q0ASS9 amino-acid N-acetyltransferase (EC 2.3.1.1); acetylglutamate kinase (EC 2.7.2.8) from Maricaulis maris
PFams: AA_kinase, NAT, Acetyltransf_1
441 amino acids: PaperBLAST, CDD, Compare to cluster

Q8P8J6 acetylglutamate kinase (EC 2.7.2.8) from Xanthomonas campestris
PFams: AA_kinase, NAT
426 amino acids: PaperBLAST, CDD, Compare to cluster

N515DRAFT_3768 N-acetylglutamate synthase; N-acetylglutamate kinase (EC 2.3.1.1; EC 2.7.2.8) from Dyella japonica UNC79MFTsu3.2
PFams: AA_kinase, NAT
438 amino acids: PaperBLAST, CDD, Compare to cluster

Cluster 3 857-885 amino acids (not heteromeric)

ARG56_YEAST / Q01217 Protein ARG5,6, mitochondrial; EC 1.2.1.38; EC 2.7.2.8 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Q01217 acetylglutamate kinase (EC 2.7.2.8) from Saccharomyces cerevisiae
PFams: AA_kinase, NAT, Semialdhyde_dh, Semialdhyde_dhC
863 amino acids: PaperBLAST, CDD, Compare to cluster

CH_123299 arginine biosynthetic enzyme activities from Candida albicans
PFams: AA_kinase, NAT, Semialdhyde_dh
857 amino acids: PaperBLAST, CDD, Compare to cluster

ARG56_SCHPO / P31318 Protein arg11, mitochondrial; EC 1.2.1.38; EC 2.7.2.8 from Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
GI|1204210 N-acetyl-gamma-glutamyl-phosphate reductase/acetylglutamate kinase; EC 1.2.1.38; EC 2.7.2.8 from Schizosaccharomyces pombe
PFams: AA_kinase, NAT, Semialdhyde_dh
885 amino acids: PaperBLAST, CDD, Compare to cluster