Clusters of Characterized Proteins

Clustering the characterized proteins for argE (N-acetylornithine deacetylase) in L-arginine biosynthesis

Or see other characterized proteins similar to argE

Or see all steps for L-arginine biosynthesis

Or cluster curated proteins matching a keyword

Definition of argE

• Curated proteins or TIGRFams with EC 3.5.1.16
• Curated proteins matching N-acetylcitrulline deacetylase
• Predicted: UniProt sequence W3Y6L2: SubName: Full=Amidohydrolase {ECO:0000313|EMBL:ETS93161.1};
• Comment: This EC number also includes N-acetylcitrulline deacetylase, which is part of pathway III. A putative amidohydrolase "ArgA3" (W3Y6L2) is in a conserved operon with ornithine carbamoyltransferase (the next step) in Veillonella and related genera (PMC9026213). The genome context includes other arginine synthesis genes as well. Although ArgA3 was proposed to be a N-acetylglutamate synthase, it is related to N-acetyl-cysteine deacetylase, and the genomes with "ArgA3" are lacking argE as well; so we think argE is the more likely function.

Fetched 8 sequences

Running BLASTp

Found similarities, at above 30% identity and 75% coverage, for 6 of these sequences

Found 2 clusters of similar sequences. Another 3 sequences are not clustered. Download as table or as draft rules or view by organism

Cluster 1 366-374 amino acids (not heteromeric)

N515DRAFT_3767 N-acetylcitrulline deacetylase (EC 3.5.1.-) from Dyella japonica UNC79MFTsu3.2
PFams: Peptidase_M20, M20_dimer
366 amino acids: PaperBLAST, CDD, Compare to cluster

Q92Y75 acetylornithine deacetylase (EC 3.5.1.16) from Sinorhizobium meliloti
PFams: Peptidase_M20, M20_dimer
374 amino acids: PaperBLAST, CDD, Compare to cluster

Q8P8J5 acetylcitrulline deacetylase subunit (EC 3.5.1.16) from Xanthomonas campestris pv. campestris (strain ATCC 33913 / DSM 3586 / NCPPB 528 / LMG 568 / P 25)
ACDAS_XANCP / Q8P8J5 N-acetyl-L-citrulline deacetylase; ACDase; Acetylcitrulline deacetylase; EC 3.5.1.- from Xanthomonas campestris pv. campestris (strain ATCC 33913 / DSM 3586 / NCPPB 528 / LMG 568 / P 25)
PFams: Peptidase_M20, M20_dimer
366 amino acids: PaperBLAST, CDD, Compare to cluster

Cluster 2 440-447 amino acids (not heteromeric)

Q9C5C4 acetylornithine deacetylase (EC 3.5.1.16) from Arabidopsis thaliana
PFams: Peptidase_M20, M20_dimer
440 amino acids: PaperBLAST, CDD, Compare to cluster

ARGE_DICDI / P54638 Acetylornithine deacetylase; N-acetylornithinase; AO; Acetylornithinase; NAO; EC 3.5.1.16 from Dictyostelium discoideum (Social amoeba)
PFams: Peptidase_M20, M20_dimer
447 amino acids: PaperBLAST, CDD, Compare to cluster

Singletons (0/3 heteromeric)

b3957 acetylornithine deacetylase (EC 3.5.1.16) from Escherichia coli K-12 substr. MG1655
P23908 acetylornithine deacetylase (EC 3.5.1.16) from Escherichia coli (strain K12)
ARGE_ECOLI / P23908 Acetylornithine deacetylase; AO; Acetylornithinase; N-acetylornithinase; NAO; EC 3.5.1.16 from Escherichia coli (strain K12)
PFams: Peptidase_M28, Peptidase_M20, M20_dimer
383 amino acids: PaperBLAST, CDD
(similar to BRENDA::Q92Y75 from Cluster 1, but similarity to seed sequence is below thresholds)

W3Y6L2 Amidohydrolase
394 amino acids: PaperBLAST, CDD

SO3749 Acetylornithine deacetylase (EC:3.5.1.16) from Shewanella oneidensis MR-1
PFams: AstE_AspA
275 amino acids: PaperBLAST, CDD