Clusters of Characterized Proteins

Clustering the characterized proteins for artJ (L-arginine ABC transporter, periplasmic substrate-binding component ArtJ/HisJ/ArtI/AotJ/ArgT) in L-arginine catabolism

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Definition of artJ

• Curated sequence AO353_03055: ABC transporter for L-Arginine and L-Citrulline, periplasmic substrate-binding component
• Curated sequence CH_002541: arginine ABC transporter, periplasmic arginine-binding protein ArtJ. ABC transporter arginine-binding protein 1. ArtJ aka B0860, component of Arginine porter. L-arginine ABC transporter periplasmic binding protein (EC 7.4.2.1). L-arginine ABC transporter periplasmic binding protein (EC 7.4.2.1)
• Curated sequence CH_003045: lysine/arginine/ornithine ABC transporter, periplasmic lysine/arginine/ornithine-binding protein ArgT. Lysine/arginine/ornithine-binding periplasmic protein; LAO-binding protein
• Curated sequence CH_014295: histidine ABC transporter, periplasmic histidine-binding protein HisJ. Histidine-binding periplasmic protein, component of Histidine/Arginine/Lysine (basic amino acid) uptake porter, HisJ/ArgT/HisP/HisM/HisQ [R, R, C, M, M, respectively] (Gilson et al. 1982). HisJ binds L-His (preferred), but 1-methyl-L-His and 3-methyl-L-His also bind, while the dipeptide carnosine binds weakly; D-histidine and the histidine degradation products, histamine, urocanic acid and imidazole do not bind. L-Arg, homo-L-Arg, and post-translationally modified methylated Arg-analogs also bind with the exception of symmetric dimethylated-L-Arg. L-Lys and L-Orn show weaker interactions with HisJ and methylated and acetylated Lys variants show poor binding.The carboxylate groups of these amino acids and their variants are essential. histidine ABC transporter periplasmic binding protein (EC 7.4.2.1)
• Curated sequence P30859: Putative ABC transporter arginine-binding protein 2. ArtI aka B0863, component of Arginine porter
• Curated sequence O50181: AotJ aka PA0888, component of Arginine/ornithine (but not lysine) porter
• Curated sequence P09551: ArgT aka B2310, component of Histidine/Arginine/Lysine (basic amino acid) uptake porter, HisJ/ArgT/HisP/HisM/HisQ [R, R, C, M, M, respectively] (Gilson et al. 1982). HisJ binds L-His (preferred), but 1-methyl-L-His and 3-methyl-L-His also bind, while the dipeptide carnosine binds weakly; D-histidine and the histidine degradation products, histamine, urocanic acid and imidazole do not bind. L-Arg, homo-L-Arg, and post-translationally modified methylated Arg-analogs also bind with the exception of symmetric dimethylated-L-Arg. L-Lys and L-Orn show weaker interactions with HisJ and methylated and acetylated Lys variants show poor binding.The carboxylate groups of these amino acids and their variants are essential. lysine/arginine/ornithine ABC transporter periplasmic binding protein (EC 7.4.2.1)
• Curated sequence Q9HU31: Amino acid (Lysine/arginine/ornithine/histidine/octopine) ABC transporter periplasmic binding protein, component of Amino acid transporter, PA5152-PA5155. Probably transports numerous amino acids including lysine, arginine, histidine, D-alanine and D-valine (Johnson et al. 2008). Regulated by ArgR
• Curated sequence BPHYT_RS07735: ABC transporter for L-Arginine, periplasmic substrate-binding component
• Curated sequence GFF4245: ABC transporter for L-Arginine, substrate-binding component
• Curated sequence Pf1N1B4_3431: ABC transporter for L-Arginine and L-Citrulline, periplasmic substrate-binding component
• Curated sequence AO356_18700: L-Arginine ABC transporter, periplasmic substrate-binding component
• Curated sequence Pf6N2E2_5660: L-Arginine ABC transporter, periplasmic substrate-binding component
• Ignore hits to CH_018185 when looking for 'other' hits (histidine ABC transporter, periplasmic histidine-binding protein HisJ. Histidine-binding periplasmic protein; HBP)
• Ignore hits to AO356_09900 when looking for 'other' hits (ABC transporter for L-Lysine, periplasmic substrate-binding component)
• Ignore hits to Pf6N2E2_2958 when looking for 'other' hits (ABC transporter for L-Lysine, periplasmic substrate-binding component)
• Ignore hits to AO356_05495 when looking for 'other' hits (ABC transporter for L-Lysine, periplasmic substrate-binding component)
• UniProt sequence E4PNW5: SubName: Full=Extracellular solute-binding protein, family 3 {ECO:0000313|EMBL:ADP98795.1};
• Comment: Many ABC transporters are known for arginine, including E. coli artJQMP (which is specific for arginine) and E. coli hisQPM-argT (also transports lysine, ornithine) These systems are generally homologous, but the two permease components also similar to each other. To simplify the analysis, these were clustered at 40% identity instead of the usual 30% identity. Distantly related proteins from Chlamydia (ARTJ_CHLTR, ARTJ_CHLPN) are annotated as artJ but are not actually characterized, and the other components of this system seem to be absent. So Chlamydial "artJ" were not included. Ignore hisJ (CH_018185) from Salmonella and the P. fluorescens lysine transporter (AO356_09900), which has a subtle defect on arginine and may well transport it, and close homologs in other Pseudomonas. In Marinobacter adhaerens, the SBP (HP15_3031, E4PNW5) is somewhat diverged, but fitness data confirms it is involved.

Fetched 14 sequences

Running BLASTp

Found similarities, at above 30% identity and 75% coverage, for 14 of these sequences

Found 1 clusters of similar sequences. Download as table or as draft rules or view by organism

Cluster 1 243-264 amino acids (12/14 heteromeric)

b0860 L-arginine ABC transporter periplasmic binding protein (EC 7.4.2.1) from Escherichia coli K-12 substr. MG1655
P30860 L-arginine ABC transporter periplasmic binding protein (EC 7.4.2.1) from Escherichia coli (strain K12)
ARTJ_ECOLI / P30860 ABC transporter arginine-binding protein 1 from Escherichia coli (strain K12)
TC 3.A.1.3.3 / P30860 ArtJ aka B0860, component of Arginine porter from Escherichia coli
GB|BAA35574.1 arginine ABC transporter, periplasmic arginine-binding protein ArtJ from Escherichia coli K12
PFams: SBP_bac_3
Heteromeric, 243 amino acids: PaperBLAST, CDD, Compare to cluster

ARGT_SALTY / P02911 Lysine/arginine/ornithine-binding periplasmic protein; LAO-binding protein from Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
RF|NP_461297.1 lysine/arginine/ornithine ABC transporter, periplasmic lysine/arginine/ornithine-binding protein ArgT from Salmonella enterica subsp. enterica serovar Typhimurium
PFams: SBP_bac_3
260 amino acids: PaperBLAST, CDD, Compare to cluster

b2309 histidine ABC transporter periplasmic binding protein (EC 7.4.2.1) from Escherichia coli K-12 substr. MG1655
TC 3.A.1.3.29 / P0AEU0 Histidine-binding periplasmic protein, component of Histidine/Arginine/Lysine (basic amino acid) uptake porter, HisJ/ArgT/HisP/HisM/HisQ [R, R, C, M, M, respectively] (Gilson et al. 1982). HisJ binds L-His (preferred), but 1-methyl-L-His and 3-methyl-L-His also bind, while the dipeptide carnosine binds weakly; D-histidine and the histidine degradation products, histamine, urocanic acid and imidazole do not bind. L-Arg, homo-L-Arg, and post-translationally modified methylated Arg-analogs also bind with the exception of symmetric dimethylated-L-Arg. L-Lys and L-Orn show weaker interactions with HisJ and methylated and acetylated Lys variants show poor binding.The carboxylate groups of these amino acids and their variants are essential from Escherichia coli (strain K12)
GB|AAC75369.1 histidine ABC transporter, periplasmic histidine-binding protein HisJ from Escherichia coli
PFams: SBP_bac_3
Heteromeric, 260 amino acids: PaperBLAST, CDD, Compare to cluster

ARTI_ECOLI / P30859 Putative ABC transporter arginine-binding protein 2 from Escherichia coli (strain K12)
TC 3.A.1.3.3 / P30859 ArtI aka B0863, component of Arginine porter from Escherichia coli
PFams: SBP_bac_3
Heteromeric, 243 amino acids: PaperBLAST, CDD, Compare to cluster

TC 3.A.1.3.11 / O50181 AotJ aka PA0888, component of Arginine/ornithine (but not lysine) porter from Pseudomonas aeruginosa
PFams: SBP_bac_3, Lig_chan-Glu_bd
Heteromeric, 259 amino acids: PaperBLAST, CDD, Compare to cluster

b2310 lysine/arginine/ornithine ABC transporter periplasmic binding protein (EC 7.4.2.1) from Escherichia coli K-12 substr. MG1655
TC 3.A.1.3.1 / TC 3.A.1.3.29 / P09551 ArgT aka B2310, component of Histidine/Arginine/Lysine (basic amino acid) uptake porter, HisJ/ArgT/HisP/HisM/HisQ [R, R, C, M, M, respectively] (Gilson et al. 1982). HisJ binds L-His (preferred), but 1-methyl-L-His and 3-methyl-L-His also bind, while the dipeptide carnosine binds weakly; D-histidine and the histidine degradation products, histamine, urocanic acid and imidazole do not bind. L-Arg, homo-L-Arg, and post-translationally modified methylated Arg-analogs also bind with the exception of symmetric dimethylated-L-Arg. L-Lys and L-Orn show weaker interactions with HisJ and methylated and acetylated Lys variants show poor binding.The carboxylate groups of these amino acids and their variants are essential from Escherichia coli
PFams: SBP_bac_3
Heteromeric, 260 amino acids: PaperBLAST, CDD, Compare to cluster

TC 3.A.1.3.23 / Q9HU31 Amino acid (Lysine/arginine/ornithine/histidine/octopine) ABC transporter periplasmic binding protein, component of Amino acid transporter, PA5152-PA5155. Probably transports numerous amino acids including lysine, arginine, histidine, D-alanine and D-valine (Johnson et al. 2008). Regulated by ArgR from Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228)
PFams: SBP_bac_3, Lig_chan-Glu_bd
Heteromeric, 250 amino acids: PaperBLAST, CDD, Compare to cluster

E4PNW5 Extracellular solute-binding protein, family 3
250 amino acids: PaperBLAST, CDD, Compare to cluster

BPHYT_RS07735 ABC transporter for L-Arginine, periplasmic substrate-binding component from Burkholderia phytofirmans PsJN
PFams: SBP_bac_3, NMT1
Heteromeric, 264 amino acids: PaperBLAST, CDD, Compare to cluster

PS417_21745 ABC transporter for L-Arginine, substrate-binding component from Pseudomonas simiae WCS417
PFams: SBP_bac_3
Heteromeric, 261 amino acids: PaperBLAST, CDD, Compare to cluster

Pf1N1B4_3431 ABC transporter for L-Arginine and L-Citrulline, periplasmic substrate-binding component from Pseudomonas fluorescens FW300-N1B4
PFams: SBP_bac_3, Lig_chan-Glu_bd
Heteromeric, 257 amino acids: PaperBLAST, CDD, Compare to cluster

AO353_03055 ABC transporter for L-Arginine and L-Citrulline, periplasmic substrate-binding component from Pseudomonas fluorescens FW300-N2E3
PFams: SBP_bac_3
Heteromeric, 258 amino acids: PaperBLAST, CDD, Compare to cluster

AO356_18700 L-Arginine ABC transporter, periplasmic substrate-binding component from Pseudomonas fluorescens FW300-N2C3
PFams: SBP_bac_3, Lig_chan-Glu_bd
Heteromeric, 257 amino acids: PaperBLAST, CDD, Compare to cluster

Pf6N2E2_5660 L-Arginine ABC transporter, periplasmic substrate-binding component from Pseudomonas fluorescens FW300-N2E2
PFams: SBP_bac_3, Lig_chan-Glu_bd
Heteromeric, 257 amino acids: PaperBLAST, CDD, Compare to cluster