Clusters of Characterized Proteins

Clustering the characterized proteins for artM (L-arginine ABC transporter, permease component 1 (ArtM/HisM/AotM)) in L-arginine catabolism

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Definition of artM

• Curated sequence P0A2I7: Histidine transport system permease protein HisM. Histidine transport system permease protein HisM aka STM2352, component of Histidine/arginine/lysine/ornithine porter (Heuveling et al. 2014). In contrast to some homologous homodimeric systems, the heterodimeric histidine transporter of Salmonella enterica Typhimurium
• Curated sequence P0AEU3: Histidine transport system permease protein HisM. Histidine transport system permease protein HisM, component of Histidine/Arginine/Lysine (basic amino acid) uptake porter, HisJ/ArgT/HisP/HisM/HisQ [R, R, C, M, M, respectively] (Gilson et al. 1982). HisJ binds L-His (preferred), but 1-methyl-L-His and 3-methyl-L-His also bind, while the dipeptide carnosine binds weakly; D-histidine and the histidine degradation products, histamine, urocanic acid and imidazole do not bind. L-Arg, homo-L-Arg, and post-translationally modified methylated Arg-analogs also bind with the exception of symmetric dimethylated-L-Arg. L-Lys and L-Orn show weaker interactions with HisJ and methylated and acetylated Lys variants show poor binding.The carboxylate groups of these amino acids and their variants are essential. lysine/arginine/ornithine ABC transporter / histidine ABC transporter, membrane subunit HisM (EC 7.4.2.1)
• Curated sequence O50183: AotP aka AotM aka PA0890, component of Arginine/ornithine (but not lysine) porter
• Curated sequence Q9HU29: Amino acid (Lysine/arginine/ornithine/histidine/octopine) ABC transporter membrane protein, component of Amino acid transporter, PA5152-PA5155. Probably transports numerous amino acids including lysine, arginine, histidine, D-alanine and D-valine (Johnson et al. 2008). Regulated by ArgR
• Curated sequence BPHYT_RS07680: ABC transporter for L-Arginine, permease component 1
• Curated sequence GFF4243: ABC transporter for L-Arginine, permease component 2
• Curated sequence Pf1N1B4_3433: ABC transporter for L-Arginine and L-Citrulline, permease component 2
• Curated sequence AO353_03045: ABC transporter for L-Arginine and L-Citrulline, permease component 1
• Curated sequence AO356_18710: L-Arginine ABC transporter, permease component 1
• Curated sequence Pf6N2E2_5662: L-Arginine ABC transporter, permease protein AotM
• Curated sequence P0AE30: Arginine ABC transporter permease protein ArtM. Arginine transport system permease protein ArtM aka B0861, component of Arginine porter. L-arginine ABC transporter membrane subunit ArtM (EC 7.4.2.1). L-arginine ABC transporter membrane subunit ArtM (EC 7.4.2.1)
• Ignore hits to AO356_09910 when looking for 'other' hits (ABC transporter for L-Lysine, permease component 2)
• Ignore hits to Pf6N2E2_2960 when looking for 'other' hits (ABC transporter for L-Lysine, permease component 2)
• Ignore hits to AO356_05505 when looking for 'other' hits (ABC transporter for L-Lysine, permease component 2)
• Comment: ArtM and HisM are distantly related and were combined. TC 1.B.6.2.7 / F9GZA7 is annotated as ArtM but seems more likely to be an outer membrane porin, so it is not included. Ignore closely related lysine transporters from P. fluorescens (which may well transport arginine; AO356_09910 has a subtle defect in arginine utilization).

Fetched 11 sequences

Running BLASTp

Found similarities, at above 30% identity and 75% coverage, for 11 of these sequences

Found 1 clusters of similar sequences. Download as table or as draft rules or view by organism

Cluster 1 222-238 amino acids (10/11 heteromeric)

HISM_SALTY / P0A2I7 Histidine transport system permease protein HisM from Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
TC 3.A.1.3.1 / P0A2I7 Histidine transport system permease protein HisM aka STM2352, component of Histidine/arginine/lysine/ornithine porter (Heuveling et al. 2014). In contrast to some homologous homodimeric systems, the heterodimeric histidine transporter of Salmonella enterica Typhimurium from Salmonella typhimurium
PFams: BPD_transp_1
Heteromeric, 235 amino acids: PaperBLAST, CDD, Compare to cluster

b0861 L-arginine ABC transporter membrane subunit ArtM (EC 7.4.2.1) from Escherichia coli K-12 substr. MG1655
P0AE30 L-arginine ABC transporter membrane subunit ArtM (EC 7.4.2.1) from Escherichia coli (strain K12)
ARTM_ECOLI / P0AE30 Arginine ABC transporter permease protein ArtM from Escherichia coli (strain K12)
TC 3.A.1.3.3 / P0AE30 Arginine transport system permease protein ArtM aka B0861, component of Arginine porter from Escherichia coli
PFams: BPD_transp_1
Heteromeric, 222 amino acids: PaperBLAST, CDD, Compare to cluster

b2307 lysine/arginine/ornithine ABC transporter / histidine ABC transporter, membrane subunit HisM (EC 7.4.2.1) from Escherichia coli K-12 substr. MG1655
HISM_ECOLI / P0AEU3 Histidine transport system permease protein HisM from Escherichia coli (strain K12)
TC 3.A.1.3.29 / P0AEU3 Histidine transport system permease protein HisM, component of Histidine/Arginine/Lysine (basic amino acid) uptake porter, HisJ/ArgT/HisP/HisM/HisQ [R, R, C, M, M, respectively] (Gilson et al. 1982). HisJ binds L-His (preferred), but 1-methyl-L-His and 3-methyl-L-His also bind, while the dipeptide carnosine binds weakly; D-histidine and the histidine degradation products, histamine, urocanic acid and imidazole do not bind. L-Arg, homo-L-Arg, and post-translationally modified methylated Arg-analogs also bind with the exception of symmetric dimethylated-L-Arg. L-Lys and L-Orn show weaker interactions with HisJ and methylated and acetylated Lys variants show poor binding.The carboxylate groups of these amino acids and their variants are essential from Escherichia coli (strain K12)
PFams: BPD_transp_1
Heteromeric, 238 amino acids: PaperBLAST, CDD, Compare to cluster

TC 3.A.1.3.11 / O50183 AotP aka AotM aka PA0890, component of Arginine/ornithine (but not lysine) porter from Pseudomonas aeruginosa
PFams: BPD_transp_1
Heteromeric, 232 amino acids: PaperBLAST, CDD, Compare to cluster

TC 3.A.1.3.23 / Q9HU29 Amino acid (Lysine/arginine/ornithine/histidine/octopine) ABC transporter membrane protein, component of Amino acid transporter, PA5152-PA5155. Probably transports numerous amino acids including lysine, arginine, histidine, D-alanine and D-valine (Johnson et al. 2008). Regulated by ArgR from Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228)
PFams: BPD_transp_1
Heteromeric, 230 amino acids: PaperBLAST, CDD, Compare to cluster

BPHYT_RS07680 ABC transporter for L-Arginine, permease component 1 from Burkholderia phytofirmans PsJN
PFams: BPD_transp_1
Heteromeric, 237 amino acids: PaperBLAST, CDD, Compare to cluster

PS417_21735 ABC transporter for L-Arginine, permease component 2 from Pseudomonas simiae WCS417
PFams: BPD_transp_1
Heteromeric, 232 amino acids: PaperBLAST, CDD, Compare to cluster

Pf1N1B4_3433 ABC transporter for L-Arginine and L-Citrulline, permease component 2 from Pseudomonas fluorescens FW300-N1B4
PFams: BPD_transp_1
Heteromeric, 232 amino acids: PaperBLAST, CDD, Compare to cluster

AO353_03045 ABC transporter for L-Arginine and L-Citrulline, permease component 1 from Pseudomonas fluorescens FW300-N2E3
PFams: BPD_transp_1
Heteromeric, 232 amino acids: PaperBLAST, CDD, Compare to cluster

AO356_18710 L-Arginine ABC transporter, permease component 1 from Pseudomonas fluorescens FW300-N2C3
PFams: BPD_transp_1
Heteromeric, 232 amino acids: PaperBLAST, CDD, Compare to cluster

Pf6N2E2_5662 L-Arginine ABC transporter, permease protein AotM from Pseudomonas fluorescens FW300-N2E2
PFams: BPD_transp_1
232 amino acids: PaperBLAST, CDD, Compare to cluster