Clusters of Characterized Proteins

GapMind for catabolism of small carbon sources

Clusters of Characterized Proteins

Clustering the characterized proteins for lhgD (L-2-hydroxyglutarate dehydrogenase or oxidase (LhgD or LhgO)) in L-arginine catabolism

Or see other characterized proteins similar to lhgD

Or see all steps for L-arginine catabolism

Or cluster curated proteins matching a keyword

Definition of lhgD

Curated proteins or TIGRFams with EC 1.1.5.13
Curated sequence G1G01-3089-MONOMER: (S)-2-hydroxyglutarate oxidase
Curated proteins or TIGRFams with EC 1.1.99.2
Comment: As discussed in the MetaCyc page for lhgO (G1G01-3089-MONOMER), there is some controversy as to whether the E. coli enzyme (lhgD) uses quinone or oxygen as its acceptor; the Pseudomonas protein (G1G01-3089-MONOMER) does use oxygen.

Fetched 4 sequences

Running BLASTp

Found similarities, at above 30% identity and 75% coverage, for 3 of these sequences

Found 1 clusters of similar sequences. Another 1 sequences are not clustered. Download as table or as draft rules or view by organism

Cluster 1 416-463 amino acids (not heteromeric)

The first sequence in each cluster is the seed.

L2HDH_HUMAN / Q9H9P8 L-2-hydroxyglutarate dehydrogenase, mitochondrial; Duranin; EC 1.1.99.2 from Homo sapiens (Human)
Q9H9P8 L-2-hydroxyglutarate dehydrogenase (EC 1.1.99.2) from Homo sapiens
PFams: DAO
463 amino acids: PaperBLAST, CDD, Compare to cluster

b2660 L-2-hydroxyglutarate dehydrogenase (EC 1.1.5.13) from Escherichia coli K-12 substr. MG1655
P37339 L-2-hydroxyglutarate dehydrogenase (EC 1.1.5.13) from Escherichia coli (strain K12)
LHGD_ECOLI / P37339 L-2-hydroxyglutarate dehydrogenase; L2HG dehydrogenase; L2HG:quinone oxidoreductase; EC 1.1.5.- from Escherichia coli (strain K12)
PFams: DAO
422 amino acids: PaperBLAST, CDD, Compare to cluster

Q88IT9 (S)-2-hydroxyglutarate oxidase from Pseudomonas putida (strain ATCC 47054 / DSM 6125 / NCIMB 11950 / KT2440)
PFams: DAO
416 amino acids: PaperBLAST, CDD, Compare to cluster

Singletons (0/1 heteromeric)

L2HDH_ARATH / Q9LES4 L-2-hydroxyglutarate dehydrogenase, mitochondrial; EC 1.1.99.2 from Arabidopsis thaliana (Mouse-ear cress)
PFams: DAO, NAD_binding_8
483 amino acids: PaperBLAST, CDD