Clusters of Characterized Proteins

Clustering the characterized proteins for glt (aspartate:proton symporter Glt) in L-aspartate catabolism

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Definition of glt

• Curated sequence P21345: Proton/glutamate-aspartate symporter; Glutamate-aspartate carrier protein; Proton-glutamate-aspartate transport protein. Glutamate/aspartate:H+ symporter, GltP or GltT; has 8 TMSs with 2 re-entrant loops as for GltPh (TC# 2.A.23.1.5). glutamate/aspartate : H⁺ symporter GltP
• Curated sequence CH_014038: aerobic C4-dicarboxylate transport protein. Aerobic C4-dicarboxylate transport protein. Aerobic dicarboxylate transporter, DctA. Interacts with the DcuS sensor kinase. C4 dicarboxylate/orotate:H⁺ symporter. C4 dicarboxylate/orotate:H⁺ symporter
• UniProt sequence A0A0N9WTL5: SubName: Full=Amino acid:proton symporter {ECO:0000313|EMBL:ALI05583.1};
• UniProt sequence A0A0C4Y5S4: SubName: Full=Uncharacterized protein {ECO:0000313|EMBL:AJG18233.1};
• Curated sequence CH_088342: proton/sodium-glutamate symport protein GltT. Proton/sodium-glutamate symport protein; Glutamate-aspartate carrier protein
• Curated sequence P24943: Proton/sodium-glutamate symport protein; Glutamate-aspartate carrier protein. proton/sodium-glutamate symport protein GltT. Glutamate/aspartate:Na+ + H+ symporter
• Curated sequence P43003: Excitatory amino acid transporter 1; Sodium-dependent glutamate/aspartate transporter 1; GLAST-1; Solute carrier family 1 member 3. Excitatory amino acid transporter 1 (EAAT1) (Sodium-dependent glutamate/aspartate transporter 1) (GLAST-1) (Solute carrier family 1 member 3)
• Curated sequence CH_091614: excitatory amino acid transporter 1. Excitatory amino acid transporter 1; Glial glutamate transporter; Sodium-dependent glutamate/aspartate transporter 1; GLAST; GLAST-1; Solute carrier family 1 member 3. Glutamate/aspartate:Na+ symporter, GLAST or EAAT1, Structural rearrangements have been probed by Leighton et al., 2006). EAAT1 interacts directly with the Na+, K+-ATPase (TC #3.A.3.1) (Rose et al., 2009). CEAT1 couples glutamate uptake to the symport of 3 Na+ and 1 H+ followed by the antiport of 1 K+. It can function as an uncoupled anion, water and/or urea channel (Vandenberg et al., 2011). Large collective motions regulate the functional properties of EAAT1 trimers
• Curated sequence O35544: Excitatory amino acid transporter 4; High-affinity neuronal glutamate transporter; Sodium-dependent glutamate/aspartate transporter; Solute carrier family 1 member 6
• Curated sequence O35921: Excitatory amino acid transporter 4; High-affinity neuronal glutamate transporter; Sodium-dependent glutamate/aspartate transporter; Solute carrier family 1 member 6
• Curated sequence O57321: Excitatory amino acid transporter 1; SEAAT1; Sodium-dependent glutamate/aspartate transporter; GLAST
• Curated sequence O59010: Glutamate transporter homolog; Glt(Ph); Sodium-aspartate symporter Glt(Ph); Sodium-dependent aspartate transporter. Archaeal aspartate transporter, Gltph (GltPh) (3-D structure known; 3V8F and 3V8G) (Boudker et al., 2007; Yernool et al., 2004). Cotransports aspartate with 2 Na+ (Ryan et al., 2009) or 3 Na+ (Groeneveld and Slotboom, 2010) or 1Na+ plus 1 H+ plus 1 K+
• Curated sequence P24943: Proton/sodium-glutamate symport protein; Glutamate-aspartate carrier protein. proton/sodium-glutamate symport protein GltT. Glutamate/aspartate:Na+ + H+ symporter
• Curated sequence P31596: Excitatory amino acid transporter 2; GLT-1; Sodium-dependent glutamate/aspartate transporter 2; GLUT-R; Solute carrier family 1 member 2. Glutamate/aspartate:Na+ symporter, GLT1; GLUT-R; EAAT2. Interacts directly with the Na+, K+-ATPase (TC #3.A.3.1) (Rose et al., 2009). Cotransports glutamic acid with three Na+ followed by countertransport of K+ (Teichman et al., 2009). The C-terminal 74aa domain regulates transport activity (Leinenweber et al., 2011). Hippocampal glutamate transporter 1 (GLT-1) levels parallel memory training (Heo et al., 2011). GLT-1 is regulated by MAGI-1
• Curated sequence P31597: Excitatory amino acid transporter 3; Excitatory amino-acid carrier 1; Sodium-dependent glutamate/aspartate transporter 3; Solute carrier family 1 member 1
• Curated sequence P43004: Excitatory amino acid transporter 2; Glutamate/aspartate transporter II; Sodium-dependent glutamate/aspartate transporter 2; Solute carrier family 1 member 2. Excitatory amino acid transporter 2, EAAT2 (Glutamate/aspartate transporter II) (Sodium-dependent glutamate/aspartate transporter 2) (Solute carrier family 1 member 2)
• Curated sequence P43005: Excitatory amino acid transporter 3; Excitatory amino-acid carrier 1; Neuronal and epithelial glutamate transporter; Sodium-dependent glutamate/aspartate transporter 3; Solute carrier family 1 member 1. Glutamate/aspartate/cysteine:Na+ symporter, EAAC1; EAAT3, SLC1A1 (Li+ can replace Na+; EAAC1 also mediates glutamate-independent anion conductance.) Cotransports glutamic acid with three Na+ followed by countertransport of K+(Teichman et al., 2009). The 50 residue 4B-4C loop (following TMS4) binds Na+ (Koch et al., 2007). (The dicarboxylic aminoaciduria protein in humans; NP_004161; Bröer, 2008a; 2008b). Neutralizing aspartate 83 modifies substrate translocation
• Curated sequence P43006: Excitatory amino acid transporter 2; GLT-1; Sodium-dependent glutamate/aspartate transporter 2; Solute carrier family 1 member 2
• Curated sequence P46411: Excitatory amino acid transporter 1; Sodium-dependent glutamate/aspartate transporter 1; GLAST-1; Solute carrier family 1 member 3
• Curated sequence P48664: Excitatory amino acid transporter 4; Sodium-dependent glutamate/aspartate transporter; Solute carrier family 1 member 6. Excitatory amino acid transporter 4, EAAT4 (Sodium-dependent glutamate/aspartate transporter) (Solute carrier family 1 member 6)
• Curated sequence P51906: Excitatory amino acid transporter 3; Excitatory amino-acid carrier 1; Sodium-dependent glutamate/aspartate transporter 3; Solute carrier family 1 member 1
• Curated sequence P51907: Excitatory amino acid transporter 3; Excitatory amino-acid carrier 1; Sodium-dependent glutamate/aspartate transporter 3; Solute carrier family 1 member 1
• Curated sequence P56564: Excitatory amino acid transporter 1; Glial high affinity glutamate transporter; High-affinity neuronal glutamate transporter; GluT-1; Sodium-dependent glutamate/aspartate transporter 1; GLAST-1; Solute carrier family 1 member 3
• Curated sequence Q9N1R2: Excitatory amino acid transporter 4; Sodium-dependent glutamate/aspartate transporter; Solute carrier family 1 member 6
• Curated sequence B0W0K4: EAAT homologue, a glutamate/aspartate preferring transporter of 483 aas
• Curated sequence Q10901: Excitatory amino acid transporter (Sodium-dependent glutamate/aspartate transporter), Gkt-1 of 503 aas and 9 - 11 TMSs
• Curated sequence Q8T0S9: Aspartate/taurine (not glutamate):Na+ symporter, dEAAT2 (mediates both uptake and heteroexchange of its two substrates, both dependent on external Na+ (with taurine outside and Asp inside)); L-glutamate is transported with low affinity and efficiency
• Curated sequence CH_088342: proton/sodium-glutamate symport protein GltT. Proton/sodium-glutamate symport protein; Glutamate-aspartate carrier protein
• Ignore hits to Q9N280 when looking for 'other' hits (glucuronosyltransferase (EC 2.4.1.17))
• Curated sequence P39817: Proton/glutamate-aspartate symporter; Proton/glutamate symport protein
• UniProt sequence A1S570: SubName: Full=Sodium:dicarboxylate symporter {ECO:0000313|EMBL:ABL99526.1};
• Comment: The original cluster was entirely eukaryotic except for gltPh from Pyrococcus horikoshii. Added gltT from Bacillus caldotenax (CharProtDB::CH_088342), which is also an aspartate transporter. So, named it glt. Ignore Q9N280 which has a questionable annotation in BRENDA. But the more distantly related protein AO356_01905 (A0A0N9WTL5) also seems to be an aspartate transporter. Similarly, the related protein RR42_RS03990 (A0A0C4Y5S4) is specifically important for asparagine utilization. Asparagine is probably cleaved in the periplasm (by RR42_RS12610 or RR42_RS26140) so this is probably an aspartate transporter as well. And the related protein P24944 (CH_088342) or P24943 is an aspartate transporter. This cluster also includes the aspartate transporter DctA from E. coli; it is almost 80% identical to Pseudomonas dicarboxylate transporters whose activity on aspartate is uncertain. As these are not important for aspartate utilization (AO356_18980, AO353_02800), do not mark them as ignored. The gltP from B. subtilis (P39817) was added manually. A related aspartate/glutamate transporter was identified in Shewanella amazonensis SB2B (Sama_1319, A1S570) using fitness data.

Fetched 28 sequences

Running BLASTp

Found similarities, at above 30% identity and 75% coverage, for 28 of these sequences

Found 2 clusters of similar sequences. Download as table or as draft rules or view by organism

Cluster 1 414-574 amino acids (not heteromeric)

A1S570 Sodium:dicarboxylate symporter
437 amino acids: PaperBLAST, CDD, Compare to cluster

b3528 C4 dicarboxylate/orotate:H⁺ symporter from Escherichia coli K-12 substr. MG1655
P0A830 C4 dicarboxylate/orotate:H⁺ symporter from Escherichia coli (strain K12)
DCTA_ECOLI / P0A830 Aerobic C4-dicarboxylate transport protein from Escherichia coli (strain K12)
TC 2.A.23.1.7 / P0A830 Aerobic dicarboxylate transporter, DctA. Interacts with the DcuS sensor kinase from Escherichia coli (strain K12)
GB|AAC76553.1 aerobic C4-dicarboxylate transport protein from Escherichia coli
PFams: SDF
428 amino acids: PaperBLAST, CDD, Compare to cluster

GLTT_BACCA / P24944 Proton/sodium-glutamate symport protein; Glutamate-aspartate carrier protein from Bacillus caldotenax
GI|143002 proton/sodium-glutamate symport protein GltT from Bacillus caldotenax
PFams: SDF
421 amino acids: PaperBLAST, CDD, Compare to cluster

EAA1_RAT / P24942 Excitatory amino acid transporter 1; Glial glutamate transporter; Sodium-dependent glutamate/aspartate transporter 1; GLAST; GLAST-1; Solute carrier family 1 member 3 from Rattus norvegicus (Rat)
TC 2.A.23.2.1 / P24942 Glutamate/aspartate:Na+ symporter, GLAST or EAAT1, Structural rearrangements have been probed by Leighton et al., 2006). EAAT1 interacts directly with the Na+, K+-ATPase (TC #3.A.3.1) (Rose et al., 2009). CEAT1 couples glutamate uptake to the symport of 3 Na+ and 1 H+ followed by the antiport of 1 K+. It can function as an uncoupled anion, water and/or urea channel (Vandenberg et al., 2011). Large collective motions regulate the functional properties of EAAT1 trimers from Rattus norvegicus (Rat)
RF|NP_062098.1 excitatory amino acid transporter 1 from Rattus norvegicus
PFams: SDF
543 amino acids: PaperBLAST, CDD, Compare to cluster

EAA1_AMBTI / O57321 Excitatory amino acid transporter 1; SEAAT1; Sodium-dependent glutamate/aspartate transporter; GLAST from Ambystoma tigrinum (Eastern tiger salamander)
PFams: SDF
543 amino acids: PaperBLAST, CDD, Compare to cluster

GLT_PYRHO / O59010 Glutamate transporter homolog; Glt(Ph); Sodium-aspartate symporter Glt(Ph); Sodium-dependent aspartate transporter from Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3)
TC 2.A.23.1.5 / O59010 Archaeal aspartate transporter, Gltph (GltPh) (3-D structure known; 3V8F and 3V8G) (Boudker et al., 2007; Yernool et al., 2004). Cotransports aspartate with 2 Na+ (Ryan et al., 2009) or 3 Na+ (Groeneveld and Slotboom, 2010) or 1Na+ plus 1 H+ plus 1 K+ from Pyrococcus horikoshii
PFams: SDF
425 amino acids: PaperBLAST, CDD, Compare to cluster

b4077 glutamate/aspartate : H⁺ symporter GltP from Escherichia coli K-12 substr. MG1655
GLTP_ECOLI / P21345 Proton/glutamate-aspartate symporter; Glutamate-aspartate carrier protein; Proton-glutamate-aspartate transport protein from Escherichia coli (strain K12)
TC 2.A.23.1.1 / P21345 Glutamate/aspartate:H+ symporter, GltP or GltT; has 8 TMSs with 2 re-entrant loops as for GltPh (TC# 2.A.23.1.5) from Escherichia coli
PFams: SDF
437 amino acids: PaperBLAST, CDD, Compare to cluster

GLTT_GEOSE / P24943 Proton/sodium-glutamate symport protein; Glutamate-aspartate carrier protein from Geobacillus stearothermophilus (Bacillus stearothermophilus)
TC 2.A.23.1.2 / P24943 Glutamate/aspartate:Na+ + H+ symporter from Bacillus stearothermophilus
GI|143000 proton/sodium-glutamate symport protein GltT from Geobacillus stearothermophilus
PFams: SDF
421 amino acids: PaperBLAST, CDD, Compare to cluster

EAA2_RAT / P31596 Excitatory amino acid transporter 2; GLT-1; Sodium-dependent glutamate/aspartate transporter 2; GLUT-R; Solute carrier family 1 member 2 from Rattus norvegicus (Rat)
TC 2.A.23.2.2 / P31596 Glutamate/aspartate:Na+ symporter, GLT1; GLUT-R; EAAT2. Interacts directly with the Na+, K+-ATPase (TC #3.A.3.1) (Rose et al., 2009). Cotransports glutamic acid with three Na+ followed by countertransport of K+ (Teichman et al., 2009). The C-terminal 74aa domain regulates transport activity (Leinenweber et al., 2011). Hippocampal glutamate transporter 1 (GLT-1) levels parallel memory training (Heo et al., 2011). GLT-1 is regulated by MAGI-1 from Rattus norvegicus (Rat)
PFams: SDF
573 amino acids: PaperBLAST, CDD, Compare to cluster

EAA3_RABIT / P31597 Excitatory amino acid transporter 3; Excitatory amino-acid carrier 1; Sodium-dependent glutamate/aspartate transporter 3; Solute carrier family 1 member 1 from Oryctolagus cuniculus (Rabbit)
PFams: SDF
524 amino acids: PaperBLAST, CDD, Compare to cluster

GLTP_BACSU / P39817 Proton/glutamate-aspartate symporter; Proton/glutamate symport protein from Bacillus subtilis (strain 168)
PFams: SDF
414 amino acids: PaperBLAST, CDD, Compare to cluster

EAA1_HUMAN / P43003 Excitatory amino acid transporter 1; Sodium-dependent glutamate/aspartate transporter 1; GLAST-1; Solute carrier family 1 member 3 from Homo sapiens (Human)
TC 2.A.23.2.6 / P43003 Excitatory amino acid transporter 1 (EAAT1) (Sodium-dependent glutamate/aspartate transporter 1) (GLAST-1) (Solute carrier family 1 member 3) from Homo sapiens
PFams: SDF
542 amino acids: PaperBLAST, CDD, Compare to cluster

EAA2_HUMAN / P43004 Excitatory amino acid transporter 2; Glutamate/aspartate transporter II; Sodium-dependent glutamate/aspartate transporter 2; Solute carrier family 1 member 2 from Homo sapiens (Human)
TC 2.A.23.2.7 / P43004 Excitatory amino acid transporter 2, EAAT2 (Glutamate/aspartate transporter II) (Sodium-dependent glutamate/aspartate transporter 2) (Solute carrier family 1 member 2) from Homo sapiens
PFams: SDF
574 amino acids: PaperBLAST, CDD, Compare to cluster

EAA3_HUMAN / P43005 Excitatory amino acid transporter 3; Excitatory amino-acid carrier 1; Neuronal and epithelial glutamate transporter; Sodium-dependent glutamate/aspartate transporter 3; Solute carrier family 1 member 1 from Homo sapiens (Human)
TC 2.A.23.2.3 / P43005 Glutamate/aspartate/cysteine:Na+ symporter, EAAC1; EAAT3, SLC1A1 (Li+ can replace Na+; EAAC1 also mediates glutamate-independent anion conductance.) Cotransports glutamic acid with three Na+ followed by countertransport of K+(Teichman et al., 2009). The 50 residue 4B-4C loop (following TMS4) binds Na+ (Koch et al., 2007). (The dicarboxylic aminoaciduria protein in humans; NP_004161; Bröer, 2008a; 2008b). Neutralizing aspartate 83 modifies substrate translocation from Homo sapiens (Human)
PFams: SDF
524 amino acids: PaperBLAST, CDD, Compare to cluster

EAA2_MOUSE / P43006 Excitatory amino acid transporter 2; GLT-1; Sodium-dependent glutamate/aspartate transporter 2; Solute carrier family 1 member 2 from Mus musculus (Mouse)
PFams: SDF
572 amino acids: PaperBLAST, CDD, Compare to cluster

EAA1_BOVIN / P46411 Excitatory amino acid transporter 1; Sodium-dependent glutamate/aspartate transporter 1; GLAST-1; Solute carrier family 1 member 3 from Bos taurus (Bovine)
PFams: SDF
542 amino acids: PaperBLAST, CDD, Compare to cluster

EAA3_MOUSE / P51906 Excitatory amino acid transporter 3; Excitatory amino-acid carrier 1; Sodium-dependent glutamate/aspartate transporter 3; Solute carrier family 1 member 1 from Mus musculus (Mouse)
PFams: SDF
523 amino acids: PaperBLAST, CDD, Compare to cluster

EAA3_RAT / P51907 Excitatory amino acid transporter 3; Excitatory amino-acid carrier 1; Sodium-dependent glutamate/aspartate transporter 3; Solute carrier family 1 member 1 from Rattus norvegicus (Rat)
PFams: SDF
523 amino acids: PaperBLAST, CDD, Compare to cluster

EAA1_MOUSE / P56564 Excitatory amino acid transporter 1; Glial high affinity glutamate transporter; High-affinity neuronal glutamate transporter; GluT-1; Sodium-dependent glutamate/aspartate transporter 1; GLAST-1; Solute carrier family 1 member 3 from Mus musculus (Mouse)
PFams: SDF
543 amino acids: PaperBLAST, CDD, Compare to cluster

TC 2.A.23.2.11 / B0W0K4 EAAT homologue, a glutamate/aspartate preferring transporter of 483 aas from Culex quinquefasciatus
PFams: SDF
483 amino acids: PaperBLAST, CDD, Compare to cluster

TC 2.A.23.2.10 / Q10901 Excitatory amino acid transporter (Sodium-dependent glutamate/aspartate transporter), Gkt-1 of 503 aas and 9 - 11 TMSs from Caenorhabditis elegans
PFams: SDF
503 amino acids: PaperBLAST, CDD, Compare to cluster

A0A0C4Y5S4 Uncharacterized protein
436 amino acids: PaperBLAST, CDD, Compare to cluster

A0A0N9WTL5 Amino acid:proton symporter
431 amino acids: PaperBLAST, CDD, Compare to cluster

Cluster 2 561-579 amino acids (not heteromeric)

EAA4_MOUSE / O35544 Excitatory amino acid transporter 4; High-affinity neuronal glutamate transporter; Sodium-dependent glutamate/aspartate transporter; Solute carrier family 1 member 6 from Mus musculus (Mouse)
PFams: SDF
561 amino acids: PaperBLAST, CDD, Compare to cluster

EAA4_RAT / O35921 Excitatory amino acid transporter 4; High-affinity neuronal glutamate transporter; Sodium-dependent glutamate/aspartate transporter; Solute carrier family 1 member 6 from Rattus norvegicus (Rat)
PFams: SDF
561 amino acids: PaperBLAST, CDD, Compare to cluster

EAA4_HUMAN / P48664 Excitatory amino acid transporter 4; Sodium-dependent glutamate/aspartate transporter; Solute carrier family 1 member 6 from Homo sapiens (Human)
TC 2.A.23.2.8 / P48664 Excitatory amino acid transporter 4, EAAT4 (Sodium-dependent glutamate/aspartate transporter) (Solute carrier family 1 member 6) from Homo sapiens
PFams: SDF
564 amino acids: PaperBLAST, CDD, Compare to cluster

EAA4_CANLF / Q9N1R2 Excitatory amino acid transporter 4; Sodium-dependent glutamate/aspartate transporter; Solute carrier family 1 member 6 from Canis lupus familiaris (Dog) (Canis familiaris)
PFams: SDF
564 amino acids: PaperBLAST, CDD, Compare to cluster

TC 2.A.23.2.4 / Q8T0S9 Aspartate/taurine (not glutamate):Na+ symporter, dEAAT2 (mediates both uptake and heteroexchange of its two substrates, both dependent on external Na+ (with taurine outside and Asp inside)); L-glutamate is transported with low affinity and efficiency from Drosophila melanogaster (Fruit fly)
PFams: SDF
579 amino acids: PaperBLAST, CDD, Compare to cluster