Clusters of Characterized Proteins

Clustering the characterized proteins for mglC (glucose ABC transporter, permease component (MglC)) in D-cellobiose catabolism

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Definition of mglC

• Curated sequence G4FGN4: Putative beta-xyloside ABC transporter, permease component, component of Glucose porter. Also bind xylose (Boucher and Noll 2011). Induced by glucose (Frock et al. 2012). Directly regulated by glucose-responsive regulator GluR
• Curated sequence P23200: MglC aka B2148, component of Galactose/glucose (methyl galactoside) porter. D-galactose/methyl-galactoside ABC transporter membrane subunit. D-galactose/methyl-galactoside ABC transporter membrane subunit
• Curated sequence O05177: GguB aka ATU2346 aka AGR_C_4262, component of Multiple sugar (arabinose, xylose, galactose, glucose, fucose) putative porter
• Curated sequence GFF3640: glucose transporter, permease component
• Ignore hits to D4GPW2 when looking for 'other' hits (Glucose ABC transporter permease protein TsgB13)
• Comment: mglC (b2148) and related proteins, and a protein from Haloferax (TSGBD_HALVD / D4GPW2; TSGDD_HALVD / D4GPW3)

Fetched 4 sequences

Running BLASTp

Found similarities, at above 30% identity and 75% coverage, for 4 of these sequences

Found 2 clusters of similar sequences. Download as table or as draft rules or view by organism

Cluster 1 398-433 amino acids (heteromeric)

TC 3.A.1.2.5 / O05177 GguB aka ATU2346 aka AGR_C_4262, component of Multiple sugar (arabinose, xylose, galactose, glucose, fucose) putative porter from Agrobacterium radiobacter
PFams: BPD_transp_2
Heteromeric, 398 amino acids: PaperBLAST, CDD, Compare to cluster

PGA1_262p00440 glucose transporter, permease component from Phaeobacter inhibens BS107
PFams: BPD_transp_2
Heteromeric, 433 amino acids: PaperBLAST, CDD, Compare to cluster

Cluster 2 313-336 amino acids (heteromeric)

TC 3.A.1.2.20 / G4FGN4 Putative beta-xyloside ABC transporter, permease component, component of Glucose porter. Also bind xylose (Boucher and Noll 2011). Induced by glucose (Frock et al. 2012). Directly regulated by glucose-responsive regulator GluR from Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
PFams: BPD_transp_2
Heteromeric, 313 amino acids: PaperBLAST, CDD, Compare to cluster

b2148 D-galactose/methyl-galactoside ABC transporter membrane subunit from Escherichia coli K-12 substr. MG1655
P23200 D-galactose/methyl-galactoside ABC transporter membrane subunit from Escherichia coli (strain K12)
TC 3.A.1.2.3 / P23200 MglC aka B2148, component of Galactose/glucose (methyl galactoside) porter from Escherichia coli
PFams: BPD_transp_2
Heteromeric, 336 amino acids: PaperBLAST, CDD, Compare to cluster