GapMind for Amino acid biosynthesis

 

Clusters of Characterized Proteins

Clustering the characterized proteins for aroB (3-dehydroquinate synthase) in chorismate biosynthesis

Or see other characterized proteins similar to aroB

Or see all steps for chorismate biosynthesis

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Definition of aroB

Fetched 10 sequences

Running BLASTp

Found similarities, at above 30% identity and 75% coverage, for 10 of these sequences

Found 2 clusters of similar sequences. Download as table or as draft rules or view by organism

Cluster 1 335-445 amino acids (not heteromeric)

AROB_HELPY / P56081 3-dehydroquinate synthase; DHQS; EC 4.2.3.4 from Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
PFams: Fe-ADH_2, DHQ_synthase
343 amino acids: PaperBLAST, CDD, Compare to cluster

C6WFL3 2-epi-valiolone synthase (EC 4.2.3.155) (from HMM only) from Actinosynnema mirum (strain ATCC 29888 / DSM 43827 / JCM 3225 / NBRC 14064 / NCIMB 13271 / NRRL B-12336 / IMRU 3971 / 101)
EVS_ACTMD / C6WFL3 2-epi-valiolone synthase; EVS; Sedoheptulose 7-phosphate cyclase; EC 4.2.3.155 from Actinosynnema mirum (strain ATCC 29888 / DSM 43827 / JCM 3225 / NBRC 14064 / NCIMB 13271 / NRRL B-12336 / IMRU 3971 / 101)
C6WFL3 2-epi-valiolone synthase (EC 4.2.3.155) from Actinosynnema mirum
PFams: Fe-ADH_2, DHQ_synthase
382 amino acids: PaperBLAST, CDD, Compare to cluster

b3389 3-dehydroquinate synthase (EC 4.2.3.4) from Escherichia coli K-12 substr. MG1655
P07639 3-dehydroquinate synthase (EC 4.2.3.4) from Escherichia coli (strain K12)
AROB_ECOLI / P07639 3-dehydroquinate synthase; DHQS; EC 4.2.3.4 from Escherichia coli (strain K12)
P07639 3-dehydroquinate synthase (EC 4.2.3.4) from Escherichia coli
PFams: Fe-ADH_2, Fe-ADH, DHQ_synthase
362 amino acids: PaperBLAST, CDD, Compare to cluster

P9WPX9 3-dehydroquinate synthase (EC 4.2.3.4) from Mycobacterium tuberculosis
PFams: Fe-ADH, Fe-ADH_2, DHQ_synthase
362 amino acids: PaperBLAST, CDD, Compare to cluster

Q3M4V2 3-dehydroquinate synthase (EC 4.2.3.4) from Trichormus variabilis
PFams: Fe-ADH_2, Fe-ADH, DHQ_synthase
363 amino acids: PaperBLAST, CDD, Compare to cluster

Q8U0A8 3-dehydroquinate synthase (EC 4.2.3.4) from Pyrococcus furiosus
PFams: DHQ_synthase
335 amino acids: PaperBLAST, CDD, Compare to cluster

DHQS_SOLLC / Q8RU74 3-dehydroquinate synthase, chloroplastic; EC 4.2.3.4 from Solanum lycopersicum (Tomato) (Lycopersicon esculentum)
PFams: Fe-ADH, Fe-ADH_2, DHQ_synthase
442 amino acids: PaperBLAST, CDD, Compare to cluster

DHQS_ACTCC / U3KRF2 3-dehydroquinate synthase, chloroplastic; EC 4.2.3.4 from Actinidia chinensis var. chinensis (Chinese soft-hair kiwi)
PFams: Fe-ADH, Fe-ADH_2, DHQ_synthase
445 amino acids: PaperBLAST, CDD, Compare to cluster

Cluster 2 1583-1588 amino acids (not heteromeric)

ARO1_EMENI / P07547 Pentafunctional AROM polypeptide; EC 4.2.3.4; EC 2.5.1.19; EC 2.7.1.71; EC 4.2.1.10; EC 1.1.1.25 from Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
P07547 shikimate dehydrogenase (NADP+) (EC 1.1.1.25) from Aspergillus nidulans
CH_122161 pentafunctional AROM polypeptide; EC 1.1.1.25; EC 2.5.1.19; EC 2.7.1.71; EC 4.2.1.10; EC 4.2.3.4 from Emericella nidulans
PFams: DHQ_synthase, Fe-ADH_2, EPSP_synthase, SKI, DHquinase_I, Shikimate_dh_N, SDH_C
1583 amino acids: PaperBLAST, CDD, Compare to cluster

P08566 pentafunctional AROM polypeptide (EC 4.2.3.4; EC 1.1.1.25; EC 2.7.1.71; EC 2.5.1.19; EC 4.2.1.10) from Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
ARO1_YEAST / P08566 Pentafunctional AROM polypeptide; EC 4.2.3.4; EC 2.5.1.19; EC 2.7.1.71; EC 4.2.1.10; EC 1.1.1.25 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
PFams: DHQ_synthase, EPSP_synthase, SKI, DHquinase_I, Shikimate_dh_N, Shikimate_DH, SDH_C
1588 amino acids: PaperBLAST, CDD, Compare to cluster