Clusters of Characterized Proteins

GapMind for Amino acid biosynthesis

Clusters of Characterized Proteins

Clustering the characterized proteins for aroD (3-dehydroquinate dehydratase) in chorismate biosynthesis

Or see other characterized proteins similar to aroD

Or see all steps for chorismate biosynthesis

Or cluster curated proteins matching a keyword

Definition of aroD

Curated proteins or TIGRFams with EC 4.2.1.10
Ignore hits to B9CK59 when looking for 'other' hits (3-dehydroquinate dehydratase (EC 4.2.1.10))
Ignore hits to items matching EC 1.1.1.24 when looking for 'other' hits
Ignore hits to items matching EC 1.1.1.25 when looking for 'other' hits
Ignore hits to items matching EC 1.1.1.282 when looking for 'other' hits
Predicted: UniProt sequence G0EDV3: RecName: Full=3-dehydroquinate dehydratase {ECO:0000256|ARBA:ARBA00012060}; EC=4.2.1.10 {ECO:0000256|ARBA:ARBA00012060};
Comment: B9CK59 may be misannotated in BRENDA. Several plant shikimate dehydrogenases may also be 3-dehydroquinate dehydratases (fusion proteins), so any similarity to shikimate dehydrogenase (EC 1.1.1.24 or 1.1.1.25 or 1.1.1.282) is ignored. PYRFU_RS04235 (G0EDV3) from Pyrolobus fumarii is diverged, especially at the C terminal part, but has conserved functional residues, and a homolog from Sedimentisphaera salicampi is fused to aroE, so it is probably the missing aroD.

Fetched 50 sequences

Running BLASTp

Found similarities, at above 30% identity and 75% coverage, for 49 of these sequences

Found 4 clusters of similar sequences. Another 2 sequences are not clustered. Download as table or as draft rules or view by organism

Cluster 1 142-173 amino acids (not heteromeric)

A0A0H3FM50 3-dehydroquinate dehydratase (EC 4.2.1.10) from Klebsiella aerogenes
PFams: DHquinase_II
150 amino acids: PaperBLAST, CDD, Compare to cluster

A0A124C1Y7 3-dehydroquinate dehydratase (EC 4.2.1.10) from Streptomyces acidiscabies
PFams: DHquinase_II
157 amino acids: PaperBLAST, CDD, Compare to cluster

A1SZA3 3-dehydroquinate dehydratase (EC 4.2.1.10) from Psychromonas ingrahamii
PFams: DHquinase_II
149 amino acids: PaperBLAST, CDD, Compare to cluster

A3M692 3-dehydroquinate dehydratase (EC 4.2.1.10) from Acinetobacter baumannii
PFams: DHquinase_II
151 amino acids: PaperBLAST, CDD, Compare to cluster

A5WDH9 3-dehydroquinate dehydratase (EC 4.2.1.10) from Psychrobacter sp. PRwf-1
PFams: DHquinase_II
167 amino acids: PaperBLAST, CDD, Compare to cluster

A8AQF2 3-dehydroquinate dehydratase (EC 4.2.1.10) from Citrobacter koseri
PFams: DHquinase_II
150 amino acids: PaperBLAST, CDD, Compare to cluster

B2A551 3-dehydroquinate dehydratase (EC 4.2.1.10) from Natranaerobius thermophilus
PFams: DHquinase_II
144 amino acids: PaperBLAST, CDD, Compare to cluster

D1A7X0 3-dehydroquinate dehydratase (EC 4.2.1.10) from Thermomonospora curvata
PFams: DHquinase_II
149 amino acids: PaperBLAST, CDD, Compare to cluster

D4LCT8 3-dehydroquinate dehydratase (EC 4.2.1.10) from Ruminococcus champanellensis
PFams: DHquinase_II
148 amino acids: PaperBLAST, CDD, Compare to cluster

D4S0D1 3-dehydroquinate dehydratase (EC 4.2.1.10) from Butyrivibrio crossotus
PFams: DHquinase_II
142 amino acids: PaperBLAST, CDD, Compare to cluster

E4RLB7 3-dehydroquinate dehydratase (EC 4.2.1.10) from Halanaerobium hydrogeniformans
PFams: DHquinase_II
148 amino acids: PaperBLAST, CDD, Compare to cluster

G8M0G7 3-dehydroquinate dehydratase (EC 4.2.1.10) from Acetivibrio clariflavus
PFams: DHquinase_II
142 amino acids: PaperBLAST, CDD, Compare to cluster

I0L192 3-dehydroquinate dehydratase (EC 4.2.1.10) from Micromonospora lupini
PFams: DHquinase_II
143 amino acids: PaperBLAST, CDD, Compare to cluster

M1E6S9 3-dehydroquinate dehydratase (EC 4.2.1.10) from Thermodesulfobium narugense
PFams: DHquinase_II
150 amino acids: PaperBLAST, CDD, Compare to cluster

N1V364 3-dehydroquinate dehydratase (EC 4.2.1.10) from Arthrobacter crystallopoietes
PFams: DHquinase_II
155 amino acids: PaperBLAST, CDD, Compare to cluster

O30557 3-dehydroquinate dehydratase (EC 4.2.1.10) from Pseudomonas aeruginosa
PFams: DHquinase_II
147 amino acids: PaperBLAST, CDD, Compare to cluster

O52377 3-dehydroquinate dehydratase (EC 4.2.1.10) from Corynebacterium glutamicum
PFams: DHquinase_II
145 amino acids: PaperBLAST, CDD, Compare to cluster

AROQ_STRCO / P15474 3-dehydroquinate dehydratase; 3-dehydroquinase; Type II DHQase; EC 4.2.1.10 from Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)
P15474 3-dehydroquinate dehydratase (EC 4.2.1.10) from Streptomyces coelicolor
PFams: DHquinase_II
157 amino acids: PaperBLAST, CDD, Compare to cluster

AROQ_MYCTU / P9WPX7 3-dehydroquinate dehydratase; 3-dehydroquinase; Type II DHQase; EC 4.2.1.10 from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
P9WPX7 3-dehydroquinate dehydratase (EC 4.2.1.10) from Mycobacterium tuberculosis
PFams: DHquinase_II
147 amino acids: PaperBLAST, CDD, Compare to cluster

Q0VMZ2 3-dehydroquinate dehydratase (EC 4.2.1.10) from Alcanivorax borkumensis
PFams: DHquinase_II
160 amino acids: PaperBLAST, CDD, Compare to cluster

AROQ_HELPY / Q48255 3-dehydroquinate dehydratase; 3-dehydroquinase; Type II DHQase; EC 4.2.1.10 from Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Q48255 3-dehydroquinate dehydratase (EC 4.2.1.10) from Helicobacter pylori
PFams: DHquinase_II
167 amino acids: PaperBLAST, CDD, Compare to cluster

Q88IJ6 3-dehydroquinate dehydratase (EC 4.2.1.10) from Pseudomonas putida
PFams: DHquinase_II
145 amino acids: PaperBLAST, CDD, Compare to cluster

Q9PH97 3-dehydroquinate dehydratase (EC 4.2.1.10) from Xylella fastidiosa
PFams: DHquinase_II
148 amino acids: PaperBLAST, CDD, Compare to cluster

W6JLW3 3-dehydroquinate dehydratase (EC 4.2.1.10) from Gluconobacter oxydans
PFams: DHquinase_II
160 amino acids: PaperBLAST, CDD, Compare to cluster

3DHQ_EMENI / P05147 Catabolic 3-dehydroquinase; cDHQase; 3-dehydroquinate dehydratase; EC 4.2.1.10 from Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
GI|2404 catabolic 3-dehydroquinase from Emericella nidulans
PFams: DHquinase_II
153 amino acids: PaperBLAST, CDD, Compare to cluster

3DHQ_NEUCR / P05195 Catabolic 3-dehydroquinase; cDHQase; 3-dehydroquinate dehydratase; Quinic acid degradation cluster protein 2f; EC 4.2.1.10 from Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
PFams: DHquinase_II
173 amino acids: PaperBLAST, CDD, Compare to cluster

AROQ_ACTPL / P43877 3-dehydroquinate dehydratase; 3-dehydroquinase; Type II DHQase; EC 4.2.1.10 from Actinobacillus pleuropneumoniae (Haemophilus pleuropneumoniae)
PFams: DHquinase_II
154 amino acids: PaperBLAST, CDD, Compare to cluster

AROQ_BACSU / P54517 3-dehydroquinate dehydratase; 3-dehydroquinase; Type II DHQase; EC 4.2.1.10 from Bacillus subtilis (strain 168)
P54517 3-dehydroquinate dehydratase (EC 4.2.1.10) from Bacillus subtilis
PFams: DHquinase_II
148 amino acids: PaperBLAST, CDD, Compare to cluster

3DHQ_CANAL / Q59Z17 Catabolic 3-dehydroquinase; cDHQase; 3-dehydroquinate dehydratase; EC 4.2.1.10 from Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
PFams: DHquinase_II
146 amino acids: PaperBLAST, CDD, Compare to cluster

Q5FTS6 periplasmic dehydroquinate dehydratase (EC 4.2.1.10) from Gluconobacter oxydans (strain 621H)
PFams: DHquinase_II
160 amino acids: PaperBLAST, CDD, Compare to cluster

A4QB64 3-dehydroquinate dehydratase (EC 4.2.1.10) from Corynebacterium glutamicum (strain R)
PFams: DHquinase_II
145 amino acids: PaperBLAST, CDD, Compare to cluster

Cluster 2 218-272 amino acids (not heteromeric)

b1693 3-dehydroquinate dehydratase (EC 4.2.1.10) from Escherichia coli K-12 substr. MG1655
P05194 3-dehydroquinate dehydratase (EC 4.2.1.10) from Escherichia coli (strain K12)
AROD_ECOLI / P05194 3-dehydroquinate dehydratase; 3-dehydroquinase; Type I DHQase; Type I dehydroquinase; DHQ1; EC 4.2.1.10 from Escherichia coli (strain K12)
P05194 3-dehydroquinate dehydratase (EC 4.2.1.10) from Escherichia coli
RF|NP_416208.1 3-dehydroquinate dehydratase; EC 4.2.1.10 from Escherichia coli K12
PFams: DHquinase_I
252 amino acids: PaperBLAST, CDD, Compare to cluster

AROD_SALTI / P24670 3-dehydroquinate dehydratase; 3-dehydroquinase; Type I DHQase; Type I dehydroquinase; DHQ1; EC 4.2.1.10 from Salmonella typhi
P24670 3-dehydroquinate dehydratase (EC 4.2.1.10) from Salmonella enterica subsp. enterica serovar Typhi
PFams: DHquinase_I
252 amino acids: PaperBLAST, CDD, Compare to cluster

AROD_ENTFA / P36923 3-dehydroquinate dehydratase; 3-dehydroquinase; Type I DHQase; Type I dehydroquinase; DHQ1; EC 4.2.1.10 from Enterococcus faecalis (strain ATCC 700802 / V583)
P36923 3-dehydroquinate dehydratase (EC 4.2.1.10) from Enterococcus faecalis
PFams: DHquinase_I
253 amino acids: PaperBLAST, CDD, Compare to cluster

AROD_SALTY / P58687 3-dehydroquinate dehydratase; 3-dehydroquinase; DHQD; Type I DHQase; Type I dehydroquinase; DHQ1; EC 4.2.1.10 from Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
P58687 3-dehydroquinate dehydratase (EC 4.2.1.10) from Salmonella enterica
PFams: DHquinase_I
252 amino acids: PaperBLAST, CDD, Compare to cluster

AROD_AQUAE / O66440 3-dehydroquinate dehydratase; 3-dehydroquinase; Type I DHQase; Type I dehydroquinase; DHQ1; EC 4.2.1.10 from Aquifex aeolicus (strain VF5)
PFams: DHquinase_I
219 amino acids: PaperBLAST, CDD, Compare to cluster

AROD_CLOD6 / Q186A6 3-dehydroquinate dehydratase; 3-dehydroquinase; Type I DHQase; Type I dehydroquinase; DHQ1; EC 4.2.1.10 from Clostridioides difficile (strain 630) (Peptoclostridium difficile)
PFams: DHquinase_I
255 amino acids: PaperBLAST, CDD, Compare to cluster

Q59087 catabolic 3-dehydroquinate dehydratase (EC 4.2.1.10) from Acinetobacter baylyi (strain ATCC 33305 / BD413 / ADP1)
3DHQ_ACIAD / Q59087 Catabolic 3-dehydroquinate dehydratase; 3-dehydroquinase; EC 4.2.1.10 from Acinetobacter baylyi (strain ATCC 33305 / BD413 / ADP1)
PFams: DHquinase_I
272 amino acids: PaperBLAST, CDD, Compare to cluster

AROD_GEOKA / Q5KY94 3-dehydroquinate dehydratase; 3-dehydroquinase; Type I DHQase; Type I dehydroquinase; DHQ1; EC 4.2.1.10 from Geobacillus kaustophilus (strain HTA426)
PFams: DHquinase_I
257 amino acids: PaperBLAST, CDD, Compare to cluster

AROD_STAAR / Q6GII7 3-dehydroquinate dehydratase; 3-dehydroquinase; Type I DHQase; Type I dehydroquinase; DHQ1; EC 4.2.1.10 from Staphylococcus aureus (strain MRSA252)
PFams: DHquinase_I
238 amino acids: PaperBLAST, CDD, Compare to cluster

Q6LXF7 3-dehydroquinate dehydratase (EC 4.2.1.10) from Methanococcus maripaludis (strain S2 / LL)
AROD_METMP / Q6LXF7 3-dehydroquinate dehydratase; 3-dehydroquinase; Type I DHQase; Type I dehydroquinase; DHQ1; EC 4.2.1.10 from Methanococcus maripaludis (strain S2 / LL)
PFams: DHquinase_I
218 amino acids: PaperBLAST, CDD, Compare to cluster

Cluster 3 521-603 amino acids (not heteromeric)

A0A5H2WZU5 shikimate dehydrogenase (NADP+) (EC 1.1.1.25); 3-dehydroquinate dehydratase (EC 4.2.1.10) from Eucalyptus camaldulensis
PFams: DHquinase_I, Shikimate_dh_N, Shikimate_DH, F420_oxidored, SDH_C
532 amino acids: PaperBLAST, CDD, Compare to cluster

A0A5H2X4C4 shikimate dehydrogenase (NADP+) (EC 1.1.1.25); 3-dehydroquinate dehydratase (EC 4.2.1.10) from Eucalyptus camaldulensis
PFams: DHquinase_I, Shikimate_dh_N, Shikimate_DH, F420_oxidored, SDH_C
538 amino acids: PaperBLAST, CDD, Compare to cluster

Q6PUF9 shikimate dehydrogenase (NADP+) (EC 1.1.1.25); 3-dehydroquinate dehydratase (EC 4.2.1.10) from Nicotiana tabacum
PFams: DHquinase_I, Shikimate_dh_N, Shikimate_DH, F420_oxidored
569 amino acids: PaperBLAST, CDD, Compare to cluster

Q6PUG0 shikimate dehydrogenase (NADP+) (EC 1.1.1.25); 3-dehydroquinate dehydratase (EC 4.2.1.10) from Nicotiana tabacum
PFams: DHquinase_I, Shikimate_dh_N
521 amino acids: PaperBLAST, CDD, Compare to cluster

Q9SQT8 shikimate dehydrogenase (EC 1.1.1.25; EC 4.2.1.10) from Arabidopsis thaliana
DHQSD_ARATH / Q9SQT8 Bifunctional 3-dehydroquinate dehydratase/shikimate dehydrogenase, chloroplastic; DHQ-SDH protein; DHQase-SORase; Protein EMBRYO DEFECTIVE 3004; EC 4.2.1.10; EC 1.1.1.25 from Arabidopsis thaliana (Mouse-ear cress)
Q9SQT8 shikimate dehydrogenase (NADP+) (EC 1.1.1.25); 3-dehydroquinate dehydratase (EC 4.2.1.10) from Arabidopsis thaliana
PFams: DHquinase_I, Shikimate_dh_N, Shikimate_DH, IlvN, F420_oxidored, FAD_binding_2, SDH_C
603 amino acids: PaperBLAST, CDD, Compare to cluster

Cluster 4 1583-1588 amino acids (not heteromeric)

ARO1_EMENI / P07547 Pentafunctional AROM polypeptide; EC 4.2.3.4; EC 2.5.1.19; EC 2.7.1.71; EC 4.2.1.10; EC 1.1.1.25 from Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
P07547 shikimate dehydrogenase (NADP+) (EC 1.1.1.25) from Aspergillus nidulans
CH_122161 pentafunctional AROM polypeptide; EC 1.1.1.25; EC 2.5.1.19; EC 2.7.1.71; EC 4.2.1.10; EC 4.2.3.4 from Emericella nidulans
PFams: DHQ_synthase, Fe-ADH_2, EPSP_synthase, SKI, DHquinase_I, Shikimate_dh_N, SDH_C
1583 amino acids: PaperBLAST, CDD, Compare to cluster

P08566 pentafunctional AROM polypeptide (EC 4.2.3.4; EC 1.1.1.25; EC 2.7.1.71; EC 2.5.1.19; EC 4.2.1.10) from Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
ARO1_YEAST / P08566 Pentafunctional AROM polypeptide; EC 4.2.3.4; EC 2.5.1.19; EC 2.7.1.71; EC 4.2.1.10; EC 1.1.1.25 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
PFams: DHQ_synthase, EPSP_synthase, SKI, DHquinase_I, Shikimate_dh_N, Shikimate_DH, SDH_C
1588 amino acids: PaperBLAST, CDD, Compare to cluster

Singletons (0/2 heteromeric)

AROD_ARCFU / O30011 3-dehydroquinate dehydratase; 3-dehydroquinase; Type I DHQase; Type I dehydroquinase; DHQ1; EC 4.2.1.10 from Archaeoglobus fulgidus (strain ATCC 49558 / DSM 4304 / JCM 9628 / NBRC 100126 / VC-16)
O30011 3-dehydroquinate dehydratase (EC 4.2.1.10) from Archaeoglobus fulgidus
PFams: DHquinase_I
196 amino acids: PaperBLAST, CDD
(similar to SwissProt::O66440 from Cluster 2, but similarity to seed sequence is below thresholds)

G0EDV3 3-dehydroquinate dehydratase; EC=4.2.1.10
240 amino acids: PaperBLAST, CDD