Clusters of Characterized Proteins

GapMind for Amino acid biosynthesis

Clusters of Characterized Proteins

Clustering the characterized proteins for aroE (shikimate dehydrogenase) in chorismate biosynthesis

Or see other characterized proteins similar to aroE

Or see all steps for chorismate biosynthesis

Or cluster curated proteins matching a keyword

Definition of aroE

Curated proteins or TIGRFams with EC 1.1.1.25
Curated proteins or TIGRFams with EC 1.1.1.282
UniProt sequence Q8A006_BACTN: SubName: Full=Shikimate 5-dehydrogenase {ECO:0000313|EMBL:AAO79320.1};
UniProt sequence A0A2M8WD96: RecName: Full=Shikimate dehydrogenase (NADP(+)) {ECO:0000256|HAMAP-Rule:MF_00222}; Short=SDH {ECO:0000256|HAMAP-Rule:MF_00222}; EC=1.1.1.25 {ECO:0000256|HAMAP-Rule:MF_00222};
Ignore hits to CH_122204 when looking for 'other' hits (quinate dehydrogenase; EC 1.1.1.24. quinate dehydrogenase (EC 1.1.1.282))
Comment: EC 1.1.1.282 is with NAD(P)H instead of NADPH. BT4215 from Bacteroides thetaiotaomicron (Q8A006_BACTN) is diverged, is the only good candidate, and is essential in various Bacteroidetes. Ga0059261_2194 / BDW16_RS10815 (A0A2M8WD96) has auxotrophic phenotypes in RB-TnSeq data and can complement an aroE- strain of E. coli (Bradley Biggs). CH_122204 in CharProtDB is ignored because it is probably quinate dehydrogenase, not shikimate dehydrogenase.

Fetched 48 sequences

Running BLASTp

Found similarities, at above 30% identity and 75% coverage, for 47 of these sequences

Found 3 clusters of similar sequences. Another 2 sequences are not clustered. Download as table or as draft rules or view by organism

Cluster 1 247-291 amino acids (not heteromeric)

O27957 shikimate dehydrogenase (NADP+) (EC 1.1.1.25) from Archaeoglobus fulgidus
PFams: Shikimate_dh_N, Shikimate_DH, SDH_C
269 amino acids: PaperBLAST, CDD, Compare to cluster

A4QEK4 shikimate dehydrogenase (NADP+) (EC 1.1.1.25) from Corynebacterium glutamicum
PFams: Shikimate_dh_N, Shikimate_DH, SDH_C
276 amino acids: PaperBLAST, CDD, Compare to cluster

b1692 quinate/shikimate dehydrogenase (EC 1.1.1.282) from Escherichia coli K-12 substr. MG1655
P0A6D5 quinate/shikimate dehydrogenase (EC 1.1.1.282) from Escherichia coli (strain K12)
YDIB_ECOLI / P0A6D5 Quinate/shikimate dehydrogenase; NAD-dependent shikimate 5-dehydrogenase; EC 1.1.1.282 from Escherichia coli (strain K12)
P0A6D5 shikimate dehydrogenase (NADP+) (EC 1.1.1.25) from Escherichia coli
RF|NP_416207 quinate/shikimate dehydrogenase; EC 1.1.1.282 from Escherichia coli K12
PFams: Shikimate_dh_N, SDH_C
288 amino acids: PaperBLAST, CDD, Compare to cluster

b3281 shikimate dehydrogenase (EC 1.1.1.25) from Escherichia coli K-12 substr. MG1655
P15770 shikimate dehydrogenase (EC 1.1.1.25) from Escherichia coli (strain K12)
AROE_ECOLI / P15770 Shikimate dehydrogenase (NADP(+)); SD; SDH; EC 1.1.1.25 from Escherichia coli (strain K12)
P15770 shikimate dehydrogenase (NADP+) (EC 1.1.1.25) from Escherichia coli
PFams: Shikimate_dh_N, Shikimate_DH, SDH_C
272 amino acids: PaperBLAST, CDD, Compare to cluster

AROE_HAEIN / P43876 Shikimate dehydrogenase (NADP(+)); SDH; EC 1.1.1.25 from Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
P43876 shikimate dehydrogenase (NADP+) (EC 1.1.1.25) from Haemophilus influenzae
PFams: Shikimate_dh_N, Shikimate_DH, SDH_C
272 amino acids: PaperBLAST, CDD, Compare to cluster

AROE_THET8 / Q5SJF8 Shikimate dehydrogenase (NADP(+)); SDH; EC 1.1.1.25 from Thermus thermophilus (strain ATCC 27634 / DSM 579 / HB8)
Q5SJF8 shikimate dehydrogenase (NADP+) (EC 1.1.1.25) from Thermus thermophilus
PFams: Shikimate_dh_N, Shikimate_DH, F420_oxidored, SDH_C
263 amino acids: PaperBLAST, CDD, Compare to cluster

Q88GF6 shikimate dehydrogenase (NADP+) (EC 1.1.1.25); quinate/shikimate dehydrogenase [NAD(P)+] (EC 1.1.1.282) from Pseudomonas putida
PFams: Shikimate_dh_N
273 amino acids: PaperBLAST, CDD, Compare to cluster

Q88IJ7 shikimate dehydrogenase (NADP+) (EC 1.1.1.25) from Pseudomonas putida KT2440
PFams: Shikimate_dh_N, Shikimate_DH, SDH_C
272 amino acids: PaperBLAST, CDD, Compare to cluster

Q88JP1 shikimate dehydrogenase (NADP+) (EC 1.1.1.25); quinate/shikimate dehydrogenase [NAD(P)+] (EC 1.1.1.282) from Pseudomonas putida
PFams: Shikimate_dh_N, ThiF
269 amino acids: PaperBLAST, CDD, Compare to cluster

Q88K85 shikimate dehydrogenase (NADP+) (EC 1.1.1.25); quinate/shikimate dehydrogenase [NAD(P)+] (EC 1.1.1.282) from Pseudomonas putida
PFams: Shikimate_dh_N, SDH_C
282 amino acids: PaperBLAST, CDD, Compare to cluster

Q88RQ5 shikimate dehydrogenase (NADP+) (EC 1.1.1.25) from Pseudomonas putida
PFams: Shikimate_dh_N, Shikimate_DH, SDH_C
274 amino acids: PaperBLAST, CDD, Compare to cluster

Q9WYI1 shikimate dehydrogenase (NADP+) (EC 1.1.1.25) from Thermotoga maritima
PFams: Shikimate_dh_N, Shikimate_DH
253 amino acids: PaperBLAST, CDD, Compare to cluster

Q9X5C9 quinate/shikimate dehydrogenase monomer (EC 1.1.1.24) from Corynebacterium glutamicum (strain ATCC 13032 / DSM 20300 / BCRC 11384 / JCM 1318 / LMG 3730 / NCIMB 10025)
AROE_CORGL / Q9X5C9 Quinate/shikimate dehydrogenase (NAD(+)); QSDH; EC 1.1.1.-; EC 1.1.1.24 from Corynebacterium glutamicum (strain ATCC 13032 / DSM 20300 / BCRC 11384 / JCM 1318 / LMG 3730 / NCIMB 10025)
Q9X5C9 quinate/shikimate dehydrogenase [NAD(P)+] (EC 1.1.1.282) from Corynebacterium glutamicum
PFams: Shikimate_dh_N, SDH_C
283 amino acids: PaperBLAST, CDD, Compare to cluster

AROE_CORGB / A4QB65 Quinate/shikimate dehydrogenase (NAD(+)); QSDH; EC 1.1.1.-; EC 1.1.1.24 from Corynebacterium glutamicum (strain R)
A4QB65 shikimate dehydrogenase (NADP+) (EC 1.1.1.25); quinate/shikimate dehydrogenase [NAD(P)+] (EC 1.1.1.282) from Corynebacterium glutamicum
PFams: Shikimate_dh_N, SDH_C
283 amino acids: PaperBLAST, CDD, Compare to cluster

AROE_AQUAE / O67049 Shikimate dehydrogenase (NADP(+)); SD; SDH; EC 1.1.1.25 from Aquifex aeolicus (strain VF5)
O67049 shikimate dehydrogenase (NADP+) (EC 1.1.1.25) from Aquifex aeolicus
PFams: Shikimate_dh_N, Shikimate_DH, F420_oxidored, NAD_binding_2, SDH_C
269 amino acids: PaperBLAST, CDD, Compare to cluster

SHDHL_HAEIN / P44774 Shikimate dehydrogenase-like protein HI_0607; SDH-L; EC 1.1.1.25 from Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
PFams: Shikimate_dh_N
271 amino acids: PaperBLAST, CDD, Compare to cluster

AROE_HELPY / P56119 Shikimate dehydrogenase (NADP(+)); SDH; EC 1.1.1.25 from Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
PFams: Shikimate_dh_N
263 amino acids: PaperBLAST, CDD, Compare to cluster

AROE_HELPX / Q56S04 Shikimate dehydrogenase (NADP(+)); SDH; EC 1.1.1.25 from Helicobacter pylori (Campylobacter pylori)
Q56S04 shikimate dehydrogenase (NADP+) (EC 1.1.1.25) from Helicobacter pylori
PFams: Shikimate_dh_N
263 amino acids: PaperBLAST, CDD, Compare to cluster

Q58484 shikimate dehydrogenase monomer (EC 1.1.1.25) from Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440)
AROE_METJA / Q58484 Shikimate dehydrogenase (NADP(+)); SDH; EC 1.1.1.25 from Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii)
PFams: Shikimate_dh_N, Shikimate_DH, SDH_C
282 amino acids: PaperBLAST, CDD, Compare to cluster

AROE_STAEQ / Q5HNV1 Shikimate dehydrogenase (NADP(+)); SDH; EC 1.1.1.25 from Staphylococcus epidermidis (strain ATCC 35984 / RP62A)
Q5HNV1 shikimate dehydrogenase (NADP+) (EC 1.1.1.25) from Staphylococcus epidermidis
PFams: Shikimate_dh_N, Shikimate_DH, SDH_C
269 amino acids: PaperBLAST, CDD, Compare to cluster

AROE_GEOKA / Q5KWX7 Shikimate dehydrogenase (NADP(+)); SDH; EC 1.1.1.25 from Geobacillus kaustophilus (strain HTA426)
PFams: Shikimate_dh_N, Shikimate_DH, SDH_C
276 amino acids: PaperBLAST, CDD, Compare to cluster

AROE_LISMO / Q8Y9N5 Shikimate dehydrogenase (NADP(+)); SDH; EC 1.1.1.25 from Listeria monocytogenes serovar 1/2a (strain ATCC BAA-679 / EGD-e)
PFams: Shikimate_dh_N, SDH_C
291 amino acids: PaperBLAST, CDD, Compare to cluster

AROE_VIBCH / Q9KVT3 Shikimate dehydrogenase (NADP(+)); SDH; EC 1.1.1.25 from Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961)
PFams: Shikimate_dh_N, Shikimate_DH, SDH_C
278 amino acids: PaperBLAST, CDD, Compare to cluster

A0A2M8WD96 Shikimate dehydrogenase (NADP(+)) {ECO:0000256|HAMAP-Rule:MF_00222}; Short=SDH {ECO:0000256|HAMAP-Rule:MF_00222}; EC=1.1.1.25 {ECO:0000256|HAMAP-Rule:MF_00222}
270 amino acids: PaperBLAST, CDD, Compare to cluster

Q8A006_BACTN Shikimate 5-dehydrogenase
248 amino acids: PaperBLAST, CDD, Compare to cluster

A0A095ULP3 5-ketofructose reductase (NADP) monomer (EC 1.1.1.124) (from HMM only) from Tatumella morbirosei
PFams: Shikimate_dh_N, Shikimate_DH, SDH_C
284 amino acids: PaperBLAST, CDD, Compare to cluster

BT4215 shikimate dehydrogenase (EC 1.1.1.25) from Bacteroides thetaiotaomicron VPI-5482
PFams: Shikimate_dh_N
248 amino acids: PaperBLAST, CDD, Compare to cluster

CCNA_00003 shikimate dehydrogenase (EC 1.1.1.25) from Caulobacter crescentus NA1000
PFams: Shikimate_dh_N, Shikimate_DH
285 amino acids: PaperBLAST, CDD, Compare to cluster

CA265_RS19745 shikimate dehydrogenase (EC 1.1.1.25) from Pedobacter sp. GW460-11-11-14-LB5
PFams: Shikimate_dh_N
247 amino acids: PaperBLAST, CDD, Compare to cluster

Cluster 2 514-603 amino acids (not heteromeric)

A0A0A0LQ48 shikimate dehydrogenase (NADP+) (EC 1.1.1.25) from Cucumis sativus
PFams: DHquinase_I, Shikimate_dh_N, Shikimate_DH, F420_oxidored, SDH_C
542 amino acids: PaperBLAST, CDD, Compare to cluster

A0A168S2B8 shikimate dehydrogenase (NADP+) (EC 1.1.1.25) from Vitis vinifera
PFams: DHquinase_I, Shikimate_dh_N, Shikimate_DH, F420_oxidored, SDH_C
519 amino acids: PaperBLAST, CDD, Compare to cluster

A0A168S2G5 shikimate dehydrogenase (NADP+) (EC 1.1.1.25) from Vitis vinifera
PFams: DHquinase_I, Shikimate_dh_N, Shikimate_DH, F420_oxidored, SDH_C
531 amino acids: PaperBLAST, CDD, Compare to cluster

A0A168S2H6 shikimate dehydrogenase (NADP+) (EC 1.1.1.25) from Vitis vinifera
PFams: DHquinase_I, Shikimate_dh_N, Shikimate_DH, F420_oxidored, SDH_C
531 amino acids: PaperBLAST, CDD, Compare to cluster

A0A3G3BK08 shikimate dehydrogenase (NADP+) (EC 1.1.1.25) from Camellia sinensis
PFams: DHquinase_I, Shikimate_dh_N, SDH_C
519 amino acids: PaperBLAST, CDD, Compare to cluster

A0A3Q7H2B2 quinate/shikimate dehydrogenase [NAD(P)+] (EC 1.1.1.282) from Solanum lycopersicum
PFams: DHquinase_I, Shikimate_dh_N, Shikimate_DH, SDH_C
568 amino acids: PaperBLAST, CDD, Compare to cluster

A0A3Q7IET9 quinate/shikimate dehydrogenase [NAD(P)+] (EC 1.1.1.282) from Solanum lycopersicum
PFams: DHquinase_I, Shikimate_dh_N, SDH_C
514 amino acids: PaperBLAST, CDD, Compare to cluster

A0A5H2WVH6 shikimate dehydrogenase (NADP+) (EC 1.1.1.25) from Eucalyptus camaldulensis
PFams: DHquinase_I, Shikimate_dh_N, Shikimate_DH, F420_oxidored, SDH_C
530 amino acids: PaperBLAST, CDD, Compare to cluster

A0A5H2WZU5 shikimate dehydrogenase (NADP+) (EC 1.1.1.25); 3-dehydroquinate dehydratase (EC 4.2.1.10) from Eucalyptus camaldulensis
PFams: DHquinase_I, Shikimate_dh_N, Shikimate_DH, F420_oxidored, SDH_C
532 amino acids: PaperBLAST, CDD, Compare to cluster

A0A5H2X4C4 shikimate dehydrogenase (NADP+) (EC 1.1.1.25); 3-dehydroquinate dehydratase (EC 4.2.1.10) from Eucalyptus camaldulensis
PFams: DHquinase_I, Shikimate_dh_N, Shikimate_DH, F420_oxidored, SDH_C
538 amino acids: PaperBLAST, CDD, Compare to cluster

A0A6P8EJ47 shikimate dehydrogenase (NADP+) (EC 1.1.1.25) from Punica granatum
PFams: DHquinase_I, Shikimate_dh_N, Shikimate_DH, F420_oxidored, Sacchrp_dh_NADP, SDH_C
545 amino acids: PaperBLAST, CDD, Compare to cluster

D7TUX1 shikimate dehydrogenase (NADP+) (EC 1.1.1.25) from Vitis vinifera
PFams: DHquinase_I, Shikimate_dh_N, SDH_C
519 amino acids: PaperBLAST, CDD, Compare to cluster

Q6PUF9 shikimate dehydrogenase (NADP+) (EC 1.1.1.25); 3-dehydroquinate dehydratase (EC 4.2.1.10) from Nicotiana tabacum
PFams: DHquinase_I, Shikimate_dh_N, Shikimate_DH, F420_oxidored
569 amino acids: PaperBLAST, CDD, Compare to cluster

Q6PUG0 shikimate dehydrogenase (NADP+) (EC 1.1.1.25); 3-dehydroquinate dehydratase (EC 4.2.1.10) from Nicotiana tabacum
PFams: DHquinase_I, Shikimate_dh_N
521 amino acids: PaperBLAST, CDD, Compare to cluster

Q9SQT8 shikimate dehydrogenase (EC 1.1.1.25; EC 4.2.1.10) from Arabidopsis thaliana
DHQSD_ARATH / Q9SQT8 Bifunctional 3-dehydroquinate dehydratase/shikimate dehydrogenase, chloroplastic; DHQ-SDH protein; DHQase-SORase; Protein EMBRYO DEFECTIVE 3004; EC 4.2.1.10; EC 1.1.1.25 from Arabidopsis thaliana (Mouse-ear cress)
Q9SQT8 shikimate dehydrogenase (NADP+) (EC 1.1.1.25); 3-dehydroquinate dehydratase (EC 4.2.1.10) from Arabidopsis thaliana
PFams: DHquinase_I, Shikimate_dh_N, Shikimate_DH, IlvN, F420_oxidored, FAD_binding_2, SDH_C
603 amino acids: PaperBLAST, CDD, Compare to cluster

Cluster 3 1583-1588 amino acids (not heteromeric)

ARO1_EMENI / P07547 Pentafunctional AROM polypeptide; EC 4.2.3.4; EC 2.5.1.19; EC 2.7.1.71; EC 4.2.1.10; EC 1.1.1.25 from Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
P07547 shikimate dehydrogenase (NADP+) (EC 1.1.1.25) from Aspergillus nidulans
CH_122161 pentafunctional AROM polypeptide; EC 1.1.1.25; EC 2.5.1.19; EC 2.7.1.71; EC 4.2.1.10; EC 4.2.3.4 from Emericella nidulans
PFams: DHQ_synthase, Fe-ADH_2, EPSP_synthase, SKI, DHquinase_I, Shikimate_dh_N, SDH_C
1583 amino acids: PaperBLAST, CDD, Compare to cluster

P08566 pentafunctional AROM polypeptide (EC 4.2.3.4; EC 1.1.1.25; EC 2.7.1.71; EC 2.5.1.19; EC 4.2.1.10) from Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
ARO1_YEAST / P08566 Pentafunctional AROM polypeptide; EC 4.2.3.4; EC 2.5.1.19; EC 2.7.1.71; EC 4.2.1.10; EC 1.1.1.25 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
PFams: DHQ_synthase, EPSP_synthase, SKI, DHquinase_I, Shikimate_dh_N, Shikimate_DH, SDH_C
1588 amino acids: PaperBLAST, CDD, Compare to cluster

Singletons (0/2 heteromeric)

A0A045GU47 shikimate dehydrogenase (NADP+) (EC 1.1.1.25) from Mycobacterium tuberculosis
A5U5Q2 shikimate dehydrogenase (NADP+) (EC 1.1.1.25) from Mycobacterium tuberculosis
P95001 shikimate dehydrogenase (NADP+) (EC 1.1.1.25) from Mycobacterium tuberculosis
PFams: Shikimate_dh_N, SDH_C
269 amino acids: PaperBLAST, CDD
(similar to BRENDA::A4QEK4 from Cluster 1, but similarity to seed sequence is below thresholds)

Q6W3D0 shikimate dehydrogenase (NADP+) (EC 1.1.1.25) from Toxoplasma gondii
PFams: DHQ_synthase, DHQ_synthase, EPSP_synthase, EPSP_synthase, SKI, DHquinase_I, Shikimate_dh_N
3332 amino acids: PaperBLAST, CDD