Clusters of Characterized Proteins

GapMind for Amino acid biosynthesis

Clusters of Characterized Proteins

Clustering the characterized proteins for tpiA (D-glyceraldehyde-3-phosphate phospholyase) in chorismate biosynthesis

Or see other characterized proteins similar to tpiA

Or see all steps for chorismate biosynthesis

Or cluster curated proteins matching a keyword

Definition of tpiA

Curated proteins or TIGRFams with EC 5.3.1.1
Ignore hits to P00941 when looking for 'other' hits (purine-nucleoside phosphorylase (EC 2.4.2.1))
Comment: The triose-phosphate isomerase tpiA is also thought to convert D-glyceraldehyde 3-phosphate to enolaldehyde, which spontaneously converts to methylglyoxal. (Alternatively, methylglyoxal might be formed by methylgyoxal synthase, EC 4.2.3.3?) Ignore P00941, which is misannotated in BRENDA.

Fetched 58 sequences

Running BLASTp

Found similarities, at above 30% identity and 75% coverage, for 56 of these sequences

Found 2 clusters of similar sequences. Another 2 sequences are not clustered. Download as table or as draft rules or view by organism

Cluster 1 232-282 amino acids (not heteromeric)

A8B3A8 triose-phosphate isomerase (EC 5.3.1.1) from Rhipicephalus microplus
PFams: TIM
249 amino acids: PaperBLAST, CDD, Compare to cluster

A0A1D3TX75 triose-phosphate isomerase (EC 5.3.1.1) from Anaerobium acetethylicum
PFams: TIM
262 amino acids: PaperBLAST, CDD, Compare to cluster

A2EGX9 triose-phosphate isomerase (EC 5.3.1.1) from Trichomonas vaginalis
PFams: TIM
252 amino acids: PaperBLAST, CDD, Compare to cluster

A2FT29 triose-phosphate isomerase (EC 5.3.1.1) from Trichomonas vaginalis
PFams: TIM
252 amino acids: PaperBLAST, CDD, Compare to cluster

TPIS_ENTH1 / O02611 Triosephosphate isomerase; EhTIM; Triose-phosphate isomerase; EC 5.3.1.1 from Entamoeba histolytica (strain ATCC 30459 / HM-1:IMSS / ABRM)
O02611 triose-phosphate isomerase (EC 5.3.1.1) from Entamoeba histolytica
PFams: TIM
261 amino acids: PaperBLAST, CDD, Compare to cluster

TPIS_RABIT / P00939 Triosephosphate isomerase; TIM; Methylglyoxal synthase; Triose-phosphate isomerase; EC 5.3.1.1; EC 4.2.3.3 from Oryctolagus cuniculus (Rabbit)
P00939 triose-phosphate isomerase (EC 5.3.1.1) from Oryctolagus cuniculus
PFams: TIM
249 amino acids: PaperBLAST, CDD, Compare to cluster

TPIS_CHICK / P00940 Triosephosphate isomerase; TIM; Methylglyoxal synthase; Triose-phosphate isomerase; EC 5.3.1.1; EC 4.2.3.3 from Gallus gallus (Chicken)
P00940 triose-phosphate isomerase (EC 5.3.1.1) from Gallus gallus
PFams: TIM
248 amino acids: PaperBLAST, CDD, Compare to cluster

TPIS_YEAST / P00942 Triosephosphate isomerase; TIM; Triose-phosphate isomerase; EC 5.3.1.1 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
P00942 triose-phosphate isomerase (EC 5.3.1.1) from Saccharomyces cerevisiae
PFams: TIM
248 amino acids: PaperBLAST, CDD, Compare to cluster

TPIS_GEOSE / P00943 Triosephosphate isomerase; TIM; TPI; Triose-phosphate isomerase; EC 5.3.1.1 from Geobacillus stearothermophilus (Bacillus stearothermophilus)
P00943 triose-phosphate isomerase (EC 5.3.1.1) from Geobacillus stearothermophilus
PFams: TIM
253 amino acids: PaperBLAST, CDD, Compare to cluster

b3919 triose-phosphate isomerase (EC 5.3.1.1) from Escherichia coli K-12 substr. MG1655
P0A858 triose-phosphate isomerase (EC 5.3.1.1) from Escherichia coli (strain K12)
TPIS_ECODH / B1XB85 Triosephosphate isomerase; TIM; TPI; Triose-phosphate isomerase; EC 5.3.1.1 from Escherichia coli (strain K12 / DH10B)
TPIS_ECOLI / P0A858 Triosephosphate isomerase; TIM; TPI; Triose-phosphate isomerase; EC 5.3.1.1 from Escherichia coli (strain K12)
P0A858 triose-phosphate isomerase (EC 5.3.1.1) from Escherichia coli
RF|NP_418354 triose-phosphate isomerase from Escherichia coli K12
PFams: TIM
255 amino acids: PaperBLAST, CDD, Compare to cluster

P35144 triose-phosphate isomerase (EC 5.3.1.1) from Priestia megaterium
PFams: TIM
251 amino acids: PaperBLAST, CDD, Compare to cluster

P36186 triose-phosphate isomerase (EC 5.3.1.1) from Giardia intestinalis
PFams: TIM
257 amino acids: PaperBLAST, CDD, Compare to cluster

P48491 cytosolic triose-phosphate isomerase (EC 5.3.1.1) from Arabidopsis thaliana
TPIS_ARATH / P48491 Triosephosphate isomerase, cytosolic; TIM; Triose-phosphate isomerase; EC 5.3.1.1 from Arabidopsis thaliana (Mouse-ear cress)
P48491 triose-phosphate isomerase (EC 5.3.1.1) from Arabidopsis thaliana
PFams: TIM
254 amino acids: PaperBLAST, CDD, Compare to cluster

P52270 triose-phosphate isomerase (EC 5.3.1.1) from Trypanosoma cruzi
PFams: TIM
251 amino acids: PaperBLAST, CDD, Compare to cluster

TPIS_HELPY / P56076 Triosephosphate isomerase; TIM; TPI; Triose-phosphate isomerase; EC 5.3.1.1 from Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
P56076 triose-phosphate isomerase (EC 5.3.1.1) from Helicobacter pylori
PFams: TIM
234 amino acids: PaperBLAST, CDD, Compare to cluster

P60174 Triosephosphate isomerase (EC 5.3.1.1) from Homo sapiens
TPIS_HUMAN / P60174 Triosephosphate isomerase; TIM; Methylglyoxal synthase; Triose-phosphate isomerase; EC 5.3.1.1; EC 4.2.3.3 from Homo sapiens (Human)
P60174 triose-phosphate isomerase (EC 5.3.1.1) from Homo sapiens
PFams: TIM
249 amino acids: PaperBLAST, CDD, Compare to cluster

TPIS_MYCTU / P9WG43 Triosephosphate isomerase; TIM; TPI; Triose-phosphate isomerase; EC 5.3.1.1 from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
P9WG43 triose-phosphate isomerase (EC 5.3.1.1) from Mycobacterium tuberculosis
PFams: TIM
261 amino acids: PaperBLAST, CDD, Compare to cluster

TPIS_PLAFA / Q07412 Triosephosphate isomerase; PfTIM; Triose-phosphate isomerase; EC 5.3.1.1 from Plasmodium falciparum
Q07412 triose-phosphate isomerase (EC 5.3.1.1) from Plasmodium falciparum
PFams: TIM
248 amino acids: PaperBLAST, CDD, Compare to cluster

Q0H294 triose-phosphate isomerase (EC 5.3.1.1) from Pteris vittata
PFams: TIM
253 amino acids: PaperBLAST, CDD, Compare to cluster

Q0ZAG6 triose-phosphate isomerase (EC 5.3.1.1) from Leishmania donovani
PFams: TIM
252 amino acids: PaperBLAST, CDD, Compare to cluster

TPIS_CAEEL / Q10657 Triosephosphate isomerase; TIM; Methylglyoxal synthase; Triose-phosphate isomerase; EC 5.3.1.1; EC 4.2.3.3 from Caenorhabditis elegans
Q10657 triose-phosphate isomerase (EC 5.3.1.1) from Caenorhabditis elegans
PFams: TIM
247 amino acids: PaperBLAST, CDD, Compare to cluster

Q5CSE7 triose-phosphate isomerase (EC 5.3.1.1) from Cryptosporidium parvum
PFams: TIM
250 amino acids: PaperBLAST, CDD, Compare to cluster

Q5S7Y5 triose-phosphate isomerase (EC 5.3.1.1) from Chlamydomonas reinhardtii
PFams: TIM
282 amino acids: PaperBLAST, CDD, Compare to cluster

TPIS_STAAR / Q6GIL6 Triosephosphate isomerase; TIM; TPI; Triose-phosphate isomerase; EC 5.3.1.1 from Staphylococcus aureus (strain MRSA252)
Q6GIL6 triose-phosphate isomerase (EC 5.3.1.1) from Staphylococcus aureus
PFams: TIM
253 amino acids: PaperBLAST, CDD, Compare to cluster

Q7NAQ4 triose-phosphate isomerase (EC 5.3.1.1) from Mycoplasma gallisepticum
PFams: TIM
252 amino acids: PaperBLAST, CDD, Compare to cluster

Q7X216 triose-phosphate isomerase (EC 5.3.1.1) from Klebsiella pneumoniae
PFams: TIM
265 amino acids: PaperBLAST, CDD, Compare to cluster

Q8MPF2 triose-phosphate isomerase (EC 5.3.1.1) from Tenebrio molitor
PFams: TIM
247 amino acids: PaperBLAST, CDD, Compare to cluster

PDB|1M6J_A triosephosphate isomerase; EC 5.3.1.1 from Entamoeba histolytica
PFams: TIM
261 amino acids: PaperBLAST, CDD, Compare to cluster

GI|2143243 triosephosphate isomerase; EC 5.3.1.1 from Entamoeba histolytica
PFams: TIM
261 amino acids: PaperBLAST, CDD, Compare to cluster

TPIS_CANAL / Q9P940 Triosephosphate isomerase; TIM; Triose-phosphate isomerase; EC 5.3.1.1 from Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
CH_123340 triosephosphate isomerase (TIM); EC 5.3.1.1 from Candida albicans
PFams: TIM
248 amino acids: PaperBLAST, CDD, Compare to cluster

CH_125123 triosephosphate isomerase; EC 5.3.1.1 from Schizosaccharomyces pombe
PFams: TIM
249 amino acids: PaperBLAST, CDD, Compare to cluster

TPIS_SCYPA / A0A1L5YRA2 Triosephosphate isomerase; TIM; Allergen Scy p 8; Methylglyoxal synthase; Triose-phosphate isomerase; Allergen Scy p 8.0101; EC 5.3.1.1; EC 4.2.3.3 from Scylla paramamosain (Mud crab)
PFams: TIM
248 amino acids: PaperBLAST, CDD, Compare to cluster

TPIS_PROCL / F5A6E9 Triosephosphate isomerase; TIM; Methylglyoxal synthase; Triose-phosphate isomerase; Allergen Pro c 8.0101; EC 5.3.1.1; EC 4.2.3.3 from Procambarus clarkii (Red swamp crayfish)
PFams: TIM
248 amino acids: PaperBLAST, CDD, Compare to cluster

TPIS_TRYBB / P04789 Triosephosphate isomerase, glycosomal; TIM; Triose-phosphate isomerase; EC 5.3.1.1 from Trypanosoma brucei brucei
P04789 triose-phosphate isomerase (EC 5.3.1.1) from Trypanosoma brucei brucei
PFams: TIM
250 amino acids: PaperBLAST, CDD, Compare to cluster

TPIS_DROME / P29613 Triosephosphate isomerase; TIM; Triose-phosphate isomerase; EC 5.3.1.1 from Drosophila melanogaster (Fruit fly)
PFams: TIM
247 amino acids: PaperBLAST, CDD, Compare to cluster

TPIS_LEIME / P48499 Triosephosphate isomerase; TIM; Triose-phosphate isomerase; EC 5.3.1.1 from Leishmania mexicana
P48499 triose-phosphate isomerase (EC 5.3.1.1) from Leishmania mexicana
PFams: TIM
251 amino acids: PaperBLAST, CDD, Compare to cluster

TPIS_MORMI / P50921 Triosephosphate isomerase; TIM; TPI; Triose-phosphate isomerase; EC 5.3.1.1 from Moritella marina (Vibrio marinus)
P50921 triose-phosphate isomerase (EC 5.3.1.1) from Moritella marina
PDB|1AW1_A triose-phosphate isomerase; EC 5.3.1.1 from Moritella marina
PFams: TIM
256 amino acids: PaperBLAST, CDD, Compare to cluster

TPIS_BACCE / Q4MQ55 Triosephosphate isomerase; TIM; TPI; Triose-phosphate isomerase; EC 5.3.1.1 from Bacillus cereus
PFams: TIM
251 amino acids: PaperBLAST, CDD, Compare to cluster

TPIS_THET8 / Q5SJR1 Triosephosphate isomerase; TIM; TPI; Triose-phosphate isomerase; EC 5.3.1.1 from Thermus thermophilus (strain ATCC 27634 / DSM 579 / HB8)
PFams: TIM
250 amino acids: PaperBLAST, CDD, Compare to cluster

TPIS_BARHE / Q8L1Z5 Triosephosphate isomerase; TIM; TPI; Triose-phosphate isomerase; EC 5.3.1.1 from Bartonella henselae (strain ATCC 49882 / DSM 28221 / CCUG 30454 / Houston 1) (Rochalimaea henselae)
Q8L1Z5 triose-phosphate isomerase (EC 5.3.1.1) from Bartonella henselae
PFams: TIM
254 amino acids: PaperBLAST, CDD, Compare to cluster

TPIS_CLOPE / Q8XKU1 Triosephosphate isomerase; TIM; TPI; Triose-phosphate isomerase; EC 5.3.1.1 from Clostridium perfringens (strain 13 / Type A)
PFams: TIM
248 amino acids: PaperBLAST, CDD, Compare to cluster

TPIS2_LISIN / Q92EU4 Triosephosphate isomerase 2; TIM 2; TPI 2; Triose-phosphate isomerase 2; EC 5.3.1.1 from Listeria innocua serovar 6a (strain ATCC BAA-680 / CLIP 11262)
PFams: TIM
254 amino acids: PaperBLAST, CDD, Compare to cluster

TPIS_PARBA / Q96VN5 Triosephosphate isomerase; TIM; Triose-phosphate isomerase; EC 5.3.1.1 from Paracoccidioides lutzii (strain ATCC MYA-826 / Pb01) (Paracoccidioides brasiliensis)
PFams: TIM
249 amino acids: PaperBLAST, CDD, Compare to cluster

TPIS_DEIRA / Q9RUP5 Triosephosphate isomerase; TIM; TPI; Triose-phosphate isomerase; EC 5.3.1.1 from Deinococcus radiodurans (strain ATCC 13939 / DSM 20539 / JCM 16871 / CCUG 27074 / LMG 4051 / NBRC 15346 / NCIMB 9279 / VKM B-1422 / R1)
PFams: TIM
244 amino acids: PaperBLAST, CDD, Compare to cluster

TPIS_STRCO / Q9Z520 Triosephosphate isomerase; TIM; TPI; Triose-phosphate isomerase; EC 5.3.1.1 from Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)
PFams: TIM
258 amino acids: PaperBLAST, CDD, Compare to cluster

O32757 triosephosphate isomerase subunit (EC 5.3.1.1) from Lactobacillus delbrueckii subsp. bulgaricus
PFams: TIM
252 amino acids: PaperBLAST, CDD, Compare to cluster

P50918 triosephosphate isomerase subunit (EC 5.3.1.1) from Lactococcus lactis subsp. lactis (strain IL1403)
PFams: TIM
252 amino acids: PaperBLAST, CDD, Compare to cluster

G0XRK4 (S)-canadine oxidase (EC 1.3.3.8) from Corydalis saxicola
G0XRK4 tetrahydroberberine oxidase (EC 1.3.3.8) (low-coverage HMM hit) from Corydalis saxicola
PFams: TIM
232 amino acids: PaperBLAST, CDD, Compare to cluster

Cluster 2 216-228 amino acids (not heteromeric)

B6YUE5 triose-phosphate isomerase (EC 5.3.1.1) from Thermococcus onnurineus
PFams: TIM, ThiG
226 amino acids: PaperBLAST, CDD, Compare to cluster

P62003 triose phosphate isomerase subunit (EC 5.3.1.1) from Pyrococcus woesei
TPIS_PYRWO / P62003 Triosephosphate isomerase; TIM; TPI; Triose-phosphate isomerase; EC 5.3.1.1 from Pyrococcus woesei
P62002 triose-phosphate isomerase (EC 5.3.1.1) from Pyrococcus furiosus
P62003 triose-phosphate isomerase (EC 5.3.1.1) from Pyrococcus woesei
PFams: TIM, ThiG
228 amino acids: PaperBLAST, CDD, Compare to cluster

Q12UK2 triose-phosphate isomerase (EC 5.3.1.1) from Methanococcoides burtonii
PFams: TIM
221 amino acids: PaperBLAST, CDD, Compare to cluster

Q58923 triosephosphate isomerase monomer (EC 5.3.1.1) from Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440)
TPIS_METJA / Q58923 Triosephosphate isomerase; TIM; TPI; Triose-phosphate isomerase; EC 5.3.1.1 from Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii)
Q58923 triose-phosphate isomerase (EC 5.3.1.1) from Methanocaldococcus jannaschii
PFams: TIM
219 amino acids: PaperBLAST, CDD, Compare to cluster

Q97VM8 triose-phosphate isomerase (EC 5.3.1.1) from Saccharolobus solfataricus
PFams: TIM
227 amino acids: PaperBLAST, CDD, Compare to cluster

Q9HLB6 triose-phosphate isomerase (EC 5.3.1.1) from Thermoplasma acidophilum
PFams: TIM
216 amino acids: PaperBLAST, CDD, Compare to cluster

TPIS_METBR / O74025 Triosephosphate isomerase; TIM; TPI; Triose-phosphate isomerase; EC 5.3.1.1 from Methanobacterium bryantii
O74025 triose-phosphate isomerase (EC 5.3.1.1) from Methanobacterium bryantii
PFams: TIM
226 amino acids: PaperBLAST, CDD, Compare to cluster

TPIS_THETK / Q8NKN9 Triosephosphate isomerase; TIM; TPI; Triose-phosphate isomerase; EC 5.3.1.1 from Thermoproteus tenax (strain ATCC 35583 / DSM 2078 / JCM 9277 / NBRC 100435 / Kra 1)
Q8NKN9 triose-phosphate isomerase (EC 5.3.1.1) from Thermoproteus tenax
PFams: TIM, ThiG
226 amino acids: PaperBLAST, CDD, Compare to cluster

Singletons (0/2 heteromeric)

P36204 Pgk (EC 2.7.2.3; EC 5.3.1.1) from Thermotoga maritima (strain ATCC 43589 / DSM 3109 / JCM 10099 / NBRC 100826 / MSB8)
PGKT_THEMA / P36204 Bifunctional PGK/TIM; EC 2.7.2.3; EC 5.3.1.1 from Thermotoga maritima (strain ATCC 43589 / DSM 3109 / JCM 10099 / NBRC 100826 / MSB8)
P36204 triose-phosphate isomerase (EC 5.3.1.1) from Thermotoga maritima
PFams: PGK, TIM
654 amino acids: PaperBLAST, CDD

TPIS_PLAOI / P85814 Triosephosphate isomerase; TIM; Triose-phosphate isomerase; Allergen Pla o 4; EC 5.3.1.1 from Platanus orientalis (Oriental plane-tree)
PFams: TIM, TIM
86 amino acids: PaperBLAST, CDD