Clusters of Characterized Proteins
Clustering the characterized proteins for citrullinase (putative citrullinase) in L-citrulline catabolism
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Definition of citrullinase
- Curated proteins or TIGRFams with EC 3.5.1.20
- UniProt sequence Q5NHL7_FRATT: SubName: Full=Carbon-nitrogen hydrolase family protein {ECO:0000313|EMBL:CAG45068.1}; EC=3.5.-.- {ECO:0000313|EMBL:CAG45068.1};
- Curated sequence GFF1616: arginine deiminase (EC 3.5.3.6)
- Curated sequence AO353_25635: arginine deiminase (EC 3.5.3.6)
- Curated sequence GFF3434: arginine deiminase (EC 3.5.3.6)
- Comment: The characterized enzyme hydrolyzes citrulline to ornithine, carbon dioxide, and ammonia (FTT0435 or FTT_0435 or Q5NHL7_FRATT; PMID:19502406). Genetic evidence from diverse bacteria shows that a family of putative hydrolases is involved in ornithine utilization: PGA1_c16380 (GFF1616) from Phaeobacter inhibens; AO353_25635 from Pseudomonas fluorescens FW300-N2E3, and PS417_17580 (GFF3434) from Pseudomonas simiae WCS417. These are distantly related to arginine deiminases and were originally reannotated as such (operating in reverse), but Equilibrator predicts that the reverse reaction is thermodynamically very unfavorable. Also, the guanidino-binding residues are not conserved. They are probably citrullinases.
Fetched 4 sequences
Running BLASTp
Found similarities, at above 30% identity and 75% coverage, for 3 of these sequences
Found 1 clusters of similar sequences. Another 1 sequences are not clustered. Download as table or as draft rules or view by organism
Cluster 1 308-311 amino acids (not heteromeric)
The first sequence in each cluster is the seed.PGA1_c16380 arginine deiminase (EC 3.5.3.6) from Phaeobacter inhibens BS107
PFams: Amidinotransf
309 amino acids: PaperBLAST, CDD, Compare to cluster
PS417_17580 arginine deiminase (EC 3.5.3.6) from Pseudomonas simiae WCS417
PFams: Amidinotransf
308 amino acids: PaperBLAST, CDD, Compare to cluster
AO353_25635 arginine deiminase (EC 3.5.3.6) from Pseudomonas fluorescens FW300-N2E3
PFams: Amidinotransf
311 amino acids: PaperBLAST, CDD, Compare to cluster
Singletons (0/1 heteromeric)
Q5NHL7_FRATT Carbon-nitrogen hydrolase family protein; EC=3.5.-.-
286 amino acids: PaperBLAST, CDD