Clusters of Characterized Proteins

Clustering the characterized proteins for CBS (cystathionine beta-synthase) in L-cysteine biosynthesis

Or see other characterized proteins similar to CBS

Or see all steps for L-cysteine biosynthesis

Or cluster curated proteins matching a keyword

Definition of CBS

• Curated proteins or TIGRFams with EC 4.2.1.22
• Ignore hits to Q3TWN3 when looking for 'other' hits (cystathionine beta-synthase (EC 4.2.1.22). Metal transporter CNNM2; Ancient conserved domain-containing protein 2; mACDP2; Cyclin-M2)
• Ignore hits to Q5SK23 when looking for 'other' hits (cystathionine beta-synthase (EC 4.2.1.22))
• Ignore hits to Q9EYM7 when looking for 'other' hits (cysteine-S-conjugate beta-lyase (EC 4.4.1.13))
• Ignore hits to HS04050-MONOMER when looking for 'other' hits (cystathionine gamma-lyase (EC 4.4.1.1). Cystathionine gamma-lyase; CGL; CSE; Cysteine desulfhydrase; Cysteine-protein sulfhydrase; Gamma-cystathionase; Homocysteine desulfhydrase; EC 4.4.1.1; EC 4.4.1.2. cystathionine γ-lyase monomer (EC 4.4.1.1; EC 4.4.1.2; EC 4.2.1.22))
• Comment: Q3TWN3 and Q5SK23 are misannotated in BRENDA. Q9EYM7 may well have this activity (PMID:12101301). Human CGL is given this EC number as well by metacyc (link), but is not expected to form cystathionine from serine + homocysteine.

Fetched 13 sequences

Running BLASTp

Found similarities, at above 30% identity and 75% coverage, for 12 of these sequences

Found 3 clusters of similar sequences. Another 1 sequences are not clustered. Download as table or as draft rules or view by organism

Cluster 1 464-561 amino acids (not heteromeric)

P32582 Cys4 (EC 4.2.1.22) from Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
CBS_YEAST / P32582 Cystathionine beta-synthase; Beta-thionase; Serine sulfhydrase; Sulfur transfer protein 4; EC 4.2.1.22 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
P32582 cystathionine beta-synthase (EC 4.2.1.22) from Saccharomyces cerevisiae
PFams: PALP, CBS
507 amino acids: PaperBLAST, CDD, Compare to cluster

P35520 cystathionine β-synthase monomer (EC 4.2.1.22) from Homo sapiens
CBS_HUMAN / P35520 Cystathionine beta-synthase; Beta-thionase; Serine sulfhydrase; EC 4.2.1.22 from Homo sapiens (Human)
P35520 cystathionine beta-synthase (EC 4.2.1.22) from Homo sapiens
PFams: PALP, CBS
551 amino acids: PaperBLAST, CDD, Compare to cluster

CBS_APIME / Q2V0C9 Cystathionine beta-synthase; EC 4.2.1.22 from Apis mellifera (Honeybee)
Q2V0C9 cystathionine beta-synthase (EC 4.2.1.22) from Apis mellifera
PFams: PALP
504 amino acids: PaperBLAST, CDD, Compare to cluster

Q9VRD9 cystathionine beta-synthase (EC 4.2.1.22) from Drosophila melanogaster
PFams: PALP, CBS
522 amino acids: PaperBLAST, CDD, Compare to cluster

CH_122414 cystathionine beta-synthase; EC 4.2.1.22 from Emericella nidulans
PFams: PALP, CBS
533 amino acids: PaperBLAST, CDD, Compare to cluster

P32232 cystathionine β-synthase subunit (EC 4.2.1.22) from Rattus norvegicus
CBS_RAT / P32232 Cystathionine beta-synthase; Beta-thionase; Hemoprotein H-450; Serine sulfhydrase; EC 4.2.1.22 from Rattus norvegicus (Rat)
PFams: PALP, CBS
561 amino acids: PaperBLAST, CDD, Compare to cluster

Y1077_MYCTU / P9WP51 Probable cystathionine beta-synthase Rv1077; Beta-thionase; Serine sulfhydrase; EC 4.2.1.22 from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
PFams: PALP, CBS, CBS
464 amino acids: PaperBLAST, CDD, Compare to cluster

A0A563XPB1 cystathionine β-synthase (EC 4.2.1.22) from Gallus gallus
PFams: PALP, CBS
524 amino acids: PaperBLAST, CDD, Compare to cluster

Cluster 2 303-306 amino acids (not heteromeric)

F9UT54 cysteine synthase (EC 2.5.1.47); cystathionine beta-synthase (EC 4.2.1.22) from Lactiplantibacillus plantarum
PFams: PALP
303 amino acids: PaperBLAST, CDD, Compare to cluster

P56067 cystathionine β-synthase (O-acetyl-L-serine) monomer (EC 4.2.1.22; EC 2.5.1.134; EC 2.5.1.47) from Helicobacter pylori (strain ATCC 700392 / 26695)
PFams: PALP
306 amino acids: PaperBLAST, CDD, Compare to cluster

Cluster 3 662-704 amino acids (not heteromeric)

CBS1_CAEEL / G5EFH8 Cystathionine beta-synthase cbs-1; Beta-thionase; Serine sulfhydrase; EC 4.2.1.22 from Caenorhabditis elegans
PFams: PALP, PALP
704 amino acids: PaperBLAST, CDD, Compare to cluster

CBS2_CAEEL / Q9N4K2 Putative cystathionine beta-synthase cbs-2; EC 4.2.1.22 from Caenorhabditis elegans
PFams: PALP, PALP
662 amino acids: PaperBLAST, CDD, Compare to cluster

Singletons (0/1 heteromeric)

Q9YBL2 O-phosphoserine sulfhydrylase monomer (EC 2.5.1.65) from Aeropyrum pernix (strain ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138 / K1)
CYSO_AERPE / Q9YBL2 Protein CysO; Cystathionine beta-synthase; Cysteine synthase; O-acetylserine sulfhydrylase; O-phosphoserine sulfhydrylase; Serine sulfhydrase; EC 4.2.1.22; EC 2.5.1.47; EC 2.5.1.65 from Aeropyrum pernix (strain ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138 / K1)
Q9YBL2 cysteine synthase (EC 2.5.1.47); O-phosphoserine sulfhydrylase (EC 2.5.1.65) from Aeropyrum pernix
PFams: PALP
389 amino acids: PaperBLAST, CDD