Clusters of Characterized Proteins

GapMind for Amino acid biosynthesis

Clusters of Characterized Proteins

Clustering the characterized proteins for CGL (cystathionine gamma-lyase) in L-cysteine biosynthesis

Or see other characterized proteins similar to CGL

Or see all steps for L-cysteine biosynthesis

Or cluster curated proteins matching a keyword

Definition of CGL

Curated proteins matching cystathionine gamma-lyase
Curated proteins matching cystathionine-gamma-lyase
Ignore hits to Q9M1R1 when looking for 'other' hits (cystathionine gamma-lyase (EC 4.4.1.1). L-cysteine desulfhydrase; AtL-CDes1; L-CDes1; AtLCD; EC 4.4.1.28)
Ignore hits to F4K5T2 when looking for 'other' hits (L-cysteine desulfidase (EC 4.4.1.28). Bifunctional cystathionine gamma-lyase/cysteine synthase; Beta-substituted Ala synthase 4;3; ARAth-Bsas4;3; L-cysteine desulfhydrase 1; DES1; O-acetylserine (thiol)-lyase; OASTL; Protein CS-LIKE; EC 2.5.1.47; EC 4.4.1.1)
Ignore hits to Q1M0P5 when looking for 'other' hits (Cystathionine gamma-synthase; CGS; O-succinylhomoserine (thiol)-lyase; EC 2.5.1.48. cystathionine gamma-synthase (EC 2.5.1.48))
Ignore hits to CH_088676 when looking for 'other' hits (cystathionine beta-lyase; EC 4.4.1.8)
Comment: EC 4.4.1.1 includes some other reactions, so it is not used to define CGL. Q9M1R1 is misannotated in BRENDA. SwissProt annotates the cysteine desulfurase DES1 (F4K5T2) with this activity, but we did not find evidence for it, so it is ignored. "MetB" from Helicobacter pylori was originally reported to be a cystathionine gamma-synthase (i.e., Q1M0P5 in BRENDA), but was later identified as a CGL (PMC2820867), so Q1M0P5 is ignored. Similarly, "MetC" from Lactoccus lactis (A2RM21) is reported to be a CGL and a cystathionine beta-lyase (PMID:10620674); another paper proposed that it is a CBL but did not distinguish between the two activities (PMC91783, cited by CharProtDB, which is ignored).

Fetched 17 sequences

Running BLASTp

Found similarities, at above 30% identity and 75% coverage, for 17 of these sequences

Found 1 clusters of similar sequences. Download as table or as draft rules or view by organism

Cluster 1 379-426 amino acids (2/17 heteromeric)

The first sequence in each cluster is the seed.

A2RM21 cystathionine gamma-lyase (EC 4.4.1.1); cysteine-S-conjugate beta-lyase (EC 4.4.1.13) from Lactococcus lactis
RF|YP_001033049.1 cystathionine beta-lyase; EC 4.4.1.8 from Lactococcus lactis subsp. cremoris MG1363
PFams: Cys_Met_Meta_PP, Aminotran_1_2, DegT_DnrJ_EryC1, Aminotran_5
380 amino acids: PaperBLAST, CDD, Compare to cluster

B3TNN8 cystathionine gamma-lyase (subunit 2/2) (EC 4.4.1.1); cysteine-S-conjugate beta-lyase (EC 4.4.1.13) from Lacticaseibacillus casei
PFams: Cys_Met_Meta_PP, Aminotran_1_2, DegT_DnrJ_EryC1, Aminotran_5
Heteromeric, 394 amino acids: PaperBLAST, CDD, Compare to cluster

B3TNN9 cystathionine gamma-lyase (subunit 1/2) (EC 4.4.1.1); cysteine-S-conjugate beta-lyase (EC 4.4.1.13) from Lacticaseibacillus casei
PFams: Cys_Met_Meta_PP, Aminotran_1_2, Aminotran_5
Heteromeric, 394 amino acids: PaperBLAST, CDD, Compare to cluster

B6K8Y1 cystathionine gamma-lyase (EC 4.4.1.1) from Toxoplasma gondii
PFams: Cys_Met_Meta_PP, DegT_DnrJ_EryC1, Aminotran_1_2, Aminotran_5
417 amino acids: PaperBLAST, CDD, Compare to cluster

E9AFE7 cystathionine gamma-lyase (EC 4.4.1.1) from Leishmania major
PFams: Cys_Met_Meta_PP, DegT_DnrJ_EryC1
409 amino acids: PaperBLAST, CDD, Compare to cluster

MCCB_BACSU / O05394 Cystathionine gamma-lyase; Gamma-cystathionase; Homocysteine gamma-lyase; EC 4.4.1.1; EC 4.4.1.2 from Bacillus subtilis (strain 168)
O05394 cystathionine beta-synthase (O-acetyl-L-serine) (EC 2.5.1.134) from Bacillus subtilis
PFams: Cys_Met_Meta_PP, DegT_DnrJ_EryC1, Aminotran_1_2, Aminotran_5
379 amino acids: PaperBLAST, CDD, Compare to cluster

P31373 Cys3 (EC 4.4.1.1) from Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
CYS3_YEAST / P31373 Cystathionine gamma-lyase; gamma-CTLase; Gamma-cystathionase; Sulfur transfer protein 1; EC 4.4.1.1 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
P31373 cystathionine gamma-lyase (EC 4.4.1.1) from Saccharomyces cerevisiae
PFams: Cys_Met_Meta_PP
394 amino acids: PaperBLAST, CDD, Compare to cluster

P32929 cystathionine γ-lyase monomer (EC 4.4.1.1; EC 4.4.1.2; EC 4.2.1.22) from Homo sapiens
CGL_HUMAN / P32929 Cystathionine gamma-lyase; CGL; CSE; Cysteine desulfhydrase; Cysteine-protein sulfhydrase; Gamma-cystathionase; Homocysteine desulfhydrase; EC 4.4.1.1; EC 4.4.1.2 from Homo sapiens (Human)
P32929 cystathionine gamma-lyase (EC 4.4.1.1) from Homo sapiens
PFams: Cys_Met_Meta_PP, Aminotran_1_2, DegT_DnrJ_EryC1, Aminotran_5
405 amino acids: PaperBLAST, CDD, Compare to cluster

Q4WCI1 cystathionine gamma-lyase (EC 4.4.1.1) from Aspergillus fumigatus
PFams: Cys_Met_Meta_PP, DegT_DnrJ_EryC1, Aminotran_1_2
412 amino acids: PaperBLAST, CDD, Compare to cluster

Q5H4T8 cystathionine gamma-lyase (EC 4.4.1.1) from Xanthomonas oryzae pv. oryzae
PFams: Cys_Met_Meta_PP
397 amino acids: PaperBLAST, CDD, Compare to cluster

Q96VU7 cystathionine gamma-lyase (EC 4.4.1.1) from Neurospora crassa
PFams: Cys_Met_Meta_PP, Aminotran_1_2, Aminotran_5
417 amino acids: PaperBLAST, CDD, Compare to cluster

B2LXT6 cystathionine gamma-lyase (EC 4.4.1.1) from Aspergillus nidulans
CH_122519 cystathionine gamma-lyase; EC 4.4.1.1 from Emericella nidulans
PFams: Cys_Met_Meta_PP, DegT_DnrJ_EryC1, Aminotran_1_2
419 amino acids: PaperBLAST, CDD, Compare to cluster

CH_124009 cystathionine-gamma-lyase [Acremonium chrysogenum] from Magnaporthe grisea 70-15
PFams: Cys_Met_Meta_PP, Aminotran_1_2
426 amino acids: PaperBLAST, CDD, Compare to cluster

P18757 cystathionine γ-lyase subunit (EC 4.4.1.1) from Rattus norvegicus
CGL_RAT / P18757 Cystathionine gamma-lyase; CGL; CSE; Cysteine desulfhydrase; Cysteine-protein sulfhydrase; Gamma-cystathionase; Homocysteine desulfhydrase; Probasin-related antigen; PRB-RA; EC 4.4.1.1; EC 4.4.1.2 from Rattus norvegicus (Rat)
PFams: Cys_Met_Meta_PP, DegT_DnrJ_EryC1, Aminotran_1_2, Aminotran_5
398 amino acids: PaperBLAST, CDD, Compare to cluster

CGL_DICDI / Q55DV9 Cystathionine gamma-lyase; CGL; CSE; Cysteine desulfhydrase; Cysteine-protein sulfhydrase; Gamma-cystathionase; Homocysteine desulfhydrase; EC 4.4.1.1; EC 4.4.1.2 from Dictyostelium discoideum (Social amoeba)
PFams: Cys_Met_Meta_PP, Aminotran_1_2
387 amino acids: PaperBLAST, CDD, Compare to cluster

CGL_MOUSE / Q8VCN5 Cystathionine gamma-lyase; CGL; CSE; Cysteine desulfhydrase; Cysteine-protein sulfhydrase; Gamma-cystathionase; Homocysteine desulfhydrase; EC 4.4.1.1; EC 4.4.1.2 from Mus musculus (Mouse)
PFams: Cys_Met_Meta_PP, Aminotran_1_2, DegT_DnrJ_EryC1
398 amino acids: PaperBLAST, CDD, Compare to cluster

P56069 cystathionine gamma-lyase (EC 4.4.1.1) from Helicobacter pylori (strain ATCC 700392 / 26695)
PFams: Cys_Met_Meta_PP, Aminotran_1_2
380 amino acids: PaperBLAST, CDD, Compare to cluster