Clusters of Characterized Proteins

GapMind for Amino acid biosynthesis

Clusters of Characterized Proteins

Clustering the characterized proteins for PSSH (O-phosphoserine sulfhydrylase) in L-cysteine biosynthesis

Or see other characterized proteins similar to PSSH

Or see all steps for L-cysteine biosynthesis

Or cluster curated proteins matching a keyword

Definition of PSSH

Curated proteins or TIGRFams with EC 2.5.1.65
Ignore hits to P9WP53 when looking for 'other' hits ([CysO sulfur-carrier protein]-thiocarboxylate-dependent cysteine synthase (EC 2.5.1.113); O-phosphoserine sulfhydrylase (EC 2.5.1.65). O-phosphoserine sulfhydrylase; OPS sulfhydrylase; CysO-thiocarboxylate-dependent cysteine synthase; Cysteine synthase B; CSase B; O-phosphoserine-specific cysteine synthase; [CysO sulfur-carrier protein]-thiocarboxylate-dependent cysteine synthase; EC 2.5.1.113. CysO-thiocarboxylate-dependent cysteine synthase monomer (EC 2.5.1.113))
Ignore hits to A2GMG5 when looking for 'other' hits (cysteine synthase (EC 2.5.1.47))
Comment: BRENDA misannotates Mt_cysM (P9WP53) as this. Trichomonas cysteine synthase (A2GMG5) probably has this activity as well, so similarity to it is ignored.

Fetched 4 sequences

Running BLASTp

Found similarities, at above 30% identity and 75% coverage, for 3 of these sequences

Found 1 clusters of similar sequences. Another 1 sequences are not clustered. Download as table or as draft rules or view by organism

Cluster 1 273-372 amino acids (not heteromeric)

The first sequence in each cluster is the seed.

A2EI82 O-phosphoserine sulfhydrylase monomer (EC 2.5.1.47; EC 2.5.1.65) from Trichomonas vaginalis (strain ATCC PRA-98 / G3)
PFams: PALP
299 amino acids: PaperBLAST, CDD, Compare to cluster

Q79FV4 3-phospho-L-serine-dependent S-sulfo-L-cysteine synthase (EC 2.8.5.1) from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
CYSK2_MYCTU / Q79FV4 S-sulfocysteine synthase; O-phospho-L-serine-dependent S-sulfocysteine synthase; OPS-dependent S-sulfocysteine synthase; O-phosphoserine sulfhydrylase; EC 2.8.5.1; EC 2.5.1.65 from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Q79FV4 cysteine synthase (EC 2.5.1.47); O-phosphoserine sulfhydrylase (EC 2.5.1.65) from Mycobacterium tuberculosis
PFams: PALP
372 amino acids: PaperBLAST, CDD, Compare to cluster

Q5JIZ7 O-phosphoserine sulfhydrylase monomer (EC 2.5.1.65) from Thermococcus kodakarensis (strain ATCC BAA-918 / JCM 12380 / KOD1)
PFams: PALP
273 amino acids: PaperBLAST, CDD, Compare to cluster

Singletons (0/1 heteromeric)

Q9YBL2 O-phosphoserine sulfhydrylase monomer (EC 2.5.1.65) from Aeropyrum pernix (strain ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138 / K1)
CYSO_AERPE / Q9YBL2 Protein CysO; Cystathionine beta-synthase; Cysteine synthase; O-acetylserine sulfhydrylase; O-phosphoserine sulfhydrylase; Serine sulfhydrase; EC 4.2.1.22; EC 2.5.1.47; EC 2.5.1.65 from Aeropyrum pernix (strain ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138 / K1)
Q9YBL2 cysteine synthase (EC 2.5.1.47); O-phosphoserine sulfhydrylase (EC 2.5.1.65) from Aeropyrum pernix
PFams: PALP
389 amino acids: PaperBLAST, CDD