Clusters of Characterized Proteins

GapMind for Amino acid biosynthesis

Clusters of Characterized Proteins

Clustering the characterized proteins for serA (3-phosphoglycerate dehydrogenase) in L-cysteine biosynthesis

Or see other characterized proteins similar to serA

Or see all steps for L-cysteine biosynthesis

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Definition of serA

Curated proteins or TIGRFams with EC 1.1.1.95
UniProt sequence A0A1X9ZCD3: SubName: Full=3-phosphoglycerate dehydrogenase {ECO:0000313|EMBL:ARS42937.1};
UniProt sequence Q6LWW6: RecName: Full=D-3-phosphoglycerate dehydrogenase {ECO:0000256|RuleBase:RU363003}; EC=1.1.1.95 {ECO:0000256|RuleBase:RU363003};
Ignore hits to Q4JDI4 when looking for 'other' hits (phosphoglycerate kinase (EC 2.7.2.3))
Ignore hits to HP_RS05420-MONOMER when looking for 'other' hits (cinnamyl-alcohol dehydrogenase (EC 1.1.1.2; EC 1.1.1.95; EC 1.1.1.195))
Ignore hits to SGL_RS08600-MONOMER when looking for 'other' hits (glycerate dehydrogenase (EC 1.1.1.29))
Predicted: UniProt sequence A0A374I5P9: RecName: Full=D-3-phosphoglycerate dehydrogenase {ECO:0000256|ARBA:ARBA00021582}; EC=1.1.1.399 {ECO:0000256|ARBA:ARBA00013001}; EC=1.1.1.95 {ECO:0000256|ARBA:ARBA00013143}; AltName: Full=2-oxoglutarate reductase {ECO:0000256|ARBA:ARBA00030455};
UniProt sequence Q5JGC4: SubName: Full=D-3-phosphoglycerate dehydrogenase {ECO:0000313|EMBL:BAD86155.1};
Comment: BRENDA::Q4JDI4 is misannotated as 3-phosphoglycerate dehydrogenase instead of 3-phosphoglycerate kinase. (The curators were notified and report that they have corrected this.) CA265_RS09010 (A0A1X9ZCD3) from Pedobacter sp. GW460-11-11-14-LB5 is annotated as 3-phosphoglycerate dehydrogenase and has auxotrophic phenotypes. In particular, mutants are partially rescued by glycine or serine. Also it is adjacent to the putative serC. MMP1588 (Q6LWW6) was identified as the serA of Methanococcus (PMC1797378). Ignore link_RS05420-MONOMER which has this EC but has a different function. Ignore similarity to sll1908 (link_RS08600-MONOMER) which seems likely to be serA but was proposed (without experimental evidence) to be hydroxpyruvate reductase. In Roseburia faecis, the putative serA (A0A374I5P9) is diverged but is similar to the serA part of Echvi_2777 and is conserved next to serC and DUF1015 (putative serB). In Thermococcus kodakarensis, TK1966 (Q5JGC4) is the 3-phosphoglycerate dehydrogenase (PMC5120207).

Fetched 31 sequences

Running BLASTp

Found similarities, at above 30% identity and 75% coverage, for 29 of these sequences

Found 4 clusters of similar sequences. Another 2 sequences are not clustered. Download as table or as draft rules or view by organism

Cluster 1 523-630 amino acids (not heteromeric)

P9WNX3 phosphoglycerate dehydrogenase (EC 1.1.1.95) from Mycobacterium tuberculosis
PFams: 2-Hacid_dh, 2-Hacid_dh_C, NAD_binding_2, PGDH_inter, ACT
528 amino acids: PaperBLAST, CDD, Compare to cluster

A0A1Z4EAX3 phosphoglycerate dehydrogenase (EC 1.1.1.95) from Beta vulgaris
PFams: 2-Hacid_dh, 2-Hacid_dh_C, IlvN, PGDH_inter, ACT
622 amino acids: PaperBLAST, CDD, Compare to cluster

A0A1Z4EAX4 phosphoglycerate dehydrogenase (EC 1.1.1.95) from Beta vulgaris
PFams: 2-Hacid_dh, 2-Hacid_dh_C, IlvN, PGDH_inter, ACT
622 amino acids: PaperBLAST, CDD, Compare to cluster

A0A2R6X868 phosphoglycerate dehydrogenase (EC 1.1.1.95) from Marchantia polymorpha
PFams: 2-Hacid_dh, 2-Hacid_dh_C, IlvN, PGDH_inter, ACT
630 amino acids: PaperBLAST, CDD, Compare to cluster

SERA2_ARATH / O04130 D-3-phosphoglycerate dehydrogenase 2, chloroplastic; PGDH; EC 1.1.1.95 from Arabidopsis thaliana (Mouse-ear cress)
O04130 phosphoglycerate dehydrogenase (EC 1.1.1.95) from Arabidopsis thaliana
PFams: 2-Hacid_dh, 2-Hacid_dh_C, IlvN, PGDH_inter, ACT
624 amino acids: PaperBLAST, CDD, Compare to cluster

O08651 3-phosphoglycerate dehydrogenase subunit (EC 1.1.1.95) from Rattus norvegicus
SERA_RAT / O08651 D-3-phosphoglycerate dehydrogenase; 3-PGDH; EC 1.1.1.95 from Rattus norvegicus (Rat)
O08651 phosphoglycerate dehydrogenase (EC 1.1.1.95) from Rattus norvegicus
PFams: 2-Hacid_dh, 2-Hacid_dh_C, PGDH_inter
533 amino acids: PaperBLAST, CDD, Compare to cluster

O43175 D-3-phosphoglycerate dehydrogenase (EC 1.1.1.95) from Homo sapiens
SERA_HUMAN / O43175 D-3-phosphoglycerate dehydrogenase; 3-PGDH; 2-oxoglutarate reductase; Malate dehydrogenase; EC 1.1.1.95; EC 1.1.1.399; EC 1.1.1.37 from Homo sapiens (Human)
O43175 phosphoglycerate dehydrogenase (EC 1.1.1.95) from Homo sapiens
PFams: 2-Hacid_dh, 2-Hacid_dh_C, PGDH_inter
533 amino acids: PaperBLAST, CDD, Compare to cluster

SERA1_ARATH / O49485 D-3-phosphoglycerate dehydrogenase 1, chloroplastic; Protein EMBRYO SAC DEVELOPMENT ARREST 9; EC 1.1.1.95 from Arabidopsis thaliana (Mouse-ear cress)
O49485 phosphoglycerate dehydrogenase (EC 1.1.1.95) from Arabidopsis thaliana
PFams: 2-Hacid_dh, 2-Hacid_dh_C, IlvN, PGDH_inter, ACT
603 amino acids: PaperBLAST, CDD, Compare to cluster

SERA_MOUSE / Q61753 D-3-phosphoglycerate dehydrogenase; 3-PGDH; A10; EC 1.1.1.95 from Mus musculus (Mouse)
Q61753 phosphoglycerate dehydrogenase (EC 1.1.1.95) from Mus musculus
PFams: 2-Hacid_dh, 2-Hacid_dh_C, PGDH_inter
533 amino acids: PaperBLAST, CDD, Compare to cluster

SERA3_ARATH / Q9LT69 D-3-phosphoglycerate dehydrogenase 3, chloroplastic; EC 1.1.1.95 from Arabidopsis thaliana (Mouse-ear cress)
Q9LT69 phosphoglycerate dehydrogenase (EC 1.1.1.95) from Arabidopsis thaliana
PFams: 2-Hacid_dh, 2-Hacid_dh_C, IlvN, PGDH_inter, ACT
588 amino acids: PaperBLAST, CDD, Compare to cluster

Q9Z564 phosphoglycerate dehydrogenase (EC 1.1.1.95) from Streptomyces coelicolor
PFams: 2-Hacid_dh, 2-Hacid_dh_C, PGDH_inter, ACT
529 amino acids: PaperBLAST, CDD, Compare to cluster

GB|AAC83943.1 phosphoglycerate dehydrogenase; EC 1.1.1.95 from Bacillus subtilis
PFams: 2-Hacid_dh, 2-Hacid_dh_C, NAD_binding_2, PGDH_inter, ACT
525 amino acids: PaperBLAST, CDD, Compare to cluster

Q6LWW6 D-3-phosphoglycerate dehydrogenase {ECO:0000256|RuleBase:RU363003}; EC=1.1.1.95 {ECO:0000256|RuleBase:RU363003}
523 amino acids: PaperBLAST, CDD, Compare to cluster

Cluster 2 299-410 amino acids (not heteromeric)

Q5JGC4 D-3-phosphoglycerate dehydrogenase
304 amino acids: PaperBLAST, CDD, Compare to cluster

b2913 phosphoglycerate dehydrogenase (EC 1.1.1.95; EC 1.1.1.399) from Escherichia coli K-12 substr. MG1655
P0A9T0 phosphoglycerate dehydrogenase (EC 1.1.1.95; EC 1.1.1.399) from Escherichia coli (strain K12)
SERA_ECOLI / P0A9T0 D-3-phosphoglycerate dehydrogenase; PGDH; 2-oxoglutarate reductase; EC 1.1.1.95; EC 1.1.1.399 from Escherichia coli (strain K12)
C3SVM7 phosphoglycerate dehydrogenase (EC 1.1.1.95) from Escherichia coli
P0A9T0 phosphoglycerate dehydrogenase (EC 1.1.1.95) from Escherichia coli
RF|NP_417388 D-3-phosphoglycerate dehydrogenase; EC 1.1.1.95 from Escherichia coli K12
PFams: 2-Hacid_dh, 2-Hacid_dh_C, ACT
410 amino acids: PaperBLAST, CDD, Compare to cluster

O58256 phosphoglycerate dehydrogenase (EC 1.1.1.95) from Pyrococcus horikoshii
PFams: 2-Hacid_dh, 2-Hacid_dh_C, IlvN, F420_oxidored, NAD_binding_2
333 amino acids: PaperBLAST, CDD, Compare to cluster

Q76KF5 phosphoglycerate dehydrogenase (EC 1.1.1.95) from Entamoeba histolytica
CH_000791 D-phosphoglycerate dehydrogenase; EC 1.1.1.95 from Entamoeba histolytica HM-1:IMSS
PFams: 2-Hacid_dh, 2-Hacid_dh_C
299 amino acids: PaperBLAST, CDD, Compare to cluster

Q972A9 phosphoglycerate dehydrogenase (EC 1.1.1.95) from Sulfurisphaera tokodaii
PFams: 2-Hacid_dh, 2-Hacid_dh_C
313 amino acids: PaperBLAST, CDD, Compare to cluster

Q9I6H5 phosphoglycerate dehydrogenase (EC 1.1.1.95) from Pseudomonas aeruginosa
PFams: 2-Hacid_dh, 2-Hacid_dh_C
409 amino acids: PaperBLAST, CDD, Compare to cluster

A0A1X9ZCD3 3-phosphoglycerate dehydrogenase
315 amino acids: PaperBLAST, CDD, Compare to cluster

A0A374I5P9 D-3-phosphoglycerate dehydrogenase; EC=1.1.1.399; EC=1.1.1.95; 2-oxoglutarate reductase
387 amino acids: PaperBLAST, CDD, Compare to cluster

A2DLU8 phosphoglycerate dehydrogenase (EC 1.1.1.95) from Trichomonas vaginalis (strain ATCC PRA-98 / G3)
PFams: 2-Hacid_dh, 2-Hacid_dh_C, NAD_binding_2
394 amino acids: PaperBLAST, CDD, Compare to cluster

Sama_3039 Phosphoglycerate dehydrogenase (EC 1.1.1.95) from Shewanella amazonensis SB2B
PFams: 2-Hacid_dh_C, NAD_binding_2
308 amino acids: PaperBLAST, CDD, Compare to cluster

Cluster 3 442-469 amino acids (not heteromeric)

A4VGK3 phosphoglycerate dehydrogenase (EC 1.1.1.95) from Pseudomonas stutzeri
PFams: 2-Hacid_dh, 2-Hacid_dh_C
468 amino acids: PaperBLAST, CDD, Compare to cluster

U3RH61 phosphoglycerate dehydrogenase (EC 1.1.1.95) from Acanthamoeba castellanii
PFams: 2-Hacid_dh, 2-Hacid_dh_C
442 amino acids: PaperBLAST, CDD, Compare to cluster

SERA_YEAST / P40054 D-3-phosphoglycerate dehydrogenase 1; 3-PGDH 1; 2-oxoglutarate reductase; EC 1.1.1.95; EC 1.1.1.399 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
PFams: 2-Hacid_dh, 2-Hacid_dh_C, NAD_binding_2
469 amino acids: PaperBLAST, CDD, Compare to cluster

SER33_YEAST / P40510 D-3-phosphoglycerate dehydrogenase 2; 3-PGDH 2; 2-oxoglutarate reductase; EC 1.1.1.95; EC 1.1.1.399 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
PFams: 2-Hacid_dh, 2-Hacid_dh_C, NAD_binding_2
469 amino acids: PaperBLAST, CDD, Compare to cluster

Cluster 4 1333-1364 amino acids (not heteromeric)

BPHYT_RS03150 Phosphoglycerate dehydrogenase (EC:1.1.1.95) from Burkholderia phytofirmans PsJN
PFams: DUF3683, FAD_binding_4, FAD-oxidase_C, FAD-oxidase_C, Fer4_8, CCG, CCG, DUF3400
1364 amino acids: PaperBLAST, CDD, Compare to cluster

HSERO_RS19500 Putative phosphoglycerate dehydrogenase (EC:1.1.1.95) from Herbaspirillum seropedicae SmR1
PFams: DUF3683, FAD_binding_4, FAD-oxidase_C, FAD-oxidase_C, Fer4_8, CCG, CCG, DUF3400
1333 amino acids: PaperBLAST, CDD, Compare to cluster

Singletons (0/2 heteromeric)

H9JRZ9 phosphoglycerate dehydrogenase (EC 1.1.1.95) from Bombyx mori
PFams: 2-Hacid_dh, 2-Hacid_dh_C
432 amino acids: PaperBLAST, CDD

Echvi_2777 fused D-3-phosphoglycerate dehydrogenase / phosphoserine phosphatase (EC 1.1.1.95; EC 3.1.3.3) from Echinicola vietnamensis KMM 6221, DSM 17526
PFams: HAD, 2-Hacid_dh, 2-Hacid_dh_C, NAD_binding_2
630 amino acids: PaperBLAST, CDD