Clusters of Characterized Proteins

GapMind for Amino acid biosynthesis

Clusters of Characterized Proteins

Clustering the characterized proteins for serC (3-phosphoserine aminotransferase) in L-cysteine biosynthesis

Or see other characterized proteins similar to serC

Or see all steps for L-cysteine biosynthesis

Or cluster curated proteins matching a keyword

Definition of serC

Curated proteins or TIGRFams with EC 2.6.1.52
UniProt sequence Y959_METJA: RecName: Full=Uncharacterized aminotransferase MJ0959; EC=2.6.1.-;
UniProt sequence Q2FXK2: RecName: Full=Aminotransferase class V domain-containing protein {ECO:0000259|Pfam:PF00266};
Predicted: UniProt sequence A5I0W7: SubName: Full=Serine--glyoxylate aminotransferase {ECO:0000313|EMBL:CAL82678.1}; EC=2.6.1.45 {ECO:0000313|EMBL:CAL82678.1};
Predicted: UniProt sequence A0A843E9R6: SubName: Full=Alanine--glyoxylate aminotransferase family protein {ECO:0000313|EMBL:MBO5653953.1};
Predicted: UniProt sequence A0A1T4W7T3: SubName: Full=Aspartate aminotransferase {ECO:0000313|EMBL:SKA73374.1};
Predicted: UniProt sequence A0A097AUI2: SubName: Full=Serine-pyruvate aminotransferase {ECO:0000313|EMBL:AIS53461.1}; EC=2.6.1.51 {ECO:0000313|EMBL:AIS53461.1};
Comment: MJ0959 (Y959_METJA) is phosphoserine transaminase (PMID:17071763). A mutant in the putative aminotransferase SAUSA300_1669 = Q2FXK2 is a serine auxotroph (PMC5912478), and this gene is conserved near other serine synthesis genes (SerC2 in PMC9026213). A5I0W7 is a putative aminotransferase and is conserved near serine synthesis genes (SerC3 in PMC9026213; also see CDIF630erm_01130 in PMC6110889). Some moderately diverged SerC3 homologs are also conserved near serine synthesis genes (A3204_00420, similar to A0A843E9R6; G452_RS0102660, similar to A0A1T4W7T3). In Thermoanaerobacter kivui LKT-1, a putative transaminase (TKV_RS11400, A0A097AUI2) is encoded next to serA; by homology, it might be a serine:pyruvate aminotransferase or a phosphoserine transaminase; given the conserved proximity to serA, we predicted that it is serC.

Fetched 24 sequences

Running BLASTp

Found similarities, at above 30% identity and 75% coverage, for 23 of these sequences

Found 3 clusters of similar sequences. Another 1 sequences are not clustered. Download as table or as draft rules or view by organism

Cluster 1 361-430 amino acids (not heteromeric)

b0907 phosphoserine/phosphohydroxythreonine aminotransferase (EC 2.6.1.52; EC 2.6.1.17) from Escherichia coli K-12 substr. MG1655
P23721 phosphoserine/phosphohydroxythreonine aminotransferase (EC 2.6.1.52; EC 2.6.1.17) from Escherichia coli (strain K12)
SERC_ECOLI / P23721 Phosphoserine aminotransferase; Phosphohydroxythreonine aminotransferase; PSAT; EC 2.6.1.52 from Escherichia coli (strain K12)
P23721 phosphoserine transaminase (EC 2.6.1.52) from Escherichia coli
CH_002572 phosphoserine aminotransferase; EC 2.6.1.52 from Escherichia coli K12
PFams: Aminotran_5
362 amino acids: PaperBLAST, CDD, Compare to cluster

Q2F5M8 phosphoserine transaminase (EC 2.6.1.52) from Bombyx mori
PFams: Aminotran_5
364 amino acids: PaperBLAST, CDD, Compare to cluster

Q96255 phosphoserine aminotransferase (EC 2.6.1.52) from Arabidopsis thaliana
SERB1_ARATH / Q96255 Phosphoserine aminotransferase 1, chloroplastic; AtPSAT1; Phosphohydroxythreonine aminotransferase; EC 2.6.1.52 from Arabidopsis thaliana (Mouse-ear cress)
Q96255 phosphoserine transaminase (EC 2.6.1.52) from Arabidopsis thaliana
PFams: Aminotran_5
430 amino acids: PaperBLAST, CDD, Compare to cluster

SERB2_ARATH / Q9SHP0 Phosphoserine aminotransferase 2, chloroplastic; AtPSAT2; EC 2.6.1.52 from Arabidopsis thaliana (Mouse-ear cress)
Q9SHP0 phosphoserine transaminase (EC 2.6.1.52) from Arabidopsis thaliana
PFams: Aminotran_5
422 amino acids: PaperBLAST, CDD, Compare to cluster

Q9Y617 Phosphoserine aminotransferase (EC 2.6.1.52) from Homo sapiens
SERC_HUMAN / Q9Y617 Phosphoserine aminotransferase; Phosphohydroxythreonine aminotransferase; PSAT; EC 2.6.1.52 from Homo sapiens (Human)
Q9Y617 glycine transaminase (EC 2.6.1.4); phosphoserine transaminase (EC 2.6.1.52) from Homo sapiens
PFams: Aminotran_5
370 amino acids: PaperBLAST, CDD, Compare to cluster

V9NC98 phosphoserine transaminase (EC 2.6.1.52) from Acanthamoeba castellanii
PFams: Aminotran_5
394 amino acids: PaperBLAST, CDD, Compare to cluster

SERC_RABIT / P10658 Phosphoserine aminotransferase; PSAT; Endometrial progesterone-induced protein; EPIP; Phosphohydroxythreonine aminotransferase; EC 2.6.1.52 from Oryctolagus cuniculus (Rabbit)
PFams: Aminotran_5
370 amino acids: PaperBLAST, CDD, Compare to cluster

SERC_YEAST / P33330 Phosphoserine aminotransferase; PSAT; Phosphohydroxythreonine aminotransferase; Serine requiring protein 1; EC 2.6.1.52 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
PFams: Aminotran_5
395 amino acids: PaperBLAST, CDD, Compare to cluster

SERC_SPIOL / P52877 Phosphoserine aminotransferase, chloroplastic; PSAT; Phosphohydroxythreonine aminotransferase; EC 2.6.1.52 from Spinacia oleracea (Spinach)
PFams: Aminotran_5
430 amino acids: PaperBLAST, CDD, Compare to cluster

SERC_NIACI / Q59196 Phosphoserine aminotransferase; Phosphohydroxythreonine aminotransferase; PSAT; EC 2.6.1.52 from Niallia circulans (Bacillus circulans)
Q59196 phosphoserine transaminase (EC 2.6.1.52) from Niallia circulans
PFams: Aminotran_5
362 amino acids: PaperBLAST, CDD, Compare to cluster

SERC_ALKAL / Q9RME2 Phosphoserine aminotransferase; Phosphohydroxythreonine aminotransferase; PSAT; EC 2.6.1.52 from Alkalihalobacillus alcalophilus (Bacillus alcalophilus)
Q9RME2 phosphoserine transaminase (EC 2.6.1.52) from Alkalihalobacillus alcalophilus
PFams: Aminotran_5
361 amino acids: PaperBLAST, CDD, Compare to cluster

SERC_DROME / Q9VAN0 Probable phosphoserine aminotransferase; PSAT; Phosphohydroxythreonine aminotransferase; EC 2.6.1.52 from Drosophila melanogaster (Fruit fly)
PFams: Aminotran_5
364 amino acids: PaperBLAST, CDD, Compare to cluster

A2FXW5 phosphoserine transaminase (EC 2.6.1.52) from Trichomonas vaginalis (strain ATCC PRA-98 / G3)
PFams: Aminotran_5
371 amino acids: PaperBLAST, CDD, Compare to cluster

Cluster 2 356-386 amino acids (not heteromeric)

Y959_METJA Uncharacterized aminotransferase MJ0959; EC=2.6.1.-
385 amino acids: PaperBLAST, CDD, Compare to cluster

P74281 serine—glyoxylate transaminase (EC 2.6.1.52) from Synechocystis sp. (strain PCC 6803 / Kazusa)
P74281 phosphoserine transaminase (EC 2.6.1.52) from Synechocystis sp.
PFams: Aminotran_5
384 amino acids: PaperBLAST, CDD, Compare to cluster

A0A097AUI2 Serine-pyruvate aminotransferase; EC=2.6.1.51
360 amino acids: PaperBLAST, CDD, Compare to cluster

A0A1T4W7T3 Aspartate aminotransferase
378 amino acids: PaperBLAST, CDD, Compare to cluster

A0A843E9R6 Alanine--glyoxylate aminotransferase family protein
356 amino acids: PaperBLAST, CDD, Compare to cluster

A5I0W7 Serine--glyoxylate aminotransferase; EC=2.6.1.45
357 amino acids: PaperBLAST, CDD, Compare to cluster

Q2FXK2 Aminotransferase class V domain-containing protein {ECO:0000259|Pfam:PF00266}
386 amino acids: PaperBLAST, CDD, Compare to cluster

Q58369 phosphoserine aminotransferase monomer (EC 2.6.1.1; EC 2.6.1.52) from Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440)
PFams: Aminotran_5
385 amino acids: PaperBLAST, CDD, Compare to cluster

Cluster 3 370-370 amino acids (not heteromeric)

SERC_METBF / P52878 Phosphoserine aminotransferase; Phosphohydroxythreonine aminotransferase; PSAT; EC 2.6.1.52 from Methanosarcina barkeri (strain Fusaro / DSM 804)
P52878 phosphoserine transaminase (EC 2.6.1.52) from Methanosarcina barkeri
370 amino acids: PaperBLAST, CDD, Compare to cluster

Q8TNI1 phosphoserine aminotransferase monomer (EC 2.6.1.52; EC 2.6.1.1) from Methanosarcina acetivorans (strain ATCC 35395 / DSM 2834 / JCM 12185 / C2A)
370 amino acids: PaperBLAST, CDD, Compare to cluster

Singletons (0/1 heteromeric)

SERC_MYCTU / P9WQ73 Phosphoserine aminotransferase; Phosphohydroxythreonine aminotransferase; PSAT; EC 2.6.1.52 from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
P9WQ73 phosphoserine transaminase (EC 2.6.1.52) from Mycobacterium tuberculosis
PFams: Aminotran_5
376 amino acids: PaperBLAST, CDD