Clusters of Characterized Proteins

Clustering the characterized proteins for nupA (deoxyinosine ABC transporter, ATPase component) in 2'-deoxyinosine catabolism

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Definition of nupA

• Curated sequence A2RKA7: Purine/cytidine ABC transporter ATP-binding protein, component of General nucleoside uptake porter, NupABC/BmpA (transports all common nucleosides as well as 5-fluorocytidine, inosine, deoxyuridine and xanthosine) (Martinussen et al., 2010) (Most similar to 3.A.1.2.12). NupA is 506aas with two ABC (C) domains. NupB has 8 predicted TMSs, NupC has 9 or 10 predicted TMSs in a 4 + 1 (or 2) + 4 arrangement
• Curated sequence Q8DU37: RnsB, component of The (deoxy)ribonucleoside permease; probably takes up all deoxy- and ribonucleosides (cytidine, uridine, adenosine and toxic analogues, fluorocytidine and fluorouridine tested), but not ribose or nucleobases
• Comment: In Lactococcus lactis, a 4-component ABC transporter is active on deoxyinosine A related system, RnsBCDA from Streptococcus mutans, also probably transports deoxyinosine

Fetched 2 sequences

Running BLASTp

Found similarities, at above 30% identity and 75% coverage, for 2 of these sequences

Found 1 clusters of similar sequences. Download as table or as draft rules or view by organism

Cluster 1 506-510 amino acids (heteromeric)

TC 3.A.1.2.17 / A2RKA7 Purine/cytidine ABC transporter ATP-binding protein, component of General nucleoside uptake porter, NupABC/BmpA (transports all common nucleosides as well as 5-fluorocytidine, inosine, deoxyuridine and xanthosine) (Martinussen et al., 2010) (Most similar to 3.A.1.2.12). NupA is 506aas with two ABC (C) domains. NupB has 8 predicted TMSs, NupC has 9 or 10 predicted TMSs in a 4 + 1 (or 2) + 4 arrangement from Lactococcus lactis subsp. cremoris (strain MG1363)
PFams: ABC_tran, ABC_tran
Heteromeric, 506 amino acids: PaperBLAST, CDD, Compare to cluster

TC 3.A.1.2.12 / Q8DU37 RnsB, component of The (deoxy)ribonucleoside permease; probably takes up all deoxy- and ribonucleosides (cytidine, uridine, adenosine and toxic analogues, fluorocytidine and fluorouridine tested), but not ribose or nucleobases from Streptococcus mutans
PFams: ABC_tran, ABC_tran
Heteromeric, 510 amino acids: PaperBLAST, CDD, Compare to cluster