Clusters of Characterized Proteins

Clustering the characterized proteins for nupC (deoxyinosine:H+ symporter NupC) in 2'-deoxyinosine catabolism

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Definition of nupC

• Curated sequence O25792: Nucleoside permease NupC
• Curated sequence P0AFF2: Nucleoside permease NupC; Nucleoside-transport system protein NupC. Pyrimidine nucleoside:H+ symporter, NupC (Craig et al. 1994; Patching et al. 2005). Wild-type NupC had an apparent affinity for uridine of 22.2 +/- 3.7 muM and an apparent binding affinity of 1.8-2.6 mM, and various mutants with alterred properties were isolated and characterized (Sun et al. 2017). ADP-glucose is also a substrate of this system. nucleoside:H⁺ symporter NupC. nucleoside:H⁺ symporter NupC
• Curated sequence P42312: Purine nucleoside transport protein NupG. The purine nucleoside uptake transporter NupG (YxjA)
• Curated sequence Q9KPL5: Concentrative nucleoside transporter, CNT, of 418 aas and 12 TMSs. A repeat-swapped model of VcCNT predicts that nucleoside transport occurs via a mechanism involving an elevator-like substrate binding domain movement across the membrane
• Ignore hits to P33021 when looking for 'other' hits (Putative nucleoside permease NupX. Nucleoside permease NupX. putative nucleoside transporter)
• Comment: These proteins are reported to transport inosine, and likely transport deoxyinosine as well. The specificity of E. coli nupX (P33021, also known as yeiJ) seems to be unknown.

Fetched 4 sequences

Running BLASTp

Found similarities, at above 30% identity and 75% coverage, for 4 of these sequences

Found 2 clusters of similar sequences. Download as table or as draft rules or view by organism

Cluster 1 397-400 amino acids (not heteromeric)

b2393 nucleoside:H⁺ symporter NupC from Escherichia coli K-12 substr. MG1655
P0AFF2 nucleoside:H⁺ symporter NupC from Escherichia coli (strain K12)
NUPC_ECOLI / P0AFF2 Nucleoside permease NupC; Nucleoside-transport system protein NupC from Escherichia coli (strain K12)
TC 2.A.41.1.1 / P0AFF2 Pyrimidine nucleoside:H+ symporter, NupC (Craig et al. 1994; Patching et al. 2005). Wild-type NupC had an apparent affinity for uridine of 22.2 +/- 3.7 muM and an apparent binding affinity of 1.8-2.6 mM, and various mutants with alterred properties were isolated and characterized (Sun et al. 2017). ADP-glucose is also a substrate of this system from Escherichia coli
PFams: Nucleos_tra2_N, Gate, Nucleos_tra2_C
400 amino acids: PaperBLAST, CDD, Compare to cluster

NUPG_BACSU / P42312 Purine nucleoside transport protein NupG from Bacillus subtilis (strain 168)
TC 2.A.41.1.3 / P42312 The purine nucleoside uptake transporter NupG (YxjA) from Bacillus subtilis
PFams: Nucleos_tra2_N, Nucleos_tra2_C
397 amino acids: PaperBLAST, CDD, Compare to cluster

Cluster 2 418-418 amino acids (not heteromeric)

NUPC_HELPY / O25792 Nucleoside permease NupC from Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
PFams: Nucleos_tra2_N, Nucleos_tra2_C
418 amino acids: PaperBLAST, CDD, Compare to cluster

TC 2.A.41.2.11 / Q9KPL5 Concentrative nucleoside transporter, CNT, of 418 aas and 12 TMSs. A repeat-swapped model of VcCNT predicts that nucleoside transport occurs via a mechanism involving an elevator-like substrate binding domain movement across the membrane from Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961)
PFams: Nucleos_tra2_N, Gate, Nucleos_tra2_C
418 amino acids: PaperBLAST, CDD, Compare to cluster