Clusters of Characterized Proteins

Clustering the characterized proteins for dctA (fumarate:H+ symporter DctA) in fumarate catabolism

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Definition of dctA

• Curated sequence CH_014038: aerobic C4-dicarboxylate transport protein. Aerobic C4-dicarboxylate transport protein. Aerobic dicarboxylate transporter, DctA. Interacts with the DcuS sensor kinase. C4 dicarboxylate/orotate:H⁺ symporter. C4 dicarboxylate/orotate:H⁺ symporter
• Curated sequence P96603: The dicarboxylate (succinate, fumarate, malate and oxaloacetate):H+ symporter, DctA (probably 3H+ are transported per succinate taken up
• Curated sequence Q01857: C4-dicarboxylate transporter (substrates: fumarate, D- and L-malate, succinate, succinamide, orotate, iticonate, mesaconate)
• Curated sequence Q1J1H5: Fumarate:H+ symporter of 442 aas and 14 established TMSs, DctA. Responsible for the transport of dicarboxylates such as succinate, fumarate, and malate
• Curated sequence Q848I3: Organic acid uptake porter, DctA of 444 aas and 8 - 10 putative TMSs
• Curated sequence AO356_18980: sodium:C4-dicarboxylate symporter (dctA)
• Curated sequence Q9I4F5: C4-dicarboxylate transport protein 2

Fetched 7 sequences

Running BLASTp

Found similarities, at above 30% identity and 75% coverage, for 7 of these sequences

Found 1 clusters of similar sequences. Download as table or as draft rules or view by organism

Cluster 1 421-450 amino acids (not heteromeric)

b3528 C4 dicarboxylate/orotate:H⁺ symporter from Escherichia coli K-12 substr. MG1655
P0A830 C4 dicarboxylate/orotate:H⁺ symporter from Escherichia coli (strain K12)
DCTA_ECOLI / P0A830 Aerobic C4-dicarboxylate transport protein from Escherichia coli (strain K12)
TC 2.A.23.1.7 / P0A830 Aerobic dicarboxylate transporter, DctA. Interacts with the DcuS sensor kinase from Escherichia coli (strain K12)
GB|AAC76553.1 aerobic C4-dicarboxylate transport protein from Escherichia coli
PFams: SDF
428 amino acids: PaperBLAST, CDD, Compare to cluster

DCTA2_PSEAE / Q9I4F5 C4-dicarboxylate transport protein 2 from Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
PFams: SDF
436 amino acids: PaperBLAST, CDD, Compare to cluster

TC 2.A.23.1.6 / P96603 The dicarboxylate (succinate, fumarate, malate and oxaloacetate):H+ symporter, DctA (probably 3H+ are transported per succinate taken up from Bacillus subtilis
PFams: SDF
421 amino acids: PaperBLAST, CDD, Compare to cluster

TC 2.A.23.1.3 / Q01857 C4-dicarboxylate transporter (substrates: fumarate, D- and L-malate, succinate, succinamide, orotate, iticonate, mesaconate) from Rhizobium leguminosarum
PFams: SDF
444 amino acids: PaperBLAST, CDD, Compare to cluster

TC 2.A.23.1.9 / Q1J1H5 Fumarate:H+ symporter of 442 aas and 14 established TMSs, DctA. Responsible for the transport of dicarboxylates such as succinate, fumarate, and malate from Deinococcus geothermalis (strain DSM 11300)
PFams: SDF
442 amino acids: PaperBLAST, CDD, Compare to cluster

TC 2.A.23.1.10 / Q848I3 Organic acid uptake porter, DctA of 444 aas and 8 - 10 putative TMSs from Pseudomonas chlororaphis
PFams: SDF
444 amino acids: PaperBLAST, CDD, Compare to cluster

AO356_18980 sodium:C4-dicarboxylate symporter (dctA) from Pseudomonas fluorescens FW300-N2C3
PFams: SDF
450 amino acids: PaperBLAST, CDD, Compare to cluster