Clusters of Characterized Proteins

Clustering the characterized proteins for dgoK (2-dehydro-3-deoxygalactonokinase) in D-galactose catabolism

Or see other characterized proteins similar to dgoK

Or see all steps for D-galactose catabolism

Or cluster curated proteins matching a keyword

Definition of dgoK

• Curated proteins or TIGRFams with EC 2.7.1.58
• Curated proteins or TIGRFams with EC 2.7.1.178
• Ignore hits to Q9ZU29 when looking for 'other' hits (2-dehydro-3-deoxyglucono/galactono-kinase (EC 2.7.1.178))
• UniProt sequence B2SYR9: SubName: Full=2-keto-3-deoxy-galactonokinase {ECO:0000313|EMBL:ACD17804.1};
• UniProt sequence A0A1I2AR49: SubName: Full=2-dehydro-3-deoxygalactonokinase {ECO:0000313|EMBL:SFE46505.1};
• UniProt sequence D8J0Z3: SubName: Full=2-keto-3-deoxygalactonate kinase protein {ECO:0000313|EMBL:ADJ62548.1}; EC=2.7.1.58 {ECO:0000313|EMBL:ADJ62548.1};
• Comment: BRENDA misannotates Q9zU29 as dgoK. Fitness data confirms diverged dgoK proteins BPHYT_RS16950 (B2SYR9), N515DRAFT_1233 (A0A1I2AR49), and HSERO_RS05160 (D8J0Z3).

Fetched 12 sequences

Running BLASTp

Found similarities, at above 30% identity and 75% coverage, for 11 of these sequences

Found 3 clusters of similar sequences. Another 1 sequences are not clustered. Download as table or as draft rules or view by organism

Cluster 1 292-350 amino acids (not heteromeric)

A6TFZ6 2-dehydro-3-deoxygalactonokinase (EC 2.7.1.58) from Klebsiella pneumoniae
PFams: DGOK
292 amino acids: PaperBLAST, CDD, Compare to cluster

DGOK_RHIME / Q92RN7 Probable 2-dehydro-3-deoxygalactonokinase DgoK1; 2-keto-3-deoxy-galactonokinase; 2-oxo-3-deoxygalactonate kinase; EC 2.7.1.58 from Rhizobium meliloti (strain 1021) (Ensifer meliloti) (Sinorhizobium meliloti)
PFams: DGOK
306 amino acids: PaperBLAST, CDD, Compare to cluster

A0A1I2AR49 2-dehydro-3-deoxygalactonokinase
306 amino acids: PaperBLAST, CDD, Compare to cluster

B2SYR9 2-keto-3-deoxy-galactonokinase
350 amino acids: PaperBLAST, CDD, Compare to cluster

D8J0Z3 2-keto-3-deoxygalactonate kinase protein; EC=2.7.1.58
319 amino acids: PaperBLAST, CDD, Compare to cluster

b3693 2-dehydro-3-deoxygalactonokinase (EC 2.7.1.178; EC 2.7.1.58) from Escherichia coli K-12 substr. MG1655
P31459 2-dehydro-3-deoxygalactonokinase (EC 2.7.1.178) from Escherichia coli (strain K12)
PFams: DGOK
292 amino acids: PaperBLAST, CDD, Compare to cluster

Cluster 2 318-339 amino acids (not heteromeric)

D4GR05 6-phosphofructokinase (EC 2.7.1.11); 2-dehydro-3-deoxyglucono/galactono-kinase (EC 2.7.1.178); 2-dehydro-3-deoxygalactonokinase (EC 2.7.1.58) from Haloferax volcanii
PFams: PfkB
318 amino acids: PaperBLAST, CDD, Compare to cluster

D4GSE6 2-dehydro-3-deoxyglucono/galactono-kinase (EC 2.7.1.178); 2-dehydro-3-deoxygluconokinase (EC 2.7.1.45) from Haloferax volcanii
PFams: PfkB
320 amino acids: PaperBLAST, CDD, Compare to cluster

Q9WXS2 2-keto-3-deoxygluconate kinase (EC 2.7.1.178) from Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
Q9WXS2 2-dehydro-3-deoxygluconokinase (EC 2.7.1.45) from Thermotoga maritima
PFams: PfkB
339 amino acids: PaperBLAST, CDD, Compare to cluster

Cluster 3 309-310 amino acids (not heteromeric)

b3526 2-dehydro-3-deoxygluconokinase (EC 2.7.1.178; EC 2.7.1.45) from Escherichia coli K-12 substr. MG1655
P37647 2-dehydro-3-deoxygluconokinase (EC 2.7.1.178) from Escherichia coli (strain K12)
KDGK_ECOLI / P37647 2-dehydro-3-deoxygluconokinase; 2-keto-3-deoxygluconokinase; 3-deoxy-2-oxo-D-gluconate kinase; KDG kinase; EC 2.7.1.45 from Escherichia coli (strain K12)
PFams: PfkB
309 amino acids: PaperBLAST, CDD, Compare to cluster

P45416 2-dehydro-3-deoxy-D-gluconate kinase (EC 2.7.1.178) from Dickeya dadantii (strain 3937)
KDGK_DICD3 / P45416 2-dehydro-3-deoxygluconokinase; 2-keto-3-deoxygluconokinase; 3-deoxy-2-oxo-D-gluconate kinase; KDG kinase; EC 2.7.1.45 from Dickeya dadantii (strain 3937) (Erwinia chrysanthemi (strain 3937))
PFams: PfkB
310 amino acids: PaperBLAST, CDD, Compare to cluster

Singletons (0/1 heteromeric)

Q97U29 2-dehydro-3-deoxyglucono/2-dehydro-3-deoxygalactonokinase monomer (EC 2.7.1.178) from Saccharolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2)
KDGK_SACS2 / Q97U29 2-dehydro-3-deoxygluconokinase/2-dehydro-3-deoxygalactonokinase; 2-dehydro-3-deoxyglucono/galactono-kinase; 2-keto-3-deoxy-galactonokinase; 2-keto-3-deoxygluconokinase; 3-deoxy-2-oxo-D-gluconate kinase; KDG kinase; KDGal kinase; EC 2.7.1.178 from Saccharolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2) (Sulfolobus solfataricus)
Q97U29 2-dehydro-3-deoxyglucono/galactono-kinase (EC 2.7.1.178) from Saccharolobus solfataricus
PFams: PfkB
313 amino acids: PaperBLAST, CDD