Clusters of Characterized Proteins

GapMind for catabolism of small carbon sources

Clusters of Characterized Proteins

Clustering the characterized proteins for galactonolactonase (galactonolactonase (either 1,4- or 1,5-lactone)) in D-galactose catabolism

Or see other characterized proteins similar to galactonolactonase

Or see all steps for D-galactose catabolism

Or cluster curated proteins matching a keyword

Definition of galactonolactonase

Curated proteins or TIGRFams with EC 3.1.1.25
Ignore hits to A3FJ64 when looking for 'other' hits (N-acyl homoserine lactonase AiiA; AHL-lactonase AiiA; EC 3.1.1.81. quorum-quenching N-acyl-homoserine lactonase (EC 3.1.1.81). 1,4-lactonase (EC 3.1.1.25). quorum-quenching N-acyl-homoserine lactonase (EC 3.1.1.81). quorum-quenching N-acyl-homoserine lactonase (EC 3.1.1.81). N-acyl homoserine lactonase; AHL-lactonase; Homoserine lactone lactonase; EC 3.1.1.81)
Curated sequence BPHYT_RS16915: L-arabinolactonase (EC 3.1.1.15)
UniProt sequence A0A1I2AUG6: SubName: Full=L-arabinonolactonase {ECO:0000313|EMBL:SFE46663.1};
Curated sequence GFF3393: galactaro-1,5-lactonase
Curated sequence PfGW456L13_3314: D-galactono-lactonase (EC 3.1.1.-)
UniProt sequence A0A165IRV8: SubName: Full=Gluconolactonase {ECO:0000313|EMBL:KZT13455.1};
UniProt sequence Q92RN9: RecName: Full=Putative sugar lactone lactonase; EC=3.1.1.-;
Ignore hits to Q92RN9 when looking for 'other' hits (Putative sugar lactone lactonase; EC 3.1.1.-)
Ignore hits to items matching 3.1.1.15 when looking for 'other' hits
Comment: This step includes both galactono-1,4-lactonases (EC 3.1.1.25) and galactono-1-5-lactonases. Some galactonolactonases are also L-arabinolactonases (EC 3.1.1.15), so those are ignored. BRENDA annotates A3FJ64 (from Bacillus thuringensis) as this, which seems questionable. Fitness data confirms diverged lactonases N515DRAFT_1229 (A0A1I2AUG6) and BPHYT_RS16915. PS417_17365 from P. simiae WCS417 (GFF3393) is a galactono-1,5-lactonase, so is not given the EC number. Similarly for PfGW456L13_3314. In Acidovorax sp. GW101-3H11, fitness data suggests that the lactonase is Ac3H11_615 (A0A165IRV8). And fitness data suggests that SMc00883 (Q92RN9) is a galactonolactonase and an arabinonolaconase (it has a vague annotation in SwissProt).

Fetched 20 sequences

Running BLASTp

Found similarities, at above 30% identity and 75% coverage, for 18 of these sequences

Found 4 clusters of similar sequences. Another 2 sequences are not clustered. Download as table or as draft rules or view by organism

Cluster 1 291-316 amino acids (not heteromeric)

BPHYT_RS16915 L-arabinolactonase (EC 3.1.1.15) from Burkholderia phytofirmans PsJN
PFams: SGL
300 amino acids: PaperBLAST, CDD, Compare to cluster

A0A165IRV8 Gluconolactonase
316 amino acids: PaperBLAST, CDD, Compare to cluster

A0A1I2AUG6 L-arabinonolactonase
300 amino acids: PaperBLAST, CDD, Compare to cluster

Q92RN9 Putative sugar lactone lactonase; EC=3.1.1.-
294 amino acids: PaperBLAST, CDD, Compare to cluster

PS417_17365 galactaro-1,5-lactonase from Pseudomonas simiae WCS417
PFams: SGL
291 amino acids: PaperBLAST, CDD, Compare to cluster

AO356_20235 L-arabinolactonase (EC 3.1.1.15) / D-galactonolactonase (EC 3.1.1.25) from Pseudomonas fluorescens FW300-N2C3
PFams: SGL
291 amino acids: PaperBLAST, CDD, Compare to cluster

Cluster 2 354-355 amino acids (not heteromeric)

PON1_HUMAN / P27169 Serum paraoxonase/arylesterase 1; PON 1; Aromatic esterase 1; A-esterase 1; K-45; Serum aryldialkylphosphatase 1; EC 3.1.1.2; EC 3.1.1.81; EC 3.1.8.1 from Homo sapiens (Human)
P27169 arylesterase (EC 3.1.1.2); 1,4-lactonase (EC 3.1.1.25); aryldialkylphosphatase (EC 3.1.8.1) from Homo sapiens
PFams: SGL, Arylesterase, Str_synth
355 amino acids: PaperBLAST, CDD, Compare to cluster

PON1_MOUSE / P52430 Serum paraoxonase/arylesterase 1; PON 1; Aromatic esterase 1; A-esterase 1; Serum aryldialkylphosphatase 1; EC 3.1.1.2; EC 3.1.1.81; EC 3.1.8.1 from Mus musculus (Mouse)
P52430 arylesterase (EC 3.1.1.2); 1,4-lactonase (EC 3.1.1.25); aryldialkylphosphatase (EC 3.1.8.1) from Mus musculus
PFams: SGL, Arylesterase
355 amino acids: PaperBLAST, CDD, Compare to cluster

PON3_HUMAN / Q15166 Serum paraoxonase/lactonase 3; EC 3.1.1.2; EC 3.1.1.81; EC 3.1.8.1 from Homo sapiens (Human)
Q15166 arylesterase (EC 3.1.1.2); 1,4-lactonase (EC 3.1.1.25); aryldialkylphosphatase (EC 3.1.8.1) from Homo sapiens
PFams: SGL, Arylesterase, Str_synth
354 amino acids: PaperBLAST, CDD, Compare to cluster

Q68FP2 arylesterase (EC 3.1.1.2); 1,4-lactonase (EC 3.1.1.25); aryldialkylphosphatase (EC 3.1.8.1) from Rattus norvegicus
PFams: Arylesterase, Str_synth
354 amino acids: PaperBLAST, CDD, Compare to cluster

PON3_RABIT / Q9BGN0 Serum paraoxonase/lactonase 3; EC 3.1.1.2; EC 3.1.1.81; EC 3.1.8.1 from Oryctolagus cuniculus (Rabbit)
Q9BGN0 arylesterase (EC 3.1.1.2); 1,4-lactonase (EC 3.1.1.25); aryldialkylphosphatase (EC 3.1.8.1) from Oryctolagus cuniculus
PFams: Arylesterase, Str_synth
354 amino acids: PaperBLAST, CDD, Compare to cluster

PON2_HUMAN / Q15165 Serum paraoxonase/arylesterase 2; PON 2; Aromatic esterase 2; A-esterase 2; Serum aryldialkylphosphatase 2; EC 3.1.1.2; EC 3.1.1.81 from Homo sapiens (Human)
Q15165 arylesterase (EC 3.1.1.2); 1,4-lactonase (EC 3.1.1.25) from Homo sapiens
PFams: SGL, Arylesterase
354 amino acids: PaperBLAST, CDD, Compare to cluster

Cluster 3 314-315 amino acids (not heteromeric)

C4KKZ9 arylesterase (EC 3.1.1.2); 1,4-lactonase (EC 3.1.1.25); aryldialkylphosphatase (EC 3.1.8.1) from Sulfolobus islandicus
PFams: PTE
314 amino acids: PaperBLAST, CDD, Compare to cluster

F0QXN6 carboxylesterase (EC 3.1.1.1); arylesterase (EC 3.1.1.2); 1,4-lactonase (EC 3.1.1.25); aryldialkylphosphatase (EC 3.1.8.1) from Vulcanisaeta moutnovskia
PFams: PTE
315 amino acids: PaperBLAST, CDD, Compare to cluster

Q4J6Z8 arylesterase (EC 3.1.1.2); 1,4-lactonase (EC 3.1.1.25); aryldialkylphosphatase (EC 3.1.8.1) from Sulfolobus acidocaldarius
PFams: PTE
315 amino acids: PaperBLAST, CDD, Compare to cluster

PHP_SACS2 / Q97VT7 Aryldialkylphosphatase; Paraoxonase; SsoPox; Phosphotriesterase-like lactonase; EC 3.1.8.1 from Saccharolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2) (Sulfolobus solfataricus)
Q97VT7 1,4-lactonase (EC 3.1.1.25); quorum-quenching N-acyl-homoserine lactonase (EC 3.1.1.81); aryldialkylphosphatase (EC 3.1.8.1) from Saccharolobus solfataricus
PFams: PTE
314 amino acids: PaperBLAST, CDD, Compare to cluster

Cluster 4 353-353 amino acids (not heteromeric)

PFLAC_MYCAP / A5IZ80 Phospho-furanose lactonase; EC 3.1.1.25 from Mycoplasma agalactiae (strain PG2)
PFams: PTE
353 amino acids: PaperBLAST, CDD, Compare to cluster

PFLAC_MYCS5 / Q4A724 Phospho-furanose lactonase; EC 3.1.1.25 from Mycoplasma synoviae (strain 53)
PFams: PTE
353 amino acids: PaperBLAST, CDD, Compare to cluster

Singletons (0/2 heteromeric)

B2LYJ5 1,4-lactonase (EC 3.1.1.25) from Fusarium proliferatum
PFams: SGL, Str_synth, Arylesterase
401 amino acids: PaperBLAST, CDD

PfGW456L13_3314 D-galactono-lactonase (EC 3.1.1.-) from Pseudomonas fluorescens GW456-L13
PFams: Lactonase
389 amino acids: PaperBLAST, CDD