Clusters of Characterized Proteins

Clustering the characterized proteins for sglS (sodium/galactose cotransporter) in D-galactose catabolism

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Definition of sglS

• Curated sequence P96169: Sodium/glucose cotransporter; Na(+)/glucose symporter. Glucose or galactose:Na+ symporter, SglS or SglT of 543 aas and 14 TMSs (Turk et al. 2006). The 3.0 Å structure is known (Faham et al., 2008). Sodium exit causes a reorientation of transmembrane helix 1 that opens an inner gate required for substrate exit (Watanabe et al., 2010). The involvement of aromatic residue pi interactions, especially with Na+ binding, has been examined
• UniProt sequence L0FZF3: SubName: Full=SSS sodium solute transporter {ECO:0000313|EMBL:AGA78126.1};
• UniProt sequence A0A1X9Z2P8: SubName: Full=Sodium transporter {ECO:0000313|EMBL:ARS39271.1};
• Comment: Echvi_1871 (L0FZF3) seems to be a glucose/galactose transporter. CA265_RS06130 (A0A1X9Z2P8) seems to be a galactose transporter.

Fetched 3 sequences

Running BLASTp

Found similarities, at above 30% identity and 75% coverage, for 3 of these sequences

Found 1 clusters of similar sequences. Download as table or as draft rules or view by organism

Cluster 1 543-558 amino acids (not heteromeric)

SGLT_VIBPH / P96169 Sodium/glucose cotransporter; Na(+)/glucose symporter from Vibrio parahaemolyticus
TC 2.A.21.3.2 / P96169 Glucose or galactose:Na+ symporter, SglS or SglT of 543 aas and 14 TMSs (Turk et al. 2006). The 3.0 Å structure is known (Faham et al., 2008). Sodium exit causes a reorientation of transmembrane helix 1 that opens an inner gate required for substrate exit (Watanabe et al., 2010). The involvement of aromatic residue pi interactions, especially with Na+ binding, has been examined
PFams: SSF
543 amino acids: PaperBLAST, CDD, Compare to cluster

A0A1X9Z2P8 Sodium transporter
558 amino acids: PaperBLAST, CDD, Compare to cluster

L0FZF3 SSS sodium solute transporter
547 amino acids: PaperBLAST, CDD, Compare to cluster