Clusters of Characterized Proteins

Clustering the characterized proteins for gltX (glutamyl-tRNA(Glx) synthetase) in L-glutamine biosynthesis

Or see other characterized proteins similar to gltX

Or see all steps for L-glutamine biosynthesis

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Definition of gltX

• Curated proteins or TIGRFams with EC 6.1.1.24
• UniProt sequence A0A0H3C8P5_CAUVN: RecName: Full=Glutamate--tRNA ligase {ECO:0000256|HAMAP-Rule:MF_00022}; EC=6.1.1.17 {ECO:0000256|HAMAP-Rule:MF_00022}; AltName: Full=Glutamyl-tRNA synthetase {ECO:0000256|HAMAP-Rule:MF_00022}; Short=GluRS {ECO:0000256|HAMAP-Rule:MF_00022};
• Ignore hits to P00962 when looking for 'other' hits (glutamine-tRNA ligase (EC 6.1.1.18); glutamate-tRNAGln ligase (EC 6.1.1.24). glutaminyl-tRNA synthetase; EC 6.1.1.18. Glutamine--tRNA ligase; Glutaminyl-tRNA synthetase; GlnRS; EC 6.1.1.18. glutamine—tRNA ligase (EC 6.1.1.18). glutamine—tRNA ligase (EC 6.1.1.18))
• Curated sequence Q8DLI5: Glutamate--tRNA ligase; Glutamyl-tRNA synthetase; GluRS; EC 6.1.1.17
• Comment: Glutamyl-tRNA(Glu/Gln) is usually formed by a nondescriminating glutamyl-tRNA synthetase. CCNA_01982 (A0A0H3C8P5_CAUVN) from Caulobacter crescentus is the sole glutamyl-tRNA synthetase, there is no glutaminyl-tRNA synthetase, and gatABC are present, so we annotated it as non-discriminating. In contrast, as of March 2019, unirule UR000075658 labeled it as EC 6.1.1.17 (the discriminating kind). E. coli glutamine-tRNA ligase (P00962) is misannotated in BRENDA as the non-discriminating ligase. Q8DLI5 is a non-discriminating glutamyl-tRNA synthetase (PMID:16876193) but is not given this EC number in SwissProt.

Fetched 6 sequences

Running BLASTp

Found similarities, at above 30% identity and 75% coverage, for 6 of these sequences

Found 1 clusters of similar sequences. Download as table or as draft rules or view by organism

Cluster 1 470-574 amino acids (not heteromeric)

P22250 glutamyl-tRNA^Glx synthetase (EC 6.1.1.17; EC 6.1.1.24) from Bacillus subtilis (strain 168)
PFams: tRNA-synt_1c, Anticodon_2
483 amino acids: PaperBLAST, CDD, Compare to cluster

Q8IDD3 glutamate-tRNAGln ligase (EC 6.1.1.24) from Plasmodium falciparum
PFams: tRNA-synt_1c
574 amino acids: PaperBLAST, CDD, Compare to cluster

Q9X2I8 glutamate-tRNAGln ligase (EC 6.1.1.24) from Thermotoga maritima
PFams: tRNA-synt_1c, tRNA-synt_1c, Anticodon_2
487 amino acids: PaperBLAST, CDD, Compare to cluster

SYE_THEVB / Q8DLI5 Glutamate--tRNA ligase; Glutamyl-tRNA synthetase; GluRS; EC 6.1.1.17 from Thermosynechococcus vestitus (strain NIES-2133 / IAM M-273 / BP-1)
PFams: tRNA-synt_1c, Anticodon_2
485 amino acids: PaperBLAST, CDD, Compare to cluster

A0A0H3C8P5_CAUVN Glutamate--tRNA ligase {ECO:0000256|HAMAP-Rule:MF_00022}; EC=6.1.1.17 {ECO:0000256|HAMAP-Rule:MF_00022}; Glutamyl-tRNA synthetase {ECO:0000256|HAMAP-Rule:MF_00022}; Short=GluRS {ECO:0000256|HAMAP-Rule:MF_00022}
470 amino acids: PaperBLAST, CDD, Compare to cluster

CCNA_01982 glutamyl-tRNA(Glx) synthetase (EC 6.1.1.24) from Caulobacter crescentus NA1000
PFams: tRNA-synt_1c, Anticodon_2
470 amino acids: PaperBLAST, CDD, Compare to cluster