Clusters of Characterized Proteins

Clustering the characterized proteins for nagX (transmembrane glucosamine N-acetyltransferase NagX) in D-glucosamine (chitosamine) catabolism

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Definition of nagX

• UniProt sequence A0KZW6: RecName: Full=DUF5009 domain-containing protein {ECO:0000259|Pfam:PF16401};
• UniProt sequence A1S448: RecName: Full=DUF5009 domain-containing protein {ECO:0000259|Pfam:PF16401};
• UniProt sequence L0FVP4: RecName: Full=DUF1624 domain-containing protein {ECO:0000259|Pfam:PF07786};
• Comment: These NagX proteins are distantly related to human HGSNAT (Q68CP4), which is a transmembrane acetyl-CoA:alpha-glucosaminide N-acetyltransferase. Genetic data suggests that these bacterial homologs are involved in glucosamine utilization, but not as a transporter -- N-acetylglucosamine utilization genes are also involved. So, they appear to be transmembrane N-acetyltransferases for glucosamine. The key histidine which holds the acetyl group as it passes through the membrane (His269 in NG_009552.1, or His297 in Q68CP4) is conserved in these proteins. The bacterial proteins with clear evidence for this role are: Shewana3_3111 (A0KZW6), Sama_0947 (A1S448), and Echvi_1106 (L0FVP4).

Fetched 3 sequences

Running BLASTp

Found similarities, at above 30% identity and 75% coverage, for 3 of these sequences

Found 1 clusters of similar sequences. Download as table or as draft rules or view by organism

Cluster 1 369-395 amino acids (not heteromeric)

A0KZW6 DUF5009 domain-containing protein {ECO:0000259|Pfam:PF16401}
395 amino acids: PaperBLAST, CDD, Compare to cluster

A1S448 DUF5009 domain-containing protein {ECO:0000259|Pfam:PF16401}
378 amino acids: PaperBLAST, CDD, Compare to cluster

L0FVP4 DUF1624 domain-containing protein {ECO:0000259|Pfam:PF07786}
369 amino acids: PaperBLAST, CDD, Compare to cluster