Clusters of Characterized Proteins

GapMind for catabolism of small carbon sources

Clusters of Characterized Proteins

Clustering the characterized proteins for uxuA (D-mannonate dehydratase) in D-glucuronate catabolism

Or see other characterized proteins similar to uxuA

Or see all steps for D-glucuronate catabolism

Or cluster curated proteins matching a keyword

Definition of uxuA

Curated proteins or TIGRFams with EC 4.2.1.8
Ignore hits to A4WA78 when looking for 'other' hits (D-galactonate dehydratase family member Ent638_1932; D-mannonate dehydratase; EC 4.2.1.-; EC 4.2.1.8)
Ignore hits to A5KUH4 when looking for 'other' hits (D-galactonate dehydratase family member VSWAT3_13707)
Ignore hits to A6AMN2 when looking for 'other' hits (D-galactonate dehydratase family member A1Q3065)
Ignore hits to A6M2W4 when looking for 'other' hits (D-galactonate dehydratase family member Cbei_4837)
Ignore hits to A6VRA1 when looking for 'other' hits (D-galactonate dehydratase family member Mmwyl1_0037; D-mannonate dehydratase; EC 4.2.1.-; EC 4.2.1.8)
Ignore hits to A8RQK7 when looking for 'other' hits (D-galactonate dehydratase family member CLOBOL_02770)
Ignore hits to B1ELW6 when looking for 'other' hits (D-galactonate dehydratase family member RspA; D-mannonate dehydratase; Starvation sensing protein RspA homolog; EC 4.2.1.-; EC 4.2.1.8)
Ignore hits to B3PDB1 when looking for 'other' hits (D-galactonate dehydratase family member RspA; D-mannonate dehydratase; Starvation sensing protein RspA homolog; EC 4.2.1.-; EC 4.2.1.8)
Ignore hits to B5GCP6 when looking for 'other' hits (D-galactonate dehydratase family member SSBG_02010)
Ignore hits to B5QBD4 when looking for 'other' hits (D-galactonate dehydratase family member SeV_A0456; D-gluconate dehydratase; EC 4.2.1.-; EC 4.2.1.39)
Ignore hits to B5R541 when looking for 'other' hits (D-galactonate dehydratase family member SEN1436; D-gluconate dehydratase; EC 4.2.1.-; EC 4.2.1.39)
Ignore hits to B5RAG0 when looking for 'other' hits (D-galactonate dehydratase family member RspA; D-mannonate dehydratase; Starvation sensing protein RspA homolog; EC 4.2.1.-; EC 4.2.1.8)
Ignore hits to B8HCK2 when looking for 'other' hits (D-galactonate dehydratase family member Achl_0790)
Ignore hits to C6CBG9 when looking for 'other' hits (D-galactonate dehydratase family member Dd703_0947; D-gluconate dehydratase; D-mannonate dehydratase; EC 4.2.1.-; EC 4.2.1.39; EC 4.2.1.8)
Ignore hits to C6CVY9 when looking for 'other' hits (D-galactonate dehydratase family member Pjdr2_1176)
Ignore hits to C6D9S0 when looking for 'other' hits (D-galactonate dehydratase family member PC1_0802; D-mannonate dehydratase; EC 4.2.1.-; EC 4.2.1.8)
Ignore hits to C6DI84 when looking for 'other' hits (D-galactonate dehydratase family member PC1_4063)
Ignore hits to C7PW26 when looking for 'other' hits (D-galactonate dehydratase family member Caci_4410)
Ignore hits to C8ZZN2 when looking for 'other' hits (D-galactonate dehydratase family member EGBG_01401)
Ignore hits to C9A1P5 when looking for 'other' hits (D-galactonate dehydratase family member EGBG_02030)
Ignore hits to C9CN91 when looking for 'other' hits (D-galactonate dehydratase family member ECAG_02205)
Ignore hits to C9NUM5 when looking for 'other' hits (D-galactonate dehydratase family member VIC002985)
Ignore hits to C9Y5D5 when looking for 'other' hits (D-galactonate dehydratase family member Ctu_1p00430)
Ignore hits to D0KC90 when looking for 'other' hits (D-galactonate dehydratase family member Pecwa_4254)
Ignore hits to D0X4R4 when looking for 'other' hits (D-galactonate dehydratase family member VME_00770)
Ignore hits to D4GJ14 when looking for 'other' hits (D-galactonate dehydratase family member RspA; D-gluconate dehydratase; Starvation sensing protein RspA homolog; EC 4.2.1.-; EC 4.2.1.39)
Ignore hits to D7BPX0 when looking for 'other' hits (D-galactonate dehydratase family member SBI_01856; D-gluconate dehydratase; EC 4.2.1.-; EC 4.2.1.39)
Ignore hits to D8ADB5 when looking for 'other' hits (D-galactonate dehydratase family member RspA; D-mannonate dehydratase; Starvation sensing protein RspA homolog; EC 4.2.1.-; EC 4.2.1.8)
Ignore hits to D9UNB2 when looking for 'other' hits (D-galactonate dehydratase family member SSLG_02014; D-mannonate dehydratase; EC 4.2.1.-; EC 4.2.1.8)
Ignore hits to E1V4Y0 when looking for 'other' hits (D-galactonate dehydratase family member RspA; D-gluconate dehydratase; D-mannonate dehydratase; Starvation sensing protein RspA homolog; EC 4.2.1.-; EC 4.2.1.39; EC 4.2.1.8)
Ignore hits to Q1QT89 when looking for 'other' hits (D-galactonate dehydratase family member ManD; D-gluconate dehydratase; D-mannonate dehydratase; EC 4.2.1.-; EC 4.2.1.39; EC 4.2.1.8)
Ignore hits to Q2CIN0 when looking for 'other' hits (D-galactonate dehydratase family member OG2516_05608)
Ignore hits to Q6DAR4 when looking for 'other' hits (D-galactonate dehydratase family member ECA0189)
Ignore hits to Q8FHC7 when looking for 'other' hits (D-galactonate dehydratase family member RspA; D-mannonate dehydratase; Starvation sensing protein RspA homolog; EC 4.2.1.-; EC 4.2.1.8)
Comment: Many proteins are annotated in SwissProt as "D-galactonate dehydratase family member" but have little activity on D-mannonoate; it is probably not the physiological substrate

Fetched 12 sequences

Running BLASTp

Found similarities, at above 30% identity and 75% coverage, for 12 of these sequences

Found 2 clusters of similar sequences. Download as table or as draft rules or view by organism

Cluster 1 402-419 amino acids (not heteromeric)

MAND2_CAUVC / Q9AAR4 D-mannonate dehydratase CC0532; ManD; EC 4.2.1.8 from Caulobacter vibrioides (strain ATCC 19089 / CB15) (Caulobacter crescentus)
A0A0H3C643 mannonate dehydratase (EC 4.2.1.8) from Caulobacter vibrioides
PFams: MR_MLE_N, MR_MLE_C
403 amino acids: PaperBLAST, CDD, Compare to cluster

MAND_NOVAD / A4XF23 D-mannonate dehydratase; ManD; RspA homolog; EC 4.2.1.8 from Novosphingobium aromaticivorans (strain ATCC 700278 / DSM 12444 / CIP 105152 / NBRC 16084 / F199)
PFams: MR_MLE_N, MR_MLE_C
402 amino acids: PaperBLAST, CDD, Compare to cluster

MAND_SPHWW / A5V6Z0 D-mannonate dehydratase; ManD; EC 4.2.1.8 from Sphingomonas wittichii (strain RW1 / DSM 6014 / JCM 10273)
PFams: MR_MLE_N, MR_MLE_C
402 amino acids: PaperBLAST, CDD, Compare to cluster

MAND1_CAUSK / B0T0B1 D-mannonate dehydratase Caul1427; ManD; EC 4.2.1.8 from Caulobacter sp. (strain K31)
PFams: MR_MLE_N, MR_MLE_C
403 amino acids: PaperBLAST, CDD, Compare to cluster

MAND2_CAUSK / B0T4L2 D-mannonate dehydratase Caul1835; ManD; EC 4.2.1.8 from Caulobacter sp. (strain K31)
PFams: MR_MLE_N, MR_MLE_C
403 amino acids: PaperBLAST, CDD, Compare to cluster

MAND_XANOB / G7TAD9 D-mannonate dehydratase; ManD; EC 4.2.1.8 from Xanthomonas oryzae pv. oryzicola (strain BLS256)
PFams: MR_MLE_N, MR_MLE_C
419 amino acids: PaperBLAST, CDD, Compare to cluster

MAND_SPHSS / Q1NAJ2 D-mannonate dehydratase; ManD; EC 4.2.1.8 from Sphingomonas sp. (strain SKA58)
PFams: MR_MLE_N, MR_MLE_C
403 amino acids: PaperBLAST, CDD, Compare to cluster

MAND1_CAUVC / Q9A4L8 D-mannonate dehydratase CC2812; ManD; EC 4.2.1.8 from Caulobacter vibrioides (strain ATCC 19089 / CB15) (Caulobacter crescentus)
PFams: MR_MLE_N, MR_MLE_C
403 amino acids: PaperBLAST, CDD, Compare to cluster

Cluster 2 360-394 amino acids (not heteromeric)

A4VVI4 mannonate dehydratase (EC 4.2.1.8) from Streptococcus suis
PFams: UxuA, AP_endonuc_2
366 amino acids: PaperBLAST, CDD, Compare to cluster

b4322 D-mannonate dehydratase (EC 4.2.1.8) from Escherichia coli K-12 substr. MG1655
P24215 D-mannonate dehydratase (EC 4.2.1.8) from Escherichia coli (strain K12)
UXUA_ECOLI / P24215 Mannonate dehydratase; D-mannonate hydro-lyase; EC 4.2.1.8 from Escherichia coli (strain K12)
P24215 mannonate dehydratase (EC 4.2.1.8) from Escherichia coli
PFams: UxuA
394 amino acids: PaperBLAST, CDD, Compare to cluster

Q1QT83 mannonate dehydratase (EC 4.2.1.8) from Chromohalobacter salexigens
PFams: UxuA, AP_endonuc_2
391 amino acids: PaperBLAST, CDD, Compare to cluster

Q9WXS4 D-mannonate dehydratase (EC 4.2.1.8) from Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
PFams: UxuA, AP_endonuc_2
360 amino acids: PaperBLAST, CDD, Compare to cluster