Clusters of Characterized Proteins

Clustering the characterized proteins for uxuL (D-glucaro-1,5-lactonase UxuL or UxuF) in D-glucuronate catabolism

Or see other characterized proteins similar to uxuL

Or see all steps for D-glucuronate catabolism

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Definition of uxuL

• UniProt sequence B2UIY8: SubName: Full=SMP-30/Gluconolaconase/LRE domain protein {ECO:0000313|EMBL:ACD29539.1};
• UniProt sequence Q888H2: SubName: Full=Senescence marker protein-30 family protein {ECO:0000313|EMBL:AAO54583.1};
• UniProt sequence A4JG52: SubName: Full=3-carboxymuconate cyclase-like protein {ECO:0000313|EMBL:ABO55255.1};
• UniProt sequence A0A0H3KPX2: SubName: Full=6-phosphogluconolactonase {ECO:0000313|EMBL:BAG44069.1}; EC=3.1.1.31 {ECO:0000313|EMBL:BAG44069.1};
• UniProt sequence Q39EM3: SubName: Full=3-carboxymuconate cyclase-like protein {ECO:0000313|EMBL:ABB09093.1};
• UniProt sequence Q881W7: SubName: Full=Uncharacterized protein {ECO:0000313|EMBL:AAO56265.1};
• UniProt sequence Q88NN7: SubName: Full=Gluconolactonase {ECO:0000313|EMBL:AAN66794.1}; EC=3.1.1.- {ECO:0000313|EMBL:AAN66794.1}; EC=3.1.1.17 {ECO:0000313|EMBL:AAN66794.1};
• Ignore hits to GFF3393 when looking for 'other' hits (galactaro-1,5-lactonase)
• Comment: Biochemical studies showed that lactonases uxuL and uxuF act on D-glucaro-1,5-lactone (PMC6304669). These include Rpic_4446 = B2UIY8, PSPTO_1052 = Q888H2, Bcep1808_2255 = A4JG52, BMULJ_02167 = A0A0H3KPX2, Bcep18194_A5499 = Q39EM3, and PSPTO_2765 = Q881W7, Genetic data from P. putida KT2440 shows that a uxuL-like protein (PP_1170 = Q88NN7) is involved in glucuronate utilization. UxuL/uxuF are also active on galactaro-1,5-lactone, and PS417_17365 from WCS417 may well act on both substrates, but this is not proven.

Fetched 7 sequences

Running BLASTp

Found similarities, at above 30% identity and 75% coverage, for 7 of these sequences

Found 2 clusters of similar sequences. Download as table or as draft rules or view by organism

Cluster 1 348-359 amino acids (not heteromeric)

A0A0H3KPX2 6-phosphogluconolactonase; EC=3.1.1.31
348 amino acids: PaperBLAST, CDD, Compare to cluster

A4JG52 3-carboxymuconate cyclase-like protein
349 amino acids: PaperBLAST, CDD, Compare to cluster

Q39EM3 3-carboxymuconate cyclase-like protein
349 amino acids: PaperBLAST, CDD, Compare to cluster

Q881W7 Uncharacterized protein
359 amino acids: PaperBLAST, CDD, Compare to cluster

Cluster 2 293-300 amino acids (not heteromeric)

B2UIY8 SMP-30/Gluconolaconase/LRE domain protein
300 amino acids: PaperBLAST, CDD, Compare to cluster

Q888H2 Senescence marker protein-30 family protein
294 amino acids: PaperBLAST, CDD, Compare to cluster

Q88NN7 Gluconolactonase; EC=3.1.1.-; EC=3.1.1.17
293 amino acids: PaperBLAST, CDD, Compare to cluster