Clusters of Characterized Proteins

GapMind for catabolism of small carbon sources

Clusters of Characterized Proteins

Clustering the characterized proteins for fumD ((S)-2-methylmalate dehydratase (mesaconase)) in L-glutamate catabolism

Or see other characterized proteins similar to fumD

Or see all steps for L-glutamate catabolism

Or cluster curated proteins matching a keyword

Definition of fumD

Curated proteins or TIGRFams with EC 4.2.1.34
Ignore hits to items matching 4.2.1.2 when looking for 'other' hits
Comment: An enzyme from Burkholderia xenovorans was shown to have a physiologically relevant mesaconase. Many fumarases (EC 4.2.1.2) may have this activity as well, so they are marked ignore.

Fetched 3 sequences

Running BLASTp

Found similarities, at above 30% identity and 75% coverage, for 3 of these sequences

Found 1 clusters of similar sequences. Download as table or as draft rules or view by organism

Cluster 1 520-548 amino acids (not heteromeric)

The first sequence in each cluster is the seed.

b1612 fumarase A (EC 4.2.1.2; EC 5.3.2.2) from Escherichia coli K-12 substr. MG1655
P0AC33 fumarase A (EC 4.2.1.2; EC 5.3.2.2) from Escherichia coli (strain K12)
FUMA_ECOLI / P0AC33 Fumarate hydratase class I, aerobic; Fumarase A; Oxaloacetate keto--enol-isomerase; OAAKE isomerase; Oxaloacetate tautomerase; EC 4.2.1.2; EC 5.3.2.2 from Escherichia coli (strain K12)
P0AC33 fumarate hydratase (EC 4.2.1.2); (S)-2-methylmalate dehydratase (EC 4.2.1.34) from Escherichia coli
CH_021646 fumarate hydratase class I, aerobic; EC 4.2.1.2 from Escherichia coli K12
PFams: Fumerase, Fumerase_C
548 amino acids: PaperBLAST, CDD, Compare to cluster

b4122 fumarase B (EC 4.2.1.2; EC 4.2.1.81) from Escherichia coli K-12 substr. MG1655
P14407 fumarase B (EC 4.2.1.2; EC 4.2.1.81) from Escherichia coli (strain K12)
FUMB_ECOLI / P14407 Fumarate hydratase class I, anaerobic; D-tartrate dehydratase; Fumarase B; EC 4.2.1.2; EC 4.2.1.81 from Escherichia coli (strain K12)
P14407 fumarate hydratase (EC 4.2.1.2); (S)-2-methylmalate dehydratase (EC 4.2.1.34) from Escherichia coli
GB|AAC77083.1 fumarate hydratase class I, anaerobic; EC 4.2.1.2 from Escherichia coli K12
EW|b4122 anaerobic class I fumarate hydratase (fumarase B) from Escherichia coli K12
PFams: Fumerase, Fumerase_C
548 amino acids: PaperBLAST, CDD, Compare to cluster

Q141Z6 fumarate hydratase (EC 4.2.1.2); (S)-2-methylmalate dehydratase (EC 4.2.1.34) from Paraburkholderia xenovorans
PFams: Fumerase, Fumerase_C
520 amino acids: PaperBLAST, CDD, Compare to cluster