Clusters of Characterized Proteins

GapMind for catabolism of small carbon sources

Clusters of Characterized Proteins

Clustering the characterized proteins for gdhA (glutamate dehydrogenase, NAD-dependent) in L-glutamate catabolism

Or see other characterized proteins similar to gdhA

Or see all steps for L-glutamate catabolism

Or cluster curated proteins matching a keyword

Definition of gdhA

Curated proteins or TIGRFams with EC 1.4.1.2
UniProt sequence G8AE86: RecName: Full=Glutamate dehydrogenase {ECO:0000256|ARBA:ARBA00012896}; EC=1.4.1.2 {ECO:0000256|ARBA:ARBA00012896};
Ignore hits to items matching 1.4.1.3 when looking for 'other' hits
Comment: The NADP dependent enzyme acts primarily in the reverse direction, so would not contribute to catabolism. EC 1.4.1.3 describes glutamate dehydrogenases that can use either NAD or NADP; these are ignored. AZOBR_RS00190 (G8AE86) is important for proline and glutamine catabolism, and both are catabolized via glutamate; this confirms it is a glutamate dehydrogenase.

Fetched 29 sequences

Running BLASTp

Found similarities, at above 30% identity and 75% coverage, for 28 of these sequences

Found 3 clusters of similar sequences. Another 1 sequences are not clustered. Download as table or as draft rules or view by organism

Cluster 1 411-458 amino acids (not heteromeric)

DHE2_PYRCJ / A3MUY9 NAD(+)-dependent glutamate dehydrogenase; NAD-GDH; NAD-specific glutamate dehydrogenase; EC 1.4.1.2 from Pyrobaculum calidifontis (strain JCM 11548 / VA1)
A3MUY9 glutamate dehydrogenase (EC 1.4.1.2) from Pyrobaculum calidifontis
PFams: ELFV_dehydrog_N, ELFV_dehydrog
424 amino acids: PaperBLAST, CDD, Compare to cluster

DHE2_CLOSY / P24295 NAD-specific glutamate dehydrogenase; NAD-GDH; EC 1.4.1.2 from Clostridium symbiosum (Bacteroides symbiosus)
P24295 glutamate dehydrogenase (EC 1.4.1.2) from Clostridium symbiosum
PFams: ELFV_dehydrog_N, ELFV_dehydrog
450 amino acids: PaperBLAST, CDD, Compare to cluster

P27346 glutamate dehydrogenase (EC 1.4.1.2) from Clostridioides difficile
GB|AAA62756.1 NAD-specific glutamate dehydrogenase; EC 1.4.1.2 from Clostridium difficile
PFams: ELFV_dehydrog_N, ELFV_dehydrog
421 amino acids: PaperBLAST, CDD, Compare to cluster

Q0E5H9 glutamate dehydrogenase (EC 1.4.1.2) from Halobacillus halophilus
PFams: ELFV_dehydrog_N, ELFV_dehydrog
458 amino acids: PaperBLAST, CDD, Compare to cluster

Q0E5I0 glutamate dehydrogenase (EC 1.4.1.2) from Halobacillus halophilus
PFams: ELFV_dehydrog_N, ELFV_dehydrog
426 amino acids: PaperBLAST, CDD, Compare to cluster

Q38946 glutamate dehydrogenase β subunit (EC 1.4.1.2) from Arabidopsis thaliana
DHE2_ARATH / Q38946 Glutamate dehydrogenase 2; GDH 2; EC 1.4.1.3 from Arabidopsis thaliana (Mouse-ear cress)
Q38946 glutamate dehydrogenase [NAD(P)+] (EC 1.4.1.3) from Arabidopsis thaliana
PFams: ELFV_dehydrog_N, ELFV_dehydrog
411 amino acids: PaperBLAST, CDD, Compare to cluster

Q5QDM6 glutamate dehydrogenase (EC 1.4.1.2) from Lupinus luteus
PFams: ELFV_dehydrog_N, ELFV_dehydrog
411 amino acids: PaperBLAST, CDD, Compare to cluster

Q977U6 glutamate dehydrogenase (EC 1.4.1.2) from Haloferax mediterranei
PFams: ELFV_dehydrog_N, ELFV_dehydrog
441 amino acids: PaperBLAST, CDD, Compare to cluster

Q9TVN3 glutamate dehydrogenase (EC 1.4.1.2) from Entodinium caudatum
PFams: ELFV_dehydrog_N, ELFV_dehydrog
438 amino acids: PaperBLAST, CDD, Compare to cluster

Q9Y8I4 glutamate dehydrogenase (EC 1.4.1.2) from Pyrobaculum islandicum
PFams: ELFV_dehydrog_N, ELFV_dehydrog
421 amino acids: PaperBLAST, CDD, Compare to cluster

P28997 NAD-glutamate dehydrogenase subunit (EC 1.4.1.2) from Peptoniphilus asaccharolyticus
DHE2_PEPAS / P28997 NAD-specific glutamate dehydrogenase; NAD-GDH; EC 1.4.1.2 from Peptoniphilus asaccharolyticus (Peptostreptococcus asaccharolyticus)
P28997 glutamate dehydrogenase (EC 1.4.1.2) from Peptoniphilus asaccharolyticus
PFams: ELFV_dehydrog_N, ELFV_dehydrog
421 amino acids: PaperBLAST, CDD, Compare to cluster

P29051 GdhA (EC 1.4.1.4) from Halobacterium salinarum
DHE2_HALSI / P29051 NAD-specific glutamate dehydrogenase A; NAD-GDH A; EC 1.4.1.2 from Halobacterium salinarum (Halobacterium halobium)
P29051 glutamate dehydrogenase (EC 1.4.1.2) from Halobacterium salinarum
GB|AAW19068.1 glutamate dehydrogenase; EC 1.4.1.2 from Halobacterium salinarum
PFams: ELFV_dehydrog_N, ELFV_dehydrog
435 amino acids: PaperBLAST, CDD, Compare to cluster

DHE2_BACSU / P39633 Catabolic NAD-specific glutamate dehydrogenase RocG; NAD-GDH; Glutamate dehydrogenase; GlutDH; Trigger enzyme RocG; EC 1.4.1.2 from Bacillus subtilis (strain 168)
PFams: ELFV_dehydrog_N, ELFV_dehydrog
424 amino acids: PaperBLAST, CDD, Compare to cluster

GUDB_BACSU / P50735 Cryptic catabolic NAD-specific glutamate dehydrogenase GudB; NAD-GDH; EC 1.4.1.2 from Bacillus subtilis (strain 168)
PFams: ELFV_dehydrog_N, ELFV_dehydrog
427 amino acids: PaperBLAST, CDD, Compare to cluster

DHE1_ORYSJ / Q852M0 Glutamate dehydrogenase 1, mitochondrial; OsGDH1; EC 1.4.1.3 from Oryza sativa subsp. japonica (Rice)
Q852M0 glutamate dehydrogenase (EC 1.4.1.2) from Oryza sativa
PFams: ELFV_dehydrog_N, ELFV_dehydrog
411 amino acids: PaperBLAST, CDD, Compare to cluster

P93541 glutamate dehydrogenase (EC 1.4.1.3) from Solanum lycopersicum
P93541 glutamate dehydrogenase (EC 1.4.1.2) from Solanum lycopersicum
PFams: ELFV_dehydrog_N, ELFV_dehydrog
412 amino acids: PaperBLAST, CDD, Compare to cluster

Cluster 2 1594-1653 amino acids (not heteromeric)

A0A0H3C571 glutamate dehydrogenase (EC 1.4.1.2) from Caulobacter vibrioides
PFams: Bac_GDH
1607 amino acids: PaperBLAST, CDD, Compare to cluster

DHE2_MYCS2 / A0R1C2 NAD-specific glutamate dehydrogenase; NAD-GDH; NAD(+)-dependent glutamate dehydrogenase; EC 1.4.1.2 from Mycolicibacterium smegmatis (strain ATCC 700084 / mc(2)155) (Mycobacterium smegmatis)
A0R1C2 glutamate dehydrogenase (EC 1.4.1.2) from Mycolicibacterium smegmatis
PFams: Bac_GDH
1594 amino acids: PaperBLAST, CDD, Compare to cluster

Q8CJY0 glutamate dehydrogenase (EC 1.4.1.2) from Streptomyces coelicolor
PFams: Bac_GDH
1653 amino acids: PaperBLAST, CDD, Compare to cluster

DHE2_HALED / E1V4J5 NAD-specific glutamate dehydrogenase; NAD-GDH; NAD(+)-dependent glutamate dehydrogenase; EC 1.4.1.2 from Halomonas elongata (strain ATCC 33173 / DSM 2581 / NBRC 15536 / NCIMB 2198 / 1H9)
PFams: Bac_GDH
1613 amino acids: PaperBLAST, CDD, Compare to cluster

DHE2_MYCTU / O53203 NAD-specific glutamate dehydrogenase; NAD-GDH; NAD(+)-dependent glutamate dehydrogenase; EC 1.4.1.2 from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
PFams: Bac_GDH
1624 amino acids: PaperBLAST, CDD, Compare to cluster

DHE2_PSEAE / Q9HZE0 NAD-specific glutamate dehydrogenase; NAD-GDH; NAD(+)-dependent glutamate dehydrogenase; EC 1.4.1.2 from Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
PFams: Bac_GDH
1620 amino acids: PaperBLAST, CDD, Compare to cluster

G8AE86 Glutamate dehydrogenase; EC=1.4.1.2
1618 amino acids: PaperBLAST, CDD, Compare to cluster

Psest_1944 NAD-specific glutamate dehydrogenase (EC 1.4.1.2), large form from Pseudomonas stutzeri RCH2
PFams: Bac_GDH
1616 amino acids: PaperBLAST, CDD, Compare to cluster

Cluster 3 1042-1106 amino acids (not heteromeric)

DHE2_YEAST / P33327 NAD-specific glutamate dehydrogenase; NAD-GDH; EC 1.4.1.2 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
P33327 glutamate dehydrogenase (EC 1.4.1.2) from Saccharomyces cerevisiae
PFams: Bac_GDH, ELFV_dehydrog
1092 amino acids: PaperBLAST, CDD, Compare to cluster

CH_122231 NAD dependent glutamate dehydrogenase; EC 1.4.1.2 from Emericella nidulans
PFams: Bac_GDH, ELFV_dehydrog
1086 amino acids: PaperBLAST, CDD, Compare to cluster

GLUD2_DICDI / Q54VI3 Glutamate dehydrogenase 2; NAD-specific glutamate dehydrogenase; NAD-GDH; EC 1.4.1.2 from Dictyostelium discoideum (Slime mold)
PFams: Bac_GDH, ELFV_dehydrog, Bac_GDH
1042 amino acids: PaperBLAST, CDD, Compare to cluster

GDH2_SCHPO / Q9USN5 Probable NAD-specific glutamate dehydrogenase; NAD-GDH; EC 1.4.1.2 from Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
PFams: Bac_GDH, ELFV_dehydrog
1106 amino acids: PaperBLAST, CDD, Compare to cluster

Singletons (0/1 heteromeric)

DHE3_BOVIN / P00366 Glutamate dehydrogenase 1, mitochondrial; GDH 1; EC 1.4.1.3 from Bos taurus (Bovine)
P00366 glutamate dehydrogenase (EC 1.4.1.2) from Bos taurus
PFams: ELFV_dehydrog_N, ELFV_dehydrog
558 amino acids: PaperBLAST, CDD