Clusters of Characterized Proteins

Clustering the characterized proteins for gltL (L-glutamate ABC transporter, ATPase component (GltL/GluA/BztD/GlnQ/AatP/PEB1C)) in L-glutamate catabolism

Or see other characterized proteins similar to gltL

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Definition of gltL

• Curated sequence A3ZI83: PEB1C, component of Uptake system for glutamate and aspartate
• Curated sequence P0AAG3: Glutamate/aspartate transport ATP-binding protein GltL aka B0652, component of Glutamate/aspartate porter. glutamate/aspartate ABC transporter ATP binding subunit (EC 7.4.2.1). glutamate/aspartate ABC transporter ATP binding subunit (EC 7.4.2.1)
• Curated sequence P48243: GluA aka CGL1950, component of Glutamate porter
• Curated sequence Q52666: BztD, component of Glutamate/glutamine/aspartate/asparagine porter
• Curated sequence Q88NY5: PP1068, component of Acidic amino acid uptake porter, AatJMQP
• Curated sequence Q9CES4: Glutamine ABC transporter ATP-binding protein, component of Glutamine transporter, GlnQP. Takes up glutamine, asparagine and glutamate which compete for each other for binding both substrate and the transmembrane protein constituent of the system (Fulyani et al. 2015). Tandem substrate binding domains (SBDs) differ in substrate specificity and affinity, allowing cells to efficiently accumulate different amino acids via a single ABC transporter. Analysis revealed the roles of individual residues in determining the substrate affinity
• Curated sequence Pf1N1B4_774: ABC transporter for L-asparagine and L-glutamate, ATPase component
• Curated sequence AO353_16275: ABC transporter for L-aspartate, L-asparagine, L-glutamate, and L-glutamine, ATPase component
• Curated sequence Q9I405: Amino acid ABC transporter ATP binding protein, component of Amino acid transporter, AatJMQP. Probably transports L-glutamic acid, D-glutamine acid, L-glutamine and N-acetyl L-glutamic acid (Johnson et al. 2008). Very similar to 3.A.1.3.19 of P. putida
• Ignore hits to PfGW456L13_4773 when looking for 'other' hits (ABC transporter for L-Asparagine and possibly other L-amino acids, putative ATPase component)
• Ignore hits to SMc02121 when looking for 'other' hits (ABC transporter for L-Glutamine, L-Histidine, and other L-amino acids, ATPase component)
• Ignore hits to Q52815 when looking for 'other' hits (AapP, component of General L-amino acid porter; transports basic and acidic amino acids preferentially, but also transports aliphatic amino acids (catalyzes both uptake and efflux))
• Comment: SMc02121 is quite similar and is the ATPase component of a putative amino acid transporter, so it is ignored. Similarly for Q52815

Fetched 9 sequences

Running BLASTp

Found similarities, at above 30% identity and 75% coverage, for 9 of these sequences

Found 1 clusters of similar sequences. Download as table or as draft rules or view by organism

Cluster 1 241-263 amino acids (heteromeric)

TC 3.A.1.3.16 / A3ZI83 PEB1C, component of Uptake system for glutamate and aspartate from Campylobacter jejuni subsp. jejuni 84-25
PFams: ABC_tran, SMC_N
Heteromeric, 242 amino acids: PaperBLAST, CDD, Compare to cluster

b0652 glutamate/aspartate ABC transporter ATP binding subunit (EC 7.4.2.1) from Escherichia coli K-12 substr. MG1655
P0AAG3 glutamate/aspartate ABC transporter ATP binding subunit (EC 7.4.2.1) from Escherichia coli (strain K12)
TC 3.A.1.3.4 / P0AAG3 Glutamate/aspartate transport ATP-binding protein GltL aka B0652, component of Glutamate/aspartate porter from Escherichia coli
PFams: ABC_tran
Heteromeric, 241 amino acids: PaperBLAST, CDD, Compare to cluster

TC 3.A.1.3.9 / P48243 GluA aka CGL1950, component of Glutamate porter from Corynebacterium glutamicum (Brevibacterium flavum)
PFams: ABC_tran
Heteromeric, 242 amino acids: PaperBLAST, CDD, Compare to cluster

TC 3.A.1.3.7 / Q52666 BztD, component of Glutamate/glutamine/aspartate/asparagine porter from Rhodobacter capsulatus (Rhodopseudomonas capsulata)
PFams: ABC_tran
Heteromeric, 263 amino acids: PaperBLAST, CDD, Compare to cluster

TC 3.A.1.3.19 / Q88NY5 PP1068, component of Acidic amino acid uptake porter, AatJMQP from Pseudomonas putida (strain KT2440)
PFams: ABC_tran
Heteromeric, 256 amino acids: PaperBLAST, CDD, Compare to cluster

TC 3.A.1.3.25 / Q9CES4 Glutamine ABC transporter ATP-binding protein, component of Glutamine transporter, GlnQP. Takes up glutamine, asparagine and glutamate which compete for each other for binding both substrate and the transmembrane protein constituent of the system (Fulyani et al. 2015). Tandem substrate binding domains (SBDs) differ in substrate specificity and affinity, allowing cells to efficiently accumulate different amino acids via a single ABC transporter. Analysis revealed the roles of individual residues in determining the substrate affinity from Lactococcus lactis subsp. lactis (strain IL1403)
PFams: SMC_N, ABC_tran
Heteromeric, 247 amino acids: PaperBLAST, CDD, Compare to cluster

TC 3.A.1.3.22 / Q9I405 Amino acid ABC transporter ATP binding protein, component of Amino acid transporter, AatJMQP. Probably transports L-glutamic acid, D-glutamine acid, L-glutamine and N-acetyl L-glutamic acid (Johnson et al. 2008). Very similar to 3.A.1.3.19 of P. putida from Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228)
PFams: ABC_tran
Heteromeric, 244 amino acids: PaperBLAST, CDD, Compare to cluster

Pf1N1B4_774 ABC transporter for L-asparagine and L-glutamate, ATPase component from Pseudomonas fluorescens FW300-N1B4
PFams: ABC_tran
Heteromeric, 244 amino acids: PaperBLAST, CDD, Compare to cluster

AO353_16275 ABC transporter for L-aspartate, L-asparagine, L-glutamate, and L-glutamine, ATPase component from Pseudomonas fluorescens FW300-N2E3
PFams: ABC_tran
Heteromeric, 244 amino acids: PaperBLAST, CDD, Compare to cluster