Clusters of Characterized Proteins

GapMind for Amino acid biosynthesis

Clusters of Characterized Proteins

Clustering the characterized proteins for aceA (isocitrate lyase) in glycine biosynthesis

Or see other characterized proteins similar to aceA

Or see all steps for glycine biosynthesis

Or cluster curated proteins matching a keyword

Definition of aceA

Curated proteins or TIGRFams with EC 4.1.3.1
Curated sequence CH_123497: Isocitrate lyase
Ignore hits to Q05957 when looking for 'other' hits (isocitrate lyase (EC 4.1.3.1). Petal death protein; (R)-2-methylmalate lyase; D-citramalate lyase; Oxalacetic hydrolase; PSR132; EC 3.7.1.1; EC 4.1.3.-)
Ignore hits to P28467 when looking for 'other' hits (Isocitrate lyase; ICL; Isocitrase; Isocitratase; EC 4.1.3.1. isocitrate lyase; EC 4.1.3.1)
Comment: CH_123497 is isocitrate lyase but is annotated without the EC number. Q05957 is misannotated in BRENDA as this function; it prefers other substrates (PMID:16342929) P28467 is annotated as this by two resources but is only 15 amino acids, so it is ignored.

Fetched 41 sequences

Running BLASTp

Found similarities, at above 30% identity and 75% coverage, for 39 of these sequences

Found 3 clusters of similar sequences. Another 2 sequences are not clustered. Download as table or as draft rules or view by organism

Cluster 1 518-766 amino acids (not heteromeric)

ACEA_MAGO7 / P0CT06 Isocitrate lyase; ICL; Isocitrase; Isocitratase; Methylisocitrate lyase; MICA; Threo-D(S)-isocitrate glyoxylate-lyase; EC 4.1.3.1; EC 4.1.3.30 from Magnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958) (Rice blast fungus) (Pyricularia oryzae)
P0CT06 isocitrate lyase (EC 4.1.3.1) from Pyricularia oryzae
CH_124286 isocitrate lyase from Magnaporthe grisea 70-15
PFams: ICL, PEP_mutase
547 amino acids: PaperBLAST, CDD, Compare to cluster

Q4HYR2 isocitrate lyase (EC 4.1.3.1) from Fusarium graminearum
PFams: ICL, PEP_mutase
546 amino acids: PaperBLAST, CDD, Compare to cluster

Q5YLB6 isocitrate lyase (EC 4.1.3.1) from Paracoccidioides brasiliensis
PFams: ICL, PEP_mutase
537 amino acids: PaperBLAST, CDD, Compare to cluster

Q9P8Q7 isocitrate lyase (EC 4.1.3.1) from Candida albicans
PFams: ICL, PEP_mutase
550 amino acids: PaperBLAST, CDD, Compare to cluster

GI|61657961 methylisocitrate lyase precursor; EC 4.1.3.30 from Emericella nidulans
CH_122270 methylisocitrate lyase; EC 4.1.3.30 (from HMM only) from Emericella nidulans
PFams: ICL
604 amino acids: PaperBLAST, CDD, Compare to cluster

ACEA_EMENI / P28298 Isocitrate lyase; ICL; Isocitrase; Isocitratase; Methylisocitrate lyase; MICA; Threo-D(S)-isocitrate glyoxylate-lyase; EC 4.1.3.1; EC 4.1.3.30 from Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
PDB|1DQU_A isocitrate lyase; EC 4.1.3.1 from Emericella nidulans
PFams: ICL, PEP_mutase
538 amino acids: PaperBLAST, CDD, Compare to cluster

CH_123497 Isocitrate lyase from Candida albicans
PFams: ICL, PEP_mutase
550 amino acids: PaperBLAST, CDD, Compare to cluster

ACEB_EMENI / C8V9Y5 Methylisocitrate lyase, mitochondrial; 2-methylisocitrate lyase, mitochondrial; EC 4.1.3.30 (from HMM only) from Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
PFams: ICL
610 amino acids: PaperBLAST, CDD, Compare to cluster

ACEB_HYPAI / G9NNY7 2-methylisocitrate lyase, mitochondrial; EC 4.1.3.30 (from HMM only) from Hypocrea atroviridis (strain ATCC 20476 / IMI 206040) (Trichoderma atroviride)
PFams: ICL, PEP_mutase
561 amino acids: PaperBLAST, CDD, Compare to cluster

ACEA2_MYCTE / H8F3R6 Isocitrate lyase 2; ICL2; Isocitrase; Isocitratase; Methylisocitrate lyase; MICA; EC 4.1.3.1; EC 4.1.3.30 from Mycobacterium tuberculosis (strain ATCC 35801 / TMC 107 / Erdman)
ACEA2_MYCTO / Q8VJU4 Isocitrate lyase 2; ICL2; Isocitrase; Isocitratase; EC 4.1.3.1 from Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)
PFams: ICL, PEP_mutase, ICL
766 amino acids: PaperBLAST, CDD, Compare to cluster

ACEA_BRANA / P25248 Isocitrate lyase; ICL; Isocitrase; Isocitratsysase; EC 4.1.3.1 from Brassica napus (Rape)
PFams: ICL, PEP_mutase
576 amino acids: PaperBLAST, CDD, Compare to cluster

ACEA_YEAST / P28240 Isocitrate lyase; ICL; Methylisocitrate lyase; MICA; Threo-D(S)-isocitrate glyoxylate-lyase; EC 4.1.3.1; EC 4.1.3.30 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
PFams: ICL, PEP_mutase
557 amino acids: PaperBLAST, CDD, Compare to cluster

P28297 isocitrate lyase (EC 4.1.3.1) from Arabidopsis thaliana
ACEA_ARATH / P28297 Isocitrate lyase; ICL; Isocitrase; Isocitratsysase; EC 4.1.3.1 from Arabidopsis thaliana (Mouse-ear cress)
PFams: ICL, PEP_mutase
576 amino acids: PaperBLAST, CDD, Compare to cluster

ACEA_NEUCR / P28299 Isocitrate lyase; ICL; Isocitrase; Isocitratase; Methylisocitrate lyase; MICA; Threo-D(S)-isocitrate glyoxylate-lyase; EC 4.1.3.1; EC 4.1.3.30 from Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
PFams: ICL, PEP_mutase
548 amino acids: PaperBLAST, CDD, Compare to cluster

ACEA_YARLI / P41555 Isocitrate lyase; ICL; Isocitrase; Isocitratase; Methylisocitrate lyase; MICA; Threo-D(S)-isocitrate glyoxylate-lyase; EC 4.1.3.1; EC 4.1.3.30 from Yarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica)
PFams: ICL, PEP_mutase
540 amino acids: PaperBLAST, CDD, Compare to cluster

ACEB_YEAST / Q12031 Mitochondrial 2-methylisocitrate lyase ICL2; Methylisocitrate lyase; EC 4.1.3.30 (from HMM only) from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
PFams: ICL
575 amino acids: PaperBLAST, CDD, Compare to cluster

ACEB_YARLI / Q6BZP5 2-methylisocitrate lyase, mitochondrial; EC 4.1.3.30 (from HMM only) from Yarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica)
PFams: ICL
565 amino acids: PaperBLAST, CDD, Compare to cluster

ACEA_ORYSJ / Q6Z6M4 Isocitrate lyase; ICL; Isocitrase; Isocitratase; EC 4.1.3.1 from Oryza sativa subsp. japonica (Rice)
PFams: ICL, PEP_mutase
572 amino acids: PaperBLAST, CDD, Compare to cluster

ACEA_LEPMC / Q86ZF1 Isocitrate lyase; ICL; Isocitrase; Isocitratase; Methylisocitrate lyase; MICA; Threo-D(S)-isocitrate glyoxylate-lyase; EC 4.1.3.1; EC 4.1.3.30 from Leptosphaeria maculans (Blackleg fungus) (Phoma lingam)
PFams: ICL, PEP_mutase
537 amino acids: PaperBLAST, CDD, Compare to cluster

ACEA_KLULA / Q8NJ72 Isocitrate lyase; ICL; Isocitrase; Isocitratase; Methylisocitrate lyase; MICA; Threo-D(S)-isocitrate glyoxylate-lyase; EC 4.1.3.1; EC 4.1.3.30 from Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica)
PFams: ICL, PEP_mutase
542 amino acids: PaperBLAST, CDD, Compare to cluster

ACEB_SCHPO / Q9P6J1 Mitochondrial 2-methylisocitrate lyase; Methylisocitrate lyase; EC 4.1.3.30 (from HMM only) from Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
PFams: ICL
518 amino acids: PaperBLAST, CDD, Compare to cluster

Cluster 2 428-528 amino acids (not heteromeric)

ACEA_CORGL / P42449 Isocitrate lyase; ICL; Isocitrase; Isocitratase; EC 4.1.3.1 from Corynebacterium glutamicum (strain ATCC 13032 / DSM 20300 / BCRC 11384 / JCM 1318 / LMG 3730 / NCIMB 10025)
PFams: ICL, PEP_mutase, ICL
432 amino acids: PaperBLAST, CDD, Compare to cluster

A0A3S5YB92 isocitrate lyase (EC 4.1.3.1) from Rhodococcus hoagii
PFams: ICL, PEP_mutase, ICL
429 amino acids: PaperBLAST, CDD, Compare to cluster

A8C5K8 isocitrate lyase (EC 4.1.3.1) from Colwellia psychrerythraea
PFams: ICL, PEP_mutase, ICL, ICL
528 amino acids: PaperBLAST, CDD, Compare to cluster

P9WKK7 isocitrate lyase subunit (EC 4.1.3.1) from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
ACEA1_MYCTE / H8EVV4 Isocitrate lyase 1; ICL1; Isocitrase; Isocitratase; Methylisocitrate lyase; MICA; EC 4.1.3.1; EC 4.1.3.30 from Mycobacterium tuberculosis (strain ATCC 35801 / TMC 107 / Erdman)
ACEA1_MYCBO / P0A5H4 Isocitrate lyase 1; ICL1; Isocitrase; Isocitratase; EC 4.1.3.1 from Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97)
ACEA1_MYCTO / P9WKK6 Isocitrate lyase 1; ICL1; Isocitrase; Isocitratase; Methylisocitrate lyase; MICA; EC 4.1.3.1; EC 4.1.3.30 from Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)
ACEA_MYCTU / P9WKK7 Isocitrate lyase; ICL; Isocitrase; Isocitratase; EC 4.1.3.1 from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
P9WKK7 isocitrate lyase (EC 4.1.3.1) from Mycobacterium tuberculosis
PFams: ICL, PEP_mutase, ICL
428 amino acids: PaperBLAST, CDD, Compare to cluster

Q8RPZ0 isocitrate lyase (EC 4.1.3.1) from Streptomyces clavuligerus
PFams: ICL, PEP_mutase, ICL
436 amino acids: PaperBLAST, CDD, Compare to cluster

Q93R40 isocitrate lyase (EC 4.1.3.1) from Colwellia maris
PFams: ICL, PEP_mutase, ICL, ICL
528 amino acids: PaperBLAST, CDD, Compare to cluster

Q97YI8 isocitrate lyase (EC 4.1.3.1) from Saccharolobus solfataricus
PFams: ICL, PEP_mutase, ICL
437 amino acids: PaperBLAST, CDD, Compare to cluster

b4015 isocitrate lyase (EC 4.1.3.1) from Escherichia coli K-12 substr. MG1655
P0A9G6 isocitrate lyase (EC 4.1.3.1) from Escherichia coli (strain K12)
ACEA_ECOLI / P0A9G6 Isocitrate lyase; ICL; Isocitrase; Isocitratase; EC 4.1.3.1 from Escherichia coli (strain K12)
PFams: ICL, PEP_mutase, ICL
434 amino acids: PaperBLAST, CDD, Compare to cluster

BWI76_RS01665 Isocitrate lyase (EC 4.1.3.1) from Klebsiella michiganensis M5al
PFams: ICL, PEP_mutase, ICL
434 amino acids: PaperBLAST, CDD, Compare to cluster

SO1484 Isocitrate lyase (EC 4.1.3.1) from Shewanella oneidensis MR-1
PFams: ICL, PEP_mutase, ICL
440 amino acids: PaperBLAST, CDD, Compare to cluster

Shew_1276 Isocitrate lyase (EC 4.1.3.1) from Shewanella loihica PV-4
PFams: ICL, PEP_mutase, ICL
450 amino acids: PaperBLAST, CDD, Compare to cluster

Sama_2380 Isocitrate lyase (EC 4.1.3.1) from Shewanella amazonensis SB2B
PFams: ICL, PEP_mutase, ICL
439 amino acids: PaperBLAST, CDD, Compare to cluster

Ac3H11_2831 Isocitrate lyase (EC 4.1.3.1) from Acidovorax sp. GW101-3H11
PFams: ICL, PEP_mutase, ICL
443 amino acids: PaperBLAST, CDD, Compare to cluster

Pf1N1B4_4042 Isocitrate lyase (EC 4.1.3.1) from Pseudomonas fluorescens FW300-N1B4
PFams: ICL, PEP_mutase, ICL
441 amino acids: PaperBLAST, CDD, Compare to cluster

Cluster 3 531-540 amino acids (not heteromeric)

A8C781 isocitrate lyase (EC 4.1.3.1) from Azotobacter vinelandii
PFams: ICL, PEP_mutase, ICL, ICL
531 amino acids: PaperBLAST, CDD, Compare to cluster

Q9I0K4 isocitrate lyase (EC 4.1.3.1) from Pseudomonas aeruginosa
PFams: ICL, PEP_mutase, ICL, ICL
531 amino acids: PaperBLAST, CDD, Compare to cluster

ACEA_HYPME / O50078 Isocitrate lyase; ICL; Isocitrase; Isocitratase; EC 4.1.3.1 from Hyphomicrobium methylovorum
PFams: ICL, PEP_mutase, ICL, ICL
540 amino acids: PaperBLAST, CDD, Compare to cluster

Psest_2014 Isocitrate lyase (EC 4.1.3.1) from Pseudomonas stutzeri RCH2
PFams: ICL, PEP_mutase, ICL, ICL
531 amino acids: PaperBLAST, CDD, Compare to cluster

Singletons (0/2 heteromeric)

ACEA_HALVD / D4GTL3 Isocitrate lyase; ICL; Isocitrase; Isocitratase; EC 4.1.3.1 from Haloferax volcanii (strain ATCC 29605 / DSM 3757 / JCM 8879 / NBRC 14742 / NCIMB 2012 / VKM B-1768 / DS2) (Halobacterium volcanii)
PFams: PEP_mutase, ICL, ICL
345 amino acids: PaperBLAST, CDD

GCP_CAEEL / Q10663 Bifunctional glyoxylate cycle protein; Gex-3-interacting protein 7; EC 4.1.3.1; EC 2.3.3.9 from Caenorhabditis elegans
PFams: ICL, PEP_mutase, ICL, MS_N, MS_TIM-barrel, MS_C
968 amino acids: PaperBLAST, CDD