Clusters of Characterized Proteins

GapMind for catabolism of small carbon sources

Clusters of Characterized Proteins

Clustering the characterized proteins for glpF (glycerol facilitator glpF) in glycerol catabolism

Or see other characterized proteins similar to glpF

Or see all steps for glycerol catabolism

Or cluster curated proteins matching a keyword

Definition of glpF

Curated sequence CH_024677: aquaglyceroporin. Glycerol uptake facilitator protein; Aquaglyceroporin. Glycerol facilitator, GlpF. Transports various polyols with decreasing rates as size increases (Heller et al. 1980); also transports arsenite (As(III) and antimonite (Sb(III)) (Meng et al., 2004). Oligomerization may play a role in determining the rate of transport. glycerol facilitator. glycerol facilitator
Curated sequence CH_091207: aquaporin-9. Aquaporin-9; AQP-9; Aquaglyceroporin-9. Aquaporin-9 (Aqp9) (permeable to glycerol, urea, polyols, carbamides, purines, pyrmidines, nucleosides, monocarboxylates, pentavalent methylated arsenicals and the arsenic chemotherapeutic drug, trisenox
Curated sequence CH_091783: aquaglyceroporin 1. Aquaporin 1 (permeable to water, glycerol, dihydroxyacetone and urea)
Curated sequence F9UMX3: Glycerol uptake facilitator protein 4; D/L-lactic acid transporter; Lactic acid channel
Curated sequence F9UST3: D/L-lactic acid transporter; Lactate racemization operon protein LarD; Lactic acid channel. GlpF1; transports water, dihydroxyacetone and glycerol as well as D,L-lactic acid
Curated sequence F9USY3: Glycerol uptake facilitator protein 2. GlpF2
Curated sequence F9UTW9: Glycerol uptake facilitator protein 3. GlpF3
Curated sequence F9UUB3: Glycerol uptake facilitator protein-like 5. GlpF4. Transports water, dihydroxyacetone and glycerol as well as D,L-lactic acid
Curated sequence P47862: Aquaporin-3; AQP-3; 31.4 kDa water channel protein; Aquaglyceroporin-3. Aquaporin 3. 95% identical to the human orthologue. Poorly permeable to water, but more permeable to glycerol and arsenic trioxide
Curated sequence F6QEC2: Aquaporin/glycerol facilitator of 294 aas and 6 TMSs
Curated sequence P08995: Nodulin-26 aquaporin and glycerol facilitator, NIP (de Paula Santos Martins et al. 2015). Transports NH3 5-fold better than water in Hg2+-sensitive fashion
Curated sequence P18156: Glycerol facilitator
Curated sequence P52280: Probable glycerol uptake facilitator protein
Curated sequence Q6Q1Q6: Major aquaglyceroporin, LmAQP1: transports water, glycerol, methylglyoxal, trivalent metalloids such as arsenite and antimonite, dihydroxyacetone and sugar alcohols. Also takes up the activated form or the drug, pentostam
Curated sequence Q8WPZ6: Aquaglycerolporin, Aqp (high permeability to ammonium, methylamine, glycerol and water) (Beitz et al., 2004) NH4+/NH3+CH3 transporter
Curated sequence Q9C4Z5: Hg2+-inhibitable aquaporin, AqpM (transports both water and glycerol as well as CO2) (Kozono et al., 2003; Araya-Secchi et al., 2011). Its 3-d structure has been determined to 1.7 Å. In AqpM, isoleucine replaces a key histidine residue found in the lumen of water channels, which becomes a glycine residue in aquaglyceroporins. As a result of this and other side-chain substituents in the walls of the channel, the channel is intermediate in size and exhibits differentially tuned electrostatics when compared with the other subfamilies
Ignore hits to O28846 when looking for 'other' hits (MIP family homologue)
Comment: Ignore an uncharacterized homolog from Archaeoglobus

Fetched 16 sequences

Running BLASTp

Found similarities, at above 30% identity and 75% coverage, for 16 of these sequences

Found 1 clusters of similar sequences. Download as table or as draft rules or view by organism

Cluster 1 235-321 amino acids (not heteromeric)

The first sequence in each cluster is the seed.

b3927 glycerol facilitator from Escherichia coli K-12 substr. MG1655
P0AER0 glycerol facilitator from Escherichia coli (strain K12)
GLPF_ECOLI / P0AER0 Glycerol uptake facilitator protein; Aquaglyceroporin from Escherichia coli (strain K12)
TC 1.A.8.1.1 / P0AER0 Glycerol facilitator, GlpF. Transports various polyols with decreasing rates as size increases (Heller et al. 1980); also transports arsenite (As(III) and antimonite (Sb(III)) (Meng et al., 2004). Oligomerization may play a role in determining the rate of transport from Escherichia coli
RF|NP_418362 aquaglyceroporin from Escherichia coli K12
PFams: MIP
281 amino acids: PaperBLAST, CDD, Compare to cluster

AQP9_RAT / P56627 Aquaporin-9; AQP-9; Aquaglyceroporin-9 from Rattus norvegicus (Rat)
TC 1.A.8.9.2 / P56627 Aquaporin-9 (Aqp9) (permeable to glycerol, urea, polyols, carbamides, purines, pyrmidines, nucleosides, monocarboxylates, pentavalent methylated arsenicals and the arsenic chemotherapeutic drug, trisenox from Rattus norvegicus (Rat)
RF|NP_075249.1 aquaporin-9 from Rattus norvegicus
PFams: MIP
295 amino acids: PaperBLAST, CDD, Compare to cluster

TC 1.A.8.9.4 / Q6ZXT4 Aquaporin 1 (permeable to water, glycerol, dihydroxyacetone and urea) from Trypanosoma brucei brucei
GI|46518239 aquaglyceroporin 1 from Trypanosoma brucei brucei
PFams: MIP
321 amino acids: PaperBLAST, CDD, Compare to cluster

GLPF4_LACPL / F9UMX3 Glycerol uptake facilitator protein 4; D/L-lactic acid transporter; Lactic acid channel from Lactobacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)
PFams: MIP
238 amino acids: PaperBLAST, CDD, Compare to cluster

LARD_LACPL / F9UST3 D/L-lactic acid transporter; Lactate racemization operon protein LarD; Lactic acid channel from Lactobacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)
TC 1.A.8.2.4 / C6VJ63 GlpF1; transports water, dihydroxyacetone and glycerol as well as D,L-lactic acid from Lactobacillus plantarum (strain JDM1)
PFams: MIP
238 amino acids: PaperBLAST, CDD, Compare to cluster

GLPF2_LACPL / F9USY3 Glycerol uptake facilitator protein 2 from Lactobacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)
TC 1.A.8.2.5 / D7V7W8 GlpF2 from Lactobacillus plantarum subsp. plantarum ATCC 14917
PFams: MIP
235 amino acids: PaperBLAST, CDD, Compare to cluster

GLPF3_LACPL / F9UTW9 Glycerol uptake facilitator protein 3 from Lactobacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)
TC 1.A.8.2.6 / D7V8E7 GlpF3 from Lactobacillus plantarum subsp. plantarum ATCC 14917
PFams: MIP
240 amino acids: PaperBLAST, CDD, Compare to cluster

GLPF5_LACPL / F9UUB3 Glycerol uptake facilitator protein-like 5 from Lactobacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)
TC 1.A.8.2.7 / D7VEY8 GlpF4. Transports water, dihydroxyacetone and glycerol as well as D,L-lactic acid from Lactobacillus plantarum subsp. plantarum ATCC 14917
PFams: MIP
250 amino acids: PaperBLAST, CDD, Compare to cluster

AQP3_RAT / P47862 Aquaporin-3; AQP-3; 31.4 kDa water channel protein; Aquaglyceroporin-3 from Rattus norvegicus (Rat)
TC 1.A.8.9.1 / P47862 Aquaporin 3. 95% identical to the human orthologue. Poorly permeable to water, but more permeable to glycerol and arsenic trioxide from Rattus norvegicus (Rat)
PFams: MIP
292 amino acids: PaperBLAST, CDD, Compare to cluster

TC 1.A.8.9.9 / F6QEC2 Aquaporin/glycerol facilitator of 294 aas and 6 TMSs from Xenopus tropicalis
PFams: MIP
294 amino acids: PaperBLAST, CDD, Compare to cluster

TC 1.A.8.12.1 / P08995 Nodulin-26 aquaporin and glycerol facilitator, NIP (de Paula Santos Martins et al. 2015). Transports NH3 5-fold better than water in Hg2+-sensitive fashion from Glycine max (Soybean)
PFams: MIP
271 amino acids: PaperBLAST, CDD, Compare to cluster

TC 1.A.8.2.1 / P18156 Glycerol facilitator from Bacillus subtilis
PFams: MIP
274 amino acids: PaperBLAST, CDD, Compare to cluster

TC 1.A.8.2.3 / P52280 Probable glycerol uptake facilitator protein from Mycoplasma gallisepticum (strain R(low / passage 15 / clone 2))
PFams: MIP
243 amino acids: PaperBLAST, CDD, Compare to cluster

TC 1.A.8.9.3 / Q6Q1Q6 Major aquaglyceroporin, LmAQP1: transports water, glycerol, methylglyoxal, trivalent metalloids such as arsenite and antimonite, dihydroxyacetone and sugar alcohols. Also takes up the activated form or the drug, pentostam from Leishmania major
PFams: MIP
281 amino acids: PaperBLAST, CDD, Compare to cluster

TC 1.A.8.9.13 / Q8WPZ6 Aquaglycerolporin, Aqp (high permeability to ammonium, methylamine, glycerol and water) (Beitz et al., 2004) NH4+/NH3+CH3 transporter from Plasmodium falciparum
PFams: MIP
258 amino acids: PaperBLAST, CDD, Compare to cluster

TC 1.A.8.13.2 / Q9C4Z5 Hg2+-inhibitable aquaporin, AqpM (transports both water and glycerol as well as CO2) (Kozono et al., 2003; Araya-Secchi et al., 2011). Its 3-d structure has been determined to 1.7 Å. In AqpM, isoleucine replaces a key histidine residue found in the lumen of water channels, which becomes a glycine residue in aquaglyceroporins. As a result of this and other side-chain substituents in the walls of the channel, the channel is intermediate in size and exhibits differentially tuned electrostatics when compared with the other subfamilies from Methanobacterium thermoautotrophicum (strain Marburg / DSM 2133)
PFams: MIP
246 amino acids: PaperBLAST, CDD, Compare to cluster