Clusters of Characterized Proteins

Clustering the characterized proteins for hisE (phosphoribosyl-AMP cyclohydrolase) in L-histidine biosynthesis

Or see other characterized proteins similar to hisE

Or see all steps for L-histidine biosynthesis

Or cluster curated proteins matching a keyword

Definition of hisE

• Curated proteins or TIGRFams with EC 3.5.4.19
• HMM PF01502
• Ignore hits to CH_123581 when looking for 'other' hits (multifunctional enzyme that catalyzes three steps of histidine biosynthesis)
• Ignore hits to A1BPP9 when looking for 'other' hits (histidinol dehydrogenase (EC 1.1.1.23))
• Comment: A1BPP9 is annotated as hisD but is likely multifunctional, so similarity to it is ignored.

Fetched 8 sequences

Running BLASTp

Found similarities, at above 30% identity and 75% coverage, for 3 of these sequences

Found 1 clusters of similar sequences. Another 5 sequences are not clustered. Download as table or as draft rules or view by organism

Cluster 1 136-139 amino acids (not heteromeric)

HIS3_METVA / Q50837 Phosphoribosyl-AMP cyclohydrolase; PRA-CH; EC 3.5.4.19 from Methanococcus vannielii
Q50837 phosphoribosyl-AMP cyclohydrolase (EC 3.5.4.19) from Methanococcus vannielii
PFams: PRA-CH
136 amino acids: PaperBLAST, CDD, Compare to cluster

Q8YH95 phosphoribosyl-AMP cyclohydrolase (EC 3.5.4.19) from Brucella melitensis bv. 1
PFams: PRA-CH
139 amino acids: PaperBLAST, CDD, Compare to cluster

HIS3_METTH / O26347 Phosphoribosyl-AMP cyclohydrolase; PRA-CH; EC 3.5.4.19 from Methanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H) (Methanobacterium thermoautotrophicum)
PFams: PRA-CH
138 amino acids: PaperBLAST, CDD, Compare to cluster

Singletons (0/5 heteromeric)

HIS2_SCHPO / O59667 Histidine biosynthesis bifunctional protein his7; EC 3.5.4.19; EC 3.6.1.31 from Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
GI|3006138 phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphohydrolase His7; EC 3.5.4.19; EC 3.6.1.31 from Schizosaccharomyces pombe
PFams: PRA-CH, PRA-PH
417 amino acids: PaperBLAST, CDD

O82768 phosphoribosyl-AMP cyclohydrolase (EC 3.5.4.19; EC 3.6.1.31) from Arabidopsis thaliana
HIS2_ARATH / O82768 Histidine biosynthesis bifunctional protein hisIE, chloroplastic; Protein HISTIDINE BIOSYNTHESIS 2; EC 3.5.4.19; EC 3.6.1.31 from Arabidopsis thaliana (Mouse-ear cress)
PFams: PRA-CH, PRA-PH
281 amino acids: PaperBLAST, CDD

HIS2_YEAST / P00815 Histidine biosynthesis trifunctional protein; EC 3.5.4.19; EC 3.6.1.31; EC 1.1.1.23 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
PFams: PRA-CH, PRA-PH, Histidinol_dh
799 amino acids: PaperBLAST, CDD

P06989 putative bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase (EC 3.5.4.19; EC 3.6.1.31) from Escherichia coli (strain K12)
PFams: PRA-CH, PRA-PH
203 amino acids: PaperBLAST, CDD

HSERO_RS20310 phosphoribosyl-AMP cyclohydrolase (EC 3.5.4.19) from Herbaspirillum seropedicae SmR1
PFams: PRA-CH
166 amino acids: PaperBLAST, CDD