Clusters of Characterized Proteins

Clustering the characterized proteins for hisF (imidazole glycerol phosphate synthase, cyclase subunit) in L-histidine biosynthesis

Or see other characterized proteins similar to hisF

Or see all steps for L-histidine biosynthesis

Or cluster curated proteins matching a keyword

Definition of hisF

• Curated proteins matching hisF
• HMM TIGR00735
• Ignore hits to items matching imidazole glycerol phosphate synthase when looking for 'other' hits
• Curated sequence Q5NMD6: imidazole glycerol-phosphate synthase (subunit 2/2) (EC 4.3.2.10)
• Curated sequence Q8ZY16: imidazole glycerol-phosphate synthase (subunit 2/2) (EC 4.3.2.10)
• Curated sequence A4WHB6: imidazole glycerol-phosphate synthase (subunit 2/2) (EC 4.3.2.10)
• Curated sequence Q9SZ30: imidazole glycerol-phosphate synthase (EC 4.3.2.10). imidazole-glycerol-phosphate synthase (EC 4.3.2.10)
• Comment: Subunits are not always annotated consistently, so are added manually, and Q9SZ30 is a fusion protein of the two subunits

Fetched 7 sequences

Running BLASTp

Found similarities, at above 30% identity and 75% coverage, for 6 of these sequences

Found 1 clusters of similar sequences. Another 1 sequences are not clustered. Download as table or as draft rules or view by organism

Cluster 1 251-258 amino acids (heteromeric)

A4WHB6 imidazole glycerol-phosphate synthase (subunit 2/2) (EC 4.3.2.10) from Pyrobaculum arsenaticum
PFams: His_biosynth, Dus
Heteromeric, 251 amino acids: PaperBLAST, CDD, Compare to cluster

Q5NMD6 imidazole glycerol-phosphate synthase (subunit 2/2) (EC 4.3.2.10) from Zymomonas mobilis
PFams: His_biosynth
Heteromeric, 255 amino acids: PaperBLAST, CDD, Compare to cluster

Q8ZY16 imidazole glycerol-phosphate synthase (subunit 2/2) (EC 4.3.2.10) from Pyrobaculum aerophilum
PFams: His_biosynth, Dus
Heteromeric, 253 amino acids: PaperBLAST, CDD, Compare to cluster

Q9X0C6 imidazole-glycerol-phosphate synthase cycloligase subunit (EC 4.3.2.10) from Thermotoga maritima (strain ATCC 43589 / DSM 3109 / JCM 10099 / NBRC 100826 / MSB8)
HIS6_THEMA / Q9X0C6 Imidazole glycerol phosphate synthase subunit HisF; IGP synthase cyclase subunit; IGP synthase subunit HisF; ImGP synthase subunit HisF; IGPS subunit HisF; EC 4.3.2.10 from Thermotoga maritima (strain ATCC 43589 / DSM 3109 / JCM 10099 / NBRC 100826 / MSB8)
Q9X0C6 imidazole glycerol-phosphate synthase (subunit 2/2) (EC 4.3.2.10) from Thermotoga maritima
PFams: His_biosynth
Heteromeric, 253 amino acids: PaperBLAST, CDD, Compare to cluster

b2025 imidazole glycerol phosphate synthase subunit HisF (EC 4.3.2.10) from Escherichia coli K-12 substr. MG1655
P60664 imidazole glycerol phosphate synthase subunit HisF (EC 4.3.2.10) from Escherichia coli (strain K12)
HIS6_ECOLI / P60664 Imidazole glycerol phosphate synthase subunit HisF; IGP synthase cyclase subunit; IGP synthase subunit HisF; ImGP synthase subunit HisF; IGPS subunit HisF; EC 4.3.2.10 from Escherichia coli (strain K12)
RF|NP_416529 IGP synthase cyclase subunit; EC 4.1.3.- from Escherichia coli K12
PFams: His_biosynth
Heteromeric, 258 amino acids: PaperBLAST, CDD, Compare to cluster

HIS6_THET8 / Q7SIB9 Imidazole glycerol phosphate synthase subunit HisF; IGP synthase cyclase subunit; IGP synthase subunit HisF; ImGP synthase subunit HisF; IGPS subunit HisF; EC 4.3.2.10 from Thermus thermophilus (strain ATCC 27634 / DSM 579 / HB8)
Q7SIB9 imidazole glycerol-phosphate synthase (subunit 1/2) (EC 4.3.2.10) from Thermus thermophilus
PFams: His_biosynth
Heteromeric, 252 amino acids: PaperBLAST, CDD, Compare to cluster

Singletons (0/1 heteromeric)

Q9SZ30 imidazole-glycerol-phosphate synthase (EC 4.3.2.10) from Arabidopsis thaliana
Q9SZ30 imidazole glycerol-phosphate synthase (EC 4.3.2.10) from Arabidopsis thaliana
PFams: GATase, GATase_3, His_biosynth
592 amino acids: PaperBLAST, CDD