Clusters of Characterized Proteins

Clustering the characterized proteins for hisJ (L-histidine ABC transporter, substrate-binding component HisJ) in L-histidine catabolism

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Definition of hisJ

• Curated sequence CH_014295: histidine ABC transporter, periplasmic histidine-binding protein HisJ. Histidine-binding periplasmic protein, component of Histidine/Arginine/Lysine (basic amino acid) uptake porter, HisJ/ArgT/HisP/HisM/HisQ [R, R, C, M, M, respectively] (Gilson et al. 1982). HisJ binds L-His (preferred), but 1-methyl-L-His and 3-methyl-L-His also bind, while the dipeptide carnosine binds weakly; D-histidine and the histidine degradation products, histamine, urocanic acid and imidazole do not bind. L-Arg, homo-L-Arg, and post-translationally modified methylated Arg-analogs also bind with the exception of symmetric dimethylated-L-Arg. L-Lys and L-Orn show weaker interactions with HisJ and methylated and acetylated Lys variants show poor binding.The carboxylate groups of these amino acids and their variants are essential. histidine ABC transporter periplasmic binding protein (EC 7.4.2.1)
• Curated sequence CH_018185: histidine ABC transporter, periplasmic histidine-binding protein HisJ. Histidine-binding periplasmic protein; HBP
• Curated sequence Q9HU31: Amino acid (Lysine/arginine/ornithine/histidine/octopine) ABC transporter periplasmic binding protein, component of Amino acid transporter, PA5152-PA5155. Probably transports numerous amino acids including lysine, arginine, histidine, D-alanine and D-valine (Johnson et al. 2008). Regulated by ArgR
• Ignore hits to AO356_09900 when looking for 'other' hits (ABC transporter for L-Lysine, periplasmic substrate-binding component)

Fetched 3 sequences

Running BLASTp

Found similarities, at above 30% identity and 75% coverage, for 3 of these sequences

Found 1 clusters of similar sequences. Download as table or as draft rules or view by organism

Cluster 1 250-260 amino acids (2/3 heteromeric)

b2309 histidine ABC transporter periplasmic binding protein (EC 7.4.2.1) from Escherichia coli K-12 substr. MG1655
TC 3.A.1.3.29 / P0AEU0 Histidine-binding periplasmic protein, component of Histidine/Arginine/Lysine (basic amino acid) uptake porter, HisJ/ArgT/HisP/HisM/HisQ [R, R, C, M, M, respectively] (Gilson et al. 1982). HisJ binds L-His (preferred), but 1-methyl-L-His and 3-methyl-L-His also bind, while the dipeptide carnosine binds weakly; D-histidine and the histidine degradation products, histamine, urocanic acid and imidazole do not bind. L-Arg, homo-L-Arg, and post-translationally modified methylated Arg-analogs also bind with the exception of symmetric dimethylated-L-Arg. L-Lys and L-Orn show weaker interactions with HisJ and methylated and acetylated Lys variants show poor binding.The carboxylate groups of these amino acids and their variants are essential from Escherichia coli (strain K12)
GB|AAC75369.1 histidine ABC transporter, periplasmic histidine-binding protein HisJ from Escherichia coli
PFams: SBP_bac_3
Heteromeric, 260 amino acids: PaperBLAST, CDD, Compare to cluster

HISJ_SALTY / P02910 Histidine-binding periplasmic protein; HBP from Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
GB|AAV76512.1 histidine ABC transporter, periplasmic histidine-binding protein HisJ from Salmonella enterica subsp. enterica serovar Typhimurium
PFams: SBP_bac_3
260 amino acids: PaperBLAST, CDD, Compare to cluster

TC 3.A.1.3.23 / Q9HU31 Amino acid (Lysine/arginine/ornithine/histidine/octopine) ABC transporter periplasmic binding protein, component of Amino acid transporter, PA5152-PA5155. Probably transports numerous amino acids including lysine, arginine, histidine, D-alanine and D-valine (Johnson et al. 2008). Regulated by ArgR from Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228)
PFams: SBP_bac_3, Lig_chan-Glu_bd
Heteromeric, 250 amino acids: PaperBLAST, CDD, Compare to cluster